CN102631648A - Chinese patent medicine for treating acute urticaria - Google Patents

Abstract

The invention discloses a Chinese patent medicine for treating acute urticaria, belonging to the technical field of treatment medicines of urticaria. The Chinese patent medicine is characterized by being prepared from the following medicines in parts by weight: ephedra, dried ginger, common ducksmeat herb, almonds, densefruit pittany root-bark, salvia miltiorrhiza, tangerine peel, tree peony root bark, stiff silkworms, fineleaf schizonepeta herb, divaricate saposhnikovia root, honeysuckle, great burdock achene, radix rehmanniae, radix scutellariae, mint, cicada slough, angelica, peony root, folium isatidis and licorice roots northwest origin. Compared with the prior art, the Chinese patent medicine for treating acute urticaria can eliminate diseases of patients and promote physical and psychological health and simultaneously has the prominent substantive characteristics and remarkable progresses of low treatment cost, convenience for patients to take, quick effect and no side effect.

Description

A kind of Chinese patent medicine of treating acute urticaria

Technical field

The present invention relates to urticaria treatment of diseases field of pharmaceutical technology, relate in particular to a kind of technical field that is used to treat urticarial Chinese patent medicine.

Background technology

Urticaria is commonly called as welt, rubella group, wind pimple, rubella wheal, is that a kind of common skin is sick.This sick erythra performance has contacted the plant Herba Urticae Cannabinae just as the people, and the skin lesion that is caused is similar, so be called urticaria.These sick characteristics are: the skin lesion of general property of whole body welt type, and erythra is made a return journey rapidly, and disappearing leaves no trace, and conscious itching very can be with General Symptoms and visceral lesion, like fever, stomachache, diarrhoea or other General Symptomies.Be divided into acute urticaria, chronic urticaria, vasodilation and pimple shape urticaria etc., normal touchingly do not heal for many years; Pathogenic factor: some food, medicine, infection, pollen and other inhalation (inhalatio)s (room dirt, animal scurf etc.), and Nervous and Mental Factors, physical factor, systemic disease, heredodiathesis etc. also can become the reason that Herba Urticae Cannabinae is examined morbidity.Urticaria is a kind of common skin, the mucosa vascular reactivity disease due to the multiple different reason.Be characteristic with the limitation of skin, mucosa, temporary, pruritus sexflush speckle and welt clinically.Its pathogeny can be immunity with non-immune, the common cause of disease of urticaria has: (1) food and additive; (2) medicine; (3) infect; (4) animal, plant and inhalation (inhalatio); (5) physical factor; (6) viscera disease; (7) Nervous and Mental Factors; (8) inherited genetic factors.By cause of disease classification many specific types are arranged.How to distinguish diagnosis and treatment clinically at present with histamine type and cholinergic type.The primary disease cause of disease is complicated, and modern medicine is thought, with body is irritated to some material, the generation allergy is relevant.

Urticaria is grabbed the back erubescence from the beginning of local skin generation pruritus, and shape immediately takes place to differ, the scarlet or white welt that differs in size, violent pruritus is risen one after another, and can show effect within one day for several times.General general whole body of erythra, mucosal sites also can be got involved, and betides gastrointestinal tract and can betide the larynx mucosa with stomachache, diarrhoea, can cause that then laryngeal edema produces dyspnea, chest distress, but severe patient death by suffocation.Send out the author repeatedly, can delay several months or several years.Brought more serious wrecking to patient's body, its weak curative effect, outbreak makes the patient dissatisfied repeatedly, has not only brought many miseries to the patient, and has brought higher medical expense.Therefore, seek a kind of illness new, that can eliminate the patient, have take medicine conveniently, problem that curative effect is fast, the urticarial Chinese patent medicine of treatment that have no side effect is still the present technique field technical staff needs to be resolved hurrily.

Summary of the invention:

Technical problem to be solved by this invention is the deficiency that overcomes prior art; And provide a kind of to eliminate patient's illness; Promote physically and mentally healthy, the Chinese patent medicine of the treatment acute urticaria that have simultaneously that medical expense is low, the patient takes medicine conveniently, curative effect is fast, has no side effect.

For solving the problems of the technologies described above; The present invention adopts following technical scheme: a kind of Chinese patent medicine of treating acute urticaria, its special character is to be prepared from following medicaments in part by weight: Herba Ephedrae 3-10 part, Rhizoma Zingiberis 3-10 part, Herba Spirodelae 5-20 part, Semen Armeniacae Amarum 5-20 part, Cortex Dictamni 10-30 part, Radix Salviae Miltiorrhizae 10-30 part, Pericarpium Citri Reticulatae 5-25 part, Cortex Moutan 5-25 part, Bombyx Batryticatus 5-20 part, Herba Schizonepetae 5-20 part, windproof 5-20 part, Flos Lonicerae 10-30 part, Fructus Arctii 5-20 part, Radix Rehmanniae 5-20 part, Radix Scutellariae 5-20 part, Herba Menthae 3-10 part, Periostracum Cicadae 3-10 part, Radix Angelicae Sinensis 5-20 part, Radix Paeoniae Rubra 5-20 part, Folium Isatidis 5-20 part, Radix Glycyrrhizae 3-10 part.

