CN104606600A - Traditional Chinese medicine composition for treating interstitial lung disease and preparation method of composition - Google Patents

Traditional Chinese medicine composition for treating interstitial lung disease and preparation method of composition Download PDF

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CN104606600A
CN104606600A CN201510005464.6A CN201510005464A CN104606600A CN 104606600 A CN104606600 A CN 104606600A CN 201510005464 A CN201510005464 A CN 201510005464A CN 104606600 A CN104606600 A CN 104606600A
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lung disease
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纪铜镇
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纪铜镇
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Abstract

The invention discloses a traditional Chinese medicine composition for treating interstitial lung disease. The traditional Chinese medicine composition comprises the following components according to a certain weight ratio: bamboo leaves, raw gypsum, American ginseng, radix ophiopogonis, lily, dried rehamnnia root, prepared rehmannia root, fritillary bulb, radix scrophulariae, angelica sinensis, radix paeoniae alba, platycodon grandiflorum, rhizoma pinelliae, asparagus cochinchinensis, Chinese yam, radix stemonae, radix glehniae, frost mulberry leaves, chrysanthemum, schisandra chinensis, colla corii asini, cortex lycii radicis, astragalus membranaceus, rhizoma cimicifugae and radix bupleuri. The traditional Chinese medicine composition has the functions of clearing heat and promoting fluid production, boosting qi and nourishing yin, moistening lung and calming the nerves, replenishing and nourishing blood, and can be used for effectively treating interstitial lung disease.

Description

A kind of Chinese medicine composition for the treatment of interstitial lung disease and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of interstitial lung disease.The invention still further relates to the preparation method of this Chinese medicine composition.
Background technology
Interstitial lung disease (ILD) turns to pathology basic lesion with diffusivity pulmonary parenchyma, alveolar inflammation and interstitial fibers, reduce with activeness dyspnea, x-ray rabat diffuse infiltrating shade, restrictive ventilatory disorder, disperse (DLCO) function and hypoxemia be the variety classes disease group of clinical manifestation formed clinical-general name of pathology entity.Interstitial lung disease relates to alveolar epithelium, pulmonary capillary endothelium, basement membrane, blood vessel week and perilymphatic tissue.Sickness rate, prevalence rate and death increased along with the age.
Interstitial lung disease is not pernicious usually, neither caused by the known Infectious diseases source.Although this disease also exists acute stage, but onset is often hidden attacks, and disease is chronic process, and body shows as inflammatory reaction to its initial reaction in lung and alveolar wall, cause alveolitis, last inflammation, by spreading to contiguous stromal portion and blood vessel, finally produces interstitial fibrosis, causes cicatrix to produce and lung tissue destruction, ventilatory function is reduced, inflammation also can involve trachea, capillary bronchus, often accompanies organized pneumonia, is also the one performance of interstitial pneumonia.This group disease has many common features, comprises similar symptom, X line sign and pulmonary function test feature.Mucus thick sputum can be had during secondary infection, companion obviously becomes thin, the General Symptoms such as weak, anorexia, membra arthralgia, acute stage, can with heating.Interstitial lung disease length is with complication such as cardiovascular complications, pulmonary infection, pulmonary infarction, malignant disease, pneumothoraxs.
At present, treatment interstitial lung disease mainly relies on and has Western medicine, and adopt antibiotic or antiviral drug to treat, but drug side effect is large, dependency is strong, causes dose increasing, causes vicious cycle, cause the state of an illness to prolong silk floss and do not heal.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has evident in efficacy for treatment interstitial lung disease, cheap, has no side effect, the feature not easily recurred.
Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment interstitial lung disease.
Inventor is in clinical treatment practice for many years, observe the misery that interstitial lung disease brings to patient, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of interstitial lung disease repeatedly, the present invention selects Folium Bambusae, Gypsum Fibrosum, Radix Panacis Quinquefolii, Radix Ophiopogonis, Bulbus Lilii, Radix Rehmanniae, Radix Rehmanniae Preparata, Bulbus Fritillariae Thunbergii, Radix Scrophulariae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Platycodonis, the Rhizoma Pinelliae, Radix Asparagi, Rhizoma Dioscoreae, the Radix Stemonae, Radix Glehniae, Folium Mori, Flos Chrysanthemi, Fructus Schisandrae Chinensis, Colla Corii Asini, Cortex Lycii, the Radix Astragali, Rhizoma Cimicifugae, Radix Bupleuri combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is clearing away heat and promoting production of body fluid, boosting qi and nourishing yin, lung moistening is calmed the nerves, effect of blood-supplementing blood-nourishing, thus effectively can treat interstitial lung disease.
