CN103768308B - A kind of pharmaceutical composition that is used for the treatment of the infection of the upper respiratory tract and preparation method thereof - Google Patents
A kind of pharmaceutical composition that is used for the treatment of the infection of the upper respiratory tract and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical composition that is used for the treatment of the infection of the upper respiratory tract and preparation method thereof, belong to Chinese medicine preparation technical scheme. Include following raw material by weight: 40～50 parts, Chinese ephedra, 20～30 parts, Radix Glycyrrhizae, 20～40 parts of Radix Isatidis, 10～20 parts of radix bupleuri, 5～10 parts of the tuber of pinellia, 5～10 parts of the roots of large-flowered skullcap, 10～20 parts of dandelions, 5～10 parts of dried orange peels, 3～5 parts of balloonflower roots, 4～8 parts of menthols, windproof 3～5 parts, 6～12 parts of the capsules of weeping forsythia, 10～15 parts of datura flowers, 10～15 parts of semen brassicaes, 30～50 parts, dextrin. The present invention acts synergistically by each herbal medicine, can effectively treat the infection of the upper respiratory tract, and alleviate malaise symptoms; Meanwhile, by the tuber of pinellia is separately extracted, effectively improve the extract yield of ephedrine, menthol has been processed by milipore filter, removed impurity, improved significantly the stability of finished product Ephedrine.
Description
Technical field
The invention discloses a kind of pharmaceutical composition that is used for the treatment of the infection of the upper respiratory tract and preparation method thereof, belong to Chinese medicinePreparation technique scheme.
Background technology
The infection of the upper respiratory tract refers to from nasal cavity to the acutely inflamed general name between throat, is modal infectious diseaseSick. How to be caused by virus, after bacterium infects and is often secondary to virus infections. These disease four seasons, any age all can fall ill, by containingThe virulent spittle, droplet, or propagate through the apparatus polluting. Motherland's medical science is to infectious disease, particularly to respiratory tract infectionSick understanding and prevent and treat with a long history. Before more than 2,000 years, Han dynasty Zhang Zhongjing just has relevant discussion to go out side by side the side's of control medicine.
Although it is of a great variety to treat in the market the Chinese patent drug of infection of the upper respiratory tract disease, exist such as dosageShort, the inapparent problem of curative effect of the term of validity greatly.
Summary of the invention
The object of the invention is: a kind of Chinese medicine composition that is used for the treatment of the infection of the upper respiratory tract is provided. Technical scheme is:
Be used for the treatment of a pharmaceutical composition for the infection of the upper respiratory tract, include following raw material by weight: Chinese ephedra40～50 parts, 20～30 parts, Radix Glycyrrhizae, 20～40 parts of Radix Isatidis, 10～20 parts of radix bupleuri, 5～10 parts of the tuber of pinellia, 5～10 parts of the roots of large-flowered skullcap, Pu10～20 parts of public English, 5～10 parts of dried orange peels, 3～5 parts of balloonflower roots, 4～8 parts of menthols, windproof 3～5 parts, 6～12 parts of the capsules of weeping forsythia, foreign goldenSpend 10～15 parts, 10～15 parts of semen brassicaes, 30～50 parts, dextrin.
Chinese ephedra has relievings asthma, and antibechic, removes phlegm, sweating, and diuresis, anti-inflammatory, antipyretic, the effect of excited maincenter.
Radix Glycyrrhizae is for asthma and cough. Can be alone, also can the application of compatibility other drug. As control damp-phlegm syndrome's erchen tang; ControlThe Linggan Wuwei Jiangxin Tang that cold productive cough is breathed heavily; Control the sangxing decoction of dry stool phlegm cough; Control heat poison and cause lung carbuncle and cough the balloonflower root of the stench phlegm of salivaSoup; Control Radix Glycyrrhizae rhizoma zingiberis soup of coughing saliva foam etc. The also Chang Peiwu application of another cough due to wind-heat evil, cough due to wind-cold evil, phlegm heat cough.
Radix Isatidis has heat-clearing, removing toxic substances, cool blood, effect of relieve sore throat.
