CN104127578A - Traditional Chinese medicine composition for treating acute or chronic rhinitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating acute or chronic rhinitis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating acute or chronic rhinitis and a preparation method thereof. According to the technical scheme, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 6-10 parts of flower bud of lily magnolia, 3-5 parts of asarum, 10-50 parts of fructus forsythia, 10-20 parts of astragalus membranaceus, 9-15 parts of ligusticum wallichii, 5-15 parts of radix angelicae, 3-5 parts of dandelion, 20-40 parts of Chinese parsnip root, 10-30 parts of sanguisorba officinalis, 1-10 parts of poria cocos, 5-15 parts of medlar and 10-15 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention can be prepared into different clinical dosage forms, and has a good effect in treatment or prevention of the acute or chronic rhinitis.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of acute and chronic rhinitis and preparation method thereof.
Background technology
Rhinitis refers to the inflammation of nasal membrane and submucous tissue.Show as hyperemia or edema, patient often there will be nasal obstruction, stream clear water tears, rhinocnesmus, throat's discomfort, the symptoms such as cough.The wash sample material of nasal cavity secretion is called nasal mucus or nasal secretion, and its effect is to help dust out, and antibacterial is to keep the health of pulmonary.Under normal circumstances, after the nasal mucus of mixed cell and dust, be drawn to throat and finally enter gastric, little because of its secretory volume, generally can not attract much attention.In the time that inflammation appears in intranasal, nasal cavity can be secreted a large amount of nasal mucus, and can, because of infection yellowing, while flowing through throat, can cause cough, when nasal mucus amount is very many, can also flow out through prenaris.
Acute and chronic rhinitis is China's commonly encountered diseases and frequently-occurring disease, and according to the literature, various places cacorhinia incidence rate fluctuates between 10.7-44.5%, especially in southern various places, have a humid climate, sickness rate is very high, and wherein 76% is to occur in below 30 years old, from between 40-50 year, have 6.4%, within 50 years old, only have 1% or 2%, this disease course of disease is long, easily repeatedly later, Chang Yin, with symptoms such as headache, dizziness, hypomnesis, brings adverse effect to patient.
The sickness rate of rhinitis is and obviously increases trend, and its sickness rate is 10～20% according to statistics, and the sickness rate of rhinitis is especially with annual 3～5% speed increment in recent years.Medical circle analysis and research result shows: the upgrading of environmental pollution and the decline of air quality are the immediate causes that causes rhinitis sickness rate to increase.Be suspended in the toxic gas such as motor vehicle exhaust emission thing in the environment that we depend on for existence, incineration of garbage thing, industrial production waste gas thing, and each bacterioid, dust etc., all the time all entering in nasal cavity with people's breathing, once have an opportunity, these nuisances will be assembled and grow at nasal cavity, cause inflammation.People must breathe, and one breathes, and virus, antibacterial, anaphylactogen will enter with breathing, under the safeguard procedures protection without any corresponding, must cause rhinitis, even can repeatedly show effect.
The Therapeutic Method of rhinitis has naturopathy, Drug therapy, operative treatment etc., adopts simple physics or Drug therapy, DeGrain, and treatment cycle is long, easily recurrence; And employing operative treatment, its expense is high, has the risk that produces postoperative sequela.Chinese medicine rhinitis curative effect is reliable, and toxic and side effects is little, has broad prospects.
Summary of the invention
In order to overcome prior art deficiency, the invention provides a kind of Chinese medicine composition for the treatment of acute and chronic rhinitis, this Chinese medicine composition good effect, side effect is little, and it is made by the raw material of following weight portion: Flos Magnoliae 6-10 part, Herba Asari 3-5 part, Fructus Forsythiae 10-50 part, Radix Astragali 10-20 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, Herba Taraxaci 3-5 part, Radix Saposhnikoviae 20-40 part, Radix Sanguisorbae 10-30 part, Poria 1-10 part, Fructus Lycii 5-15 part, Radix Glycyrrhizae 10-15 part.
