CN103919913A - Medicine for treating Wegner granulomatosis with pulmonary symptoms as first clinical manifestation and preparation method of medicine - Google Patents
Medicine for treating Wegner granulomatosis with pulmonary symptoms as first clinical manifestation and preparation method of medicine Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines and particularly relates to a medicine for treating Wegner granulomatosis with pulmonary symptoms as first clinical manifestation and a preparation method of the medicine. The medicine for treating Wegner granulomatosis with pulmonary symptoms as first clinical manifestation is prepared from the following traditional Chinese medicine raw materials in parts by weight: 80-120 parts of angelica sinensis, 40-60 parts of liquorice, 130-170 parts of double blossoms, 130-170 parts of radix scrophulariae, 16-24 parts of gypsum and 40-60 parts of platycodon grandiflorum. The total effective rate of the medicine for treating Wegner granulomatosis with pulmonary symptoms as first clinical manifestation reaches up to 85.71%.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of medicine and preparation method thereof that lung symptoms is the Wegner granulomatosis of First presentation for the treatment of.
Background technology
Wegner granulomatosis (wegener ' s granulometosis, WG) be a kind of granuloma gangraenescens inflammatory diseases of agnogenic middle or small blood vessel, mainly involve lower respiratory tract and kidney, clinical manifestation is the comprehensive syndrome that whole body is organized more, many internal organs are impaired, pulmonary gets involved approximately 80%, its clinical symptoms and other pulmonary disease are distinguished without specificity, and the case that the lung symptoms of especially take is First presentation is easily by mistaken diagnosis, thereby delay its diagnosis and treatment.
Having not yet to see report has the medicine of the Wegner granulomatosis of being exclusively used in.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of medicine and preparation method thereof that lung symptoms is the Wegner granulomatosis of First presentation for the treatment of.
The present invention realizes by following technical scheme:
Treat the medicine that lung symptoms is the Wegner granulomatosis of First presentation, by the raw material of Chinese medicine medicine of following weight portion, formed: Radix Angelicae Sinensis 80-120 part, Radix Glycyrrhizae 40-60 part, Flos Lonicerae 130-170 part, Radix Scrophulariae 130-170 part, Gypsum Fibrosum 16-24 part, Radix Platycodonis 40-60 part.
Preferably, the medicine of the Wegner granulomatosis that above-mentioned treatment lung symptoms is First presentation, is comprised of the raw material of Chinese medicine medicine of following weight portion: Radix Angelicae Sinensis 90-100 part, Radix Glycyrrhizae 45-55 part, Flos Lonicerae 140-160 part, Radix Scrophulariae 140-160 part, Gypsum Fibrosum 18-22 part, Radix Platycodonis 45-55 part.
Preferred, the medicine of the Wegner granulomatosis that above-mentioned treatment lung symptoms is First presentation, is comprised of the raw material of Chinese medicine medicine of following weight portion:
100 parts of Radix Angelicae Sinensis, 50 parts, Radix Glycyrrhizae, 150 parts of Flos Loniceraes, 150 parts of Radix Scrophulariae, 20 parts, Gypsum Fibrosum, 50 parts of Radix Platycodoniss.
The medicine of the Wegner granulomatosis that above-mentioned treatment lung symptoms is First presentation, the dosage form of this medicine is oral formulations.
Preferably, the medicine of the Wegner granulomatosis that above-mentioned treatment lung symptoms is First presentation, the dosage form of this medicine is granule.
Preferably, the medicine of the Wegner granulomatosis that above-mentioned treatment lung symptoms is First presentation, the dosage form of this medicine is unguentum.
The preparation method of the medicine of the Wegner granulomatosis that above-mentioned treatment lung symptoms is First presentation, comprises the steps:
A. by Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Scrophulariae, Gypsum Fibrosum, Radix Platycodonis, decoct with water extraction secondary, add for the first time injection volume 4-6 times of water gaging and decoct 1.5-2.5 hour, add for the second time injection volume 2-4 times of water gaging and decoct 1-2 hour, collecting decoction, filters; It is 1.22～1.26 concentrated solution that 60 ℃ of filtrates are concentrated into relative density, lets cool, and adds ethanol to reaching 80% containing alcohol amount, stirs evenly, and standing 12 hours of room temperature, filters; 60 ℃ of filtrates are reclaimed ethanol and are concentrated into relative density is 1.35～1.38 thick paste;
B. thick paste step a being made adds pharmaceutically acceptable adjuvant to make pharmaceutical preparation.
Preferably, the preparation method of the medicine of the Wegner granulomatosis that above-mentioned treatment lung symptoms is First presentation, in described step a, amount of water is injection volume 5 times for the first time, decocts 2 hours; Amount of water is injection volume 3 times for the second time, decocts 1 hour.