For further solving the problems of the technologies described above, the preferred version of said medicine weight portion is: Herba Ephedrae 5-8 part, Rhizoma Zingiberis 5-8 part, Herba Spirodelae 10-15 part, Semen Armeniacae Amarum 10-15 part, Cortex Dictamni 15-25 part, Radix Salviae Miltiorrhizae 15-25 part, Pericarpium Citri Reticulatae 10-20 part, Cortex Moutan 10-20 part, Bombyx Batryticatus 10-15 part, Herba Schizonepetae 10-15 part, windproof 10-15 part, Flos Lonicerae 15-25 part, Fructus Arctii 10-15 part, Radix Rehmanniae 10-15 part, Radix Scutellariae 10-15 part, Herba Menthae 5-8 part, Periostracum Cicadae 5-8 part, Radix Angelicae Sinensis 10-15 part, Radix Paeoniae Rubra 10-15 part, Folium Isatidis 10-15 part, Radix Glycyrrhizae 5-8 part.

For further solving the problems of the technologies described above, the preferred plan of said medicine weight portion is: 6.5 parts in Herba Ephedrae, 6.5 parts of Rhizoma Zingiberiss, 12 parts in Herba Spirodelae, 12 parts in Semen Armeniacae Amarum, 20 parts of Cortex Dictamnis, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Cortex Moutans, 12 parts of Bombyx Batryticatus, 12 parts of Herba Schizonepetae, windproof 12 parts, 20 parts of Flos Loniceraes, 12 parts of Fructus Arctiis, 12 parts in the Radix Rehmanniae, 12 parts of Radix Scutellariaes, 6.5 parts of Herba Menthaes, 6.5 parts of Periostracum Cicadaes, 12 parts of Radix Angelicae Sinensis, 12 parts of Radix Paeoniae Rubra, 12 parts of Folium Isatidiss, 6.5 parts of Radix Glycyrrhizae.

Above-mentioned described Chinese patent medicine is processed the oral medicine dosage form of pill, sublimed preparation, powder, tablet, unguentum, decoction and capsule dress powder according to the conventional technology of preparing of Chinese medicine.

Above-mentioned described Chinese patent medicine also contains drug excipient.

Above-mentioned described Chinese patent medicine is used for the application as the dermopathic Chinese patent medicine for oral administration of treatment acute urticaria.

The principles of formulating prescriptions of Chinese patent medicine of the present invention are: regulating the blood flow circulation, painful antipruritic, the cooling blood and dissolving purpura of clearing away heart-fire, expelling wind and removing dampness, kidney tonifying detoxifcation, town, enhancement telangiectasis improve immune function of human body, thereby reach the purpose of treatment acute urticaria.The present invention has proper, the reasonable recipe of compatibility of drugs, and the effect of its said each herbal medicine is:

Herba Ephedrae: be the dry herb stem of Ephedraceae plant plait Herba Ephedrae, epheday intermedia or ephedra equisetina.Main component is an alkaloid, and wherein L-ephedrine, D-pseudoephedrine are its main active, also contain the volatilization wet goods, and Herba Ephedrae acrid in the mouth, little hardship are warm in nature.Return lung, urinary bladder channel.The effect of have relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing and inducing diuresis to remove edema, analgesic, antiinflammatory antitussive, eliminating the phlegm;

Rhizoma Zingiberis: choose clean impurity, be soaked in water 3～6 hours, pull out, vexed, cut into slices after the profit or dice, dry.Acrid in the mouth, hot in nature, big heat, nontoxic; Return spleen, stomach, lung meridian; Effect: warming middle-JIAO is by cold, and recuperating depleted YANG is promoted blood circulation; Cure mainly trusted subordinate's cold type of pain, vomit and diarrhoea, the cold extremities faint pulse is breathed with cough for cold time, anemofrigid-damp arthralgia, and yang deficiency is told, nosebleed, hematochezia.

Herba Spirodelae: acrid in the mouth, cold in nature.Nontoxic.Go into lung, liver, spleen channel.Effect: diaphoresis, dispel the wind row water, heat clearing away, detoxifcation.Cure mainly: the hot carbuncle of row when controlling, macule is not passed through, wind heat pain rash, skin pruritus, edema, amenorrhea, the skin ulcer tinea, erysipelas is scalded.

Semen Armeniacae Amarum: choose clean impurity, put the boiling water part omitted and boil, soak in the cold water, slough kind of a skin, dry, it is clean to winnow with a dustpan.Stir-baked SEMEN ARMENIACAE AMARUM: get clean Semen Armeniacae Amarum and put in the pot and fry to little yellow with slow fire, taking-up cools.Bitter in the mouth, warm in nature, poisonous, be included into lung, large intestine channel; Have expelling phlegm for arresting cough, relieving asthma, the effect of intestine moistening; Cure mainly the exogenous cough, dyspnea with fullness of the chest, sore throat, diseases such as dryness of the intestine constipation.

