WO2022160981A1

WO2022160981A1 - Traditional chinese medicine skin-scraping medium and preparation method therefor

Info

Publication number: WO2022160981A1
Application number: PCT/CN2021/137782
Authority: WO
Inventors: 马纯政; 马希佳; 程红; 程芳; 李洪霖; 程振洋; 陈梦利; 邵帅; 任娟; 许彦超; 刘亚南; 吴芃
Original assignee: 河南省中医院（河南中医药大学第二附属医院）
Priority date: 2021-01-28
Filing date: 2021-12-14
Publication date: 2022-08-04
Also published as: CN112915142B; CN112915142A; ZA202209444B

Abstract

A traditional Chinese medicine skin-scraping medium and a preparation method therefor. The medium comprises the following active pharmaceutical ingredients in parts by weight: 30-60 parts of acorus gramineus, 20-50 parts of arisaema cum bile, 35-60 parts of polygala tenuifolia, 10-30 parts of valerian, 10-30 parts of coptis chinensis, 20-50 parts of caulis polygoni multiflori, 30-60 parts of semen ziziphi spinosae, 30-60 parts of seman platycladi, 30-50 parts of cortex albiziae, 20-50 parts of angelica sinensis, 20-50 parts of radix astragali, 10-30 parts of bupleuri radix, and 50-80 parts of borneol. The medium is prepared by using a pressurized percolation method, and can improve the sleep quality of an insomnia patient after stroke.

Description

A kind of Chinese medicine scraping medium and preparation method thereof

This application claims the priority of the Chinese patent application with the application number of 202110116491.6 and the invention titled "a Chinese medicine scraping medium and its preparation method" filed with the China Patent Office on January 28, 2021, the entire contents of which are incorporated herein by reference Applying.

technical field

The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine scraping medium and a preparation method thereof.

Background technique

About 85% of post-stroke patients have insomnia or sleep structure disorders such as difficulty falling asleep, waking up easily and dreaming, difficulty falling back to sleep after waking up, headache, and inability to concentrate, which is called post-stroke insomnia. When Western medicine treats insomnia after stroke, it mainly focuses on sedative and soothing, anti-anxiety and antidepressant drugs, which can improve the symptoms of insomnia and restore nerve function by regulating the patient's sleep-wake cycle, thereby promoting the recovery of stroke patients, but long-term use of western medicine is not good More reactions, prone to drug resistance and addiction. A large number of studies have shown that the application of traditional Chinese medicine, acupuncture, massage and other traditional medical methods to treat insomnia after stroke is effective. In particular, scraping therapy can stimulate the relevant acupoints, regulate the neurofeedback mechanism, improve the generation of neurotransmitters in the brain, stimulate the return to normal sleep-wake cycle, and improve the insomnia symptoms of patients in a short period of time. However, there are few studies on the use of scraping combined with traditional Chinese medicine in the treatment of post-stroke insomnia.

SUMMARY OF THE INVENTION

In view of this, the purpose of the present invention is to provide a traditional Chinese medicine scraping medium that can significantly improve the sleep quality of insomnia patients after stroke, and can improve the insomnia symptoms of patients in a short period of time.

In order to achieve the above-mentioned purpose of the invention, the present invention provides the following technical solutions:

The invention provides a traditional Chinese medicine scraping medium, which comprises the following raw materials in parts by weight: 30-60 parts of calamus, 20-50 parts of Dannanxing, 35-60 parts of Polygala, 10-30 parts of valerian, huanglian 10-30 parts, 20-50 parts of Shouwu Teng, 30-60 parts of Suanzao Ren, 30-60 parts of Bai Ziren, 30-50 parts of Albizia Julibrissin, 20-50 parts of Angelica sinensis, 20-50 parts of Astragalus, Bupleurum 10- 30 servings, 50-80 servings of borneol.

Preferably, when scraping with the Chinese medicine scraping medium, the steps of scraping and wiping the upper back acupoints of the Governor Vessel and the Bladder Meridian of Foot Taiyang are included.

