CN104524287A - Traditional Chinese medicinal composition for treating anaphylactoid purpura and preparation method of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for treating anaphylactoid purpura and preparation method of traditional Chinese medicinal composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating anaphylactoid purpura. The traditional Chinese medicinal composition consists of radices stellariae dichotomae, dark plum, fruit of Chinese magnoliavine, radices lithospermi, hairyvein agrimony, lalang grass rhizome, madder, blackend swallowwort root, periostracum cicada, angelica, dandelion, schizonepeta, divaricate saposhnikovia root, coptis chinensis, scutellaria baicalensis, cape jasmine fruit, moutan bark, dried rehmannia root, radix paeoniae rubra, cornu bubali, peppermint and liquorice root. The traditional Chinese medicinal composition disclosed by the invention has functions of removing heat to cool blood, benefiting qi and promoting secretion of saliva, tonifying kidney and tranquilizing heart, and detoxifying and promoting eruption; and the traditional Chinese medicinal composition can be used for effectively treating anaphylactoid purpura.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of anaphylactoid purpura.The invention still further relates to the preparation method of this Chinese medicine composition.
Background technology
Anaphylactoid purpura is also known as schonlein-Henoch purpura or Henoch-Sch nlein syndrome.This is a kind of more common blood capillary allergic disease, and pathological changes mainly involves the capillary wall at the positions such as skin, mucosa, gastrointestinal, joint and kidney, and platelet-free reduces and blood coagulation disorders.Its permeability and fragility are increased, so that causes bleeding.There are symptom tens flecks at the beginning, being pinkish, as found stop motion at once, examination in hospital being removed, request treatment.In addition may limbs pain.If do not treated, consequence can be very serious.Some patients contact allergy is former again can recurrent exerbation.The degree of renal involvement and to lapse to be the key factor determining prognosis.Anaphylactoid purpura can betide any age, is common with child and teenager, and especially send out patient with preschool and disease in school age children many, within one-year-old, baby is rare, and male is more than women (about 1.4 ~ 2.1).
Anaphylactoid purpura shows as the symptoms such as low grade fever, pharyngalgia, upper respiratory tract infection and general malaise clinically early stage.Skin occurs maculopapule sample purpura that is symmetrical, that differ in size appears in and buttocks neighbouring based on lower limb high point joint in batches, what be mainly distributed in lower limb stretches side and buttocks, and be often symmetry, minority involves face and trunk.Purpura can give prominence to surface, accompany slight gargalesthesia, is just cerise, is kermesinus, brown then, can also shows urticaria, vasodilation, erythema multiforme, even ulcer necrosis and hemorrhagic bulla etc.
Doctor trained in Western medicine is thought, anaphylactoid purpura belongs to autoimmune disease, because body causes the permeability of blood capillary and fragility to increase to some allergin generation allergy, causes the hemorrhage and edema of subcutaneous tissue, mucosa and internal organs.Anaphylactogen can cause due to many factors, but finds its definite cause of disease to each concrete case, often has certain difficulty.It has been generally acknowledged that may be relevant with multiple risk factor, but directly paathogenic factor is normal certainly difficult.Chinese medicine is thought, primary disease is that pathogenic factor invades and harasses body, and damage venation, the excessive skin mucosa of blood circulating out of vessels forms.Its cause of disease is based on being invaded by exogenous pathogen, intemperance of taking food, stagnation of blood stasis, prolonged illness Qi and blood deficiency, and clinical is many with YANG syndrome, heat syndrome, excess syndrome, if delay endlessly, recurrent exerbation then shows as the card of deficient syndrome and simulataneous insufficiency and excessive.Anaphylactoid purpura, from the beginning of being being invaded by exogenous pathogen, being burnt caused by blood network, is very then caused dominance of heat in the interior, the absurd row of forcing blood.If with the passing of time do not heal, or recurrent exerbation, then show as deficiency of qi and blood again, stasis blocking venation, become obstinate disease.
At present, although the medicine for the treatment of this disease is more, be mostly Western medicine, although these Western medicine have certain curative effect, but its phenomenon that there is toxic and side effects is more serious, shortly can recur after drug withdrawal, patient easily produces dependency, and also having some to be medicines is hormones class medicines, life-time service hormone therapy, patient easily occurs that moon face, buffalo hump, body constitution are fat, repeatedly recurs, causes very large misery to patient.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has evident in efficacy for treatment anaphylactoid purpura, cheap, easy to use, not easily recurs, the feature had no side effect.
Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment anaphylactoid purpura.