Cortex Dictamni: cold in nature, bitter in the mouth, return spleen, stomach, bladder, small intestine meridian; Effect is a heat clearing and damp drying, dispels the wind detoxifcation; The clinical damp and hot sore, pus all over nest, yellow fluid of being used for is dripping; And skin pruritus, skin ulcer tinea mange, pudendum disease, Cortex Dictamni such as swell and ache is to dispel the wind, remove damp and hot medicine; And but eliminating dampness by diuresis heat is applicable to diseases such as skin ulcer tinea pruritus due to damp pathogen in lower orifices, often cooperates medicines such as Radix Sophorae Flavescentis, the Fructus Kochiae with using; Both oral administration also can be fried in shallow oil the soup washout.

Radix Salviae Miltiorrhizae: bitter in the mouth, little suffering, cold nature; Go into the heart, spleen, liver, kidney footpath; Effect: have blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind, removing heat from blood repercussive effect; Cure mainly: blood stasis head, breast, the side of body, abdomen pain, gather, menoxenia, the dysmenorrhea amenorrhea, the stasis of blood stagnated and suffered from abdominal pain puerperal, arthralgia, the traumatic injury congestive edema, epidemic febrile disease is vexed, palpitation due to deficiency of blood, sore swollen toxin, red rash scabies.

Pericarpium Citri Reticulatae: warm in nature, bitter in the mouth, suffering.Function cures mainly, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough ant phlegm.

Cortex Moutan: bitter in the mouth, cool in nature, be slightly cold.GUIXIN, liver, kidney, lung meridian.Effect cures mainly: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and pounce on the pain of injury; The rheumatism pyretic arthralgia.

Bombyx Batryticatus: acrid in the mouth, salty, property is flat, has expelling wind to relieve convulsion, dissipating phlegm and resolving masses, the effect of heat-clearing and toxic substances removing dampness clinically is used to control heat syndrome cough more, and phlegm dyspnea is spitted blood, collapses, band, traumatic injury, rheumatalgia, sore etc., its range of application and field constantly enlarge in recent years.

Herba Schizonepetae: acrid in the mouth, slightly warm in nature, return lung, Liver Channel, have the diffusing wind that induces sweat, rash, the skin ulcer that disappears, hemostatic effect, be usually used in treatment flu, measles pass through send out smooth, have blood in stool, diseases such as metrorrhagia, epistaxis.

Windproof: as acrid in the mouth, sweet, slightly warm in nature, to return bladder, liver, spleen channel, have the effect of expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion, be used to treat diseases such as diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.

Flos Lonicerae: another name: Flos Lonicerae, little egret flower, Flos Lonicerae, Flos Lonicerae, Flos Lonicerae, golden rattan, two bud flower, JINHUA, two precious flowers; Cold in nature, sweet in the mouth; Gui Jing: lung; Stomach is through effect: heat-clearing and toxic substances removing cures mainly: the epidemic febrile disease heating; Toxic-heat and blood stasis; The carbuncle furuncle; Sore throat and multiple infectious disease.

Fructus Arctii: remove impurity, cleaning, drying.Acrid in the mouth, hardship, cold in nature; Attach to the lung and stomach meridians; Has dispelling wind and heat pathogens, lung qi dispersing rash, the effect of resolving toxin and disinhibiting the throat; Be used for anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, the treatment of diseases such as carbuncle sore tumefacting virus.

The Radix Rehmanniae: Radix Rehmanniae sweet in the mouth, hardship, cold in nature.GUIXIN, liver, lung meridian.Function cures mainly: has the clearing away heat and cooling blood effect, is used for the warm febrile disease blood of joining the army, and the high fever coma, dry tongue is deep red; Control the epidemic febrile disease later stage, waste heat to the greatest extent, do not hinder, night fever abating at dawn, red tongue rapid pulse person by cloudy liquid; Can be used for controlling the warm febrile disease blood of joining the army, the heat in blood poison is contained, hematemesis and epistaxis, and macule is purple black; The YIN nourishing and the production of body fluid promoting effect.It is thirsty also to can be used for Tianjin wound, and interior-heat is quenched one's thirst, and controls the epidemic febrile disease impairment of YIN, the dryness of the intestine constipation.

Radix Scutellariae: Radix Scutellariae another name Radix Scutellariae, tsuchikane tea root.For the labiate Radix Scutellariae, be used as medicine with root.Heat clearing and damp drying is arranged, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.

Herba Menthae: remove old stem and impurity, slightly spray clear water, moisten slightly, the section of prescinding, cold drying in time.Mostly these article are the short section of 5～8mm, blackish green, purple brown or taupe; Acrid in the mouth, cool in nature is returned lung, Liver Channel; Has dispelling wind-heat.The refresh oneself, the effect of rash; Be mainly used in anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, the treatment of diseases such as breast side of body feeling of distension and oppression.