Effect that radix bupleuri has comprises: 1. antipyretic, active ingredient: volatile oil (eugenol, acid, r-undecanoic acid lactone andTo methoxybenzene diketone), saikoside (sapogenin A). Effect: to typhoid fever, paratyphoid vaccine, Escherichia coli liquid, fermented milk,Due to yeast etc., heating has trivial solution heat effect; And can make animal normal body temperature decline. Saikosaponin decoction 2g/kg fills with to rabbitStomach, to all having obvious refrigeration function with the heating that vaccine and temperature thorn cause. 2. anti-inflammatory, active ingredient: saponin(e. Effect: to manyDue to kind proinflammatory agent, ankle-joint is swollen all has inhibitory action with desmoplastic inflammation. Saikosaponin saikoside 300mg/kg abdominal cavity notePenetrate, can suppress the rat paw edema that carrageenan, serotonin, histamine cause, suppress rat granuloma swollen, can make simultaneouslyAdrenal gland hypertrophy, atrophy of thymus gland; Inflammation-inhibiting is organized histamine release and leukoplania. 3. Promote immunity function, active ingredient:Bupleurum chinense polysaccharide. Effect: phagocytic function strengthens, Natural killer activity strengthens, and improves special viral antibody titre, improves and drenchesCling to thin dysuria with lower abdominal colic core rate, improve skin delayed hypersensitivity reaction.
The tuber of pinellia can be eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass. Control wet phlegm cold drink, vomiting, gastric disorder causing nausea, coughs that to breathe heavily phlegm many, chest diaphragmTurgor, coma due to blocking of the respiratory system headache, dizzy egersis. Outer subduing inflammation. Cough for phlegm more breathe heavily, phlegm and retained fluid is dizzyly throbbed with fear, interior phlegm is dizzy, vomiting gastric disorder causing nausea, chest gastral cavityRuffian is vexed, globus hysteriocus disease; Raw with controlling the swollen subcutaneous nodule of carbuncle outward. Pinellia is used for stopping nausea and vomiting by lowering the adverse flow of QI.
Root of large-flowered skullcap heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive, hypotensive. For damp-warm syndrome, the heat temperature evil of vomitting uncomfortable in chest, damp and hot ruffianFull, rush down dysentery, jaundice, cough with lung heat, high hot polydipsia, blood-head is told nosebleed, carbuncle sore tumefacting virus, fetal irritability.
Dandelion is clearing heat and detoxicating, diuresis dissipating bind. Control acute mastitis, adenolymphitis, scrofula, malignant boil carbuncle toxin, acute conjunctivaInflammation, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infections.
Dried orange peel regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm. For chest gastral cavity turgor, food is few vomits and diarrhoea, coughing with a lot of sputum.
The functions such as balloonflower root has a surname's lung, eliminates the phlegm, relieve sore throat, apocenosis, cure mainly the symptom such as coughing with a lot of sputum, abscess of throat.
Peppermint brain-capacity optionally stimulates the frigidoreceptor of human body skin or mucous membrane, produces sense of cold reflection and creeping chill, drawsPlay skin and mucosa vessel retraction (in fact skin keeps normal); Also can cause contraction to the blood vessel of deep tissue in addition, and produceRaw therapeutic action. External application can anti-inflammatory, and pain relieving is antipruritic, stimulates circulation, and alleviates edema etc.; For oral administration with can in compound preparationAlleviate local inflammation (sphagitis) and treatment flu, and have stomach invigorating, wind dispelling effect.
Windproofly expel pathogenic wind from the body surface, removing dampness to relieve pain, spasmolysis, antipruritic. Cure mainly: catch cold; Headache bodily pain; Arthralgia due to wind-dampness; JointAche; Stomachache is had loose bowels; Discharging fresh blood stool; Lockjaw; Rubella itch; Sore from the beginning of.
The pharmacological action such as that the capsule of weeping forsythia capsule of weeping forsythia has is antibacterial, cardiac stimulant, diuresis, town are told is clearing heat and detoxicating Chinese medicine, at the beginning of curing mainly pyreticosisPlay the symptoms such as anemopyretic cold, heating, vexed, abscess of throat, acute nephritis, carbuncle sore tumefacting virus, its bacteriostasis and honeysuckle cardinal principleSimilar.