The effect of Chinese medicine of the present invention:
Wherein:
Folium Bambusae: be the dry stem and leaf of grass Herba Lophatheri Lophatherum gracile Brongn..Nature and flavor: sweet, light, cold.GUIXIN, stomach, small intestine meridian.Clearing heat and relieving fidgetness, diuresis.For calentura excessive thirst, hot urination drenches pain, aphtha of the mouth and tongue.Folium Bambusae is sweet trembles with fear into the heart, and can clear away heart-fire relieving restlessness, again can promoting the production of body fluid to quench thirst, and can the heresy of cool loose part of the body cavity above the diaphragm housing the heart and lungs wind heat, hinders, often join Gypsum Fibrosum, Radix Ophiopogonis, Radix Ginseng etc. for gas Tianjin two.
Gypsum Fibrosum: be Sulfates mineral anhydrite race Gypsum Fibrosum, main containing hydrous calcium sulfate (CaSO42H2O).Nature and flavor: sweet, pungent, Great Cold.Attach to the lung and stomach meridians.Effect: clearing away heat-fire, relieving restlessness is quenched the thirst.For fever caused by exogenous pathogenic factors, high hot excessive thirst, dyspnea and cough due to lung-heat, the high Sheng of stomach-fire, headache, toothache.For diseases such as epidemic febrile disease, the large heat of lung stomach, hyperpyrexia, thirsty, fidgety, full and large pulse.Gypsum Fibrosum property of medicine Great Cold, kind clearing heat in QI system divides excess-heat, therefore is applicable to the disease of lung sthenia gastropyrexia, for cough due to lung-heat, asthma.Pathogenic heat attack lung, the diseases such as body Fa Gaore, cough, flaring of nares out of breath, thirst with desire to drink, available Gypsum Fibrosum eliminating heat from the lung.
Radix Panacis Quinquefolii: be the dry root of Araliaceae Radix Panacis Quinquefolii Panax quinquefolium L..Nature and flavor: sweet, micro-hardship are cool.GUIXIN, lung, kidney channel.Effect: boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Lose for deficiency of vital energy the moon, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat." book on Chinese herbal medicine asks former ": lung qi this in kidney, the medicine of all lung benefiting gas, multi-band is slightly cold, but this then bitter cold, and only fire is contained and felt frustrated, and cough expectorant blood, impairment caused by overstrain consumption of essence person should it.
Radix Ophiopogonis: be the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..Nature and flavor: sweet, micro-hardship, to be slightly cold.GUIXIN, lung, stomach warp.Effect: reinforcing stomach reg fluid, nourishing lung-YIN, clear away heart-fire relieving restlessness.Radix Ophiopogonis can clear away heart-fire in yin nourishing, and relieving restlessness is calmed the nerves.The heart-nutriment, fever aggravated at night is entered with controlling warm febrile disease.
Bulbus Lilii: be the dry meat scale leaf of liliaceous plant tiger lily Lilium lancifolium Thunb., Bulbus Lilii Lilium brownii F.E.Brown var. viridulum Baker or Lilium tenuifolium Lilium pumilum DC..Nature and flavor: sweet, cold.GUIXIN, lung meridian.Effect: nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded." Bencao Jingshu ": Bulbus Lilii, main pathogen abdominal distention.So-called pathogen person, namely pathogenic heat also.
Radix Rehmanniae: be the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Nature and flavor: sweet, cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Can be used for Tianjin wound thirsty, interior-heat is quenched one's thirst.This product is sweet cold, can among heat clearing away YIN nourishing and the production of body fluid promoting, cold in nature and enter blood system, can not only the heat of clearing heat in YING system blood system and removing heat from blood, and sweet in the mouth is cold in nature can promote the production of body fluid, and has the effect of nourishing YIN and clearing away heat, is often equal to Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae) and uses.
Radix Rehmanniae Preparata: be scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa(Gdertn) Iibosch.ex Fisch. et Mey.) tuber form through Processing methods.Nature and flavor: sweet, tepor.Return liver, kidney channel.Effect: nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.Radix Rehmanniae Preparata can be enriched blood YIN nourishing and liver-nourishing kidney-boosting, and all blood deficiency the moon loses, dizzy caused by deficiency of the liver and kindey, all can apply.