Cicada: Alias: cicada back, Chan Yi, insects slough, cicada shells, grasshopper Liao skin, cicada skin, Taurus child, the product is black grasshopper insect cicada eclosion larvae off of the hull.Summer, Qiu Erji collect, and remove silt, dry, and these article body is light, and hollow is frangible.Odorless, lightly seasoned; Property is sweet, flavor is cold, returns lung, Liver Channel; Have diffusing wind heat extraction, sore-throat relieving, rash, nebula removing, the effect of spasmolytic is used for anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta, convulsion with spasms, diseases such as tetanus.

Radix Angelicae Sinensis: hot, the little hardship, warm in nature of sweet in the mouth, return liver spleen heart channel, having enriches blood invigorate blood circulation he, the effect of menstruction regulating and pain relieving, these the article diseases such as row is stagnant, menstruction regulating and pain relieving of can nourishing blood with the Rhizoma Chuanxiong compatibility;

Radix Paeoniae Rubra: sour in the mouth, hardship, cool in nature.Go into liver, spleen channel.Effect: clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control the stagnant amenorrhea of the stasis of blood, the hernia abdominal mass is gathered, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle.

Folium Isatidis: another name indigo leaf, southern Baphicacanthus cusia leaf, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) leaf, these article are the dried leaves of cruciferae isatis.Divide in summer, two seasons of autumn and gather for 2～3 times, remove impurity, dry.Bitter in the mouth, cold in nature, GUIXIN, stomach warp; Effect: clearing away heat and cooling blood, detoxifcation.Cure mainly: epidemic encephalitis type B, influenza, mumps, upper respiratory tract infection, pneumonia, acute hepatitis, calentura is sent out speckle, erysipelas, furuncle swelling toxin, diseases such as venom.

Radix Glycyrrhizae: be the pulse family herbaceos perennial.Sweet in the mouth, property is flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Tcm theory is thought: acute urticaria is because " institute of heresy gathers, and its gas must be empty " institute causes.Because the human righteousness is weak relatively, and patient's body constitution is different, or in dyspepsia, pathogenic heat are arranged, feel the heresy of wind and cold, wind heat again; Or weak usually, deficiency of YIN-blood, erythra is shown effect repeatedly, does not prolongedly heal, and QI and blood is consumed; Or suffer from chronic disease (like celiosite, hepatitis, nephritis, menoxenia etc.) must not catharsis in causing, must not reach thoroughly outward, strongly fragrant between the skin space between skin and muscles, evil quadrature is striven and is fallen ill.Be mainly in the women clinically, especially with the young and the middle aged for seeing more, be prone to the key factor that becomes to bring out, and pathogenic feelings are shown effect repeatedly.In a word, feelings will internal injury, ailment said due to cold or exposure invasion and attack are risk factors of primary disease morbidity, and nutrient blood is become estranged, passages through which vital energy circulates loses and dredges, coagulation of QI-blood then is its pathogenesis.Therefore,

Chinese patent medicine of the present invention is followed the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", all compositions come from " the 5th edition medicine that records of Chinese pharmacopoeia, all medicines mutually with have temperature compensation liver spleen altogether; The wind dehumidifying of loosing, the QI and blood regulating, is set upright and is got rid of evils dredge the meridian passage, blood circulation promoting and blood stasis dispelling; Regulate immunologic function, improve skin microcirculation, reach treatment and prevention urticaria, determined curative effect; Have no side effect various Chinese medicine preparation taking conveniences.

The clinical result of use of Chinese patent medicine of the present invention shows to have following advantage:

1, the Chinese medicine each component selected for use of Chinese patent medicine of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment urticaria disease of the Chinese medicine of respectively distinguishing the flavor of, and is harmless to human non-toxic.Acute toxicity test and accumulation toxicity test through white mice and rat show that underproof animal does not see any toxic reaction; Compare zero difference through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group, prove that its safety of medicine is reliable.

2, Chinese patent medicine preparation of the present invention need not decoct, not have bitterness sense; Rich in proteins, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid in the medicine; Also contain various trace elements such as Saponin, plant sterol, calcium; Help absorption of human body, health invigorating, and taking convenience.

But 3, Chinese patent medicine preparation of the present invention efficacious therapy acute urticaria disease not only; And it is also very obvious to the preventive effect of urticaria disease; Particularly pass through working in coordination with each other between the medicine, strengthen medicine and treat characteristic separately, through dredge the meridian passage and adjusting immunologic function; Improve the intrinsic healthy energy of patient body and physical and mental health and life quality, reached the healing rehabilitation efficacy preferably.

Further specify the effect of Chinese patent medicine of the present invention through clinical practice below to the treatment acute urticaria.