Datura flower antiasthmatic-antitussive; Narcotic analgesic; Spasmolysis is only jerked. For asthma and cough; Coldness and pain in the epigastrium; Arthralgia due to wind-dampness; Epilepsy;Infantile convulsion; Surgical anesthesia.
The open-minded phlegm profit of semen brassicae temperature lung gas, mammary gland dissipating bind is removed obstruction in channels to relieve pain. Cough for cold asthma due to excessive phlegm, distending pain in the chest and hypochondrium, the stagnant channels and collaterals of phlegm, closeJoint is numb, pain, phlegm-damp oozing in the body, cloudy subcutaneous ulcer pyogenic infections.
Another object of the present invention has been to provide a kind of above-mentioned pharmaceutical composition that is used for the treatment of the infection of the upper respiratory tractPreparation method, comprises the steps:
The 1st step, get Chinese ephedra, Radix Glycyrrhizae, Radix Isatidis, radix bupleuri, the root of large-flowered skullcap, dandelion, dried orange peel, balloonflower root, windproof, the capsule of weeping forsythia, datura flower,Semen brassicae, adds the ethanol water of 10～12 times of above medicinal material gross weights, decocts 2～4 hours, after elimination residue, by decocting liquidReclaim ethanol, obtain thick paste;
The 2nd step, get the tuber of pinellia, add the water of 8～10 times of tuber of pinellia weight, decoct 1～3 hour, elimination residue, obtains lixiviateLiquid;
The 3rd step, get menthol, add the water of 8～10 times of menthol weight, decoct 0.5～1 hour, elimination residue, will carryGet liquid and send into milipore filter and filter, obtain ultrafiltrate;
The 4th step, thick paste, leaching liquor, ultrafiltrate are merged, stir, be evaporated to the relative density at 80 DEG CIt is 1.25～1.39 extract;
The 5th step, extract is mixed with dextrin, granulate, dry, make.
In the 1st described step, the shared volume ratio of ethanol of ethanol water is 40%～50%.
The molecular cut off optimum of described milipore filter is 200,000～400,000.
In the 5th described step, granulation is to pass through wet granulation.
Beneficial effect
The present invention acts synergistically by each herbal medicine, can effectively treat the infection of the upper respiratory tract, and alleviates uncomfortable diseaseShape; Meanwhile, by the tuber of pinellia is separately extracted, effectively improve the extract yield of ephedrine, menthol has been entered by milipore filterRow is processed, and has removed impurity, has improved significantly the stability of finished product Ephedrine.
Detailed description of the invention
Embodiment 1
Be used for the treatment of a pharmaceutical composition for the infection of the upper respiratory tract, include following raw material: Chinese ephedra 40kg, Radix Glycyrrhizae20kg, Radix Isatidis 20kg, radix bupleuri 10kg, tuber of pinellia 5kg, root of large-flowered skullcap 5kg, dandelion 10kg, dried orange peel 5kg, balloonflower root 3kg, menthol4kg, windproof 3kg, capsule of weeping forsythia 6kg, datura flower 10kg, semen brassicae 10kg, dextrin 30kg.
Preparation method is:
The 1st step, get Chinese ephedra, Radix Glycyrrhizae, Radix Isatidis, radix bupleuri, the root of large-flowered skullcap, dandelion, dried orange peel, balloonflower root, windproof, the capsule of weeping forsythia, datura flower,Semen brassicae, adds the ethanol water (the shared volume ratio of ethanol of ethanol water is 40%) of 10 times of above medicinal material gross weights,Decoct 2 hours, after elimination residue, decocting liquid is reclaimed to ethanol, obtain thick paste;
The 2nd step, get the tuber of pinellia, add the water of 8 times of tuber of pinellia weight, decoct 1 hour, elimination residue, obtains leaching liquor;
The 3rd step, get menthol, add the water of 8 times of menthol weight, decoct 0.5 hour, elimination residue, send extractEnter milipore filter and filter (molecular cut off of milipore filter is 200,000), obtain ultrafiltrate;
The 4th step, thick paste, leaching liquor, ultrafiltrate are merged, stir, be evaporated to the relative density at 80 DEG CIt is 1.25 extract;
The 5th step, extract is mixed with dextrin, wet granulation, dry, make.
