CN104857414A - Medicine composite for treating chronic simple rhinitis - Google Patents

Abstract

Disclosed is a medicine composite for treating chronic simple rhinitis. The medicine composite is composed of raw materials such as ramulus cinnamomi, radix angelicae, fructus forsythiae, dandelion, flos magnoliae, ligusticum wallichii, spica prunellae, astragalus membranaceus, fructus aurantii, polygonum cuspidatum, periostracum cicada, human placenta, salviae miltiorrhizae, round cardamom, liquidambar formosana hance, manyprickle acanthopanax roots, leonurus, asarum, flos carthami, houttuynia cordata, folium ginkgo, gentiana macrophylla, agastache rugosus, fructus lycii, semen plantaginis, hairyvein agrimony, poria cocos, endothelium corneum gigeriae galli, radix paeoniae rubra, rhizoma acori graminei and liquorice. Compatibility of the medicine composite conforms to the principle of 'monarch, minister, assistant and guide' of traditional Chinese medicine, the preparation is simple and convenient, the medicinal herbs resource is wide, costs are low, the toxicity is small, the medicine composite can operate quickly, the price is low, side effects are absent, and the safety is high.

Description

A kind of pharmaceutical composition for the treatment of chronic simple rhinitis

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of pharmaceutical composition for the treatment of chronic simple rhinitis.

Background technology

Rhinitis refers to the inflammation of nasal membrane and submucous tissue.Show as hyperemia or edema, patient often there will be nasal obstruction, and stream clear water tears, rhinocnesmus, throat is uncomfortable, the symptoms such as cough.The wash sample material of nasal secretions is called nasal mucus or nasal secretion, and its effect helps dust out, and antibacterial is to keep the health of pulmonary.Under normal circumstances, be drawn to throat after the nasal mucus of mixed cell and dust and finally enter gastric, because its secretory volume is little, generally can not attract much attention.When inflammation appears in intranasal, nasal cavity can secrete a large amount of nasal mucus, and can because of infection yellowing, can cough be caused when flowing through throat, can also flow out through prenaris when nasal mucus amount is very many.Acute and chronic rhinitis is China's commonly encountered diseases and frequently-occurring disease, and according to the literature, cacorhinia incidence rate fluctuation in various places is between 10.7-44.5%, especially in southern various places, have a humid climate, sickness rate is very high, and wherein 76% is occur in less than 30 years old, 6.4% is had between 40-50 year, within 50 years old, only have 1% or 2%, this course of disease is long, easily repeatedly later, Chang Yin, with symptoms such as headache, dizziness, hypomnesis, brings adverse effect to patient.

The sickness rate of rhinitis is in obviously increasing trend, and its sickness rate is 10 ~ 20% according to statistics, in recent years the sickness rate of rhinitis especially with annual 3 ~ 5% speed increment.Medical circle analysis and research result display: the upgrading of environmental pollution and the decline of air quality are the immediate causes causing rhinitis sickness rate to increase.Be suspended in the toxic gas such as motor vehicle exhaust emission thing, incineration of garbage thing, industrial production waste gas thing in the environment that we depend on for existence, and each bacterioid, dust etc., all the time all enter in nasal cavity in the breathing with people, once have an opportunity, these nuisances will grow in nasal cavity gathering, cause inflammation.People must breathe, and one breathes, and virus, antibacterial, anaphylactogen will enter with breathing, without any under the safeguard procedures protection of correspondence, must cause rhinitis, even can recurrent exerbation.

Chronic rhinitis is common continuing more than 4 weeks or chronic inflammatory disease under the nasal mucosa of inflammation recurrent exerbation and mucosa.Some general diseases as: anemia, tuberculosis, diabetes can cause the long-term blood stasis of nasal mucosa or reflexive congested; Acute rhinitis is prolonged not to heal, and deviation of nasal septum, sinusitis all can impel nasal mucosa vasomotoricity generation obstacle, causes nasal mucosa plump congested." chronic rhinitis " belongs to the traditional Chinese medical science " stuffy nose " sick category, and this name of disease head sees " the large opinion of Plain Questions 5 constant virtues political affairs ": " Great Heat, with row, is coughed and sneezes, stuffy nose." " Liu's interchannel medical science book series etiology based on plain questions " roll up one and say: " stuffy nose is stopped up also." add: " but upper orifices tonneau of lying on one's side, and occlusion of the lower orifices." indicate the cardinal symptom feature of stuffy nose." Jing Yue's complete work volume 27 " is pointed out: " mostly how fiery Chang Saizhe is, and sudden and violent plug person is windy cold, when as distinguishing." " Zhang Shi doctor is logical " speech: " sudden and violent rising is cold, strongly fragrant one-tenth heat of a specified duration." sudden and violent play a person and refer to " cold nasal obstruction ", " strongly fragrant for a long time " person refers to chronic nasal obstruction.

Chronic rhinitis can divide chronic simple rhinitis and chronic hypertrophic rhinitis, chronic simple rhinitis and chronic hypertrophic rhinitis are two stages of a disease, chronic simple rhinitis on pathology in chronic hypertrophic rhinitis conversion process without clear and definite boundary, and often had degree type to exist.

Chronic simple rhinitis is the reversibility diseases associated with inflammation of a kind of nasal mucosa caused by local, whole body or environmental resistance factor, the pathological characteristic of chronic simple rhinitis is: due to neural blood vessel dysfunction, nasal mucosa deep layer arteriovenous chronic dilatation, there is swelling in concha nasalis, but shallow-layer blood vessel is not obviously expanded, have lymphocyte and plasmocyte infiltrating around blood vessel and body of gland, mucous gland function is enlivened, secretions increase, but mucous membrane tissue is without obvious hypertrophy.

The clinical manifestation of chronic simple rhinitis is mainly intermittence or alternately has a stuffy nose, a little mucus or purulence nasal mucus, headache, olfactory disorder, concha nasalis inferior swelling, smooth surface are moistening, in kermesinus, the soft high resilience of mucosa, can occur depression with probe compressing, remove probe and restore to the original state immediately, this disease can cause patient's giddy, headache so that affect the mental status.

Chronic simple rhinitis is a kind of reversibility disease, along with the development of urban industry, in city, air quality constantly declines, day by day increasing the weight of of atmospheric pollution, various atmosphere pollution and dust cause sustain deleterious sexual stimulus to bronchia mucosal, cause chronic simple rhinitis sickness rate to rise gradually, therefore, the treatment of this disease is more and more subject to people's attention.

The analysis of chronic rhinitis biopsy pathology is one of the important means of the diagnosis of doctor trained in Western medicine chronic rhinitis, treatment and judging prognosis, treatment is main adopts the method such as medicine topical therapeutic, operative treatment, laser therapy, electric rubbing hot medicated compress, micro-wave therapeutic, liquid nitrogen cryotherapy, radio-frequency (RF) therapy, and curative effect is significantly improved more in the past.Although primary disease Western medicine diagnose is clear and definite, treatment has also been made significant headway, but the method majority adopted can destroy the normal physiological structure of nasal cavity, and adopt Western medicine topical therapeutic late result can not be satisfactory, easy generation drug resistance and toxic and side effects, expensive, easily there is the problems such as the reaction of medicamentous rhinitis, systemic toxicity profiles, arrhythmia in the local Western medicine 1% nitrofural ephedrine nasal drop as conventional.