One, clinical diagnosis standard:

Acute urticaria is the localized edema reaction that a kind of little vasodilation of skin mucosa that is caused by Different types of etiopathogenises, permeability increase.In urticaria, whole scytitis system is activated, and therefore, in the pathogenesis of acute urticaria, except clear and definite histamine, other mediators also play synergism.Acute eczema, morbidity is rapid, and erythra is pleomorphism; Mainly show as pimple, papulovesicle, vesicle, erosion on the erythema edema basis, ooze out, incrustation etc., can general whole body when serious, acute pruritus.The acute urticaria appearance vasculitis welt persistent period reaches 24～72 hours, with heating, arthralgia, erythrocyte sedimentation rate speed, hypocomplementemia, pathologic finding is that the brokenness vasculitis changes.During with symptoms such as vomiting, diarrhoea, stomachache, should differentiate with gastroenteritis and some acute abdomen.Its standard has:

1. the skin welt appearance infringement that occurs differing in size takes place suddenly, disappears rapidly, and acute pruritus leaves no trace after more.

2. urticaria, welt infringement outbreak repeatedly, time remaining is more than 1～3 month.

3. lab testing, the skin allergy source inspection can be found positive findings; Serum levels increases.

Differential Diagnosis:

1, differentiates with infantile eczema

Infantile eczema is meant and betides the infantile eczema characteristics skin lesion that has.Infantile eczema can comprise infantile atopic dermatitis, baby's contact dermatitis, baby's seborrhea property and intertrigo dermatitis, and urticaria can not be equal to or replace.

2, differentiate with angioedema

Angioedema is chronic recurrent corium deep layer and hypodermic large stretch of locality edema.The cause of disease and pathogenesis are identical with urticaria, and just blood plasma is from corium deep or hypodermic little vascular endothelial cell gap, to ooze out, and enter on every side in the open texture to cause.

3, differentiate with gastroenteritis and some acute abdomen

The urticaria appearance vasculitis welt persistent period reaches 24～72 hours, with heating, arthralgia, erythrocyte sedimentation rate speed, hypocomplementemia, pathologic finding is that the brokenness vasculitis changes.During with symptoms such as vomiting, diarrhoea, stomachache, should differentiate with gastroenteritis and some acute abdomen.

Traditional Chinese medical science class card is differentiated:

1. natural conditions and social customs of a place skin ulcer: be more common in children's, the spring and autumn of being everlasting morbidity, good sending out in trunk and extremity near-end shows as in life Mi Daxiao spindle like welt appearance erythra, and vesicle can appear in the center, even bulla, blood blister disappeared in 5～10 days.

2. pigment property urticaria: the welt back that disappears is lost yellowish-brown or brown pigmented spots is arranged, through scratch or other mechanical stimuluss after can recur.

3. erythema multiforme: typical skin lesion in the form of a ring or the rainbow shape, its color is dark red or purplish red.

Acute urticaria inspection chemical examination:

According to the recurrent welt of skin, play is itched, and step back to leave no trace, and various urticarial characteristics etc. is easy to diagnosis.But should differentiate mutually in following disease.The lab testing (comprising chest X-ray Abdominal B type ultrasonography etc.) of going in case of necessity reaches relevant test (like motion, hot water, daylight, ice cube), allergen detection etc. and further to define the cause of disease.Diagnosis is had any problem or further will be sought the cause of disease and can carry out following lab testing like clinical symptoms.

1. doubt and can check erythrocyte sedimentation rate, antinuclear antibody etc. for rheumatism causes urticaria person, SC is measured, skin biopsy is helpful to there being complement activation to participate in the urticariogenic diagnosis of institute.

2. Porges be should check to cold urticaria, cryoglobulin, CF, cold hemolysin and inspections such as ice cube test, antinuclear antibody measured.

3. solar urticaria should be checked excrement, uroporphyrin etc., should note distinguishing mutually with SLE.

4. doubt and infect relevantly, or there are the hepatitis history in hepatomegaly or medical history, feasible routine blood test, hepatitis B antigen, antibody inspection, the inspections such as worm's ovum, fungus, lesions position X line of defecating during health check-up.

5. there is thyroid disease should make anti-microsome thyroid antibody coherence check as suspecting.

6. as suspecting suction or eating allergy sufferers, the allergen of should going inspection is like the positive desensitization treatment of doing.

7. the serum sickness urticaria patient has heating and arthralgia, should check erythrocyte sedimentation rate, normally has important diagnostic to be worth like erythrocyte sedimentation rate.

8. removing when urticarial vasculitis shows effect has tangible hypocomplementemia, CIC ELISA and low-molecular-weight Clq precipitin occur in the obviously reduction of subunit Cla of change of serum C l, C4, C2 and the reduction of Cg moderate to severe, the serum.The visible skin heart wall of direct immunofluorescence inspection has immunoglobulin and complement deposit.

9. Autoimmune Chronic Urticaria can detect autoantibody; Adopt the autoserum tuerculoderma: the sterile test tube 30min that condenses is put in conventional blood drawing, and is centrifugal, gets serum 100 μ l to patient's row intradermal test; With the normal saline is contrast, and it is promptly positive greater than 9mm the welt diameter to occur like part behind the 1h.Other all can be selected for use like histamine release test, immunoblotting and elisa etc.

Two. case selection

All can be used as case for the patient who meets above-mentioned disease and observe, especially weak and sickly, middle-aged and elderly people, women, child are observed as first-selected case especially; The method of observing is then carried out complete observation through the method for hoping, asking, hearing, cutting to the patient; And for of all ages, the sex of the heavier patient of the state of an illness, without exception as the direct study subject of observing treatment.

