CN104758711A - Chinese herba preparation for treating pulmonary sarcoidosis and preparing method thereof - Google Patents

Abstract

The invention discloses a Chinese herba preparation for treating the pulmonary sarcoidosis. The Chinese herba preparation is made of sealwort, astragalus membranaceus, radices stellariae dichotomae, rhizoma phragmitis, kudzuvine roots, lalang grass rhizome, oriental wormwood, cortex lycii radicis, radix glehniae, rhizoma anemarrhenae, radix ophiopogonis, dendrobium nobile, red-rooted salvia roots, red flowers, tangerines, ligusticum wallichii, honeysquckle, dandelions, scutellaria baicalensis, codonopsis pilosula, fried atractylodes macrocephala Koidz, poria cocos, dried rehmannia roots and honey-fried licorice roots according to a certain weight ratio. The Chinese herba preparation has the effects of tonifying qi, nourishing yin, tonifying the spleens, moistening the lungs and removing heat to promote salivation, and the pulmonary sarcoidosis can be effectively treated.

Description

A kind of Chinese medicine preparation for the treatment of pulmonary sarcoidosis and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of pulmonary sarcoidosis, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Pulmonary sarcoidosis was once called as sarcoid, was agnogenic allergic disease.Pathological change is non-thousand cheese granulomas, can invade each organ of whole body, but more involves lymph node, lung, liver, spleen and skin etc., is generally distributed in the whole world and agnogenic multisystem granulomatous diseases.Primary disease is apt to occur in 10-40 year, and 20-30 year reaches peak.Women is more than male.

The main clinical manifestation of pulmonary sarcoidosis is intrathoracic sarcoidosis, and hilus pulumonis, mediastinal lymph nodes and pulmonary parenchyma are got involved and the most commonly accounted for more than 90%, therefore rabat finds intrathoracic sarcoid Main Means.Intrathoracic sarcoidosis, based on respiratory symptom, shows as cough, expectoration, uncomfortable in chest, expectorant blood, pneumothorax, hydrothorax etc.Sarcoidosis is the result that unknown antigen and Cellular Immunity and humoral immune function contend with mutually.Due to the difference (age, sex, race, inherited genetic factors, hormone, HLA) of individuality and the regulating action of antibody mediated immunity reaction, imbalance state between the promotive factor produced depending on it and antagonizes factor, and determine granulomatous development and disappear, show the trend of the different pathological state of sarcoidosis and natural remission.

Mostly the medicine of current this disease for the treatment of is symptomatic treatment, mainly glucocorticoid medicine, but hormone medicine easily makes patient body produce dependency, and easily causes the hormone in vivo of patient to lack of proper care, and brings irreversible injury to patient, Chinese traditional treatment disease is many fundamentally starts with from treatment, can't disease be treated the head when the head aches, foot pain cures foot, but treatment must aim at the pathogenesis of disease, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, nurse one's health from body interior and carry out treating, alleviate the misery of extensive patients.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of pulmonary sarcoidosis, this Chinese medicine preparation has determined curative effect for pulmonary sarcoidosis, cheap, safe ready, the feature that side effect is little.

Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment pulmonary sarcoidosis.

Inventor is in clinical treatment practice for many years, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of pulmonary sarcoidosis repeatedly, the present invention selects Rhizoma Polygonati, the Radix Astragali, Radix Stellariae, Rhizoma Phragmitis, Radix Puerariae, Rhizoma Imperatae, Herba Artemisiae Scopariae, Cortex Lycii, Radix Glehniae, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Herba Dendrobii, Radix Salviae Miltiorrhizae, Flos Carthami, Fructus Citri tangerinae is red, Rhizoma Chuanxiong, Flos Lonicerae, Herba Taraxaci, Radix Scutellariae, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Poria, Radix Rehmanniae, Radix Glycyrrhizae Preparata combines, by these drug regimens, each efficacy of drugs is made to produce synergism, make it that there is boosting qi and nourishing yin, spleen invigorating lung moistening, effect of clearing away heat and promoting production of body fluid, thus effectively can treat pulmonary sarcoidosis.

The effect of Chinese medicine of the present invention:

Wherein:

Rhizoma Polygonati: be the dry rhizome of liliaceous plant P. kingianum Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor: sweet are flat.Return spleen, lung, kidney channel.Effect: boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst." book on Chinese herbal medicine is just read ": Rhizoma Polygonati, for growing greasy product, clothes of a specified duration make us not hungry, have wet person if insufficiency of the spleen, should not take it, and probably its greasy diaphragm also.These flavour of a drug are sweet as maltosemalt sugar, and the flat matter profit of property is the certified products of tonic spleen the moon.

