CN104689252A - Traditional Chinese preparation for treating Wegener granulomatosis and preparation method thereof - Google Patents
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Abstract
The invention discloses a traditional Chinese preparation for treating Wegener granulomatosis. The traditional Chinese preparation is composed of radix astragali, radix codonopsis, fried atractylodes macrocephala koidz, poria cocos, parched white peony root, angelica sinensis, sedum rosea, rhizoma chuanxiong, salviae miltiorrhizae, fried peach seeds, flos carthami, dipsacus asperoids, eucommia ulmoides, fructus psoraleae, cassia twig, hirudo, trogopterus dung, olibanum, myrrh, corydalis yanhusuo, curcuma, rhizoma phragmitis, polygonatum kingianum, rhizoma imperatae, puerarin and crude radix glycyrrhizae according to a weight ratio. The traditional Chinese preparation has the effects of tonifying Qi, lifting yang, clearing damp, promoting diuresis, tonifying the liver and kidney, strengthening spleen, calming the heart and the like, and can effectively treat the Wegener granulomatosis.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to one and treat the granulomatous Chinese medicine preparation of Wei lattice.The invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Wei lattice granuloma also known as Witt theorem (wegener's granulomatosis) be with necrosis progrediens granuloma and widely polyangitis for basic feature.Mainly involve the internal organs such as respiratory tract, kidney, skin and produce corresponding clinical manifestation.Men and women all can occur, and M-F is 3:2, and age of onset more than half is 30 ~ 50 years old.Most patient has heating, loses weight, weak, arthralgia, myalgia etc., and typical performance is upper respiratory tract, lung and kidney pathological changes triad shape.Whole body system and internal organs all can be got involved, pathological characteristic has: 1. respiratory tract top (nose, paranasal sinus, nasopharynx part, nasal septum is main) or bottom (trachea, bronchus and lung) granuloma gangraenescens sexually transmitted disease (STD) all can be had to become, thin vessels tube wall cellulose sample is bad, and holostrome has mononuclear cell, epithelioid cell and multinucleated giant cell infiltrate; can invade sclerotin when pathological changes is serious and cause destruction, and pulmonary lesion can have cavity to be formed, and granuloma also sees the place such as upper jaw bone, sieve skeleton eye socket.The infarction that causes of vasculitis and ulcer cause saddle nose deformity widely, exophthalmos etc.2. nephropathy is the change of necrotizing glomerulonephritis, glomerular capillary stove or segmental necrosis, and neutrophilia and eosinophilic granulocyte's blood vessel wall have IgG, IgM, C3, the depositions such as C4, and thin vessels wall has fibrin sample to become raw.3. general focal necrosis vasculitis, main infringement small artery, arteriole, venule, blood capillary and surrounding tissue thereof, blood vessel wall has PMN infiltration, fibrinoid degeneration, muscle layer and elastic fibers destroy, thrombosis in tube chamber, and tube wall is downright bad, form microaneurysm, hemorrhage etc., except lung, kidney, skin, cardiovascular, digestion, the system such as neural all can be got involved.
Current is adopt the treatment of topical type x-ray to the granulomatous treatment of Wei lattice, for early stage patient compliance's immunosuppressant, also has certain therapeutic effect, but for the patient of middle and advanced stage, this method does not have any effect substantially, x-ray treatment is carried out to patient and to a great extent damage is caused to the health of patient, be unfavorable for the recovery that patient is follow-up.This type of disease of Chinese traditional treatment is then the method adopting determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, overall conditioning, while strengthening patient's body constitution, thus reaches the object for the treatment of.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation, it is obvious that this Chinese medicine preparation has curative effect for treatment Wei lattice granuloma, and side effect is little, taking convenience, cheap, the feature not easily recurred.
Another object of the present invention is to provide the preparation method of the granulomatous Chinese medicine preparation of these treatment Wei lattice.
Inventor is in clinical treatment practice for many years, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the granulomatous Chinese medicine preparation of Wei lattice repeatedly, the present invention selects the Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Poria, Radix Paeoniae Alba (parched), Radix Angelicae Sinensis, Radix Rhodiolae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Semen Persicae (parched), Flos Carthami, Radix Dipsaci, the Cortex Eucommiae, Fructus Psoraleae, Ramulus Cinnamomi, Hirudo, Oletum Trogopterori, Olibanum, Myrrha, Rhizoma Corydalis, Radix Curcumae, Rhizoma Phragmitis, Rhizoma Polygonati, Rhizoma Imperatae, Radix Puerariae, Radix Glycyrrhizae combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is tonifying Qi and lifting yang, promoting diuresis to eliminate damp pathogen, liver and kidney tonifying, effect of spleen invigorating mind calming, thus effectively can treat Wei lattice granuloma.