Inventor is in clinical treatment practice for many years, observe the misery that anaphylactoid purpura is brought to child, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of anaphylactoid purpura repeatedly, the present invention selects Radix Stellariae, Fructus Mume, Fructus Schisandrae Chinensis, Radix Arnebiae (Radix Lithospermi), Herba Agrimoniae, Rhizoma Imperatae, Radix Rubiae, Radix Cynanchi Atrati, Periostracum Cicadae, Radix Angelicae Sinensis, Herba Taraxaci, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Coptidis, Radix Scutellariae, Fructus Gardeniae, Cortex Moutan, Radix Rehmanniae, Radix Paeoniae Rubra, Cornu Bubali, Herba Menthae, Radix Glycyrrhizae combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is clearing away heat and cooling blood, supplementing QI for promoting the production of body fluid, kidney calming, effect of removing toxic substances rash, thus effectively can treat anaphylactoid purpura.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Stellariae: be the dry root of Caryophyllaceae Stellaria plant Radix Stellariae Stellaria dichotoma L. var.lanceolata Bge..Nature and flavor: sweet, be slightly cold.Return liver, stomach warp.Effect: clearind deficient heat, dispelling fever with infantile malnutrition.For fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, children's's infantile malnutrition with fever.The sweet cold tonifying YIN of these product, clearing away heat and cooling blood, brings down a fever and not bitterly to let out, and the cloudy and not ascension of reason, for reducing the asthenic fever is except the common medicine of hectic fever due to YIN-deficiency, Radix Stellariae not only has the effect of heat clearing away, also has the effect of removing heat from blood concurrently.
Fructus Mume: be the dry almost ripe fruit of rose department plant plum Prunus mume (Sieh.) Sieb .et Zucc..Nature and flavor: sweet, sour, puckery, warm.Return stomach, large intestine channel.Effect: relieving diarrhea with astringents, astringing to arrest bleeding, expelling pus and promoting granulation.This product is used for not closing up for a long time after carbuncle sore is burst, and external has the effect of removing dampness expelling pus and promoting granulation." Bencao Jingshu ": Fructus Mume, namely the Fructus Mume of the present is also, the sourest." warp " is said: heat impairing vital QI, and evil visitor is in the heart, then gas superinverse and stuffy sensation with restlessness, the heart is uneasy for it.Fructus Mume sour in the mouth, can hold back superficial heat, air-breathing can return unit, therefore the main therapeutic method to keep the adverse QI flowing downwards, heat extraction stuffy sensation with restlessness and feeling at ease also.Dysentery person, large intestine collapse is also; Good saliva xerostomia person, hyperactivity of deficient fire, deficiency of body fluid is also; Acid can hold back asthenic fire, change body fluid, solid intestinal take off, so lead also.Its main limb pain, hemiplegia meciless person, covers because dampness is dipped in meridians, then muscle arteries and veins relaxes vertical, or pain is meciless; Liver governing tendons, sour in taste acting on the liver and nourishing muscle and tendon, liver obtain support, then solid skeleton and pliable tendons, machine-operated tonneau and front card removes.
Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or schisandra chinensis Schisandra sphenanthera Rehd. et Wils..Nature and flavor: warm, sour, sweet.Return lung, the heart, kidney channel.Function: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Radix Arnebiae (Radix Lithospermi): be the root of comfrey Radix Arnebiae (Radix Lithospermi) (gromwell root) (Lithosper-mum erythorhizon sieb. et zucc.) and lithospermum euchromum Royle (Radix Arnebiae) [Arnebia euchroma(Royle) Johnst.].Nature and flavor: cold, sweet, salty.Gui Jing: GUIXIN, Liver Channel.Function: removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention.
Herba Agrimoniae: be the aerial parts of Rosaceae herbaceos perennial Agrimony Agrimonia pilosa Ledeb..Nature and flavor: bitter, puckery, flat.GUIXIN, Liver Channel.Effect: astringing to arrest bleeding, removing toxic substances, dysentery relieving, parasite killing cuts cruel.For hemoptysis, spit blood, control epistaxis and have specially good effect, malaria, de-power impairment caused by overstrain, carbuncle.This product puckery convergence and property is put down, no matter the going out blood disorder and all can apply of cold and heat and asthenia and sthenia.The symptoms such as treatment heat in blood is hemorrhage.
Rhizoma Imperatae: be the rhizome of grass perennial herb Herba Imperatae Imperata cylindrica.Nature and flavor: sweet, cold.Return lung, stomach, urinary bladder channel.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria, " Bencao Jingshu " is recorded: impairment caused by overstrain void is won, must interior-heat, and Rhizoma Imperatae is sweet can spleen reinforcing, sweet, though cold and do not violate stomach.Gan Hanneng is except interior-heat, therefore main impairment caused by overstrain void is won.Strengthening the spleen so invigorating middle warmer, heat extraction so QI invigorating, the beneficial blood of sweet energy, heat in blood is the stasis of blood then, and the stasis of blood is then closed, and closes then cold and heat and does, cold and cool blood, sweet beneficial blood, heat go then blood and, and then stagnation resolvation and close logical, general rule cold and heat are from only also.