The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.Effect: tonifying Qi and lifting yang, consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.This product all has inhibitory action to dysentery bacterium, anthrax bacillus, α-hemolytic streptococcus, beta hemolytic streptococcus, diphtheria corynebacterium, bacillus pseudodiphthericus, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, bacillus subtilis etc. in vitro.Invigorating the spleen and replenishing QI is good at by the Radix Astragali, is the key medicine of tonifying Qi and lifting yang, and QI invigorating diuresis, to subside a swelling.

Radix Stellariae: be the dry root of Caryophyllaceae Stellaria plant Radix Stellariae Stellaria dichotoma L. var.lanceolata Bge..Nature and flavor: sweet, be slightly cold.Return liver, stomach warp.Effect: clearind deficient heat, dispelling fever with infantile malnutrition.For fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, children's's infantile malnutrition with fever.The sweet cold tonifying YIN of these product, clearing away heat and cooling blood, brings down a fever and not bitterly to let out, and the cloudy and not ascension of reason, for reducing the asthenic fever is except the common medicine of hectic fever due to YIN-deficiency, Radix Stellariae not only has the effect of heat clearing away, also has the effect of removing heat from blood concurrently.

Rhizoma Phragmitis: be the fresh or dry rhizome of grass phragmites communis Phragmites communis Trin..Nature and flavor: sweet, cold.Return lung meridian, stomach warp.Function: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Rhizoma Phragmitis can clearing away lung-heat and evacuation of pus of eliminating the phlegm, again can clearing away stomach-heat and the preventing or arresting vomiting that promotes the production of body fluid.Though its attribute is trembled with fear, slightly sweet flavor and power use lung heat clearing stomach, can only as auxiliary medicine.But, it has an advantage, and namely property is not grown greasy, promotes the production of body fluid and does not love heresy, and all epidemic febrile disease deep loves are defended, gas, or if any the syndrome that impairment of body fluid is thirsty after calentura, all can apply.

Radix Puerariae: be the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.Nature and flavor: cool, sweet, pungent.Enter spleen, stomach warp.Effect: induce sweat and bring down a fever, promotes the production of body fluid, rash, yang invigorating antidiarrheal.Radix Puerariae is sweet pungent cool in nature, and lightly floating, it is loose to rise, and enters taste warp, has relieving the exterior syndrome by diaphoresis, the merit of expelling pathogenic factors from muscles for reducing heat.This product performance sending up the lucid YANG, inspire taste yang-energy to rise, have the effect prevented and have loose bowels, clinical normal cooperation Radix Codonopsis, Bai Intraoperative etc. treat diarrhea due to hypofunction of the spleen; But can Rhizoma Coptidis, Radix Scutellariae etc. be joined, for diseases such as damp-heat dysenteries.

Rhizoma Imperatae: be the rhizome of grass perennial herb Herba Imperatae Imperata cylindrica.Nature and flavor: sweet, cold.Return lung, stomach, urinary bladder channel.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria, " Bencao Jingshu " is recorded: impairment caused by overstrain void is won, must interior-heat, and Rhizoma Imperatae is sweet can spleen reinforcing, sweet, though cold and do not violate stomach.Gan Hanneng is except interior-heat, therefore main impairment caused by overstrain void is won.Strengthening the spleen so invigorating middle warmer, heat extraction so QI invigorating, the beneficial blood of sweet energy, heat in blood is the stasis of blood then, and the stasis of blood is then closed, and closes then cold and heat and does, cold and cool blood, sweet beneficial blood, heat go then blood and, and then stagnation resolvation and close logical, general rule cold and heat are from only also.Dysuria, due to interior-heat also, pyrolysis then just diarrhea.Pouring person, caused by blood system deficiency-heat also, removing heat from blood benefit blood, then drench spontaneous recovery, and the exopathogenic heat of the intestines and stomach is explained by oneself, and body fluid is raw and yearningly also stop.Blood stored in the liver and main muscle, cool liver of enriching blood, then muscle is hard.Heat in blood then collapses, and removing heat from blood and blood, then collapse spontaneous recovery.Heat in blood is absurd row then, overflow upper orifices for telling, for coughing up, be epistaxis, bleeding from the gum, removing heat from blood and blood, then all cards are from removing.Strengthening the spleen invigorating middle warmer, diuresis, therefore swollen jaundice of also harnessing the river, and hold concurrently reason typhoid fever hiccup also.

Herba Artemisiae Scopariae: be the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparia Waldst. et Kit. or Herba Artemisiae Scopariae Artemisia capillaris Thunb..Nature and flavor: bitter, pungent, are slightly cold.Return spleen, stomach, liver, gallbladder meridian.Effect: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis.The effect of this product jaundice eliminating subcutaneous ulcer is excellent, therefore except for except jaundice due to damp-heat, for the YIN jaundice disease because occurring by cold-damp or innate deficiency of YANG in the body, also can apply.But the product use as same in the medicine such as Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis of warming middle-JIAO to dispel cold must be coordinated, to play the effect of the jaundice eliminating subcutaneous ulcer except YIN-cold.

