CN103520552A - Traditional Chinese medicine composition for treating acute conjunctivitis and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating acute conjunctivitis. The traditional Chinese medicine composition is prepared from the following active pharmaceutical ingredients: honeysuckle, weeping forsythia, folium mori, radix isatidis, spica prunellae, radix sileris, herba schizonepetae, cyrtomium rhizome, great burdock achene, rhizoma phragmitis, dandelions, radix scutellariae, notopterygium root, Szechwan lovage rhizome, Chinese angelica, radix rehmanniae, Chinese gentian root, radix paeoniae rubra, wild chrysanthemum flower, periostracum cicadae, root-bark of densefruit pittany, liquorice, belvedere fruit, flos buddlejae, feather cockscomb seed, halite, white oak, pteris semipinnata, calamine and abrus herb. The composition mainly has the treatment effects of dispelling wind-evil and clearing away heat and toxic materials, mainly has the effects of clearing away heat and toxic materials and removing liver-fire for improving eyesight and removing nebula on patients in more severe conditions and patients with cornea affected, has simple preparation processes and small toxic and side effects, is convenient to administrate, is easy to prepare, is low in cost, can directly treat focuses, ensures short cure time and avoids relapse after cure.

Description

A kind of Chinese medicine composition for the treatment of acute conjunctivitis and preparation method thereof

 

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine composition for the treatment of acute conjunctivitis and preparation method thereof.

 

Background technology

Epidemic hemorrhagic conjunctivitis is a kind of outbreak of epidemic, violent acute conjunctivitis, is commonly called as " blood-shot eye illness ", is multiplely born in summer and autumn, and its pathogenic pathogen is Inhibition Tests with Enterovirus Type 70.Severe irritation and the watery secretion such as have violent pain, photophobia, shed tears; Eyelid is red and swollen, and conjunctiva height is congested, edema, point, lamellar or extensively hemorrhage under bulbar conjunctiva; Cornea fills the air point-like exuviation, and fluorescein is painted, before ear or submandibular lymph nodes enlargement.Primary disease feature is that morbidity is anxious, infectiousness is strong, irritation weight, and conjunctiva height is congested, edema, lymph gland enlargement before merging subconjunctival hemorrhage, corneal injury gill.

The acute conjunctivitis traditional Chinese medical science claims again acute and chronic conjunctivitis name of disease.Mean and break out eyelid and hyperemia of the bulbar conjunctiva edema, sufferings are handed over and are done, eye secretion and tears thickness, the disease of the raw nebula of black eyeball.See " silver-colored Nereid is micro-".Have another name called acute contagious conjunctivitis disease, acute contagious conjunctivitis, the violent rising sun of Zhu Yan.Be commonly called as again pink eye disease.Primary disease is how evil by wind heat poison, time row epidemic miasma due to, pink-eye quite up to the present.Easily cause and be widely current.Therefore, primary disease head is heavily prevented.Must disinfection and isolation to the used article of patient.The suitable heat clearing away for the treatment of by oral administration of medicines is loose evil, removing pathogenic heat from blood and toxic substance from the body.The name of disease of acute and chronic conjunctivitis is numerous.Yuan Dynasty's Effective Formulas Tested by Physicians for Generations claims " acute contagious conjunctivitis ", Ming Dynasty's " Precious Book of Ophthalmology " claims " acute contagious conjunctivitis ", and " silver-colored Nereid is micro-" describes rather detailed to this sick cause of disease, infectiousness and prognosis, think that acute and chronic conjunctivitis one people is ill, passing in one, is that the gas phase that belongs to toxic miasma is dyed for disease.One Zhou Keyu, if the course of disease is with the passing of time, the raw nebula of the eyeball that often can and turn black.Acute and chronic conjunctivitis is many by wind heat poison heresy, invaded excessive due to the order; Or because of lung stomach accumulated heat, inside and outside combined pathogens, above attacks in order and falls ill.From the beginning of ophthalmic, itch puckery, gradually trouble eye is husky puckery, and causalgia keeps in dark place, eyelid is wanted not open, and lacrimation is as soup, gum viscose eyelash, white of the eye blood vessel cloth around, severe patient white of the eye and born of the same parents' eyelid inner face have point-like or lamellar hemorrhage, and born of the same parents' eyelid is red and swollen, node pain before ear, or double being afraid of cold, heating, nasal obstruction watery nasal discharge, the uncomfortable General Symptoms that waits in the whole body.Ophthalmology ancient books such as " silver-colored Nereid is micro-" " order are through great achievement " also quite has discussion to eye itching disease, and " the micro-unbearable itching of silver-colored Nereid " thought: " unbearable itching person, Liver Channel is heated, and gallbladder is because of deficiency-heat, and ailment said due to cold or exposure is attacked and is filled all genus void of itching, and void is itched." order is through great achievement eye itching " thought: how origin itch is really, for fire is that wind is anemia.In a word, the traditional Chinese medical science is thought its etiology and pathogenesis not exogenous wind, heat, wet, empty, and lung meridian is subject to heresy, and liver and gall wind heat causes wind heat and violates order; Weakness of the spleen and stomach, damp is stagnated, strongly fragrant and heat-transformation, damp and hot accumulate stagnant fine in vain; Deficiency of liver-blood, wind syndrome due to blood-deficiency, wind syndrome caused by deficiency is violated order.Clinical diagnosis: pink eye disease morbidity is anxious, generally starts morbidity in bacterial infection 1-2 days, and majority is eyes morbidities.Infectiousness is strong, and primary disease is because immunity after curing is low, therefore can repeated infection (also can fall ill as contacted again patient), from baby to eight old man of 90 years old of some months, all may fall ill.Popular fast, suffer from after pink eye disease, be usually that a people falls ill, at 1-2, in week, cause the wide-scale distribution such as the whole family, kindergarten, school, factory, old children irrespective of sex, large quantities of patient infection.Mostly pink eye disease is the first sequela of eyes, ill early stage, and patient feels that eyes are hot, burns, photophobia, furious, conscious eyes mill pain, as entering as sand ground roll pain unbearably, and then eyelid is red and swollen, eye secretion is many, keep in dark place, shed tears, morning WA, the normal secreted thing of eyelid clings, and is difficult for opening.On some patient's conjunctivas, there is little petechia or ecchymosis, secretions is mucus purulence, sometimes on palpebral conjunctiva surface, form one deck canescence pseudomembrane, edge of cornea can have canescence to infiltrate point, and serious can be with General Symptomies such as headache, heating, fatigue, preauricular lymph nodes enlargements.

Modern medicine is thought, common pathogenic bacterium are Diplococcus pneumoniae kochweeks bacillus, hemophilus influenzae, staphylococcus aureus and streptococcus also can be seen, latter two antibacterial can parasitize in conjunctival sac usually, do not cause conjunctivitis, but sometimes can cause the outbreak of acute conjunctivitis yet when other conjunctive disorders and part or the reduction of whole body resistance.Antibacterial can directly contact conjunctiva by various kinds of media, in public places, collective unit is as rapid spread in kindergarten, school and family, causes popular.Particularly, in two seasons of spring and autumn, various respiratory tract diseases are as prevailing in influenza, rhinitis, and conjunctivitis is likely propagated through respiratory secretions by pathogenic bacterium.

After obtaining pink eye disease in treatment, wanted active treatment, General Requirements wants in time, thoroughly, adhere to.Once discovery, treatment immediately, interrupts, from the beginning of time, eyelid and conjunctiva swelling, available cold compress, every day 3 times, each 20 minutes.When blood-shot eye illness is suffered from a glance, another two should prevent that strong eye is also infected while not yet infecting, and when rinsing or putting drops in one's eyes, head should be partial to Ipsilateral, and head also should be partial to Ipsilateral in bed, in case secretions flows into strong eye.Symptom is still wanted continual cure 1 time-of-week after disappearing completely, in case recurrence.Treat flushable eyes, when trouble discharge of eye is more, should use suitable irrigation as normal saline or 2% boric acid water flushing conjunctival sac, every day 2-3 time, and clean margo palpebrae with disinfecting cotton swab.Also can be to suffering from eyespot collyrium or being coated with spongaion.As be bacterial infection, can select the most effective antibiotic eye dropping of eye drops according to the strain checking out, according to state of an illness weight, every 2-3 hour or per hour putting drops in one's eyes 1 time, conventional collyrium has 10%-20% sulphacetamide, 0.3% norfloxacin, 0.25% chloromycetin eyedrops etc., can be coated with Antibiotic Eye Ointment, as ciprofloxacin, chlortetracycline or tetracycline spongaion before sleeping evening, before each some medicine, need secretions scrub, to improve curative effect.The conjunctivitis that hybrid virus is infected, except the above Drug therapy of application, available antiviral collyrium also, as can be with 0.1% hydrobenzole collyrium, 0.1% peptide butylamine Emulsion for adenovirus, as can be with 0.1% iodouracil desoxyriboside, 0.1% acyclovir eyedrop etc. for small virus, every day 2-3 time, if desired also can application of interference element etc.While having ready conditions, can carry out antibacterial culturing, and do drug sensitive test, to select suitable antibiotic.