Radix Rubiae: be the dry root and rhizome of Maguireothamnus speciosus Radix Rubiae Rubia cordifolia L..Nature and flavor: bitter, cold.Return Liver Channel.Effect: removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow.For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.Clinical practice: for the multiple hemorrhage card of bleeding due to blood-heat.Radix Rubiae cold in nature enter blood system, can cooling blood for hemostasis, and can blood stasis dispelling.The going out blood disorder and all can select of all bleeding due to blood-heaies, the stasis of blood person that holds concurrently is especially suitable.
Radix Cynanchi Atrati: be asclepiadaceae plant Radix Cynanchi Atrati Cynanchum atratum Bge.Or Cynanchum versicolor Bunge Cynanchum versicolor Bge.Dry root and rhizome.Nature and flavor: bitter, salty, cold.Return stomach, liver, kidney channel.Effect: clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment.For pathogenic warmth wound battalion heating, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, puerperal fever due to deficiency of blood, pyretic stranguria, stranguria with blood, swollen ulcer drug.This product bitter cold, be apt to, into blood system, have clearing away heat and cooling blood, the merit of tonifying YIN heat extraction, can excess-heat clearly, again can reducing the asthenic fever, be used for the treatment of warm febrile disease and join the army blood, high hot excessive thirst, coma crimson tongue.
Periostracum Cicadae: exuviae shell when the larva for cicada Cryptotympana atrata Fabr. Cryptotympana pustulata Fabricius sprouts wings.Nature and flavor: sweet, cold.Return lung, Liver Channel.Effect: dispelling wind and heat pathogens, rash are antipruritic, improving acuity of vision and removing nebula, endogenous wind stopping relieving convulsion.This product a surname is loose to be sent out thoroughly, wind-dispelling heat-dissipating, and rash antipruritic can be used for treats measles, eczema etc.For affection due to external wind and heat, fever with chills, cough, and the disease such as rubella, skin pruritus.Periostracum Cicadae has dispelling wind and heat pathogens effect, often coordinates the equivalent use of Herba Menthae for wind heat table disease; Rubella pruritus is also had to the function of dispelling wind for relieving itching.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.For blood deficiency and yellow complexion, dizzy cardiopalmus, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores.Carry according to " book on Chinese herbal medicine is just ": " its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, nothing unsuitable." modern medicine study confirmation, Radix Angelicae Sinensis has antibacterial, antiinflammation, and the pain relieving of Radix Angelicae Sinensis energy promoting blood circulation and detumescence, again can tonic blood and growing muscle.
Herba Taraxaci: Herba Taraxaci, also known as bed-wetting grass, is feverfew Herba Taraxaci Toraxacum mongolicum Hand. Mazz., alkali ground Herba Taraxaci Toraxacum borealisinense Kitam. or the dry herb belonging to several plants together.Nature and flavor: sweet, micro-hardship, cold.Return liver, stomach warp.Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Herba Taraxaci has effect of antiinflammatory, antibacterial, antitumor, heat-clearing and toxic substances removing, and applied range on modern clinic, makes good use of.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Acute mastitis caused by pyretic toxicity is swollen and ache, furuncle has good effect, juice can be decocted separately and take orally, or external application local; Also other heat and toxic materials clearing away medicine can be coordinated with using.
Herba Schizonepetae: be the dry aerial parts of labiate Herba Schizonepetae Schizonepeta tenuifolia Briq..Nature and flavor: pungent, bitter, micro-wet.Return lung, Liver Channel.Effect: dispel the wind; Induce sweat; Rash; Hemostasis.Main cold, fever; Headache; Eye itching; Cough; Laryngopharynx swelling and pain; Measles; Carbuncle; Skin ulcer scabies; Epistaxis; Spit blood; Have blood in stool; Metrorrhagia; Puerperal blood faints.This product Chhnang is loose thoroughly, can dispelling wind for relieving itching, and the loose measles toxin of a surname, can be used for measles without adequate eruption, rubella pruritus, in addition Herba Schizonepetae also can be used for skin infection from the beginning of, relatively wind heat this, compatibility Flos Loniceraes etc., Herba Schizonepetae and Radix Saposhnikoviae mutual reinforcement between are use, strengthen expelling pathogenic wind from the body surface effect.
