CN105641349A - Traditional Chinese medicine composition with efficacy of inhibiting generation of lactic acid and preparation method of traditional Chinese medicine composition - Google Patents

Abstract

The invention discloses traditional Chinese medicine composition with efficacy of inhibiting generation of lactic acid and a preparation method of the traditional Chinese medicine composition. The composition is prepared from raw materials including hedyotis hedyotidea, sarmentose pepper herbs, smilax riparia, twotooth achyranthes roots, Parabarium chunianum, leaves and twigs of Fruticose Breynia, leaves of Chinese desmos, herba of Inula cappa DC., diverse wormwood herbs, Entada phaseoloides stems, Hyptis suaveolens, radix cudraniae, zanthoxylum nitidum var. tomentosum, suberect spatholobus stems, twigs and leaves of common claoxylon, roots of solanum surattense Burm. f., pubescent angelica roots, semen impatientis, fruits of largeflower gardenia, cloves, nutgrass galingale rhizomes, roots of Kadsura coccinea, herba centipedae, lindera aggregate, Lobelia dauidii Franch., prepared kusnezoff monkshood roots, camphor, herba hyperici japonici, roughhaired holly roots, cochinchina momordica seeds, rhizoma atractylodis and cassia twigs. The invention further provides a preparation method of the traditional Chinese medicine composition with the efficacy of inhibiting generation of lactic acid.

Description

A kind of have the Chinese medicine composition and its preparation method that suppress lactic acid to produce effect

Technical field

The present invention relates to pharmaceutical sanitary field, be specifically related to a kind of have suppress lactic acid to produce Chinese medicine composition and its preparation method of effect.

Background technology

Lactic acid is due in moving process, the intermediate product produced in the metabolic process of glucose in body. Due to motion relative excess, exceed the intensity of anaerobic exercise, and causing the lactic acid produced in body can not be decomposed into water and carbonic acid gas within the short period of time further, oxygen supply is not enough and forms anaerobic metabolism, thus causes a large amount of excessive product lactic acid to form accumulation in body. Lactic acid accumulation can cause aching of local muscle.

Lactic acid in the accumulation of muscle, can form the decline of muscle pH value in vigorous exercise process, causes the reduction of muscle enzymic activity, and then forms the fatigue phenomenon (acute sore muscle) of muscle activity. Therefore after accelerating motion, the removing of lactic acid is just helpful for improving agonistic sports ability, and lactic acid has three outlets, and one is enter plastosome equally to carry out aerobic metabolism; Two is generate glucose by glyconeogenesis approach, all right glycogen biosynthesis of glucose; Three is enter blood to transport to liver cell metabolism; Finally, minute quantity lactic acid is also had directly can to drain away with sweat and urine.

Usually accelerating the way that lactic acid removes after motion is to jog or other mode of motion (intensity is about the 35% to 65% of maximal oxygen oxygen amount) easily, carry out arranging motion, not only can accelerate the reaction that blood lactase acid is delivered to liver and stored and be oxidized, but also heart can be increased and utilize lactic acid as the amount of fuel with work flesh, really promote the eliminating efficiency of blood lactase acid after moving. In addition, carry out after motion massaging or stretching also contributes to promoting the conversion of lactic acid, but research recently is not propped up and taken that view. In practice, somebody finds, the high oxygen concentration sucking about 20 minutes after motion also can allow human body remove some metabolism accumulation product quickly.

In sports medical science circle, how to solve lactic acid and pile up the problem brought. Allow health recover rapidly function, also become the focus of concern. From current result of study, mainly contain two kinds of thinkings: one is the ability by increasing aerobic metabolism, directly reduces the generation of lactic acid; Two is the function promoting glycolysis-system, allows health more tolerate the lactic acid generated already, and accelerates transhipment and the metabolism of lactic acid.

At present relevant Chinese medicine composition for suppressing lactic acid to produce, accelerate lactic acid metabolism, to alleviate motion and ache the report felt less, for this situation, contriver, through a large amount of tests, finally determines and proposes the present invention.

Summary of the invention

It is an object of the invention to provide a kind of have suppress lactic acid to produce the Chinese medicine composition of effect;

It is a further object of the present invention to provide a kind of preparation method with the Chinese medicine composition suppressing lactic acid to produce effect.

It is an object of the invention to by following technical scheme realize:

Of the present invention a kind of have suppress lactic acid to produce the Chinese medicine composition of effect, it it is be prepared from by the raw material of following weight part: Stem and leaf of Hedyotidous hedyotis 70-82 part, false 70-82 part, riparian greenbrier root and rhizome 70-82 part, root of bidentate achyranthes 70-82 part, Radix seu Caulis Parabarii 70-82 part, GUIHUAFU 70-82 part, leaf of Radix Glycosmidis Citrifoliae 70-82 part, Sheepear Inula Herb 70-82 part, Herba Artemisiae Anomalae 70-82 part, Caulis Bauhihiae Championii 70-82 part, bee saage 70-82 part, Root of Tricuspid Cudrania 70-82 part, Radix Zanthoxyli 70-82 part, Yunnan Caulis Spatholobi 70-82 part, Twig and leaf of Common Claoxylon 70-82 part, Radix Solani indici 70-82 part, levisticum 70-82 part, impetuous 70-82 part, build Cape jasmine 70-82 part, cloves 35-42 part, rhizoma cyperi 135-170 part, Scarlet Kadsura Root 135-170 part, Small Centipeda Herb 70-82 part, root of three-nerved spicebush 70-82 part, big Herba Lobeliae Chinensis 70-82 part, Radix Aconiti Preparata 35-42 part, camphor 2-5 part, Herba Hyperici Japonici 70-82 part, Flos Ilicis Asprellae 70-82 part, Semen Momordicae 70-82 part, rhizoma atractylodis 70-82 part, cassia twig 13-18 part.