 

Summary of the invention

Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, new drug with low cost.The present invention is Chinese medicine composition, but the gentle Chinese medicine of selected abnormal smells from the patient.The present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, and safety, and toxic and side effects is little, and preparation is simple, the focus of going directly, and healing time is short, after curing, is difficult for recurrence.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of acute conjunctivitis, in described Chinese medicine composition, the ratio of weight and number of various crude drug is: 10～25 parts of Flos Loniceraes, 10～25 parts of Fructus Forsythiaes, 10～25 parts, Folium Mori, 10～25 parts of Radix Isatidis, 10～25 parts of Spica Prunellaes, 10～25 parts of Radix Saposhnikoviaes, 10～20 parts of Herba Schizonepetae, 10～20 parts of Rhizoma Osmundae, 10～20 parts of Fructus Arctiis, 10～20 parts of Rhizoma Phragmitiss, 10～25 parts of Herba Taraxacis, 10～20 parts of Radix Scutellariaes, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～25 parts of Rhizoma Chuanxiongs, 10～25 parts of Radix Angelicae Sinensis, 10～25 parts, the Radix Rehmanniae, 10～25 parts of Radix Gentianaes, 10～25 parts of Radix Paeoniae Rubra, 10～25 parts of Flos Chrysanthemi Indicis, 10～25 parts of Periostracum Cicadaes, 10～20 parts of Cortex Dictamni, 10～20 parts, Radix Glycyrrhizae, 10～20 parts of the Fructus Kochiae, 10～25 parts of Flos Buddlejaes, 10～20 parts of Semen Celosiae, 10～25 parts of halites, 10～20 parts of white oaks, 10～20 parts of Herba Pteridis Semipinnataes, 10～20 parts of 10～25 parts of Calaminas and Herba Abris.

The Chinese medicine composition of described treatment acute conjunctivitis, the ratio of weight and number of various crude drug can also be: 10～15 parts of Flos Loniceraes, 20～25 parts of Fructus Forsythiaes, 10～25 parts, Folium Mori, 15～25 parts of Radix Isatidis, 20～25 parts of Spica Prunellaes, 10～20 parts of Radix Saposhnikoviaes, 10～15 parts of Herba Schizonepetae, 10～20 parts of Rhizoma Osmundae, 10～20 parts of Fructus Arctiis, 10～20 parts of Rhizoma Phragmitiss, 10～15 parts of Herba Taraxacis, 10～15 parts of Radix Scutellariaes, 15～20 parts of Rhizoma Et Radix Notopterygiis, 20～25 parts of Rhizoma Chuanxiongs, 20～25 parts of Radix Angelicae Sinensis, 10～15 parts, the Radix Rehmanniae, 10～25 parts of Radix Gentianaes, 10～25 parts of Radix Paeoniae Rubra, 10～20 parts of Flos Chrysanthemi Indicis, 10～15 parts of Periostracum Cicadaes, 10～15 parts of Cortex Dictamni, 15～20 parts, Radix Glycyrrhizae, 10～15 parts of the Fructus Kochiae, 20～25 parts of Flos Buddlejaes, 10～15 parts of Semen Celosiae, 10～20 parts of halites, 10～15 parts of white oaks, 15～20 parts of Herba Pteridis Semipinnataes, 15～20 parts of 10～25 parts of Calaminas and Herba Abris.

The Chinese medicine composition of described treatment acute conjunctivitis, the ratio of weight and number of various crude drug can be also: 10～25 parts of Flos Loniceraes, 10～20 parts of Fructus Forsythiaes, 10～20 parts, Folium Mori, 10～20 parts of Radix Isatidis, 10～20 parts of Spica Prunellaes, 10～25 parts of Radix Saposhnikoviaes, 10～20 parts of Herba Schizonepetae, 15～20 parts of Rhizoma Osmundae, 10～15 parts of Fructus Arctiis, 15～20 parts of Rhizoma Phragmitiss, 10～20 parts of Herba Taraxacis, 10～20 parts of Radix Scutellariaes, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～25 parts of Rhizoma Chuanxiongs, 10～25 parts of Radix Angelicae Sinensis, 10～25 parts, the Radix Rehmanniae, 10～20 parts of Radix Gentianaes, 10～20 parts of Radix Paeoniae Rubra, 10～25 parts of Flos Chrysanthemi Indicis, 10～25 parts of Periostracum Cicadaes, 10～20 parts of Cortex Dictamni, 10～20 parts, Radix Glycyrrhizae, 10～20 parts of the Fructus Kochiae, 10～25 parts of Flos Buddlejaes, 10～20 parts of Semen Celosiae, 10～25 parts of halites, 10～20 parts of white oaks, 10～20 parts of Herba Pteridis Semipinnataes, 10～20 parts of 10～20 parts of Calaminas and Herba Abris.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of acute conjunctivitis, and the dosage form of described Chinese medicine composition is tablet, and described preparation method comprises:

A, by Flos Lonicerae, Fructus Forsythiae and Folium Mori are put into the ethanol heating and refluxing extraction of 60%-90%, obtain extracting solution 1;

B, get all the other surplus stocks again, add water heating and refluxing extraction, obtain extracting solution 2;

C, extracting solution 1 and extracting solution 2 merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain raw material medicinal liquid; Add dextrin or starch tabletting.

In described step a, by Flos Lonicerae, Fructus Forsythiae and Folium Mori are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour;

In described step b, raw material described in all the other is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 30 minutes～1 hour.

In described step c, extracting solution 1 and extracting solution 2 merged, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicinal liquid; Add starch or dextrin tabletting.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of acute conjunctivitis, and the dosage form of described Chinese medicine composition is eye drop, and described preparation process is:

A, get described crude drug and add water extraction 2 times, by extracting solution thickening filtration, obtain extractum 1, medicinal residues are standby;

B, the medicinal residues of described step a are added to 60-90% soak with ethanol 1 hour, extract twice, each 2 hours, merge extractive liquid,, 80-160 order filters, and 6000-10000 rev/min centrifugal, gets supernatant, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000,1.35 extractum 2 when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃;

C, extractum 1 and extractum 2 is mixed, add 0.05% sodium chloride and the 80-100 distilled water doubly that mix extractum gross mass, and to add concentration be that to regulate PH be 6.5-7.5 to 5% sodium hydroxide solution, add again 0.2% active carbon to boil 10 minutes, filter packing, sterilizing, obtains eye drop.

For solving the problems of the technologies described above, the present invention provides a kind of dosage form for the treatment of the Chinese medicine composition of acute conjunctivitis again, and described dosage form is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder or patch.

Described Chinese medicine composition, medicine is decocted in use decoction and is taken, and 1 dose of every day, decocting takes at twice, and every 7 days is a course for the treatment of; When this Chinese medicine composition is pill, capsule or tablet while using, three times on the one, every 7 days is a course for the treatment of.

Chinese medicine composition of the present invention has in treatment mainly loose evil to dispel the wind, and heat-clearing and toxic substances removing is main.Heavier and the person of involving wind wheel of the state of an illness, with heat-clearing and toxic substances removing, liver heat removing and eyesight improving nebula removing is main; And processing technology is easy, the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost.The present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, and safety, and toxic and side effects is little, and preparation is simple, the focus of going directly, and healing time is short, after curing, is difficult for recurrence.

 

The specific embodiment

Viral conjunctivitis belongs to the traditional Chinese medical science " acute and chronic conjunctivitis " and " epidemic keratoconjunctivitis " category.Traditional Chinese Medicine think primary disease be on sudden sense epidemic miasma, wind-heat evil toxin, attack due to."Nei Jing" is pointed out: " it is skin person, inducing diaphoresis ".Treatise on Febrile Diseases is pointed out: " floating pulse person, the disease being located in the exterior, can diaphoresis, Ephedrae Decoction ".The card that has disclosed wind heat can adopt the method for dispersing to treat.As " guide of silver sea " institute cloud " pathogenic heat of fire is feared it and is fallen into volt, therefore should send out it "." danxi's experiential therapy " pointed out: " wind-fire Sheng person, can not use the medicine of a cold nature suddenly, and the temperature of must holding concurrently is loose "." Jing Yue's complete work passes loyal record " thought: " fire of diseases caused by exogenous pathogenic factor is controlled wind in the ban, and wind is loose and fiery from breath "." the hexa-atomic large opinion of just recording of Plain Questions " pointed out: " dispersing fire for treating depression of fire ".Therefore viral conjunctivitis treatment is upper should be adopted and disperse the method that heat clearing away develops simultaneously and treat, in evacuating, have cold and cool, the unlikely fiery Sheng of pungent temperature; In pathogenic fire purging, have a surname to send out, pathogenic fire closes in unlikely.The traditional Chinese medical science thinks that primary disease is many because of diseases caused by exogenous pathogenic factor pestilential pathogen, or double lung stomach accumulated heat, and inside and outside combined pathogens is handed over to attack in order and sent out.Because violating on pestilential pathogen in order, white of the eye occupies outside order pearl layer, stand in the breach, therefore see hyperemia of the bulbar conjunctiva, husky puckery scorching hot, photophobia is shed tears, a lot of secretion in the eye is clear rare etc.Pestilential pathogen, property belongs to pyretic toxicity more, sees lung stomach accumulated heat as double, the visible excess syndrome of interior-heat such as the pain of eying covetously, headache dry pharynx, thirsty, dark coloured urine constipation, red tongue, yellow fur of suffering from.Morbidity severe one can be invaded and wind wheel, and the eyeball punctate keratitis that turns black.