Radix Saposhnikoviae: be the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk..Nature and flavor: pungent, sweet, tepor.Return bladder, lung, spleen, Liver Channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.For diseases caused by exogenous pathogenic factor exterior syndrome or rubella pruritus.This product slightly warm in nature and not dry, sweet slow and not high, there is the title of " the profit agent in wind medicine ", no matter wind and cold, wind heat exterior syndrome all can be applied.This product also can be used for tetanus, gnathospasma, opisthotonus.Radix Saposhnikoviae controls tetanus, has the effect of expellingging wind and relieving convulsion.
Rhizoma Coptidis: be the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C. Y. Cheng et Hsiao or Coptis Teeta Wall Coptis teeta Wall..Nature and flavor: bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.Antibacterial action: staphylococcus aureus, Hemolytic streptococcus, streptococcus pneumoniae, meningococcus, dysentery bacterium, anthrax bacillus etc.Detoxication: antagonism bacteriotoxin, reduction staphylococcus aureus coagulase, hemolysin are tired, and reduce colibacillary virulence.
Radix Scutellariae: be the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Nature and flavor: bitter, cold.Return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.The clinical practice of Radix Scutellariae is antibacterial relatively good, and does not develop immunity to drugs.This product has the merit of clearing away heat and cooling blood hemostasis, intimately flourishing with controlling, the haematemesis of the absurd row of forcing blood, and metrorrhagia, has blood in stool, and normal being equal to Rhizoma Imperatae is used.
Fructus Gardeniae: be the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis.Nature and flavor: bitter, cold.GUIXIN, lung, tri-jiao channel.Effect: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.The haematemesis caused for pyretic toxicity, excess-fire, epistaxis, hematuria, the disease such as conjunctival congestion and swelling pain and sore swollen toxin.Fructus Gardeniae has again the effect of cooling blood for hemostasis, heat-clearing and toxic substances removing, with controlling bleeding due to blood-heat, and the compatibilities such as normal and the Radix Rehmanniae, Cacumen Platycladi, Cortex Moutan.
Cortex Moutan: be the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor are bitter, cool.GUIXIN, liver, kidney, lung meridian.Effect: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.The power of Cortex Moutan removing heat from blood is stronger, can be purified the blood a point excess-heat, can control fever due to yin deficiency again, this product cold nature, energy clearing heat in YING system divides, blood system excess-heat, have the merit of cooling blood for hemostasis, and Cortex Moutan is pungent cold, is apt to into blood system, can removing heat from blood with hemostasis, can invigorate blood circulation with dissipating blood stasis again, the kind logical heat in blood stasis of blood is stagnant, and normal and Radix Rehmanniae, Radix Paeoniae Rubra are used together.
Radix Rehmanniae: be the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Nature and flavor: sweet, cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Can be used for Tianjin wound thirsty, interior-heat is quenched one's thirst.This product is sweet cold, can among heat clearing away YIN nourishing and the production of body fluid promoting, cold in nature and enter blood system, can not only the heat of clearing heat in YING system blood system and removing heat from blood, and sweet in the mouth is cold in nature can promote the production of body fluid, there is the effect of nourishing YIN and clearing away heat, be used for the treatment of heat in blood and tell nosebleed, metrorrhagia of having blood in stool, epidemic febrile disease heat enters nutrient blood, normal and Cortex Moutan, and Radix Paeoniae Rubra is with using.
Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.Nature and flavor are bitter, are slightly cold.Return Liver Channel.Effect: eliminating stasis to stop pain, clearing away heat and cooling blood, detumescence.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.This product hardship is fallen, and has effect of promoting blood circulation to restore menstrual flow, loose Yu Xiao wei, row stagnation pain.Often join Cortex Moutan.For the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, this product bitter cold, main enter Liver Channel, be apt to away blood system, can clearing away liver-fire, except blood system is hot and suffocating and have the merit of removing heat from blood, hemostasis, dissipating blood stasis speckle removing.
Cornu Bubali: be the angle of bovid Babalus bubalis L. Bubalus bubalis Linnaeus.Nature and flavor: bitter, cold.GUIXIN, Liver Channel.Effect: heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.For the high heat of epidemic febrile disease, unconsciousness and delirium, sends out speckle dermexanthesis, hematemesis and epistaxis, infantile convulsion, demented.
Herba Menthae: be the aerial parts of Labiatae (Labiatae) perennial root herbaceous plant Mentha (Mentha).Nature and flavor: pungent, cool.Return lung, Liver Channel.Effect: wind-dispelling heat-dissipating, refresh oneself, throat, rash poison, dispersing the stagnated live-QI to relieve the stagnation of QI.The circulation of qi promoting of this product acrid in the mouth, can enter Liver Channel again, therefore energy dispersing the stagnated live-QI to relieve the stagnation of QI, Chang Peiwu Radix Bupleuri, Radix Angelicae Sinensis.Bactericidal action: Mentholum has very strong bactericidal action, d-Mentholum is stronger than the bacteriostasis of 1-Mentholum.These product lightly float and rise floating, awakening consciousness, and merit is kind evacuates part of the body cavity above the diaphragm housing the heart and lungs wind heat, refresh oneself, throat.
Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor are sweet, flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.
Side's solution of the present invention is: Radix Stellariae clearind deficient heat, dispelling fever with infantile malnutrition in side, Fructus Mume astringing to arrest bleeding, expelling pus and promoting granulation, Fructus Schisandrae Chinensis supplementing QI for promoting the production of body fluid, kidney calming, Radix Arnebiae (Radix Lithospermi) removing heat from blood and promoting blood circulation, removing toxic substances rash, Herba Agrimoniae astringing to arrest bleeding, the above five tastes are monarch drug altogether, because anaphylactoid purpura is a kind of hematologic disease, many because of bleeding due to blood-heat, forcing blood is excessive to be caused in passages through which vital energy circulates, and monarch drug fundamentally carries out clearing away heat and cooling blood to the health of patient first from disease, control the appearance of speckle, and there is the effect of removing toxic substances rash, prevent exopathogen to be detained in body, cause and again occur.Rhizoma Imperatae, Radix Rubiae cooling blood for hemostasis, Radix Cynanchi Atrati clearing away heat and cooling blood, Periostracum Cicadae dispelling wind and heat pathogens, rash are antipruritic, and Chinese angelica blood supplementing is invigorated blood circulation, Herba Taraxaci heat-clearing and toxic substances removing, above Six-element is ministerial drug altogether, not only can increase the effect of monarch drug clearing away heat and cooling blood, removing toxic substances rash, and carry out enriching blood invigorating blood circulation, kidney calming, reinforcement inner blood circulates, and reduces the phenomenon causing purpura that blood is excessive.Herba Schizonepetae, anti-wind, relieving exterior syndrome rash, Rhizoma Coptidis, Radix Scutellariae heat clearing and damp drying, Fructus Gardeniae pathogenic fire purging relieving restlessness; Cortex Moutan, Radix Rehmanniae clearing away heat and cooling blood, Radix Paeoniae Rubra coordinates Cortex Moutan, Radix Rehmanniae eliminating stasis to stop pain, Cornu Bubali heat-clearing and toxic substances removing; Herba Menthae wind-dispelling heat-dissipating, above a few taste is adjuvant drug altogether, the health of conditioning patient; avoid medicine to bring secondary injury to child, child protection does not have full grown internal organs, accelerates the rehabilitation of patient simultaneously yet; Radix Glycyrrhizae spleen reinforcing stomach function regulating; coordinating the actions of various ingredients in a prescription, priming return through, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has clearing away heat and cooling blood, supplementing QI for promoting the production of body fluid, kidney calming, and effect of removing toxic substances rash, effectively can treat anaphylactoid purpura.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Stellariae 5-15 part, Fructus Mume 10-20 part, Fructus Schisandrae Chinensis 4-14 part, Radix Arnebiae (Radix Lithospermi) 7-17 part, Herba Agrimoniae 13-23 part, Rhizoma Imperatae 13-23 part, Radix Rubiae 7-17 part, Radix Cynanchi Atrati 7-17 part, Periostracum Cicadae 3-9 part, Radix Angelicae Sinensis 7-17 part, Herba Taraxaci 10-20 part, Herba Schizonepetae 4-14 part, Radix Saposhnikoviae 3-9 part, Rhizoma Coptidis 1-5 part, Radix Scutellariae 3-9 part, Fructus Gardeniae 1-5 part, Cortex Moutan 3-9 part, Radix Rehmanniae 4-14 part, Radix Paeoniae Rubra 3-9 part, Cornu Bubali 3-9 part, Herba Menthae 1-5 part, Radix Glycyrrhizae 1-5 part.
Wherein be preferably: Radix Stellariae 10 parts, Fructus Mume 15 parts, Fructus Schisandrae Chinensis 9 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, Herba Agrimoniae 18 parts, Rhizoma Imperatae 18 parts, 12 parts, Radix Rubiae, Radix Cynanchi Atrati 12 parts, Periostracum Cicadae 6 parts, Radix Angelicae Sinensis 12 parts, Herba Taraxaci 15 parts, Herba Schizonepetae 9 parts, Radix Saposhnikoviae 6 parts, Rhizoma Coptidis 3 parts, Radix Scutellariae 6 parts, Fructus Gardeniae 3 parts, Cortex Moutan 6 parts, Radix Rehmanniae 9 parts, Radix Paeoniae Rubra 6 parts, Cornu Bubali 6 parts, Herba Menthae 3 parts, Radix Glycyrrhizae 3 parts.
