CN105396114A - Medicine composition for treating respiratory tract infection - Google Patents
Medicine composition for treating respiratory tract infection Download PDFInfo
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- CN105396114A CN105396114A CN201511003729.5A CN201511003729A CN105396114A CN 105396114 A CN105396114 A CN 105396114A CN 201511003729 A CN201511003729 A CN 201511003729A CN 105396114 A CN105396114 A CN 105396114A
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Abstract
The invention relates to a medicine composition for treating respiratory tract infection and application thereof. The medicine composition comprises puffballs, aristolochia debilis, dutchmanspipe vines, asparagus cochinchinensis, licorice roots, myrobalan, dandelion, scutellaria baicalensis, fructus forsythiae, isatis roots, mulberry twigs, shaddock peel, pepper, folium artemisiae argyi, agastache rugosus, eupatorium fortunei, angelica dahurica, pericarpium citri reticulatae, poria cocos, endothelium corneum gigeriae galli, hawthorn fruits, ginger, schizonepeta, divaricate saposhnikovia roots, radix angelicae pubescentis, Chinese thorowax roots, ligusticum wallichii, fructus aurantii, platycodon grandiflorum, betel nuts and trichosanthes kirilowii maxim. The medicine composition is a traditional Chinese medicine preparation, traditional Chinese medicine which is placid in smell is selected, and unpleasant smell of all types of traditional Chinese medicine is mutually buried, so that the medicine composition tastes good by a patient, and compliance of the patient is improved.
Description
Technical field
The invention belongs to treatment by Chinese herbs field, particularly relate to a kind of medical composition and its use for the treatment of respiratory tract infection.
Background technology
Along with the development of society, the appearance repeatedly of dust, haze weather especially in recent years, causes respiratory tract disease sickness rate to have rising, and our said respiratory tract infection is divided into upper respiratory tract infection and lower respiratory infection usually.Respiratory tract infection is modal infectious disease.Upper respiratory tract infection refers to the acutely inflamed general name between nasal cavity to throat.Lower respiratory infection comprises acute bronchitis, chronic bronchitis, pneumonia, bronchiectasis etc.
According to the viewpoint of theory of Chinese medical science, it is generally acknowledged that respiratory tract infection reason is caused by exopathogenic factor and endogenous cause of ill.Exopathogenic factor comprises:
(1) environmental pollution such as dust, haze etc. easily causes external environment atmospheric moisture weight, special spring, summer, autumn, and dampness is heavy easily causes heat not easily to leave, and causes air wet, sultry, makes people be subject to the invasion of hygropyrexia pathogenic factor, easily suffers from " damp-warm diseases ".The hygropyrexia pathogenic factor of traditional Chinese medical science indication comprises the pathogenic bacterium of the clinical indication respiratory tract infection of doctor trained in Western medicine, as: antibacterial, virus etc.
(2) the acute large change of circumstance of temperature difference is in, as suffered from cold, improper using air-condition causes uneven in temperature, the factor such as sometimes cold and sometimes hot or eat cold, greasy food, normal food foods etc. are easily raw wet, and often eat fiber crops, peppery diet, blocked shot, wine is easily heat-transformation in vivo, so modern's body constitution is because environment and dietary structure change, easily form damp-heat constitution.
Doctor trained in Western medicine mainly adopts symptomatic treatment, through Antibiotic therapy alone, easily produces drug resistance to antibiotic, invisiblely too increases patient medical expense, uses antibiotic usage can increase irritated rate simultaneously, and as everyone knows, the irritated rate of crowd of damp-heat constitution can be higher.Irritated harm slightly easily causes various hypersensitive dermatosis; seriously causing death can be led; in use antibiotic usage kill bacteria simultaneously; human normal cell is also produced a very large impact; often or life-time service antibiotic; easily cause human leukocytes quantity to reduce, immunity degradation, life-time service antibiotic easily causes human flora to lack of proper care easily forming fungal infection.Not only to treat respiratory tract infection curative effect bad because of numeration of leukocyte low use antibiotic for the patient of 7, special population hypoimmunity, and frequent use also can make a big impact to the state of an illness of cancer own.
Treatment at present for respiratory tract disease there is no specific drug so far, Western medicine and expensive, and curative effect can not be entirely satisfactory in addition, and it is large to have side effect, effective slow, the shortcoming such as transference cure is slow, therapeutic effect is not good enough in the process of in use medicine.
Summary of the invention:
For the defect of prior art, the present invention be directed to the present situation for the treatment of respiratory tract infection at present, the pharmaceutical composition that a kind of therapeutic effect is good is provided, and has no side effect.
Specifically, the present invention realizes like this.