Folium Mori, Fructus Arctii, Herba Schizonepetae, the loose heresy of Radix Saposhnikoviae dispelling wind in side, the heat-clearing and toxic substances removing such as Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Spica Prunellae, Rhizoma Osmundae, Rhizoma Phragmitis are to help heat clearing away.The state of an illness is compared with Herba Taraxaci, Radix Gentianae, Radix Scutellariae heat-clearing and toxic substances removing for severe one, the improving acuity of vision and removing nebula such as Flos Buddlejae, Semen Celosiae, Flos Chrysanthemi Indici, and purging liver-fire, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, playing altogether and dispeling the wind loose evilly, and the merit of heat-clearing and toxic substances removing, to reach eliminating evil object of curing the disease.Modern pharmacological research confirms, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Radix Isatidis, Herba Taraxaci, Flos Chrysanthemi Indici, Radix Saposhnikoviae etc. in side, and majority has the effects such as antiinflammatory, antibiotic, antiviral.So in the treatment of primary disease, on the basis with dialectical mutually unified, on purpose use these medicines to carry out prescription and make up a prescription, more strengthened the specific aim for the treatment of.Fructus Kochiae clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, notopterygium wind dispelling is antipruritic, and assistant is dispeled the wind with Periostracum Cicadae, and the meaning of " control wind and first control blood, blood wind from go out " is closed in Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Rehmanniae nourishing blood to expel wind.Modern pharmacological research shows, Periostracum Cicadae has the merit of antiinflammatory, antiallergic.The Calamina improving acuity of vision and removing nebula that can detoxify, removing dampness is antipruritic, and modern study shows that it has the function of refrigerant antipruritic, anti-inflammation detumescence, and can absorb wound surface acidic secretion thing, and putrefaction removing is carried pus and growing muscle.Halite clearing away heat and cooling blood, improving eyesight is moisturized, and Shennong's Herbal carries: " main improving eyesight, ophthalmalgia, QI invigorating, hard muscles and bones " Herba Abri heat clearing away.White oak, cures mainly infantile malnutrition, adult's hernia, acute conjunctivitis.Herba Pteridis Semipinnatae, heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Have in treatment mainly loose evilly to dispel the wind, heat-clearing and toxic substances removing is main.Heavier and the person of involving wind wheel of the state of an illness, with heat-clearing and toxic substances removing, liver heat removing and eyesight improving nebula removing.

Flos Lonicerae, the loose poison of heat clearing away, Compendium of Material Medica is carried " Flos Lonicerae, is good at removing toxic substances, therefore control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, analgesic, regulate the effect traditional Chinese medical science such as immunity to think, Flos Lonicerae is cold in nature, sweet in the mouth, gas are put down, and has the effect of heat-clearing and toxic substances removing, can treat the diseases such as pyretic toxicity abscess, carbuncle furuncle.And have the loose effect of a surname concurrently.Flos Lonicerae antipyretic and antidote functions is quite strong, is conventional product in surgery.

Fructus Forsythiae, hardship, is slightly cold.Return lung, the heart, gallbladder meridian.Fructus Forsythiae has broad-spectrum antibacterial action, and staphylococcus aureus, Hayes dysentery bacterium are had to very strong inhibitory action, and other pathogenic bacterium, influenza virus, fungus are had to certain inhibitory action.There is antiinflammatory action.The contained oleanolic acid of this product has heart tonifying, diuresis and hypotensive activity, and Citrin can reduce vascular permeability and fragility, prevents haemolysis.Decoct has the town effect of telling, anti-liver injury effect.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.Cure mainly carbuncle sore tumefacting virus, sucutaneous nodule scrofula, affection due to external wind and heat, epidemic febrile disease is from the beginning of, puckery pain of pyretic stranguria etc.1. " herbal classic ": main cold and heat, Mus flaccidity, scrofula, carbuncle malignant boil, goiter, stagnation of pathogenic heat.2. " not Lu ": remove tapeworm.3. " property of medicine opinion ": main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat.4. " Japan hanako materia medica ": logical small intestinal, evacuation of pus.Control furuncle, pain relieving, logical menstruation.5. Li Gao: loose all menses stagnation of QI are poly-; Detumescence.6. Wang Haogu: control deaf Hun Hun Jun Jun.

Folium Mori, dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight, cooling blood for hemostasis., cure mainly anemopyretic cold or pathogenic wind-warm from the beginning of, fever and headache, perspiration and aversion to wind, cough chest pain; Or dryness of the lung dry cough without phlegm; Dry throat and mouth; On wind heat and liver-yang, disturb; Conjunctival congestion and swelling pain.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.1. " herbal classic ": except cold and heat, perspire.2. Tang Materia Medica: decocting is got extract, except beriberi, edema, sharp intestine and small intestine.3. " Shandong Chinese medicine ": soothe sore throat, gingival swelling and pain, women's head-ornaments edema.4. supplement to the Herbal: main abdominal pain due to acute vomiting and diarrhea is told down, and take it with dense the boiling of dry person the eleventh month of the lunar calendar.Smooth file, takes as red sugar in large still, removes old wind and stagnated blood.5. " Japan hanako materia medica ": sharp the five internal organs, get round by bribery, the therapeutic method to keep the adverse QI flowing downwards, decoction; Except wind is perspired bitterly, and flutter damage blood stasis, and Zheng Hou An; Snakeworm Scolopendra stings, and salt Norway applies.6. " Bencao Tujing ": boil soup and drench let out brothers, go migratory arthralgia.7. " danxi's experiential therapy ": bake into powder, hollow rice is drunk the clothes that wither, only night sweat.

Radix Isatidis, heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.1. " Japan hanako materia medica ": control a day row pyretic toxicity.2. " book on Chinese herbal medicine is stated ": control a day row major part pyretic toxicity.3. " book on Chinese herbal medicine is just read ": Radix Isatidis is indigo-blue, its function nature and flavor and indigo-blue leaf with, can enter liver stomach blood system, but heat clearing away, detoxify, ward off epidemic disease, parasite killing.But leaf master is loose, and root master fall, this again with in different ear.4. " classification medical herbs ": separate all malicious malignant boil, loose poison reduces internal heat, and smashes juice or clothes or painting.5. " modern Practical Chinese medicinal ": rhizoma et radix baphicacanthis is refrigerant, analgesic, antidote, for erysipelas, lochiopyra etc.6. " Chinese medicinal herbal ": Qinghuo Jiedu, cooling blood for hemostasis.Control calentura and send out speckle, erysipelas, laryngopharynx swelling and pain, epidemic infection with swollen head, and the disease such as haematemesis, epistaxis.7. " Chinese herbal medicine handbook is commonly used in Liaoning ": treating the liver is scorching, parotitis.

Spica Prunellae, liver heat removing, eliminating stagnation, diuresis; Control the diseases such as pestilence, acute mastitis, ophthalmalgia, jaundice, gonorrhea, hypertension; Leaf can be for tea.Control that lymphoid tuberculosis, thyromegaly, scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia are shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leucorrhea with red and white discharge, metrorrhagia, puerperal blood faints, the motive wild, empty, the tinea versicolor white point of scrofula (no matter burst and do not burst, or with the passing of time becoming to leak), body.Attached side: the function of Spica Prunellae is liver heat removing and eyesight improving, has the effect of diuretic antihypertensive by stagnation resolvation tumor.

Radix Saposhnikoviae, effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly: affection of exogenous wind-cold; Headache general pain; Rheumatic arthralgia; Joint is ached; Stomachache is had loose bowels; Discharging fresh blood stool; Tetanus; Rubella pruritus; [3] skin infection is from the beginning of diseases such as, conjunctival congestion, pharyngalgia.Anti-wind, relieving exterior syndrome be take and dispeled the wind as length, can dispersing wind and cold, can disperse wind heat again, and similar with Herba Schizonepetae effect, therefore two medicines fit applications often.2, the pain relieving for rheumatic arthralgia wind energy wind-damp dispelling, often coordinates the diseases such as treatment rheumatic arthralgia such as Rhizoma Et Radix Notopterygii, Radix Stephaniae Tetrandrae.3, for tetanus, gnathospasma, opisthotonus.Radix Saposhnikoviae is controlled tetanus, has the effect of expellingging wind and relieving convulsion, but polygamy closes the medicines such as Rhizoma Arisaematis, Rhizoma Gastrodiae, Rhizoma Typhonii with using.In addition, this product has again hemostasis, anti-diarrhea effect, as having loose bowels for stomachache, often coordinates the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae to be equal to use; As for having blood in stool, metrorrhagia, general parch to black application.

Herba Schizonepetae, the loose wind that induces sweat, rash, the skin ulcer that disappears, hemostasis.For flu, measles is thoroughly sent out not smooth, has blood in stool, metrorrhagia, epistaxis.: dispel the wind; Induce sweat; Rash; Hemostasis.Main cold, fever; Headache; Eye itching; Cough; Laryngopharynx swelling and pain; Measles; Carbuncle; Skin ulcer scabies; Epistaxis; Spit blood; Have blood in stool; Metrorrhagia; Puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.1. " herbal classic ": main cold and heat, scrofula, the raw skin ulcer of scrofula, broken knot gather qi together, lower blood stasis, except arthralgia chiefly caused by damp pathogen.2. " property of medicine opinion ": control aversion to wind harmful wind, the askew heresy of actinal surface, insensitive impediment all over, has a guilty conscience and forgets things, and beneficial power is added grain.The main poison that exorcises evil spirits, except labor, controls fourth swollen; Get one and hold and cut, with five liters, water, boil and get two liters, cold minute two clothes, main promoting blood circulation, transmits the not enough gas of the five internal organs, can diaphoresis, except cold wind; Smashing again end and vinegar seals malicious swollen.3. the Meng numerous: postpartum apoplexy stiffness of the body is straight, grinds wine clothes into powder.