Cortex Lycii: be the dry root bark of matrimony vine of solanaceae plant Lycium chinense Mill. or lycium barbarum Lycium barbarum L..Nature and flavor: sweet, cold.Return lung, liver, kidney channel.Function cures mainly: removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.Record in " book on Chinese herbal medicine is stated ": cure mainly deficient fever, alternate attacks of chills and fever, allly see blood disorder, epistaxis, cough blood, cough, breathe heavily, diseases due to endogenous heat of ZANG FU organs, apoplexy, dizzy, convulsion is chronic, lumbago, migratory arthralgia, beriberi, edema, and fidgets due to deficiency is throbbed with fear, forgetful, urinary obstruction, reddish and whitish turbid urine.

Radix Glehniae: be the dry root of samphire glehnia littoralis Glehnia littoralis Fr. Schmidt ex Miq..Nature and flavor: sweet, micro-hardship, to be slightly cold.Return lung, kidney channel.Effect: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.Thirsty for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound.Research display: Radix Glehniae not only has the effect of antipyretic-antalgic, can also strengthen body immunity.

The Rhizoma Anemarrhenae: be the dry rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bunge..Nature and flavor: bitter, sweet, cold.Return lung, stomach, kidney channel.Effect: clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.Rhizoma Anemarrhenae nature and flavor bitter cold and not dry, upper can lung heat clearing, the cool stomach of middle energy, can rush down kidney fire down.Be equipped with Radix Scutellariae, then purte the white; Join Gypsum Fibrosum, then clearing away stomach-heat; Join Cortex Phellodendri, then rush down kidney fire.The Rhizoma Anemarrhenae can excess-heat clearly, again can reducing the asthenic fever, but effect of its Yin-nourishing and body fluid promoting is more weak, for yin asthenia generating intrinsic heat, deficiency of the lung cough caused by dryness and the disease such as to quench one's thirst, must with drugs for nourishing yin compatibility, begin to play its effect.This product can moisturize laxation, therefore insufficiency of the spleen loose stool person should not use.

Radix Ophiopogonis: be the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..Nature and flavor: sweet, micro-hardship, to be slightly cold.GUIXIN, lung, stomach warp.Effect: reinforcing stomach reg fluid, nourishing lung-YIN, clear away heart-fire relieving restlessness.Radix Ophiopogonis can clear away heart-fire in yin nourishing, and relieving restlessness is calmed the nerves.The heart-nutriment, fever aggravated at night is entered with controlling warm febrile disease.Normal and Herba Dendrobii matches.

Herba Dendrobii: be orchid dendrobium loddigesii Rolfe Dendrobium loddigesii Rolfe., Herba Dendrobii oculati Dendrobium fimbriatum Hook. var. oculatum Hook., the fresh or dry stem of HERBA DENDROBII Dendrobium chrysanthum Wall., Herba Dendrobii Dendrobium candidum Wall. ex Lindl. or Dendrobium nobile Dendrobium nobile Lindl..Nature and flavor: be slightly cold; Sweet.Return stomach, kidney channel.Function: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.Herba Dendrobii has obvious therapeutical effect to ophthalmic diseases." explaining abstruseness of the canon of materia medica ": Herba Dendrobii, Gan Keyue spleen, salty energy kidney tonifying, therefore many merits are dirty in water and soil two.But gas is wide slow, without the merit that victory is played, ancients with this tea in generation, very clearly on diaphragm.

Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia/miltiorrhizaBge.Nature and flavor: bitter, are slightly cold.Gui Jing: enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed.Modern medicine experiment proves, Radix Salviae Miltiorrhizae also has anti-platelet aggregation, reduces the function of blood viscosity and the inside and outside blood coagulation system of adjustment, is the natural Chinese medicine that a kind of safety treats again thrombus disease reliably.

Flos Carthami: be the tubular corolla of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: temperature, pungent.GUIXIN, Liver Channel.Effect: clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.The pungent loose temperature of Flos Carthami is led to, and specially enters blood system, can blood circulation promoting and blood stasis dispelling, and stimulate the menstrual flow pulse-taking, and the mutual reinforcements between such as normal and Semen Persicae, Radix Angelicae Sinensis, Rhizoma Chuanxiong are for use.Flos Carthami has blood vessel dilating effect.Carthamus yellow can obviously extend blood plasma recalcification time, prothrombin time and clotting time." Amplification on Materia Medica addendum ": " Flos Carthami, broken stagnant blood, nourishes blood.Multiplex then removing blood stasis is few with then nourishing blood." crude extract from carthamus tinctorius L. with water has slight excited heart, increases the effect of coronary flow, have myocardial ischemia and alleviate effect, and make decreased heart rate, the amplitude that electrocardiogram S-T section is raised significantly declines, and also has anticoagulant and increases fibrinolysis activity.

