CN101884776B - Chinese preparation for treating hand-foot-and-mouth diseases - Google Patents
Chinese preparation for treating hand-foot-and-mouth diseases Download PDFInfo
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Abstract
The invention discloses a Chinese preparation for treating hand-foot-and-mouth diseases, which comprises a medicament for oral administration and a medicament for external use, wherein the medicament for oral administration is prepared from liquorice root, golden thread, ginger, Chinese thorowax root, willow leaf, sunflower, mongolian dandelion herb, fig, boxthorn leaf, turnip, eggplant, mint and alum by compatibility; and the medicament for external use is prepared from mountain tobacco, the willow leaf, the mongolian dandelion herb, the fig, medlar, earthworm, philippine violet herb, honeysuckle, densefruit pittany root-bark, hairyvein agrimonia herb and bud, calomel, camphor, borneol and tea root by compatibility. The Chinese preparation is prepared by taking traditional Chinese medicines as raw materials and applying the theory of traditional Chinese medical science. By emphasizing heat clearing, detoxication and xeransis, adopting the combination of tonification and purgation, qi and yin tonifying, heat clearing and vein relaxing, the preparation for treating the hand-foot-and-mouth diseases ensures curative effect, achieves the effects of the treatment of both symptoms and root causes and avoids relapse prevention after curing.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease, belong to the field of Chinese medicines.
Background technology
The foot stomatosis is the infectious disease that is caused by enterovirus, and pilosity is born in child below 5 years old, can cause the herpes at positions such as hands, foot, oral cavity, and the minority infant can cause complication such as myocarditis, pulmonary edema, AME.If indivedual serious symptom infant PD are fast, cause death.The enterovirus that causes hand-foot-mouth disease has kind more than 20 (type), 16,4,5,9,10 types of CA group, 2,5 types of B group, and enterovirns type 71 is the more common pathogen of hand-foot-mouth disease, and is wherein common with coxsackie virus A 16-type (Cox A16) and enterovirns type 71 (EV 71).
Aspect treatment, primary disease is as no complication, and prognosis is generally good, how to fully recover in a week.The Therapeutic Principle is mainly symptomatic treatment.Can take antiviral drugs and heat-clearing and detoxifying herb and vitamin B, C etc.But patient's intramuscular injection gamma-globulin that complication is arranged.During one's sickness, should strengthen the nursing of infant, perform oral hygiene.Available normal saline or eliminating cold for resuscitation water are gargled before and after the feed, and food is advisable with liquid and nonirritant food such as semi-fluid.Hand-foot-mouth disease because of can merge myocarditis, encephalitis, meningitis, the property paralysis etc. of speeding, so should strengthen observing, can not adopt a casual attitude in order to avoid recur.
Summary of the invention
A kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease of the present invention is made up of oral medicine and medicine for external use, and wherein oral medicine is to be made by the herbal raw material of following weight proportion:
Radix Glycyrrhizae 10-25 part, Rhizoma Coptidis 10-25 part, Rhizoma Zingiberis Recens 10-25 part, Radix Bupleuri 15-20 part,
Folium Salicis Babylonicae 15-20 part, Flos Helianthi 15-20 part, Herba Taraxaci 8-15 part, Fructus Fici 8-15 part,
Folium Lycii 8-15 part, Radix Brassicae rapae 5-10 part, Fructus Solani melongenae 5-10 part, Herba Menthae 5-10 part,
Alumen 5-10 part;
The preparation method of oral medicine:
Pressing formula proportion cleans Radix Glycyrrhizae, Rhizoma Coptidis, Rhizoma Zingiberis Recens, Radix Bupleuri, Folium Salicis Babylonicae, Flos Helianthi, Herba Taraxaci, Fructus Fici, Folium Lycii, Radix Brassicae rapae, Fructus Solani melongenae, Herba Menthae, the adding Alumen is put into marmite and was boiled 15-20 minute in big fire, extract supernatant, changing slow fire (boil and carry twice) into gets to boil for twice and puts on clear liquid and be in harmonious proportion evenly bottling, place the disinfecting container of high temperature 〉=100 ℃ to carry out disinfection, get product;
Medicine for external use is to be made by the herbal raw material of following weight proportion:
Folium solani verbascifolii 30-60 part, Folium Salicis Babylonicae 30-60 part, Herba Taraxaci 30-60 part, Fructus Fici 30-60 part,
Fructus Lycii 20-50 part, Lumbricus 20-50 part, Herba Violae 20-50 part, Flos Lonicerae 20-50 part,
Cortex Dictamni 10-40 part, Herba Agrimoniae 10-40 part, Camphora 10-40 part, Calomelas 5-30 part,
Radix Camelliae sinensis 5-30 part, Borneolum Syntheticum 5-30 part;
The preparation method of medicine for external use:
(1) it is standby to 200-300 order smalls with Camphora, Borneolum Syntheticum pulverize separately to press formula proportion;
(2) pressing formula proportion cleans Folium solani verbascifolii, Folium Salicis Babylonicae, Herba Taraxaci, Fructus Fici, Fructus Lycii, Lumbricus, Herba Violae, Flos Lonicerae, Cortex Dictamni, Herba Agrimoniae, Radix Camelliae sinensis, add the twice water gaging, soaked 2-3 hour, adding Calomelas and Camphora, Borneolum Syntheticum smalls stir, and put in the saucepan to decoct 1-2 hour, filtered while hot, be cooled to room temperature, left standstill 1 hour, get supernatant and be in harmonious proportion even filling bottle, place the disinfecting container of high temperature 〉=100 ℃ to carry out disinfection, packing promptly gets the medicine for external use finished product.
A kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease of the present invention is made up of oral medicine and medicine for external use, and wherein oral medicine is to be made by the herbal raw material of following weight proportion:
Oral medicine is to be made by following Chinese medicine raw materials by weight proportion:
Radix Glycyrrhizae 12-22 part, Rhizoma Coptidis 12-22 part, Rhizoma Zingiberis Recens 12-22 part, Radix Bupleuri 16-19 part,
Folium Salicis Babylonicae 16-19 part, Flos Helianthi 16-19 part, Herba Taraxaci 9-13 part, Fructus Fici 9-13 part,
Folium Lycii 9-13 part, Radix Brassicae rapae 6-9 part, Fructus Solani melongenae 6-9 part, Herba Menthae 6-9 part,
Alumen 6-9 part;
Medicine for external use is to be made by the herbal raw material of following weight proportion:
Folium solani verbascifolii 35-55 part, Folium Salicis Babylonicae 35-55 part, Herba Taraxaci 35-55 part, Fructus Fici 35-55 part,
Fructus Lycii 25-45 part, Lumbricus 25-45 part, Herba Violae 25-45 part, Flos Lonicerae 25-45 part,
Cortex Dictamni 15-35 part, Herba Agrimoniae 15-35 part, Camphora 15-35 part, Calomelas 9-25 part,
Radix Camelliae sinensis 9-25 part, Borneolum Syntheticum 9-25 part.
A kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease of the present invention is made up of oral medicine and medicine for external use, and wherein oral medicine is to be made by the herbal raw material of following weight proportion:
Oral medicine is to be made by following Chinese medicine raw materials by weight proportion:
20 parts in Radix Glycyrrhizae, 20 parts of Rhizoma Coptidis, 20 parts in Rhizoma Zingiberis Recens, 18 parts of Radix Bupleuri,
18 parts of Folium Salicis Babylonicaves, 18 parts of Flos Helianthis, 10 parts of Herba Taraxacis, 10 parts of Fructus Ficis,
10 parts of Folium Lyciis, 8 parts of Radix Brassicae rapaes, 8 parts of Fructus Solani melongenaes, 8 parts of Herba Menthaes,
8 parts of Alumens;
Medicine for external use is to be made by the herbal raw material of following weight proportion:
45 parts of Folium solani verbascifoliis, 45 parts of Folium Salicis Babylonicaves, 45 parts of Herba Taraxacis, 45 parts of Fructus Ficis,
35 parts of Fructus Lycii, 35 parts of Lumbricuss, 35 parts of Herba Violaes, 35 parts of Flos Loniceraes,
25 parts of Cortex Dictamni, 25 parts of Herba Agrimoniaes, 25 parts of Camphoras, 15 parts of Calomelass,
15 parts of Radix Camelliae sinensiss, 15 parts of Borneolum Syntheticums.
The pharmacology and the property of medicine of Chinese medicine used herein are as follows:
Radix Glycyrrhizae: sweet in the mouth is flat, and effect: invigorating the spleen and replenishing QI, lung moistening are eliminated the phlegm, heat-clearing and toxic substances removing.
Rhizoma Coptidis: hardship, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.
Rhizoma Zingiberis Recens: acrid in the mouth, tepor, nontoxic; Go into lung, the heart, stomach, spleen four warps.Deliver, cold expelling, preventing or arresting vomiting is opened expectorant, carbuncle skin ulcer.
