CN101869626B - Chinese medicinal compound preparation private care liquid, and preparation and application thereof - Google Patents
Chinese medicinal compound preparation private care liquid, and preparation and application thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal compound preparation private care liquid, and preparation and application thereof. The preparation is prepared from the following raw materials in part by weight: 72 parts of phellodendron, 6 parts of lightyellow sophora root, 6 parts of honeysuckle, 3 parts of swordlike atractylodes rhizome, 3 parts of belvedere fruit, 3 parts of radix rehmanniae recens, 3 parts of common cnidium fruit, 3 parts of cortex dictamni, 18 parts of langdu root, 18 parts of baical skullcap root and 18 parts of parslane herb. The preparation method comprises the following steps: weighing the raw materials, crushing the common cnidium fruit and the swordlike atractylodes rhizome into coarse powder, impregnating the coarse powder for 24 hours by taking a 45 percent ethanol as a solvent, collecting percolate and storing the percolate in a container for later use; and adding water into the other nine raw materials, decocting the mixture twice, for two hours each time, combining decoction, standing the decoction for 48 hours, filtering and concentrating the decoction, dissolving the decoction with the percolate, adjusting the volume of the dissolved decoction with 40 percent ethanol to be 1,000 ml, standing the decoction, taking supernatant and charging the obtained product into packages to obtain the private care liquid. The Chinese medicinal compound preparation private care liquid mainly treats pruritus vulvae, episioitis, eczema of vulva, vaginitis and condyloma acuminatum caused by various germs, and dermatosis caused by various fungi, and has the effects of clearing heat, eliminating toxins, eliminating dampness and relieving itching.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation and preparation thereof and use particularly a kind of compound Chinese medicinal preparation liquid for relaxing yin and preparation thereof and application.
Background technology
At present, mostly the dermopathic Chinese medicine of traditional treatment is prescription prescription handed down from one's ancestors among the people, is the dermopathic Chinese medicine of treatment of monarch drug but Cortex Phellodendri, Radix Sophorae Flavescentis, Flos Lonicerae, Rhizoma Atractylodis are not arranged as yet.
200710029174.0 1 kinds of treatments of patent of invention are by claims second of various germ pruritus vulvaes, vaginitis, cervicitis, eczema scrotum, condyloma acuminatum and various fungus-caused dermopathic medicines, and it is the compound Chinese medicinal preparation of being processed by the following weight proportion raw material: 32 parts of Cortex Phellodendris, 19 parts of Radix Sophorae Flavescentiss, 11 parts of Fructus Cnidiis, 11 parts of Rhizoma Atractylodis, 9 parts of Flos Loniceraes, 6 parts of Cortex Dictamni, 6 parts of the Fructus Kochiae, 6 parts of Radix Rehmanniae.But such prescription is and the immediate technical scheme of the present invention, though this prescription has the various germ vulva prurituss of reasonable treatment, vulvitis, vulval eczema, vaginitis, condyloma acuminatum and various fungus-caused dermopathic effect through the Chinese medicine extraction liquid that obtains after the method for preparing of the present invention.Simultaneously also have the effect of heat-clearing and toxic substances removing, dampness removing to stop itchin, but this Chinese medicine extraction liquid zest is bigger, comfortableness was poor when the patient used.
Summary of the invention
The object of the present invention is to provide compound Chinese medicinal preparation liquid for relaxing yin and preparation thereof and application, this compound Chinese medicinal preparation is the external compound Chinese medicinal preparation, and the pudendum sterilizing that can be used for gynecological cleans.Chinese medicine extraction liquid zest of the present invention is less simultaneously, and comfortableness was good when the patient used.
Technical scheme of the present invention is following:
The compound Chinese medicinal preparation liquid for relaxing yin, it is the compound Chinese medicinal preparation of being processed by the following weight proportion raw material: Cortex Phellodendri 10-60 part, Radix Sophorae Flavescentis 10-30 part; Flos Lonicerae 10-20 part, Rhizoma Atractylodis 10-20 part, Fructus Kochiae 10-20 part; Radix Rehmanniae 10-20 part, Fructus Cnidii 10-20 part, Cortex Dictamni 10-20 part; Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 30-50 part, Radix Scutellariae 30-50 part, Herba Portulacae 30-50 part.Method for making: get above ten simply, Fructus Cnidii, Rhizoma Atractylodis are ground into coarse powder, according to the percolation under fluid extract and the extractum item; Ethanol with 45% is made solvent, floods 24 hours, with the speed of per minute 2～3ml percolation slowly; Collect the percolate of 5 times of amounts, device is deposited subsequent use in addition; Nine flavor decocte with water secondaries such as all the other Cortex Phellodendris, each 2 hours, collecting decoction left standstill 48 hours, filtered, and filtrating is concentrated to the thick paste shape, dissolves with above-mentioned percolate, and adjusts volume to 1000ml with 40% ethanol, leaves standstill 72 hours, gets supernatant, and packing promptly gets.