Three. administrated method

According to acute urticaria patient's severe extent, the length of sick time, adopt Chinese patent medicine of the present invention for oral administration to treat, its method of administration is: three times on the one, each 6-12 gram, warm water delivery service; Ante cibum, one after each meal all can.Just the clothes phase is 30 days, and dose can increase doubly, after this takes medicine continuously by conventional dose, and three months is to observe with curative effect a course of treatment to judge.Chinese patent medicine of the present invention has no side effect through clinical application toxicity test proof because of Chinese medicine preparation, reasonable recipe, and therefore, but the patient takes Chinese patent medicine of the present invention the long period during treating, and need not dieting aspect the period in a medicine diet.Must pay special attention to during the medication treatment:

1. will be fully take medicine, cannot just not eat, itch and taken up and continued to eat, so not only can't effect a radical cure and also can drag into chronic urticaria because of not itching according to prescription and dosage;

2. take medicine continuously after a period of time, downgrade dosage according to patient's situation, and get final product drug withdrawal until being completely recovered;

3. in the acute stage medication minimum 1 month.In period in a medicine ten million drug withdrawal or downgrade medicament voluntarily, in order to avoid all that has been achieved is spoiled.

Four. curative effect determinate standard

1. recovery from illness: the rash piece disappears, the pruritus disappearance, and the above nothing outbreak of acute 1 week of person, chronic person did not have repeatedly more than half a year.

2. produce effects: the rash piece disappears, and pruritus disappears basically.Acute person still has a small amount of rash piece more than 1 week, slight pruritus is arranged; Chronic person's attack times reduces, and interval prolongs, and pruritus obviously alleviates, and still has petit mal after half a year.

3. effective: chronic person is through treatment, and the rash piece reduces, and attack times slightly reduces, and blanking time is slightly long, and the scabies ancient term for country school alleviates.

4. invalid: acute person in 1 week, chronic person endanthem piece on the 3rd and pruritus do not have improvement.

Five. the clinical treatment result

Chinese patent medicine of the present invention carries out orally taken for curing through all kinds of acute urticaria patients 196 examples that 2006-2010 is accepted for medical treatment in 4 years altogether, male's 69 examples wherein, and women's 127 examples, the age is 16-55 year; Its clinical treatment result according to above-mentioned domestic unified criterion of therapeutical effect statistical computation is: recovery from illness (drug withdrawal observe more than 3 years not recidivist) 99 examples, and cure rate is 50.51%; Produce effects (drug withdrawal observe more than 1 year not recidivist) 46 examples, obvious effective rate is 23.47%; Effective (symptom obviously alleviates the scurf major part and comes off, and still has the few part silver bits person of not moving back) 39 examples, effective percentage is 19.90%; Invalid (take medicine 2 courses of treatment not alleviator) 12 examples, inefficiency 6.12%; Total effective rate is 93.88%, and not seeing has any toxic and side effects.

Model case is introduced:

1 army, the man, 19 years old, live Shang Fang village, Yantai City Zhifu District south, on January 16th, 2008 went to a doctor in the applicant's out-patient department, and according to patient's readme ill existing half a year, skin presents erythema, itches especially, repeatedly goes to see a doctor, and does not all have positive effect and cures so far.Be the acute urticaria later stage after diagnosing, untimely because of treating, and change in chronic urticaria, take Chinese patent medicine of the present invention after course of treatment, the disease significant effective, after this continuous use is promptly fully recovered 5 courses of treatment.Treatment finishes the back not recurrence of visiting more than 2 years.

2, Guo Yanmei, the woman, 16 years old, live Yantai City's Zhifu District three roads, the student, on March 18th, 2009 went to a doctor in the applicant's out-patient department, had repeatedly gone to see a doctor since patient's readme is ill, and is bad during fashion, do not cure so far.Take Chinese patent medicine of the present invention after diagnosing after course of treatment, disease is not seen positive effect, but sensation effectively; Patient after this 3 course of treatment sides of continuous use sees obvious curative effects; Continuing to take Chinese patent medicine of the present invention promptly fully recovers 3 courses of treatment.After finishing, treatment visited not recurrence so far more than 1 year.

The specific embodiment

Embodiment 1

The described Chinese patent medicine of present embodiment is to press the row weight portion to take by weighing each Chinese crude drug: 3 parts in Herba Ephedrae, 3 parts of Rhizoma Zingiberiss, 5 parts in Herba Spirodelae, 5 parts in Semen Armeniacae Amarum, 10 parts of Cortex Dictamnis, 10 parts of Radix Salviae Miltiorrhizaes, 5 parts of Pericarpium Citri Reticulataes, 5 parts of Cortex Moutans, 5 parts of Bombyx Batryticatus, 5 parts of Herba Schizonepetae, windproof 5 parts, 10 parts of Flos Loniceraes, 5 parts of Fructus Arctiis, 5 parts in the Radix Rehmanniae, 5 parts of Radix Scutellariaes, 3 parts of Herba Menthaes, 3 parts of Periostracum Cicadaes, 5 parts of Radix Angelicae Sinensis, 5 parts of Radix Paeoniae Rubra, 5 parts of Folium Isatidiss, 3 parts of Radix Glycyrrhizae.