The effect of Chinese medicine of the present invention:
Wherein:
The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.Effect: tonifying Qi and lifting yang, consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.On the books in " book on Chinese herbal medicine converges and says ": " Radix Astragali, tonifying the lung spleen invigorating defend arresting sweating in fact, and the medicine of wind dispelling fortune poison also.Therefore the people of yang deficiency, spontaneous perspiration frequently comes, be exterior deficiency and interspaces of skin and muscles being loose also, he the Radix Astragali can be defended and arresting sweating in fact; The card of typhoid fever, row is delivered and evil no sweating, and be interior deficiency and also weary in healthy energy, the Radix Astragali can help Tianjin to help antiperspirant; The disease of harmful wind, inclined invasion of vessels and brothers are not with person, and the Radix Astragali can flourish muscles and bones; The card of carbuncle and ulcer, pus and blood internal ulceration, deficiency of YANG QI and do not hold back person, the Radix Astragali can granulation promoting meat, and the erosion of vulva can not rise and send out again, deficiency of YANG QI and unhealed, and the Radix Astragali can granulation promoting meat." this product all has inhibitory action to dysentery bacterium, anthrax bacillus, α-hemolytic streptococcus, beta hemolytic streptococcus, diphtheria corynebacterium, bacillus pseudodiphthericus, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, bacillus subtilis etc. in vitro.
Radix Codonopsis: be the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis Codonopsis pilosula Nannf.var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Nature and flavor: sweet, flat.Return spleen, lung meridian.Effect: mend strengthening spleen and lung, nourishing blood to promote the production of body fluid.For deficiency of the spleen and lung, breathe hard, cardiopalmus, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst." Bencao Congxin " is recorded: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.Middle feeble QI is weak, mends in order to adjust, very smooth and proper." acid mucopolysaccharide in Radix Codonopsis has anticoagulant, can reduce blood fat and reduce blood viscosity and plasma viscosity, and have blood pressure lowering, blood fat reducing, antioxidation, defying age, improves the immunity of human body.
Rhizoma Atractylodis Macrocephalae (parched): be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, the Rhizoma Atractylodis Macrocephalae and Poria with the use of, spleen invigorating eliminating dampness by diuresis, as a means of the source changing life, helps the spleen reinforcing of Radix Codonopsis QI invigorating.The Rhizoma Atractylodis Macrocephalae can air making-up and spleen enlivening, again can dampness diuretic, is the key medicine of the spleen strengthening and damp drying.Rhizoma Atractylodis Macrocephalae antibacterial action is obvious: infusion has inhibitory action to acrothesium floccosum, star nocardia in vitro.Decoct also has inhibitory action to meningococcus.The Rhizoma Atractylodis Macrocephalae also has the function promoting hemopoietic.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Sweet the providing additional supplies of this product is oozed, and not only mends but also sharp, and effect is gentle, and property is flat and partially without cold and heat, is the key medicine of promoting diuresis to eliminate damp pathogen.Poria decoct has obvious sedation." modality ": " cure mainly Ji Rou Shun muscle of throbbing with fear cautious, dizziness agitation is controlled on side." this product is by heart-spleen boosting and tranquilizing mind.Be used for deficiency of both the heart and spleen, the irritability of insufficiency of vital energy and blood.
Radix Paeoniae Alba (parched): be the dry root of dicotyledon ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: cool, picric acid, is slightly cold.Effect: easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receives antiperspirant.Radix Paeoniae Alba (parched) is slightly slow than the Radix Paeoniae Alba property of medicine, based on the yin fluid astringing that nourishes blood.Be longer than the regulating liver-QI that nourishes blood after stir-fry, be used for the insufficiency of the spleen pain of the liver-yang hyperactivity person of rushing down, joint venture of enriching blood in this side, the spleen and stomach regulating, is conducive to the absorption of other drug.Research shows: the paeoniflorin contained in the Radix Paeoniae Alba has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.This product energy nourishing the liver blood, holding back liver-yin, subduing the hyperfunction of the liver sun, dispersing liver-energy, can delay again that contraction is anxious, relieve the pain pain, is the good medicine of the various pain for the treatment of Liver Channel.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis has inhibitory action to central nervous system, and volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia.For blood deficiency and yellow complexion, dizzy cardiopalmus, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores.Carry according to " book on Chinese herbal medicine is just ": " its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, nothing unsuitable." modern medicine study confirmation, Radix Angelicae Sinensis has antibacterial, antiinflammation.
Radix Rhodiolae: be Crassulaceae Rhodida plant Radix Rhodiolae Rhodiola saera (Prain) Fu, with all herbal medicine.Nature and flavor: sweet, puckery, cold.Effect: QI invigorating lung heat clearing; Fructus Alpiniae Oxyphyllae is nourished heart; Hemostasis with astringents; Dissipating blood stasis for subsidence of swelling.Main deficiency of vital energy and physically weak; Fear of cold after being ill; Shortness of breath and fatigue; Cough due to lung-heat; Spitting of blood; Leucorrhea is suffered from diarrhoea; Traumatic injury; Burn and scald; Neurosis; Altitude sickness.
Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Nature and flavor: pungent, temperature.Return liver, gallbladder, heart channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.The pungent loose temperature of this product is led to, can top, up mountain peak, assigns the sea of blood, outer thorough fur, bypass extremity, can invigorate blood circulation and can circulation of qi promoting, and it is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.Rhizoma Chuanxiong has obvious sedation.The in vitro testses such as antibacterial action: Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.Rhizoma Chuanxiong water logging agent (1:3) also has inhibitory action to some pathogenic dermatophytes in vitro.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia/miltiorrhizaBge.Nature and flavor: bitter, are slightly cold.Gui Jing: enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed.For costa sternales hypochondriac pain, improve liver microcirculation, can suppress or alleviate hepatocellular degeneration, necrosis and inflammatory reaction, promote liver cell regeneration.
Semen Persicae (parched): be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Nature and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.The power of Semen Persicae blood stasis dispelling is comparatively strong, also known as stasis-breaking drug, is used for the treatment of blood stasis, WEIJIA, often joins Flos Carthami, Radix Angelicae Sinensis.Semen Persicae is improved effect to blood flow retardance, blood obstacle, and each internal organs can be made respectively to organize functional recovery normal.
Flos Carthami: be the tubular corolla of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: temperature, pungent.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.The pungent loose temperature of Flos Carthami is led to, and specially enters blood system, can blood circulation promoting and blood stasis dispelling, and stimulate the menstrual flow pulse-taking, and the mutual reinforcements between such as normal and Semen Persicae, Radix Angelicae Sinensis, Rhizoma Chuanxiong are for use.Flos Carthami has blood vessel dilating effect.Carthamus yellow can obviously extend blood plasma recalcification time, prothrombin time and clotting time." Amplification on Materia Medica addendum ": Flos Carthami, broken stagnant blood, nourishes blood.Multiplex then removing blood stasis is few with then nourishing blood.
Radix Dipsaci: be the dry root of Dipsacaceae plant Radix Dipsaci Dipsacus asperoides C. Y. Cheng et T. M. Ai (or Dipsacus asper Wall).Nature and flavor: bitter, pungent, tepor.Return liver, kidney channel.Effect: invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Only metrorrhagia, controls aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, and carbuncle skin ulcer swells.The sweet temperature of this product is supporing yang, pungent temperature cold expelling, and with controlling insufficiency of kidney-YANG, below element deficiency and cold, sexual impotence erectile problem, seminal emission lingering diarrhea, the diseases such as enuresis frequent micturition, have liver and kidney tonifying concurrently, strong bone strengthening, the merit of promoting blood circulation.
The Cortex Eucommiae: be the dry bark of the Eucommiaceae plant Cortex Eucommiae (Eucommia ulmoides Oliver).Nature and flavor: sweet, temperature.Return liver, kidney, stomach warp.Effect: liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, solid through antiabortive.Compendium of Material Medica: the Cortex Eucommiae, ancient prescription only knows nourishing kidney, and only Wang Haogu speech is Liver Channel edema caused by disorder of QI medicine, and profit liver is dry, and tonifying liver is empty, sends out former times people and does not send out also.Lid liver governing tendons, kidney governing bones, it is strong that kidney fills then bone, and liver is filled then muscle and is good for, and bends and stretches utilization, all belongs to muscle.The all energy invigorating the liver and kidney of the Cortex Eucommiae and Radix Dipsaci, bone and muscle strengthening, is used for the treatment of deficiency of the liver and kindey, with the passing of time, Chang Xiangxu is use to the strong and arthromyodynia of muscles and bones, but the double sexual impotence, frequent micturition etc. controlling insufficiency of kidney-YANG of the Cortex Eucommiae, and Radix Dipsaci can continue injured, for traumatic injury, bruise and fracture etc.
Fructus Psoraleae: be the fruit of legumes psoraleae Psoralea corylifolia L..Nature and flavor: pungent, bitter, temperature.Return kidney, spleen channel.Effect: kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, helping inspiration to relieve asthma.This product energy kidney-replenishing, warm spleen sun, stopping leak rushes down, for controlling the key medicine of deficiency of spleen-YANG and kidneyYANG.This product is worked hard warm-dryness syndrome, can warming and recuperating the gate of life, and replenishing kidney, strengthening waist, tonifying YANG, controlling nocturnal emission with astringent drugs, reducing urination, for controlling the key medicine of insufficiency of kidney-YANG, instability of kidney-QI.Modern age works out again, and the effective ingredient in Fructus Psoraleae has the effect of blood vessel dilating.