In Chinese medicine composition of the present invention, described Flos Magnoliae, nature and flavor: warm in nature, acrid in the mouth.Function cures mainly: dispersing wind and cold, clearing the nasal passage.For headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge.
Herba Asari, meridian distribution of property and flavor, pungent, temperature.Return lung, kidney channel; Function, dispels the wind, dispersing cold for relieving pain, warming the lung to resolve fluid-retention, a surname's clearing the nasal passage; Cure mainly, anemofrigid cold, nasal obstruction headache, anemofrigid-damp arthralgia, QI rising in reverse order abundant expectoration is breathed with cough and is had a toothache.
Fructus Forsythiae, nature and flavor hardship, is slightly cold.Gui Jing returns lung, the heart, small intestine meridian.Function cures mainly, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, pyretic stranguria urine retention.
The Radix Astragali, sweet, temperature.Return lung, spleen channel.Function cures mainly, invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, the up top, mountain peak that reaches; Enter again blood system, the descending sea of blood that reaches.Blood circulation promoting and blood stasis dispelling effect is extensive, the various diseases of suitable stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is the gas medicine in blood that former times people calls Rhizoma Chuanxiong, nearly says the functions such as pungent loose, the resolving depression of its residence, sensible, pain relieving.The pungent temperature rise of this product is loose, and all hyperactivity of YANG due to deficiency of YIN and excessive rising of liver-YANG person should not apply; Menorrhagia, anemia of pregnant woman also avoid use.
The Radix Angelicae Dahuricae, warm in nature, acrid in the mouth is micro-sweet, has expelling wind and removing dampness; Logical surreptitiously pain relieving; Effect of detumescence and apocenosis.Main headache due to common cold; Supraorbital bone pain; Toothache; Nasal obstruction; Nasal sinusitis; Domination of damp pathogen chronic diarrhea; Women leucorrhea; Ulcer sores; Venom.Clinical in headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.Also can be used for the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Rhizoma Atractylodis have drying damp and strengthening spleen, expelling wind and cold, and effect of improving eyesight, for dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.Control dampness taste, and see the thick disease such as turbid of distension and fullness in the abdomen, inappetence, fatigue and weakness, white and greasy fur, the compatibilities such as normal and Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae are applied.
Herba Taraxaci, nature and flavor with return through: bitter, sweet, cold.Return liver, stomach warp.Function with cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Radix Saposhnikoviae, acrid, sweet, warm.Return bladder, liver, spleen channel.Function cures mainly, inducing diaphoresis to dispel wind, and victory is wet, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Radix Sanguisorbae, bitter, acid, puckery, is slightly cold.Function cures mainly, cooling blood for hemostasis, removing toxic substances sore.Be used for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Poria, is commonly called as Poria, Song Ling, Poria, and for colonizing in the fungi plant on pinaster root, shape is as Rhizoma Dioscoreae esculentae, crust pitchy, the inside white or pink.Ancients claim that Poria is " god medicine " at 4 o'clock, because its effect is very extensive, regardless of the four seasons, by it and various compatibility of drugs, no matter cold, temperature, wind, all diseases that wets can be brought into play its unique effects.Poria sweet in the mouth, light, property are flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.
Fructus Lycii (formal name used at school: Lycium chinense) is the multi-branched shrub plant of Solanaceae Lycium, and high 0.5-1 rice, can reach more than 2 meters when cultivation.All there is distribution both at home and abroad.Fructus Lycii whole body is precious, and bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is recorded: " spring is adopted Folium Lycii, name day essence grass; Summer picks flowers, name Sempervivum tectorum; Qiu Caizi, name Fructus Lycii; Dong Caigen, name Cortex Lycii ".Fructus Lycii tender leaf also claims Fructus Lycii head, edible or make Fructus Lycii tea.Modern study, Fructus Lycii has the blood glucose of reduction, lipotropy, and can antiatherogenic effect.