Inventor provides a kind of prescriptions of Chinese medicine for the treatment of respiratory tract infection according to drug matching experience, comprises following Chinese medicine: Lasiosphaera Seu Calvatia, Fructus Aristolochiae, Herba Aristolochiae, Radix Asparagi, Radix Glycyrrhizae, Fructus Chebulae, Herba Taraxaci, Radix Scutellariae, Fructus Forsythiae, Radix Isatidis, Ramulus Mori, Pericarpium Citri grandis, Pericarpium Zanthoxyli, Folium Artemisiae Argyi, Herba Pogostemonis, Herba Eupatorii, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Poria, Endothelium Corneum Gigeriae Galli, Fructus Crataegi, Rhizoma Zingiberis Recens, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Pubescentis, Radix Bupleuri, Rhizoma Chuanxiong, Fructus Aurantii, Radix Platycodonis, Semen Arecae, Fructus Trichosanthis.
Each raw material dosage of prescription all has good curative effect in weight portion scope of the present invention, described formula and weight portion are: Radix Bupleuri 10-30 part, Herba Schizonepetae 10-25 part, Fructus Crataegi 10-20 part, Radix Scutellariae 20-30 part, Lasiosphaera Seu Calvatia 1-5 part, Fructus Aristolochiae 3-15 part, Herba Aristolochiae 3-10 part, Radix Asparagi 3-15 part, Radix Glycyrrhizae 3-8 part, Fructus Chebulae 1-5 part, Herba Taraxaci 10-20 part, Fructus Forsythiae 8-15 part, Radix Isatidis 10-25 part, Ramulus Mori 15-25 part, Pericarpium Citri grandis 8-17 part, Pericarpium Zanthoxyli 3-10 part, Folium Artemisiae Argyi 1-7 part, Herba Pogostemonis 3-11 part, Herba Eupatorii 5-15 part, Radix Angelicae Dahuricae 5-17 part, Pericarpium Citri Reticulatae 4-18 part, Poria 5-14 part, Endothelium Corneum Gigeriae Galli 3-10 part, Rhizoma Zingiberis Recens 1-7 part, Radix Saposhnikoviae 5-11 part, Radix Angelicae Pubescentis 3-11 part, Rhizoma Chuanxiong 4-11 part, Fructus Aurantii 6-11 part, Radix Platycodonis 5-13 part, Semen Arecae 3-17 part, Fructus Trichosanthis 3-12 part.
For reaching optimum effect, to described formula and weight portion be: Radix Bupleuri 20 parts, Herba Schizonepetae 18 parts, Fructus Crataegi 15 parts, Radix Scutellariae 25 parts, Lasiosphaera Seu Calvatia 3 parts, Fructus Aristolochiae 7.5 parts, Herba Aristolochiae 6.5 parts, Radix Asparagi 5 parts, 5 parts, Radix Glycyrrhizae, Fructus Chebulae 4 parts, Herba Taraxaci 15 parts, Fructus Forsythiae 11 parts, Radix Isatidis 20 parts, Ramulus Mori 20 parts, Pericarpium Citri grandis 12 parts, 6 parts, Pericarpium Zanthoxyli, Folium Artemisiae Argyi 3 parts, Herba Pogostemonis 7 parts, Herba Eupatorii 10 parts, the Radix Angelicae Dahuricae 10 parts, Pericarpium Citri Reticulatae 12 parts, 8 parts, Poria, Endothelium Corneum Gigeriae Galli 7.5 parts, 3 parts, Rhizoma Zingiberis Recens, Radix Saposhnikoviae 8 parts, Radix Angelicae Pubescentis 6 parts, Rhizoma Chuanxiong 7.5 parts, Fructus Aurantii 9 parts, Radix Platycodonis 9 parts, Semen Arecae 6 parts, Fructus Trichosanthis 6 parts.
Or:
Radix Bupleuri 17 parts, Herba Schizonepetae 15 parts, Fructus Crataegi 18 parts, Radix Scutellariae 20 parts, Lasiosphaera Seu Calvatia 3.5 parts, Fructus Aristolochiae 5.5 parts, Herba Aristolochiae 4.5 parts, Radix Asparagi 6 parts, 4 parts, Radix Glycyrrhizae, Fructus Chebulae 3.5 parts, Herba Taraxaci 17 parts, Fructus Forsythiae 10 parts, Radix Isatidis 17 parts, Ramulus Mori 18 parts, Pericarpium Citri grandis 10 parts, 4 parts, Pericarpium Zanthoxyli, Folium Artemisiae Argyi 3.5 parts, Herba Pogostemonis 5 parts, Herba Eupatorii 8 parts, the Radix Angelicae Dahuricae 8 parts, Pericarpium Citri Reticulatae 10 parts, 7 parts, Poria, Endothelium Corneum Gigeriae Galli 6.5 parts, 3 parts, Rhizoma Zingiberis Recens, Radix Saposhnikoviae 7.5 parts, Radix Angelicae Pubescentis 4 parts, Rhizoma Chuanxiong 5 parts, Fructus Aurantii 7 parts, Radix Platycodonis 6 parts, Semen Arecae 4 parts, Fructus Trichosanthis 5 parts.
Pharmaceutical composition of the present invention, the purposes of described pharmaceutical composition mainly in preparation treatment respiratory tract infection medicine, is especially applicable to the purposes in treatment upper respiratory tract infection medicine.