Bulbus Fritillariae Thunbergii: be the dry bulb of liliaceous plant Bulbus Fritillariae Thunbergii Fritillaria thunbergii Miq..Nature and flavor: bitter, cold.Return lung, heart channel.Effect: heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing.For wind-heat invading the lung, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore." book on Chinese herbal medicine is just " is recorded: control greatly lung abscess lung and wither, cough with asthma, and spit blood, mental disorder, falls most in epistaxis, kind relieving stagnation, and relieve the pain pain, and relieving distension is full, clearing away liver-fire, improve visual and auditory acuity, except seasonal epidemic pathogens dysphoria with smothery sensation, and jaundice stranguria with urinary obstruction, hematuria of having blood in stool; Relieving heat toxin, kills parasites and treats sore throat, scrofula, acute mastitis carbuncle on the back, all carbuncle and ulcer toxic swellings.
Radix Scrophulariae: be the dry root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl..Nature and flavor are sweet, bitter, salty, are slightly cold.Return lung, stomach, kidney channel.Effect: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.There is slight hypoglycemic activity.To join the army for: warm febrile disease the card of blood, consumption of YIN caused by febrile disease.There is clearing away heat and cooling blood, effect of removing toxic substances YIN nourishing.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis has inhibitory action to central nervous system, and volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia.Carry according to " book on Chinese herbal medicine is just ": " its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, nothing unsuitable." modern medicine study confirmation, Radix Angelicae Sinensis has antibacterial, antiinflammation, and Radix Angelicae Sinensis hot water extract has obvious inhibitory action to during chronic articular rheumatism acute attack.
The Radix Paeoniae Alba: be the dry root of dicotyledon ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: cool, picric acid, is slightly cold.Effect: easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receives antiperspirant.Research shows: the paeoniflorin contained in the Radix Paeoniae Alba has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.
Radix Platycodonis: be the root of dicotyledon campanulaceae Campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A. DC..Nature and flavor are bitter, pungent, tepor.Enter lung meridian.Effect: lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.Radix Platycodonis is lung meridian edema caused by disorder of QI medicine, and pains are put down, and namely rises and falls, being good at a surname and opening lung qi, therefore exopathogen violates lung, cough with copious phlegm, and disease such as grade uncomfortable in chest of having a stuffy nose, no matter cold and heat all can adapted.
The Rhizoma Pinelliae: be the tuber at the Rhizoma Arisaematis section plant Rhizoma Pinelliae (Pinellia ternata (Thunb.) Breit.).Nature and flavor are pungent, temperature, poisonous.Enter spleen, stomach warp.Effect: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.The pungent loose warm-dryness syndrome of these product is poisonous, main enter taste double enter lung, water of manageing it wets, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.Water is wet to be gone, and the strong and sputum of spleen is from disappearing, and inverse gas falls then harmonization of the stomach and feeling of fullness vomiting from only, therefore is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.Both cure mainly the abundant expectoration cough with asthma QI rising in reverse order of spleen damp-phlegm heap soil or fertilizer over and around the roots, control again the dizzy palpitation and insomnia that damp-phlegm is violated." property of medicine opinion ": expectorant saliva, appetite promoting and the spleen strengthening, anti-nausea, go expectorant in the heart full, lower lung qi, master coughs knot.
Radix Asparagi: be the dried root of liliaceous plant Radix Asparagi Asparagus cochinchinensis (Lour.) Merr..Nature and flavor: sweet, bitter, cold.Return lung, kidney channel.Effect: nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.For dryness of the lung dry cough, pertussis expectorant sticks, dry throat and mouth, dryness of the intestine constipation.Radix Asparagi and Radix Ophiopogonis often use simultaneously, to strengthen nourishing lung-YIN, the effect of the relieving restlessness that clears away heart-fire.
Rhizoma Dioscoreae: be the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..Nature and flavor are put down, sweet.Return spleen, lung, kidney channel.Effect: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.
The Radix Stemonae: be the dried root of Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona japonica (Bl.) Miq. or radix stemonae tuberosae Stemona tuberosa Lour..Nature and flavor: sweet, bitter, tepor.Return lung meridian.Slightly poisonous.Effect: nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outer for head louse, body louse, enterobiasis, pudendal pruritus.Research shows that Radix stemonae japonicae infusion is in vitro to various pathogens, and some pathomycete has certain inhibitory action.
Radix Glehniae: be the dry root of samphire glehnia littoralis Glehnia littoralis Fr. Schmidt ex Miq..Nature and flavor: sweet, micro-hardship, to be slightly cold.Return lung, kidney channel.Effect: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.Thirsty for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound.Research display: Radix Glehniae not only has the effect of antipyretic-antalgic, can also strengthen body immunity.
Folium Mori: be the dried leaves of moraceae plants Mulberry Morus alba L..Nature and flavor: sweet, bitter, cold.Return lung, Liver Channel.Effect: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.Folium Mori are gently dispersed clearly, wind heat of faling apart, but effect is more weak.Clinical being mainly used in lets out clearly lung liver, as wind heat attacks lung, cough ant phlegm, or dryness-heat impairing the lung, dry cough without phlegm; Join Gypsum Fibrosum, Radix Ophiopogonis, cure mainly clearing away dryness lung moistening.