According to theory of Chinese medical science, " healthy energy deposit in, heresy can not be done "; " gathering of heresy, its gas must be empty ".Chronic rhinitis is main stagnant based on positive exogenous pathogen in early days, and the later stage is based on blood stasis.If use the clinical manifestation of theory of Chinese medical science to chronic simple rhinitis and chronic hypertrophic rhinitis to carry out dialectical, be equivalent to the asthenia of pulmonosplenic qi of the traditional Chinese medical science, evil stagnant nose key respectively and heresy poison is stayed for a long time, stagnation of QI blood cave amphitypy, syndrome of deficiency of QI and chronic simple rhinitis relation the closest, pathological change also more shows as chronic rhinitis early changes, describes the early stage of syndrome of deficiency of QI pathological changes many genus chronic rhinitis from pathologic angle.As everyone knows, in motherland's medical science, Chinese medicine ingredients wide material sources, cost is low, have no side effect, in alternative Western medicine, have unique advantage, especially relative to the Western medicine medication of existing local, it is little that treatment by Chinese herbs rhinitis has toxicity, instant effect, low price, has no drug resistance, the significant advantage that safety is high.

Summary of the invention

The present invention is directed to weak point of the prior art, provide a kind of pharmaceutical composition for the treatment of chronic simple rhinitis, relative to therapies such as doctor trained in Western medicine operations, it has can not destroy the normal physiological structure of nasal cavity, good effect, instant effect, preparation is simple, low price, and the advantage such as have no side effect.

Above-mentioned purpose of the present invention is realized by following technical proposals:

Treat a pharmaceutical composition for chronic simple rhinitis, the crude drug of described pharmaceutical composition is made up of Ramulus Cinnamomi, the Radix Angelicae Dahuricae, Fructus Forsythiae, Herba Taraxaci, Flos Magnoliae, Rhizoma Chuanxiong, Spica Prunellae, the Radix Astragali, Fructus Aurantii, Rhizoma Polygoni Cuspidati, Periostracum Cicadae, Placenta Hominis, Radix Salviae Miltiorrhizae, Fructus Amomi Rotundus, Fructus Liquidambaris, Radix Et Caulis Acanthopanacis Senticosi, Herba Leonuri, Herba Asari, Flos Carthami, Herba Houttuyniae, Folium Ginkgo, Radix Gentianae Macrophyllae, Herba Pogostemonis, Fructus Lycii, Semen Plantaginis, Herba Agrimoniae, Poria, Endothelium Corneum Gigeriae Galli, Radix Paeoniae Rubra, Rhizoma Acori Graminei, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 12-20 part, Radix Angelicae Dahuricae 10-16 part, Herba Houttuyniae 3-8 part, Fructus Forsythiae 5-12 part, Flos Magnoliae 12-17 part, Herba Taraxaci 7-12 part, Flos Carthami 4-9 part, Radix Astragali 15-20 part, Fructus Aurantii 10-15 part, Rhizoma Polygoni Cuspidati 8-12 part, Placenta Hominis 2-5 part, Spica Prunellae 3-7 part, Radix Salviae Miltiorrhizae 11-14 part, Fructus Amomi Rotundus 9-15 part, Rhizoma Chuanxiong 3-6 part, Fructus Liquidambaris 8-13 part, Herba Leonuri 3-5 part, Herba Asari 1-3 part, Folium Ginkgo 5-10 part, Herba Pogostemonis 5-10 part, Radix Gentianae Macrophyllae 13-16 part, Fructus Lycii 3-10 part, Semen Plantaginis 8-13 part, Herba Agrimoniae 3-5 part, Radix Et Caulis Acanthopanacis Senticosi 1-3 part, Periostracum Cicadae 5-10 part, Poria 3-6 part, Endothelium Corneum Gigeriae Galli 8-13 part, Radix Paeoniae Rubra 3-5 part, Rhizoma Acori Graminei 11-16 part, Radix Glycyrrhizae 8-12 part.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 12 parts, the Radix Angelicae Dahuricae 16 parts, Herba Houttuyniae 3 parts, Fructus Forsythiae 12 parts, Flos Magnoliae 12 parts, Herba Taraxaci 10 parts, 9 parts, Flos Carthami, the Radix Astragali 15 parts, Fructus Aurantii 15 parts, Rhizoma Polygoni Cuspidati 8 parts, Placenta Hominis 5 parts, Spica Prunellae 3 parts, Radix Salviae Miltiorrhizae 14 parts, 9 parts, Fructus Amomi Rotundus, Rhizoma Chuanxiong 6 parts, Fructus Liquidambaris 8 parts, Herba Leonuri 5 parts, Herba Asari 1 part, Folium Ginkgo 10 parts, Herba Pogostemonis 5 parts, Radix Gentianae Macrophyllae 16 parts, Fructus Lycii 10 parts, Semen Plantaginis 8 parts, Herba Agrimoniae 5 parts, Radix Et Caulis Acanthopanacis Senticosi 1 part, Periostracum Cicadae 10 parts, 6 parts, Poria, Endothelium Corneum Gigeriae Galli 8 parts, Radix Paeoniae Rubra 3 parts, Rhizoma Acori Graminei 11 parts, 10 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 20 parts, the Radix Angelicae Dahuricae 10 parts, Herba Houttuyniae 8 parts, Fructus Forsythiae 5 parts, Flos Magnoliae 17 parts, Herba Taraxaci 12 parts, 4 parts, Flos Carthami, the Radix Astragali 20 parts, Fructus Aurantii 10 parts, Rhizoma Polygoni Cuspidati 12 parts, Placenta Hominis 2 parts, Spica Prunellae 7 parts, Radix Salviae Miltiorrhizae 11 parts, 15 parts, Fructus Amomi Rotundus, Rhizoma Chuanxiong 3 parts, Fructus Liquidambaris 13 parts, Herba Leonuri 3 parts, Herba Asari 3 parts, Folium Ginkgo 5 parts, Herba Pogostemonis 10 parts, Radix Gentianae Macrophyllae 13 parts, Fructus Lycii 3 parts, Semen Plantaginis 13 parts, Herba Agrimoniae 3 parts, Radix Et Caulis Acanthopanacis Senticosi 3 parts, Periostracum Cicadae 5 parts, 4 parts, Poria, Endothelium Corneum Gigeriae Galli 10 parts, Radix Paeoniae Rubra 4 parts, Rhizoma Acori Graminei 16 parts, 12 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 13 parts, the Radix Angelicae Dahuricae 11 parts, Herba Houttuyniae 4 parts, Fructus Forsythiae 6 parts, Flos Magnoliae 13 parts, Herba Taraxaci 7 parts, 5 parts, Flos Carthami, the Radix Astragali 18 parts, Fructus Aurantii 11 parts, Rhizoma Polygoni Cuspidati 9 parts, Placenta Hominis 4 parts, Spica Prunellae 6 parts, Radix Salviae Miltiorrhizae 12 parts, 13 parts, Fructus Amomi Rotundus, Rhizoma Chuanxiong 4 parts, Fructus Liquidambaris 9 parts, Herba Leonuri 4 parts, Herba Asari 2 parts, Folium Ginkgo 6 parts, Herba Pogostemonis 6 parts, Radix Gentianae Macrophyllae 14 parts, Fructus Lycii 5 parts, Semen Plantaginis 10 parts, Herba Agrimoniae 4 parts, Radix Et Caulis Acanthopanacis Senticosi 2 parts, Periostracum Cicadae 6 parts, 5 parts, Poria, Endothelium Corneum Gigeriae Galli 12 parts, Radix Paeoniae Rubra 3 parts, Rhizoma Acori Graminei 12 parts, 8 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 17 parts, the Radix Angelicae Dahuricae 15 parts, Herba Houttuyniae 7 parts, Fructus Forsythiae 11 parts, Flos Magnoliae 16 parts, Herba Taraxaci 8 parts, 8 parts, Flos Carthami, the Radix Astragali 16 parts, Fructus Aurantii 14 parts, Rhizoma Polygoni Cuspidati 11 parts, Placenta Hominis 3 parts, Spica Prunellae 5 parts, Radix Salviae Miltiorrhizae 13 parts, 14 parts, Fructus Amomi Rotundus, Rhizoma Chuanxiong 5 parts, Fructus Liquidambaris 12 parts, Herba Leonuri 3 parts, Herba Asari 1 part, Folium Ginkgo 10 parts, Herba Pogostemonis 9 parts, Radix Gentianae Macrophyllae 13 parts, Fructus Lycii 7 parts, Semen Plantaginis 11 parts, Herba Agrimoniae 3 parts, Radix Et Caulis Acanthopanacis Senticosi 1 part, Periostracum Cicadae 10 parts, 4 parts, Poria, Endothelium Corneum Gigeriae Galli 11 parts, Radix Paeoniae Rubra 4 parts, Rhizoma Acori Graminei 15 parts, 9 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 15 parts, the Radix Angelicae Dahuricae 12 parts, Herba Houttuyniae 5 parts, Fructus Forsythiae 9 parts, Flos Magnoliae 15 parts, Herba Taraxaci 9 parts, 7 parts, Flos Carthami, the Radix Astragali 19 parts, Fructus Aurantii 13 parts, Rhizoma Polygoni Cuspidati 10 parts, Placenta Hominis 4 parts, Spica Prunellae 4 parts, Radix Salviae Miltiorrhizae 11 parts, 11 parts, Fructus Amomi Rotundus, Rhizoma Chuanxiong 5 parts, Fructus Liquidambaris 10 parts, Herba Leonuri 5 parts, Herba Asari 3 parts, Folium Ginkgo 8 parts, Herba Pogostemonis 8 parts, Radix Gentianae Macrophyllae 14 parts, Fructus Lycii 9 parts, Semen Plantaginis 12 parts, Herba Agrimoniae 5 parts, Radix Et Caulis Acanthopanacis Senticosi 3 parts, Periostracum Cicadae 8 parts, 6 parts, Poria, Endothelium Corneum Gigeriae Galli 9 parts, Radix Paeoniae Rubra 5 parts, Rhizoma Acori Graminei 14 parts, Radix Glycyrrhizae 8-12 part.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 19 parts, the Radix Angelicae Dahuricae 14 parts, Herba Houttuyniae 6 parts, Fructus Forsythiae 7 parts, Flos Magnoliae 14 parts, Herba Taraxaci 9 parts, 6 parts, Flos Carthami, the Radix Astragali 17 parts, Fructus Aurantii 13 parts, Rhizoma Polygoni Cuspidati 10 parts, Placenta Hominis 4 parts, Spica Prunellae 4 parts, Radix Salviae Miltiorrhizae 11 parts, 11 parts, Fructus Amomi Rotundus, Rhizoma Chuanxiong 5 parts, Fructus Liquidambaris 10 parts, Herba Leonuri 5 parts, Herba Asari 3 parts, Folium Ginkgo 8 parts, Herba Pogostemonis 8 parts, Radix Gentianae Macrophyllae 14 parts, Fructus Lycii 4 parts, Semen Plantaginis 9 parts, Herba Agrimoniae 5 parts, Radix Et Caulis Acanthopanacis Senticosi 3 parts, Periostracum Cicadae 8 parts, 3 parts, Poria, Endothelium Corneum Gigeriae Galli 8 parts, Radix Paeoniae Rubra 5 parts, Rhizoma Acori Graminei 13 parts, 11 parts, Radix Glycyrrhizae.