The present invention is to above prescription through conscientious research, and according to the reasonability of middle medical drugs, invention proposes concrete a kind of preparation method for the treatment of the pharmaceutical composition of respiratory tract infection, and concrete steps are:
(1) Fructus Forsythiae, Ramulus Mori, Pericarpium Citri grandis, Pericarpium Zanthoxyli, Rhizoma Zingiberis Recens, Herba Schizonepetae, Lasiosphaera Seu Calvatia, Fructus Aristolochiae, Fructus Trichosanthis, Herba Aristolochiae, Radix Asparagi, Radix Glycyrrhizae, Fructus Chebulae, Herba Taraxaci, Folium Artemisiae Argyi and Rhizoma Chuanxiong mixing is taken, add 12 times of water soakings, then decoct 2 times, 2 hours first times, second time 1 hour, merges decoction liquor, filters, being evaporated to relative density is 1.13, for subsequent use;
(2) take Radix Bupleuri, Fructus Aurantii, Radix Platycodonis, Semen Arecae, Fructus Crataegi, Radix Scutellariae and Herba Pogostemonis mixing, be ground into coarse powder, and 10 times of volumetric concentrations are the alcoholic solution reflux, extract, 3 times of 85%, each 2 hours, merge ethanol extract, for subsequent use;
(3) Herba Eupatorii, the Radix Angelicae Dahuricae, Endothelium Corneum Gigeriae Galli, Radix Saposhnikoviae, Radix Angelicae Pubescentis, Radix Isatidis, Poria and tangerine peel powder are broken into coarse powder, 11 times of volumetric concentrations are the alcoholic solution reflux, extract, 2 times of 70%, each 1.5 hours, merge ethanol extract, for subsequent use;
(4) ethanol extract of step (2) and (3) is mixed the concentrated solution adding step (1) more wherein, stir, hold over night, centrifugal, supernatant is condensed into extractum, lyophilization after reclaiming ethanol, pulverize, obtain clear paste powder;
(5) mixed with the mixture of appropriate lactose and dextrin by step (4) gained clear paste powder, stir and be heated to 80-90 DEG C, cross 100 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
In above-mentioned preparation method, clear paste powder is 1:0.1-0.2 with the weight consumption ratio of lactose and dextrin.
In above-mentioned preparation method, the weight ratio of lactose and dextrin is 1-2:1.
Compared with prior art, the granule that the present invention treats respiratory tract infection has the following advantages:
(1) the present invention is Chinese medicine preparation, but the Chinese medicine that selected abnormal smells from the patient is gentle, the unpleasant taste between each Chinese medicine is buried mutually, makes patient's mouthfeel better, improves the compliance of patient.
(2) the present invention adopts the Chinese crude drug of different properties, carry out scientific compatibility, monarch is complete, desirable therapeutic effect can be reached, improve the probability of prevention and therapy respiratory tract disease, all have good therapeutic effect through pharmacology test and clinical trial, toxic and side effects is little, for the progress of clinical application and society provides probability.
(3) the present invention is according to theory of Chinese medical science, and Chinese medicine of the present invention, on the basis for the treatment of respiratory tract infection, also takes into account promoting the circulation of QI to relieve pain, the functions such as antiinflammatory dissipating blood stasis, thus improves the passive protective physical fitness that the function improving respiratory tract further improves patient.
Specific embodiment
The above; be only the specific embodiment of the present invention, protection scope of the present invention is not limited thereto, and is anyly familiar with those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.
Embodiment 1: a kind of pharmaceutical composition being used for the treatment of respiratory tract infection, comprises following weight portion Chinese medicine:
Radix Bupleuri 10 parts, Herba Schizonepetae 10-part, Fructus Crataegi 10 parts, Radix Scutellariae 20 parts, Lasiosphaera Seu Calvatia 1 part, Fructus Aristolochiae 3 parts, Herba Aristolochiae 3 parts, Radix Asparagi 3 parts, 3 parts, Radix Glycyrrhizae, Fructus Chebulae 1 part, Herba Taraxaci 10 parts, Fructus Forsythiae 8 parts, Radix Isatidis 10 parts, Ramulus Mori 15 parts, Pericarpium Citri grandis 8 parts, 3 parts, Pericarpium Zanthoxyli, Folium Artemisiae Argyi 1 part, Herba Pogostemonis 3 parts, Herba Eupatorii 5 parts, Radix Angelicae Dahuricae 5-part, Pericarpium Citri Reticulatae 4 parts, 5 parts, Poria, Endothelium Corneum Gigeriae Galli 3 parts, 1 part, Rhizoma Zingiberis Recens, Radix Saposhnikoviae 5 parts, Radix Angelicae Pubescentis 3 parts, Rhizoma Chuanxiong 4 parts, Fructus Aurantii 6 parts, Radix Platycodonis 5 parts, Semen Arecae 3 parts, Fructus Trichosanthis 3 parts.