Radix Glycyrrhizae, nature and flavor are sweet, flat.Gui Jing enters spleen, stomach, lung meridian.Function cures mainly: and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Process use, control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, infantile convulsion; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, and ulcer sores, separates poison of drug and alimentary toxicosis.
Chinese medicine composition of the present invention on Chinese medicinal components is selected with clearing away damp-heat, clearing the nasal passage, dispersing liver-energy, strengthening the spleen and stomach is main standard, simultaneously after Chinese medicine composition combination of the present invention, has significant anti-inflammatory activity effect.The present invention has carried out preferably the parts by weight of above-mentioned all taste Chinese medicine, and preferred condition is the enhancing of medicine to acute and chronic rhinitis therapeutic effect after drug matching is used.As a preferred embodiment of the present invention, Chinese medicine composition of the present invention is made by the raw material of following weight portion: 8 parts of Flos Magnoliaes, 4 parts of Herba Asaris, 30 parts of Fructus Forsythiaes, 15 parts of the Radixs Astragali, 12 parts of Rhizoma Chuanxiongs, 9 parts of the Radixs Angelicae Dahuricae, 4 parts of Herba Taraxacis, 30 parts of Radix Saposhnikoviaes, 20 parts of Radix Sanguisorbaes, 6 parts, Poria, 9 parts of Fructus Lyciis, 12 parts, Radix Glycyrrhizae.
In order to express better Chinese medicine composition of the present invention, Chinese medicine composition of the present invention can be prepared into conventional clinically dosage form.It mainly comprises following step: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1-2 hour, and merge extractive liquid,, filters filtrate recycling ethanol, concentrating under reduced pressure; 5-10 times of water gaging of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight decocts secondary, decocts for the first time 2-3 hour, decocts for the second time 1-2 hour, collecting decoction, filter, filtrate decompression is concentrated, adds ethanol,-5～-2 DEG C of cold preservation 12-48 hour, filter filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mix, dry, pulverize into fine powder, mix, sieve, prepare conventional Chinese medicine pharmaceutical dosage form clinically.
Any such as in the middle of, pill, tablet, granule, oral liquid, capsule, unguentum, Emulsion, masticatory, injection of conventional Chinese medicine pharmaceutical dosage form clinically.Preferably, Chinese medicine composition of the present invention is prepared into granule, tablet or capsule according to conventional preparation technology.
In described pharmaceutical dosage form, add drug excipient.Preferably, described excipient is one or more in the middle of flavoring agent, dispersant, binding agent, thickening agent, lubricant, diluent.
The present invention also asks to protect the purposes of above-mentioned Chinese medicine composition in preparation treatment acute and chronic rhinitis medicine.Pharmaceutical composition of the present invention, in the time for the treatment of acute and chronic rhinitis, demonstrates significant anti-inflammatory activity.Drug effect embodiment 8 of the present invention shows, the heavy dose of group of the present invention cause scorching after 2,3,4 and 5 hours points have obvious inhibitory action (P<0.01), middle dosage group cause scorching after 2 hours points have obvious inhibitory action (P<0.01), middle dosage group has inhibitory action (P<0.05) at 3,4 hours points, and its reduction effect to swelling exists significant dose-effect relationship.Under same experiment condition, positive control drug cause scorching after 2,3,4 and 5 hours points have obvious inhibitory action (P<0.01), but effect is not as good as the heavy dose of group of the present invention.
The present invention is inventor through research repeatedly, progressively improves, and last successful a kind of curative effect is treated the medicine of acute and chronic rhinitis preferably, can verify the therapeutic effect of medicine of the present invention to acute and chronic rhinitis by 700 routine clinical cases.Wherein, clinical cure: symptom all disappears, not recurrence above in continuous 1 year; Effective: symptom all disappears, recurrence in 1 year, but symptom obviously alleviates; Effective: symptom is clearly better, recurrence again in half a year; Invalid: symptom is not improved or drug withdrawal recurs.