Further, described Chinese medicine composition is prepared according to following method:

(1) get each medical material of components by weight percent in arbitrary described pharmaceutical composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1-2 hour: second time adds the water of 8-12 times amount, decocts 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) pulverized by dry extract obtained for step (2), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (2) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (2) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (2) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

The invention still further relates to the application of a kind of described pharmaceutical composition in treatment chronic simple rhinitis medicine.

The pharmaceutical composition for the treatment of chronic simple rhinitis provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Fructus Aurantii: bitter in the mouth, pungent, sour, warm in nature.Return spleen, stomach warp.Function cures mainly: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus." property of medicine opinion ": control rubella all over, dislikes as numb bean in flesh and itches, main hemorrhoidal hamorrhage haemorrhoids, stagnation of QI in chest and abdomen, and the swollen void of two sides of body, pass diaphragm is congested." Japan hanako materia medica ": spleen benefiting and stimulating the appetite, adjust the five internal organs, the therapeutic method to keep the adverse QI flowing downwards, preventing or arresting vomiting is inverse, expectorant.Control regurgitation, cholera dysentery, helps digestion, and broken crux mass beside the umbilicus, five types of dysphagia, except wind improving eyesight and lung qi edema, sharp intestine and small intestine, skin is itched.Swollen can the processing of hemorrhoid is pressed." pearl sac ": dispelling the stagnated QI, lets out gas unfavorable in lung." medicine origin ": " curing mainly secret formula " cloud, broken hardness in the epigastrium painful abdominal mass, profit is gas in the heart, reduces phlegm, and helps digestion.

Herba Leonuri: acrid-sweet flavor, feeble QI temperature, nontoxic.Enter the heart, liver, urinary bladder channel.Invigorate blood circulation, blood stasis dispelling, regulating menstruation, disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converge with speech ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or blood is tired of bruise, and coma in silence; Or lochia robs the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth does not fall, dead fetus in the uterus, be all just before giving birth all cards, non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood room, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are amassed, or the overworked and swollen routed uneasiness of skin infection pain, be the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, there are inhibition thrombosis, antiinflammatory, analgesic effect, there is the vasoconstrictive effect eliminating epinephrine, norepinephrine, have " tonneau passages through which vital energy circulates " to act on.

The Radix Angelicae Dahuricae: acrid in the mouth is warm in nature, returns lung, stomach, large intestine channel, the cold expelling that induces sweat, wind-expelling pain-stopping, dampness leukorrhagia stopping, detumescence and apocenosis; The modern pharmacological research Radix Angelicae Dahuricae has the significantly effect such as antipyretic, antiinflammatory, analgesia, suppression smooth muscle contraction;

Fructus Forsythiae: bitter in the mouth, cold nature.There is heat-clearing and toxic substances removing, effect of dispersing swelling and dissipating binds, for carbuncle, anemopyretic cold.Warmly to join the army, high hot excessive thirst.

Flos Magnoliae: acrid in the mouth, warm in nature, enter lung, stomach warp; there is effect of expelling wind and cold, understand things pain-stopping, cure mainly headche due to wind-cold, dizzy; nasal sinusitis, nose cold current tears, toothache; the cards such as swelling of the face, Flos Magnoliae merit is apt to lung qi dispersing gas and clearing the nasal passage, is the special medicine for the treatment of nasal sinusitis; pharmacological action shows as protection nasal mucosa, promotes that mucosal secretions absorbs, reduces inflammation; short nasal cavity is unobstructed, antiallergic, anti-dopamine.

Spica Prunellae: bitter in the mouth; Pungent; Cold in nature.Return liver; Gallbladder meridian.Liver heat removing and eyesight improving; Powder detoxifcation.Cure mainly corneal nebula photophobia; Ophthalmalgia; Have a headache dizzy; Tinnitus; Scrofula; Goiter; Acute mastitis; Mumps; Carbuncle furuncle and phyma poison; Acute, chronic hepatitis; Hypertension." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " liver-wind of dispelling, network of passing through.Control facial hemiparalysis, row irritability, opens stagnation of liver-QI, only bones and muscles pain, ophthal malgia, loose scrofula, whole body tuberculosis." modern medicine study confirmation, Spica Prunellae has significant blood pressure lowering and antibacterial action.

The Radix Astragali: latin name Astragali Radix, sweet in the mouth, warm in nature, enter spleen, lung meridian, there is tonification spleen soil, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, effect of holder skin ulcer granulation promoting, cures mainly the weak anorexia and loose stool that deficiency of both the splenic and pulmonary QI is caused, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.

The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian.Function heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, addiction abdominal mass, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus." medical center bun will " carries it: hard kidney, strong Yang yi Jing, strengthening bone and muscle, increases strength.Apply to get injured by a fall and lose place, can reunion of fractured tendons and bones.