The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine scraping medium, comprising the following steps: pulverizing the raw materials of the traditional Chinese medicine scraping medium except borneol, sieving, and mixing and soaking with an ethanol solution with a volume fraction of 85%-95% , the soaked medicinal powder is subjected to pressure and heavy osmosis to obtain osmotic liquid, the alcohol concentration of the osmotic liquid is adjusted to 45%-50% with water, and borneol is added to obtain the osmotic liquid.

Preferably, during the soaking, the dosage of the ethanol solution is 3-5 times the total dosage of the scraping medium except the borneol.

Preferably, the sieving is specifically passing through a 10-30 mesh sieve.

Preferably, the soaking time is 24-48h.

Preferably, the specific steps of the pressurized re-osmosis are as follows: according to the method of laying a layer of medicinal powder and compacting it once, into the percolation cylinder in stages, after the medicinal powder layer is laid, add ethanol with a volume fraction of 85%-95% The solution did not cover the medicinal powder layer, soaked for 36-48 hours, pressurized to obtain a percolating liquid, put the percolating liquid into the percolating cylinder again, and repeated the above steps of soaking and pressurizing the medicinal powder layer until the alcohol concentration of the obtained percolating liquid was 75 -85%.

Preferably, when the ethanol solution with a volume fraction of 85%-95% is added to cover the powder layer, the height of the ethanol solution in the percolation cylinder is 2-5 times the height of the powder layer.

Preferably, after the percolation liquid is put into the percolation cylinder, an ethanol solution with a volume fraction of 85%-95% is added so that the height of the liquid in the percolation cylinder is 2-5 times the height of the powder layer.

Preferably, the pressing pressure is 5-8 kpa/cm ² .

Beneficial effects of the present invention:

In the traditional Chinese medicine scraping medium of the present invention, Shichangpu and Dannanxing are the king drugs, and the main functions are to clear away heat and resolve phlegm, relieve wind and calm panic, and on the basis of removing dampness, removing phlegm, and dispelling filth, it also has the functions of reviving the senses, rejuvenating the mind, calming the mind and improving wisdom. power, play a leading role. Yuanzhi is bitter, bitter and warm in nature, good in nature, cathartic and accessible, happy and calming the heart and mind; Valerian is sedative and soothing, and its alcohol extract can increase the sleep time of barbiturates, and can significantly expand coronary blood vessels; Boziren and Suanzaoren are both sweet in taste and flat in nature. It has obvious effect of restoring physical strength; both the water decoction and alcohol extract of Albizia Julibrissin can prolong the sleep time of sodium pentobarbital in mice; the alcoholic extract of Shouwu Teng is often used with Albizia julibrissin, Suanzaoren, Baiziren and other nourishing and soothing drugs. It is the main medicine to improve sleep by regulating the sleep-wake mechanism of stroke patients. Astragalus and Angelica tonify qi and tonify deficiency, and when qi travels, blood circulates, and has the effect of accelerating blood circulation in the patient's brain. Modern pharmacological studies have shown that astragalus can significantly expand peripheral blood vessels and improve microcirculation. , which can effectively relieve the anxiety of patients, and quickly enter a deep sleep state as an adjuvant. The combination of various medicines plays the role of removing phlegm and calming shock, nourishing qi and activating blood, nourishing heart and soothing liver, and calming the mind. Borneol is a transdermal agent. In this recipe, alcohol and borneol not only exert their own functions of dredging blood vessels and promoting medicinal potential, but also through scraping therapy, they can also use the operation of meridians to strengthen the tightness and continuity between the medicine and the contact site. The active ingredients of the drug can directly enter the blood through the skin, and directly reach the lesion under the dual action of the drug and the meridian effect, which has a multiplier effect on the treatment of post-stroke insomnia.