Preferably, it it is be prepared from by the raw material of following weight part: Stem and leaf of Hedyotidous hedyotis 76 parts, false 76 parts, riparian greenbrier root and rhizome 76 parts, the root of bidentate achyranthes 76 parts, Radix seu Caulis Parabarii 76 parts, GUIHUAFU 76 parts, leaf of Radix Glycosmidis Citrifoliae 76 parts, Sheepear Inula Herb 76 parts, Herba Artemisiae Anomalae 76 parts, Caulis Bauhihiae Championii 76 parts, bee saage 76 parts, Root of Tricuspid Cudrania 76 parts, Radix Zanthoxyli 76 parts, Yunnan Caulis Spatholobi 76 parts, Twig and leaf of Common Claoxylon 76 parts, Radix Solani indici 76 parts, levisticum 76 parts, impetuous 76 parts, build Cape jasmine 76 parts, cloves 38 parts, rhizoma cyperi 153 parts, Scarlet Kadsura Root 153 parts, Small Centipeda Herb 76 parts, the root of three-nerved spicebush 76 parts, big Herba Lobeliae Chinensis 76 parts, Radix Aconiti Preparata 38 parts, camphor 3 parts, Herba Hyperici Japonici 76 parts, Flos Ilicis Asprellae 76 parts, Semen Momordicae 76 parts, rhizoma atractylodis 76 parts, cassia twig 15 parts.

The following is the crude drug source of the present invention:

Stem and leaf of Hedyotidous hedyotis: this product is the dry rattan stem of madder wort Stem and leaf of Hedyotidous hedyotis Hedyotishedyotidea (DC.) Merr.. The whole year can adopt, and cleans, and section or section, dry. [nature and flavor with return through] are micro-sweet, cool. Return spleen, Liver Channel. [function with cure mainly] relieving superficies by cooling, dispelling, collateral-activating, swelling and pain relieving. For cold, fever, limbs muscles and bones is ached, rheumatic arthralgia, wound.

False: this product is the dry aerial parts of the false PipersarmentosumRoxb. of piperaceae plant. Summer, autumn tap when plant strain growth is luxuriant, are bundled into little handle, dry. [nature and flavor] are pungent, temperature. [function with cure mainly] expelling wind and removing dampness, promoting flow of QI and blood, swelling and pain relieving, resolving phlegm and removing blood stasis. For wound, treating rheumatic ostealgia, the cold pain of stomach abdomen, eats stagnant abdominal distension, cough due to wind and cold.

Riparian greenbrier root and rhizome: this product is the dry root machine rhizome of chinaroot greenbrier section plant riparian greenbrier root and rhizome SmilaxripariaA.DC.. Summer, autumn excavate, and remove rattan stem and silt, dry. [nature and flavor] are sweet, bitter, flat. [function with cure mainly] channels sootheing and network vessel quickening, inrigorating qi and promoting blood circulation, expelling phlegm for arresting cough. For arthralgia and myalgia, deficiency of vital energy edema, wound, cough is spitted blood.

The root of bidentate achyranthes: this product is the dry root of amaranthaceous plant root of bidentate achyranthes AchyranthesbidentataBl.. Winter excavates when stem leaf is withered, removes fibrous root and silt, is bundled into little handle, shines as after wrinkle, is cut together on top, dry. [nature and flavor with return through] are bitter, sweet, sour, flat. Return liver, kidney channel. [function is with curing mainly] stimulates the menstrual flow by the stasis of blood, invigorating the liver and kidney, strengthening the bones and muscles, and inducing diuresis for treating stranguria syndrome is ensuringd proper downward flow of the blood. For through closing, dysmenorrhoea, soreness of waist and knee joint, muscles and bones is unable, drenches card, oedema, and headache is dizzy, toothache, day sore, spit blood, bleeding from five sense organs or subcutaneous tissue.

Radix seu Caulis Parabarii: this product is the dry bark of apocynaceae plant Radix seu Caulis Parabarii rattan ParabariumchunianumTsiang, hair eucommia vine ParabariumhuaitingiiChunetTsiang, eucommia vine Parabariummicranthun (A.DC.) Pierre or flower hide glue rattan EcdysantherautilisHay.etKaw.. The whole year can adopt, and strips bark, drying. [nature and flavor with return through] are bitter, puckery, micro-pungent, flat. [function with cure mainly] dispelling, collateral-activating, strong waist knee, strengthening the bones and muscles, detumescence. For poliomyelitis, treating rheumatic ostealgia, wound.

GUIHUAFU: this product is the dry complete stool of euphorbia plant Fruticose Breyniae Leaf and Twig Breyniafruticosa (L.) Hook.f.. The whole year all can excavate, and removes silt, dries. [nature and flavor] micro-bitterness, cool; Slightly poisonous. [function with cure mainly] is clearing heat and detoxicating, and blood stasis removing analgesic, restrains antipruritic. For the heating of abnormal pigmentary deposit on the skin acute diseases such as cholera and sunstroke, headache, acute gastroenteritis, tonsillitis, puerperal uterine contraction pain, dysfunctional uterine hemorrhage, poison sore carbuncle swells, paint poison, skin eczema, allergic dermatitis, snakebite.

Leaf of Radix Glycosmidis Citrifoliae: this product is the dry leave of rutaceae little Hua Root of Citrusleaf Glycosmis Glycosmisparviflora (Sims) Kurz. [nature and flavor] are bitter, micro-pungent, flat. [function with cure mainly] dissipating blood stasis for subsidence of swelling, reduces phlegm, disappears long-pending. For wound, cold cough, pain that dyspepsia is swollen.

Sheepear Inula Herb: this product is the dry aerial parts of feverfew Sheepear Inula Herb Inulacappa (Buch. Ham.) DC.. Summer, autumn tap, and remove impurity, dry. [nature and flavor] hardship pungent, micro-, temperature. Return lung, liver, stomach warp. [function is with curing mainly] dispels the wind, and profit is wet, promoting qi circulation, resolving food retention. For rheumatic arthritis, chest diaphragm ruffian is vexed, malaria, and dysentery is had loose bowels, and postpartum catches a cold, hepatitis, hemorrhoid, scabies.