Periostracum Cicadae: sweet in the mouth, cold in nature.Return lung, Liver Channel.Function cures mainly: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus." not Lu ": main children's's epilepsy; The main chronic dysentery of ash clothes." property of medicine opinion ": control children's's high fever infantile convulsion from head to foot, doublely can quench the thirst." detailed outline ": control phlegm-accumulating vertigo, skin wind heat, varioliform exanthema is had an itch, tetanus and treatment toxic swelling skin ulcer, and adult's aphonia, children's's lockjaw sky hangs, frightened night cry of crying, swelling of the vulva.

Ramulus Cinnamomi acrid-sweet flavor, warm in nature, it is the interior temperature medicine that interior cold is commonly used, there is effect of complement sun, ventilation quality, promoting blood circulation, warming the spleen and stomach, normal and invigorating the liver and kidney medicine, fill blood medicine compatibility, treatment insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, treat coldness and pain in the epigastrium, arthralgia due to cold lumbago with other drugs for dispelling internal cold compatibility, has the effect of significantly analgesia and anti-cancer and cancer-preventing.

Placenta Hominis: sweet, salty, warm, mend, feel at ease to nourish blood, QI invigorating, benefit essence, removing toxic substances etc., cure mainly deficient, weakness and emaciation, hemoptysis asthma, consumptive fever hectic fever due to YIN-deficiency, seminal emission etc.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, GUIXIN, Liver Channel, have promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, and clear away heart-fire relieving restlessness, and effect of nourishing blood to tranquillize the mind, cures mainly menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, and skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the cards such as angina pectoris.

Fructus Amomi Rotundus: latin name Amomi Fructus Rotundus, acrid in the mouth, warm in nature, return lung, stomach, spleen channel, there is removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, effect of appetite-stimulating indigestion-relieving, cures mainly turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, the cards such as chest and abdomen swelling and pain.

Rhizoma Chuanxiong: acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel, have blood-activating and qi-promoting, effect of wind-expelling pain-stopping, cures mainly menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; The cards such as ulcer sores.

Fructus Liquidambaris is bitter, flat.Return liver, kidney channel.Function cures mainly: dispelling, collateral-activating, and diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.

Radix Et Caulis Acanthopanacis Senticosi: latin name Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.

Herba Taraxaci: be feverfew Herba Taraxaci Taraxacum mongolicum Hand.-Mazz., alkali ground Herba Taraxaci Taraxacumsinicum Kitag. or the dry herb belonging to several plants together.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For treating pyogenic infections from tumour or sore, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Herba Asari: nature and flavor are pungent, warm; Effect: dispel the wind, cold expelling, row water, has one's ideas straightened out.Herba Asari can outer dispersing wind and cold, again can in dispel YIN-cold, pain relieving simultaneously.

Radix Glycyrrhizae: latin name Glycyrrhizae Radix et Rhizoma, sweet in the mouth, property put down, enter 12 warps, have heat-clearing and toxic substances removing, be in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.

Herba Houttuyniae: acrid in the mouth, cold nature, enters lung, urinary bladder channel, has heat-clearing and toxic substances removing, removing pus and relieving carbuncle, effect of inducing diuresis for treating stranguria syndrome, and for lung abscess vomiting pus, expectorant heat syndrome cough is breathed heavily, toxic-heat and blood stasis, damp-heat gonorrhoea, pyretic toxicity carbuncle sore, and snakeworm wants first-class card.

Folium Ginkgo: function cures mainly: relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving, for cough and asthma due to lung deficiency, coronary heart diseases and angina pectoris, hyperlipidemia.

Radix Gentianae Macrophyllae, toil, flat.Enter liver, stomach, gallbladder meridian.Function cures mainly: expelling wind and removing dampness, and blood relaxing muscles and tendons, clearing away heat and promoting diuresis.Dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, jaundice, has blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.

Herba Pogostemonis, pungent, tepor.As lung, spleen, stomach warp.Function cures mainly: fast gas, and in, ward off dirty, damp eliminating, cure cold heat-damp in summer, cold and heat, and headache, breast wrist painful abdominal mass is vexed, and vomiting is had loose bowels, malaria, dysentery, halitosis.

Structure Qi, sweet, flat.Return liver, kidney channel.Nourishing the liver and kidney, beneficial intensive culture blood, improving eyesight removing nebula, nourishing the lung to arrest cough.Cure mainly the atrophic debility of bones of suffering from a deficiency of the kidney, impotence and seminal emission, fertility of a specified duration, senilism senilism, early whitening of beard and hair, blood deficiency and yellow complexion, the diseases such as puerperal, breast was few, poor vision, interior external oculopathy eye, and interior-heat is quenched one's thirst, consumptive fever hectic fever due to YIN-deficiency, and chronic consumptive disease is coughed, the few expectorant of dry cough.

Semen Plantaginis: clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.

Herba Agrimoniae: latin name Agrimoniae Herba, bitter in the mouth, puckery, property is put down, GUIXIN, Liver Channel, there is astringing to arrest bleeding, effect of dysentery relieving parasite killing, cure mainly various hemorrhage card, such as: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage.

Poria: sweet in the mouth, light, property is put down, and GUIXIN, spleen, kidney channel, have diuresis, immunomodulating, and hepatoprotective strengthening the spleen and stomach antitumor toxin expelling is antibacterial, promotes hemopoietic function, calmly waits effect, can be used for anhydrating swollen, insufficiency of the spleen diarrhoea, tranquilizing soporific.

Rhizoma Acori Graminei: pungent, bitter, temperature.GUIXIN, stomach warp.Effect with cure mainly: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, the insane disease of coma, forgetful deafness.

Endothelium Corneum Gigeriae Galli, property is sweet, flat, returns spleen, stomach, small intestinal, urinary bladder channel, has effect of strengthening the spleen to promote digestion, only incontinence of urine, the inducing decomposition of calculi, is mainly used in food stagnation and does not disappear, vomiting dysentery, infantile malnutrition etc.

Radix Paeoniae Rubra: bitter, is slightly cold.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Radix Paeoniae Rubra can purify the blood a point excess-heat, and dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between is for use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, can purify the blood a point excess-heat, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis.

In theory of Chinese medical science, chronic simple rhinitis belongs to " stuffy nose " category, think that chronic simple rhinitis mostly is outside wind and cold wind heat and attack, harmony is stagnant in lung, lung opening at nose, the heresy of cold and heat is attacked in nose, causes key clearly unfavorable, raw in turbid tears.From the angle of medicine typing, chronic simple rhinitis belongs to asthenia of pulmonosplenic qi type, and its pathogenesis loses in medical treatment or recurrent exerbation for cold nasal obstruction, protracted course of disease, and the gas defended of prolonged illness consumption impairing the lung, causes insufficiency of lung-QI, and evil poison is detained nose key; Or eating and drinking without temperance, overstrain, lose after being ill and support, impairing the spleen and stomach, causes weakness of the spleen and stomach, and transporting is lost strong, and turbid damp is detained nose key and is disease.The traditional Chinese medical science thinks that nose is key outside lung, lung opening at nose, and lung qi plentifully then breathes tonneau, rhinitis, its source of disease of sinusitis at " lung ", due to pathogenic heat volt lung, lung-heat does not go out or wind and cold violates lung, causes " water wet " to stagnate nose key, cause the smooth or nasal mucus of edematous turbinates, ventilation constantly, the disease such as sneeze.