A kind of preparation method for the treatment of the Chinese medicine preparation of anaphylactoid purpura is as follows:
Step one: by weight proportion of the present invention, first becomes medicated bag by Fructus Mume, Fructus Schisandrae Chinensis, Fructus Gardeniae bundle, is put in water and soaks about 45 minutes, filters, for subsequent use;
Step 2: by weight proportion of the present invention, by Radix Stellariae, Radix Arnebiae (Radix Lithospermi), Rhizoma Imperatae, Radix Rubiae, Radix Cynanchi Atrati, Radix Angelicae Sinensis, Radix Saposhnikoviae, Rhizoma Coptidis, Radix Scutellariae, Cortex Moutan, Radix Rehmanniae, Radix Paeoniae Rubra is put into after marmite adds step one immersion and is remained cold water, exceed powder 2 ~ 5 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 3 cm is added in residue medicinal residues, then Herba Agrimoniae is added, Herba Taraxaci, Herba Schizonepetae, medicated bag in Herba Menthae and step one decocts about 30 minutes, add Radix Glycyrrhizae afterwards and decoct filtration in 20 minutes, obtain filtrate, merge twice filtrate, filter, waste, for subsequent use,
Step 3: by weight proportion of the present invention, grinds into powder be crushed to 200 mesh sieves by Periostracum Cicadae, Cornu Bubali, for subsequent use;
Step 4: by the powder Homogeneous phase mixing in step 3 in step 2, and gained medicinal liquid is carried out concentration operation, add xylitol to cook flavoring agent, benzoic acid 0.25% and nipalgin 0.05% and cook antiseptic do mixing, total amount is adjusted to distilled water or ionized water, put into the cool heavy 24-48 hour of icebox, filter, fill, flowing steam sterilization, obtains the oral liquid for the treatment of anaphylactoid purpura of the present invention.
Medicine of the present invention has clearing away heat and cooling blood, supplementing QI for promoting the production of body fluid, kidney calming, the effects such as removing toxic substances rash, and it is evident in efficacy, cheap, easy to use, not easily recur, have no side effect, the mode that this Chinese medicine preparation adopts is treated and can be reduced the damage of Western medicine to child's hepatic and renal function, and the improvement accelerating the state of an illness is added up according to clinical 210 routine patient view, medicine of the present invention is used to take medicine total effective rate 91%, two course for the treatment of total effective rate course for the treatment of 98.1%.
Detailed description of the invention
Embodiment one, Radix Stellariae 5 parts, Fructus Mume 10 parts, Fructus Schisandrae Chinensis 4 parts, Radix Arnebiae (Radix Lithospermi) 7 parts, Herba Agrimoniae 13 parts, Rhizoma Imperatae 13 parts, 7 parts, Radix Rubiae, Radix Cynanchi Atrati 7 parts, Periostracum Cicadae 3 parts, Radix Angelicae Sinensis 7 parts, Herba Taraxaci 10 parts, Herba Schizonepetae 4 parts, Radix Saposhnikoviae 3 parts, Rhizoma Coptidis 1 part, Radix Scutellariae 3 parts, Fructus Gardeniae 1 part, Cortex Moutan 3 parts, Radix Rehmanniae 4 parts, Radix Paeoniae Rubra 3 parts, Cornu Bubali 3 parts, Herba Menthae 1 part, Radix Glycyrrhizae 1 part.
Embodiment two, Radix Stellariae 10 parts, Fructus Mume 15 parts, Fructus Schisandrae Chinensis 9 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, Herba Agrimoniae 18 parts, Rhizoma Imperatae 18 parts, 12 parts, Radix Rubiae, Radix Cynanchi Atrati 12 parts, Periostracum Cicadae 6 parts, Radix Angelicae Sinensis 12 parts, Herba Taraxaci 15 parts, Herba Schizonepetae 9 parts, Radix Saposhnikoviae 6 parts, Rhizoma Coptidis 3 parts, Radix Scutellariae 6 parts, Fructus Gardeniae 3 parts, Cortex Moutan 6 parts, Radix Rehmanniae 9 parts, Radix Paeoniae Rubra 6 parts, Cornu Bubali 6 parts, Herba Menthae 3 parts, Radix Glycyrrhizae 3 parts.
Embodiment three, Radix Stellariae 15 parts, Fructus Mume 20 parts, Fructus Schisandrae Chinensis 14 parts, Radix Arnebiae (Radix Lithospermi) 17 parts, Herba Agrimoniae 23 parts, Rhizoma Imperatae 23 parts, 17 parts, Radix Rubiae, Radix Cynanchi Atrati 17 parts, Periostracum Cicadae 9 parts, Radix Angelicae Sinensis 17 parts, Herba Taraxaci 20 parts, Herba Schizonepetae 14 parts, Radix Saposhnikoviae 9 parts, Rhizoma Coptidis 5 parts, Radix Scutellariae 9 parts, Fructus Gardeniae 5 parts, Cortex Moutan 9 parts, Radix Rehmanniae 14 parts, Radix Paeoniae Rubra 9 parts, Cornu Bubali 9 parts, Herba Menthae 5 parts, Radix Glycyrrhizae 5 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Accept out-patient 420 example for medical treatment.Patient is divided into observation group and matched group at random, wherein male 252 example, women 168 example, M-F 1.5:1, max age 23 years old, minimal ages 3 years old, every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).