Fructus Arctii, dispelling wind and heat pathogens; Heat-clearing and toxic substances removing rash; Lung qi dispersing sore-throat relieving is loose swollen.Anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out not smooth and rubella pruritus; Sore swollen toxin and mumps etc.Raw with can loosening bowel to relieve constipation, pyretic toxicity red swelling and pain of throat, has constipation with heat retention concurrently especially suitable.For the not yet routed person of hot carbuncle toxin, normal and Herba Violae, the heat and toxic materials clearing away medicine compatibilities such as Flos Chrysanthemi Indici.

Rhizoma Phragmitis, returns lung meridian, stomach warp.Function: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.[3] Rhizoma Phragmitis is controlled cough due to lung-heat, lung abscess vomiting pus: Rhizoma Phragmitis enters the kind clear lung-heat thoroughly of lung meridian, and Rhizoma Phragmitis is controlled calentura excessive thirst: Rhizoma Phragmitis is sweet in flavor and cold in property, Rhizoma Phragmitis is controlled the puckery pain of pyretic stranguria: Rhizoma Phragmitis function clearing away heat and promoting diuresis, the available puckery pain of pyretic stranguria of controlling, oliguria with reddish urine, often joins the use such as Rhizoma Imperatae, Semen Plantaginis.

Herba Taraxaci, sweet, micro-hardship, cold.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Enter spleen, stomach, kidney three warps.Cure mainly: upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, cholecystitis, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.In Herba Taraxaci plant, contain the multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin, have the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci contains protein, fat, carbohydrate, trace element and vitamin etc. simultaneously, has abundant nutritive value.The carotene wherein containing and C and mineral, the effect that dyspepsia, constipation are all improved.Leaf is also improved eczema in addition, the effect of the dermatitis of releiving, and root has antiinflammation, and flower is decocted into medicine juice can remove freckle.

Radix Scutellariae, Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestinal profit and water from by, source is clearly flowed also clean.The blood person of closing, excess-heat is at blood system, and amenorrhea is made us obstructed in instant heating human blood chamber, damp and hot solution, Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is stayed knot, and is that carbuncle stain is also rotten: acute scleritis person, fire of moxibustion blood trouble also, removing heat from blood heat extraction, spontaneous recovery also.

Rhizoma Et Radix Notopterygii, loose exterior cold; Wind-damp dispelling; Profit joint; Pain relieving.Main affection of exogenous wind-cold; Have a headache lossless; Mimeograph cold-damp numbness; Edema due to wind pathogen edema; Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.The cold expelling that induces sweat, expelling wind and dampness, pain relieving.1, for affection of exogenous wind-cold, fever with aversion to cold, the cards such as headache general pain.This product has stronger dispersing wind-cold and analgesic effect.Normal and Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Herba Asari are equal to use, as Notoptreygium Decoction of Nine Ingredients.2, for arthrodynia of extremities, aching pain in should and back due to wind-cold damp pathogen invasion and attack, especially more applicable with upper part of the body pain.This product can be dispeled the wind and be won temperature, dispersing cold for relieving pain.Normal and Radix Saposhnikoviae, same use, as JUANBI TANG.1. " property of medicine opinion ": " control harmful wind, aphonia in silence, the blood leprosy of itching, hands and feet caused by paralysis, the askew heresy of actinal surface, insensitive impediment all over more." 2. " Japan hanako materia medica ": " controls a wind cutting gas, muscles and bones fist contraction, and extremity are thin bad, and head revolves the red pain of eyes and fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times aqueous vapor, five kinds of strain and seven kinds of impairment, deficient cold air, joint ache, tonneau the five internal organs.

Rhizoma Chuanxiong, blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Textual criticism: come from Materia Medica of Decoction and cure mainly: medicine first choice for the treatment of headache.Menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; Ulcer sores." herbal classic ": main apoplexy enters brain headache, arthralgia due to cold, clonic spasm of the muscle emergency, gold wound, married woman's blood closes loss of fecundity." not Lu ": except cold moving in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold.TAO Hong-Jing: tooth root bleeder, is recovered more than containing." property of medicine opinion ": control waist foot weak, hemiplegia, main afterbirth does not go out, and controls cold type of pain in abdomen." Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, and strengthening bone and muscle, adjusts many arteries and veins, and broken crux stagnated blood, supports fresh blood, puts on flesh, and serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, scrofula wart is superfluous, skin ulcer scabies, and evacuation of pus repercussive blood." medicine origin ": enrich blood, control headache due to deficiency of blood.Wang Haogu: search irritability, tonifying liver blood, profit liver is dry, mends wind empty." detailed outline ": dampness, antidiarrheal dysentery, activating QI to alleviate the depression.Rhizome of chuanxiong Qiong, in blood gas medicine also, liver bitter anxious with pungent benefit it, therefore blood deficiency person should it; Pungent to fall apart it, therefore stagnation of QI person should it." left biography " sayed wheat Qu, brought up poor imperial wetting, and controls stomach ailment.Give and control dairrhea caused by pathogenic damp, often add two tastes, it should be as sound.Dysentery is led to and the more than person of pain, is the cloudy stagnation of QI of losing, and in medicine, adding rhizome of chuanxiong is assistant, and gas promoting the circulation of blood is adjusted, and its disease stops immediately.Amplification on Canon of Materia Medica: rhizome of chuanxiong Qiong, moderns are used at most, women's head-ornaments wind can not fault also, so must help it with his medicine.

Radix Angelicae Sinensis, the dry root that these product are umbelliferae angelica.Autumn end excavates, and removes fibrous root and silt, after moisture slightly evaporates, is bundled into wisp, and upper canopy, with pyrotechnics smoke-dried beancurd slowly.Radix Angelicae Sinensis root is slightly cylindrical, and root upper end claims " returning head ", and main root claims " returning body " or " very little body ".Supporting root claims " Radix Angelicae Sinensis " or " returning lower limb ", all claim " Radix Angelicae Sinensis ".Radix Angelicae Sinensis can be enriched blood, can invigorate blood circulation again, and general designation and blood; Radix Angelicae Sinensis body is enriched blood, Radix Angelicae Sinensis removing blood stasis sweet in the mouth; Pungent; Bitter; Warm in nature.Return liver; The heart; Spleen channel.Hematonic; Emmenagogue; Analgesic.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.

The Radix Rehmanniae, heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; There is clearing away heat and cooling blood effect for the warm febrile disease blood of joining the army, high fever coma, xerostomia crimson tongue.As qingying decoction.Control the convalescent stage of febrile disease, waste heat not to the greatest extent, hinder by cloudy liquid, night fever abating at dawn, and red tongue rapid pulse person, as QINGHAOBIEJIATANG.Can be used for controlling the warm febrile disease blood of joining the army, heat in blood poison is contained, hematemesis and epistaxis, and macule purple is black.As Sisheng Wan; YIN nourishing and the production of body fluid promoting effect is thirsty for Tianjin wound, and interior-heat is quenched one's thirst.Control epidemic febrile disease impairment of YIN, dryness of the intestine constipation, as Zengye Tang.Bright Radix Rehmanniae sweet in the mouth bitterness Great Cold, acts on similarly to Radix Rehmanniae, and the power of YIN nourishing is slightly inferior, but clearing away heat and promoting production of body fluid, the power of cooling blood for hemostasis is stronger.

Radix Gentianae, eliminating pathogen in the liver arresting convulsion.Jaundice due to damp-heat; Urine leaching pain; Swelling of the vulva pudendal pruritus; Damp-heat vaginal discharge; The feeling of fullness in the head headache of liver and gall excess-fire; Conjunctival congestion and swelling pain; Deaf ear is swollen; Hypochondriac pain bitter taste; Calentura convulsion with spasms.Radix Gentianae eliminating pathogen in the liver gallbladder excess-fire, except damp-heat in lower-JIAO.Treating the liver is through intenseness of heat, and infantile convulsion is manic, encephalitis B, and headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.For damp and hot yellow cellulitis, swelling of the vulva pudendal pruritus, leukorrhagia, eczema pruritus, deafness, hypochondriac pain, bitter taste, convulsion with spasms.1. " herbal classic "; " continuous wound absolutely, determines the five internal organs, kills diseases due to noxious agents produced by various parasites for cold and heat between main bone, frightened lame pathogen." 2. " not Lu ": ", except latent heat in stomach, seasonal epidemic pathogens be warm, and diarrhea of heat type diarrhea goes small worm in intestinal, the liver benefiting courage, and spasmolytic is cautious." 3. " property of medicine opinion ": " main pediatric epilepsy scared enters the heart, high fever bone heat, carbuncle; While controlling, disease heat is yellow, aphtha." 4. " Japan hanako materia medica ": " controls infantile convulsive seizure due to fright, infantile malnutrition gas, and calentura delirium, skin ulcer scabies, improving eyesight, only tired." 5. " this sketch footpath ": " ancient prescription control subcutaneous ulcer multiplex it." 6. 《 Lv Cliff rock book on Chinese herbal medicine ": " controlled alcoholism and had blood in stool, discharging fresh blood stool." 7. " medicine origin ": " conjunctival congestion of harnessing the Yellow River is swollen, inflammatory exophthalmos, and stasis of blood meat is raised, unbearably painful." curing mainly secret formula " cloud: control the inferior portion's rheumatism and damp and hot, umbilicus swells and ache down to foot, the disturbance of lower legs due to pathogenic cold and dampness." 8. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controlled and had sore throat, and washes skin ulcer scabies poison swollen." 9. " Elementary Medicine ": " controls sudden onset of precordial pain, and worm is made a psychological attack bitterly, limbs pain." 10. " detailed outline ": " treats throat pain, wind heat night sweat.Weakness of the spleen and stomach is let out and is avoided clothes without damp and hot excess-fire person.1. Lei Gong's Treatise on Preparation and Broiling of Materia Medica: " not on an empty stomach bait it, make us excessive and can't help." 2. Collective Notes to the Canon of Materia medica: " Rhizoma Osmundae makes for it.Dislike Radix Rehmanniae, Radix Peucedani japonici." 3. " Japan hanako materia medica ": " Semen Phaseoli is for making."