Why chronic simple rhinitis is easy to recurrent exerbation, and delay is difficult, often because of spleen lung virtual loss, and weakened defensive QI, nose key is easily hindered by air-cooled, so that stops up obstructed, therefore, treatment should be basic with the conditioning of spleen lung, in pharmaceutical composition of the present invention, and Fructus Forsythiae, Spica Prunellae, Herba Taraxaci powder detoxifcation, Rhizoma Polygoni Cuspidati heat-clearing and toxic substances removing, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, Herba Houttuyniae heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome, Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain is monarch drug.Turbid and the clearing the nasal passage of Flos Magnoliae, the Radix Angelicae Dahuricae, Herba Asari energy dispersing wind and cold, removing dampness, Fructus Amomi Rotundus, Rhizoma Chuanxiong removing dampness circulation of qi promoting, Fructus Liquidambaris dispelling, collateral-activating, diuretic stimulates the menstrual flow, expelling wind and removing dampness, Herba Agrimoniae astringing to arrest bleeding, dysentery relieving parasite killing, Radix Gentianae Macrophyllae expelling wind and removing dampness, with blood relaxing muscles and tendons, clearing away heat and promoting diuresis, the fast gas of Herba Pogostemonis, with in, ward off dirty, damp eliminating, Semen Plantaginis clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, Poria diuresis, immunomodulating, monarch drug assisted by all medicines, is ministerial drug in side.Herba Leonuri is invigorated blood circulation, blood stasis dispelling, regulating menstruation, and disappear water, Flos Carthami, Radix Salviae Miltiorrhizae are invigorated blood circulation latus rectum, eliminating stasis to stop pain, Folium Ginkgo blood circulation promoting and blood stasis dispelling, pain relieving, and Periostracum Cicadae falls apart wind heat extraction, Radix Astragali tonification spleen soil, elevate a turnable ladder yang-energy, Fructus Aurantii regulating the flow of QI to ease the stomach, the stagnant relieving distension of row, Radix Et Caulis Acanthopanacis Senticosi replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, Fructus Lycii nourishing the liver and kidney, beneficial intensive culture blood, Rhizoma Acori Graminei, Endothelium Corneum Gigeriae Galli removing dampness appetizing, to have one's ideas straightened out eliminating phlegm, refreshment Fructus Alpiniae Oxyphyllae, adjuvant drug in all medicine sides of being, bone and muscle strengthening, strengthening the spleen and stomach, improves immunity.Ramulus Cinnamomi complement sun, ventilation quality, promoting blood circulation, Placenta Hominis feels at ease to nourish blood, QI invigorating, benefit essence, removing toxic substances, Radix Glycyrrhizae heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, for making medicine.All medicines share, and play effect of blood circulation promoting and blood stasis dispelling, anti-inflammation, inducing diuresis to remove edema altogether.

The pharmaceutical composition compatibility for the treatment of chronic simple rhinitis of the present invention meets Chinese medicine " monarch " principle, prepares easy, and medicine source is extensive, and toxicity with low cost is little, instant effect, and low price has no side effect, and safety is high.

Detailed description of the invention

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.

Embodiment 1:

A kind of pharmaceutical composition for the treatment of chronic simple rhinitis of the present invention, get following traditional Chinese medicine raw medicine: Ramulus Cinnamomi 12 grams, the Radix Angelicae Dahuricae 16 grams, Herba Houttuyniae 3 grams, Fructus Forsythiae 12 grams, Flos Magnoliae 12 grams, Herba Taraxaci 10 grams, 9 grams, Flos Carthami, the Radix Astragali 15 grams, Fructus Aurantii 15 grams, Rhizoma Polygoni Cuspidati 8 grams, Placenta Hominis 5 grams, Spica Prunellae 3 grams, Radix Salviae Miltiorrhizae 14 grams, 9 grams, Fructus Amomi Rotundus, Rhizoma Chuanxiong 6 grams, Fructus Liquidambaris 8 grams, Herba Leonuri 5 grams, Herba Asari 1 gram, Folium Ginkgo 10 grams, Herba Pogostemonis 5 grams, Radix Gentianae Macrophyllae 16 grams, Fructus Lycii 10 grams, Semen Plantaginis 8 grams, Herba Agrimoniae 5 grams, Radix Et Caulis Acanthopanacis Senticosi 1 gram, Periostracum Cicadae 10 grams, 6 grams, Poria, Endothelium Corneum Gigeriae Galli 8 grams, Radix Paeoniae Rubra 3 grams, Rhizoma Acori Graminei 11 grams, 10 grams, Radix Glycyrrhizae.

The preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1 hour: second time adds the water of 8 times amount, decocts 1h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24 hours, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) pulverized by dry extract obtained for step (2), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule.

Embodiment 2:

A kind of pharmaceutical composition for the treatment of chronic simple rhinitis of the present invention, get following traditional Chinese medicine raw medicine: Ramulus Cinnamomi 20 grams, the Radix Angelicae Dahuricae 10 grams, Herba Houttuyniae 8 grams, Fructus Forsythiae 5 grams, Flos Magnoliae 17 grams, Herba Taraxaci 12 grams, 4 grams, Flos Carthami, the Radix Astragali 20 grams, Fructus Aurantii 10 grams, Rhizoma Polygoni Cuspidati 12 grams, Placenta Hominis 2 grams, Spica Prunellae 7 grams, Radix Salviae Miltiorrhizae 11 grams, 15 grams, Fructus Amomi Rotundus, Rhizoma Chuanxiong 3 grams, Fructus Liquidambaris 13 grams, Herba Leonuri 3 grams, Herba Asari 3 grams, Folium Ginkgo 5 grams, Herba Pogostemonis 10 grams, Radix Gentianae Macrophyllae 13 grams, Fructus Lycii 3 grams, Semen Plantaginis 13 grams, Herba Agrimoniae 3 grams, Radix Et Caulis Acanthopanacis Senticosi 3 grams, Periostracum Cicadae 5 grams, 4 grams, Poria, Endothelium Corneum Gigeriae Galli 10 grams, Radix Paeoniae Rubra 4 grams, Rhizoma Acori Graminei 16 grams, 12 grams, Radix Glycyrrhizae.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1-2 hour: second time adds the water of 12 times amount, decocts 1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) dry extract that step (2) is obtained be dry, pulverize, make powder.

Embodiment 3:

A kind of pharmaceutical composition for the treatment of chronic simple rhinitis of the present invention, get following traditional Chinese medicine raw medicine: Ramulus Cinnamomi 13 grams, the Radix Angelicae Dahuricae 11 grams, Herba Houttuyniae 4 grams, Fructus Forsythiae 6 grams, Flos Magnoliae 13 grams, Herba Taraxaci 7 grams, 5 grams, Flos Carthami, the Radix Astragali 18 grams, Fructus Aurantii 11 grams, Rhizoma Polygoni Cuspidati 9 grams, Placenta Hominis 4 grams, Spica Prunellae 6 grams, Radix Salviae Miltiorrhizae 12 grams, 13 grams, Fructus Amomi Rotundus, Rhizoma Chuanxiong 4 grams, Fructus Liquidambaris 9 grams, Herba Leonuri 4 grams, Herba Asari 2 grams, Folium Ginkgo 6 grams, Herba Pogostemonis 6 grams, Radix Gentianae Macrophyllae 14 grams, Fructus Lycii 5 grams, Semen Plantaginis 10 grams, Herba Agrimoniae 4 grams, Radix Et Caulis Acanthopanacis Senticosi 2 grams, Periostracum Cicadae 6 grams, 5 grams, Poria, Endothelium Corneum Gigeriae Galli 12 grams, Radix Paeoniae Rubra 3 grams, Rhizoma Acori Graminei 12 grams, 8 grams, Radix Glycyrrhizae.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1-2 hour: second time adds the water of 8-12 times amount, decocts 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.15;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 48 hours, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) dry extract obtained for step (2) is pulverized, add appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.