Herba Artemisiae Anomalae: this product is feverfew artemisia anomalas ArtemisiaanomalaS.Moore or the dry aerial parts of white bud wormwood artemisia ArtemisiaactifloraWall.ex.DC.. Tap when summer, fall flowering, remove impurity, dry. [nature and flavor] micro-hardship, pungent, temperature. [function with cure mainly] promoting blood circulation to remove blood stasis, inducing meastruation to relieve menalgia, inducing diuresis and reducing edema, removing food retention and flatulence. For extravasated blood stomachache in postpartum, menoxenia, amenorrhoea, dyspepsia abdominal distension, wound.

Caulis Bauhihiae Championii: this product is the dry rattan stem of leguminous plants rattan Entadaphaseoloides (Linnaeus) Merrill. The whole year all can receive, and cleans, cuts sheet, dry. [nature and flavor with return through] hardship puckery, micro-, cool. Slightly poisonous. Return liver, the spleen channel. [function is with curing mainly] dispels rheumatism, blood circulation promoting competent silt. For rheumatic arthralgia, lumbago and skelalgia, treating swelling and pain by traumatic injury.

Bee saage: this product is the dry full grass of labiate bee saage Hyptissuaveolens (L.) Poit.. Summer and autumn gathers, and removes impurity, dries in the shade. [nature and flavor] are pungent, bitter, flat. The loose stasis of blood of [function with cure mainly] dispelling wind, promoting the circulation of qi profit is wet, removing toxic substances, pain relieving. For cold headache, flatulence, treating rheumatic ostealgia, treating swelling and pain by traumatic injury, wound hemorrhage, carbuncle sore tumefacting virus, worm snakebite, eczema, dermatitis.

Root of Tricuspid Cudrania: this product is the dry root of moraceae plants cudrania cochinchinensis Cudraniacochinchinensis (Lour.) KudoetMasam.. The whole year all can excavate, and removes fibrous root, cleans, section or section, dry. [nature and flavor] micro-hardship, cool. [function with cure mainly] cough-relieving, removing jaundice, invigorates blood circulation, logical network. For pulmonary tuberculosis, jaundice due to damp-heat, pain over the hypochondriac region, fall and flutter stasis of blood pain, rheumatic arthralgia.

Radix Zanthoxyli: this product is the dry complete stool of rutaceae Radix Zanthoxyli Zanthoxylumnitidum (Roxh.) DC.var.tomentosumHuang. The whole year all can gather, and removes impurity, and section is dry. [nature and flavor] are pungent, bitter, temperature; Slightly poisonous. [function cures mainly] dispelling wind and removing obstruction in the collateral, swelling and pain relieving. For treating rheumatic ostealgia, larynx numbness, scrofula, stomachache, toothache, acute diseases such as cholera and sunstroke is sick, wound, burn and scald, venomous snake bite.

Yunnan Caulis Spatholobi: this product is the dry rattan stem of leguminous plants spatholobus suberectus SpatholobussuberectusDunn. Autumn, season in winter two gather, and remove branches and leaves, and section, dries. [nature and flavor with return through] are bitter, sweet, temperature. Return liver, kidney channel. [function with cure mainly] blood circulation promoting and enriching, menstruction regulating and pain relieving, stimulates the circulation of the blood and cause the muscles and joints to relax. For menoxenia, dysmenorrhoea, through closing, rheumatic arthralgia, paralysis and numbness, the deficiency of blood is sallow.

Twig and leaf of Common Claoxylon: this product is the arid zones leaf spray of euphorbia plant princess tree tree Claoxylonpulot (Burm.) Merr.. The whole year all can gather, and dries. [nature and flavor] are light, flat; Slightly poisonous. [function is with curing mainly] dispels rheumatism, blood stasis removing analgesic. For rheumatic arthralgia, wound stasis of blood pain.

Radix Solani indici: this product is the dry root of plant of Solanaceae Fruit of Khasi Nightshade SolanumindicumL. ox eggplant SolanumsurattenseBurm.f. water eggplant SolanumtorvumSwartz. or Fruit of yellowfruit nightshade SolanumxanthocarpumSchrad.et.Wendl. and old stem. The whole year can adopt, and removes fibrous root, cleans, dries. [nature and flavor] hardship pungent, micro-, tepor. Slightly poisonous. [function with cure mainly] promoting blood circulation to remove blood stasis, swelling and pain relieving. For wound, lumbar muscle strain, stomachache, toothache, rheumatalgia, sore poison.

Levisticum: this product is the dry root of samphire Angelica pubescens AngelicapubescensMaxim.f.biserrataShanetYuan. Seedling at the beginning of spring just germinateed or autumn Mo stem leaf withered time excavate, remove fibrous root and silt, be dried to half-dried, bank up 2��3 days, be dried to absolutely dry after feeling like jelly again. [nature and flavor with return through] are pungent, bitter, tepor. Return kidney, bladder warp. [function is with curing mainly] dispels rheumatism, numbness relieving and pain relieving. For arthralgia due to wind-cold-dampness pathogen BI syndrome, waist knee pain, few cloudy volt public attention gout is cold holds wet headache under the arm.

Impetuous: this product is the dry mature seed of Balsaminaceae plant Flower of Garden Balsam ImpatiensbalsaminaL.. Summer, autumn gather when fruit is about to ripe, dry, and remove pericarp and impurity. [nature and flavor with return through] micro-hardship, pungent, temperature; Slightly poisonous. Return lung, Liver Channel. [function is with curing mainly] breaks the soft heavily fortified point of blood, disappears long-pending. For note of the ancient Chinese lump in the abdomen lump in the abdomen, through closing, dysphagic.

Build Cape jasmine: this product is the dry mature fruit of madder wort great Hua mast GardeniajasminoidesEllisvar.grandillora (Lour.) Nakai. Collecting fruit about October, cuts the calyx head deposited place, dries or dry after drying or boiling. [nature and flavor] are bitter, cold. [function with cure mainly] subsides a swelling active. For controlling injury from falling down sprain and contusion, the swollen pain of skin green grass or young crops.