Exocarpium Citri Rubrum: be the dry outside rind of rutaceae Huazhou Fructus Citri tangerinae Citrus grandis Osbeck var. tomentosa Hort. or Fructus Citri tangerinae Citrus reticulata Blanco and variety thereof.Nature and flavor: pungent, bitter, temperature.Return lung, spleen channel.Effect: cold expelling, dampness, promoting the circulation of QI, expectorant.For cough due to wind and cold, itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed." medicineization justice ": Exocarpium Citri Rubrum, pungently can walk crosswise eliminating stagnation, and bitter decline of keeping straight on is promoting the circulation of QI key medicine.Lid is controlled expectorant and must be regulated the flow of vital energy, the spontaneous recovery of diarrhea due to disorder of QI expectorant, therefore with entering lung spleen, all expectorant main are sick, and merit occupies on all expectorant medicines.Assistant Caulis Bambusae In Taenia, to treat heat-hiccup, helps Pericarpium Citri Reticulatae Viride with intestinal stasis relieving gas, real in the flat stomach of same Rhizoma Atractylodis, Cortex Magnoliae Officinalis, and the heresy that conjunction Bulbus Allii Fistulosi, Herba Ephedrae exterior cold are wet, rapid digestion of food gas, alcoholic intoxication, anti-nausea, opens chest and diaphragm painful abdominal mass plug, can push away Chen Zhixin, and the power that all pungent loose hardship is fallen also.

Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Nature and flavor: pungent, temperature.Return liver, gallbladder, heart channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.The pungent loose temperature of this product is led to, can top, up mountain peak, assigns the sea of blood, outer thorough fur, bypass extremity, can invigorate blood circulation and can circulation of qi promoting, and it is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.Rhizoma Chuanxiong has obvious sedation.The in vitro testses such as antibacterial action: Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.Rhizoma Chuanxiong water logging agent (1:3) also has inhibitory action to some pathogenic dermatophytes in vitro.

Flos Lonicerae: the flower that dry flower or band for caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera dasystyla Rehd. are just opened.Nature and flavor: sweet, cold.Return lung, the heart, stomach warp.Effect: heat-clearing and toxic substances removing, wind-dispelling heat-dissipating.This product is sweet in flavor and cold in property, can heat-clearing and toxic substances removing, again kind loose carbuncle detumescence, for treating the key medicine of all YANG syndrome carbuncle furuncle.Clinically for carbuncle furunculosis: be often equal to use with Herba Violae, Flos Chrysanthemi Indici, can antipyretic and antidote functions be strengthened, can in order to carbuncle furunculosis, congestion and swelling pain.

Herba Taraxaci: Herba Taraxaci, also known as bed-wetting grass, is feverfew Herba Taraxaci Toraxacum mongolicum Hand. Mazz., alkali ground Herba Taraxaci Toraxacum borealisinense Kitam. or the dry herb belonging to several plants together.Nature and flavor: sweet, micro-hardship, cold.Return liver, stomach warp.Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Herba Taraxaci has effect of antiinflammatory, antibacterial, antitumor, heat-clearing and toxic substances removing, and applied range on modern clinic, makes good use of.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Acute mastitis caused by pyretic toxicity is swollen and ache, furuncle has good effect, juice can be decocted separately and take orally, or external application local; Also the same use of other heat and toxic materials clearing away medicine can be coordinated, as Flos Lonicerae, Fructus Forsythiae, Herba Violae, Flos Chrysanthemi Indici, Radix Paeoniae Rubra etc.

Radix Scutellariae: be the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Nature and flavor: bitter, cold.Return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.The clinical practice of Radix Scutellariae is antibacterial relatively good, and does not develop immunity to drugs.This product has the merit of clearing away heat and cooling blood hemostasis, intimately flourishing with controlling, and the haematemesis of the absurd row of forcing blood, metrorrhagia, has blood in stool.

Radix Codonopsis: be the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis Codonopsis pilosula Nannf.var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Nature and flavor: sweet, flat.Return spleen, lung meridian.Effect: mend strengthening spleen and lung, nourishing blood to promote the production of body fluid.For deficiency of the spleen and lung, breathe hard, cardiopalmus, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst." Bencao Congxin " is recorded: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.Middle feeble QI is weak, mends in order to adjust, very smooth and proper." acid mucopolysaccharide in Radix Codonopsis has anticoagulant, can reduce blood fat and reduce blood viscosity and plasma viscosity, and have blood pressure lowering, blood fat reducing, antioxidation, defying age, improves the immunity of human body.Old myocardial infarction and cerebral thrombosis recovery phase are made moderate progress, has and purify the blood, prophylaxis of hypertension, the effect of cardiovascular and cerebrovascular disease.