Radix Bupleuri: hardship is slightly cold.Return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, and soothing the liver, yang invigorating.Be used for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
Folium Salicis Babylonicae: [nature and flavor] are " detailed outline " 1.: hardship, and cold, nontoxic.[return through] " book on Chinese herbal medicine is new again ": the willow head is gone into the heart, spleen two warps.The effect of Folium Salicis Babylonicae [function cures mainly-] heat clearing away, rash, diuresis, detoxifcation.Yellow leaf dampness.It is not smooth to control saturating of acute diseases such as cholera and sunstroke rash, nebulousurine, and the furuncle furuncle and phyma, mastitis, goiter, erysipelas is scalded, toothache.
Flos Helianthi: it is little sweet to distinguish the flavor of; Property is put down.Function cures mainly: dispel the wind; Suppressing the hyperactive liver; Dampness removing.Main dizzy; Tinnitus; Dribbling urination." glossary of Herbs and Drugs commonly used among the people ": " dispel the wind, make eye bright.Control giddy, swelling of the face can expedite the emergence of again." the water extract perfusion rabbit ear of flower has vasorelaxation action; Injection under the cat skin there is of short duration hypotensive effect; To excited, the blood pressure drops of intravenous rabbit injection also causing breathing, can also obviously strengthen small intestinal and shrink, can be used for anenterneuria.Tincture has antipyretic effect according to cloud.
Herba Taraxaci: sweet, little hardship, cold.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Cure mainly: upper respiratory tract infection, eye conjunctivitis, mumps, acute mastitis swells and ache, gastritis, dysentery, hepatitis, gallbladder is assisted inflammation, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis is controlled acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.
Fructus Fici: sweet in the mouth, flat; Function: nourishing the lung to arrest cough, clearing away heat and moistening the bowels: be used for cough with asthma, laryngopharynx swelling and pain, constipation, hemorrhoid.
Folium Lycii: bitter sweet, cold.1. " property of medicine opinion ": " sweet in the mouth, flat." 2. " a thousand pieces of gold dietetic therapy ": " and bitter in the mouth, flat, puckery, nontoxic.Effect cures mainly: the liver and the kidney tonifying, promoting the production of body fluid to quench thirst, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling.Control deficient fever, excessive thirst, conjunctival congestion are lost consciousness bitterly, the nyctalopia of hiding from view, bleeding not during menses, hot carbuncle toxin.
Radix Brassicae rapae: [nature and flavor] toil is sweet, and is flat, nontoxic.[function cures mainly] appetizing therapeutic method to keep the adverse QI flowing downwards, eliminating damp, detoxifying.Control accumulation of food in the stomach and intes tine due to indigestion, jaundice is quenched one's thirst, pyretic toxicity swelling due to wind, furuncle, acute mastitis.
Fructus Solani melongenae: Fructus Solani melongenae sweet in the mouth, cool in nature, go into spleen, stomach, large intestine channel; Has clearing away heat to stop bleeding, the effect of reducing swelling and alleviating pain; Be used for pyretic toxicity carbuncle skin ulcer, skin ulcer, aphtha of the mouth and tongue, hemorrhoid hematochezia, have blood in stool, epistaxis etc.
Herba Menthae: cool in nature, acrid in the mouth; Function: the irritation effect causes trachea to produce new secretion, and makes stiff mucus be easy to get rid of, so eliminate the phlegm, germ-resistant effect; " the southern regions of the Yunnan Province book on Chinese herbal medicine ": control all typhoid fever headaches, cholera is vomited and diarrhoea, carbuncle, cellulitis, scabies, insane all skin ulcers.Again: all wind of refresh oneself on the wild mint, end headache, dizzy, heating.
Alumen: sour in the mouth, cold.Go into spleen channel.Function: the sputum of vomiting and diarrhea wind heat, get its sour and bitter flavors can cause of vomiting and diarrhea also; Control all disorders of blood, proctoptosis, the prolapse of the uterus, skin infection, get that it is sour and astringent and receive also; Control phlegm retention, let out profit, metrorrhagia and leukorrhagia, wind-eye, get its receipts and dampness also; Control sore throat, carbuncle of yin nature, middle legendary venomous insect, snakeworm and hinder Trionyx sinensis Wiegmann, get its detoxifcation also.
Folium solani verbascifolii: suffering, flat.It is swollen to harness the Yellow River, gout, metrorrhagia, treating swelling and pain by traumatic injury, toothache, scrofula, carbuncle skin ulcer, eczema, dermatitis.Parasite killing, detumescence, hemostasis.
Fructus Lycii: sweet, flat, go into liver, stomach two warps, doublely go into lung meridian; Function cures mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.Cure mainly: it is dizzy to control apoplexy, and asthenia is allly seen blood disorder, cough blood, flaccidity, faint, contraction, the miasma that disappears is hindered dryly, passes out semen reddish and whitish turbid urine, beriberi, the arthroncus of knee.