Cloves: this product is the dry flower of plant clove of myrtaceae EugeniacaryophyllataThunb.. Pluck when bud turns red by green, dry. [nature and flavor with return through] are pungent, temperature. Return spleen, stomach, lung, kidney channel. [function with cure mainly] warming middle-JIAO to send down the adverse QI, kidney tonifying is supporing yang. For insufficiency of spleen-YANG, hiccup is vomitted, and food is few vomits and diarrhoea, trusted subordinate's crymodynia, impotence of suffering from a deficiency of the kidney.

Rhizoma cyperi: this product is the dry rhizome of sedge nutgrass flatsedge CyperusrotundusL.. Autumn excavates, and burns feeler, puts and dries after slightly boiling in boiling water or steaming, or directly dries after burning. [nature and flavor with return through] hardship pungent, micro-, micro-sweet, flat. Return liver, spleen, three burnt warps. [function with cure mainly] dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving. For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, the taste stagnation of the circulation of vital energy, gastral cavity abdomen ruffian is vexed, and swollen full pain, menoxenia, through closing dysmenorrhoea.

Scarlet Kadsura Root: this product is the dry root of Magnoliacea plant thick leaf shizandra berry Kadsuracoccinea (Lem.) A.C.Smith. Record in " Chinese Pharmacopoeia " version in 1977. Or Kadsura Pepper Stem, i.e. the dry rattan stem of Kadsura heteroclita Kadsuraheteroclita (Roxb.) Craib, records in " Guangxi Chinese medicinal materials standard ". [nature and flavor] are sweet, micro-pungent, temperature. [function with cure mainly] expelling wind and cold, promoting the circulation of QI to relieve pain, stimulate the circulation of the blood and cause the muscles and joints to relax. For rheumatic arthritis, lumbar muscle strain, flu, postpartum paralysis.

Small Centipeda Herb: this product is the dry full grass of feverfew Small Centipeda Herb Centipedaminima (L.) A.Br.etAschers.. Summer, season in autumn two gather when the flowers are in blossom, wash silt, dry. [nature and flavor with return through] are pungent, temperature. Return lung channel. [function with cure mainly] expelling cold, eliminating, relieving stuffy nose, cough-relieving. For headche due to wind-cold, coughing with a lot of sputum, have a stuffy nose obstructed, nasosinusitis runny nose.

The root of three-nerved spicebush: this product is the dried root of canella root of three-nerved spicebush Linderaaggregata (Sims) Kosterm.. The whole year all can excavate, and removes thin root, cleans, takes advantage of fresh slices, dry, or directly dry. [nature and flavor with return through] are pungent, temperature. Return lung, spleen, kidney, bladder warp. [function with cure mainly] promoting the circulation of QI to relieve pain, temperature kidney is loose cold. For QI stagnated by cold, chest abdominal distention and pain, the circulation of vital energy in the wrong direction breathes heavily urgency, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia pain, through cold stomachache.

Big Herba Lobeliae Chinensis: this product is Begoniaceae plant thick beak Flower of Evans Begonia BegoniacrassirostrisIrmsch., splits the dry root stock of leaf Flower of Evans Begonia BegoniapalmataD.Don or Pharmacognostical Study BegoniapedatifidaLevl.. The whole year can adopt, and digs and gets root stock, removes fibrous root, cleans, dry. [nature and flavor] are sour, puckery, cool. [function with cure mainly] is clearing heat and detoxicating, swelling and pain relieving. For swelling and pain in the throat, treating rheumatic ostealgia, treating swelling and pain by traumatic injury, toothache, venomous snake bite, scalds burn.

Radix Aconiti Preparata: this product is this product is sheet that is irregular or Yangtze River Delta shape. Surface chocolate or tawny, have taupe brown form layers ring grain. Body is light, and matter is crisp, and section is glossy. Gas is micro-, and micro-have numb feeling in the tongue. [nature and flavor with return through] are pungent, bitter, heat; Poisonous. The thoughts of returning home, liver, kidney, the spleen channel. [function is with curing mainly] dispels rheumatism, antalgic. For arthralgia due to wind-cold-dampness pathogen BI syndrome, arthralgia, trusted subordinate's crymodynia, cold hernia is had a pain and is anaesthetized pain relieving.

Camphor: this product is 1,7,7 trimethylammonium two ring [2.2.1] heptane 2 ketone is extract (natural camphor) in canella or obtain (artificial camphor) by chemical synthesis. [function with cure mainly] orifice opening; Qi stagnation removing; Ward off foul; Killing parasites to relieve itching; Swelling and pain relieving. Main pyreticosis coma; Middle evil is dampinged off, and acute filthy disease is vomited and diarrhoea and suffered from abdominal pain; Cold-dampness beriberi; Scabies stubborn dermatitis; The favus of the scalp; Pernio; Ulcer on the shank; Burn due to hot liquid or fire; Traumatic pain; Toothache; Wind fire cute conjunctivitis.

Herba Hyperici Japonici: this product is the dry full grass of Garcinia maingayii Herba Hyperici Japonici HypericumjaponicumThunb.. Spring, season in summer two excavate when the flowers are in blossom, remove impurity, dry. [nature and flavor with return through] are bitter, pungent, flat. Return liver, the spleen channel. [function with cure mainly] eliminating damp-heat, dissipating blood stasis for subsidence of swelling. For acute and chronic hepatitis, sore furuncle carbuncle swells.

Flos Ilicis Asprellae: this product is dry root and the stem of holly plant gradations marked on the beam of steelyard tree Ilexasprella (HookeretAmott) ChampionexBentham. The whole year all can gather, and removes spray and leaf, cleans, cuts or be split into sheet, block or section, dry when taking advantage of fresh. [nature and flavor with return through] are bitter, micro-sweet, cool. Return lung, spleen, stomach warp. [function with cure mainly] is clearing heat and detoxicating, promotes the production of body fluid to quench thirst, relieving sore throat and diminishing swelling, blood stasis removing analgesic. For cold, fever, cough due to lung-heat, Tianjin wound is thirsty, swelling and pain in the throat, falls and beats stasis of blood pain.