Embodiment 2
Be used for the treatment of a pharmaceutical composition for the infection of the upper respiratory tract, include following raw material: Chinese ephedra 50kg, Radix Glycyrrhizae30kg, Radix Isatidis 40kg, radix bupleuri 20kg, tuber of pinellia 10kg, root of large-flowered skullcap 10kg, dandelion 20kg, dried orange peel 10kg, balloonflower root 5kg, menthol8kg, windproof 5kg, capsule of weeping forsythia 12kg, datura flower 15kg, semen brassicae 15kg, dextrin 50kg.
Preparation method is:
The 1st step, get Chinese ephedra, Radix Glycyrrhizae, Radix Isatidis, radix bupleuri, the root of large-flowered skullcap, dandelion, dried orange peel, balloonflower root, windproof, the capsule of weeping forsythia, datura flower,Semen brassicae, adds the ethanol water (the shared volume ratio of ethanol of ethanol water is 50%) of 12 times of above medicinal material gross weights,Decoct 4 hours, after elimination residue, decocting liquid is reclaimed to ethanol, obtain thick paste;
The 2nd step, get the tuber of pinellia, add the water of 10 times of tuber of pinellia weight, decoct 3 hours, elimination residue, obtains leaching liquor;
The 3rd step, get menthol, add the water of 10 times of menthol weight, decoct 1 hour, elimination residue, sends into extractMilipore filter filters (molecular cut off of milipore filter is 400,000), obtains ultrafiltrate;
The 4th step, thick paste, leaching liquor, ultrafiltrate are merged, stir, be evaporated to the relative density at 80 DEG CIt is 1.39 extract;
The 5th step, extract is mixed with dextrin, wet granulation, dry, make.
Embodiment 3
Be used for the treatment of a pharmaceutical composition for the infection of the upper respiratory tract, include following raw material: Chinese ephedra 45kg, Radix Glycyrrhizae25kg, Radix Isatidis 30kg, radix bupleuri 15kg, tuber of pinellia 7kg, root of large-flowered skullcap 7kg, dandelion 15kg, dried orange peel 7kg, balloonflower root 4kg, menthol6kg, windproof 4kg, capsule of weeping forsythia 8kg, datura flower 12kg, semen brassicae 12kg, DEXTRIN kg.
Preparation method is:
The 1st step, get Chinese ephedra, Radix Glycyrrhizae, Radix Isatidis, radix bupleuri, the root of large-flowered skullcap, dandelion, dried orange peel, balloonflower root, windproof, the capsule of weeping forsythia, datura flower,Semen brassicae, adds the ethanol water (the shared volume ratio of ethanol of ethanol water is 45%) of 11 times of above medicinal material gross weights,Decoct 3 hours, after elimination residue, decocting liquid is reclaimed to ethanol, obtain thick paste;
The 2nd step, get the tuber of pinellia, add the water of 9 times of tuber of pinellia weight, decoct 2 hours, elimination residue, obtains leaching liquor;
The 3rd step, get menthol, add the water of 9 times of menthol weight, decoct 0.7 hour, elimination residue, send extractEnter milipore filter and filter (molecular cut off of milipore filter is 300,000), obtain ultrafiltrate;
The 4th step, thick paste, leaching liquor, ultrafiltrate are merged, stir, be evaporated to the relative density at 80 DEG CIt is 1.30 extract;
The 5th step, extract is mixed with dextrin, wet granulation, dry, make.
Reference examples 1
Reference examples 1 is with the difference of embodiment 3: the tuber of pinellia extracts with other raw material in the 1st step simultaneously, concrete andSay as follows:
Be used for the treatment of a pharmaceutical composition for the infection of the upper respiratory tract, include following raw material: Chinese ephedra 45kg, Radix Glycyrrhizae25kg, Radix Isatidis 30kg, radix bupleuri 15kg, tuber of pinellia 7kg, root of large-flowered skullcap 7kg, dandelion 15kg, dried orange peel 7kg, balloonflower root 4kg, menthol6kg, windproof 4kg, capsule of weeping forsythia 8kg, datura flower 12kg, semen brassicae 12kg, DEXTRIN kg.