The chronic rhinitis patient that the present invention takes this medicine to 500 examples has carried out clinical observation, has obtained good curative effect, in 500 routine patients, after medication March, cures 425 examples, and cure rate accounts for 85%; 40 examples that take a turn for the better, obvious effective rate accounts for 8%; Effective 26 examples, effective percentage accounts for 5.2%; Total effective rate 98.2%, no effect 9, inefficiency accounts for 1.8%.
The acute rhinitis patient that the present invention takes this medicine to 200 examples has carried out clinical observation, has obtained equally good curative effect, and in 200 routine patients, medication, after 4 days, is cured 160 examples, and cure rate accounts for 80%; 12 examples that take a turn for the better, obvious effective rate accounts for 6%; Effective 10 examples, effective percentage accounts for 5%; Total effective rate 91%, invalid 18 examples, inefficiency accounts for 9%.
Detailed description of the invention
Further describe the present invention by specific embodiment below, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, change, combination or replacement that the present invention is carried out, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: 8 parts of Flos Magnoliaes, 4 parts of Herba Asaris, 30 parts of Fructus Forsythiaes, 15 parts of the Radixs Astragali, 12 parts of Rhizoma Chuanxiongs, 9 parts of the Radixs Angelicae Dahuricae, 4 parts of Herba Taraxacis, 30 parts of Radix Saposhnikoviaes, 20 parts of Radix Sanguisorbaes, 6 parts, Poria, 9 parts of Fructus Lyciis, 12 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1.5 hours, merge extractive liquid,, filtered filtrate recycling ethanol, concentrating under reduced pressure; 8 times of water gagings of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight decoct secondary, decoct for the first time 2.5 hours, decoct for the second time collecting decoction 1.5 hours, filter, filtrate decompression is concentrated, adds ethanol,-3 DEG C of cold preservation 24 hours, filters filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mix, dry, pulverize into fine powder, mix, sieve, make tablet by conventional formulation method.
Embodiment 2
Prescription: 8 parts of Flos Magnoliaes, 4 parts of Herba Asaris, 30 parts of Fructus Forsythiaes, 15 parts of the Radixs Astragali, 12 parts of Rhizoma Chuanxiongs, 9 parts of the Radixs Angelicae Dahuricae, 4 parts of Herba Taraxacis, 30 parts of Radix Saposhnikoviaes, 20 parts of Radix Sanguisorbaes, 6 parts, Poria, 9 parts of Fructus Lyciis, 12 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1.5 hours, merge extractive liquid,, filtered filtrate recycling ethanol, concentrating under reduced pressure; 8 times of water gagings of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight decoct secondary, decoct for the first time 2.5 hours, decoct for the second time collecting decoction 1.5 hours, filter, filtrate decompression is concentrated, adds ethanol,-3 DEG C of cold preservation 24 hours, filters filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mix, dry, pulverize into fine powder, mix, sieve, make capsule by conventional formulation method.
Embodiment 3
Prescription: 6 parts of Flos Magnoliaes, 3 parts of Herba Asaris, 10 parts of Fructus Forsythiaes, 10 parts of the Radixs Astragali, 9 parts of Rhizoma Chuanxiongs, 5 parts of the Radixs Angelicae Dahuricae, 3 parts of Herba Taraxacis, 20 parts of Radix Saposhnikoviaes, 10 parts of Radix Sanguisorbaes, 1 part, Poria, 5 parts of Fructus Lyciis, 10 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 2 hours, merge extractive liquid,, filtered filtrate recycling ethanol, concentrating under reduced pressure; 10 times of water gagings of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight decoct secondary, decoct for the first time 3 hours, decoct for the second time collecting decoction 2 hours, filter, filtrate decompression is concentrated, adds ethanol,-5 DEG C of cold preservation 48 hours, filters filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mix, dry, pulverize into fine powder, mix, sieve, make capsule by conventional formulation method.