Flos Chrysanthemi: be the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..Nature and flavor: sweet, bitter, are slightly cold.Return lung, Liver Channel.Effect: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.Flos Chrysanthemi dispelling wind is more weak, and heat clearing away power is good, often joins the same use of Folium Mori, also can join Radix Scutellariae, Fructus Gardeniae controls the diseases such as intenseness of heat is fidgety for affection due to external wind and heat.Flos Chrysanthemi controls conjunctival congestion and swelling pain, no matter belongs to liver-fire or wind heat causer, all can apply.
Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or schisandra chinensis Schisandra sphenanthera Rehd. et Wils..Nature and flavor: warm, sour, sweet.Return lung, the heart, kidney channel.Function: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Colla Corii Asini: for the skin of equine species donkey Equus Asinus L. is through decocting, concentrating the solid gum made.Nature and flavor: sweet are flat.Return lung, liver, kidney channel.Effect: YIN nourishing of enriching blood, moisturizes, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy." detailed outline ": Colla Corii Asini, will just enrich blood and liquid greatly, therefore can lung heat clearing tonifying YIN and control all cards.By Chen Ziming cloud: tonify deficiency animal glue, remove wind Colla Corii Asini.Cheng Wuji cloud: deficiency of YIN person, tonifying with drugs of thick flavor, Colla Corii Asini sweet, with nourishing YIN blood.Yang Shiying cloud: all control to breathe heavily cough, no matter the deficiency of the lung, excess of the lung, can under can temperature, palpus Colla Corii Asini is to pacify lung lung moistening, and its property is peaceful, is lung meridian key medicine.
Cortex Lycii: be the dry root bark of matrimony vine of solanaceae plant Lycium chinense Mill. or lycium barbarum Lycium barbarum L..Nature and flavor: sweet, cold.Return lung, liver, kidney channel.Function cures mainly: removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.
The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.Effect: tonifying Qi and lifting yang, consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.This product all has inhibitory action to dysentery bacterium, anthrax bacillus, α-hemolytic streptococcus, beta hemolytic streptococcus, diphtheria corynebacterium, bacillus pseudodiphthericus, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, bacillus subtilis etc. in vitro.
Rhizoma Cimicifugae: be ranunculaceae plant C.heracleifolia Cimicifuga heracleifolia Kom., Cimicifuga Dahurica Cimicifuga dahurica (Turcz.) Maxim. or the dry rhizome of Rhizoma Cimicifugae Cimicifuga foetida L..Nature and flavor are pungent, micro-sweet, are slightly cold.Return lung, spleen, stomach, large intestine channel.Effect: deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.Antibacterial action: in vitro Rhizoma Cimicifugae can suppress the growth of tubercule bacillus. the water logging agent (1:4) of its mutation greenery Rhizoma Cimicifugae Cimicifuga foetida L. var. simplex Huth. all has inhibitory action in various degree to dermatophytess such as being permitted blue achorion, Du's big belly microspore tinea bacterium difficult to understand, rust microspore tinea bacterium, epidermophyton rubrum in vitro. and have report to point out, Rhizoma Cimicifugae has stronger inhibitory action to staphylococcus aureus, anthrax bacillus; Also inhibitory action is in various degree had to group B streptococcus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus, escherichia coli, dysentery bacterium.
Radix Bupleuri: be Umbelliferae herbaceos perennial Radix Bupleuri Bupleurum chinense DC.(Radix Bupleuri) or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd.(Radix Bupleuri Scorzonerifolii) root or herb.Nature and flavor: bitter, pungent, be slightly cold.Return liver, gallbladder meridian.Effect: reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang.Radix Bupleuri has the effect of obvious calmness, analgesia and anti-bacteria and anti-virus.