Radix Paeoniae Rubra, clearing away heat and cooling blood; Blood circulation promoting and blood stasis dispelling.Main maculae caused by violent heat pathogen; Hematemesis and epistaxis; Discharging fresh blood stool; Conjunctival congestion and swelling pain; Carbuncle skin infection; Amenorrhea; Dysmenorrhea; Metrorrhagia and leukorrhagia stranguria with turbid discharge; The stagnant hypochondriac pain of the stasis of blood; Hernia abdominal mass is gathered; Injury from falling down.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.1, Shennong's Herbal: " Radix Paeoniae, bitter in the mouth is flat.Main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending cold and heat hernia abdominal mass, pain relieving ... raw Semen Coicis." 2, beam " Mingyi Bielu " says: " the raw Central Mountain Semen Coicis of Radix Paeoniae and hills, February, that adopt root August is suddenly and violently dry." 3, TAO Hong-Jing says: " the present goes out Bai Shan ,Jiang mountain, the Maoshan Mountain is best, and Bai Erchang chi is permitted.Remaining place also has and how red, red person's minor benefit." 4, Song Mazhi says: " this has red white two kinds, and its flower also has red white dichromatism." 5, Su Song says: " the present has it everywhere, Huaihe River product person victory.Spring, raw red bud was done clump, three five leaves on stem, and like Paeonia suffruticosa and long and narrow, high one or two chis.Early summer is bloomed, have red trillium several, knot is like Paeonia suffruticosa son and little.Qiu Shicaigen.Cui leopard is noted cloud at all times: Radix Paeoniae has two kinds: have Paeonia obovata Maxim., wooden Radix Paeoniae.Wood person spends greatly and color depth, and custom is exhaled as Paeonia suffruticosa, and non-Radix Paeoniae has golden Radix Paeoniae, the white speck of color; The purple thin many arteries and veins of wood Radix Paeoniae color.”

Rhizoma Osmundae, heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing.Cure mainly 1, anemopyretic cold, maculae caused by violent heat pathogen.This product bitter cold, the excess-heat can clearing heat in QI system dividing, has the pyretic toxicity that can separate blood system, card due to all warm malicious heresies all available it, be often equal to use with Rhizoma Coptidis, Folium Isatidis, Radix Glycyrrhizae, as Rhizoma Osmundae fall apart (" Prescriptions for Universal Relief ").Single product or join Folium Mori, Flos Lonicerae etc. and can prevent and treat anemopyretic cold; If with compatibilities such as Radix Isatidis, Folium Isatidis, Radix Arnebiae (Radix Lithospermi)s, can be used for again the diseases such as mumps, maculae caused by violent heat pathogen, dermexanthesis.2, heat in blood is hemorrhage.This product bitter in the mouth is slightly cold, and main enters Liver Channel, has the merit of cooling blood for hemostasis, cures mainly epistaxis due to heat in blood, spits blood, has blood in stool, the disease such as metrorrhagia, the outstanding kind metrostaxis of controlling.As " Bencao Tujing " controls epistaxis, can single grind into powder and be taken after mixing with liquid; If associate with Rhizoma Coptidis, grind Oryza glutinosa drink into powder and be taken after mixing with liquid, can control haematemesis, as Rhizoma Osmundae loose (" Shengji Zonglu "); Treating hematochezia can compatibility Cacumen Platycladi; Controlling metrostaxis can be with Oletum Trogopterori with using.3, worm disease.This product has the merit of parasite killing.For multiple Enterozoas such as killing and expelling tenia, ancylostome, pinworm, ascarids.Can use with anthelmintic compatibility.4, this product also can be used for treating burn and scald and injures married woman and be with inferior disease.

Flos Chrysanthemi Indici, function heat-clearing and toxic substances removing, detumescence.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all there is inhibitory action.Furuncle; Carbuncle; Erysipelas; Eczema; Dermatitis; Anemopyretic cold; Laryngopharynx swelling and pain; Hypertension.Song dynasty scape shines and says in " shepherd boy chats ": " true chrysanthemum prolongs age, and Herba Dendranthematis indici lets out people." property of Flos Chrysanthemi Indici bitter cold is better than Flos Chrysanthemi and Herba Tagetis Patulae, solely arrogates to oneself the merit of heat clearing away, is generally used for treatment furuncle carbuncle, have a headache dizzy, conjunctival congestion and swelling pain.The traditional Chinese medical science thinks that Flos Chrysanthemi Indici has the effect of heat-clearing and toxic substances removing, and modern clinic is widely used in treatment carbuncle sore tumefacting virus, eczema, cervicitis, prostatitis, anal sinusitis etc.1. " book on Chinese herbal medicine converges and says ": removing blood stasis is soothing the liver, separates the loose poison of furuncle.Stagnated blood in housewife people's abdomen, the red furuncle of the capable fire-toxin of Xie Tian.Wash skin ulcer scabies, can remove again wind parasite killing.2. " modern Practical Chinese medicinal ": for carbuncle, treat the swollen disease of suppurating.3. " Suzhou this product medical material ": removing toxic substances dispelling wind.Control order disease dizzy.4. " Zhejiang Chinese medicine handbook ": promoting pus discharge and removing toxic substances, reducing swelling and alleviating pain.Control carbuncle and treat poison, day bleb eczema.

Periostracum Cicadae, sweet, cold.Return lung, Liver Channel.Function cures mainly loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta, convulsion with spasms, tetanus.(1) for affection due to external wind and heat, fever with chills, cough, and the disease such as rubella, skin pruritus.Periostracum Cicadae has dispelling wind and heat pathogens effect, for wind heat table disease, often coordinates Herba Menthae to be equal to use; The function that rubella pruritus is also had to dispelling wind for relieving itching.(2) for measles, thoroughly send out not smooth.Periostracum Cicadae thoroughly sends out and has heat clearing away effect, because it is mainly dispelling wind heat, therefore in the majority from the beginning of thoroughly sending out impassable patient for measles, normal with Fructus Arctii, Herba Menthae with use; But as intenseness of heat rash goes out not freely, can join the application such as Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae again.(3) for diseases such as laryngopharynx swelling and pain and hoarseness.Laryngopharynx swelling and pain that Periostracum Cicadae is controlled is generally advisable with affection due to external wind and heat causer, because it has dispelling wind heat, throat effect, and many and Herba Menthae, Fructus Arctii, Fructus Forsythiae, Radix Platycodonis, Radix Glycyrrhizae fit applications.As for controlling hoarseness, with the strongly fragrant lung of ailment said due to cold or exposure, Lung Qi obstraction institute causer, be advisable, get the merit of its lung qi dispersing sound producing, often close Radix Platycodonis, Semen Oroxyli, Semen Sterculiae Lychnophorae and be equal to use.(4), pterygium swollen for conjunctival congestion.The conjunctival congestion that these product cause wind heat, cataracta, and the raw nebula film of order after measles, have improving acuity of vision and removing nebula effect, can join the application such as Flos Chrysanthemi, Flos Eriocauli, Fructus Atriplicis Sibiricae.(5) for diseases such as tetanus, infantile convulsion, night cry.The Periostracum Cicadae exogenous wind of can dispelling, can cease endogenous wind and the spasmolytic of calming the frightened again, and tic of the limbs is appearred in tetanus, can join Scorpio and be equal to use; Infantile convulsion, the nocturnal fretfulness in infants are occurred to infantile convulsion is uneasy, can join Ramulus Uncariae Cum Uncis and be equal to use.

Cortex Dictamni, Cortex Dictamni comes from " property of medicine opinion ", is loaded in Shennong's Herbal.Be mainly used to treat " wind syndrome of head, jaundice, reversible, drench drop.In woman's the moon, swell and ache, the dead flesh of arthralgia chiefly caused by damp pathogen, unable to flex and stretch the extremities start-stop row step.Gui Jing: spleen channel; Lung meridian; Small intestine meridian; Stomach warp; Urinary bladder channel.Function: heat clearing and damp drying; Dispelling wind for relieving itching; Removing toxic substances.Cure mainly: the rubella due to wind heat noxious dampness; Eczema; Scabies; Jaundice; Damp-heat arthralgia.