Semen Momordicae: this product is the dry mature seed of cucurbitaceous plant Momordica cochinchiensis Momordicacochinchinensis (Lour.) Spreng.. Gather winter mature fruit, cut open, shine to half-dried, remove pulp, take out seed, dry. [nature and flavor with return through] are bitter, micro-sweet, cool; Poisonous. Return liver, spleen, stomach warp. [function with cure mainly] mass dissipating and swelling eliminating, attacks poison and treats sore. For sore swollen toxin, acute mastitis, scrofula pestilence, anal fistula, chronic eczema, the favus of the scalp.

Rhizoma atractylodis: this product is the dry rhizome of feverfew thatch rhizoma atractylodis Atractylodeslancea (Thunb.) DC. or Atractylis chinensis Atractylodeschinensis (DC.) Koidz.. Spring, Qiu Erji excavate, and remove silt, dry, hit fibrous root. [nature and flavor with return through] are pungent, bitter, temperature. Return spleen, stomach, Liver Channel. [function with cure mainly] is drying damp and strengthening spleen, and dispel the wind Ao Han, bright order. For retention of dampness in middle-JIAO, distension and fullness in the abdomen, having loose bowels, oedema, beriberi impotence is knitted, and rheumatic arthralgia, common cold caused by wind-cold, yctalopia, eyes dusk is puckery.

Cassia twig: this product is the dry spray of canella Chinese cassia tree CinnamomumcassiaPresl. Spring, Xia Erji gather, and except defoliation, dry, or section is dried. [nature and flavor] are pungent, sweet, temperature. The thoughts of returning home, lung, bladder warp. [function with cure mainly] sweating solution flesh, promoting the flow of QI-blood by warming the meridian, supporing yangization gas, the flat gas that spins. For common cold caused by wind-cold, coldness and pain in the epigastrium, blood is cold through closing, and arthralgia, phlegm and retained fluid, oedema, palpitaition, to globefish.

The another aspect of the present invention there is provided the preparation method of the activeconstituents of Chinese medicine composition of the present invention, and the method adopts water extraction. Concrete preparation method is as follows:

Take Stem and leaf of Hedyotidous hedyotis, false, riparian greenbrier root and rhizome, the root of bidentate achyranthes, Radix seu Caulis Parabarii, GUIHUAFU, leaf of Radix Glycosmidis Citrifoliae, Sheepear Inula Herb, Herba Artemisiae Anomalae, Caulis Bauhihiae Championii, Root of Tricuspid Cudrania, Radix Zanthoxyli, Yunnan Caulis Spatholobi, Twig and leaf of Common Claoxylon, Radix Solani indici, levisticum, impetuous, build Cape jasmine, cloves, rhizoma cyperi, Scarlet Kadsura Root, Small Centipeda Herb, big Herba Lobeliae Chinensis, Radix Aconiti Preparata, Herba Hyperici Japonici, Semen Momordicae, the supersound extraction that adds water 2-3 time, each amount of water is equivalent to 6-12 times of medicinal material gross weight, each extraction time is 1-3 hour, united extraction liquid, filter, filtrate concentrate to relative density when 60-80 DEG C be the clear cream of 1.05-1.20, take camphor, rhizoma atractylodis, cassia twig, Flos Ilicis Asprellae, bee saage, the root of three-nerved spicebush is placed in micro-powder pulverizer, it is crushed into ultrafine powder, ultrafine powder is mixed with clear cream, obtain.

The Chinese medicine composition ached feel for the preparation of suppression lactic acid generation, quickening lactic acid metabolism, alleviation motion of the present invention, can with pharmaceutically acceptable carrier combination, make various common dosage forms, such as tablet, granule, capsule, chewable tablet, pill etc.

The pharmaceutically acceptable carrier of the present invention includes but not limited to following:

Thinner: starch, Icing Sugar, lactose, dextrin, Microcrystalline Cellulose, inorganic salt, glycitols etc.

Wetting agent and tackiness agent: purified water, ethanol, gelatin, polyoxyethylene glycol, derivatived cellulose etc.

Disintegrating agent: starch, sodium starch glycolate, derivatived cellulose, polyvinylpolypyrrolidone etc.

Lubricant: Magnesium Stearate, micropowder silica gel, talcum powder, polyoxyethylene glycol etc.

Solubility promoter: water, ethanol, glycerine, propylene glycol, Liquid Paraffin, vegetables oil etc.

Correctives: sucrose, monose, perfume compound etc.

Sanitas: phenylformic acid, Sorbic Acid, methyl esters, second ester, propyl ester etc.

Fang Xie: we's card is impaired by the excessive vigour of forced labour, gas is hindered and hematogenous blockage, and disease sees stiffness of the muscle and joint, and four limbs are heavy, spiritlessness and weakness, stringy and hesitant pulse etc. This disease is theory of traditional Chinese medical science to the disease of the body fatigue of tired somatotype, controls and should relax the muscles and stimulate the blood circulation, promoting the circulation of QI to relieve pain, warming channel to dredge meridian. Reusing Scarlet Kadsura Root and the root of bidentate achyranthes in side for monarch, Scarlet Kadsura Root taste is pungent, warm in nature, and benefaction meridian qi and blood and temperature support passages through which vital energy circulates, the merit of pain relieving of holding concurrently again; The root of bidentate achyranthes has and stimulates the menstrual flow by the stasis of blood, easing joint movement effect, share with Scarlet Kadsura Root and relaxes through invigorating blood circulation for monarch plays altogether, the merit of promoting the circulation of QI to relieve pain, particularly suitable in this card. Cassia twig merit is apt to promoting the flow of QI-blood by warming the meridian, can the vigorous passages through which vital energy circulates gas blood of principal drug assistance; Levisticum is apt to numbness relieving and pain relieving, with the disease controlling the tired waist knee pain of labor; The card that all labor is tired, must impairment of QI-blood, Fang Zhongchen with Yunnan Caulis Spatholobi blood circulation promoting and enriching, again can principal drug assistance menstruction regulating and pain relieving, the merit stimulated the circulation of the blood and cause the muscles and joints to relax. Above three medicines are ministerial drug altogether. We's assistant is to build Cape jasmine, riparian greenbrier root and rhizome and Radix seu Caulis Parabarii, and building Cape jasmine has the active merit of detumescence, again because of its bitter cold nature and flavor, can in anti-side all flavour of a drug pungent loose too; Riparian greenbrier root and rhizome function is invigorated blood circulation, and regulates channels and activates collateral, and is apt to control internal lesion caused by overexertion pain in the back; Radix seu Caulis Parabarii strengthens psoas, and the effect of strengthening the bones and muscles is good, is strong body basis; Work sweating, the heresy easily having a cold when wind, Fang Zhongzuo, with Small Centipeda Herb expelling cold, eliminating, helps cassia twig to arrogate to oneself the merit induced sweat. Camphor makes medicine for we, has the effect of warming and odynolysis, again can all medicine medicine gesture of walk help. In side, all medicines, share and play promoting blood circulation and removing blood stasis altogether, promoting the circulation of QI to relieve pain, the merit stimulated the circulation of the blood and cause the muscles and joints to relax.