Rhizoma Atractylodis Macrocephalae (parched): be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, the Rhizoma Atractylodis Macrocephalae can air making-up and spleen enlivening, again can dampness diuretic, is the key medicine of the spleen strengthening and damp drying.In the sweet temperature compensation of the Rhizoma Atractylodis Macrocephalae, can air making-up and spleen enlivening, also can strengthening superficial resistance to stop perspiration, and the Radix Astragali, Radix Pseudostellariae compatibility, play the merit of spleen reinforcing lung altogether.To rule together asthenia, the weak person of overstrain.Rhizoma Atractylodis Macrocephalae antibacterial action is obvious: infusion has inhibitory action to acrothesium floccosum, star nocardia in vitro.Decoct also has inhibitory action to meningococcus.The Rhizoma Atractylodis Macrocephalae also has the function promoting hemopoietic.

Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Sweet the providing additional supplies of this product is oozed, and not only mends but also sharp, and effect is gentle, and property is flat and partially without cold and heat, is the key medicine of promoting diuresis to eliminate damp pathogen.Treatment water wet the edema of expert time, often join Rhizoma Alismatis, Polyporus.Poria decoct has obvious sedation." modality ": " cure mainly Ji Rou Shun muscle of throbbing with fear cautious, dizziness agitation is controlled on side." this product is by heart-spleen boosting and tranquilizing mind.Be used for deficiency of both the heart and spleen, the irritability of insufficiency of vital energy and blood.

Radix Rehmanniae: be the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Nature and flavor: sweet, cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Can be used for Tianjin wound thirsty, interior-heat is quenched one's thirst.This product is sweet cold, can among heat clearing away YIN nourishing and the production of body fluid promoting, cold in nature and enter blood system, can not only the heat of clearing heat in YING system blood system and removing heat from blood, and sweet in the mouth is cold in nature can promote the production of body fluid, there is the effect of nourishing YIN and clearing away heat, be used for the treatment of heat in blood and tell nosebleed, metrorrhagia of having blood in stool, epidemic febrile disease heat enters nutrient blood, normal and Cortex Moutan, and Radix Paeoniae Rubra is with using.Research shows: the existing anastalsis of Radix Rehmanniae, has blood coagulation resisting function again.

Radix Glycyrrhizae Preparata: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Radix Glycyrrhizae Preparata is that processed goods smoked by the honey of Radix Glycyrrhizae.Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.

Side's solution of the present invention is: Rhizoma Polygonati boosting qi and nourishing yin, spleen invigorating lung moistening in side, Radix Astragali tonifying Qi and lifting yang, consolidating superficial resistance arresting sweating, Radix Stellariae clearind deficient heat, dispelling fever with infantile malnutrition, Rhizoma Phragmitis clearing away heat and promoting production of body fluid, Radix Puerariae induces sweat and brings down a fever, Rhizoma Imperatae cooling blood for hemostasis, clearing away heat and promoting diuresis, above Six-element is monarch drug altogether, fundamentally can carry out boosting qi and nourishing yin, spleen invigorating lung moistening, lung being a delicate viscus, easily by evil lung both aversion to heat, be afraid of again cold, outside it, close fur, main breathing, directly contacts with air.Exopathogen invades human body, no matter suck from mouth and nose, or attacked by skin, all easily violate lung and cause a disease, therefore lung is to support, and monarch drug carries out clearing away heat and promoting production of body fluid, spleen invigorating lung moistening on the whole, thus reaches conditioning health, the object of disease therapy.Herba Artemisiae Scopariae clearing away damp-heat, Cortex Lycii removing heat from blood is except steaming, lung heat clearing pathogenic fire reducing, Radix Glehniae nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid, the Rhizoma Anemarrhenae, Radix Ophiopogonis clearing away heat-fire, promote the production of body fluid and moisturize, Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat, Radix Salviae Miltiorrhizae clears away heart-fire relieving restlessness, nourishing blood to tranquillize the mind, above seven tastes not only can assist a ruler in governing a country monarch drug for ministerial drug altogether, weak, the symptom such as night sweat, loss of appetite caused by pulmonary sarcoidosis can also be treated, alleviate the sense of discomfort of patient, and then disease therapy.Flos Carthami clears away heart-fire relieving restlessness, nourishing blood to tranquillize the mind, Exocarpium Citri Rubrum promoting the circulation of QI, expectorant, Rhizoma Chuanxiong blood-activating and qi-promoting, Flos Lonicerae heat-clearing and toxic substances removing, wind-dispelling heat-dissipating, Herba Taraxaci heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, Radix Codonopsis mends strengthening spleen and lung, nourishing blood to promote the production of body fluid, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, above a few taste is adjuvant drug altogether, strengthen patient's body constitution, reduce poisonous side effect of medicine, reduce the injury to patient body, Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription, priming return through, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has effect of boosting qi and nourishing yin, spleen invigorating lung moistening, clearing away heat and promoting production of body fluid, effectively can treat pulmonary sarcoidosis.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Rhizoma Polygonati 15-25 part, Radix Astragali 25-35 part, Radix Stellariae 10-20 part, Rhizoma Phragmitis 19-29 part, Radix Puerariae 10-20 part, Rhizoma Imperatae 19-29 part, Herba Artemisiae Scopariae 19-29 part, Cortex Lycii 15-25 part, Radix Glehniae 15-25 part, Rhizoma Anemarrhenae 7-17 part, Radix Ophiopogonis 10-20 part, Herba Dendrobii 10-20 part, Radix Salviae Miltiorrhizae 19-29 part, Flos Carthami 5-15 part, Exocarpium Citri Rubrum 7-17 part, Rhizoma Chuanxiong 10-20 part, Flos Lonicerae 10-20 part, Herba Taraxaci 15-25 part, Radix Scutellariae 10-20 part, Radix Codonopsis 13-23 part, Rhizoma Atractylodis Macrocephalae (parched) 19-29 part, Poria 10-20 part, Radix Rehmanniae 15-25 part, Radix Glycyrrhizae Preparata 4-14 part.