The compound Chinese medicinal preparation liquid for relaxing yin, wherein: this compound Chinese medicinal preparation is processed by the following weight proportion raw material: 72 parts of Cortex Phellodendris, 6 parts of Radix Sophorae Flavescentiss, 6 parts of Flos Loniceraes; 3 parts of Rhizoma Atractylodis, 3 parts of the Fructus Kochiae, 3 parts of Radix Rehmanniae, 3 parts of Fructus Cnidiis; 3 parts of Cortex Dictamnis, 18 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 18 parts of Radix Scutellariaes, 18 parts of Herba Portulacaes.
The compound Chinese medicinal preparation liquid for relaxing yin, wherein: the method for preparing of this compound Chinese medicinal preparation is: get 72 parts of Cortex Phellodendris, 6 parts of Radix Sophorae Flavescentiss, 6 parts of Flos Loniceraes; 3 parts of Rhizoma Atractylodis, 3 parts of the Fructus Kochiae, 3 parts of Radix Rehmanniae, 3 parts of Fructus Cnidiis; 3 parts of Cortex Dictamnis, 18 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 18 parts of Radix Scutellariaes, Herba Portulacae more than 18 parts ten simply; Fructus Cnidii, Rhizoma Atractylodis are ground into coarse powder,, make solvent, flooded 24 hours with 45% ethanol according to the percolation under fluid extract and the extractum item; With the speed of per minute 2～3ml percolation slowly, collect the percolate of 5 times of amounts, device is deposited subsequent use in addition; Nine flavor decocte with water secondaries such as all the other Cortex Phellodendris, each 2 hours, collecting decoction left standstill 48 hours, filtered, and filtrating is concentrated to the thick paste shape, dissolves with above-mentioned percolate, and adjusts volume to 1000ml with 40% ethanol, leaves standstill 72 hours, gets supernatant, and packing promptly gets.
The compound Chinese medicinal preparation liquid for relaxing yin, wherein: this compound Chinese medicinal preparation is an external preparation.
The preparation of compound Chinese medicinal preparation liquid for relaxing yin, wherein: raw material of the present invention can be and corresponding medicinal adjuvant any one in lotion that conventional technology is processed, suppository, spray, gel, vagina effervescence.
Method for using, consumption, the course of treatment: external, get these article 20ml, add warm water 300ml dilution after, affected part cleaning, once a day.
The present invention cures mainly various germ vulva prurituss, vulvitis, vulval eczema, vaginitis, condyloma acuminatum and various fungus-caused dermatosis.Effect with heat-clearing and toxic substances removing, dampness removing to stop itchin.
Drug matching and the mechanism of curing the disease:
Cortex Phellodendri: hardship, cold.Return kidney, urinary bladder channel.The clearing away heat-fire detoxifcation can be used for the pyretic toxicity card, like the hyperpyrexia of epidemic febrile disease, and skin infection furunculosis etc.Heat clearing and damp drying, the more damp-heat in lower-JIAO that is used for, like damp-heat in the urinary bladder, damp-heat vaginal discharge, the diabrosis of lower limb noxious dampness, eczema is the medicine commonly used of treatment damp-heat in lower-JIAO.Modern pharmacological research: Cortex Phellodendri has tangible antibacterial action to pyococcus, and berberine hydrochloride has bacteriostasis to common dermatophytosis in the Cortex Phellodendri, and is the dose-effect reaction relation.
Radix Sophorae Flavescentis: hardship, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel.Heat clearing and damp drying, parasite killing, diuresis.Be used for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.Modern pharmacological research: Radix Sophorae Flavescentis has antiinflammatory and bacteriostatic functions, and dysentery bacterium, gold-coloured staphylococci, dimension Hakuri Salmonella are all had significant inhibitory effect, and ten various skin funguses such as a beautiful gem color trichophyton are also had inhibitory action in various degree.