The described Chinese patent medicine of present embodiment is that its preparation technology is: above-mentioned each medicinal raw material is processed sublimed preparation according to the pharmaceutical methods that routine prepares sublimed preparation as the endo-medicine that is used to treat acute urticaria.

Embodiment 2

Press the row weight portion and take by weighing each medical material: 10 parts in Herba Ephedrae, 10 parts of Rhizoma Zingiberiss, 20 parts in Herba Spirodelae, 20 parts in Semen Armeniacae Amarum, 30 parts of Cortex Dictamnis, 30 parts of Radix Salviae Miltiorrhizaes, 25 parts of Pericarpium Citri Reticulataes, 25 parts of Cortex Moutans, 20 parts of Bombyx Batryticatus, 20 parts of Herba Schizonepetae, windproof 20 parts, 30 parts of Flos Loniceraes, 20 parts of Fructus Arctiis, 20 parts in the Radix Rehmanniae, 20 parts of Radix Scutellariaes, 10 parts of Herba Menthaes, 10 parts of Periostracum Cicadaes, 20 parts of Radix Angelicae Sinensis, 20 parts of Radix Paeoniae Rubra, 20 parts of Folium Isatidiss, 10 parts of Radix Glycyrrhizae.

The described Chinese patent medicine of present embodiment is that its preparation technology is: above-mentioned each medicinal raw material is processed packed powder according to the pharmaceutical methods that routine prepares powder as the endo-medicine that is used to treat acute urticaria.

Embodiment 3

Press the row weight portion and take by weighing each medical material: 5 parts in Herba Ephedrae, 5 parts of Rhizoma Zingiberiss, 10 parts in Herba Spirodelae, 10 parts in Semen Armeniacae Amarum, 15 parts of Cortex Dictamnis, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Cortex Moutans, 10 parts of Bombyx Batryticatus, 10 parts of Herba Schizonepetae, windproof 10 parts, 15 parts of Flos Loniceraes, 10 parts of Fructus Arctiis, 10 parts in the Radix Rehmanniae, 10 parts of Radix Scutellariaes, 5 parts of Herba Menthaes, 5 parts of Periostracum Cicadaes, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Paeoniae Rubra, 10 parts of Folium Isatidiss, 5 parts of Radix Glycyrrhizae.

The described Chinese patent medicine of present embodiment is that its preparation technology is: above-mentioned each medicinal raw material is processed unguentum according to the pharmaceutical methods that routine prepares unguentum as the endo-medicine that is used to treat acute urticaria.

Embodiment 4

Press the row weight portion and take by weighing each medical material: 8 parts in Herba Ephedrae, 8 parts of Rhizoma Zingiberiss, 15 parts in Herba Spirodelae, 15 parts in Semen Armeniacae Amarum, 25 parts of Cortex Dictamnis, 25 parts of Radix Salviae Miltiorrhizaes, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Cortex Moutans, 15 parts of Bombyx Batryticatus, 15 parts of Herba Schizonepetae, windproof 15 parts, 25 parts of Flos Loniceraes, 15 parts of Fructus Arctiis, 15 parts in the Radix Rehmanniae, 15 parts of Radix Scutellariaes, 8 parts of Herba Menthaes, 8 parts of Periostracum Cicadaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Paeoniae Rubra, 15 parts of Folium Isatidiss, 8 parts of Radix Glycyrrhizae.

The described Chinese patent medicine of present embodiment is as the endo-medicine that is used to treat acute urticaria; Its preparation technology is: above-mentioned each medicinal raw material is processed tablet according to the pharmaceutical methods that routine prepares tablet; (like conventional tablet, sugar coated tablet, film coated tablet etc.), and give conventional drug excipient (like starch, sucrose, lactose, calcium stearate, magnesium stearate etc.).

Embodiment 5

Press the row weight portion and take by weighing each medical material: 6.5 parts in Herba Ephedrae, 6.5 parts of Rhizoma Zingiberiss, 12 parts in Herba Spirodelae, 12 parts in Semen Armeniacae Amarum, 20 parts of Cortex Dictamnis, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Cortex Moutans, 12 parts of Bombyx Batryticatus, 12 parts of Herba Schizonepetae, windproof 12 parts, 20 parts of Flos Loniceraes, 12 parts of Fructus Arctiis, 12 parts in the Radix Rehmanniae, 12 parts of Radix Scutellariaes, 6.5 parts of Herba Menthaes, 6.5 parts of Periostracum Cicadaes, 12 parts of Radix Angelicae Sinensis, 12 parts of Radix Paeoniae Rubra, 12 parts of Folium Isatidiss, 6.5 parts of Radix Glycyrrhizae.