Preparation method is:
The 1st step, get Chinese ephedra, Radix Glycyrrhizae, Radix Isatidis, radix bupleuri, the root of large-flowered skullcap, dandelion, dried orange peel, balloonflower root, windproof, the capsule of weeping forsythia, datura flower,Semen brassicae, the tuber of pinellia, (the shared volume ratio of ethanol of ethanol water is to add the ethanol water of 11 times of above medicinal material gross weights45%), decoct 3 hours, after elimination residue, decocting liquid is reclaimed to ethanol, obtain thick paste;
The 2nd step, get menthol, add the water of 9 times of menthol weight, decoct 0.7 hour, elimination residue, send extractEnter milipore filter and filter (molecular cut off of milipore filter is 300,000), obtain ultrafiltrate;
The 3rd step, thick paste, ultrafiltrate are merged, stir, what to be evaporated to relative density at 80 DEG C be 1.30Extract;
The 5th step, extract is mixed with dextrin, wet granulation, dry, make.
Reference examples 2
Reference examples 2 is with the difference of embodiment 3: menthol, after decocting, does not filter by milipore filter, concreteRefer to:
Be used for the treatment of a pharmaceutical composition for the infection of the upper respiratory tract, include following raw material: Chinese ephedra 45kg, Radix Glycyrrhizae25kg, Radix Isatidis 30kg, radix bupleuri 15kg, tuber of pinellia 7kg, root of large-flowered skullcap 7kg, dandelion 15kg, dried orange peel 7kg, balloonflower root 4kg, menthol6kg, windproof 4kg, capsule of weeping forsythia 8kg, datura flower 12kg, semen brassicae 12kg, DEXTRIN kg.
Preparation method is:
The 1st step, get Chinese ephedra, Radix Glycyrrhizae, Radix Isatidis, radix bupleuri, the root of large-flowered skullcap, dandelion, dried orange peel, balloonflower root, windproof, the capsule of weeping forsythia, datura flower,Semen brassicae, adds the ethanol water (the shared volume ratio of ethanol of ethanol water is 45%) of 11 times of above medicinal material gross weights,Decoct 3 hours, after elimination residue, decocting liquid is reclaimed to ethanol, obtain thick paste;
The 2nd step, get the tuber of pinellia, add the water of 9 times of tuber of pinellia weight, decoct 2 hours, elimination residue, obtains leaching liquor I;
The 3rd step, get menthol, add the water of 9 times of menthol weight, decoct 0.7 hour, elimination residue, obtains leaching liquorII；
The 4th step, by thick paste, leaching liquor I, leaching liquor II, stir, the relative density being evaporated at 80 DEG C is1.30 extract;
The 5th step, extract is mixed with dextrin, wet granulation, dry, make.
Content test
The HPLC detection method of the content of ephedrine hydrochloride is as follows:
According to high effective liquid chromatography for measuring, taking octadecylsilane chemically bonded silica as filler, with acetonitrile-0.1% phosphoric acidSolution (containing 0.1% triethylamine) is (3:97) mobile phase, and detection wavelength is 205nm. Number of theoretical plate is pressed ephedrine hydrochloride calculating shouldBe not less than 4000. Get ephedrine hydrochloride reference substance appropriate, accurately weighed, the hydrochloric acid solution that adds 0.1mol/L is made every 1ml containing 45 μThe solution of g, to obtain final product. Get this product under content uniformity item, porphyrize, gets 1g, accurately weighed, adds 10ml distilled water and strong ammonia solution0.5ml, with extracted by ether 5 times (30ml, 30ml, 20ml, 20ml, 20ml), merge ether solution, add ethanol solution hydrochloride (1 →20) 2ml, mixes, and low temperature reclaims solvent to dry, and residue adds ethanol 5ml to be made to dissolve, and is transferred in 25ml measuring bottle, adds 0.1mol/LHydrochloric acid solution is diluted to scale, shakes up, and to obtain final product. Accurate reference substance solution and the each 10 μ l of need testing solution, the injection liquid drawn respectivelyChromatography, measures, and the results are shown in following table.