The acceptable carrier of described medicine is selected from: Mel, refined honey, mannitol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, vitamin C, tie up main plain E, vitamin D, azone, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, polysorbate60-80, span-80, Cera Flava, lanoline, liquid paraffin, hexadecanol, gallate ester, fine jade, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
The traditional Chinese medical science thinks that pyretic toxicity blood stasis resistance network is the basic pathogenesis of Wegner granulomatosis.Control suitable heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.In drug prescription of the present invention, Flos Lonicerae is sweet trembles with fear into the heart, is good at heat-clearing and toxic substances removing, therefore reuse as principal agent, Radix Angelicae Sinensis promoting blood circulation to remove blood stasis, Radix Scrophulariae eliminating fire and detoxication, Radix Glycyrrhizae removing summer-heat hundred poison, the heat of Gypsum Fibrosum removing summer-heat lung stomach, join Flos Lonicerae to strengthen the power of heat-clearing and toxic substances removing, altogether for assisting a ruler in governing a country, Radix Platycodonis lung qi dispersing is regulated the flow of vital energy, for making medicine, draw all medicines and enter lung.All medicines share, can heat-clearing and toxic substances removing, again can promoting blood circulation to remove blood stasis, and be the good recipe of the treatment lung symptoms Wegner granulomatosis that is First presentation.
Modern pharmacological research confirms, originally can dredge and blood circulation promoting, not inaccessible tremulous pulse and side Zhi Xunhuan are improved, thereby mitigation symptoms avoids angionecrosis to proceed; According to angiography, prove, some cases likely makes inaccessible blood vessel recover dredging.We still have anti-inflammation, antalgic and sedative, detumescence and bring down a fever, promote the effects such as ulcer healing.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Radix Angelicae Sinensis 1000g, Radix Glycyrrhizae 500g, Flos Lonicerae 1500g, Radix Scrophulariae 1500g, Gypsum Fibrosum 200g, Radix Platycodonis 500g.
Preparation method:
A. by Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Scrophulariae, Gypsum Fibrosum, Radix Platycodonis, decoct with water extraction secondary, add for the first time 5 times of water gagings of injection volume and decoct 2 hours, add for the second time 3 times of water gagings of injection volume and decoct 1.5 hours, collecting decoction, filters; It is 1.22～1.26 concentrated solution that 60 ℃ of filtrates are concentrated into relative density, lets cool, and adds ethanol to reaching 80% containing alcohol amount, stirs evenly, and standing 12 hours of room temperature, filters; 60 ℃ of filtrates are reclaimed ethanol and are concentrated into relative density is 1.35～1.38 thick paste;
B. thick paste step a being made adds Mel and water to make unguentum, prepares altogether 1000g.
Usage and dosage a: 50g, 2-3 time on the one 10 days was 1 course for the treatment of.
Embodiment 2
Radix Angelicae Sinensis 900g, Radix Glycyrrhizae 550g, Flos Lonicerae 1400g, Radix Scrophulariae 1600g, Gypsum Fibrosum 180g, Radix Platycodonis 550g.
Preparation method:
A. by Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Scrophulariae, Gypsum Fibrosum, Radix Platycodonis, decoct with water extraction secondary, add for the first time 4 times of water gagings of injection volume and decoct 1.5 hours, add for the second time 2 times of water gagings of injection volume and decoct 1 hour, collecting decoction, filters; It is 1.22～1.26 concentrated solution that 60 ℃ of filtrates are concentrated into relative density, lets cool, and adds ethanol to reaching 80% containing alcohol amount, stirs evenly, and standing 12 hours of room temperature, filters; 60 ℃ of filtrates are reclaimed ethanol and are concentrated into relative density is 1.35～1.38 thick paste;
B. thick paste step a being made adds Mel and the agent of water granulation, prepares altogether 1000g.
Usage and dosage a: 50g, 2-3 time on the one 10 days was 1 course for the treatment of.