Embodiment 4:

A kind of pharmaceutical composition for the treatment of chronic simple rhinitis of the present invention, get following traditional Chinese medicine raw medicine: Ramulus Cinnamomi 17 grams, the Radix Angelicae Dahuricae 15 grams, Herba Houttuyniae 7 grams, Fructus Forsythiae 11 grams, Flos Magnoliae 16 grams, Herba Taraxaci 8 grams, 8 grams, Flos Carthami, the Radix Astragali 16 grams, Fructus Aurantii 14 grams, Rhizoma Polygoni Cuspidati 11 grams, Placenta Hominis 3 grams, Spica Prunellae 5 grams, Radix Salviae Miltiorrhizae 13 grams, 14 grams, Fructus Amomi Rotundus, Rhizoma Chuanxiong 5 grams, Fructus Liquidambaris 12 grams, Herba Leonuri 3 grams, Herba Asari 1 gram, Folium Ginkgo 10 grams, Herba Pogostemonis 9 grams, Radix Gentianae Macrophyllae 13 grams, Fructus Lycii 7 grams, Semen Plantaginis 11 grams, Herba Agrimoniae 3 grams, Radix Et Caulis Acanthopanacis Senticosi 1 gram, Periostracum Cicadae 10 grams, 4 grams, Poria, Endothelium Corneum Gigeriae Galli 11 grams, Radix Paeoniae Rubra 4 grams, Rhizoma Acori Graminei 15 grams, 9 grams, Radix Glycyrrhizae.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the water boiling and extraction adding 15 times of medical material gross weight, decocts 1-2 hour: second time adds the water of 8-12 times amount, decocts 1-1.2h, leaches medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) dry extract obtained for step (2) is pulverized, add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.

Embodiment 5:

A kind of pharmaceutical composition for the treatment of chronic simple rhinitis of the present invention, get following traditional Chinese medicine raw medicine: Ramulus Cinnamomi 15 grams, the Radix Angelicae Dahuricae 12 grams, Herba Houttuyniae 5 grams, Fructus Forsythiae 9 grams, Flos Magnoliae 15 grams, Herba Taraxaci 9 grams, 7 grams, Flos Carthami, the Radix Astragali 19 grams, Fructus Aurantii 13 grams, Rhizoma Polygoni Cuspidati 10 grams, Placenta Hominis 4 grams, Spica Prunellae 4 grams, Radix Salviae Miltiorrhizae 11 grams, 11 grams, Fructus Amomi Rotundus, Rhizoma Chuanxiong 5 grams, Fructus Liquidambaris 10 grams, Herba Leonuri 5 grams, Herba Asari 3 grams, Folium Ginkgo 8 grams, Herba Pogostemonis 8 grams, Radix Gentianae Macrophyllae 14 grams, Fructus Lycii 9 grams, Semen Plantaginis 12 grams, Herba Agrimoniae 5 grams, Radix Et Caulis Acanthopanacis Senticosi 3 grams, Periostracum Cicadae 8 grams, 6 grams, Poria, Endothelium Corneum Gigeriae Galli 9 grams, Radix Paeoniae Rubra 5 grams, Rhizoma Acori Graminei 14 grams, Radix Glycyrrhizae 8-12 gram.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1.5 hours: second time adds the water of 8 times amount, decocts 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

Embodiment 6:

A kind of pharmaceutical composition for the treatment of chronic simple rhinitis of the present invention, get following traditional Chinese medicine raw medicine: Ramulus Cinnamomi 19 grams, the Radix Angelicae Dahuricae 14 grams, Herba Houttuyniae 6 grams, Fructus Forsythiae 7 grams, Flos Magnoliae 14 grams, Herba Taraxaci 9 grams, 6 grams, Flos Carthami, the Radix Astragali 17 grams, Fructus Aurantii 13 grams, Rhizoma Polygoni Cuspidati 10 grams, Placenta Hominis 4 grams, Spica Prunellae 4 grams, Radix Salviae Miltiorrhizae 11 grams, 11 grams, Fructus Amomi Rotundus, Rhizoma Chuanxiong 5 grams, Fructus Liquidambaris 10 grams, Herba Leonuri 5 grams, Herba Asari 3 grams, Folium Ginkgo 8 grams, Herba Pogostemonis 8 grams, Radix Gentianae Macrophyllae 14 grams, Fructus Lycii 4 grams, Semen Plantaginis 9 grams, Herba Agrimoniae 5 grams, Radix Et Caulis Acanthopanacis Senticosi 3 grams, Periostracum Cicadae 8 grams, 3 grams, Poria, Endothelium Corneum Gigeriae Galli 8 grams, Radix Paeoniae Rubra 5 grams, Rhizoma Acori Graminei 13 grams, 11 grams, Radix Glycyrrhizae.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1.2 hours: second time adds the water of 8-12 times amount, decocts 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

Acute toxicity test:

Get mice 40, body weight 20-25 gram, be divided into 2 groups at random by body weight, treatment group and matched group: treatment group takes granule prepared by the embodiment of the present invention 4, and 0.43ml/10g body weight gastric infusion is pressed in fasting after 12 hours, dose 0.45g/ml, matched group takes distilled water, three times on the one, to observation post administration 14 days, none was dead for mice, main organs no abnormality seen, also have no other obviously abnormal, within the 14th day, put to death and cut open inspection some animals, perusal main organs no abnormality seen.

Six months long term toxicity tests: weigh weekly once during administration, every day claims appetite, without dead or moribund animals, result mice hair color is bright and clean, and behavioral activity, glandular secretion, breathing, feces character are all normal.Pathologic finding is pointed out, to various internal organs without obvious drug-induced pathological change.

Clinical reasoning:

In order to verify the effect of pharmaceutical composition of the present invention, in May ,-2014 in October, 2012, chronic simple rhinitis patient 180 example is randomly drawed in outpatient service place, random digits table is adopted to be divided into treatment group and matched group at random, wherein treatment group 90 example, male 39 example, women 51 example, 22 ~ 65 years old age; Matched group 90 example, male 40 example, women 50 example, 21 ~ 68 years old age.2 groups of sexes, age, courses of disease etc. compare, and difference there are no significant meaning (P > 0.05), has comparability.

Diagnostic criteria

Doctor trained in Western medicine standard: according to national Teaching Materials at College level " ENT & HN Surgery Dept. ": 1. nasal obstruction is for intermittent and/or alternately; 2. watery nasal discharge is mucus, and amount is many; 3. and/or with dry pharynx, pharyngalgia; 4. and/or with headache, dizzy; 5. bronchia mucosal is congested; 6. concha nasalis inferior edema, kermesinus, smooth surface, softness, flexible, responsive to Decongestant; 7. secretions is sticky, is positioned at the bottom of nasal cavity, inferior nasal meatus or meatus nasi communis.

Traditional Chinese medical science standard: syndrome of deficiency of QI, primary symptom: 1. alternately have a stuffy nose; Heavy time light when 2. having a stuffy nose.Secondary disease: 1. flow rare tears, increases the weight of when meeting cold; 2. the micro-swollen discomfort of head; 3. pale tongue with white fur; 4. thready and weak pulse.Diagnosis: all possess primary symptom one, and secondary disease two persons can be diagnosed as this card.

Severity Scaling standard: adopt integration method, the situation of change of itemized record severe extent.1. feelings recurrent exerbation number of times: show effect every half a year 1 time 2 points; Every 3 months 1 time 4 points; Every 2 months 1 time 6 points; Every 1 month more than 1 time or 1 time 8 points.2. have a stuffy nose: without obviously having a stuffy nose 0 point; Nasal obstruction for intermittent, alternately 4 points.3. nasal secretion: nasal cavity is without secretions 0 point; Mucus tears, few 2 points of amount; Mucus tears, many 4 points of amount; 6 points, pus tears.4. without dry pharynx, pharyngalgia 0 point; There is dry pharynx, pharyngalgia 2 points.5. without headache, giddy 0 point; There are headache, giddy 2 points.6. bronchia mucosal is congested: bronchia mucosal is without obviously congested 0 point; Bronchia mucosal pinkiness 2 points; Bronchia mucosal is kermesinus 4 points.7. concha nasalis inferior: concha nasalis inferior is without obvious edema 0 point; Concha nasalis inferior edema, smooth surface, softness, flexible 4 points.