Lumbricus: Chinese medicine also claims Pheretima, Pheretima salty in the mouth cold in nature.Its salty in the mouth, cold in nature.Function is heat clearing away, spasmolytic, Zhichuan, diuresis.Cure mainly that hyperpyrexia is manic, convulsion with spasms, headache conjunctival congestion, the diseases such as expectorant heat, apoplexy, hemiplegia of panting.
Herba Violae: bitter, hot, cold, nontoxic; GUIXIN, Liver Channel.Function cures mainly: can be used as medicine its mildly bitter flavor cold in nature, heat-clearing and toxic substances removing, removing heat from blood detumescence.Cure mainly jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis; Traumatic injury, carbuncle, venom etc. are controlled in external application.
Flos Lonicerae: property is sweet, cold; Function: heat clearing away, detoxifcation, antiinflammatory, antibiotic effect are arranged.Compendium of Material Medica is carried " Flos Lonicerae is good at removing toxic substances, so control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating of treatment epidemic febrile disease, and toxic-heat and blood stasis, diseases such as carbuncle and ulcer also are used for diseases such as anemopyretic cold, bronchitis.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, analgesic, regulate effect such as immunity.
Cortex Dictamni: bitter cold, go into spleen, the stomach warp.Function: heat-clearing and toxic substances removing, expelling wind and removing dampness.Be used for diseases such as damp and hot sore, rubella, scabies, skin scratch, arthralgia chiefly caused by damp pathogen, jaundice.
Herba Agrimoniae: toil, flat, go into lung, liver, spleen channel; Effect: stop blooding, be good for the stomach; Cure mainly: spitting of blood, haematemesis, hematuria, have blood in stool, " record of Chinese herbal medicine handbook and raw tortoise plastron etc. have been decocted in water for oral dose and had controlled the anaphylactoid purpura effect doctor of Soviet Union.
Camphora: suffering, temperature.Cure mainly: sensible ward off dirty, warming middle-JIAO to relieve pain, dampness removing parasite killing.Be used for cold-damp and vomit and diarrhoea stomach abdomen pain; External is controlled scabies, tinea, dental caries and is had a pain.
Calomelas: [nature and flavor] suffering, cold, poisonous.[return through] goes into liver, kidney channel.[function] parasite killing, counteracting toxic substances, diuretic, relieving constipation.Control scabies, scrofula, syphilis, primary sore, skin ulcer, edema, tympanites, defecation is closed.
Radix Camelliae sinensis: hardship; Cool.GUIXIN; Kidney channel.The heart tonifying diuresis; Promoting blood flow to regulate menstruation; Heat-clearing and toxic substances removing.Cure mainly: heart disease; Edema; Hepatitis; Dysmenorrhea; Sore swollen toxin; Aphtha; The soup fire is burnt; Herpes zoster; Psoriasis.
Borneolum Syntheticum: acrid in the mouth, hardship are slightly cold.GUIXIN, spleen, the lung hydrocarbon.Effect: the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.
Excellent effect of the present invention: the present invention uses the traditional Chinese medicine of China to be raw material, and forms by clinic tests and repeated verification configuration, meets the theory of Chinese medicine.Grasping with oral Chinese medicine is that this cooperation external Chinese medicine carries out comprehensive Comprehensive Treatment, its Chinese medicine preparation has been avoided the side reaction of western medicine therapy single effect, be particular about integrally-regulated, though hand-foot-mouth disease occurs in the part, but indivisible the contact arranged with integral body, integrality how, to the local patholoic change influence greatly, adjust general body state, very important to the treatment local patholoic change, Just because of this, Chinese medicine preparation treatment hand-foot-mouth disease of the present invention is emphasized heat-clearing and toxic substances removing, dehumidifying, advocates reinforcement and elimination in combination, supplementing QI and nourishing YIN heat clearing away collateral dredging again simultaneously; Can guarantee curative effect like this, reach treating both the principal and secondary aspects of a disease, more the back is difficult for recurrence.