For the first time, the present invention adopts the treatment method of scraping with traditional Chinese medicine osmotic luo liquid as the scraping medium, and the scraping liquid prepared by applying pressure and heavy osmotic lubricating traditional Chinese medicine technology has a remarkable effect in improving insomnia after cerebral apoplexy, and can improve the insomnia symptoms of patients in a short period of time. , and the preparation process is convenient, the operation is simple, the cost is low, and the patients are easy to accept.

Detailed ways

Preferably, it includes the following raw materials in parts by weight: 40-50 parts of Shichangpu, 25-40 parts of Dannanxing, 40-55 parts of Yuanzhi, 12-25 parts of Valerian, 15-25 parts of Huanglian, Shouwu 25-40 parts of rattan, 40-50 parts of Suanzaoren, 40-50 parts of Baiziren, 35-45 parts of Albizia Julibrissin, 25-40 parts of Angelica, 25-45 parts of Astragalus, 15-25 parts of Bupleurum, 60-70 parts of Borneo share.

The present invention does not specifically limit the sources of the above-mentioned medicinal flavors, and conventional commercially available products in the field can be used. In the present invention, Shichangpu and Dannanxing are the monarch medicines, Polygala Radix, Valerian, Boziren, Suanzaoren, Acacia bark and Shouwuteng are the minister medicines, and Astragalus, Angelica sinensis and Bupleurum are adjuvants. The combination of various medicines plays the role of removing phlegm and calming shock, nourishing qi and activating blood, nourishing heart and soothing liver, and calming the mind. As a transdermal agent, borneol not only exerts its own functions of dredging blood vessels and promoting medicinal potential, but also through scraping therapy, it can also use the operation of meridians to strengthen the tightness and continuity between the drug and the contact site, so that the active ingredients of the drug can pass through the skin. It directly enters the blood, and directly reaches the lesion under the dual action of drugs and meridian effects, which has a multiplier effect on the treatment of post-stroke insomnia.

The invention also provides a preparation method of the above-mentioned traditional Chinese medicine scraping medium, comprising the following steps: pulverizing the components of the traditional Chinese medicine scraping medium except borneol, sieving, mixing and soaking with an ethanol solution with a volume fraction of 85%-95% , the soaked medicinal powder is subjected to pressure and heavy osmosis to obtain osmotic liquid, the alcohol concentration of the osmotic liquid is adjusted to 45%-50% with water, and borneol is added to obtain the osmotic liquid.

The present invention does not specifically limit the specific method of pulverization, and the pulverization method of conventional Chinese medicinal materials in the field can be used. The sieving of the present invention is preferably a 10-30 mesh sieve, more preferably a 20-mesh sieve, the powder is too fine and easy to block the filling opening, and the coarse Chinese medicine powder is not easy to be compacted. The present invention has no special requirements for the source of the ethanol solution, and conventional commercial products in the field can be used. During the soaking, the dosage of the ethanol solution is preferably 3-5 times the total dosage of the scraping medium except the borneol, more preferably 4 times, the soaking time is preferably 24-48h, more preferably 30-42h, the limit of the amount of ethanol solution and soaking time of the present invention can fully expand the medicinal material. In the present invention, the water for adjusting the alcohol concentration of the leachate is not particularly limited, and it is preferably sterilized distilled water.

The specific steps of the pressurized and re-osmotic rolling according to the present invention are preferably as follows: according to the method of laying a layer of medicinal powder and compacting it once, it is loaded into the percolating cylinder in stages, and after the medicinal powder layer is laid, add ethanol with a volume fraction of 85% to 95% The solution did not cover the medicinal powder layer, soaked for 36-48 hours, pressurized to obtain a percolating liquid, put the percolating liquid into the percolating cylinder again, and repeated the above steps of soaking and pressurizing the medicinal powder layer until the alcohol concentration of the obtained percolating liquid was 75 -85%.