Flos Lonicerae: sweet, cold.Return lung, the heart, stomach warp.Heat-clearing and toxic substances removing, wind-heat dissipating.Be used for the carbuncle furuncle, sore throat, erysipelas, warm blood fulminant dysentery, anemopyretic cold, epidemic febrile disease heating.Modern pharmacological research, Flos Lonicerae has broad-spectrum antibacterial action, and pathogenic bacterium such as staphylococcus aureus, dysentery bacterium are had stronger inhibitory action; Obvious anti-inflammatory and anti and refrigeration function are arranged; Water of Flos Lonicerae and steeping in wine liquid have tangible cytotoxicity to sarcoma 180 and ehrlich ascites tumor.
Rhizoma Atractylodis: hardship, temperature.Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold makes eye bright.Be used for distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Modern pharmacological research: Rhizoma Atractylodis have stronger antiulcer action, and its extract has the effect of eliminating drug resistance shigella flexneri R plasmid, can reduce the generation of bacterial drug resistance.
The Fructus Kochiae: cold in nature, acrid in the mouth, hardship.Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.Be used for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.Modern pharmacological research: the Fructus Kochiae has the different bacteriostasis of degree to some dermatophytess, and its water extract has inhibitory action to mouse monokaryon macrophage system and delayed hypersensitivity.
Radix Rehmanniae: sweet, bitter, cold.GUIXIN, liver, lung meridian.Clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Cure mainly YIN damaged by pathogenic heat, the crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, night fever abating at dawn, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, hematemesis and epistaxis, maculopapulae due to toxic heat.Modern pharmacological research: the extract of Radix Rehmanniae can promote solidifying of blood, and decoct also has the liver protecting, prevents the effect that hepatic glycogen reduces, and multiple fungi growth is had inhibitory action.
Fructus Cnidii: warm in nature, acrid in the mouth, hardship.Warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.Be used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.Modern pharmacological research: the osthole in vitro tests has strong activity to the Trichophyton mentagrophytes of Trichophyton.
Cortex Dictamni: bitter cold, go into spleen, the stomach warp.Heat-clearing and toxic substances removing, expelling wind and removing dampness.Be used for diseases such as damp and hot sore, rubella, scabies, skin scratch, arthralgia chiefly caused by damp pathogen, jaundice.Modern pharmacological research: Cortex Dictamni water logging agent is to multiple pathomycete and trichophyton, and Trichophyton concentricunm, oidium schoenleinii all have inhibitory action in various degree, and refrigeration function is arranged.
The Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae): nature and flavor are warm in nature, acrid in the mouth, hardship; Very toxic.Function cures mainly removing water retention by purgation, external hemostasis, antipruritic.Be used for edema, cirrhotic ascites; Wound hemorrhage, tuberculous lymphadenitis, traumatic injury swelling and pain due to blood stasis, skin pruritus, tinea scabies are controlled in external.
Radix Scutellariae: hardship, cold.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Cure mainly diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.
Herba Portulacae: cold in nature, sweet in the mouth acid.Heat-clearing and toxic substances removing, damp eliminating leukorrhagia stopping effect are arranged, be applicable to that damp invasion of lower energizer, leucorrhea with yellow discharge, sticky flavor are smelly, oliguria with yellow urine, thirsty bitter taste, red tongue with yellow fur, rolling pulse person, also can be used for diarrhea due to damp-heat, dysentery etc.Ability anthelmintic effect is applicable to infantile ancylostomiasis.These article have heat-clearing and toxic substances removing, antidiarrheal dysentery, remove intestinal dirt, QI invigorating tonify deficiency effect, are applicable to the treatment chronic dysentery.