The specific embodiment:
Embodiment 1, prescription:
Oral medicine: Radix Glycyrrhizae 10g, Rhizoma Coptidis 10g, Rhizoma Zingiberis Recens 10g, Radix Bupleuri 15g, Folium Salicis Babylonicae 15g, Flos Helianthi 15g, Herba Taraxaci 8g, Fructus Fici 8g, Folium Lycii 8g, Radix Brassicae rapae 5g, Fructus Solani melongenae 5g, Herba Menthae 5g, Alumen 5g;
The preparation method of oral medicine:
Pressing formula proportion cleans Radix Glycyrrhizae, Rhizoma Coptidis, Rhizoma Zingiberis Recens, Radix Bupleuri, Folium Salicis Babylonicae, Flos Helianthi, Herba Taraxaci, Fructus Fici, Folium Lycii, Radix Brassicae rapae, Fructus Solani melongenae, Herba Menthae, the adding Alumen is put into marmite and was boiled 15-20 minute in big fire, extract supernatant, changing slow fire (boil and carry twice) into gets to boil for twice and puts on clear liquid and be in harmonious proportion evenly bottling, place the disinfecting container of high temperature 〉=100 ℃ to carry out disinfection, get product;
Medicine for external use: Folium solani verbascifolii 30g, Folium Salicis Babylonicae 30g, Herba Taraxaci 30g, Fructus Fici 30g, Fructus Lycii 20g, Lumbricus 20g, Herba Violae 20g, Flos Lonicerae 20g, Cortex Dictamni 10g, Herba Agrimoniae 10g, Camphora 10g, Calomelas 5g, Radix Camelliae sinensis 5g, Borneolum Syntheticum 5g;
The preparation method of medicine for external use:
(1) it is standby to 200-300 order smalls with Camphora, Borneolum Syntheticum pulverize separately to press formula proportion;
(2) pressing formula proportion cleans Folium solani verbascifolii, Folium Salicis Babylonicae, Herba Taraxaci, Fructus Fici, Fructus Lycii, Lumbricus, Herba Violae, Flos Lonicerae, Cortex Dictamni, Herba Agrimoniae, Radix Camelliae sinensis, add the twice water gaging, soaked 2-3 hour, adding Calomelas and Camphora, Borneolum Syntheticum smalls stir, and put in the saucepan to decoct 1-2 hour, filtered while hot, be cooled to room temperature, left standstill 1 hour, get supernatant and be in harmonious proportion even filling bottle, place the disinfecting container of high temperature 〉=100 ℃ to carry out disinfection, packing promptly gets the medicine for external use finished product.
Embodiment 2, prescription:
Oral medicine: Radix Glycyrrhizae 12g, Rhizoma Coptidis 12g, Rhizoma Zingiberis Recens 12g, Radix Bupleuri 16g, Folium Salicis Babylonicae 16g, Flos Helianthi 16g, Herba Taraxaci 9g, Fructus Fici 9g, Folium Lycii 9g, Radix Brassicae rapae 6g, Fructus Solani melongenae 6g, Herba Menthae 6g, Alumen 6g;
Medicine for external use: Folium solani verbascifolii 35g, Folium Salicis Babylonicae 35g, Herba Taraxaci 35g, Fructus Fici 35g, Fructus Lycii 25g, Lumbricus 25g, Herba Violae 25g, Flos Lonicerae 25g, Cortex Dictamni 15g, Herba Agrimoniae 15g, Camphora 15g, Calomelas 9g, Radix Camelliae sinensis 9g, Borneolum Syntheticum 9g;
Preparation method is identical with embodiment 1.
Embodiment 3, prescription:
Oral medicine: Radix Glycyrrhizae 20g, Rhizoma Coptidis 20g, Rhizoma Zingiberis Recens 20g, Radix Bupleuri 18g, Folium Salicis Babylonicae 18g, Flos Helianthi 18g, Herba Taraxaci 10g, Fructus Fici 10g, Folium Lycii 10g, Radix Brassicae rapae 8g, Fructus Solani melongenae 8g, Herba Menthae 8g, Alumen 8g;
Medicine for external use: Folium solani verbascifolii 45g, Folium Salicis Babylonicae 45g, Herba Taraxaci 45g, Fructus Fici 45g, Fructus Lycii 35g, Lumbricus 35g, Herba Violae 35g, Flos Lonicerae 35g, Cortex Dictamni 25g, Herba Agrimoniae 25g, Camphora 25g, Calomelas 15g, Radix Camelliae sinensis 15g, Borneolum Syntheticum 15g;
Preparation method is identical with embodiment 1.
Embodiment 4, prescription:
Oral medicine: Radix Glycyrrhizae 22g, Rhizoma Coptidis 22g, Rhizoma Zingiberis Recens 22g, Radix Bupleuri 19g, Folium Salicis Babylonicae 19g, Flos Helianthi 19g, Herba Taraxaci 13g, Fructus Fici 13g, Folium Lycii 13g, Radix Brassicae rapae 9g, Fructus Solani melongenae 9g, Herba Menthae 9g, Alumen 9g;
Medicine for external use: Folium solani verbascifolii 55g, Folium Salicis Babylonicae 55g, Herba Taraxaci 55g, Fructus Fici 55g, Fructus Lycii 45g, Lumbricus 45g, Herba Violae 45g, Flos Lonicerae 45g, Cortex Dictamni 35g, Herba Agrimoniae 35g, Camphora 35g, Calomelas 25g, Radix Camelliae sinensis 25g, Borneolum Syntheticum 25g.