Side's solution of the present invention is: Folium Bambusae clearing heat and relieving fidgetness in side; Gypsum Fibrosum clearing away heat-fire, relieving restlessness quench the thirst, Radix Panacis Quinquefolii boosting qi and nourishing yin, clearing away heat and promoting production of body fluid, and Radix Ophiopogonis, Bulbus Lilii nourishing lung-YIN, clear away heart-fire relieving restlessness; Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Radix Rehmanniae Preparata nourishing YIN and supplementing blood, above seven tastes are monarch drug altogether, fundamentally carry out nourishing lung-YIN, clearing away heat and promoting production of body fluid from disease; the Lung protection of patient's pathological changes is got up; expulsion pathogenic heat, strengthen the resistivity of patient, thus fundamentally treat the disease of patient.Bulbus Fritillariae Thunbergii heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing, Radix Scrophulariae clearing away heat and cooling blood, YIN nourishing are detoxified, Chinese angelica blood supplementing is invigorated blood circulation, the Radix Paeoniae Alba enrich blood easing the affected liver, yin fluid astringing receive antiperspirant, Radix Platycodonis lung qi dispersing eliminates the phlegm, Rhizoma Pinelliae drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, Radix Asparagi nourishing YIN to relieve dryness, lung heat clearing are promoted the production of body fluid, Rhizoma Dioscoreae is promoted the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission, above eight tastes are ministerial drug altogether, not only can increase effect of monarch drug nourishing YIN and moistening the lung, clearing away heat and cooling blood, and can enrich blood invigorate blood circulation, yin fluid astringing receive antiperspirant, drying dampness to eliminate phlegm, other complication of interstitial lung disease can be treated, alleviate the discomfort of patient.Radix Stemonae nourishing the lung to arrest cough, Radix Glehniae nourishing YIN and clearing away lung-heat, Folium Mori dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, the heat clearing away of chrysanthemum powder forimproving wind, Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, Colla Corii Asini nourishing blood YIN nourishing, Cortex Lycii lung heat clearing pathogenic fire reducing, Radix Astragali tonifying Qi and lifting yang, Rhizoma Cimicifugae heat-clearing and toxic substances removing, act gas lift sun, Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang, a few taste is adjuvant drug altogether above, there are broad-spectrum antiseptic and antiviral effect more, be equivalent to antibiotic medicine, and patient can not be made to produce drug resistance, the Radix Astragali, Colla Corii Asini, Fructus Schisandrae Chinensis etc. are nursed one's health health, strengthening the body resistance, patient is made to improve autoimmunity, accelerate the recovery of the state of an illness.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, have clearing away heat and promoting production of body fluid, boosting qi and nourishing yin, lung moistening are calmed the nerves, effect of blood-supplementing blood-nourishing, effectively can treat interstitial lung disease.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Folium Bambusae 7-17 part, Gypsum Fibrosum 19-29 part, Radix Panacis Quinquefolii 4-14 part, Radix Ophiopogonis 7-17 part, Bulbus Lilii 10-20 part, Radix Rehmanniae 13-23 part, Radix Rehmanniae Preparata 13-23 part, Bulbus Fritillariae Thunbergii 7-17 part, Radix Scrophulariae 10-20 part, Radix Angelicae Sinensis 13-23 part, Radix Paeoniae Alba 7-17 part, Radix Platycodonis 10-20 part, Rhizoma Pinelliae 4-14 part, Radix Asparagi 7-17 part, Rhizoma Dioscoreae 10-20 part, Radix Stemonae 7-17 part, Radix Glehniae 10-20 part, Folium Mori 7-17 part, Flos Chrysanthemi 5-15 part, Fructus Schisandrae Chinensis 7-17 part, Colla Corii Asini 4-14 part, Cortex Lycii 15-25 part, Radix Astragali 25-35 part, Rhizoma Cimicifugae 7-17 part, Radix Bupleuri 7-17 part.
Wherein be preferably: 12 parts, Folium Bambusae, Gypsum Fibrosum 24 parts, Radix Panacis Quinquefolii 9 parts, Radix Ophiopogonis 12 parts, Bulbus Lilii 15 parts, Radix Rehmanniae 18 parts, Radix Rehmanniae Preparata 18 parts, Bulbus Fritillariae Thunbergii 12 parts, Radix Scrophulariae 15 parts, Radix Angelicae Sinensis 18 parts, the Radix Paeoniae Alba 12 parts, Radix Platycodonis 15 parts, the Rhizoma Pinelliae 9 parts, Radix Asparagi 12 parts, Rhizoma Dioscoreae 15 parts, the Radix Stemonae 12 parts, Radix Glehniae 15 parts, Folium Mori 12 parts, Flos Chrysanthemi 10 parts, Fructus Schisandrae Chinensis 12 parts, 9 parts, Colla Corii Asini, Cortex Lycii 20 parts, the Radix Astragali 30 parts, Rhizoma Cimicifugae 12 parts, Radix Bupleuri 12 parts.