Compatibility: the Radix Sophorae Flavescentis with heat clearing and damp drying, wind dispelling insecticide, detoxifcation diuresis in the side is a principal agent." Mingyi Bielu " called it, and " remove the latent heat intestinal and ward off, quench the thirst, sober up, yellowish or reddish urine is treated malignant boil, the bottom." ancient Chinese medicine doctor gets the property of its killing parasites for relieving itching, because of pudendal pruritus swelling of the vulva and the eczema skin pruritus multiple-effect of controlling damp invasion of lower energizer.Be equipped with the Cortex Phellodendri of heat clearing and damp drying, eliminating fire and detoxication, the Flos Lonicerae of heat-clearing and toxic substances removing is an accessory drugs.For Cortex Phellodendri, the record of " main woman's whitish metrorrhagia, negative and positive phagedenoma " is arranged in Shennong's Herbal, " Japan hanako materia medica " also called its " infantile malnutrition worm extremely ", " controlling scabies ".Flos Lonicerae then is a surgery detoxifcation commonly used antipyretic, and it cures mainly " all rheumatism gas reach all toxic swellings, carbuncle, scabies, all malignant boil of Fructus Myricae rubrae " the Compendium of Material Medica meaning.Assistant is with Cortex Dictamni, the Fructus Kochiae of heat-clearing and toxic substances removing, removing damp to relieve itching, the Fructus Cnidii that removing dampness and killing parasites dispels the wind, specially clearing away damp-heat.To Cortex Dictamni, " property of medicine opinion " called its " it is red mashed to control all pyretic toxicity wind, aversion to wind, wind skin ulcer scabies "; This book meaning Fructus Kochiae " go the cloudy ovum disease of bursting, the wind that reduces phlegm and internal heat, soup is taken a shower ", to Fructus Cnidii, " Japan hanako materia medica " mentioned its " go to dry in the shade, exudative dermatitis, toothache, leucorrhea with red and white discharge, fry in shallow oil soup bath strong wind itching over the body ".More than all medicines, close with washout, the function heat clearing and damp drying, detoxifying and relieving itching is controlled to being in step with the skin pruritus that good person's pudendal pruritus, pain over the perineum and scabies etc. cause.
Radix Scutellariae, Herba Portulacae generally are for oral use, generally are not used in external preparation, but Radix Scutellariae, Herba Portulacae use the zest that can alleviate total formulation with other disinfection components matching in the external preparation, improve the comfortableness when using.
We are the hospital preparation of this institute clinical experience side; Year surplus the hospital clinical application existing 10 of Nanchang City andrology; Aim at treatment various germ vulva prurituss, vulvitis, vulval eczema, vaginitis, condyloma acuminatum and establish, and can treat by various fungus-caused dermatosiss.More than each disease, the traditional Chinese medical science belongs to pudendal pruritus, skin pruritus category, its pathogeny is of an identical nature, all with damp and hot be main pathogenesis.The generation that pudendal pruritus is sick, or pudendum is unclean, infects worm; Or indulge in sensual pleasures excessively the funeral kidney qi of hacking; Or feelings will is not relaxed the liver failing to maintain the normal flow of QI; Or spleen do not transport, and interior life is damp and hot; Or eating and drinking without temperance, the delicious food of being addicted to drink: thereby damp invasion of lower energizer, band is appointed in damage, and is foul dirty, itches pain unbearably, and very person's leukorrhagia increases, yellow skin such as pus, or apparent foam water from washing rice appearance, its gas is stench.Primary disease treatment key is heat-clearing and toxic substances removing, dampness removing to stop itchin.
Clinical development standard and clinical effectiveness statistical data:
A, recovery from illness: fungus-caused dermatosis such as various vulvitises is cured fully, and all symptoms all disappear.
B, alleviation fully: can alleviate or alleviate three above persons of cardinal symptom after the medication.
C, part are alleviated: can alleviate or alleviate the above person of cardinal symptom secondary after taking medicine.
D, stable: medication one all above state of an illness do not have being clearly better or worsen.
E, progress: medication is after ten days, and symptom is not felt any better, and the state of an illness is failed controlled, and dermatosis symptoms such as pruritus vulvae, eczema, vulvitis are more serious.
Case 68 examples are observed in treatment altogether.According to above-mentioned treatment standard rating, meeting A has 52 examples, accounts for 76.47%, and B has 11 examples, accounts for 16.17%, and C has 4 examples, accounts for 5.88%, and D has 1 example to account for 1.47%, and E has 0 example to account for 0%.In observing case, according to curative effect determinate standard.A, B, C are that effectively D, E are invalid.Its effective percentage is 98.53%.