Two, Therapeutic Method
1, observation group is according to Medications Example two of the present invention, and oral liquid prepared by preferred preparation method, and every day 3 times, each one 7 days is a course for the treatment of.
2, matched group is according to the Chinese medicine composition decoction for the treatment of anaphylactoid purpura in CN 103083570 A, patient's morning and evening service once every day, within 7 days, is an observation period.
Three, efficacy assessment standard
1, cure: the Clinical symptom and sign such as subcutaneous plaque-like and little petechial hemorrhage, purpura and ecchymosis disappear, functional activity recovers normal, and every Index for examination is normal.
2, take a turn for the better: the basic or partial disappearance of subcutaneous plaque-like and little petechial hemorrhage, purpura and ecchymosis Clinical symptom and sign, every Index for examination major part is normal.
3, do not heal: Clinical symptom and sign is without improvement, and subcutaneous hemorrhage, purpura and ecchymosis have no disappearance, and every Index for examination is still abnormal.
Four, observation group's result statistics
Matched group result is added up
Wherein: total effective rate=cure rate+improvement rate
Take the Comparison of therapeutic situation of two groups of patients, two courses for the treatment of
Can find that observation group is apparently higher than matched group, illustrates thus by the treatment total effective rate contrasting two groups of patients, Chinese medicine of the present invention has good clinical effectiveness in treatment anaphylactoid purpura, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.
Model case and curative effect:
Case one, Guo, female, 10 years old, suddenly tormina, finds two lower limb large area purpura on inspection, removes examination in hospital, platelet count is normal, it is colour-fast that purpura is pressed, and is diagnosed as anaphylactoid purpura, upon somebody's introduction, come here to go to a doctor, adopt case two method of the present invention, after taking a course for the treatment of, purpura obviously alleviates patient of hypersensitivity's property; extent of disease obviously reduces; for preventing recurrence, continue to take a course for the treatment of, patient purpura phenomenon all disappears; go to hospital to check; indices is completely normal, follows up a case by regular visits to and has no recurrence half a year, recovery from illness.
Case two, field, man, 13 years old, lusterless complexion, hair dries up, and diet is not good enough, with the symptom such as dizzy, nose is bled, the purpura that two lower limb are symmetrical as seen, removes examination in hospital, be diagnosed as anaphylactoid purpura, patient wishes to adopt Chinese traditional treatment, comes here and goes to a doctor, adopt case two method of the present invention, after taking a course for the treatment of, anaphylactoid purpura alleviates, and scope reduces gradually, for preventing recurrence, continue to take two courses for the treatment of, patient clinical symptom disappears completely, goes to hospital to check, indices is all normal, follow up a case by regular visits to half a year, have no recurrence, recovery from illness.
Claims (4)
1. treat the Chinese medicine composition of anaphylactoid purpura for one kind, it is characterized in that, this Chinese medicine composition is made up of the medicine of following weight portion: Radix Stellariae 5-15 part, Fructus Mume 10-20 part, Fructus Schisandrae Chinensis 4-14 part, Radix Arnebiae (Radix Lithospermi) 7-17 part, Herba Agrimoniae 13-23 part, Rhizoma Imperatae 13-23 part, Radix Rubiae 7-17 part, Radix Cynanchi Atrati 7-17 part, Periostracum Cicadae 3-9 part, Radix Angelicae Sinensis 7-17 part, Herba Taraxaci 10-20 part, Herba Schizonepetae 4-14 part, Radix Saposhnikoviae 3-9 part, Rhizoma Coptidis 1-5 part, Radix Scutellariae 3-9 part, Fructus Gardeniae 1-5 part, Cortex Moutan 3-9 part, Radix Rehmanniae 4-14 part, Radix Paeoniae Rubra 3-9 part, Cornu Bubali 3-9 part, Herba Menthae 1-5 part, Radix Glycyrrhizae 1-5 part.