Provided by the invention a kind of have the Chinese medicine composition suppressing lactic acid to produce effect and have the following advantages:

1, in prescription of the present invention, each medicine share, and jointly plays promoting blood circulation and removing blood stasis, promoting the circulation of QI to relieve pain, the effect of the merit stimulated the circulation of the blood and cause the muscles and joints to relax, it is possible to play the effect alleviated preferably and move and ache. Give the mouse of the present invention, there is significant difference compared with comparative example group. Test-results points out the present invention mouse to have suppression lactic acid produce, accelerate lactic acid metabolism, alleviate the effect moved and ache and feel, and effect is significantly better than prior art positive controls.

2, in the miserable test of anti-mouse mobility, compared with comparative example group, give the mouse of the present invention, can significantly suppress the raising (P < 0.05) of the rear lactate level of mouse body motion, extend the walking weight load ((P < 0.05) of mouse; And can obviously reduce the level (P < 0.05) of blood urea nitrogen, significantly strengthen the activity (P < 0.01) of serum lactic dehydrogenase. Result shows, the present invention suppresses lactic acid to produce to having, accelerate lactic acid metabolism, alleviate motion aches sense effect, and effect is significantly better than prior art positive controls.

3, present composition formula is rationally innovated, and production cost is low, technique is simple.

Embodiment

Below by embodiment, the present invention is described further. It is appreciated that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention. The simple modifications that the present invention is carried out by the essence according to the present invention all belongs to the scope of protection of present invention.

Embodiment 1

Take Stem and leaf of Hedyotidous hedyotis 70kg, false 70kg, riparian greenbrier root and rhizome 70kg, root of bidentate achyranthes 70kg, Radix seu Caulis Parabarii 70kg, GUIHUAFU 70kg, leaf of Radix Glycosmidis Citrifoliae 70kg, Sheepear Inula Herb 70kg, Herba Artemisiae Anomalae 70kg, Caulis Bauhihiae Championii 70kg, Root of Tricuspid Cudrania 70kg, Radix Zanthoxyli 70kg, Yunnan Caulis Spatholobi 70kg, Twig and leaf of Common Claoxylon 70kg, Radix Solani indici 70kg, levisticum 70kg, impetuous 70kg, build Cape jasmine 70kg, cloves 35kg, rhizoma cyperi 135kg, Scarlet Kadsura Root 135kg, Small Centipeda Herb 70kg, big Herba Lobeliae Chinensis 70kg, Radix Aconiti Preparata 35kg, Herba Hyperici Japonici 70kg, Semen Momordicae 70kg, the supersound extraction that adds water 2-3 time, doubly, each extraction time is 1-3 hour to the 6-12 that each amount of water is equivalent to medicinal material gross weight, united extraction liquid, filters, and it is the clear cream of 1.05-1.20 that filtrate concentrates to relative density when 60-80 DEG C, takes camphor 2kg, rhizoma atractylodis 70kg, cassia twig 13kg, Flos Ilicis Asprellae 70kg, bee saage 70kg, root of three-nerved spicebush 70kg is placed in micro-powder pulverizer, is crushed into ultrafine powder, ultrafine powder is mixed with clear cream, is dried to dried cream powder, pulverizes, adds supplementary product starch, cane sugar powder, talcum powder, Magnesium Stearate, obtained granule.

Embodiment 2

Take Stem and leaf of Hedyotidous hedyotis 82kg, false 82kg, riparian greenbrier root and rhizome 82kg, root of bidentate achyranthes 82kg, Radix seu Caulis Parabarii 82kg, GUIHUAFU 82kg, leaf of Radix Glycosmidis Citrifoliae 82kg, Sheepear Inula Herb 82kg, Herba Artemisiae Anomalae 82kg, Caulis Bauhihiae Championii 82kg, Root of Tricuspid Cudrania 82kg, Radix Zanthoxyli 82kg, Yunnan Caulis Spatholobi 82kg, Twig and leaf of Common Claoxylon 82kg, Radix Solani indici 82kg, levisticum 82kg, impetuous 82kg, build Cape jasmine 82kg, cloves 42kg, rhizoma cyperi 170kg, Scarlet Kadsura Root 170kg, Small Centipeda Herb 82kg, big Herba Lobeliae Chinensis 82kg, Radix Aconiti Preparata 42kg, Herba Hyperici Japonici 82kg, Semen Momordicae 82kg, the supersound extraction that adds water 2-3 time, doubly, each extraction time is 1-3 hour to the 6-12 that each amount of water is equivalent to medicinal material gross weight, united extraction liquid, filters, and it is the clear cream of 1.05-1.20 that filtrate concentrates to relative density when 60-80 DEG C, takes camphor 5kg, rhizoma atractylodis 82kg, cassia twig 18kg, Flos Ilicis Asprellae 82kg, bee saage 82kg, root of three-nerved spicebush 82kg is placed in micro-powder pulverizer, is crushed into ultrafine powder, ultrafine powder is mixed with clear cream, is dried to dried cream powder, pulverizes, then adds microcrystalline cellulose excipients, hydroxypropylcellulose, sodium starch glycolate, talcum powder, Magnesium Stearate makes tablet.