The specific embodiment
Embodiment 1, compound Chinese medicinal preparation liquid for relaxing yin, it is the compound Chinese medicinal preparation of being processed by the following weight proportion raw material: 72 parts of Cortex Phellodendris, 6 parts of Radix Sophorae Flavescentiss, 6 parts of Flos Loniceraes; 3 parts of Rhizoma Atractylodis, 3 parts of the Fructus Kochiae, 3 parts of Radix Rehmanniae, 3 parts of Fructus Cnidiis; 3 parts of Cortex Dictamnis, wherein: the method for preparing of this compound Chinese medicinal preparation is: get above eight flavors, Fructus Cnidii, Rhizoma Atractylodis are ground into coarse powder; According to the percolation under fluid extract and the extractum item, make solvent with 45% ethanol, flooded 24 hours; With the speed of per minute 2～3ml percolation slowly, collect the percolate of 5 times of amounts, device is deposited subsequent use in addition; Nine flavor decocte with water secondaries such as all the other Cortex Phellodendris, each 2 hours, collecting decoction left standstill 48 hours; Filter, filtrating is concentrated to the thick paste shape, dissolves with above-mentioned percolate, and adjusts volume to 1000ml with 40% ethanol; Left standstill 72 hours, and got supernatant, packing promptly gets Chinese medicine extraction liquid A.
Embodiment 2, compound Chinese medicinal preparation liquid for relaxing yin, it is the compound Chinese medicinal preparation of being processed by the following weight proportion raw material: 72 parts of Cortex Phellodendris, 6 parts of Radix Sophorae Flavescentiss, 6 parts of Flos Loniceraes; 3 parts of Rhizoma Atractylodis, 3 parts of the Fructus Kochiae, 3 parts of Radix Rehmanniae, 3 parts of Fructus Cnidiis; 3 parts of Cortex Dictamnis, 18 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 18 parts of Radix Scutellariaes, 18 parts of Herba Portulacaes.Wherein: the method for preparing of this compound Chinese medicinal preparation is: get above ten simply; Fructus Cnidii, Rhizoma Atractylodis are ground into coarse powder,, make solvent with 45% ethanol according to the percolation under fluid extract and the extractum item; Flooded 24 hours; With the speed of per minute 2～3ml percolation slowly, collect the percolate of 5 times of amounts, device is deposited subsequent use in addition; Seven flavor decocte with water secondaries such as all the other Cortex Phellodendris, each 2 hours, collecting decoction left standstill 48 hours; Filter, filtrating is concentrated to the thick paste shape, dissolves with above-mentioned percolate, and adjusts volume to 1000ml with 40% ethanol; Left standstill 72 hours, and got supernatant, packing promptly gets Chinese medicine extraction liquid B.
Embodiment 3, compound Chinese medicinal preparation liquid for relaxing yin; The compound Chinese medicinal preparation prescription that raw material is processed is with reference to seeing claims second of 200710029174.0 1 kinds of treatments of patent of invention by various germ pruritus vulvaes, vaginitis, cervicitis, eczema scrotum, condyloma acuminatum and various fungus-caused dermopathic medicines; It is the compound Chinese medicinal preparation of being processed by the following weight proportion raw material: 32 parts of Cortex Phellodendris, 19 parts of Radix Sophorae Flavescentiss, 11 parts of Fructus Cnidiis, 11 parts of Rhizoma Atractylodis, 9 parts of Flos Loniceraes, 6 parts of Cortex Dictamni, 6 parts of the Fructus Kochiae, 6 parts of Radix Rehmanniae; Wherein: the method for preparing of this compound Chinese medicinal preparation is: get above eight flavors; Fructus Cnidii, Rhizoma Atractylodis are ground into coarse powder, according to the percolation under fluid extract and the extractum item, make solvent with 45% ethanol; Flooded 24 hours; With the speed of per minute 2～3ml percolation slowly, collect the percolate of 5 times of amounts, device is deposited subsequent use in addition; Nine flavor decocte with water secondaries such as all the other Cortex Phellodendris, each 2 hours, collecting decoction left standstill 48 hours; Filter, filtrating is concentrated to the thick paste shape, dissolves with above-mentioned percolate, and adjusts volume to 1000ml with 40% ethanol; Left standstill 72 hours, and got supernatant, packing promptly gets Chinese medicine extraction liquid C.