Concrete preparation method is:
(1) Fructus Forsythiae, Ramulus Mori, Pericarpium Citri grandis, Pericarpium Zanthoxyli, Rhizoma Zingiberis Recens, Herba Schizonepetae, Lasiosphaera Seu Calvatia, Fructus Aristolochiae, Fructus Trichosanthis, Herba Aristolochiae, Radix Asparagi, Radix Glycyrrhizae, Fructus Chebulae, Herba Taraxaci, Folium Artemisiae Argyi and Rhizoma Chuanxiong mixing is taken, add 12 times of water soakings, then decoct 2 times, 2 hours first times, second time 1 hour, merges decoction liquor, filters, being evaporated to relative density is 1.13, for subsequent use;
(2) take Radix Bupleuri, Fructus Aurantii, Radix Platycodonis, Semen Arecae, Fructus Crataegi, Radix Scutellariae and Herba Pogostemonis mixing, be ground into coarse powder, and 10 times of volumetric concentrations are the alcoholic solution reflux, extract, 3 times of 85%, each 2 hours, merge ethanol extract, for subsequent use;
(3) Herba Eupatorii, the Radix Angelicae Dahuricae, Endothelium Corneum Gigeriae Galli, Radix Saposhnikoviae, Radix Angelicae Pubescentis, Radix Isatidis, Poria and tangerine peel powder are broken into coarse powder, 11 times of volumetric concentrations are the alcoholic solution reflux, extract, 2 times of 70%, each 1.5 hours, merge ethanol extract, for subsequent use;
(4) ethanol extract of step (2) and (3) is mixed the concentrated solution adding step (1) more wherein, stir, hold over night, centrifugal, supernatant is condensed into extractum, lyophilization after reclaiming ethanol, pulverize, obtain clear paste powder;
(5) step (4) gained clear paste powder is mixed with the lactose of 10% and the mixture of dextrin (ratio of lactose and dextrin is 1:1), stir and be heated to 80-90 DEG C, cross 100 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 2: a kind of pharmaceutical composition being used for the treatment of respiratory tract infection, comprises following weight portion Chinese medicine:
Radix Bupleuri 30 parts, Herba Schizonepetae 25 parts, Fructus Crataegi 20 parts, Radix Scutellariae 30 parts, Lasiosphaera Seu Calvatia 5 parts, Fructus Aristolochiae 15 parts, Herba Aristolochiae 10 parts, Radix Asparagi 15 parts, 8 parts, Radix Glycyrrhizae, Fructus Chebulae 5 parts, Herba Taraxaci 20 parts, Fructus Forsythiae 15 parts, Radix Isatidis 25 parts, Ramulus Mori 25 parts, Pericarpium Citri grandis 17 parts, 10 parts, Pericarpium Zanthoxyli, Folium Artemisiae Argyi 7 parts, Herba Pogostemonis 11 parts, Herba Eupatorii 15 parts, the Radix Angelicae Dahuricae 17 parts, Pericarpium Citri Reticulatae 18 parts, 14 parts, Poria, Endothelium Corneum Gigeriae Galli 10 parts, 7 parts, Rhizoma Zingiberis Recens, Radix Saposhnikoviae 11 parts, Radix Angelicae Pubescentis 11 parts, Rhizoma Chuanxiong 11 parts, Fructus Aurantii 11 parts, Radix Platycodonis 13 parts, Semen Arecae 17 parts, Fructus Trichosanthis 12 parts.
Concrete preparation method is:
(1) Fructus Forsythiae, Ramulus Mori, Pericarpium Citri grandis, Pericarpium Zanthoxyli, Rhizoma Zingiberis Recens, Herba Schizonepetae, Lasiosphaera Seu Calvatia, Fructus Aristolochiae, Fructus Trichosanthis, Herba Aristolochiae, Radix Asparagi, Radix Glycyrrhizae, Fructus Chebulae, Herba Taraxaci, Folium Artemisiae Argyi and Rhizoma Chuanxiong mixing is taken, add 12 times of water soakings, then decoct 2 times, 2 hours first times, second time 1 hour, merges decoction liquor, filters, being evaporated to relative density is 1.13, for subsequent use;
(2) take Radix Bupleuri, Fructus Aurantii, Radix Platycodonis, Semen Arecae, Fructus Crataegi, Radix Scutellariae and Herba Pogostemonis mixing, be ground into coarse powder, and 10 times of volumetric concentrations are the alcoholic solution reflux, extract, 3 times of 85%, each 2 hours, merge ethanol extract, for subsequent use;
(3) Herba Eupatorii, the Radix Angelicae Dahuricae, Endothelium Corneum Gigeriae Galli, Radix Saposhnikoviae, Radix Angelicae Pubescentis, Radix Isatidis, Poria and tangerine peel powder are broken into coarse powder, 11 times of volumetric concentrations are the alcoholic solution reflux, extract, 2 times of 70%, each 1.5 hours, merge ethanol extract, for subsequent use;
(4) ethanol extract of step (2) and (3) is mixed the concentrated solution adding step (1) more wherein, stir, hold over night, centrifugal, supernatant is condensed into extractum, lyophilization after reclaiming ethanol, pulverize, obtain clear paste powder;