Therapeutic Method:

Treatment group (of the present invention group) takes granule prepared by embodiment 1, and an oral 10mg, three times on the one seven days is a course for the treatment of.

Matched group oral azithromycin, 0.25g/ sheet, each 1,2 times on the one seven days is a course for the treatment of.Two groups of courses for the treatment of are 4.

Efficacy assessment standard:

1. comprehensive therapeutic effect criterion: according to integrated integral score value quantization assessment.

Cure: symptom and sign integrated value reduces more than >=90%.

Effective: symptom and sign make moderate progress, integrated value reduces >=30 ~ 89%.

Invalid: symptom and sign are not improved or increase the weight of, integrated value reduces less than 30%.

2. main symptom curative effect determinate standard: according to main symptom integration score value quantization assessment.

Cure: integration is down to 0.

Effective: integration reduces one or two grade (such as 6 → 2,6 → 4,4 → 2).

Invalid: integration does not reduce or increases.

Efficacy result:

Table 1 liang group patient effective percentage relative analysis

Group	Number of cases	Cure	Effectively	Invalid	Effectively total
						Treatment group	90	64(71.1％)	23(25.6％)	3(3.3％)	87(96.7％)
Matched group	90	27(30％)	15(16.7％)	48(53.3％)	42(46.7％)

Pay a return visit after 6 months, the situation for the treatment of group is stablized, the patient of not recurrence, matched group recurrent cases 7 example.

Result shows, Chinese medicine composition of the present invention is in treatment chronic simple rhinitis, evident in efficacy, not easily recurs, clinic extensive use and popularization.

Model case:

Case 1

Zhao, female, 51 years old is Qingdao City Laoshan District people, goes to a doctor on March 16th, 2014.Patient has a stuffy nose rhinorrhea more than 2 years, the yellow pus tears of stream and blow back into pharynx of having a stuffy nose over 2 years, time light time heavy, flu postemphasis.Treasure is chronic simple rhinitis.The capsule giving the embodiment of the present invention 3 is treated, twice daily, each two, 10 days courses for the treatment of, after the course for the treatment of, pus tears greatly reduce, and ventilation improves, headache, uncomfortable in chest, breathe hard, alleviate, look into nasal mucosa mild hyperaemia, two Carapax et Plastrum Testudinis is bigger, and two middle first is large, Shuan Zhong road, olfactory cleft and inferior nasal meatus rear end pus tears are a small amount of, after 3 courses for the treatment of of continual cure, look into two Carapax et Plastrum Testudinis, middle first is little, middle nasal meatus, olfactory cleft pneumonedema, nasal cavity is clean, and sick announcement is fully recovered.

Case 2

Money, female, 55 years old, Qingdao Jimo people, went to a doctor on May 1st, 2014.Patient main suit: heavy time light during nasal obstruction, watery nasal discharge half a year.Leave Rhinitis Symptoms after patient assessment once catches a cold the first half, meet cold increasing the weight of, olfactory sensation is slightly gone down, time sense dizzy headache, companion's cough thin sputum, inappetence, fatigue and asthenia, half congealed during stool, pale tongue with white fur, moderate pulse is weak.Check: nasal membrane swelling color is light, Mild edema.Western medicine diagnose: chronic rhinitis; Tcm diagnosis: chronic simple rhinitis.The medicine decoction giving the embodiment of the present invention 5 is treated, and twice daily, 10 days courses for the treatment of, after 2 courses for the treatment of, symptom disappears completely, nasal cavity inspection, and nasal membrane swelling disappears, and follows up a case by regular visits to and does not recur half a year.

Case 3

Grandson, female, 49 years old, people from Shinan District, Qingdao City, went to a doctor on November 23rd, 2013.Patient's readme suffers from chronic simple rhinitis for many years, often has both sides nasal obstruction, time light time heavy, with a small amount of nasal mucus, have a bad nose quick, adopt western medicine always, DeGrain.The powder giving the embodiment of the present invention 2 is treated, twice daily, and each two bags, 10 days courses for the treatment of, after 2 courses for the treatment of, symptom is controlled, and rear continuation takes 3 courses for the treatment of, and every Rhinitis Symptoms disappears, continue to take the dose of 2 courses for the treatment of to be consolidated, with examining, not having so far and recurring again.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (10)

1. treat a pharmaceutical composition for chronic simple rhinitis, it is characterized in that: the crude drug of described pharmaceutical composition is made up of Ramulus Cinnamomi, the Radix Angelicae Dahuricae, Fructus Forsythiae, Herba Taraxaci, Flos Magnoliae, Rhizoma Chuanxiong, Spica Prunellae, the Radix Astragali, Fructus Aurantii, Rhizoma Polygoni Cuspidati, Periostracum Cicadae, Placenta Hominis, Radix Salviae Miltiorrhizae, Fructus Amomi Rotundus, Fructus Liquidambaris, Radix Et Caulis Acanthopanacis Senticosi, Herba Leonuri, Herba Asari, Flos Carthami, Herba Houttuyniae, Folium Ginkgo, Radix Gentianae Macrophyllae, Herba Pogostemonis, Fructus Lycii, Semen Plantaginis, Herba Agrimoniae, Poria, Endothelium Corneum Gigeriae Galli, Radix Paeoniae Rubra, Rhizoma Acori Graminei, Radix Glycyrrhizae.

2. the pharmaceutical composition for the treatment of chronic simple rhinitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 12-20 part, Radix Angelicae Dahuricae 10-16 part, Herba Houttuyniae 3-8 part, Fructus Forsythiae 5-12 part, Flos Magnoliae 12-17 part, Herba Taraxaci 7-12 part, Flos Carthami 4-9 part, Radix Astragali 15-20 part, Fructus Aurantii 10-15 part, Rhizoma Polygoni Cuspidati 8-12 part, Placenta Hominis 2-5 part, Spica Prunellae 3-7 part, Radix Salviae Miltiorrhizae 11-14 part, Fructus Amomi Rotundus 9-15 part, Rhizoma Chuanxiong 3-6 part, Fructus Liquidambaris 8-13 part, Herba Leonuri 3-5 part, Herba Asari 1-3 part, Folium Ginkgo 5-10 part, Herba Pogostemonis 5-10 part, Radix Gentianae Macrophyllae 13-16 part, Fructus Lycii 3-10 part, Semen Plantaginis 8-13 part, Herba Agrimoniae 3-5 part, Radix Et Caulis Acanthopanacis Senticosi 1-3 part, Periostracum Cicadae 5-10 part, Poria 3-6 part, Endothelium Corneum Gigeriae Galli 8-13 part, Radix Paeoniae Rubra 3-5 part, Rhizoma Acori Graminei 11-16 part, Radix Glycyrrhizae 8-12 part.

3. the pharmaceutical composition for the treatment of chronic simple rhinitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 12 parts, the Radix Angelicae Dahuricae 16 parts, Herba Houttuyniae 3 parts, Fructus Forsythiae 12 parts, Flos Magnoliae 12 parts, Herba Taraxaci 10 parts, 9 parts, Flos Carthami, the Radix Astragali 15 parts, Fructus Aurantii 15 parts, Rhizoma Polygoni Cuspidati 8 parts, Placenta Hominis 5 parts, Spica Prunellae 3 parts, Radix Salviae Miltiorrhizae 14 parts, 9 parts, Fructus Amomi Rotundus, Rhizoma Chuanxiong 6 parts, Fructus Liquidambaris 8 parts, Herba Leonuri 5 parts, Herba Asari 1 part, Folium Ginkgo 10 parts, Herba Pogostemonis 5 parts, Radix Gentianae Macrophyllae 16 parts, Fructus Lycii 10 parts, Semen Plantaginis 8 parts, Herba Agrimoniae 5 parts, Radix Et Caulis Acanthopanacis Senticosi 1 part, Periostracum Cicadae 10 parts, 6 parts, Poria, Endothelium Corneum Gigeriae Galli 8 parts, Radix Paeoniae Rubra 3 parts, Rhizoma Acori Graminei 11 parts, 10 parts, Radix Glycyrrhizae.