Liquid for relaxing yin is tested skin irritation:
Chinese medicine: with Cortex Phellodendri, Radix Sophorae Flavescentis, Flos Lonicerae, Rhizoma Atractylodis, the Fructus Kochiae, Radix Rehmanniae; Fructus Cnidii, the Chinese medicine extraction liquid A that Cortex Dictamni eight flavor Chinese medicines form through the extraction processing and preparing, with Cortex Phellodendri, Radix Sophorae Flavescentis, Flos Lonicerae; Rhizoma Atractylodis, the Fructus Kochiae, Radix Rehmanniae, Fructus Cnidii, Cortex Dictamni; The Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Radix Scutellariae, Herba Portulacae ten simply Chinese medicine through extracting the Chinese medicine extraction liquid B that processing and preparing forms, to be different from the Cortex Phellodendri of Chinese medicine extraction liquid A content prescription, Radix Sophorae Flavescentis, Fructus Cnidii; Rhizoma Atractylodis, Flos Lonicerae, Cortex Dictamni, the Fructus Kochiae, Radix Rehmanniae eight flavor Chinese medicines are through extracting the Chinese medicine extraction liquid C that processing and preparing forms; Liquid for relaxing yin is mainly used in the disease of itching of sending of women's pudendum, also can consider the safety for mucosa at ordinary times or menstruation care, and we have carried out the zest contrast test to it, existing report as follows:
Test material
Animal: rabbit 2.2～2.6kg, ♂ ♀ dual-purpose.
The source: the animal testing center, Jiangxi provides.
Medicine: Chinese medicine extraction liquid A, Chinese medicine extraction liquid B, Chinese medicine extraction liquid C.
Test method
(1) skin irritation test
Get healthy rabbits, per 16 is one group, and many group experiments are set; Preceding 24 hours of intact skin administration is 10% of the about surface area of tame rabbit back two side skin QUMAO, and the diluent gradation of Chinese medicine extraction liquid A is applied on the skin of rabbit, and opposite side is coated with 50% ethanol and compares; Remove residual medicinal liquid after 6 hours; 1 hour, 24 hours, the inspection medicine was to the IR of rabbit skin in 48 hours.
Chinese medicine extraction liquid A, Chinese medicine extraction liquid B are to the skin irritation reaction result:
| Erythematous response progression | Chinese medicine extraction liquid A is to producing the influence of erythema | Chinese medicine extraction liquid B is to producing the influence of erythema | Chinese medicine extraction liquid C is to producing the influence of erythema |
| The intact skin of 0 no erythema | 8 | 14 | 7 |
| 1 slight erythema | 3 | 1 | 3 |
| 2 moderate erythema | 3 | 1 | 4 |
| 3 severe erythema | 1 | 0 | 2 |
| 4 severe erythema are to slight eschar | 1 | 0 | 0 |
| The edema order of reaction | Chinese medicine extraction liquid A is to producing the influence of edema | Chinese medicine extraction liquid B is to producing the influence of edema | Chinese medicine extraction liquid C is to producing the influence of edema |
| 0 anhydrous bullate intact skin | 7 | 13 | 8 |
| 1 Mild edema (visible reluctantly) | 5 | 3 | 4 |
| 2 slight edema (profile raised panel is clear) | 4 | 0 | 4 |
| 3 intermediate edema | 0 | 0 | 0 |
| 4 severe edemas | 0 | 0 | 0 |
The result: Chinese medicine extraction liquid B is qualified to the skin irritation reaction, and erythema, eschar or edema phenomenon are not seen.Chinese medicine extraction liquid A and Chinese medicine extraction liquid C are bigger to the zest of skin, still see a spot of erythema is arranged, eschar or edema phenomenon, Chinese medicine extraction liquid A and Chinese medicine extraction liquid C are not ideal to the skin irritation reaction.Chinese medicine extraction liquid B is qualified to skin irritation reaction, not only helps easy to usely, to reducing medicine the stimulation of skin is had contribution.
Claims (4)
1. compound Chinese medicinal preparation liquid for relaxing yin, it is characterized in that: it is the compound Chinese medicinal preparation of being processed by the following weight proportion raw material: Cortex Phellodendri 10-60 part, Radix Sophorae Flavescentis 10-30 part; Flos Lonicerae 10-20 part, Rhizoma Atractylodis 10-20 part, Fructus Kochiae 10-20 part; Radix Rehmanniae 10-20 part, Fructus Cnidii 10-20 part, Cortex Dictamni 10-20 part; Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 30-50 part, Radix Scutellariae 30-50 part, Herba Portulacae 30-50 part.