Preparation method is identical with embodiment 1.
Embodiment 5, prescription:
Oral medicine: Radix Glycyrrhizae 25g, Rhizoma Coptidis 25g, Rhizoma Zingiberis Recens 25g, Radix Bupleuri 20g, Folium Salicis Babylonicae 20g, Flos Helianthi 20g, Herba Taraxaci 15g, Fructus Fici 15g, Folium Lycii 15g, Radix Brassicae rapae 10g, Fructus Solani melongenae 10g, Herba Menthae 10g, Alumen 10g;
Medicine for external use: Folium solani verbascifolii 60g, Folium Salicis Babylonicae 60g, Herba Taraxaci 60g, Fructus Fici 60g, Fructus Lycii 50g, Lumbricus 50g, Herba Violae 50g, Flos Lonicerae 50g, Cortex Dictamni 40g, Herba Agrimoniae 40g, Camphora 40g, Calomelas 30g, Radix Camelliae sinensis 30g, Borneolum Syntheticum 30g;
Preparation method is identical with embodiment 1.
Therapeutic effect and curative effect:
The invention belongs to the pure Chinese medicinal preparation medicine, be particular about integrally-regulated, though hand-foot-mouth disease occurs in the part, with integral body indivisible the contact arranged, integrality is how, to the local patholoic change influence greatly, adjust general body state, very important to the treatment local patholoic change, Just because of this, Chinese medicine preparation treatment hand-foot-mouth disease of the present invention is emphasized heat-clearing and toxic substances removing, dehumidifying, advocates reinforcement and elimination in combination, supplementing QI and nourishing YIN heat clearing away collateral dredging again simultaneously; Dispelling wind-heat, heat-clearing and toxic substances removing enhances metabolism at last, adjusts general body state and makes the patient obtain rehabilitation then, can guarantee curative effect like this, reaches treating both the principal and secondary aspects of a disease, and more the back is difficult for recurrence.
This group is selected into model case 28 examples and carries out statistical analysis, wherein male 19 examples, women 9 examples.Age of onset:＜1 years old person's 1 example ,≤2 years old person's 19 example ,≤3 years old person's 3 example ,≤4 years old person's 1 example ,≤5 years old person's 1 example,＞5 years old person's 3 example, the age of onset reckling is 11 months, the maximum age is 8 years old.Morbidity is all arranged throughout the year, with spring, summer be onset peak period.
The treatment standard: heating is disappeared, and the skin ulcer rash is shrivelled, and oral ulcer heals fully, and erythra disappears fully.
Therapeutic outcome: through in time isolating, after early stage a series of treatments and the nursing, 28 examples are all cured.
By to the clinical observation after hundreds of routine patient's medications, cured substance rate of the present invention is up to more than 97%.Sum up by patient's tracing observation is analyzed and researched, the patient more than 93% thinks that this medical instrument has unique curative effect.
Model case:
Case 1:
1 years old half cardinal symptom of Distributions in Liaocheng of Shandong Province patient is heating, micro evil wind, cough, nasal obstruction watery nasal discharge, and a large amount of herpess appear in hand-foot skin, pars oralis pharyngis, local pruritus, nauseating, the symptom of having loose bowels is arranged, and thin white fur of tongue should refrigerant inducing sweat with Chinese medicine preparation of the present invention treatment, dispelling wind and heat pathogens, recovery from illness after 10 days.
Case 2:
There is red pimple shape the buccal in 2 years old oral cavity of Fei County, Shandong patient, and is peaceful with sleeping at heating, dysphoria, night, yellowish urine is red,, takes effect the complete obiteration of 5 days red pimple shapes, now rehabilitation in 2 days through being diagnosed as hand-foot-mouth disease with Chinese medicine preparation of the present invention.
Case 3:
2 years old half position such as brothers' heart, elbow, knee joint, buttocks and external genitalia of Heze, Shandong patient small rice grain size, rubescent canescence exanthema vesiculosum on every side all occur, with heating; Through being diagnosed as hand-foot-mouth disease, took effect in 1 day with Chinese medicine preparation of the present invention, after 3 days, the complete obiteration of red pimple shape, now rehabilitation.
Case 4:
Juye, Shandong patient was positioned at tongue in 4 years old and there is vesicle two buccals, and blush is arranged on every side, through being diagnosed as hand-foot-mouth disease, took effect in 2 days with Chinese medicine preparation of the present invention, and after 5 days, the complete obiteration of red pimple shape, now rehabilitation.