A kind of preparation method for the treatment of the Chinese medicine preparation of interstitial lung disease is as follows:
Step one: by weight proportion of the present invention, first becomes medicated bag by Fructus Schisandrae Chinensis bundle, is put in water and soaks about 45 minutes, filters, for subsequent use;
Step 2: by weight proportion of the present invention, grinds to 200 mesh sieves by Gypsum Fibrosum, Radix Rehmanniae Preparata, for subsequent use;
Step 3: by weight proportion of the present invention, Xisha is joined, Radix Ophiopogonis, Radix Rehmanniae, Radix Scrophulariae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Platycodonis, Radix Asparagi, Rhizoma Dioscoreae, the Radix Stemonae, Radix Glehniae, the Radix Astragali, Rhizoma Cimicifugae is put into after marmite adds step one immersion and is remained cold water, exceed powder 2 ~ 5 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 3 cm is added in residue medicinal residues, then Bulbus Lilii is added, Bulbus Fritillariae Thunbergii, the Rhizoma Pinelliae, Cortex Lycii, medicated bag in Radix Bupleuri and step one decocts about 30 minutes, add Folium Bambusae afterwards, Folium Mori, Flos Chrysanthemi decocts filtration in 20 minutes, obtain filtrate, merge twice filtrate, filter, waste, for subsequent use,
Step 4: by weight proportion of the present invention, Colla Corii Asini is put in while hot molten in step 3 gained hot soup medicine, then the powder in step 2 is added, medicine soup is carried out concentrate and add ethanol, place precipitation, filter, abandoning precipitation, filtrate recycling ethanol, is the thick paste of relative density 1.15 ~ 1.20 under 75 DEG C of environment by gained concentration of liquid medicine, by air-dry for thick paste pulverizing, add Mel, antiseptic, wetting agent etc., carry out beating, rubbing, one-tenth ball, dry, be distributed into bag, both the honeyed pill for the treatment of interstitial lung disease of the present invention.
The effects such as medicine of the present invention has clearing away heat and promoting production of body fluid, boosting qi and nourishing yin, lung moistening are calmed the nerves, blood-supplementing blood-nourishing, and it is evident in efficacy, cheap, have no side effect, not easily recur, the mode that this Chinese medicine preparation adopts is treated and can be reduced the damage of Western medicine to patient's hepatic and renal function, accelerate the improvement of the state of an illness, according to clinical 240 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 90%, two the total effective rate course for the treatment of 95%.
Detailed description of the invention
Embodiment one, 7 parts, Folium Bambusae, Gypsum Fibrosum 19 parts, Radix Panacis Quinquefolii 4 parts, Radix Ophiopogonis 7 parts, Bulbus Lilii 10 parts, Radix Rehmanniae 13 parts, Radix Rehmanniae Preparata 13 parts, Bulbus Fritillariae Thunbergii 7 parts, Radix Scrophulariae 10 parts, Radix Angelicae Sinensis 13 parts, the Radix Paeoniae Alba 7 parts, Radix Platycodonis 10 parts, the Rhizoma Pinelliae 4 parts, Radix Asparagi 7 parts, Rhizoma Dioscoreae 10 parts, the Radix Stemonae 7 parts, Radix Glehniae 10 parts, Folium Mori 7 parts, Flos Chrysanthemi 5 parts, Fructus Schisandrae Chinensis 7 parts, 4 parts, Colla Corii Asini, Cortex Lycii 15 parts, the Radix Astragali 25 parts, Rhizoma Cimicifugae 7 parts, Radix Bupleuri 7 parts.
Embodiment two, 12 parts, Folium Bambusae, Gypsum Fibrosum 24 parts, Radix Panacis Quinquefolii 9 parts, Radix Ophiopogonis 12 parts, Bulbus Lilii 15 parts, Radix Rehmanniae 18 parts, Radix Rehmanniae Preparata 18 parts, Bulbus Fritillariae Thunbergii 12 parts, Radix Scrophulariae 15 parts, Radix Angelicae Sinensis 18 parts, the Radix Paeoniae Alba 12 parts, Radix Platycodonis 15 parts, the Rhizoma Pinelliae 9 parts, Radix Asparagi 12 parts, Rhizoma Dioscoreae 15 parts, the Radix Stemonae 12 parts, Radix Glehniae 15 parts, Folium Mori 12 parts, Flos Chrysanthemi 10 parts, Fructus Schisandrae Chinensis 12 parts, 9 parts, Colla Corii Asini, Cortex Lycii 20 parts, the Radix Astragali 30 parts, Rhizoma Cimicifugae 12 parts, Radix Bupleuri 12 parts.