2. the Chinese medicine composition of the treatment anaphylactoid purpura according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Stellariae 10 parts, Fructus Mume 15 parts, Fructus Schisandrae Chinensis 9 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, Herba Agrimoniae 18 parts, Rhizoma Imperatae 18 parts, 12 parts, Radix Rubiae, Radix Cynanchi Atrati 12 parts, Periostracum Cicadae 6 parts, Radix Angelicae Sinensis 12 parts, Herba Taraxaci 15 parts, Herba Schizonepetae 9 parts, Radix Saposhnikoviae 6 parts, Rhizoma Coptidis 3 parts, Radix Scutellariae 6 parts, Fructus Gardeniae 3 parts, Cortex Moutan 6 parts, Radix Rehmanniae 9 parts, Radix Paeoniae Rubra 6 parts, Cornu Bubali 6 parts, Herba Menthae 3 parts, Radix Glycyrrhizae 3 parts.
3. the Chinese medicine preparation for the treatment of anaphylactoid purpura according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is oral liquid.
4. treat a preparation method for the Chinese medicine preparation of anaphylactoid purpura, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, first Fructus Mume, Fructus Schisandrae Chinensis, Fructus Gardeniae bundle are become medicated bag, be put in water and soak about 45 minutes, filter, for subsequent use, step 2: by weight proportion of the present invention, by Radix Stellariae, Radix Arnebiae (Radix Lithospermi), Rhizoma Imperatae, Radix Rubiae, Radix Cynanchi Atrati, Radix Angelicae Sinensis, Radix Saposhnikoviae, Rhizoma Coptidis, Radix Scutellariae, Cortex Moutan, Radix Rehmanniae, Radix Paeoniae Rubra is put into after marmite adds step one immersion and is remained cold water, exceed powder 2 ~ 5 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 3 cm is added in residue medicinal residues, then Herba Agrimoniae is added, Herba Taraxaci, Herba Schizonepetae, medicated bag in Herba Menthae and step one decocts about 30 minutes, add Radix Glycyrrhizae afterwards and decoct filtration in 20 minutes, obtain filtrate, merge twice filtrate, filter, waste, for subsequent use, step 3: by weight proportion of the present invention, grinds into powder be crushed to 200 mesh sieves by Periostracum Cicadae, Cornu Bubali, for subsequent use, step 4: by the powder Homogeneous phase mixing in step 3 in step 2, and gained medicinal liquid is carried out concentration operation, add xylitol to cook flavoring agent, benzoic acid 0.25% and nipalgin 0.05% and cook antiseptic do mixing, total amount is adjusted to distilled water or ionized water, put into the cool heavy 24-48 hour of icebox, filter, fill, flowing steam sterilization, obtains the oral liquid for the treatment of anaphylactoid purpura of the present invention.
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Cited By (6)
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|---|---|---|---|---|
| CN104825905A (en) * | 2015-06-03 | 2015-08-12 | 于晓红 | Traditional Chinese medicine preparation for treating blood transfusion reaction and method for manufacturing traditional Chinese medicine preparation |
| CN104984030A (en) * | 2015-06-29 | 2015-10-21 | 孙霞 | Traditional Chinese medicine for treating children's purpura |
| CN107551201A (en) * | 2017-10-26 | 2018-01-09 | 刘萍 | A kind of medicine for treating anaphylactoid purpura and preparation method thereof |
| CN108201611A (en) * | 2016-12-17 | 2018-06-26 | 景金发 | Anaphylactoid purpura preparation |
| CN114099585A (en) * | 2022-01-11 | 2022-03-01 | 河南中医药大学 | Traditional Chinese medicine composition for treating anaphylactoid purpura as well as preparation method and application thereof |
| CN117582476A (en) * | 2023-11-22 | 2024-02-23 | 沧州市中心医院 | An easy-to-take traditional Chinese medicine preparation for allergic purpura |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825905A (en) * | 2015-06-03 | 2015-08-12 | 于晓红 | Traditional Chinese medicine preparation for treating blood transfusion reaction and method for manufacturing traditional Chinese medicine preparation |
| CN104984030A (en) * | 2015-06-29 | 2015-10-21 | 孙霞 | Traditional Chinese medicine for treating children's purpura |
| CN108201611A (en) * | 2016-12-17 | 2018-06-26 | 景金发 | Anaphylactoid purpura preparation |
| CN107551201A (en) * | 2017-10-26 | 2018-01-09 | 刘萍 | A kind of medicine for treating anaphylactoid purpura and preparation method thereof |
| CN114099585A (en) * | 2022-01-11 | 2022-03-01 | 河南中医药大学 | Traditional Chinese medicine composition for treating anaphylactoid purpura as well as preparation method and application thereof |
| CN114099585B (en) * | 2022-01-11 | 2024-05-03 | 河南中医药大学 | Traditional Chinese medicine composition for treating allergic purpura and preparation method and application thereof |
| CN117582476A (en) * | 2023-11-22 | 2024-02-23 | 沧州市中心医院 | An easy-to-take traditional Chinese medicine preparation for allergic purpura |
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