Ramulus Cinnamomi: be the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor: acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Cure mainly exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; WEIJIA is lumpd; The thoracic obstruction; Cardiopalmus; Phlegm retention." Changsha medicine solution " carries: " enter liver man and promoting the circulation of blood divides, determine meridians and reach Rong Yu.Kind solution ailment said due to cold or exposure, adjusts wood gas most.The detrapping of sending up the lucid YANG, the punching of the turbid descending the moon is inverse, the anxious contraction of relaxing muscles and tendons feeling pulse; The heap soil or fertilizer over and around the roots resistance in profit joint, fall apart and suppress, pain relieving Chu, the meridian dredging, opens numbness puckery, very dries cold.Only renal mass, more pacifies palpitation with fear." modern medicine study confirm, Ramulus Cinnamomi can effectively blood vessel dilating, promote diaphoresis, contained cinnamic aldehyde, natrium cinnamicum have antipyretic, analgesia, calmness, anticonvulsant action, in addition Ramulus Cinnamomi antibacterial, antiviral effect in addition.Ramulus Cinnamomi is warm in nature, and the kind gas that activates yang, can change YIN-cold, temperature three-way meridian, for all pain cards of congealing cold with blood stasis.
Hirudo: be the dry body of Hirudinidae animal whitmania Whitmania pigra Whitman, Hirudo Hirudo nipponica Whitman or Folium Salicis Babylonicae Hirudo Whit-mania acranulata Whitman.Nature and flavor: salty, bitter, flat, slightly poisonous.Return Liver Channel.There is removing blood stasis, removing blood stasis, the effect of stimulating the menstrual flow, Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, injury from falling down.The salty hardship of Hirudo enters blood system, is good at removing blood stasis by silt, and the high effect of power is grand, and modern age is clinical in controlling thrombocytosis, and decoction in short-term has certain curative effect, controls cerebral hemorrhage, intracranial hematoma, has good curative effect.
Oletum Trogopterori: be flying squirrel section animal trogopterus xanthipes Trogopterus Xanthipes Milne-Edwards or the dry feces flying murine little flying squirrel Pteromys volans L..Nature and flavor: sweet, temperature.Enter liver, spleen channel.Effect: promoting blood circulation to remove blood stasis, parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.
Olibanum: the resin oozed out for Burseraceae Boswellia carterii platymiscium Boswellia carterii Boswellia carterii Birdw. [B. sacra Fluek.], medicine glue XIANGSHU B. bhawdajiana Birdw. and congener skin zone thereof.Nature and flavor: acrid, bitter, warm.GUIXIN, liver, spleen channel.Effect: promoting blood circulation and stopping pain, detumescence and promoting granulation.This product does not close up after being used for skin infection for a long time, and Chang Yuyu Myrrha compatibility, spreads on affected part outward.
Myrrha: the oleo-gum-resin of oozing out for Burseraceae bdellium plant myrrh Commiphora myrrha Engl. [C. molmol Engl.] and the trunk skin zone that belongs to his kind of plant together.Nature and flavor: bitter, flat.Enter Liver Channel.Effect: loose blood blood stasis removing, subduing swelling and relieving pain.Can be used for clinically treating acute mastitis.
Rhizoma Corydalis: be the dry tuber of papaveraceae plant corydalis Corydalis yanhusuo W. T. Wang.Nature and flavor: acrid, bitter, warm.Return liver, spleen channel.Effect: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.The pungent loose temperature of this product is led to, the stagnation of QI in energy promoting the circulation of blood, stasis in gas, blood-activating and qi-promoting pain relieving, and the kind multiple pain controlled caused by stagnation of QI and blood, its analgesic effect is excellent.
Radix Curcumae: be the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor: pungent, bitter, cold.Return liver, the heart, lung meridian.Effect: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, removing heat from blood removing blood stasis with potent drugs.Cure mainly: all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.The pungent loose hardship of this product is let out, heat clearing away cold in nature, can have one's ideas straightened out by heart fire-clearing upset-relieving.Radix Curcumae pungent drugs can disperse and bitter drugs can descend, fragrance a surname reach, cold in nature again can heat clearing away.Both entered edema caused by disorder of QI with promoting QI circulation for relieving depression, entered again blood system with cooling blood and dissolving stasis, and be the gas medicine in blood, be used for the treatment of the chest pain of QI and blood stasis.
Rhizoma Phragmitis: be the fresh or dry rhizome of grass phragmites communis Phragmites communis Trin..Nature and flavor: sweet, cold.Return lung meridian, stomach warp.Function: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Though Rhizoma Phragmitis attribute is trembled with fear, slightly sweet flavor and power use lung heat clearing stomach, can only as auxiliary medicine.But, it has an advantage, and namely property is not grown greasy, promotes the production of body fluid and does not love heresy, and all epidemic febrile disease deep loves are defended, gas, or if any the syndrome that impairment of body fluid is thirsty after calentura, all can apply.