(5) step (4) gained clear paste powder is mixed with the lactose of 20% and the mixture of dextrin (ratio of lactose and dextrin is 2:1), stir and be heated to 80-90 DEG C, cross 100 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 3: a kind of pharmaceutical composition being used for the treatment of respiratory tract infection, comprises following weight portion Chinese medicine:
Radix Bupleuri 20 parts, Herba Schizonepetae 18 parts, Fructus Crataegi 15 parts, Radix Scutellariae 25 parts, Lasiosphaera Seu Calvatia 3 parts, Fructus Aristolochiae 7.5 parts, Herba Aristolochiae 6.5 parts, Radix Asparagi 5 parts, 5 parts, Radix Glycyrrhizae, Fructus Chebulae 4 parts, Herba Taraxaci 15 parts, , Fructus Forsythiae 11 parts, Radix Isatidis 20 parts, Ramulus Mori 20 parts, Pericarpium Citri grandis 12 parts, 6 parts, Pericarpium Zanthoxyli, Folium Artemisiae Argyi 3 parts, Herba Pogostemonis 7 parts, Herba Eupatorii 10 parts, the Radix Angelicae Dahuricae 10 parts, Pericarpium Citri Reticulatae 12 parts, 8 parts, Poria, Endothelium Corneum Gigeriae Galli 7.5 parts, 3 parts, Rhizoma Zingiberis Recens, Radix Saposhnikoviae 8 parts, Radix Angelicae Pubescentis 6 parts, Rhizoma Chuanxiong 7.5 parts, Fructus Aurantii 9 parts, Radix Platycodonis 9 parts, Semen Arecae 6 parts, Fructus Trichosanthis 6 parts.
Concrete preparation method is:
(1) Fructus Forsythiae, Ramulus Mori, Pericarpium Citri grandis, Pericarpium Zanthoxyli, Rhizoma Zingiberis Recens, Herba Schizonepetae, Lasiosphaera Seu Calvatia, Fructus Aristolochiae, Fructus Trichosanthis, Herba Aristolochiae, Radix Asparagi, Radix Glycyrrhizae, Fructus Chebulae, Herba Taraxaci, Folium Artemisiae Argyi and Rhizoma Chuanxiong mixing is taken, add 12 times of water soakings, then decoct 2 times, 2 hours first times, second time 1 hour, merges decoction liquor, filters, being evaporated to relative density is 1.13, for subsequent use;
(2) take Radix Bupleuri, Fructus Aurantii, Radix Platycodonis, Semen Arecae, Fructus Crataegi, Radix Scutellariae and Herba Pogostemonis mixing, be ground into coarse powder, and 10 times of volumetric concentrations are the alcoholic solution reflux, extract, 3 times of 85%, each 2 hours, merge ethanol extract, for subsequent use;
(3) Herba Eupatorii, the Radix Angelicae Dahuricae, Endothelium Corneum Gigeriae Galli, Radix Saposhnikoviae, Radix Angelicae Pubescentis, Radix Isatidis, Poria and tangerine peel powder are broken into coarse powder, 11 times of volumetric concentrations are the alcoholic solution reflux, extract, 2 times of 70%, each 1.5 hours, merge ethanol extract, for subsequent use;
(4) ethanol extract of step (2) and (3) is mixed the concentrated solution adding step (1) more wherein, stir, hold over night, centrifugal, supernatant is condensed into extractum, lyophilization after reclaiming ethanol, pulverize, obtain clear paste powder;
(5) step (4) gained clear paste powder is mixed with the lactose of 15% and the mixture of dextrin (ratio of lactose and dextrin is 1.5:1), stir and be heated to 80-90 DEG C, cross 100 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 4: a kind of pharmaceutical composition being used for the treatment of respiratory tract infection, comprises following weight portion Chinese medicine:
Radix Bupleuri 17 parts, Herba Schizonepetae 15 parts, Fructus Crataegi 18 parts, Radix Scutellariae 20 parts, Lasiosphaera Seu Calvatia 3.5 parts, Fructus Aristolochiae 5.5 parts, Herba Aristolochiae 4.5 parts, Radix Asparagi 6 parts, 4 parts, Radix Glycyrrhizae, Fructus Chebulae 3.5 parts, Herba Taraxaci 17 parts, , Fructus Forsythiae 10 parts, Radix Isatidis 17 parts, Ramulus Mori 18 parts, Pericarpium Citri grandis 10 parts, 4 parts, Pericarpium Zanthoxyli, Folium Artemisiae Argyi 3.5 parts, Herba Pogostemonis 5 parts, Herba Eupatorii 8 parts, the Radix Angelicae Dahuricae 8 parts, Pericarpium Citri Reticulatae 10 parts, 7 parts, Poria, Endothelium Corneum Gigeriae Galli 6.5 parts, 3 parts, Rhizoma Zingiberis Recens, Radix Saposhnikoviae 7.5 parts, Radix Angelicae Pubescentis 4 parts, Rhizoma Chuanxiong 5 parts, Fructus Aurantii 7 parts, Radix Platycodonis 6 parts, Semen Arecae 4 parts, Fructus Trichosanthis 5 parts.
Preparation method is with embodiment 3.