Embodiment three, 17 parts, Folium Bambusae, Gypsum Fibrosum 29 parts, Radix Panacis Quinquefolii 14 parts, Radix Ophiopogonis 17 parts, Bulbus Lilii 20 parts, Radix Rehmanniae 23 parts, Radix Rehmanniae Preparata 23 parts, Bulbus Fritillariae Thunbergii 17 parts, Radix Scrophulariae 20 parts, Radix Angelicae Sinensis 23 parts, the Radix Paeoniae Alba 17 parts, Radix Platycodonis 20 parts, the Rhizoma Pinelliae 14 parts, Radix Asparagi 17 parts, Rhizoma Dioscoreae 20 parts, the Radix Stemonae 17 parts, Radix Glehniae 20 parts, Folium Mori 17 parts, Flos Chrysanthemi 15 parts, Fructus Schisandrae Chinensis 17 parts, 14 parts, Colla Corii Asini, Cortex Lycii 25 parts, the Radix Astragali 35 parts, Rhizoma Cimicifugae 17 parts, Radix Bupleuri 17 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data and Therapeutic Method
Accept out-patient 240 example for medical treatment.According to Medications Example two of the present invention, and honeyed pill prepared by preferred preparation method, sooner or later service once, each 2, decoction being taken warmly.It within 10th, is a course for the treatment of.
Two, efficacy assessment standard
1, cure: interstitial lung disease transference cure, pant, cough, other symptoms such as dyspnea also disappear.
2, take a turn for the better: interstitial lung disease symptom obviously alleviates, and body constitution is progressively recovered, and other clinical symptoms are also recovered gradually.
3, do not heal: interstitial lung disease and other clinical symptoms are without any improvement.
Three, therapeutic outcome statistics
As can be seen from above-mentioned, Chinese medicine of the present invention has good clinical effectiveness at treatment interstitial lung disease, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.
Model case and curative effect:
Case one, Wu, female, 46 years old, patient's body constitution is always bad, in recent months, there is dyspnea in patient, and there is the sign increased the weight of, to examination in hospital, visible large stretch of shade in two lung, be diagnosed as interstitial lung disease, through antibiotic medicine symptomatic treatment, but effect is not clearly, patient is pale complexion still, short of breath, and feel nervous, uncomfortable in chest weak, upon somebody's introduction, carry out here treatment, adopt made honeyed pill in the embodiment of the present invention two, after patient takes two courses for the treatment of, interstitial lung disease sensation obviously alleviates, breathe smooth and easy, spirit takes a turn for the better, breathe hard, weak phenomenon obviously alleviates, climb building at ordinary times, obvious eupnea on foot, for consolidate curative effect, continue to take two courses for the treatment of, patient's interstitial lung disease phenomenon disappears completely, other clinical symptoms also disappear completely, climb building, do chores and delay not at all, body constitution also strengthens gradually, follow up a case by regular visits to half a year, have no recurrence, recovery from illness.
Case two, in certain, man, 33 years old, cough, breathe hard, sometimes with heating, about there is the time of 3 months, also there is night sweat in the recent period, other uncomfortable phenomenons such as chest pain, remove examination in hospital, be diagnosed as interstitial lung disease, take antibiotic medicine and some symptomatic drugs, but effect is not clearly, here treatment afterwards, adopt made honeyed pill in the embodiment of the present invention two, after patient takes two courses for the treatment of, interstitial lung disease sensation obviously alleviates, breathe smooth and easy, do not cough not breathe heavily and continue to take a course for the treatment of, patient's interstitial lung disease clinical symptoms disappears completely, body constitution also improves, follow up a case by regular visits to half a year, have no recurrence, recovery from illness.
Case three, Guo, man, 66 years old, patient respiratory difficulty, lip cyanosis, interstitial connective tissues has Fibrotic phenomenon, breathe hard, weak phenomenon is obvious, especially to evening, badly influence rest, patient comes here and goes to a doctor, adopt made honeyed pill in the embodiment of the present invention two, after taking two courses for the treatment of, interstitial lung disease sensation obviously alleviates, sensation of oppression over the chest with shortness of breath phenomenon is also eased, nocturnal cough obviously alleviates, sleep quality is improved, for consolidate curative effect, patient continues to take two courses for the treatment of, patient feels that breathing is smooth and easy, without sense of discomfort, other clinical symptoms also disappear, follow up a case by regular visits to half a year, have no recurrence, recovery from illness.