Rhizoma Polygonati: be the dry rhizome of liliaceous plant P. kingianum Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor: sweet are flat.Return spleen, lung, kidney channel.Effect: boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst." book on Chinese herbal medicine is just read ": Rhizoma Polygonati, for growing greasy product, clothes of a specified duration make us not hungry, have wet person if insufficiency of the spleen, should not take it, and probably its greasy diaphragm also.These flavour of a drug are sweet as maltosemalt sugar, and the flat matter profit of property is the certified products of tonic spleen the moon.
Rhizoma Imperatae: be the rhizome of grass perennial herb Herba Imperatae Imperata cylindrica.Nature and flavor: sweet, cold.Return lung, stomach, urinary bladder channel.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema." Bencao Jingshu " is recorded: impairment caused by overstrain void is won, must interior-heat, and Rhizoma Imperatae is sweet can spleen reinforcing, sweet, though cold and do not violate stomach.Gan Hanneng is except interior-heat, therefore main impairment caused by overstrain void is won.Strengthening the spleen so invigorating middle warmer, heat extraction so QI invigorating, the beneficial blood of sweet energy, heat in blood is the stasis of blood then, and the stasis of blood is then closed, and closes then cold and heat and does, cold and cool blood, sweet beneficial blood, heat go then blood and, and then stagnation resolvation and close logical, general rule cold and heat are from only also.Dysuria, due to interior-heat also, pyrolysis then just diarrhea.Pouring person, caused by blood system deficiency-heat also, removing heat from blood benefit blood, then drench spontaneous recovery, and the exopathogenic heat of the intestines and stomach is explained by oneself, and body fluid is raw and yearningly also stop.Blood stored in the liver and main muscle, cool liver of enriching blood, then muscle is hard.Heat in blood then collapses, and removing heat from blood and blood, then collapse spontaneous recovery.Heat in blood is absurd row then, overflow upper orifices for telling, for coughing up, be epistaxis, bleeding from the gum, removing heat from blood and blood, then all cards are from removing.Strengthening the spleen invigorating middle warmer, diuresis, therefore swollen jaundice of also harnessing the river, and hold concurrently reason typhoid fever hiccup also.
Radix Puerariae: be the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.Nature and flavor: cool, sweet, pungent.Enter spleen, stomach warp.Effect: induce sweat and bring down a fever, promotes the production of body fluid, rash, yang invigorating antidiarrheal.Radix Puerariae is sweet pungent cool in nature, and lightly floating, it is loose to rise, and enters taste warp, has relieving the exterior syndrome by diaphoresis, the merit of expelling pathogenic factors from muscles for reducing heat.Radix Puerariae has treating measles effect, promotes the production of body fluid, diarrhea-relieving function because it has concurrently.
Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.
Side's solution of the present invention is: Radix Astragali tonifying Qi and lifting yang, inducing diuresis to remove edema in side, Radix Codonopsis mends strengthening spleen and lung, nourishing blood to promote the production of body fluid, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, Radix Paeoniae Alba (parched) enrich blood easing the affected liver, yin fluid astringing receive antiperspirant, Chinese angelica blood supplementing is invigorated blood circulation, above Six-element is monarch drug altogether, monarch drug nurses one's health the body of patient on the whole, because this disease involves multiple internal organs, therefore first to improve entire patient's body constitution, and then the situation of the entirety of patient is got a promotion, reach the object of disease therapy.The lung heat clearing of Radix Rhodiolae QI invigorating, Fructus Alpiniae Oxyphyllae is nourished heart, Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping, Radix Salviae Miltiorrhizae is reposed sedate, tonneau GUAN-pulse, Semen Persicae (parched), Flos Carthami blood circulation promoting and blood stasis dispelling, Radix Dipsaci, Cortex Eucommiae liver and kidney tonifying, bone and muscle strengthening, Fructus Psoraleae kidney invigorating and YANG supporting, above eight tastes are ministerial drug altogether, Radix Rhodiolae can be good at lung heat clearing, the rhinorrhea that upper respiratory tract shows can be alleviated, the symptoms such as rhinorrhea, Semen Persicae (parched), the many blood circulation promoting and blood stasis dispelling of Flos Carthami, the purpura that this disease is brought can be treated, the symptom of wellability speckle, Radix Dipsaci, the liver and kidney tonifying such as the Cortex Eucommiae, bone and muscle strengthening, the exhaustion of kidney all can occur in the nearly all case of primary disease, therefore the many emphasis of ministerial drug taking a tonic or nourishing food to build up one's health for kidney.Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, can promote the recovery of blood vessel, Hirudo dissipating blood stasis to promote menstruationg, Oletum Trogopterori promoting blood circulation to remove blood stasis, Olibanum, Myrrha promoting blood circulation and stopping pain, detumescence and promoting granulation, be used for promoting the reparation of ulcer spot, Rhizoma Corydalis blood circulation promoting regulates qi, Radix Curcumae regulating qi to disperse stagnation, Rhizoma Phragmitis clearing away heat and promoting production of body fluid, Rhizoma Polygonati boosting qi and nourishing yin, spleen invigorating lung moistening, Rhizoma Imperatae cooling blood for hemostasis, Radix Puerariae induces sweat and brings down a fever, and above a few taste is ministerial drug altogether, Radix Glycyrrhizae priming is returned through, coordinating the actions of various ingredients in a prescription, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has effect of tonifying Qi and lifting yang, promoting diuresis to eliminate damp pathogen, liver and kidney tonifying, spleen invigorating mind calming, effectively can treat Wei lattice granuloma.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Astragali 25-35 part, Radix Codonopsis 10-20 part, Rhizoma Atractylodis Macrocephalae (parched) 15-25 part, Poria 10-20 part, Radix Paeoniae Alba (parched) 10-20 part, Radix Angelicae Sinensis 13-23 part, Radix Rhodiolae 13-23 part, Rhizoma Chuanxiong 10-20 part, Radix Salviae Miltiorrhizae 15-25 part, Semen Persicae (parched) 7-17 part, Flos Carthami 4-14 part, Radix Dipsaci 15-25 part, Cortex Eucommiae 13-23 part, Fructus Psoraleae 13-23 part, Ramulus Cinnamomi 7-17 part, Hirudo 3-9 part, Oletum Trogopterori 3-9 part, Olibanum 3-9 part, Myrrha 3-9 part, Rhizoma Corydalis 13-23 part, Radix Curcumae 10-20 part, Rhizoma Phragmitis 19-29 part, Rhizoma Polygonati 13-23 part, Rhizoma Imperatae 19-29 part, Radix Puerariae 10-20 part, Radix Glycyrrhizae 3-9 part.
Wherein be preferably: the Radix Astragali 30 parts, Radix Codonopsis 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 20 parts, 15 parts, Poria, Radix Paeoniae Alba (parched) 15 parts, Radix Angelicae Sinensis 18 parts, Radix Rhodiolae 18 parts, Rhizoma Chuanxiong 15 parts, Radix Salviae Miltiorrhizae 20 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Radix Dipsaci 20 parts, the Cortex Eucommiae 18 parts, Fructus Psoraleae 18 parts, Ramulus Cinnamomi 12 parts, Hirudo 6 parts, Oletum Trogopterori 6 parts, Olibanum 6 parts, Myrrha 6 parts, Rhizoma Corydalis 18 parts, Radix Curcumae 15 parts, Rhizoma Phragmitis 24 parts, Rhizoma Polygonati 18 parts, Rhizoma Imperatae 24 parts, Radix Puerariae 15 parts, Radix Glycyrrhizae 6 parts.
Medicine of the present invention can adopt the conventional fabrication process of Chinese medicine preparation, can be made into said dosage form on any one pharmaceutics, as pill, powder, tablet, capsule, granule, syrup, oral liquid etc.Such as these crude drug grind into fine powder mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.
The preferred preparation method of the present invention is pill, and its preparation method is as follows:
Step one: by weight proportion of the present invention, take the Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Radix Paeoniae Alba (parched), Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Dipsaci, the Cortex Eucommiae, Radix Curcumae, Rhizoma Phragmitis, Rhizoma Polygonati, Rhizoma Imperatae, Radix Puerariae is put into marmite and is added cold water, exceed powder 3-4 centimetre, after being fried boiling with high heat, again with 20-30 minute at a simmer, filter, obtain filtrate, the water of 3-4 centimetre is added in residue medicinal residues, then Poria is added, Radix Rhodiolae, Fructus Psoraleae, Ramulus Cinnamomi, Oletum Trogopterori, Olibanum, Myrrha decocts 20 minutes together, finally add Flos Carthami, Radix Glycyrrhizae decocts 10 minutes, filter, obtain filtrate, merge twice filtrate, for subsequent use,
Step 2: by weight proportion of the present invention, take Semen Persicae (parched), Hirudo grinds, crosses 180 mesh sieves, for subsequent use;
Step 3: concentrated by the medicinal liquid in step one, when filtrate is concentrated into 75 DEG C-85 DEG C, adds 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, the thick paste of relative density 1.15 ~ 1.20 under 75 DEG C of environment, then by the medicated powder Homogeneous phase mixing in step 2 in thick paste, by air-dry for thick paste pulverizing, add Mel, antiseptic, wetting agent etc., carry out beating, rubbing, one-tenth ball, dry, be distributed into bag, both the granulomatous pill for the treatment of Wei lattice of the present invention.
Medicine of the present invention has the effects such as tonifying Qi and lifting yang, promoting diuresis to eliminate damp pathogen, liver and kidney tonifying, spleen invigorating mind calming, and curative effect is obvious, side effect is little, taking convenience, cheap, not easily recur, add up according to clinical 26 routine patient view, use specific embodiment of the invention medicine one the total effective rate course for the treatment of 80.8%, two the total effective rate course for the treatment of 92.3%.