Radix Glycyrrhizae, treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw by pathogenic fire purging heat, the ripe use exterior cold of fall apart, goes pharyngalgia, except pathogenic heat, delays healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.Radix Glycyrrhizae is for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and deficiency of spleen-QI and stomach-QI, fatigue and weakness etc.The former, normal and Ramulus Cinnamomi compatibility, as Ramuli Cinnamomi and Glycyrrhizae Decoction, zhigancao decoction.The latter, normal is equal to use with Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, as decoction of four noble drugs, manage in ball etc.For asthma and cough.Can be alone, also can the application of compatibility other drug.As control the ERCHEN TANG of cough due to damp-phlegm; Control the Linggan Wuwei Jiangxin Tang of cold-phlegm cough with asthma; Control the sangxing decoction of dry stool phlegm cough; Control pyretic toxicity and cause the Radix Platycodonis decoction of the stench purulent sputum of lung abscess cough and spit; Control the Radix Glycyrrhizae Rhizoma Zingiberis soup of cough and spit saliva foam etc.The also Chang Peiwu application of another cough due to pathogenic wind-heat, cough due to wind and cold, phlegm heat cough.For ulcer sores, laryngopharynx swelling and pain etc.Ulcer sores, normal and Flos Lonicerae, Fructus Forsythiae are equal to use, play altogether the merit of heat-clearing and toxic substances removing, as Xian fang Huoming Yin.Laryngopharynx swelling and pain, the normal and same use of Radix Platycodonis, as Radix Platycodonis decoction.If pesticide, alimentary toxicosis, often join Semen phaseoli radiati or be decocted in water for oral dose with Radix Saposhnikoviae.For being in harmonious proportion the strong of some drugs.As seasoning CHENGQI TANG relaxes the discharge function of Radix Et Rhizoma Rhei, Natrii Sulfas by this product and gastrointestinal is stimulated.In addition, in many prescriptions, also commonly use this product coordinating the actions of various ingredients in a prescription.For stomachache, stomachache and gastrocnemius contraction urgency pain etc., the normal and same use of Radix Paeoniae, can significantly strengthen the curative effect of controlling the anxious pain of contraction, as peony and licorice decoction.

The Fructus Kochiae, cold in nature, acrid in the mouth, hardship.Function cures mainly clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.Diuresis, clearing away damp-heat.Control dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, pudendum pruritus due to damp pathogen.1. " herbal classic ": " main bladder heat, diuresis.Invigorating middle warmer, beneficial vital essence.Steam in " 2. " not Lu ": " peeling skin, loose malignant boil, hernia abdominal mass, reinforcing YIN-essence, makes people moist." 3. " property of medicine opinion ": ", with Actinolitum with clothes, main husband's impotence does not rise, QI invigorating benefit power; Control cloudy ovum Huang disease, the wind that reduces phlegm and internal heat, can make soup and take a shower.It is red swollen that " 4. " Japan hanako materia medica ": " controls exopathogenic heat." 5. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " sharp bladder urine accumulated heat, washes the wind of skin, treats married woman all through exopathogenic heat, clear sharp fetal heat in pregnancy, damp-heat vaginal discharge.Accumulated heat in " 6. " book on Chinese herbal medicine is original ": " peeling skin, except skin exogenous damp is itched." 7. essentials of Matea Medica: " beneficial smart reinforcing YIN-essence, except deficiency-heat, diuresis and treating stranguria." 8. " beautiful Chinese catalpa medicine solution ": " treated the head and swollen and ache, and inguinal hernia the moon is ruined, pain in the lumbar region hypochondriac pain, dysentery, malignant boil."　

Flos Buddlejae, heat clearing away nourishing the liver, improving acuity of vision and removing nebula.Cure mainly: for conjunctival congestion and swelling pain, many tear photophobia, the nebula of looking unfamiliar film, hepatasthenia dim eyesight, blurring of vision.Liver heat removing and eyesight improving: this product is ophthalmology medicine dedicated, for the oculopathy of blood deficiency liver-heat, often joins Fructus Lycii, Semen Cuscutae.Treating the liver is often joined Semen Celosiae, Flos Chrysanthemi etc. through the oculopathy of excess-heat.1. " Kaibao Bencao ": " main optic atrohic blindness skin nebula, red puckery many eye secretion and tears, blood vessel in the order that disappears, children's's bran bean and infantile malnutrition gas are attacked eye." 2. Liu Wansu: " controlling photophobia is afraid of day." 3. Wang Haogu: " profit liver is dry.”

Semen Celosiae, liver heat removing, improving eyesight, nebula removing.For liver-heat conjunctival congestion, the nebula of looking unfamiliar film, blurring of vision, dizziness due to liver-fire.1, liver heat removing and eyesight improving: be mainly used in flaming up of liver-fire, conjunctival congestion and swelling pain, the raw nebula film of order, poor vision.2, these product also can be used for liver-fire type hypertension.

Halite, purges heat; Removing heat from blood; Improving eyesight; Moisturize.Main hematuria; Spit blood; Radula is hemorrhage; Conjunctival congestion and swelling pain; The rotten string of wind-eye; Toothache; Constipation.1, Shennong's Herbal: " halitum.Main improving eyesight, ophthalmalgia ... " 2, beam " Mingyi Bielu " says: " halitum raw salt hill ，Ji Xi Qiang backlands, Fu Lu city, Jiuquan southeast corner recklessly.The Qing， South Sea, the North Sea is red.Adopt October." 3, TAO Hong-Jing says: " in history records speech captive, salt has nine kinds: white salt, Sal, eater; The main abdominal distention fullness caused by stagnant QI of black salt; The main deaf ophthalmalgia of Hu salt; Soft salt, main horse ridge skin ulcer; Have again red salt, refute salt, four kinds of smelly salt, Dens Equi salt, not food.Dens Equi crude salt, the black salt alkali that is suspected to be, soft salt is suspected to be halitum, and this halitum has another name called salt recklessly, two three-phases are disorderly.In modern halitum captive, very have, from Liangzhou, come, also from Dunhuang, come.Its shape is made piece sheet, or as chicken and duck ovum or as purple in Pedicellus et Pericarpium Trapae, color white, taste is very salty, mouthful tasting gas smelly is true as the smelly son of Infertile-egg Ovum Gallus domesticus.Again in the mud of salt pond, Henan, own solidifying salt is as flag, break all square, lividity, doubting this is again halitum.There is salt well on the east of Sichuan Qu Sai Xian Bei precipice again, saline self-solidifying, and raw umbrella alite, one or two cun of sides, central projection is opened as umbrella shape, and also the side of having is as Gypsum Fibrosum, rich chess person.”

White oak, another name chestnut tree, trillium Pu Shu.Fagaceae white oak Quercus fabri Hance, is used as medicine with the insect gall of fruit.Be distributed on the south the Changjiang river and each province, south China.Cure mainly infantile malnutrition, adult's hernia, acute conjunctivitis.

Herba Pteridis Semipinnatae, calls half of Herba pteridii latiusculi, monolithic saw, half of tooth, half of comb, Pe1lionia tsoongii (Merr.) Merr. medicine.For Pteridaceae Pteris plant Herba Pteridis Semipinnatae Pteris semipinnata L., with all herbal medicine.The four seasons can adopt, and clean using fresh herb or dry.Nature and flavor are bitter, pungent, cool.Cure mainly heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For bacillary dysentery, acute enteritis, icterohepatitis, conjunctivitis; Traumatic injury is controlled in external, traumatic hemorrhage, skin infection furuncle and phyma, eczema, venom.

Calamina, odorless, taste is micro-puckery.Function cures mainly: removing toxic substances improving acuity of vision and removing nebula, the antipruritic sore of removing dampness.For conjunctival congestion and swelling pain, marginal blepharitis, nebula film bulbar conjunctiva polyp, ulcer being unable to heal, pus is dripping, eczema, skin pruritus.Control order swollen side " Imperial drug institution side " cruelly; Control the wind-eye rotten string side " the simple and easy side of health " of shedding tears; Control dizzy dim-sighted side " the simple and easy side of health "; Control the inferior infantile malnutrition erosion of vulva side " secretly handing down through proved recipe "; Control polyhidrosis around the external genitals pruritus due to damp pathogen " Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House ".

Herba Abri, clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.Main icterohepatitis, stomachache, rheumatic ostalgia, traumatic injury stasis of blood pain, mastalgia, heat-clearing and toxic substances removing, Shugan Zhitong.Side of body rib does not relax, epigastric distending pain; Acute hepatitis, chronic hepatitis, mastitis.1.《 Nanning City medicine will ": eliminating inflammation and expelling toxin, control infectious hepatitis, traumatic injury is refuted bone.Leaf: smash floss and apply breast ulcer.2. " middle traditional Chinese medicines are planted illustrated handbook ": dispelling the wind and dampness pathogens osteodynia, traumatic injury blood stasis internal injury; And make refrigerant antipyretic.3. " south of the Five Ridges herbal ": hot and suffocating clearly, soothing liver-QI, and spleen, continuous injured.4. Guangzhou army " conventional Chinese herbal medicine handbook ": clearing away heat-damp and promoting diuresis, Shugan Zhitong.Treating acute and chronic hepatitis, cirrhotic ascites, stomachache, urine twinge, venom.