In the percolation cylinder of the present invention, the bottom of the percolation cylinder preferably contains a filter material, and the filter material is not particularly limited in the present invention, preferably degreased gauze, and the number of layers of the degreased gauze is preferably 4-6 layers, More preferably, it is 5 layers. According to the method of laying a layer of medicinal powder and compacting once, all the medicinal powders are put into the percolation cylinder, and then the ethanol solution with a volume fraction of 85%-95% is added to cover the medicinal powder layer and soaked. The height of the ethanol solution is preferably 2-5 times the height of the medicinal powder layer, more preferably 3-4 times the height of the medicinal powder layer, and the soaking time is preferably 40-44 hours. After soaking, pressurize to obtain a leachate, and the pressure of the pressurization is preferably 5-8kpa/cm ² , more preferably 6-7kpa/cm ² , so that the leachate is filtered at a speed of 1-3ml/min faster material to obtain the first leachate. Put the collected first percolation liquid into the percolation cylinder again, add an ethanol solution with a volume fraction of 85%-95% so that the height of the liquid in the percolation cylinder is 2-5 times the height of the powder layer, repeat the above soaking, adding Pressing step, wherein soaking time, percolation pressure, percolation flow rate are all the same as the first percolation process, to obtain the second percolation liquid, and so on, until the alcohol concentration of the obtained percolation liquid is determined to be between 75-85 %, more preferably between 78-82% to stop percolation. The pressurized and heavy percolation method adopted in the present invention is equivalent to multiple dipping, has high leaching efficiency, and can retain the effective components of the medicine to the maximum extent.

When the Chinese medicine scraping medium of the present invention is used for scraping treatment of stroke patients, it preferably includes scraping and wiping the upper back acupoints of the Du meridian and the bladder meridian of Foot Taiyang. In a preferred embodiment of the present invention, the use method of the above-mentioned Chinese medicine scraping medium comprises the following steps:

Apply the scraping medium to the scraping area, form a certain angle between the scraping plate and the skin, take the elbow joint as the axis, and make a one-way regular movement along the direction of the Du meridian and the bladder meridian of Foot Taiyang, and the movement range is within 3-7cm. The frequency is 80-100 times/min. The angle is preferably 45°, the movement range is preferably within 6 cm, and the frequency is preferably 90 times/min.

When using the traditional Chinese medicine scraping medium of the present invention for scraping, it is preferable to scrape the head first, press the Baihui point as the center for 5 minutes, then scrape in the direction of Sishencong point, scrape forward to the front hairline, scrape backward To below the occipital tuberosity, the technique is from light to heavy, scraping for 18-20 minutes; then scraping the neck, firstly use Fengfu point, Dazhui point, Taodao point and other governor channels to scrape along the axis of behavior for 8-10 minutes, then Scrape the upper left side of the Taiyang Bladder Meridian from Tianzhu to Dazhu and Fufen for 8-10 minutes, and then scrape the right Tianzhu to Dazhu and Fufen in this way, taking Sha as the degree ; Finally, scrape the neck and shoulders: This is the part where the gallbladder meridian of Foot Shaoyang circulates, along the left and right Fengchi points to Jianjing points, scraping and wiping on both sides for 8-10 minutes, taking Sha as the degree. During the scraping process, if there is local soreness, numbness, swelling and pain, etc., you can press the corresponding parts for 20-30 times. After the scraping is over, pay attention to the skin condition. The symptoms of scalding are red, purple, black spots or black blisters on the surface of the skin.

The invention focuses on the scraping therapy of scraping the Governor Vessel and the upper back acupoints of the bladder meridian of Foot Taiyang, which can effectively improve sleep. The Du meridian and the bladder meridian of Foot Taiyang are the "sea of yang meridians" in the human body. The Shangbeishu points are closely related to the zang-fu organs and are the hubs for the qi and blood of the zang-fu organs to infuse the whole body. effect. Yao points Sishencong, Baihui, Fengfu, Dazhui, Taodao, Tianzhu, Dashu, Fufen and other points can increase the content of inhibitory neurotransmitters serotonin and γ-aminobutyric acid in the brain, reduce The content of the excitatory neurotransmitter norepinephrine, which can improve sleep quality and prolong sleep time

The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the protection scope of the present invention.