Case 5:
Positions such as 2 years old buttocks of Jinan, Shandong Huaiyin District patient and external genitalia Semen phaseoli radiati grain size, rubescent canescence exanthema vesiculosum on every side all occur, with heating; Through being diagnosed as hand-foot-mouth disease, took effect in 1 day with Chinese medicine preparation of the present invention, after 3 days, the complete obiteration of red pimple shape, now rehabilitation.
Case 6:
There is red pimple shape the buccal in 5 years old oral cavity of Jinan, Shandong patient, and is peaceful with sleeping at heating, dysphoria, night, yellowish urine is red,, takes effect the complete obiteration of 7 days red pimple shapes, now rehabilitation in 3 days through being diagnosed as hand-foot-mouth disease with Chinese medicine preparation of the present invention.
Case 7:
3 years old half cardinal symptom of Jinan, Shandong Licheng District patient is cough, nasal obstruction watery nasal discharge, and a large amount of herpess appear in hand-foot skin, pars oralis pharyngis, and local pruritus has nauseating, the symptom of having loose bowels, should refrigerant inducing sweat with Chinese medicine preparation treatment of the present invention, and dispelling wind and heat pathogens was fully recovered after 7 days.
Case 8:
Tai'an, Shandong patient was positioned at tongue in 1 years old and there is vesicle two buccals, and blush is arranged on every side, through being diagnosed as hand-foot-mouth disease, took effect in 2 days with Chinese medicine preparation of the present invention, and after 5 days, the complete obiteration of red pimple shape, now rehabilitation.
Case 9:
Jinan, Shandong Lixia District patient was positioned at tongue in 2 years old and there is vesicle two buccals, and blush is arranged on every side, and the herpes ulceration, through being diagnosed as hand-foot-mouth disease, took effect in 4 days with Chinese medicine preparation of the present invention, and after 7 days, the complete obiteration of red pimple shape, now rehabilitation.
Case 10:
Semen phaseoli radiati size exanthema vesiculosum appears in 2 years old half lip inboard of Jinan, Shandong patient, and usually sialorrhea can not be eaten through being diagnosed as hand-foot-mouth disease, took effect in 3 days with Chinese medicine preparation of the present invention, and after 5 days, the complete obiteration of red pimple shape, now rehabilitation.
Claims (3)
1. a Chinese medicine preparation for the treatment of hand-foot-mouth disease comprises oral medicine and medicine for external use, it is characterized in that, oral medicine is to be made by the herbal raw material of following weight proportion:
Radix Glycyrrhizae 10-25 part, Rhizoma Coptidis 10-25 part, Rhizoma Zingiberis Recens 10-25 part, Radix Bupleuri 15-20 part,
Folium Salicis Babylonicae 15-20 part, Flos Helianthi 15-20 part, Herba Taraxaci 8-15 part, Fructus Fici 8-15 part,
Folium Lycii 8-15 part, Radix Brassicae rapae 5-10 part, Fructus Solani melongenae 5-10 part, Herba Menthae 5-10 part,
Alumen 5-10 part;
The preparation method of oral medicine:
Pressing formula proportion cleans Radix Glycyrrhizae, Rhizoma Coptidis, Rhizoma Zingiberis Recens, Radix Bupleuri, Folium Salicis Babylonicae, Flos Helianthi, Herba Taraxaci, Fructus Fici, Folium Lycii, Radix Brassicae rapae, Fructus Solani melongenae, Herba Menthae, the adding Alumen is put into marmite and was boiled 15-20 minute in big fire, extract supernatant, changing slow fire into boils and carries twice, get to boil for twice and put on evenly bottling of clear liquid mediation, place the disinfecting container of high temperature 〉=100 ℃ to carry out disinfection, get product;
Medicine for external use is to be made by the herbal raw material of following weight proportion:
Folium solani verbascifolii 30-60 part, Folium Salicis Babylonicae 30-60 part, Herba Taraxaci 30-60 part, Fructus Fici 30-60 part,
Fructus Lycii 20-50 part, Lumbricus 20-50 part, Herba Violae 20-50 part, Flos Lonicerae 20-50 part,
Cortex Dictamni 10-40 part, Herba Agrimoniae 10-40 part, Camphora 10-40 part, Calomelas 5-30 part,
Radix Camelliae sinensis 5-30 part, Borneolum Syntheticum 5-30 part;
The preparation method of medicine for external use:
(1) it is standby to 200-300 order smalls with Camphora, Borneolum Syntheticum pulverize separately to press formula proportion;
(2) pressing formula proportion cleans Folium solani verbascifolii, Folium Salicis Babylonicae, Herba Taraxaci, Fructus Fici, Fructus Lycii, Lumbricus, Herba Violae, Flos Lonicerae, Cortex Dictamni, Herba Agrimoniae, Radix Camelliae sinensis, add the twice water gaging, soaked 2-3 hour, adding Calomelas and Camphora, Borneolum Syntheticum smalls stir, and put in the saucepan to decoct 1-2 hour, filtered while hot, be cooled to room temperature, left standstill 1 hour, get supernatant and be in harmonious proportion even filling bottle, place the disinfecting container of high temperature 〉=100 ℃ to carry out disinfection, packing promptly gets the medicine for external use finished product.