Carry out long-term stable experiment with listing under terms of packing, 25 DEG C ± 2 DEG C of temperature, relative humidity is 60% ± 5%,0, sample respectively detection level 3,6,9,12,18,24 the end of month.
Table 1 content and stability test result
As can be seen from the table, in reference examples 1, because the tuber of pinellia is to extract with other component simultaneously, it containsDrug ingedient has had influence on the leaching of ephedrine, makes its content lower; In reference examples 2 owing to menthol not being carried out to film separationRemoval of impurities, brings to product the impurity wherein containing into, has had influence on the long-term storing stability of ephedrine.
The test of pesticide effectiveness
1. separate heat test
Body weight 160-200g and body temperature are changed to the female rats random packet that is no more than 0.3 DEG C, 10 every group, fill with respectivelyStomach gives granule medicament (200mg/kg), aspirin 0.3g/kg (positive group) and the equivalent physiological saline of embodiment 1-3 gained(control group), after every mouse administration 30min in back hypodermic injection 2,4-DNP 1ml/100g (25mg/kg), respectively atAfter injection, 60,90,120,150,180min is measured in the same method each mouse anus temperature, result of the test is as shown in table 2.
Table 2 causes the impact of rat fever on 2,4-DNP
With relatively * p < 0.05 of model group
From table data can find out, the solution thermal effect of granule provided by the invention is better than positive group, and embodiment 3Successful be better than embodiment 1 and embodiment 2.
2. analgesic test
40 of the female small white mouses of getting body weight 20 ± 2g, are divided into: blank group (physiological saline), positive drug group at random(aspirin 0.15g/kg), pharmaceutical composition high dose group of the present invention (200mg/kg), medicinal granule low dosage of the present inventionGroup (100mg/kg), by after above-mentioned dosed administration, is injected 0.6% glacial acetic acid 0.1mL/10g, record respectively at 30 minutes pneumoretroperitoneumsWrithing number of times in 10 minutes after injection algogen, statistics is as shown in table 3.
Table 3 writhing number of times statistics (X ± S)
With relatively * p < 0.05 of blank group
Result of the test shows that positive drug medicine group of the present invention and extract high dose group can significantly reduce acetic acid induced miceWrithing response number of times, low dose group can reduce the writhing response number of times of acetic acid induced mice, has good analgesia effect.
3. anti-inflammatory test
Get body weight and be the male mice random packet of 23-26 gram, 10 every group, gavage gives drug particles of the present invention respectivelyAgent 200mg/kg and 100mg/kg, prednisone 10mg/kg (positive group) and equivalent physiological saline (control group), once a day, connectContinuous three days, be only evenly coated with dimethylbenzene 0.005ml/ to for after last administration 40 minutes the left ear of animal. Causing execution in scorching latter 30 minutesThe stainless steel punching pin that animal is 8mm with diameter takes off left and right same area auricle, weighs, and is calculated as follows swelling and swellingInhibiting rate, result is as shown in table 4.
Swelling=(left auricle weight-auris dextra sheet weight)
Inhibitory rate of intumesce=(1-administration group swelling/control group swelling) × 100%
Table 4 paraxylene causes the impact of mice auricle swelling
With relatively * p < 0.05 of model group
Result demonstration, it is little that drug particles high dose group of the present invention, low dose group and prednisone group all can suppress xylene valueMouse ear swelling, relatively has significant difference with control group, shows that pharmaceutical composition of the present invention has obvious antiinflammatory action.
4. In vitro Bactericidal Experiments
The part test result of the minimum inhibitory concentration (MIC) of pharmaceutical composition of the present invention is as shown in table 5-1 and table 5-2.
The MIC (mg/ml) (twice test mean value) of table 5-1 to clinical isolates strain
The MIC of table 5-2 to reference culture
Result shows: medicinal granule of the present invention to the common pathogen of clinical separation all demonstrate have certain antibacterialEffect.