 

Embodiment 1 capsule

The preparation process of capsule of the present invention is: extracting honeysuckle 1500g, Fructus Forsythiae 1000g, Folium Mori 1200g, Radix Isatidis 1000g, Spica Prunellae 1800g, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collect volatile oil, medicinal liquid filters, and medicinal residues are standby, by medicinal residues and Radix Saposhnikoviae 1200g, Herba Schizonepetae 1500g, Rhizoma Osmundae 1400g, Fructus Arctii 1000g, Rhizoma Phragmitis 1200g, Herba Taraxaci 1000g, Radix Scutellariae 1800g, Rhizoma Et Radix Notopterygii 1200g, Rhizoma Chuanxiong 1000g, Radix Angelicae Sinensis 1200g, Radix Rehmanniae 1000g, Radix Gentianae 1600g, Radix Paeoniae Rubra 1000g, Flos Chrysanthemi Indici 1600g, Periostracum Cicadae 1500g, Cortex Dictamni 1000g, Radix Glycyrrhizae 1600g, Fructus Kochiae 1200g, Flos Buddlejae 1500g, Semen Celosiae 1000g, halite 1000g, white oak 1200g, Herba Pteridis Semipinnatae 1500g, Calamina 1700g and Herba Abri 1200g, add 60-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, adding for the first time 5-10 doubly measures, adding for the second time 5-10 doubly measures, merge extractive liquid, filter, with above-mentioned two filtered solutions, merge to filter, 1.10-1.50 when filtered solution is evaporated to relative density and is 80 ℃, precipitate with ethanol twice, adjusts concentration of alcohol 60-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 ℃, obtains extractum, get above-mentioned extractum, add volatile oil and vegetable oil appropriate, vegetable oil adds 3% of extractum and volatile oil gross mass, mixes, and with colloid mill, grinds 10 minutes, constantly stirs, and is chilled to room temperature, incapsulates in shell every 0.4g.

Embodiment 2 eye drop

The preparation process of eye drop of the present invention:

A, extracting honeysuckle 1200g, Fructus Forsythiae 1600g, Folium Mori 1200g, Radix Isatidis 1500g, Spica Prunellae 1000g, Radix Saposhnikoviae 1400g, Herba Schizonepetae 1200g, Rhizoma Osmundae 1700g, Fructus Arctii 1500g, Rhizoma Phragmitis 1300g, Herba Taraxaci 1500g, Radix Scutellariae 1000g, Rhizoma Et Radix Notopterygii 1200g, Rhizoma Chuanxiong 1300g, Radix Angelicae Sinensis 1500g, Radix Rehmanniae 1000g, Radix Gentianae 1800g, Radix Paeoniae Rubra 1200g, Flos Chrysanthemi Indici 1000g, Periostracum Cicadae 1400g, Cortex Dictamni 1000g, Radix Glycyrrhizae 1500g, Fructus Kochiae 1200g, Flos Buddlejae 1000g, Semen Celosiae 1200g, halite 1800g, white oak 1600g, Herba Pteridis Semipinnatae 1200g, Calamina 1200g, Herba Abri 1500g, add water extraction 2 times, by extracting solution thickening filtration, obtain extractum 1, medicinal residues are standby,

B, above-mentioned medicinal residues are added to 60-90% soak with ethanol 1 hour, extract twice, each 2 hours, merge extractive liquid,, 80-160 order filters, and 6000-10000 rev/min centrifugal, gets supernatant, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000, when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, 1.35 obtain extractum;

C, extractum 1 and extractum 2 is mixed, add 0.05% sodium chloride and the 80-100 distilled water doubly that mix extractum gross mass, and to add concentration be that to regulate PH be 6.5-7.5 to 5% sodium hydroxide solution, add again 0.2% active carbon to boil 10 minutes, filter packing, sterilizing, obtain the eye drop of 0.5g/ml, pack in the Plastic medicinal bottle of 10ml.

Embodiment 3 tablets

The preparation process of tablet of the present invention: extracting honeysuckle 1500g, Fructus Forsythiae 1200g, Folium Mori 1600g, puts into 85% ethanol, heating and refluxing extraction 2 times, each 1～2 hour, obtain extracting solution, medicinal residues are standby, by medicinal residues and Radix Isatidis 1500g, Spica Prunellae 1000g, Radix Saposhnikoviae 1200g, Herba Schizonepetae 1200g, Rhizoma Osmundae 1000g, Fructus Arctii 1500g, Rhizoma Phragmitis 1500g, Herba Taraxaci 1400g, Radix Scutellariae 1000g, Rhizoma Et Radix Notopterygii 1500g, Rhizoma Chuanxiong 1300g, Radix Angelicae Sinensis 1500g, Radix Rehmanniae 1500g, Radix Gentianae 1000g, Radix Paeoniae Rubra 1300g, Flos Chrysanthemi Indici 1000g, Periostracum Cicadae 1200g, Cortex Dictamni 1000g, Radix Glycyrrhizae 1500g, Fructus Kochiae 1800g, Flos Buddlejae 1000g, Semen Celosiae 1200g, halite 1200g, white oak 1500g, Herba Pteridis Semipinnatae 1300g, Calamina 1400g, Herba Abri 1600g, add 10 times of water gagings, heating and refluxing extraction 3 times, each 1 hour, 3 extracting solution are merged to obtain to extracting solution, by the extracting solution decompression recycling ethanol after merging and to be concentrated into liquor strength be 0.5g/mL, after sucking filtration, the relative density of filtrate is about 1.06 (20 ℃), the macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicinal liquid, add starch to be pressed into tablet.

 

Pharmacology pharmacodynamic test

1, acute toxicity test report

The capsule of the embodiment of the present invention 1 of take is object, getting the white mice of 20 identical health of vital sign tests, 20 white mice are divided into four groups, one group of matched group and three groups of test group, respectively 15 of test group white mice are carried out to feeding, medicine is mixed in the feedstuff of white mice, 20 white mice are controlled to same conditions of existence, first group is 1 multiple dose of clinical daily consumption, second group is 2 multiple doses, three groups is 3 multiple doses, then observe each group, by the observation after 24 hours, 10 white mice are still healthy, its activity, diet, hair, Excreta is no abnormal, have no toxic reaction.

2, long term toxicity test report

The tablet of the embodiment of the present invention 3 of take is object, selects 50 of adult rats, is divided at random 5 groups, one group of matched group and four groups of test group, 10 every group, male and female half and half.Test group is respectively organized 0.1(500m/K part BW that dosage is respectively LD50), 0.15(750m/K part BW), 0.22(1100m/K part BW), 0.34(1700m/K part BW), every day gavage once, continuous 20 days.Then observe 7 days.Each group of testing result is without dead, and each dosage group does not show death without dose-response relationship yet, and this medicine does not have obvious accumulative toxicity, and long-term taking can not have side effects.

3, hypersensitive test report

The eye drop of the embodiment of the present invention 2 of take is object, getting 30 healthy guinea pigs tests, male and female half-and-half, before administration, go both sides, back unhairing to process, be divided at random five groups, 6 every group, be respectively matched group, the high 1 multiple dose 0.5mg of damaged skin, low dosage 2 multiple dose 1mg groups, the high 1 multiple dose 0.5mg of intact skin, low dosage 2 multiple dose 1mg groups.Respectively to below four groups carry out after subcutaneous medication, once a day, continuous 7 days, observe each group situation, result Cavia porcellus all survives, and any discomfort do not appear in the skin of Cavia porcellus of each group, and the searching for food of Cavia porcellus, movable, breathing and body weight etc. do not occur obviously abnormal.Result demonstration, this medicine does not have sensitization.

Pharmacology pharmacodynamic test demonstration, this medicine does not have any toxic action, sensitization and untoward reaction, clinical use safety.

 

Clinical data

1. data and method

1.1 data

The acute conjunctivitis patient who has selected ，Wo institute treatment since year May in May, 2010 to 2011 is totally 200 examples.Wherein, male 110 examples, female's 90 examples, within 10 years old-25 years old, patient is 50 examples, and within 26 years old-40 years old, patient is 80 examples, and within 41 years old, above patient is 70 examples.Clinical manifestation is severe irritation and the watery secretion such as have violent pain, photophobia, shed tears; Eyelid is red and swollen, and conjunctiva height is congested, edema, point, lamellar or extensively hemorrhage under bulbar conjunctiva; Cornea fills the air point-like exuviation, and fluorescein is painted, before ear or submandibular lymph nodes enlargement.Patient is divided into two groups at random, treatment group and matched group, treatment group 120 people, matched group 80 people.

1.2 criterion of therapeutical effect

Cure: disease is cured, remove; Effective: disease is effectively alleviated, have obviously and alleviate; Invalid: disease affects without a bit.

1.3 test method

Treatment group is divided into three groups, adopts respectively the medicine of embodiments of the invention 1-3 to treat, matched group is divided into two groups, with conventional medicament, treats.

1.3.1 treatment group:

Treat one group: this is organized 40 people and adopts the capsule of the embodiment of the present invention 1 to treat.Take 0.5g as one, and three times on the one, once two 7 days is a course for the treatment of, and treatment is carried out 1-3 the course for the treatment of.After medication, after 36 people's symptoms, 2 people are effectively alleviated, and 2 people are invalid.In medication process, all there is not side effect.Follow up half a year, the not recurrence of recovery from illness.

Treat two groups: this is organized 40 people and adopts the eye drop of the embodiment of the present invention 2 to treat.The eye drop of configuration 0.5g/ml, packs in the Plastic medicinal bottle of 10ml, once drips 3-4 drip facing to canthus, and three times on the one 7 days is a course for the treatment of, and treatment is carried out 1-3 the course for the treatment of.After medication, after 37 people's symptoms, 2 people are effectively alleviated, and 1 people is invalid.In medication process, all there is not side effect.Follow up half a year, the not recurrence of recovery from illness.