2. compound Chinese medicinal preparation liquid for relaxing yin, it is characterized in that: this compound Chinese medicinal preparation is processed by the following weight proportion raw material: 72 parts of Cortex Phellodendris, 6 parts of Radix Sophorae Flavescentiss; 6 parts of Flos Loniceraes, 3 parts of Rhizoma Atractylodis, 3 parts of the Fructus Kochiae; 3 parts of Radix Rehmanniae, 3 parts of Fructus Cnidiis, 3 parts of Cortex Dictamnis; 18 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 18 parts of Radix Scutellariaes, 18 parts of Herba Portulacaes.
3. the method for preparing of compound Chinese medicinal preparation liquid for relaxing yin is characterized in that: get Cortex Phellodendri 10-60 part, Radix Sophorae Flavescentis 10-30 part, Flos Lonicerae 10-20 part; Rhizoma Atractylodis 10-20 part, Fructus Kochiae 10-20 part, Radix Rehmanniae 10-20 part, Fructus Cnidii 10-20 part; Cortex Dictamni 10-20 part, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 30-50 part, Radix Scutellariae 30-50 part, Herba Portulacae 30-50 part above ten is simply; Fructus Cnidii, Rhizoma Atractylodis are ground into coarse powder,, make solvent, flooded 24 hours with 45% ethanol according to the percolation under fluid extract and the extractum item; With the speed of per minute 2～3ml percolation slowly, collect the percolate of 5 times of amounts, device is deposited subsequent use in addition; Nine flavor decocte with water secondaries such as all the other Cortex Phellodendris, each 2 hours, collecting decoction left standstill 48 hours, filtered, and filtrating is concentrated to the thick paste shape, dissolves with above-mentioned percolate, and adjusts volume to 1000ml with 40% ethanol, leaves standstill 72 hours, gets supernatant, and packing promptly gets.
4. compound Chinese medicinal preparation liquid for relaxing yin as claimed in claim 2 is characterized in that: it is an external preparation.
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| CN103169902B (en) * | 2011-12-20 | 2014-12-31 | 上海中医药大学附属曙光医院 | Application of traditional Chinese medicine combination in preparation of medicine for treating viral warts |
| CN103191355B (en) * | 2013-04-12 | 2014-06-18 | 杨邱月 | Traditional Chinese medicine preparation for treating pruritus vulvae and preparation method of traditional Chinese medicine preparation |
| CN103638229A (en) * | 2013-12-05 | 2014-03-19 | 青岛友铭辰生物技术有限公司 | Chinese medicinal lotion for treating eczema and preparation method thereof |
| CN104547812A (en) * | 2014-12-31 | 2015-04-29 | 李福美 | Traditional Chinese medicine flushing agent for treating verruca acuminata and preparation method of traditional Chinese medicine flushing agent |
| CN105535723A (en) * | 2015-12-25 | 2016-05-04 | 柴华 | Traditional Chinese medicinal composition for treating vulvitis and external preparation of traditional Chinese medicinal composition |
| CN107789449A (en) * | 2016-08-30 | 2018-03-13 | 天津太平洋制药有限公司 | A kind of medicine for treating eczema and preparation method thereof |
| CN106619780A (en) * | 2017-02-24 | 2017-05-10 | 李忠泽 | Gynecological antibacterial gel |
| CN107412617A (en) * | 2017-08-07 | 2017-12-01 | 于瑞霞 | A kind of Chinese medicine composition for treating pregnant eczema of vulva and preparation method thereof |
| CN114177252A (en) * | 2021-12-06 | 2022-03-15 | 吴玉宝 | Anti-bacterial ointment for Arabrother and preparation method thereof |
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| CN1086724A (en) * | 1993-08-04 | 1994-05-18 | 李社伦 | Atomized pudendal cleaning liquid |
| CN101347541A (en) * | 2007-07-16 | 2009-01-21 | 陆荣政 | Medicament for treating gynecology disease and dermatopathy and preparation thereof |
| CN101648003A (en) * | 2008-08-13 | 2010-02-17 | 北京和润创新医药科技发展有限公司 | Medicinal composition for treating gynecological inflammation and application thereof |
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| CN1086724A (en) * | 1993-08-04 | 1994-05-18 | 李社伦 | Atomized pudendal cleaning liquid |
| CN101347541A (en) * | 2007-07-16 | 2009-01-21 | 陆荣政 | Medicament for treating gynecology disease and dermatopathy and preparation thereof |
| CN101648003A (en) * | 2008-08-13 | 2010-02-17 | 北京和润创新医药科技发展有限公司 | Medicinal composition for treating gynecological inflammation and application thereof |
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