2. a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease according to claim 1 is characterized in that,
Oral medicine is to be made by following Chinese medicine raw materials by weight proportion:
Radix Glycyrrhizae 12-22 part, Rhizoma Coptidis 12-22 part, Rhizoma Zingiberis Recens 12-22 part, Radix Bupleuri 16-19 part,
Folium Salicis Babylonicae 16-19 part, Flos Helianthi 16-19 part, Herba Taraxaci 9-13 part, Fructus Fici 9-13 part,
Folium Lycii 9-13 part, Radix Brassicae rapae 6-9 part, Fructus Solani melongenae 6-9 part, Herba Menthae 6-9 part,
Alumen 6-9 part;
Medicine for external use is to be made by the herbal raw material of following weight proportion:
Folium solani verbascifolii 35-55 part, Folium Salicis Babylonicae 35-55 part, Herba Taraxaci 35-55 part, Fructus Fici 35-55 part,
Fructus Lycii 25-45 part, Lumbricus 25-45 part, Herba Violae 25-45 part, Flos Lonicerae 25-45 part,
Cortex Dictamni 15-35 part, Herba Agrimoniae 15-35 part, Camphora 15-35 part, Calomelas 9-25 part,
Radix Camelliae sinensis 9-25 part, Borneolum Syntheticum 9-25 part.
3. a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease according to claim 2 is characterized in that,
Oral medicine is to be made by following Chinese medicine raw materials by weight proportion:
20 parts in Radix Glycyrrhizae, 20 parts of Rhizoma Coptidis, 20 parts in Rhizoma Zingiberis Recens, 18 parts of Radix Bupleuri,
18 parts of Folium Salicis Babylonicaves, 18 parts of Flos Helianthis, 10 parts of Herba Taraxacis, 10 parts of Fructus Ficis,
10 parts of Folium Lyciis, 8 parts of Radix Brassicae rapaes, 8 parts of Fructus Solani melongenaes, 8 parts of Herba Menthaes,
8 parts of Alumens;
Medicine for external use is to be made by the herbal raw material of following weight proportion:
45 parts of Folium solani verbascifoliis, 45 parts of Folium Salicis Babylonicaves, 45 parts of Herba Taraxacis, 45 parts of Fructus Ficis,
35 parts of Fructus Lycii, 35 parts of Lumbricuss, 35 parts of Herba Violaes, 35 parts of Flos Loniceraes,
25 parts of Cortex Dictamni, 25 parts of Herba Agrimoniaes, 25 parts of Camphoras, 15 parts of Calomelass,
15 parts of Radix Camelliae sinensiss, 15 parts of Borneolum Syntheticums.
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| CN102716245B (en) * | 2011-03-31 | 2014-05-28 | 丽珠医药集团股份有限公司 | Application of traditional Chinese medicine composition in preparing medicines for resisting enterovirus 71 |
| CN102423447B (en) * | 2011-11-24 | 2013-06-12 | 张成河 | Chinese medicinal composition for preventing and treating hand, foot and mouth disease in children |
| CN102552697B (en) * | 2011-12-08 | 2014-10-29 | 高海妮 | Chinese medicinal preparation for treating hand-foot-mouth disease |
| CN102499965B (en) * | 2011-12-16 | 2013-07-31 | 李秋云 | Traditional Chinese medicinal composition for fumigation for preventing hand-foot-and-mouth disease |
| CN102600361A (en) * | 2012-01-09 | 2012-07-25 | 季学君 | Powder for treating severe hand-foot-mouth disease |
| CN103007033A (en) * | 2012-12-06 | 2013-04-03 | 聂立伟 | Medicinal patch for treating hand-foot-and-mouth disease |
| CN102973754B (en) * | 2012-12-28 | 2014-08-20 | 朱天善 | Traditional Chinese medicine composition for effectively treating chalazion disease |
| CN104758317A (en) * | 2015-05-04 | 2015-07-08 | 李汶峰 | Producing method of fever abatement febrifuge |
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Non-Patent Citations (2)
| Title |
|---|
| 钱焕祥.解毒透疹汤治疗手足口病54例.《实用临床医药杂志》.2005,第9卷(第8期),74. * |
| 黄金花,等.近10年中医药防治手足口病进展.《辽宁中医药大学学报》.2010,第12卷(第2期),200-203. * |
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