Wherein be preferably: Rhizoma Polygonati 20 parts, the Radix Astragali 30 parts, Radix Stellariae 15 parts, Rhizoma Phragmitis 24 parts, Radix Puerariae 15 parts, Rhizoma Imperatae 24 parts, Herba Artemisiae Scopariae 24 parts, Cortex Lycii 20 parts, Radix Glehniae 20 parts, the Rhizoma Anemarrhenae 12 parts, Radix Ophiopogonis 15 parts, Herba Dendrobii 15 parts, Radix Salviae Miltiorrhizae 24 parts, 10 parts, Flos Carthami, Exocarpium Citri Rubrum 12 parts, Rhizoma Chuanxiong 15 parts, Flos Lonicerae 15 parts, Herba Taraxaci 20 parts, Radix Scutellariae 15 parts, Radix Codonopsis 18 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 15 parts, Poria, Radix Rehmanniae 20 parts, Radix Glycyrrhizae Preparata 9 parts.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug pulverize mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.

The preferred preparation method of the present invention is granule, and its preparation method is as follows:

Step one: by weight proportion of the present invention, take Rhizoma Polygonati, the Radix Astragali, Radix Stellariae, Rhizoma Phragmitis, Radix Puerariae, Rhizoma Imperatae, Cortex Lycii, Radix Glehniae, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Radix Scutellariae, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Radix Rehmanniae is put into marmite and is added cold water, exceed the horizontal finger of powder 3-4, after being fried boiling with high heat, again with 20-30 minute at a simmer, filter, obtain filtrate, the horizontal finger water of 2-3 is added in residue medicinal residues, then Herba Artemisiae Scopariae is added, Herba Dendrobii, Rhizoma Chuanxiong, Herba Taraxaci, Poria, continue to decoct 20-30 minute, finally add Flos Carthami, Fructus Citri tangerinae is red, Flos Lonicerae, Radix Glycyrrhizae Preparata decocts 10 minutes, filter, waste, obtain filtrate, merge twice filtrate, for subsequent use,

Step 2: the medicinal liquid in step one is concentrated, add 75% ethanol, place precipitation, filtrate recycling ethanol, the thick paste of relative density 1.13 ~ 1.20 under 60 DEG C of environment, then thick paste be dry, pulverize into fine powder, add appropriate Icing Sugar as diluent, ethanol as wetting agent and microcrystalline Cellulose as disintegrating agent, adopt dry granulation, make graininess, both the granule for the treatment of pulmonary sarcoidosis of the present invention.

Medicine of the present invention has effect of boosting qi and nourishing yin, spleen invigorating lung moistening, clearing away heat and promoting production of body fluid, and determined curative effect, cheap, safe ready, side effect is little, and the mode that this Chinese medicine preparation adopts treats the torment can removed in slight illness that pulmonary sarcoidosis brings to patient, according to clinical 150 routine patient view's statistics, use medicine of the present invention the total effective rate course for the treatment of 86%, two the total effective rate course for the treatment of 96%.