Embodiment 3

Take Stem and leaf of Hedyotidous hedyotis 76kg, false 76kg, riparian greenbrier root and rhizome 76kg, root of bidentate achyranthes 76kg, Radix seu Caulis Parabarii 76kg, GUIHUAFU 76kg, leaf of Radix Glycosmidis Citrifoliae 76kg, Sheepear Inula Herb 76kg, Herba Artemisiae Anomalae 76kg, Caulis Bauhihiae Championii 76kg, Root of Tricuspid Cudrania 76kg, Radix Zanthoxyli 76kg, Yunnan Caulis Spatholobi 76kg, Twig and leaf of Common Claoxylon 76kg, Radix Solani indici 76kg, levisticum 76kg, impetuous 76kg, build Cape jasmine 76kg, cloves 38kg, rhizoma cyperi 153kg, Scarlet Kadsura Root 153kg, Small Centipeda Herb 76kg, big Herba Lobeliae Chinensis 76kg, Radix Aconiti Preparata 38k, Herba Hyperici Japonici 76kg, Semen Momordicae 76kg, the supersound extraction that adds water 2-3 time, doubly, each extraction time is 1-3 hour to the 6-12 that each amount of water is equivalent to medicinal material gross weight, united extraction liquid, filters, and it is the clear cream of 1.05-1.20 that filtrate concentrates to relative density when 60-80 DEG C, takes camphor 3kg, rhizoma atractylodis 76kg, cassia twig 15kg, Flos Ilicis Asprellae 76kg, bee saage 76kg, root of three-nerved spicebush 76kg is placed in micro-powder pulverizer, is crushed into ultrafine powder, ultrafine powder is mixed with clear cream, is dried to dried cream powder, pulverizes, then adds microcrystalline cellulose excipients, hydroxypropylcellulose, talcum powder, Magnesium Stearate makes capsule.

Pharmacodynamics test: anti-mouse mobility is miserable

1. experiment material

1.1 animal

KM mouse, male, SPF level, body weight 18��22g, 45, purchased from Guangxi Medical University's Experimental Animal Center.

1.2 reagent

Blood urea nitrogen detection kit, Lactic dehydrogenase detection kit, full blood lactic detection kit (Nanjing is built up);

1.3 medicine

Positive drug, embodiment medicine;

2. experimental technique

2.1 groupings, administration, modeling: after experiment mice adaptability raises 3 days, be divided into model control group, embodiment group, positive drug group by animal at random by body weight, often organizes 15. When experiment starts, first giving positive drug group and the corresponding medicine of embodiment treated animal gavage with 20ml/kg dosage, model control group gives physiological saline with same method. Gavage terminates rear 30min, respectively model control group, embodiment group, positive drug group are positioned over water temperature 30 �� 2 DEG C, depth of water 30cm, flow velocity be 0.5m/s flowing tank in carry out 30min swimming training, after swimming terminates, the more corresponding medicine of gavage and physiological saline immediately. 6 days weekly, Sunday had a rest, and continued 2 weeks.

2.2 Indexs measure

2.2.1 the mensuration of mice burden swimming time

15th day, the afterbody model control group, embodiment group, positive drug group mouse negative was equivalent to the weight of body weight 5%, is placed in tank went swimming until power exhausts, and the power standard of exhausting is that mouse head sinks in water, still can not return the water surface through 10s and namely be considered as power and exhaust. The time that record swimming time opening to power exhausts is as the swimming time of mouse.

2.2.2 before mouse movement, in whole blood, lactic acid content measures

Bearing a heavy burden before swimming, eye socket gets whole blood. By the content of lactic acid in the requirement of test kit detection Mouse whole blood

2.2.3 the mensuration of serum lactic dehydrogenase (LDH), blood urea nitrogen (BUN) in lactic acid content, serum in whole blood after mouse movement

After heavy burden swimming terminates, it is put in quiet environment by mouse rest 30min, free diet and drinking-water, has a rest and terminate rear eye socket and get blood. Blood sample is divided into two portions, and a part does not deal with, and after another part blood sample leaves standstill 30min, centrifugal 15 minutes of 4000r/min, gets supernatant and be stored in-20 DEG C of environment stand-by. By serum lactic dehydrogenase (LDH) and BUN in lactic acid, serum in the requirement of test kit detection Mouse whole blood.

3. statistical procedures

The biochemical detection by quantitative result of each group represents with all several �� standard deviations by measurement data, and the variance analysis between each group adopts t inspection. For SPSS13.0, P, < 0.05 thinks that difference has significance in the statistical software used.

4. result

4.1 medicines are on the impact of the walking weight load of mouse

Result is as shown in table 1, compares with model group, and the walking weight load of positive group and embodiment group obviously extends (P < 0.05), has significant difference.

The mice burden swimming time respectively organized by table 1

Note: compare with model group, #P < 0.05, ##P < 0.01.

4.2 medicines are on the impact of the motion Whole blood lactic acid content of mouse

Result is as shown in table 2, compares with model group, and after the motion of positive group and embodiment group, full blood lactic elevation amplitude obviously shortens (P < 0.05), has statistical significance.

Mouse movement Whole blood lactic acid content respectively organized by table 2

Note: compare with model group, #P < 0.05, ##P < 0.01.

4.3 medicines are on the impact of serum urea nitrogen level and lactate dehydrogenase activity after mouse movement

Result is as shown in table 3, compare with model group, the serum urea nitrogen level of positive group and embodiment group significantly declines (P < 0.05), and the activity of serum lactic dehydrogenase then significantly strengthens (P < 0.01).

Table 3 respectively organizes mice serum urea nitrogen levels and lactic dehydrogenase enzyme activity

Note: compare with model group, #P < 0.05, ##P < 0.01.