Detailed description of the invention
Embodiment one, the Radix Astragali 25 parts, Radix Codonopsis 10 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, 10 parts, Poria, Radix Paeoniae Alba (parched) 10 parts, Radix Angelicae Sinensis 13 parts, Radix Rhodiolae 13 parts, Rhizoma Chuanxiong 10 parts, Radix Salviae Miltiorrhizae 15 parts, Semen Persicae (parched) 7 parts, 4 parts, Flos Carthami, Radix Dipsaci 15 parts, the Cortex Eucommiae 13 parts, Fructus Psoraleae 13 parts, Ramulus Cinnamomi 7 parts, Hirudo 3 parts, Oletum Trogopterori 3 parts, Olibanum 3 parts, Myrrha 3 parts, Rhizoma Corydalis 13 parts, Radix Curcumae 10 parts, Rhizoma Phragmitis 19 parts, Rhizoma Polygonati 13 parts, Rhizoma Imperatae 19 parts, Radix Puerariae 10 parts, Radix Glycyrrhizae 3 parts.
Embodiment two, the Radix Astragali 30 parts, Radix Codonopsis 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 20 parts, 15 parts, Poria, Radix Paeoniae Alba (parched) 15 parts, Radix Angelicae Sinensis 18 parts, Radix Rhodiolae 18 parts, Rhizoma Chuanxiong 15 parts, Radix Salviae Miltiorrhizae 20 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Radix Dipsaci 20 parts, the Cortex Eucommiae 18 parts, Fructus Psoraleae 18 parts, Ramulus Cinnamomi 12 parts, Hirudo 6 parts, Oletum Trogopterori 6 parts, Olibanum 6 parts, Myrrha 6 parts, Rhizoma Corydalis 18 parts, Radix Curcumae 15 parts, Rhizoma Phragmitis 24 parts, Rhizoma Polygonati 18 parts, Rhizoma Imperatae 24 parts, Radix Puerariae 15 parts, Radix Glycyrrhizae 6 parts.
Embodiment three, the Radix Astragali 35 parts, Radix Codonopsis 20 parts, Rhizoma Atractylodis Macrocephalae (parched) 25 parts, 20 parts, Poria, Radix Paeoniae Alba (parched) 20 parts, Radix Angelicae Sinensis 23 parts, Radix Rhodiolae 23 parts, Rhizoma Chuanxiong 20 parts, Radix Salviae Miltiorrhizae 25 parts, Semen Persicae (parched) 17 parts, 14 parts, Flos Carthami, Radix Dipsaci 25 parts, the Cortex Eucommiae 23 parts, Fructus Psoraleae 23 parts, Ramulus Cinnamomi 17 parts, Hirudo 9 parts, Oletum Trogopterori 9 parts, Olibanum 9 parts, Myrrha 9 parts, Rhizoma Corydalis 23 parts, Radix Curcumae 20 parts, Rhizoma Phragmitis 29 parts, Rhizoma Polygonati 23 parts, Rhizoma Imperatae 29 parts, Radix Puerariae 20 parts, Radix Glycyrrhizae 9 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Accept patient's totally 26 examples for medical treatment, patient age 30-50 year, male 16 example, women 10 example, M-F is 1.6:1, and the course of disease time, not etc. every basic documents such as patient age, sex, the course of disease were substantially not identical.
Two, diagnostic criteria
Nineteen ninety American Rheumatism Association propose standard can be for reference:
1, nose or stomatitis (pain or Silent Neuritis oral ulcer, courageous and upright nasal discharge);
2, rabat shows that tuberosity, stationarity lung infiltrate or cavity is formed;
3, urine microscopic hematuria (erythrocyte > 5/ high power field) or red cell cast;
4, plug is organized to show around arterial wall or tremulous pulse and small artery and tissue has granulomatous inflammation to change.Meet above-mentioned more than 2 or 2 standards, diagnosable is Witt theorem.
Three, Therapeutic Method
According to Medications Example two of the present invention, and the pill that preferred preparation method is made, warm water takes, every day 3 times, each 3-5 grain, within 10 days, is a course for the treatment of.
Four, efficacy assessment standard
Effective: patient is after treatment, and its symptom and every sign all disappear, pathological tissues place granulomatous inflammation disappears;
Effective: patient its symptom and every sign after treatment all obviously alleviate, the lesion Tissue Granulation inflammation that swells is controlled;
Invalid: to be not improved after patient treatment.
Five, therapeutic outcome statistics
Wherein: total effective rate=obvious effective rate+effective percentage
Shown by the statistics of therapeutic outcome, Chinese medicine of the present invention has good clinical effectiveness in control and treatment Wei lattice granuloma, is worth promoting in clinical practice.