Embodiment 5: antiinflammatory pharmacodynamics test.
The anti-granule of chaste tree is dispelled, and separates diaphoresis.Sending out wet wind falls apart for cold, headache general pain, and aversion to cold is lossless, nasal obstruction watery nasal discharge, and cough is commonly used to treat respiratory tract infection clinically, is used for doing positive control test in the present invention.
5.1, animal model and administration
65 mices are divided into 5 groups, and the high, medium and low dosage group of model group, positive controls, pharmaceutical composition often organizes 13, administering mode, kind and dose as table 1, Normal group 13.After successive administration 4 days, after last administration, the left ear of 30min every mice is coated with dimethylbenzene 50ul, auris dextra makes blank, cause sacrifice after scorching 15min, cut two ears, lay auricle at the two same positions of ear respectively with card punch (diameter 7mm), weigh, calculate swelling and inhibitory rate of intumesce.
Swelling=left auricle weight-auris dextra sheet weight
Table 1 tests the administering mode of each group of mice, kind and dose situation
| Group | Administering mode, kind and dose |
| Model group | Gavage, 9% normal saline 5ml |
| Pharmaceutical composition high dose group | The pharmaceutical composition 8g/kg of gavage, embodiment 3 |
| Dosage group in pharmaceutical composition | The pharmaceutical composition 4g/kg of gavage, embodiment 3 |
| Pharmaceutical composition low dose group | The pharmaceutical composition 2g/kg of gavage, embodiment 3 |
| Positive controls | Gavage, the anti-granule 8g/kg of chaste tree |
Experimental result shows, the left ear of model group mice is red and swollen, ear swelling degree is up to 0.0155 ± 0.0028g, and the ear swelling degree of pharmaceutical composition group, positive controls is all less than model group, and compare from model group and have different significant differences (P < 0.05, P < 0.01).
Table 2 respectively group medicine xylol causes the impact of mice ear
Compared with model group,
#p < 0.05,
##p < 0.01;
Compared with positive controls,
▲p < 0.05.
Shown the impact of the anti-inflammatory test ear swelling of mice by table 2 result, model modeling success can be known by model group.And positive controls and each dosage group of pharmaceutical composition all clearly can play the effect for the treatment of, main manifestations is that ear swelling reduces, and inhibitory rate of intumesce raises.Wherein pharmaceutical composition high dose group have compared with positive controls significant difference (
#p < 0.05), this shows that medicine composite for curing effect is better than positive controls.
Embodiment 6: clinical trial
6.1. physical data
The 2013-2015.03 month, receive in 194 routine patients, qualified 174 examples, wherein women 87 example, male 87 example, at minimum 10 years old of age, maximum 68 years old, 35.2 years old mean age, the course of disease was many at 1 day to 4 days, 30.6 years old mean age.
6.2. grouping and Therapeutic Method
Treatment group: often organize 87 examples, man 43 example, female 44 example, every day 3 times, each 10gl 3 days is a course for the treatment of, treats 3 courses for the treatment of altogether;
Matched group: often organize 87 examples, man 44 example, female 43 example, every day 3 times, each 15gl 3 days is a course for the treatment of, treats 3 courses for the treatment of altogether.
6.3. with reference to " Chinese medical disease Standardization of diagnosis and curative effect ": primary symptom: (1) fever of the body, (2) aversion to wind; Secondary disease: (1) pharyngalgia, (2) are thirsty, and (3) cough, (4) sweating, (5) nasal obstruction watery nasal discharge.The micro-Huang of thin white fur of tongue or BOHUANG, floating and rapid pulse or sliding number.Possess primary symptom 2 and time disease more than 2 or 2, possess above-mentioned tongue pulse condition person simultaneously.
6.4. the standard of curative effect evaluation
Cure: cardinal symptom, sign are alleviated completely or substantially, objective indicator recovers normal;
Effective: cardinal symptom, sign are obviously alleviated, objective indicator is close to normal;
Effective: cardinal symptom, sign take a turn for the better, and objective indicator makes moderate progress;
Effective percentage: (cure+effective+effectively)/diseased individuals;
Invalid: cardinal symptom, sign are unchanged, objective indicator change is not obvious or increase the weight of.
6.5. therapeutic outcome, table 3
| Cure | Effective | Effectively | Invalid | Effective percentage (%) | |
| Treatment group | 58 | 20 | 9 | 0 | 100.0 |
| Matched group | 28 | 41 | 12 | 6 | 93.1 |
In the routine patient for the treatment of group 87, cure 58 examples, effective 20 examples, effective 9 examples, invalid 0 example, total effective rate is 100%; In the routine patient of matched group 87, cure 28 examples, effective 41 examples, effective 12 examples, invalid 6 examples, total effective rate is 93.1%.
6.6. model case
Case 1: Lee, man, 29 years old, because hyperpyrexia Bu Tuilaiwo institute checks, through looking into body heat, temperature 38.7 DEG C, constantly cough, and have expectorant, gurgling with sputum, diet was not good enough, ill health.Take granules medicine medicine in the embodiment of the present invention 2 to treat, after taking 3 days, body temp recovers normal, continues to take 3 days, and the mental status takes a turn for the better, and appetite increases, recovery from illness.