Embodiment 3
Radix Angelicae Sinensis 1000g, Radix Glycyrrhizae 450g, Flos Lonicerae 1600g, Radix Scrophulariae 1400g, Gypsum Fibrosum 220g, Radix Platycodonis 450g.
Preparation method:
A. by Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Scrophulariae, Gypsum Fibrosum, Radix Platycodonis, decoct with water extraction secondary, add for the first time 6 times of water gagings of injection volume and decoct 2.5 hours, add for the second time 5 times of water gagings of injection volume and decoct 2 hours, collecting decoction, filters; It is 1.22～1.26 concentrated solution that 60 ℃ of filtrates are concentrated into relative density, lets cool, and adds ethanol to reaching 80% containing alcohol amount, stirs evenly, and standing 12 hours of room temperature, filters; 60 ℃ of filtrates are reclaimed ethanol and are concentrated into relative density is 1.35～1.38 thick paste;
B. thick paste step a being made adds Mel and water to make unguentum, prepares altogether 1000g.
Usage and dosage a: 50g, 2-3 time on the one 10 days was 1 course for the treatment of.
Embodiment 4
Radix Angelicae Sinensis 800g, Radix Glycyrrhizae 600g, Flos Lonicerae 1300g, Radix Scrophulariae 1700g, Gypsum Fibrosum 160g, Radix Platycodonis 600g.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 5
Radix Angelicae Sinensis 1200g, Radix Glycyrrhizae 400g, Flos Lonicerae 1700g, Radix Scrophulariae 1300g, Gypsum Fibrosum 240g, Radix Platycodonis 400g.
Preparation method and usage and dosage are with embodiment 1.
The preparation of embodiments of the invention l has been carried out to clinical pharmacodynamics test, and result is as follows:
1 data and method
1.1 physical data
28 examples are inpatient, and diagnosis all meets the Wegner granulomatosis criteria for classification [3] of Americanism damp disease association in 1990, male 16 examples, female's 12 examples, at 20～68 years old age, average 35 years old, all take lung symptoms as First presentation is medical and repeatedly show effect Multiple Hospitalization treatment after alleviation.
1.2 clinical manifestation
Starting lung symptoms has heating 20 examples, cough, purulent sputum 16 examples, cough, bloody sputum 12 examples, uncomfortable in chest, tachypnea, dyspnea 2 examples, symptom is involved the multisystems such as ear, nose, larynx, kidney gradually, occurs rhinitis 16 examples, pharyngolaryngitis 20 examples, kidney damage 12 examples, nervous system damage 4 examples.
2 Therapeutic Method: adopt the unguentum of embodiment 1 preparation, each 50ml, every day 2 times, 10 days is a course for the treatment of.Observing effect after 1 course for the treatment of.
3 criterions of therapeutical effect: cure: fever and cough purulent sputum and bloody sputum disappear, uncomfortable in chest, tachypnea, dyspnea disappear, secondary transference cure; Take a turn for the better, uncomfortable in chest, tachypnea, dyspnea disappear, and still have fever and cough symptom, and secondary disease disappears; Invalid: symptom has no improvement.Nonresponder turns hormone therapy.
4 results
28 routine patients all treat after making a definite diagnosis, and 8 examples are cured, and 16 examples take a turn for the better, and 4 examples are invalid, total effective rate 85.71%.
Claims (8)
1. treat the medicine that lung symptoms is the Wegner granulomatosis of First presentation, by the raw material of Chinese medicine medicine of following weight portion, formed:
Radix Angelicae Sinensis 80-120 part, Radix Glycyrrhizae 40-60 part, Flos Lonicerae 130-170 part, Radix Scrophulariae 130-170 part, Gypsum Fibrosum 16-24 part, Radix Platycodonis 40-60 part.
2. the medicine of the Wegner granulomatosis that treatment lung symptoms according to claim 1 is First presentation, is characterized in that, the raw material of Chinese medicine medicine of following weight portion, consists of:
Radix Angelicae Sinensis 90-100 part, Radix Glycyrrhizae 45-55 part, Flos Lonicerae 140-160 part, Radix Scrophulariae 140-160 part, Gypsum Fibrosum 18-22 part, Radix Platycodonis 45-55 part.