5. mouse ammoniacal liquor is drawn to the impact of coughing
Get 56 of male mouse of kunming, body weight 15-17g, is divided at random: blank group (physiological saline), positive drug groupBenproperine phosphate (0.05g/kg), drug particles high dose group of the present invention (200mg/kg), drug particles low dosage of the present inventionGroup (100mg/kg) is by after above-mentioned dosed administration, and administration volume is 20ml/kg body weight, and mouse is administration in batches, and 4 every batch, every groupEach 1 mouse. Each batch of mouse accepted ammonia spraying in bell jar after 4 hours in administration, when spraying stops, take out immediately mouse,Then observe and record the number of times of coughing in the incubation period and 5 minutes of mouse cough. The results are shown in Table 6
Table 6 draws the impact (X ± S) of coughing incubation period and cough number of times due to mouse ammoniacal liquor
With relatively * p < 0.05 of blank group
Chinese medicine preparation of the present invention is used in 2006 to 2012 the routine patients of clinical observation upper respiratory tract infection 120, facesBed is reported as follows:
1, physical data
In 120 routine patients, women's 60 examples, the male sex's 60 examples, at minimum 7 years old of age, maximum 67 years old, the course of disease was many at 1 day to 7 days,43.2 years old mean age.
2, diagnostic criteria
Reference " traditional Chinese medical science disease Standardization of diagnosis and curative effect ":
Primary symptom: (1) body heat, (2) dislike wind; Inferior disease: (1) pharyngalgia, (2) are thirsty, (3) cough, (4) sweating, (5) nasal obstruction
Runny nose. The micro-Huang of thin white fur of tongue or thin Huang, superficial and rapid pulse or sliding number. Possess 2 of primary symptoms and time disease more than 2 or 2, withTime tool
Standby above-mentioned tongue pulse condition person.
3, methods for the treatment of
Granule, every day three times, each 10g, 5 days per courses for the treatment of
4, treatment results:
4.1 references " traditional Chinese medical science disease Standardization of diagnosis and curative effect ":
Cure: cardinal symptom, sign are alleviated completely or substantially, it is normal that objective indicator is recovered;
Effective: cardinal symptom, sign are obviously alleviated, objective indicator approaches normal;
Effective: cardinal symptom, sign take a turn for the better, and objective indicator makes moderate progress;
Invalid: cardinal symptom, sign are unchanged, objective indicator changes not obvious or increases the weight of.
4.2 results: in 120 routine patients, cure 95 examples (79.2%), effective 16 examples (13.3%), effective 7 examples (5.8%),Invalid 2 examples (1.7%), total effective rate is 98.3%.
Below model case:
Case 1
Man, 8 years old, within continuous three days, sneeze, cough, taken the standing cold drug inefficacy of family, the 4th day night is unexpectedFever, takes temperature 39.5 DEG C. On inspection, this children's pars oralis pharyngis redness, antiadoncus, in adopting the measure of control body temperatureTake Chinese medicinal granule of the present invention, take two days, every day three times, each 10g, transference cure, recovers normal.
Case 2
Women, 36 years old, pharyngalgia, photophobia, sheds tears, and eye is itched, is generated heat, and 38.5 DEG C of body temperature check and find pharyngeal cavity and combinationFilm is obviously congested, and routine blood test white blood cell count(WBC) reduces, and percentage of lymphocyte increases. Take Chinese medicinal granule provided by the invention, everyThey three times, each 10g, after 1 day, temperature recovery is normal, takes 3 days, and transference cure, recovers normal.