Example 1

(1) Weigh 30g of calamus, 20g of Dannanxing, 35g of Polygala radix, 10g of Valerian, 10g of Huanglian, 20g of Shouwuteng, 30g of Suanzaoren, 30g of Boziren, 30g of Acacia Bark, 20g of Angelica, 20g of Astragalus, 10g of Bupleurum , respectively crushed and passed through a 10-mesh sieve, mixed, and soaked in 795 g of 95% ethanol for 24 hours to obtain swelling powder.

(2) 5 layers of degreased gauze are laid at the bottom of the percolation cylinder as a filter material, and the expanded medicinal powder is loaded into the percolation cylinder in stages according to the method of laying one layer of medicinal powder and compacted once, and the medicinal powder layer is evenly spread 3cm each time, and the medicinal powder layer is laid After finishing, add 95% ethanol to cover 10cm of the medicinal material, add pressure of 5kpa/cm ² after soaking for 36 hours, open the outlet at the lower end of the percolation cylinder, and make the leachate pass through the filter material at a speed of 1ml/min.

(3) After the percolation is completed, put the collected percolation liquid into the percolation cylinder again, add 95% ethanol solution so that the height of the liquid in the percolation cylinder is less than 10cm of the medicinal material, and perform secondary immersion and pressurization. After soaking for 36 hours Add a pressure of 5kpa/cm ² , open the outlet at the lower end of the percolation cylinder, and make the leachate pass through the filter material at a speed of 1ml/min.

(4) Repeat step (3) until the alcohol concentration of the percolating liquid is between 75-85%, stop percolating, adjust the alcohol content with sterilized distilled water, make the alcohol content of the percolating liquid reach 45%, add 50g borneol, melted and sealed for later use.

Example 2

(1) Weigh 60g of calamus, 50g of Dannanxing, 60g of Polygala, 30g of Valerian, 30g of Huanglian, 50g of Shouwuteng, 60g of Suanzaoren, 60g of Boziren, 50g of Acacia peel, 50g of Angelica, 50g of Astragalus, 30g of Bupleurum , respectively crushed and passed through a 30-mesh sieve, mixed, and soaked in 2900 g of 95% ethanol for 48 hours to obtain swelling powder.

(2) 5 layers of degreased gauze are laid at the bottom of the percolation cylinder as a filter material, and the expanded medicinal powder is loaded into the percolation cylinder in stages according to the method of laying a layer of medicinal powder and compacted once, and the medicinal powder layer is evenly spread 5cm each time, and the medicinal powder layer is laid After completion, add 85% ethanol to cover 15cm of the medicinal material, add pressure of 8kpa/ ^cm2 after soaking for 48h, open the outlet at the lower end of the percolation cylinder, and make the leaching solution pass through the filter material at a speed of 3ml/min.

(3) After the percolation is completed, put the collected percolation liquid into the percolation cylinder again, add 85% ethanol solution so that the height of the liquid in the percolation cylinder is less than 15cm of the medicinal material, and perform secondary immersion and pressurization. After soaking for 48 hours Add a pressure of 8kpa/cm ² , open the outlet at the lower end of the percolation cylinder, and make the leachate pass through the filter material at a speed of 3ml/min.

(4) Repeat step (3) until the alcohol concentration of the percolating liquid is between 75-85%, stop percolating, adjust the alcohol content with sterilized distilled water, make the alcohol content of the percolating liquid reach 50%, add 80g borneol, melted and sealed for later use.

Example 3

(1) Weigh 45g of calamus, 30g of Dannanxing, 45g of Polygalaceae, 15g of Valerian root, 20g of Huanglian, 30g of Shouwuteng, 45g of Suanzaoren, 45g of Boziren, 40g of Acacia bark, 30g of Angelica sinensis, 30g of Astragalus, 20g of Bupleurum , respectively crushed and passed through a 20-mesh sieve, mixed, and soaked in 1580 g of 95% ethanol for 35 hours to obtain swelling powder.