Detailed description of the invention

Embodiment one, Rhizoma Polygonati 15 parts, the Radix Astragali 25 parts, Radix Stellariae 10 parts, Rhizoma Phragmitis 19 parts, Radix Puerariae 10 parts, Rhizoma Imperatae 19 parts, Herba Artemisiae Scopariae 19 parts, Cortex Lycii 15 parts, Radix Glehniae 15 parts, the Rhizoma Anemarrhenae 7 parts, Radix Ophiopogonis 10 parts, Herba Dendrobii 10 parts, Radix Salviae Miltiorrhizae 19 parts, 5 parts, Flos Carthami, Exocarpium Citri Rubrum 7 parts, Rhizoma Chuanxiong 10 parts, Flos Lonicerae 10 parts, Herba Taraxaci 15 parts, Radix Scutellariae 10 parts, Radix Codonopsis 13 parts, Rhizoma Atractylodis Macrocephalae (parched) 19 parts, 10 parts, Poria, Radix Rehmanniae 15 parts, Radix Glycyrrhizae Preparata 4 parts.

Embodiment two, Rhizoma Polygonati 20 parts, the Radix Astragali 30 parts, Radix Stellariae 15 parts, Rhizoma Phragmitis 24 parts, Radix Puerariae 15 parts, Rhizoma Imperatae 24 parts, Herba Artemisiae Scopariae 24 parts, Cortex Lycii 20 parts, Radix Glehniae 20 parts, the Rhizoma Anemarrhenae 12 parts, Radix Ophiopogonis 15 parts, Herba Dendrobii 15 parts, Radix Salviae Miltiorrhizae 24 parts, 10 parts, Flos Carthami, Exocarpium Citri Rubrum 12 parts, Rhizoma Chuanxiong 15 parts, Flos Lonicerae 15 parts, Herba Taraxaci 20 parts, Radix Scutellariae 15 parts, Radix Codonopsis 18 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 15 parts, Poria, Radix Rehmanniae 20 parts, Radix Glycyrrhizae Preparata 9 parts.

Embodiment three, Rhizoma Polygonati 25 parts, the Radix Astragali 35 parts, Radix Stellariae 20 parts, Rhizoma Phragmitis 29 parts, Radix Puerariae 20 parts, Rhizoma Imperatae 29 parts, Herba Artemisiae Scopariae 29 parts, Cortex Lycii 25 parts, Radix Glehniae 25 parts, the Rhizoma Anemarrhenae 17 parts, Radix Ophiopogonis 20 parts, Herba Dendrobii 20 parts, Radix Salviae Miltiorrhizae 29 parts, 15 parts, Flos Carthami, Exocarpium Citri Rubrum 17 parts, Rhizoma Chuanxiong 20 parts, Flos Lonicerae 20 parts, Herba Taraxaci 25 parts, Radix Scutellariae 20 parts, Radix Codonopsis 23 parts, Rhizoma Atractylodis Macrocephalae (parched) 29 parts, 20 parts, Poria, Radix Rehmanniae 25 parts, Radix Glycyrrhizae Preparata 14 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data:

Accept out-patient 150 example for medical treatment, wherein male 64 example, women 86 example, M-F 1:1.3,37 years old mean age, the course of disease time is not etc.

Two, Therapeutic Method:

According to Medications Example two of the present invention, and preparation prepared by selected preparation method, every day 3 times, each one bag 20 days is a course for the treatment of.

Three, efficacy assessment standard:

1, cure: the clinical symptoms such as pulmonary sarcoidosis transference cure, cough, uncomfortable in chest, expectorant blood disappear completely, and health is taken a turn for the better, and every inspection is all normal;

2, effective: pulmonary sarcoidosis symptom disappears substantially, the clinical symptoms such as cough, uncomfortable in chest, expectorant blood are eased, and every inspection all makes moderate progress;

3, invalid: pulmonary sarcoidosis symptom is without any improvement, and every inspection is without significant change.

Four, therapeutic outcome statistics

Wherein: total effective rate=cure rate+improvement rate

By the observation added up therapeutic outcome, the total effective rate of two courses for the treatment of, up to 96%, illustrates thus, and Chinese medicine of the present invention has good clinical effectiveness in treatment pulmonary sarcoidosis, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.

Model case and curative effect:

Case one, patient Lu, female, 40 years old, patient has pneumonia always, there is chest pain in the recent period, the symptom of feeling suffocated, sometimes also there will be arthralgic phenomenon, patient goes to hospital to check comprehensively, finally be diagnosed as pulmonary sarcoidosis, adopt made preparation in the embodiment of the present invention two, and selected preparation method, after taking treatment a period of time, patient's chest pain, the symptom of feeling suffocated obviously is alleviated, arthralgic phenomenon also improves, for consolidate curative effect, patient continues to take two courses for the treatment of, somatosensory is clearly better, body constitution is enhanced, each clinical symptoms disappears completely, patient goes to hospital to check, indices is all normal, recovery from illness.