Treat three groups: this is organized 40 people and adopts the tablet of the embodiment of the present invention 3 to treat.The tablet of 0.4g, three times on the one, once two 7 days is a course for the treatment of, treatment is carried out 1-3 the course for the treatment of.After medication, after 37 people's symptoms, 1 people is effectively alleviated, and 2 people are invalid.In medication process, all there is not side effect.Follow up half a year, the not recurrence of recovery from illness.

1.3.2 matched group:

Contrast one group: this is organized 40 people and adopts sulphacetamide to treat.Content 10%-20%, every 2-3 hour or per hour putting drops in one's eyes 1 time, treatment is carried out 4 weeks.In medication process, have 10 people to occur local irritation, as phenomenons such as burn feeling, pain, after medication, have 25 people's disease recoveries from illness, 7 people's diseases are alleviated, and 8 people are invalid.Follow up this year, 25 people of recovery from illness have 3 people's recurrences.

Contrast two groups: this is organized 40 people and adopts chlortetracycline to treat.Be applied in eyelid 1～2 time on the one.Treatment is carried out 4 weeks.In medication process, there are 8 people to occur contrafluxion, ophthalmic pruritus, the malaise symptoms such as edema, after medication, have 28 people's disease recoveries from illness, and 7 people's diseases are alleviated to some extent, and 5 people are invalid.With nearly half a year, there are 5 people's recurrences.

By contrast test, can learn, Chinese medicine composition of the present invention, compares with conventional medicament, the feature that have instant effect, good effect, have no side effect, recurrence effect is little.

2. concrete case

Case 1 Lee, female, 26 years old, suffers from acute conjunctivitis.Adopt the eye drop of the embodiment of the present invention 2 to treat.The eye drop of configuration 0.5g/ml, one time 3-4 drips, and three times on the one 7 days is a course for the treatment of, and treatment is carried out 2 courses for the treatment of, cures, in medication process, without sense of discomfort.

Case 2 grandsons, man, 40 years old, suffers from acute conjunctivitis.Adopt the capsule of the embodiment of the present invention 1 to treat.The capsule of 0.5g, three times on the one, once two 7 days is a course for the treatment of, and treatment was carried out after 3 courses for the treatment of, and disease recovery from illness, in medication process, without sense of discomfort.

Case 3 Zhangs, man, 30 years old, suffers from acute conjunctivitis.Adopt the tablet of the embodiment of the present invention 3 to treat.With the tablet amounts of 0.4g, three times on the one, once two 7 days is a course for the treatment of, and treatment is carried out 3 courses for the treatment of.In medication process, without sense of discomfort, after medication, disease recovery from illness.

 

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (9)

1. a Chinese medicine composition for the treatment of acute conjunctivitis, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of various crude drug is: 10～25 parts of Flos Loniceraes, 10～25 parts of Fructus Forsythiaes, 10～25 parts, Folium Mori, 10～25 parts of Radix Isatidis, 10～25 parts of Spica Prunellaes, 10～25 parts of Radix Saposhnikoviaes, 10～20 parts of Herba Schizonepetae, 10～20 parts of Rhizoma Osmundae, 10～20 parts of Fructus Arctiis, 10～20 parts of Rhizoma Phragmitiss, 10～25 parts of Herba Taraxacis, 10～20 parts of Radix Scutellariaes, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～25 parts of Rhizoma Chuanxiongs, 10～25 parts of Radix Angelicae Sinensis, 10～25 parts, the Radix Rehmanniae, 10～25 parts of Radix Gentianaes, 10～25 parts of Radix Paeoniae Rubra, 10～25 parts of Flos Chrysanthemi Indicis, 10～25 parts of Periostracum Cicadaes, 10～20 parts of Cortex Dictamni, 10～20 parts, Radix Glycyrrhizae, 10～20 parts of the Fructus Kochiae, 10～25 parts of Flos Buddlejaes, 10～20 parts of Semen Celosiae, 10～25 parts of halites, 10～20 parts of white oaks, 10～20 parts of Herba Pteridis Semipinnataes, 10～20 parts of 10～25 parts of Calaminas and Herba Abris.

2. the Chinese medicine composition for the treatment of acute conjunctivitis according to claim 1, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of various crude drug is: 10～15 parts of Flos Loniceraes, 20～25 parts of Fructus Forsythiaes, 10～25 parts, Folium Mori, 15～25 parts of Radix Isatidis, 20～25 parts of Spica Prunellaes, 10～20 parts of Radix Saposhnikoviaes, 10～15 parts of Herba Schizonepetae, 10～20 parts of Rhizoma Osmundae, 10～20 parts of Fructus Arctiis, 10～20 parts of Rhizoma Phragmitiss, 10～15 parts of Herba Taraxacis, 10～15 parts of Radix Scutellariaes, 15～20 parts of Rhizoma Et Radix Notopterygiis, 20～25 parts of Rhizoma Chuanxiongs, 20～25 parts of Radix Angelicae Sinensis, 10～15 parts, the Radix Rehmanniae, 10～25 parts of Radix Gentianaes, 10～25 parts of Radix Paeoniae Rubra, 10～20 parts of Flos Chrysanthemi Indicis, 10～15 parts of Periostracum Cicadaes, 10～15 parts of Cortex Dictamni, 15～20 parts, Radix Glycyrrhizae, 10～15 parts of the Fructus Kochiae, 20～25 parts of Flos Buddlejaes, 10～15 parts of Semen Celosiae, 10～20 parts of halites, 10～15 parts of white oaks, 15～20 parts of Herba Pteridis Semipinnataes, 15～20 parts of 10～25 parts of Calaminas and Herba Abris.

3. the Chinese medicine composition for the treatment of acute conjunctivitis according to claim 1 and 2, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of various crude drug is: 10～25 parts of Flos Loniceraes, 10～20 parts of Fructus Forsythiaes, 10～20 parts, Folium Mori, 10～20 parts of Radix Isatidis, 10～20 parts of Spica Prunellaes, 10～25 parts of Radix Saposhnikoviaes, 10～20 parts of Herba Schizonepetae, 15～20 parts of Rhizoma Osmundae, 10～15 parts of Fructus Arctiis, 15～20 parts of Rhizoma Phragmitiss, 10～20 parts of Herba Taraxacis, 10～20 parts of Radix Scutellariaes, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～25 parts of Rhizoma Chuanxiongs, 10～25 parts of Radix Angelicae Sinensis, 10～25 parts, the Radix Rehmanniae, 10～20 parts of Radix Gentianaes, 10～20 parts of Radix Paeoniae Rubra, 10～25 parts of Flos Chrysanthemi Indicis, 10～25 parts of Periostracum Cicadaes, 10～20 parts of Cortex Dictamni, 10～20 parts, Radix Glycyrrhizae, 10～20 parts of the Fructus Kochiae, 10～25 parts of Flos Buddlejaes, 10～20 parts of Semen Celosiae, 10～25 parts of halites, 10～20 parts of white oaks, 10～20 parts of Herba Pteridis Semipinnataes, 10～20 parts of 10～20 parts of Calaminas and Herba Abris.

4. a preparation method for the Chinese medicine composition of the treatment acute conjunctivitis as described in claim 1-3 any one, is characterized in that, described Chinese medicine composition dosage form is tablet, and described preparation method comprises:

A, by Flos Lonicerae, Fructus Forsythiae and Folium Mori are put into the ethanol heating and refluxing extraction of 60%-90%, obtain extracting solution 1;

B, get other crude drug again, add water heating and refluxing extraction, obtain extracting solution 2;

C, extracting solution 1 and extracting solution 2 merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain raw material medicinal liquid; Add dextrin or starch tabletting.

5. the preparation method of the Chinese medicine composition for the treatment of acute conjunctivitis according to claim 4, is characterized in that, in described step a, by Flos Lonicerae, Fructus Forsythiae and Folium Mori are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour.

6. the preparation method of the Chinese medicine composition for the treatment of acute conjunctivitis according to claim 4, is characterized in that, in described step b, crude drug described in other is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 30 minutes～1 hour.

7. the preparation method of the Chinese medicine composition for the treatment of acute conjunctivitis according to claim 4, it is characterized in that, in described step c, extracting solution 1 and extracting solution 2 are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicinal liquid; Add starch or dextrin tabletting.

8. a preparation method for the Chinese medicine composition of the treatment acute conjunctivitis as described in as arbitrary in claim 1-3, is characterized in that, the dosage form of described Chinese medicine composition is eye drop, and described preparation process is:

A, get described crude drug and add water extraction 2 times, by extracting solution thickening filtration, obtain extractum 1, medicinal residues are standby;

B, the medicinal residues of described step a are added to 60-90% soak with ethanol 1 hour, extract twice, each 2 hours, merge extractive liquid,, 80-160 order filters, and 6000-10000 rev/min centrifugal, gets supernatant, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000,1.35 extractum 2 when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃;

C, extractum 1 and extractum 2 is mixed, add 0.05% sodium chloride and the 80-100 distilled water doubly that mix extractum gross mass, and to add concentration be that to regulate PH be 6.5-7.5 to 5% sodium hydroxide solution, add again 0.2% active carbon to boil 10 minutes, filter packing, sterilizing, obtains eye drop.

9. according to the Chinese medicine composition of the treatment acute conjunctivitis described in claim 1-3 any one, it is characterized in that, the dosage form of described Chinese medicine composition is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder or patch.