Claims (4)

1. treat the Chinese medicine composition of interstitial lung disease for one kind, it is characterized in that, this Chinese medicine composition is made up of the medicine of following weight portion: Folium Bambusae 7-17 part, Gypsum Fibrosum 19-29 part, Radix Panacis Quinquefolii 4-14 part, Radix Ophiopogonis 7-17 part, Bulbus Lilii 10-20 part, Radix Rehmanniae 13-23 part, Radix Rehmanniae Preparata 13-23 part, Bulbus Fritillariae Thunbergii 7-17 part, Radix Scrophulariae 10-20 part, Radix Angelicae Sinensis 13-23 part, Radix Paeoniae Alba 7-17 part, Radix Platycodonis 10-20 part, Rhizoma Pinelliae 4-14 part, Radix Asparagi 7-17 part, Rhizoma Dioscoreae 10-20 part, Radix Stemonae 7-17 part, Radix Glehniae 10-20 part, Folium Mori 7-17 part, Flos Chrysanthemi 5-15 part, Fructus Schisandrae Chinensis 7-17 part, Colla Corii Asini 4-14 part, Cortex Lycii 15-25 part, Radix Astragali 25-35 part, Rhizoma Cimicifugae 7-17 part, Radix Bupleuri 7-17 part.
2. the Chinese medicine composition of the treatment interstitial lung disease according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: 12 parts, Folium Bambusae, Gypsum Fibrosum 24 parts, Radix Panacis Quinquefolii 9 parts, Radix Ophiopogonis 12 parts, Bulbus Lilii 15 parts, Radix Rehmanniae 18 parts, Radix Rehmanniae Preparata 18 parts, Bulbus Fritillariae Thunbergii 12 parts, Radix Scrophulariae 15 parts, Radix Angelicae Sinensis 18 parts, the Radix Paeoniae Alba 12 parts, Radix Platycodonis 15 parts, the Rhizoma Pinelliae 9 parts, Radix Asparagi 12 parts, Rhizoma Dioscoreae 15 parts, the Radix Stemonae 12 parts, Radix Glehniae 15 parts, Folium Mori 12 parts, Flos Chrysanthemi 10 parts, Fructus Schisandrae Chinensis 12 parts, 9 parts, Colla Corii Asini, Cortex Lycii 20 parts, the Radix Astragali 30 parts, Rhizoma Cimicifugae 12 parts, Radix Bupleuri 12 parts.
3. the Chinese medicine preparation for the treatment of interstitial lung disease according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is pill.
4. treat a preparation method for the Chinese medicine preparation of interstitial lung disease, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, first Fructus Schisandrae Chinensis bundle is become medicated bag, is put in water and soaks about 45 minutes, filters, for subsequent use, step 2: by weight proportion of the present invention, grinds to 200 mesh sieves by Gypsum Fibrosum, Radix Rehmanniae Preparata, for subsequent use, step 3: by weight proportion of the present invention, Xisha is joined, Radix Ophiopogonis, Radix Rehmanniae, Radix Scrophulariae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Platycodonis, Radix Asparagi, Rhizoma Dioscoreae, the Radix Stemonae, Radix Glehniae, the Radix Astragali, Rhizoma Cimicifugae is put into after marmite adds step one immersion and is remained cold water, exceed powder 2 ~ 5 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 3 cm is added in residue medicinal residues, then Bulbus Lilii is added, Bulbus Fritillariae Thunbergii, the Rhizoma Pinelliae, Cortex Lycii, medicated bag in Radix Bupleuri and step one decocts about 30 minutes, add Folium Bambusae afterwards, Folium Mori, Flos Chrysanthemi decocts filtration in 20 minutes, obtain filtrate, merge twice filtrate, filter, waste, for subsequent use, step 4: by weight proportion of the present invention, Colla Corii Asini is put in while hot molten in step 3 gained hot soup medicine, then the powder in step 2 is added, medicine soup is carried out concentrate and add ethanol, place precipitation, filter, abandoning precipitation, filtrate recycling ethanol, is the thick paste of relative density 1.15 ~ 1.20 under 75 DEG C of environment by gained concentration of liquid medicine, by air-dry for thick paste pulverizing, add Mel, antiseptic, wetting agent etc., carry out beating, rubbing, one-tenth ball, dry, be distributed into bag, both the honeyed pill for the treatment of interstitial lung disease of the present invention.
CN201510005464.6A 2015-01-07 2015-01-07 Traditional Chinese medicine composition for treating interstitial lung disease and preparation method of composition Pending CN104606600A (en)

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CN107596109A (en) * 2017-10-16 2018-01-19 辽宁中医药大学 A kind of Chinese medicine preparation for treating idiopathic pulmonary fibrosis paracmasis disease and preparation method thereof
CN108324833A (en) * 2018-04-28 2018-07-27 山东中医药大学附属医院 A kind of Chinese medicine preparation for treating Connective Tissue Disease interstitial lung disease

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107596109A (en) * 2017-10-16 2018-01-19 辽宁中医药大学 A kind of Chinese medicine preparation for treating idiopathic pulmonary fibrosis paracmasis disease and preparation method thereof
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Application publication date: 20150513