Embodiment 4
Prescription: 10 parts of Flos Magnoliaes, 5 parts of Herba Asaris, 50 parts of Fructus Forsythiaes, 20 parts of the Radixs Astragali, 15 parts of Rhizoma Chuanxiongs, 15 parts of the Radixs Angelicae Dahuricae, 5 parts of Herba Taraxacis, 40 parts of Radix Saposhnikoviaes, 30 parts of Radix Sanguisorbaes, 10 parts, Poria, 15 parts of Fructus Lyciis, 15 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1 hour, merge extractive liquid,, filtered filtrate recycling ethanol, concentrating under reduced pressure; 5 times of water gagings of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight decoct secondary, decoct for the first time 2 hours, decoct for the second time collecting decoction 1 hour, filter, filtrate decompression is concentrated, adds ethanol,-2 DEG C of cold preservation 12 hours, filters filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mix, dry, pulverize into fine powder, mix, sieve, make capsule by conventional formulation method.
Embodiment 5
Prescription: 6 parts of Flos Magnoliaes, 5 parts of Herba Asaris, 10 parts of Fructus Forsythiaes, 20 parts of the Radixs Astragali, 9 parts of Rhizoma Chuanxiongs, 15 parts of the Radixs Angelicae Dahuricae, 3 parts of Herba Taraxacis, 40 parts of Radix Saposhnikoviaes, 10 parts of Radix Sanguisorbaes, 10 parts, Poria, 5 parts of Fructus Lyciis, 15 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 2 hours, merge extractive liquid,, filtered filtrate recycling ethanol, concentrating under reduced pressure; 10 times of water gagings of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight decoct secondary, decoct for the first time 2 hours, decoct for the second time collecting decoction 1 hour, filter, filtrate decompression is concentrated, adds ethanol,-5 DEG C of cold preservation 12 hours, filters filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mix, dry, pulverize into fine powder, mix, sieve, make capsule by conventional formulation method.
Embodiment 6
Prescription: 10 parts of Flos Magnoliaes, 3 parts of Herba Asaris, 50 parts of Fructus Forsythiaes, 10 parts of the Radixs Astragali, 15 parts of Rhizoma Chuanxiongs, 5 parts of the Radixs Angelicae Dahuricae, 5 parts of Herba Taraxacis, 20 parts of Radix Saposhnikoviaes, 30 parts of Radix Sanguisorbaes, 1 part, Poria, 15 parts of Fructus Lyciis, 10 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1 hour, merge extractive liquid,, filtered filtrate recycling ethanol, concentrating under reduced pressure; 5 times of water gagings of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight decoct secondary, decoct for the first time 3 hours, decoct for the second time collecting decoction 2 hours, filter, filtrate decompression is concentrated, adds ethanol,-2 DEG C of cold preservation 48 hours, filters filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mix, dry, pulverize into fine powder, mix, sieve, make capsule by conventional formulation method.
Embodiment 7
Prescription: 8 parts of Flos Magnoliaes, 4 parts of Herba Asaris, 30 parts of Fructus Forsythiaes, 15 parts of the Radixs Astragali, 12 parts of Rhizoma Chuanxiongs, 9 parts of the Radixs Angelicae Dahuricae, 4 parts of Herba Taraxacis, 30 parts of Radix Saposhnikoviaes, 20 parts of Radix Sanguisorbaes, 6 parts, Poria, 9 parts of Fructus Lyciis, 12 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1.5 hours, merge extractive liquid,, filtered filtrate recycling ethanol, concentrating under reduced pressure; 8 times of water gagings of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight decoct secondary, decoct for the first time 2.5 hours, decoct for the second time collecting decoction 1.5 hours, filter, filtrate decompression is concentrated, adds ethanol,-3 DEG C of cold preservation 24 hours, filters filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mix, dry, pulverize into fine powder, mix, sieve, with the agent of conventional formulation method granulation.