(2) 5 layers of degreased gauze are laid at the bottom of the percolation cylinder as a filter material, and the expanded medicinal powder is loaded into the percolation cylinder in stages according to the method of laying a layer of medicinal powder and compacted once. After finishing, add 95% ethanol to cover 12cm of the medicinal material, add pressure of 6kpa/ ^cm2 after soaking for 40h, open the outlet at the lower end of the percolation cylinder, and make the leachate pass through the filter material at a speed of 2ml/min.

(3) After the percolation is completed, put the collected percolation liquid into the percolation cylinder again, add 95% ethanol solution so that the height of the liquid in the percolation cylinder is less than 12cm of the medicinal material, and perform secondary immersion and pressurization. After soaking for 40 hours Add a pressure of 6kpa/cm ² , open the outlet at the lower end of the percolation cylinder, and make the leachate pass through the filter material at a speed of 2ml/min.

(4) Repeat step (3) until the alcohol concentration of the percolating liquid is between 75-85%, stop percolating, adjust the alcohol content with sterilized distilled water, make the alcohol content of the percolating liquid reach 47%, add 70g borneol, melted and sealed for later use.

Example 4

clinical information

A total of 88 patients who were diagnosed with stroke in the Rehabilitation Department of the Second Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2019 to May 2020 were selected as the research objects, and were randomly divided into the experimental group and the control group according to the random number table method. The experimental group was the Chinese medicine medium scraping treatment group, and the control group was the scraping treatment group. There were 43 patients in each group, and 2 patients withdrew halfway. The experimental group consisted of 25 males and 18 females with an average age of (53.21±2.37) years; the control group, 21 males and 22 females, with an average age of (54.36±1.68) years. There was no significant difference (P>0.05) between the two groups of patients in terms of age, gender, disease condition, and course of disease, and they were comparable.

Diagnostic criteria

It conforms to the diagnostic criteria for stroke formulated by the "Guidelines for the Prevention and Treatment of Cerebrovascular Diseases in China"; and conforms to the diagnostic criteria for insomnia in the "Guidelines for the Diagnosis and Treatment of Insomnia in Chinese Adults" formulated by the Sleep Disorders Group of the Neurology Branch of the Chinese Medical Association in 2012.

Inclusion criteria

Insomnia occurred after stroke; stroke 30 days ≤ disease duration ≤ 180 days; Pittsburgh Sleep Quality Index (PSQI) score ≥ 7; patients did not take related sedative drugs within 14 days; subjects and their families gave informed consent to participate and signed informed consent consent.

Exclusion criteria

Patients with severe cognitive impairment; mental illness; severe infection; malignant hypertension; severe insufficiency of vital organs such as the heart and kidney; allergic constitution; patients with sleep apnea and hypopnea.

Both groups of patients received symptomatic treatment in accordance with the guidelines for stroke treatment, including control of blood pressure, blood sugar, and blood lipids, application of nutritive nerves, drugs to improve circulation, and basic rehabilitation training.

Control group: On the basis of symptomatic treatment, scraping therapy was added, and the medium used in scraping was emollient oil.

Test group: the medium used in scraping was the traditional Chinese medicine scraping medium of the present invention, and the others were the same as the control group.

Both the control group and the experimental group used the following scraping methods:

The patient sits in a sitting position, exposes the shoulders and neck, takes an appropriate amount of scraping medium (skin oil) and places it on the scraping site, spreads it evenly with a scraping board, holds the scraping board with one hand, the angle between the scraping board and the skin is about 45°, and the elbow The joint is the axis, and the one-way regular movement is performed along the direction of the Du meridian and the bladder meridian of the foot sun. The movement range is within 5cm, and the frequency is about 90 times/min. Scrape the head first: fix the patient's head, press Baihui acupoint as the center for five minutes, then scrape in the direction of Sishencong acupoint, scrape forward to the anterior hairline, and scrape backward to below the occipital tuberosity. From light to heavy, it is normal for the patient to have scalp fever after scraping for 20 minutes. Scrape the neck again: firstly use Fengfu, Dazhui, Taodao and other Du meridians to scrape the central axis of the behavior for 8 minutes, then scrape the upper left side of the Taiyang Bladder Meridian from Tianzhu to Dazhao and Fufen , Scrape for 8 minutes, in this way, scrape the right Tianzhu point to Dazhu point and Fufen point, and take the Sha as the degree. Finally, scrape the neck and shoulders: This is the part where the Gallbladder Meridian of Foot Shaoyang circulates, along the left and right Fengchi acupoints to Jianjing acupoints, and scrape each side for 8 minutes, taking Sha as the degree. During the scraping process, if local feeling of soreness, numbness, swelling and pain occurs, apply pressure on the corresponding part 20 times. After the scraping is over, pay attention to the skin condition. The symptoms of shaving are red, purple, black spots or black blisters on the surface of the skin.

Observation Indicator

Pittsburgh Sleep Quality Index Scale (PSQI)

Observe the changes of PSQI scores in the two groups before and after treatment to evaluate the sleep quality of the patients, including sleep disorders, hypnotic drugs, sleep onset time, sleep time, sleep efficiency, subjective sleep quality, and daytime function, with a total score of 0-21. The higher the total score, the worse the sleep quality of the patient.

Efficacy criteria

Recovery: return to normal sleep time or sleep time at night > 6h, deep sleep, full of energy after waking up, PSQI reduction rate ≥ 75%;

Markedly effective: significantly improved sleep, sleep time increased by more than 3 hours, sleep depth increased, 50%≤PSQI score reduction rate <75%;

Effective: the symptoms are relieved, the sleep time is increased by <3h, and the reduction rate of 25%≤PSQI score is <50%;

Invalid: If insomnia does not improve or worsens after treatment, the PSQI score reduction rate is less than or equal to 25%.

Total effective rate = (number of cured cases + number of markedly effective cases + number of effective cases)/total number of cases × 100%.

SPSS 22.0 statistical software was used to process the obtained data, and the scores were

The t test was performed between groups; the total effective rate of treatment was expressed in %, and the χ ² test was performed between groups, and P<0.05 was considered statistically significant.

The results are shown in Tables 1 and 2:

Table 1 Comparison of total PSQI scores between the two groups before and after treatment and one month follow-up

Table 2 Comparison of curative effects before and after treatment in the two groups [cases (%)]

From Table 1, before treatment, there was no significant difference in PSQI score between the two groups (P=0.111). After treatment, the PSQI score of the experimental group was (10.34±1.50) lower than that of the control group (9.11±1.97). , the difference was statistically significant (P<0.05). It can be seen from Table 2 that the total effective rate of treatment in the experimental group was 95.35%, which was significantly higher than that in the control group, 81.40%, and the difference was statistically significant (P=0.044). Both Tables 1 and 2 show that the method of using the traditional Chinese medicine leachate of the present invention as a scraping medium can significantly improve the sleep quality of patients.

In addition, it can also be seen from Table 1 and Table 2 that simply applying the scraping operation method of the present invention can improve sleep, the reason is that: the head is the meeting of all yang and the sect of a hundred veins, and scraping the head can dredge the air Blood, balance yin and yang, adjust the function of viscera, scraping Baihui and Sishencong can help them to calm down and sleep. The Beishu acupoint on the bladder meridian of Foot Taiyang is also the hub for the viscera and blood to be transfused into the whole body. After scraping, it can not only dredge the blood and relieve cerebral vasospasm, but also improve the sleep latency (SL) and the number of awakenings (AT) of the patient. and sleep efficiency (SE), increasing the levels of inhibitory neurotransmitters serotonin and gamma-aminobutyric acid in the brain, thereby improving sleep quality.