Case 2: China certain, female, 35 years old, patient for three days on end watery nasal discharge, acutely cough, body temperature is unstable, but carrys out temperature 38.2 DEG C when my institute checks, both sides tonsil is slightly congested, and has serious swelling, red tongue, yellow and thin fur, treats, after taking 3 days with granules medicine medicine in the embodiment of the present invention 4, body temp recovers normal, and cough takes a turn for the better, and continues to take 3 days, the mental status takes a turn for the better, and appetite increases, recovery from illness.
Case 3: high certain, man, 45 years old, patient catches a cold 3 days, shallow complexion, emaciated physique, fatigue and weakness, and pale tongue with thin fur is white, continuous cough, and have expectorant, gurgling with sputum, treat with granules medicine medicine in the embodiment of the present invention 4, body temp recovers normal, and cough takes a turn for the better, continue to take 3 days, the mental status takes a turn for the better, and appetite increases, recovery from illness, life happiness.
Claims (10)
1. treat the pharmaceutical composition of respiratory tract infection for one kind, it is characterized in that, comprise following composition: Lasiosphaera Seu Calvatia, Fructus Aristolochiae, Herba Aristolochiae, Radix Asparagi, Radix Glycyrrhizae, Fructus Chebulae, Herba Taraxaci, Radix Scutellariae, Fructus Forsythiae, Radix Isatidis, Ramulus Mori, Pericarpium Citri grandis, Pericarpium Zanthoxyli, Folium Artemisiae Argyi, Herba Pogostemonis, Herba Eupatorii, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Poria, Endothelium Corneum Gigeriae Galli, Fructus Crataegi, Rhizoma Zingiberis Recens, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Pubescentis, Radix Bupleuri, Rhizoma Chuanxiong, Fructus Aurantii, Radix Platycodonis, Semen Arecae, Fructus Trichosanthis.
2. pharmaceutical composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Radix Bupleuri 10-30 part, Herba Schizonepetae 10-25 part, Fructus Crataegi 10-20 part, Radix Scutellariae 20-30 part, Lasiosphaera Seu Calvatia 1-5 part, Fructus Aristolochiae 3-15 part, Herba Aristolochiae 3-10 part, Radix Asparagi 3-15 part, Radix Glycyrrhizae 3-8 part, Fructus Chebulae 1-5 part, Herba Taraxaci 10-20 part, Fructus Forsythiae 8-15 part, Radix Isatidis 10-25 part, Ramulus Mori 15-25 part, Pericarpium Citri grandis 8-17 part, Pericarpium Zanthoxyli 3-10 part, Folium Artemisiae Argyi 1-7 part, Herba Pogostemonis 3-11 part, Herba Eupatorii 5-15 part, Radix Angelicae Dahuricae 5-17 part, Pericarpium Citri Reticulatae 4-18 part, Poria 5-14 part, Endothelium Corneum Gigeriae Galli 3-10 part, Rhizoma Zingiberis Recens 1-7 part, Radix Saposhnikoviae 5-11 part, Radix Angelicae Pubescentis 3-11 part, Rhizoma Chuanxiong 4-11 part, Fructus Aurantii 6-11 part, Radix Platycodonis 5-13 part, Semen Arecae 3-17 part, Fructus Trichosanthis 3-12 part.
3. pharmaceutical composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Radix Bupleuri 20 parts, Herba Schizonepetae 18 parts, Fructus Crataegi 15 parts, Radix Scutellariae 25 parts, Lasiosphaera Seu Calvatia 3 parts, Fructus Aristolochiae 7.5 parts, Herba Aristolochiae 6.5 parts, Radix Asparagi 5 parts, 5 parts, Radix Glycyrrhizae, Fructus Chebulae 4 parts, Herba Taraxaci 15 parts, Fructus Forsythiae 11 parts, Radix Isatidis 20 parts, Ramulus Mori 20 parts, Pericarpium Citri grandis 12 parts, 6 parts, Pericarpium Zanthoxyli, Folium Artemisiae Argyi 3 parts, Herba Pogostemonis 7 parts, Herba Eupatorii 10 parts, the Radix Angelicae Dahuricae 10 parts, Pericarpium Citri Reticulatae 12 parts, 8 parts, Poria, Endothelium Corneum Gigeriae Galli 7.5 parts, 3 parts, Rhizoma Zingiberis Recens, Radix Saposhnikoviae 8 parts, Radix Angelicae Pubescentis 6 parts, Rhizoma Chuanxiong 7.5 parts, Fructus Aurantii 9 parts, Radix Platycodonis 9 parts, Semen Arecae 6 parts, Fructus Trichosanthis 6 parts.