Embodiment 8 Chinese medicine composition xylol of the present invention causes the impact of mice ear
Get 60 of healthy Wistar rats, body weight 170-180g, male and female half and half, be divided at random 5 groups, every group 12, be respectively heavy dose of group (3.2g/kg), middle dosage group (1.6g/kg), small dose group (0.8g/kg) prepared by the embodiment of the present invention 2, positive control Biyan Ning capsule group (0.35g/kg) (Quanzhou, Fujian Province Luo Shangshan pharmaceutical factory) and distilled water matched group.Every day gastric infusion once, for three days on end, the isopyknic distilled water of blank group gavage.After last administration 1 hour, the right back sufficient plantar subcutaneous injection 1% carrageenin 0.05ml of every Mus causes inflammation, cause scorching before and cause the sufficient sole of the foot volume (capillary tube measurement by magnification method) of measuring respectively fixed position after scorching for 1,2,3,4,5 hour, calculating causes the sufficient volume difference in scorching front and back as swelling, in table 1.
The impact (X ± SD, n=10) of rat toes swelling due to table 1 on Carrageenan
Note: with the comparison of distilled water matched group, * p<0.05, * * p<0.01.
Result shows, the heavy dose of group of the present invention cause scorching after 2,3,4 and 5 hours points have obvious inhibitory action (P<0.01), middle dosage group cause scorching after 2 hours points have obvious inhibitory action (P<0.01), middle dosage group has inhibitory action (P<0.05) at 3,4 hours points, and its reduction effect to swelling exists significant dose-effect relationship.Under same experiment condition, positive control drug cause scorching after 2,3,4 and 5 hours points have obvious inhibitory action (P<0.01), but effect is not as good as the heavy dose of group of the present invention.
Claims (6)
1. treat a Chinese medicine composition for acute and chronic rhinitis, it is characterized in that it is made by the raw material of following weight portion: Flos Magnoliae 6-10 part, Herba Asari 3-5 part, Fructus Forsythiae 10-50 part, Radix Astragali 10-20 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, Herba Taraxaci 3-5 part, Radix Saposhnikoviae 20-40 part, Radix Sanguisorbae 10-30 part, Poria 1-10 part, Fructus Lycii 5-15 part, Radix Glycyrrhizae 10-15 part.
2. Chinese medicine composition as claimed in claim 1, is characterized in that it is made by the raw material of following weight portion: 8 parts of Flos Magnoliaes, 4 parts of Herba Asaris, 30 parts of Fructus Forsythiaes, 15 parts of the Radixs Astragali, 12 parts of Rhizoma Chuanxiongs, 9 parts of the Radixs Angelicae Dahuricae, 4 parts of Herba Taraxacis, 30 parts of Radix Saposhnikoviaes, 20 parts of Radix Sanguisorbaes, 6 parts, Poria, 9 parts of Fructus Lyciis, 12 parts, Radix Glycyrrhizae.
3. a preparation method for Chinese medicine composition as claimed in claim 1, is characterized in that it comprises the following steps: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1-2 hour, and merge extractive liquid,, filters filtrate recycling ethanol, concentrating under reduced pressure; 5-10 times of water gaging of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight decocts secondary, decocts for the first time 2-3 hour, decocts for the second time 1-2 hour, collecting decoction, filter, filtrate decompression is concentrated, adds ethanol,-5～-2 DEG C of cold preservation 12-48 hour, filter filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mix, dry, pulverize into fine powder, mix, sieve, prepare conventional Chinese medicine pharmaceutical dosage form clinically.
4. according to the preparation method in claim 3, it is characterized in that, described pharmaceutical dosage form is any in the middle of pill, tablet, granule, oral liquid, capsule, unguentum, Emulsion, masticatory, injection.
5. according to the said preparation method of claim 4, it is characterized in that having added drug excipient in described pharmaceutical dosage form.
6. according to the said preparation method of claim 5, it is characterized in that described excipient is one or more in the middle of flavoring agent, dispersant, binding agent, thickening agent, lubricant, diluent.
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| CN102462784A (en) * | 2010-11-10 | 2012-05-23 | 罗朝雯 | Chinese herbal medicine prescription for treating rhinitis |
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