It shows that the scraping medium prepared by the pressurized re-osmosis method can improve the curative effect again. The reason is that: the preparation method using the pressurized re-osmosis method has the advantages of complete extraction, not easy to destroy active ingredients, and energy saving. In the preparation process, ethanol is used as a common extraction solvent, which can maximize the effective ingredients of more than a dozen traditional Chinese medicines. extracted. As a transdermal agent, borneol is given a clear explanation in "Materia Medica Yanyi": "If you walk alone, you will be weak, but if you are accompanied by an envoy, you will be successful." Therefore, in this prescription, alcohol and borneol not only play their own functions of dredging blood vessels and promoting medicinal potential, but also through scraping therapy, they can also use the operation of meridians to strengthen the closeness and continuity between the medicine and the contact site, and make the active ingredients of the medicine more effective. It directly enters the bloodstream through the skin, and directly reaches the lesion under the dual action of drugs and meridian effects, which has a multiplier effect on the treatment of post-stroke insomnia.

The above are only the preferred embodiments of the present invention. It should be pointed out that for those skilled in the art, without departing from the principles of the present invention, several improvements and modifications can be made. It should be regarded as the protection scope of the present invention.

Claims

A traditional Chinese medicine scraping medium, characterized in that, the traditional Chinese medicine scraping medium comprises the following raw materials in parts by weight: 30-60 parts of Shichangpu, 20-50 parts of Dannanxing, 35-60 parts of Polygala Radix, 10-60 parts of Valeriana officinalis 30 parts, 10-30 parts Huanglian, 20-50 parts Shouwu Teng, 30-60 parts Suanzaoren, 30-60 parts Boziren, 30-50 parts Acacia peel, 20-50 parts Angelica, 20-50 parts Astragalus , Bupleurum 10-30 copies, borneol 50-80 copies.
The traditional Chinese medicine scraping medium according to claim 1, characterized in that, when scraping with the traditional Chinese medicine scraping medium, the steps of scraping and wiping the upper back acupoints of the Governor Vessel and the Bladder Meridian of Foot-Taiyang are included.
The preparation method of the traditional Chinese medicine scraping medium according to any one of claims 1-2, characterized in that it comprises the steps of: crushing and sieving the raw materials of the traditional Chinese medicine scraping medium except borneol, with a volume fraction of 85%-95% % ethanol solution is mixed and soaked, and the soaked medicinal powder is subjected to pressure and re-osmosis to obtain a osmotic fluid, and the alcohol concentration of the osmotic fluid is adjusted to 45%-50% with water, and borneol is added to obtain the osmotic fluid.
The preparation method according to claim 3, characterized in that, during the soaking, the consumption of the ethanol solution is 3-5 times the total consumption of the scraping medium except borneol.
The preparation method according to claim 3, wherein the sieving is specifically a 10-30 mesh sieve.
The preparation method according to claim 3, wherein the soaking time is 24-48h.
The preparation method according to claim 3, characterized in that, the specific steps of the pressurized re-percolation are: according to the method of laying a layer of medicinal powder and compacting it once, into the percolating cylinder in stages, after the medicinal powder layer is laid, adding The ethanol solution with a volume fraction of 85%-95% has not passed the powder layer, soaked for 36-48h, and pressurized to obtain a percolation liquid, put the percolation liquid into the percolation cylinder again, and repeat the above steps of soaking and pressurizing the powder layer until The alcohol concentration of the obtained leachate is 75-85%.
The preparation method according to claim 7, wherein when the ethanol solution with a volume fraction of 85%-95% is added to cover the powder layer, the height of the ethanol solution in the percolation cylinder is 2-5 times the height of the powder layer.
The preparation method according to claim 7, characterized in that, after the percolation liquid is put into the percolation cylinder, an ethanol solution with a volume fraction of 85%-95% is added to make the height of the liquid in the percolation cylinder equal to the height of the powder layer. 2-5 times.
The preparation method according to claim 3, wherein the pressing pressure is 5-8 kpa/cm 2 .