Model case and curative effect:
Zhang, man, 44 years old, patient suffers from sinusitis, recent about 2 months, headache always, nasal obstruction, sometimes with the symptom of heating, generate heat irregular, there is expectoration phenomenon, there is little pimple in shirtfront simultaneously, red, patient goes to hospital to check, nasal cavity has courageous and upright secretions, there is cavitation in pulmonary, it is early stage that pathological biopsy is diagnosed as Witt theorem, do not involve kidney, patient takes Chinese medicine embodiment two of the present invention, and the pill made of preferred preparation method, patient's headache after two courses for the treatment of, the phenomenon of the little pimple of health is eased, fever phenomenon disappears, patient continues to take three courses for the treatment of, uncomfortable anesthesia, patient goes to hospital to check, pathological biopsy is not tested with Witt theorem, and entire patient is checked, lungs, kidney is also all basic recovers normal, follow up a case by regular visits to half a year, do not recur.
Claims (4)
1. the granulomatous Chinese medicine preparation for the treatment of Wei lattice, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Astragali 25-35 part, Radix Codonopsis 10-20 part, Rhizoma Atractylodis Macrocephalae (parched) 15-25 part, Poria 10-20 part, Radix Paeoniae Alba (parched) 10-20 part, Radix Angelicae Sinensis 13-23 part, Radix Rhodiolae 13-23 part, Rhizoma Chuanxiong 10-20 part, Radix Salviae Miltiorrhizae 15-25 part, Semen Persicae (parched) 7-17 part, Flos Carthami 4-14 part, Radix Dipsaci 15-25 part, Cortex Eucommiae 13-23 part, Fructus Psoraleae 13-23 part, Ramulus Cinnamomi 7-17 part, Hirudo 3-9 part, Oletum Trogopterori 3-9 part, Olibanum 3-9 part, Myrrha 3-9 part, Rhizoma Corydalis 13-23 part, Radix Curcumae 10-20 part, Rhizoma Phragmitis 19-29 part, Rhizoma Polygonati 13-23 part, Rhizoma Imperatae 19-29 part, Radix Puerariae 10-20 part, Radix Glycyrrhizae 3-9 part.
2. the granulomatous Chinese medicine preparation for the treatment of Wei lattice according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: the Radix Astragali 30 parts, Radix Codonopsis 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 20 parts, 15 parts, Poria, Radix Paeoniae Alba (parched) 15 parts, Radix Angelicae Sinensis 18 parts, Radix Rhodiolae 18 parts, Rhizoma Chuanxiong 15 parts, Radix Salviae Miltiorrhizae 20 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Radix Dipsaci 20 parts, the Cortex Eucommiae 18 parts, Fructus Psoraleae 18 parts, Ramulus Cinnamomi 12 parts, Hirudo 6 parts, Oletum Trogopterori 6 parts, Olibanum 6 parts, Myrrha 6 parts, Rhizoma Corydalis 18 parts, Radix Curcumae 15 parts, Rhizoma Phragmitis 24 parts, Rhizoma Polygonati 18 parts, Rhizoma Imperatae 24 parts, Radix Puerariae 15 parts, Radix Glycyrrhizae 6 parts.
3. one according to claim 1 and 2 treats the granulomatous Chinese medicine preparation of Wei lattice, it is characterized in that: described Chinese medicine preparation is pill.
4. treat the preparation method of the granulomatous Chinese medicine preparation of Wei lattice for one kind, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, take the Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Radix Paeoniae Alba (parched), Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Dipsaci, the Cortex Eucommiae, Radix Curcumae, Rhizoma Phragmitis, Rhizoma Polygonati, Rhizoma Imperatae, Radix Puerariae is put into marmite and is added cold water, exceed powder 3-4 centimetre, after being fried boiling with high heat, again with 20-30 minute at a simmer, filter, obtain filtrate, the water of 3-4 centimetre is added in residue medicinal residues, then Poria is added, Radix Rhodiolae, Fructus Psoraleae, Ramulus Cinnamomi, Oletum Trogopterori, Olibanum, Myrrha decocts 20 minutes together, finally add Flos Carthami, Radix Glycyrrhizae decocts 10 minutes, filter, obtain filtrate, merge twice filtrate, for subsequent use, step 2: by weight proportion of the present invention, take Semen Persicae (parched), Hirudo grinds, crosses 180 mesh sieves, for subsequent use, step 3: concentrated by the medicinal liquid in step one, when filtrate is concentrated into 75 DEG C-85 DEG C, adds 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, the thick paste of relative density 1.15 ~ 1.20 under 75 DEG C of environment, then by the medicated powder Homogeneous phase mixing in step 2 in thick paste, by air-dry for thick paste pulverizing, add Mel, antiseptic, wetting agent etc., carry out beating, rubbing, one-tenth ball, dry, be distributed into bag, both the granulomatous pill for the treatment of Wei lattice of the present invention.
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| CN105999044A (en) * | 2016-07-16 | 2016-10-12 | 乔海燕 | Medicine for treating infantile sarcoidosis and preparation method thereof |
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| CN105999044A (en) * | 2016-07-16 | 2016-10-12 | 乔海燕 | Medicine for treating infantile sarcoidosis and preparation method thereof |
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