Claims (4)
1. be used for the treatment of a pharmaceutical composition for the infection of the upper respiratory tract, described pharmaceutical composition be by by weight asLower component is made: 40～50 parts, Chinese ephedra, 20～30 parts, Radix Glycyrrhizae, 20～40 parts of Radix Isatidis, 10～20 parts of radix bupleuri, the tuber of pinellia 5～10Part, 5～10 parts of the roots of large-flowered skullcap, 10～20 parts of dandelions, 5～10 parts of dried orange peels, 3～5 parts of balloonflower roots, 4～8 parts of menthols, windproof 3～5 parts,6～12 parts of the capsules of weeping forsythia, 10～15 parts of datura flowers, 10～15 parts of semen brassicaes, 30～50 parts, dextrin; The preparation of described pharmaceutical compositionMethod is:
The 1st step, get Chinese ephedra, Radix Glycyrrhizae, Radix Isatidis, radix bupleuri, the root of large-flowered skullcap, dandelion, dried orange peel, balloonflower root, windproof, the capsule of weeping forsythia, datura flower, sinapsis albaSon, adds the ethanol water of 10～12 times of above medicinal material gross weights, decocts 2～4 hours, after elimination residue, decocting liquid is reclaimedEthanol, obtains thick paste;
The 2nd step, get the tuber of pinellia, add the water of 8～10 times of tuber of pinellia weight, decoct 1～3 hour, elimination residue, obtains leaching liquor;
The 3rd step, get menthol, add the water of 8～10 times of menthol weight, decoct 0.5～1 hour, elimination residue, by extractSend into milipore filter and filter, obtain ultrafiltrate;
The 4th step, thick paste, leaching liquor, ultrafiltrate are merged, stir, the relative density being evaporated at 80 DEG C is1.25～1.39 extract;
The 5th step, extract is mixed with dextrin, granulate, dry, make.
2. the pharmaceutical composition that is used for the treatment of the infection of the upper respiratory tract according to claim 1, is characterized in that: describedIn 1 step, the shared volume ratio of the ethanol of ethanol water is 40%～50%.
3. the pharmaceutical composition that is used for the treatment of the infection of the upper respiratory tract according to claim 1, is characterized in that: described is superThe molecular cut off of filter membrane is 200,000～400,000.
4. the pharmaceutical composition that is used for the treatment of the infection of the upper respiratory tract according to claim 1, is characterized in that: describedIn 5 steps, granulation is to pass through wet granulation.
Priority Applications (1)
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| CN105770012A (en) * | 2014-11-18 | 2016-07-20 | 郝建友 | Preparation method of injection liquid for treating upper respiratory infection |
| CN105687335A (en) * | 2014-11-18 | 2016-06-22 | 郝建友 | Injection for treating upper respiratory tract infection |
| CN105663258A (en) * | 2014-11-18 | 2016-06-15 | 郝建友 | Preparation method of injection for treating upper respiratory infection |
| CN104721508B (en) * | 2015-03-15 | 2018-09-18 | 吉林大学 | A kind of pharmaceutical composition and preparation method for treating the infection of the upper respiratory tract |
| CN105396114A (en) * | 2015-12-28 | 2016-03-16 | 刘树芹 | Medicine composition for treating respiratory tract infection |
| CN105617095A (en) * | 2016-01-27 | 2016-06-01 | 朱德密 | Oral liquid for acute upper respiratory infection in children and preparation method |
| CN106728164A (en) * | 2017-02-15 | 2017-05-31 | 成都市飞龙水处理技术研究所青白江第分所 | A kind of Chinese medicine composition for treating the infection of the upper respiratory tract and tonsillitis |
| WO2022217319A1 (en) * | 2021-04-14 | 2022-10-20 | Liquim Pty Ltd | Composition for prophylaxis against pathogens and methods of use |
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| CN102380006A (en) * | 2011-10-18 | 2012-03-21 | 孙克勤 | Traditional Chinese medicine composition for treating upper respiratory tract infection |
| CN102641335A (en) * | 2012-05-21 | 2012-08-22 | 深圳市齐旺投资有限公司 | Traditional Chinese medicine composition for treating upper respiratory tract viral infection and preparation method thereof |
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| IL168975A (en) * | 2005-06-02 | 2014-11-30 | Respinova Ltd | Pulsating inhaler for treating upper respiratory disorders |
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| CN102380006A (en) * | 2011-10-18 | 2012-03-21 | 孙克勤 | Traditional Chinese medicine composition for treating upper respiratory tract infection |
| CN102641335A (en) * | 2012-05-21 | 2012-08-22 | 深圳市齐旺投资有限公司 | Traditional Chinese medicine composition for treating upper respiratory tract viral infection and preparation method thereof |
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| 小儿急性上呼吸道病毒感染中医诊疗指南;汪受传;《南京中医药大学学报》;20110510;第27卷(第03期);第204-208页 * |
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