4. the pharmaceutical composition for the treatment of chronic simple rhinitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 20 parts, the Radix Angelicae Dahuricae 10 parts, Herba Houttuyniae 8 parts, Fructus Forsythiae 5 parts, Flos Magnoliae 17 parts, Herba Taraxaci 12 parts, 4 parts, Flos Carthami, the Radix Astragali 20 parts, Fructus Aurantii 10 parts, Rhizoma Polygoni Cuspidati 12 parts, Placenta Hominis 2 parts, Spica Prunellae 7 parts, Radix Salviae Miltiorrhizae 11 parts, 15 parts, Fructus Amomi Rotundus, Rhizoma Chuanxiong 3 parts, Fructus Liquidambaris 13 parts, Herba Leonuri 3 parts, Herba Asari 3 parts, Folium Ginkgo 5 parts, Herba Pogostemonis 10 parts, Radix Gentianae Macrophyllae 13 parts, Fructus Lycii 3 parts, Semen Plantaginis 13 parts, Herba Agrimoniae 3 parts, Radix Et Caulis Acanthopanacis Senticosi 3 parts, Periostracum Cicadae 5 parts, 4 parts, Poria, Endothelium Corneum Gigeriae Galli 10 parts, Radix Paeoniae Rubra 4 parts, Rhizoma Acori Graminei 16 parts, 12 parts, Radix Glycyrrhizae.

5. the pharmaceutical composition for the treatment of chronic simple rhinitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 13 parts, the Radix Angelicae Dahuricae 11 parts, Herba Houttuyniae 4 parts, Fructus Forsythiae 6 parts, Flos Magnoliae 13 parts, Herba Taraxaci 7 parts, 5 parts, Flos Carthami, the Radix Astragali 18 parts, Fructus Aurantii 11 parts, Rhizoma Polygoni Cuspidati 9 parts, Placenta Hominis 4 parts, Spica Prunellae 6 parts, Radix Salviae Miltiorrhizae 12 parts, 13 parts, Fructus Amomi Rotundus, Rhizoma Chuanxiong 4 parts, Fructus Liquidambaris 9 parts, Herba Leonuri 4 parts, Herba Asari 2 parts, Folium Ginkgo 6 parts, Herba Pogostemonis 6 parts, Radix Gentianae Macrophyllae 14 parts, Fructus Lycii 5 parts, Semen Plantaginis 10 parts, Herba Agrimoniae 4 parts, Radix Et Caulis Acanthopanacis Senticosi 2 parts, Periostracum Cicadae 6 parts, 5 parts, Poria, Endothelium Corneum Gigeriae Galli 12 parts, Radix Paeoniae Rubra 3 parts, Rhizoma Acori Graminei 12 parts, 8 parts, Radix Glycyrrhizae.

6. the pharmaceutical composition for the treatment of chronic simple rhinitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 17 parts, the Radix Angelicae Dahuricae 15 parts, Herba Houttuyniae 7 parts, Fructus Forsythiae 11 parts, Flos Magnoliae 16 parts, Herba Taraxaci 8 parts, 8 parts, Flos Carthami, the Radix Astragali 16 parts, Fructus Aurantii 14 parts, Rhizoma Polygoni Cuspidati 11 parts, Placenta Hominis 3 parts, Spica Prunellae 5 parts, Radix Salviae Miltiorrhizae 13 parts, 14 parts, Fructus Amomi Rotundus, Rhizoma Chuanxiong 5 parts, Fructus Liquidambaris 12 parts, Herba Leonuri 3 parts, Herba Asari 1 part, Folium Ginkgo 10 parts, Herba Pogostemonis 9 parts, Radix Gentianae Macrophyllae 13 parts, Fructus Lycii 7 parts, Semen Plantaginis 11 parts, Herba Agrimoniae 3 parts, Radix Et Caulis Acanthopanacis Senticosi 1 part, Periostracum Cicadae 10 parts, 4 parts, Poria, Endothelium Corneum Gigeriae Galli 11 parts, Radix Paeoniae Rubra 4 parts, Rhizoma Acori Graminei 15 parts, 9 parts, Radix Glycyrrhizae.

7. the pharmaceutical composition for the treatment of chronic simple rhinitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 15 parts, the Radix Angelicae Dahuricae 12 parts, Herba Houttuyniae 5 parts, Fructus Forsythiae 9 parts, Flos Magnoliae 15 parts, Herba Taraxaci 9 parts, 7 parts, Flos Carthami, the Radix Astragali 19 parts, Fructus Aurantii 13 parts, Rhizoma Polygoni Cuspidati 10 parts, Placenta Hominis 4 parts, Spica Prunellae 4 parts, Radix Salviae Miltiorrhizae 11 parts, 11 parts, Fructus Amomi Rotundus, Rhizoma Chuanxiong 5 parts, Fructus Liquidambaris 10 parts, Herba Leonuri 5 parts, Herba Asari 3 parts, Folium Ginkgo 8 parts, Herba Pogostemonis 8 parts, Radix Gentianae Macrophyllae 14 parts, Fructus Lycii 9 parts, Semen Plantaginis 12 parts, Herba Agrimoniae 5 parts, Radix Et Caulis Acanthopanacis Senticosi 3 parts, Periostracum Cicadae 8 parts, 6 parts, Poria, Endothelium Corneum Gigeriae Galli 9 parts, Radix Paeoniae Rubra 5 parts, Rhizoma Acori Graminei 14 parts, Radix Glycyrrhizae 8-12 part.

8. the pharmaceutical composition for the treatment of chronic simple rhinitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Ramulus Cinnamomi 19 parts, the Radix Angelicae Dahuricae 14 parts, Herba Houttuyniae 6 parts, Fructus Forsythiae 7 parts, Flos Magnoliae 14 parts, Herba Taraxaci 9 parts, 6 parts, Flos Carthami, the Radix Astragali 17 parts, Fructus Aurantii 13 parts, Rhizoma Polygoni Cuspidati 10 parts, Placenta Hominis 4 parts, Spica Prunellae 4 parts, Radix Salviae Miltiorrhizae 11 parts, 11 parts, Fructus Amomi Rotundus, Rhizoma Chuanxiong 5 parts, Fructus Liquidambaris 10 parts, Herba Leonuri 5 parts, Herba Asari 3 parts, Folium Ginkgo 8 parts, Herba Pogostemonis 8 parts, Radix Gentianae Macrophyllae 14 parts, Fructus Lycii 4 parts, Semen Plantaginis 9 parts, Herba Agrimoniae 5 parts, Radix Et Caulis Acanthopanacis Senticosi 3 parts, Periostracum Cicadae 8 parts, 3 parts, Poria, Endothelium Corneum Gigeriae Galli 8 parts, Radix Paeoniae Rubra 5 parts, Rhizoma Acori Graminei 13 parts, 11 parts, Radix Glycyrrhizae.

9., according to the pharmaceutical composition of the arbitrary described treatment chronic simple rhinitis of claim 3-8, it is characterized in that: described pharmaceutical composition is prepared according to following method:

(1) each medical material of components by weight percent in the arbitrary described pharmaceutical composition of claim 3-8 is got, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decoct 1-2 hour: second time adds the water of 8-12 times amount, decoct 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) pulverized by dry extract obtained for step (2), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (2) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (2) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (2) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

10. the application of pharmaceutical composition in treatment chronic simple rhinitis medicine of the treatment chronic simple rhinitis as described in as arbitrary in claim 1-9.