Case two, patient Meng, man, 40 years old, there is serious diaphoresis in patient, night sweat, and there is dry cough more than, the phenomenon of breathing hard, patient's extremity also have erythra to occur, so remove examination in hospital, finally be diagnosed as pulmonary sarcoidosis, adopt made preparation in the embodiment of the present invention two, and selected preparation method, after taking a course for the treatment of, patient's Schultz-Charlton, diaphoresis, night sweat phenomenon is eased, body constitution improves, patient continues to take a course for the treatment of, dry cough, phenomenon of breathing hard also fades away, for consolidate curative effect, patient adheres to taking a course for the treatment of, hospital is gone to check, indices all improves, body constitution strengthens, symptom disappears completely, recovery from illness.

Claims (4)

1. treat the Chinese medicine preparation of pulmonary sarcoidosis for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Rhizoma Polygonati 15-25 part, Radix Astragali 25-35 part, Radix Stellariae 10-20 part, Rhizoma Phragmitis 19-29 part, Radix Puerariae 10-20 part, Rhizoma Imperatae 19-29 part, Herba Artemisiae Scopariae 19-29 part, Cortex Lycii 15-25 part, Radix Glehniae 15-25 part, Rhizoma Anemarrhenae 7-17 part, Radix Ophiopogonis 10-20 part, Herba Dendrobii 10-20 part, Radix Salviae Miltiorrhizae 19-29 part, Flos Carthami 5-15 part, Exocarpium Citri Rubrum 7-17 part, Rhizoma Chuanxiong 10-20 part, Flos Lonicerae 10-20 part, Herba Taraxaci 15-25 part, Radix Scutellariae 10-20 part, Radix Codonopsis 13-23 part, Rhizoma Atractylodis Macrocephalae (parched) 19-29 part, Poria 10-20 part, Radix Rehmanniae 15-25 part, Radix Glycyrrhizae Preparata 4-14 part.

2. the Chinese medicine preparation for the treatment of pulmonary sarcoidosis according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Rhizoma Polygonati 20 parts, the Radix Astragali 30 parts, Radix Stellariae 15 parts, Rhizoma Phragmitis 24 parts, Radix Puerariae 15 parts, Rhizoma Imperatae 24 parts, Herba Artemisiae Scopariae 24 parts, Cortex Lycii 20 parts, Radix Glehniae 20 parts, the Rhizoma Anemarrhenae 12 parts, Radix Ophiopogonis 15 parts, Herba Dendrobii 15 parts, Radix Salviae Miltiorrhizae 24 parts, 10 parts, Flos Carthami, Exocarpium Citri Rubrum 12 parts, Rhizoma Chuanxiong 15 parts, Flos Lonicerae 15 parts, Herba Taraxaci 20 parts, Radix Scutellariae 15 parts, Radix Codonopsis 18 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 15 parts, Poria, Radix Rehmanniae 20 parts, Radix Glycyrrhizae Preparata 9 parts.

3. the Chinese medicine preparation for the treatment of pulmonary sarcoidosis according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is granule.

4. treat the preparation method of the Chinese medicine preparation of pulmonary sarcoidosis for one kind, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, take Rhizoma Polygonati, the Radix Astragali, Radix Stellariae, Rhizoma Phragmitis, Radix Puerariae, Rhizoma Imperatae, Cortex Lycii, Radix Glehniae, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Radix Scutellariae, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Radix Rehmanniae is put into marmite and is added cold water, exceed the horizontal finger of powder 3-4, after being fried boiling with high heat, again with 20-30 minute at a simmer, filter, obtain filtrate, the horizontal finger water of 2-3 is added in residue medicinal residues, then Herba Artemisiae Scopariae is added, Herba Dendrobii, Rhizoma Chuanxiong, Herba Taraxaci, Poria, continue to decoct 20-30 minute, finally add Flos Carthami, Fructus Citri tangerinae is red, Flos Lonicerae, Radix Glycyrrhizae Preparata decocts 10 minutes, filter, waste, obtain filtrate, merge twice filtrate, for subsequent use, step 2: the medicinal liquid in step one is concentrated, add 75% ethanol, place precipitation, filtrate recycling ethanol, the thick paste of relative density 1.13 ~ 1.20 under 60 DEG C of environment, then thick paste be dry, pulverize into fine powder, add appropriate Icing Sugar as diluent, ethanol as wetting agent and microcrystalline Cellulose as disintegrating agent, adopt dry granulation, make graininess, both the granule for the treatment of pulmonary sarcoidosis of the present invention.