3. the medicine of the Wegner granulomatosis that treatment lung symptoms according to claim 3 is First presentation, is characterized in that, the raw material of Chinese medicine medicine of following weight portion, consists of:
100 parts of Radix Angelicae Sinensis, 50 parts, Radix Glycyrrhizae, 150 parts of Flos Loniceraes, 150 parts of Radix Scrophulariae, 20 parts, Gypsum Fibrosum, 50 parts of Radix Platycodoniss.
4. the medicine of the Wegner granulomatosis that is First presentation according to the treatment lung symptoms described in claim 1 or 2 or 3, is characterized in that, the dosage form of this medicine is oral formulations.
5. the medicine of the Wegner granulomatosis that treatment lung symptoms according to claim 4 is First presentation, is characterized in that, the dosage form of this medicine is granule.
6. the medicine of the Wegner granulomatosis that treatment lung symptoms according to claim 4 is First presentation, is characterized in that, the dosage form of this medicine is unguentum.
7. the preparation method of the medicine of the Wegner granulomatosis that the treatment lung symptoms described in claim 1 or 2 or 3 is First presentation, comprises the steps:
A. by Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Scrophulariae, Gypsum Fibrosum, Radix Platycodonis, decoct with water extraction secondary, add for the first time injection volume 4-6 times of water gaging and decoct 1.5-2.5 hour, add for the second time injection volume 2-4 times of water gaging and decoct 1-2 hour, collecting decoction, filters; It is 1.22～1.26 concentrated solution that 60 ℃ of filtrates are concentrated into relative density, lets cool, and adds ethanol to reaching 80% containing alcohol amount, stirs evenly, and standing 12 hours of room temperature, filters; 60 ℃ of filtrates are reclaimed ethanol and are concentrated into relative density is 1.35～1.38 thick paste;
B. thick paste step a being made adds pharmaceutically acceptable adjuvant to make pharmaceutical preparation.
8. the preparation method of the medicine of the Wegner granulomatosis that treatment lung symptoms according to claim 7 is First presentation, is characterized in that, in described step a, amount of water is injection volume 5 times for the first time, decocts 2 hours; Amount of water is injection volume 3 times for the second time, decocts 1 hour.
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| CN201410139673.5A CN103919913B (en) | 2014-04-09 | 2014-04-09 | A kind of lung symptoms for the treatment of is medicine of the Wegner granulomatosis of First presentation and preparation method thereof |
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| CN201410139673.5A CN103919913B (en) | 2014-04-09 | 2014-04-09 | A kind of lung symptoms for the treatment of is medicine of the Wegner granulomatosis of First presentation and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104689252A (en) * | 2015-03-30 | 2015-06-10 | 金新美 | Traditional Chinese preparation for treating Wegener granulomatosis and preparation method thereof |
| CN105168562A (en) * | 2015-10-26 | 2015-12-23 | 济南新时代医药科技有限公司 | Traditional Chinese medicine composition for treating wegener granulomatosis with pulmonary symptoms as first presentation and preparation method thereof |
-
2014
- 2014-04-09 CN CN201410139673.5A patent/CN103919913B/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 周彩云主编: "《房定亚治疗风湿病传真》", 31 August 2012, article "韦格纳肉芽肿", pages: 286-289 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104689252A (en) * | 2015-03-30 | 2015-06-10 | 金新美 | Traditional Chinese preparation for treating Wegener granulomatosis and preparation method thereof |
| CN105168562A (en) * | 2015-10-26 | 2015-12-23 | 济南新时代医药科技有限公司 | Traditional Chinese medicine composition for treating wegener granulomatosis with pulmonary symptoms as first presentation and preparation method thereof |
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| CN103919913B (en) | 2016-03-23 |
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Inventor after: Song Dehai Inventor after: Bian Ruimin Inventor after: Wang Bin Inventor after: Man Yuqing Inventor after: Gao Xinfu Inventor after: Shi Xiaorong Inventor before: Man Yuqing Inventor before: Bian Ruimin Inventor before: Wang Bin Inventor before: Shi Xiaorong Inventor before: Gao Xinfu |
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Granted publication date: 20160323 Termination date: 20170409 |