The described Chinese patent medicine of present embodiment is that its preparation technology is as the endo-medicine that is used to treat acute urticaria: above-mentioned each medicinal raw material is processed pill according to the pharmaceutical methods that routine prepares pill, and give conventional drug excipient.

Embodiment 6

Press the row weight portion and take by weighing each medical material: 5 parts in Herba Ephedrae, 5 parts of Rhizoma Zingiberiss, 12 parts in Herba Spirodelae, 12 parts in Semen Armeniacae Amarum, 30 parts of Cortex Dictamnis, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Cortex Moutans, 12 parts of Bombyx Batryticatus, 12 parts of Herba Schizonepetae, windproof 12 parts, 30 parts of Flos Loniceraes, 12 parts of Fructus Arctiis, 12 parts in the Radix Rehmanniae, 12 parts of Radix Scutellariaes, 5 parts of Herba Menthaes, 5 parts of Periostracum Cicadaes, 12 parts of Radix Angelicae Sinensis, 12 parts of Radix Paeoniae Rubra, 12 parts of Folium Isatidiss, 5 parts of Radix Glycyrrhizae.

The described Chinese patent medicine of present embodiment is that its preparation technology is: above-mentioned each medicinal raw material is processed oral liquid formulations according to the pharmaceutical methods that routine prepares oral liquid formulations as the endo-medicine that is used to treat acute urticaria.

Claims (6)

1. a Chinese patent medicine of treating acute urticaria is characterized in that being prepared from following medicaments in part by weight: Herba Ephedrae 3-10 part, Rhizoma Zingiberis 3-10 part, Herba Spirodelae 5-20 part, Semen Armeniacae Amarum 5-20 part, Cortex Dictamni 10-30 part, Radix Salviae Miltiorrhizae 10-30 part, Pericarpium Citri Reticulatae 5-25 part, Cortex Moutan 5-25 part, Bombyx Batryticatus 5-20 part, Herba Schizonepetae 5-20 part, windproof 5-20 part, Flos Lonicerae 10-30 part, Fructus Arctii 5-20 part, Radix Rehmanniae 5-20 part, Radix Scutellariae 5-20 part, Herba Menthae 3-10 part, Periostracum Cicadae 3-10 part, Radix Angelicae Sinensis 5-20 part, Radix Paeoniae Rubra 5-20 part, Folium Isatidis 5-20 part, Radix Glycyrrhizae 3-10 part.

2. the Chinese patent medicine of treatment acute urticaria according to claim 1 is characterized in that being prepared from following medicaments in part by weight: Herba Ephedrae 5-8 part, Rhizoma Zingiberis 5-8 part, Herba Spirodelae 10-15 part, Semen Armeniacae Amarum 10-15 part, Cortex Dictamni 15-25 part, Radix Salviae Miltiorrhizae 15-25 part, Pericarpium Citri Reticulatae 10-20 part, Cortex Moutan 10-20 part, Bombyx Batryticatus 10-15 part, Herba Schizonepetae 10-15 part, windproof 10-15 part, Flos Lonicerae 15-25 part, Fructus Arctii 10-15 part, Radix Rehmanniae 10-15 part, Radix Scutellariae 10-15 part, Herba Menthae 5-8 part, Periostracum Cicadae 5-8 part, Radix Angelicae Sinensis 10-15 part, Radix Paeoniae Rubra 10-15 part, Folium Isatidis 10-15 part, Radix Glycyrrhizae 5-8 part.

3. the Chinese patent medicine of treatment acute urticaria according to claim 1 is characterized in that being prepared from following medicaments in part by weight: 6.5 parts in Herba Ephedrae, 6.5 parts of Rhizoma Zingiberiss, 12 parts in Herba Spirodelae, 12 parts in Semen Armeniacae Amarum, 20 parts of Cortex Dictamnis, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Cortex Moutans, 12 parts of Bombyx Batryticatus, 12 parts of Herba Schizonepetae, windproof 12 parts, 20 parts of Flos Loniceraes, 12 parts of Fructus Arctiis, 12 parts in the Radix Rehmanniae, 12 parts of Radix Scutellariaes, 6.5 parts of Herba Menthaes, 6.5 parts of Periostracum Cicadaes, 12 parts of Radix Angelicae Sinensis, 12 parts of Radix Paeoniae Rubra, 12 parts of Folium Isatidiss, 6.5 parts of Radix Glycyrrhizae.

4. according to the Chinese patent medicine of the described treatment acute urticaria of the arbitrary claim of claim 1 to 3, it is characterized in that described Chinese patent medicine processes the oral medicine dosage form of pill, sublimed preparation, powder, tablet, unguentum, decoction and capsule dress powder according to the conventional technology of preparing of Chinese medicine.

5. the Chinese patent medicine of treatment acute urticaria according to claim 4 is characterized in that described Chinese patent medicine also contains drug excipient.

6. the Chinese patent medicine of the described treatment acute urticaria of the arbitrary claim of claim 1-3 is characterized in that described Chinese patent medicine is used for the application as the dermopathic Chinese patent medicine for oral administration of treatment acute urticaria.