5. discuss

Blood lactase acid level is an important indicator of reaction body aerobic metabolism ability and organism fatigue degree, the metabolic imbalance in Skeletal Muscle Cell can be made after a large amount of motion, cause body relatively hypoxia and glycolysis-speed to be accelerated, enter and produce a large amount of lactic acid, thus make muscle produce miserable sense. The speed that the reaction of LDH vigor is removed with regard to lactic acid, the raising of LDH activity can accelerate to accumulate in muscle the removing of lactic acid, the elimination accelerated fatigue and slow down the miserable sense of muscle. The product that when BUN is body prolonged exercise, protein metabolism is decomposed, the content of serum BUN can reflect the catabolic situation of nitrogenous substances in body, thus reflects that special conditions lower body is to the load ability to bear of manual work. This experimental result shows, and the present invention can significantly suppress the raising (P < 0.05) of the rear lactate level of mouse body motion, extends the walking weight load ((P < 0.05) of mouse; Meanwhile, can obviously reduce the level (P < 0.05) of blood urea nitrogen, significantly strengthen the activity (P < 0.01) of serum lactic dehydrogenase.

Generally speaking, the present invention can effectively suppress the generation of mouse lactic acid, accelerates the metabolism of lactic acid, thus alleviate and move miserable and improve exercise tolerance.

Conclusion: the present invention can effectively suppress the generation of mouse lactic acid, accelerates the metabolism of lactic acid, thus alleviates and move miserable and improve exercise tolerance.

Although, above with general explanation, embodiment and test, the present invention is described in detail, but on basis of the present invention, it is possible to it being made some modifications or improvements, this will be apparent to those skilled in the art. Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims (5)

1. one kind has the Chinese medicine composition suppressing lactic acid to produce effect, it is characterized in that it is prepared from by the raw material of following weight part: Stem and leaf of Hedyotidous hedyotis 70-82 part, false 70-82 part, riparian greenbrier root and rhizome 70-82 part, root of bidentate achyranthes 70-82 part, Radix seu Caulis Parabarii 70-82 part, GUIHUAFU 70-82 part, leaf of Radix Glycosmidis Citrifoliae 70-82 part, Sheepear Inula Herb 70-82 part, Herba Artemisiae Anomalae 70-82 part, Caulis Bauhihiae Championii 70-82 part, bee saage 70-82 part, Root of Tricuspid Cudrania 70-82 part, Radix Zanthoxyli 70-82 part, Yunnan Caulis Spatholobi 70-82 part, Twig and leaf of Common Claoxylon 70-82 part, Radix Solani indici 70-82 part, levisticum 70-82 part, impetuous 70-82 part, build Cape jasmine 70-82 part, cloves 35-42 part, rhizoma cyperi 135-170 part, Scarlet Kadsura Root 135-170 part, Small Centipeda Herb 70-82 part, root of three-nerved spicebush 70-82 part, big Herba Lobeliae Chinensis 70-82 part, Radix Aconiti Preparata 35-42 part, camphor 2-5 part, Herba Hyperici Japonici 70-82 part, Flos Ilicis Asprellae 70-82 part, Semen Momordicae 70-82 part, rhizoma atractylodis 70-82 part, cassia twig 13-18 part.

2. there is Chinese medicine composition as claimed in claim 1 that suppress lactic acid to produce effect, it is characterized in that it is prepared from by the raw material of following weight part: Stem and leaf of Hedyotidous hedyotis 76 parts, false 76 parts, riparian greenbrier root and rhizome 76 parts, the root of bidentate achyranthes 76 parts, Radix seu Caulis Parabarii 76 parts, GUIHUAFU 76 parts, leaf of Radix Glycosmidis Citrifoliae 76 parts, Sheepear Inula Herb 76 parts, Herba Artemisiae Anomalae 76 parts, Caulis Bauhihiae Championii 76 parts, bee saage 76 parts, Root of Tricuspid Cudrania 76 parts, Radix Zanthoxyli 76 parts, Yunnan Caulis Spatholobi 76 parts, Twig and leaf of Common Claoxylon 76 parts, Radix Solani indici 76 parts, levisticum 76 parts, impetuous 76 parts, build Cape jasmine 76 parts, cloves 38 parts, rhizoma cyperi 153 parts, Scarlet Kadsura Root 153 parts, Small Centipeda Herb 76 parts, the root of three-nerved spicebush 76 parts, big Herba Lobeliae Chinensis 76 parts, Radix Aconiti Preparata 38 parts, camphor 3 parts, Herba Hyperici Japonici 76 parts, Flos Ilicis Asprellae 76 parts, Semen Momordicae 76 parts, rhizoma atractylodis 76 parts, cassia twig 15 parts.

3. there is Chinese medicine composition as claimed in claim 1 or 2 that suppress lactic acid to produce effect, it is characterised in that its activeconstituents adopts water extraction to be prepared from.

4. there is Chinese medicine composition as claimed in claim 3 that suppress lactic acid to produce effect, it is characterized in that its activeconstituents is prepared from by following preparation method: take Stem and leaf of Hedyotidous hedyotis, false, riparian greenbrier root and rhizome, the root of bidentate achyranthes, Radix seu Caulis Parabarii, GUIHUAFU, leaf of Radix Glycosmidis Citrifoliae, Sheepear Inula Herb, Herba Artemisiae Anomalae, Caulis Bauhihiae Championii, Root of Tricuspid Cudrania, Radix Zanthoxyli, Yunnan Caulis Spatholobi, Twig and leaf of Common Claoxylon, Radix Solani indici, levisticum, impetuous, build Cape jasmine, cloves, rhizoma cyperi, Scarlet Kadsura Root, Small Centipeda Herb, big Herba Lobeliae Chinensis, Radix Aconiti Preparata, Herba Hyperici Japonici, Semen Momordicae, the supersound extraction that adds water 2-3 time, each amount of water is equivalent to 6-12 times of medicinal material gross weight, each extraction time is 1-3 hour, united extraction liquid, filter, filtrate concentrate to relative density when 60-80 DEG C be the clear cream of 1.05-1.20, take camphor, rhizoma atractylodis, cassia twig, Flos Ilicis Asprellae, bee saage, the root of three-nerved spicebush, it is crushed into ultrafine powder, ultrafine powder is mixed with clear cream, obtain.

5. there is the Chinese medicine preparation suppressing lactic acid to produce effect, prepare with acceptable carrier in pharmaceutical industries by the Chinese medicine composition suppressing lactic acid to produce effect that has described in claim 1 or 2.