4. pharmaceutical composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Radix Bupleuri 17 parts, Herba Schizonepetae 15 parts, Fructus Crataegi 18 parts, Radix Scutellariae 20 parts, Lasiosphaera Seu Calvatia 3.5 parts, Fructus Aristolochiae 5.5 parts, Herba Aristolochiae 4.5 parts, Radix Asparagi 6 parts, 4 parts, Radix Glycyrrhizae, Fructus Chebulae 3.5 parts, Herba Taraxaci 17 parts, Fructus Forsythiae 10 parts, Radix Isatidis 17 parts, Ramulus Mori 18 parts, Pericarpium Citri grandis 10 parts, 4 parts, Pericarpium Zanthoxyli, Folium Artemisiae Argyi 3.5 parts, Herba Pogostemonis 5 parts, Herba Eupatorii 8 parts, the Radix Angelicae Dahuricae 8 parts, Pericarpium Citri Reticulatae 10 parts, 7 parts, Poria, Endothelium Corneum Gigeriae Galli 6.5 parts, 3 parts, Rhizoma Zingiberis Recens, Radix Saposhnikoviae 7.5 parts, Radix Angelicae Pubescentis 4 parts, Rhizoma Chuanxiong 5 parts, Fructus Aurantii 7 parts, Radix Platycodonis 6 parts, Semen Arecae 4 parts, Fructus Trichosanthis 5 parts.
5. prepare a preparation method for pharmaceutical composition according to claim 1, it is characterized in that, concrete step is:
(1) Fructus Forsythiae, Ramulus Mori, Pericarpium Citri grandis, Pericarpium Zanthoxyli, Rhizoma Zingiberis Recens, Herba Schizonepetae, Lasiosphaera Seu Calvatia, Fructus Aristolochiae, Fructus Trichosanthis, Herba Aristolochiae, Radix Asparagi, Radix Glycyrrhizae, Fructus Chebulae, Herba Taraxaci, Folium Artemisiae Argyi and Rhizoma Chuanxiong mixing is taken, add 12 times of water soakings, then decoct 2 times, 2 hours first times, second time 1 hour, merges decoction liquor, filters, being evaporated to relative density is 1.13, for subsequent use;
(2) take Radix Bupleuri, Fructus Aurantii, Radix Platycodonis, Semen Arecae, Fructus Crataegi, Radix Scutellariae and Herba Pogostemonis mixing, be ground into coarse powder, and 10 times of volumetric concentrations are the alcoholic solution reflux, extract, 3 times of 85%, each 2 hours, merge ethanol extract, for subsequent use;
(3) Herba Eupatorii, the Radix Angelicae Dahuricae, Endothelium Corneum Gigeriae Galli, Radix Saposhnikoviae, Radix Angelicae Pubescentis, Radix Isatidis, Poria and tangerine peel powder are broken into coarse powder, 11 times of volumetric concentrations are the alcoholic solution reflux, extract, 2 times of 70%, each 1.5 hours, merge ethanol extract, for subsequent use;
(4) ethanol extract of step (2) and (3) is mixed the concentrated solution adding step (1) more wherein, stir, hold over night, centrifugal, supernatant is condensed into extractum, lyophilization after reclaiming ethanol, pulverize, obtain clear paste powder;
(5) mixed with the mixture of appropriate lactose and dextrin by step (4) gained clear paste powder, stir and be heated to 80-90 DEG C, cross 100 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
6. the preparation method of pharmaceutical composition according to claim 5, is characterized in that, the clear paste powder described in step (5) is 1:0.1-0.2 with the weight consumption ratio of mixture.
7. the preparation method of pharmaceutical composition according to claim 5, is characterized in that, the weight consumption of the lactose described in step (5) and dextrin is than being 1-2:1.
8. the preparation method of pharmaceutical composition according to claim 6, is characterized in that, described clear paste powder is 1:0.15 with the weight consumption ratio of mixture.
9. the preparation method of pharmaceutical composition according to claim 7, is characterized in that, the weight consumption of described lactose and dextrin is than being 1.5:1.
10. pharmaceutical composition according to claim 1, is characterized in that: the application of described pharmaceutical composition in preparation treatment respiratory tract infection medicine.
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| CN105457002A (en) * | 2015-12-31 | 2016-04-06 | 段希福 | Medicine composition for treating respiratory tract infection and application thereof |
| CN111529586A (en) * | 2020-05-18 | 2020-08-14 | 广州市香雪制药股份有限公司 | A concentrated granule for preventing infection of novel coronavirus and its preparation method |
| WO2023274150A1 (en) * | 2021-06-29 | 2023-01-05 | 山东新时代药业有限公司 | Use of traditional chinese medicine composition in preparation of drug for treating cough variant asthma |
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| CN105457002A (en) * | 2015-12-31 | 2016-04-06 | 段希福 | Medicine composition for treating respiratory tract infection and application thereof |
| CN111529586A (en) * | 2020-05-18 | 2020-08-14 | 广州市香雪制药股份有限公司 | A concentrated granule for preventing infection of novel coronavirus and its preparation method |
| WO2023274150A1 (en) * | 2021-06-29 | 2023-01-05 | 山东新时代药业有限公司 | Use of traditional chinese medicine composition in preparation of drug for treating cough variant asthma |
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Application publication date: 20160316 |