CN103893722A - Traditional Chinese medicinal composition for treating solar dermatitis and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating solar dermatitis and preparation method thereof Download PDFInfo
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- CN103893722A CN103893722A CN201410113112.8A CN201410113112A CN103893722A CN 103893722 A CN103893722 A CN 103893722A CN 201410113112 A CN201410113112 A CN 201410113112A CN 103893722 A CN103893722 A CN 103893722A
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Abstract
The invention belongs to the technical field of medicines, and in particular relates to a traditional Chinese medicinal composition for treating solar dermatitis and a preparation method thereof. To overcome the defects of large hepatotoxicity and poor curative effect of a current chemical treatment medicament for treating solar dermatitis in the prior art, the traditional Chinese medicinal composition for treating or preventing solar dermatitis comprises the following components in parts by weight: 10-50 parts of purslane, 10-20 parts of notopterygium root, 5-20 parts of sophora flower, 5-15 parts of scutellaria baicalensis, 5-10 parts of prepared rehmannia root, 5-15 parts of lily, 5-15 parts of honeysuckle, 1-10 parts of dandelion, 5-15 parts of medlar, 9-15 parts of sculellaria barbata, 9-15 parts of ligusticum wallichii, 5-15 parts of angelica root, 0.2-9 parts of berberine, 5.5-15 parts of radix paeoniae alba, 6-9 parts of dried ginger and 10-15 parts of liquorice. The traditional Chinese medicinal composition has a good effect in preventing or treating solar dermatitis, has low toxic and side effects, and has a remarkable clinical popularization value.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine composition for the treatment of solar dermatitis and preparation method thereof.
Background technology
Allergy is a kind of allergy of body.After anaphylactogen (as chemical substance, ultraviolet, dust etc.) enters in body, be combined with mastocyte or basophilic granulocyte, produce leukotriene, the irritated factor such as prostaglandin, in the time that body is accepted this " anaphylactogen " for the second time, mastocyte starts distortion, produces allergic phenomena.Research shows, allergic dermatitis and free radical have direct relation.The essence of allergic dermatitis is the Oxidative demage reaction that produces a large amount of radical pair mastocytes and basophil in body.So-called free radical, exactly in the time that body carries out metabolism, can seize an electronics of oxygen, and this oxygen atom just becomes free radical like this.Free radical is very unstable, it will capture electronics in the molecule of bodily tissue cell again makes oneself pairing, and when after the moving electronics of cellular elements, it also becomes free radical, go again to grab cell membrane or or nucleus molecule in electronics, claim so again to produce new free radical.As, superoxide anion radical, hydroxy radical, hydroperoxyl radical and methyl free radicals, etc.Allergic dermatitis (allergic dermatitis) is the skin allergy causing due to contact hypersensitivity antigen (as hundreds of kinds such as chemical substance, ultraviolet, pollen, dust, foreign proteins), and it is mainly the I allergic reaction type being mediated by IgE.The skin disorders such as that skin occurs is red and swollen, itch, welt, decortication.The main dermoreactions such as dermatitis, eczema, urticaria that show as.
Common allergic dermatitis mainly contains: contact dermatitis, solar dermatitis, cosmetic dermatitis, steroid-dependent dermatitis etc.At present, the Western medicine for the treatment of solar dermatitis is a lot, but most drug therapeutic effect is poor, and treats in addition the shortcomings such as high, side effect is large, even affects patient health when serious.In addition, also have the Chinese medicine of a lot for the treatment of solar dermatitis, but the shortcoming such as great majority have that therapeutic effect is poor, cure rate is low and treatment cycle is long.The object of the invention is to provide a kind of effect comprehensively, the Chinese medicine composition of the treatment solar dermatitis that clinical effectiveness is good.
The traditional Chinese medical science thinks, solar dermatitis is because body natural endowment is not strong, skin interspaces of skin and muscles being loose, and Dermal exposure position, after daylight excessively irradiates, is invaded in summer-heat poison, and pathogenic heat are fought mutually with QI and blood and are fallen ill.Be mainly in spring and summer season, show as body exposure position and occur difform erythema, pimple, welt or vesicle as face, cervical region, the back of the hand etc., accompany local pruritus, scorching hot twinge, severe patient can cause the General Symptomies such as heating, headache, nauseating, vomiting.Its characteristics of incidence is that after sun exposure, skin lesion obviously increases the weight of, gargalesthesia aggravation, and after lucifuge, symptom alleviates.One is mainly to rely at present Western medicine to treat at present solar dermatitis, and side effect is large, and dependency is strong, causes dose increasing, causes vicious cycle.
Make a general survey of the research direction of world's new drug, be mainly single chemicals and preparations thereof of research and development the eighties in the past, starts to develop biotechnology and natural medicinal plants after the eighties, and drug research direction is tending towards multiformity.In conjunction with modern Chinese medicine theory of development, from improving the angle of curative effect of medication, reduction side effect, through Chinese medicine ingredients being screened to the preparation that extraction and/or compatibility make, its side effect is little, safe, has the advantage that chemical synthetic drug can not be compared.
Summary of the invention
In prior art, chemicals is cured the symptoms, not the disease, and easily damages gastrointestinal tract mucously, and poisonous side effect of medicine is large, and Chinese medicine exists uncertain therapeutic efficacy fixed, lacks relative medicine preparation.Large in order to overcome existing solar dermatitis chemotherapeutic agent toxic and side effects, solar dermatitis therapeutic effect is difficult to lasting prior art deficiency, the invention provides a kind of Chinese medicine composition for the treatment of solar dermatitis, this Chinese medicine composition good effect, side effect is little, it is mainly made by following raw material: Herba Portulacae 10-50 part, Rhizoma Et Radix Notopterygii 10-20 part, Flos Sophorae 5-20 part, Radix Scutellariae 5-15 part, Radix Rehmanniae Preparata 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Herba Taraxaci 1-10 part, Fructus Lycii 5-15 part, Herba Scutellariae Barbatae 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, berberine 0.2-9 part, Radix Paeoniae Alba 5.5-15 part, Rhizoma Zingiberis 6-9 part, Radix Glycyrrhizae 10-15 part.
Herba portulacae has heat-clearing and toxic substances removing, damp eliminating leukorrhagia stopping effect, is applicable to that damp invasion of lower energizer, leucorrhea with yellow discharge, sticky taste are smelly, oliguria with yellow urine, thirsty bitter taste, red tongue with yellow fur, rolling pulse person, also can be used for diarrhea due to damp-heat, dysentery etc.Energy insect-expelling function, is applicable to infantile ancylostomiasis.These product have heat-clearing and toxic substances removing, antidiarrheal dysentery, remove intestinal dirt, QI invigorating tonify deficiency effect, are applicable to treat chronic dysentery.
Rhizoma Et Radix Notopterygii is conventional Chinese medicine.Medicinal history is long, first appeared in Shennong's Herbal, lists under Radix Angelicae Pubescentis item.Rhizoma Et Radix Notopterygii bitter in the mouth, pungent, warm in nature.There is loose exterior cold curing rheumatism, the effect in sharp joint.Control affection of exogenous wind-cold, lossless, the anemofrigid-damp arthralgia of having a headache, stiffness of the nape muscular contracture, joint are ached, edema due to wind pathogen edema, the swollen sore of pain etc.Modern analysis shows, Rhizoma Et Radix Notopterygii mainly contains bornene, twists rubber alkene, the compositions such as words product enol and acetic acid Radix Gentianae brain vinegar.Clinical in impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.The diseases such as cold expelling, expelling wind and dampness, pain relieving of inducing sweat.Modern pharmacology research Rhizoma Et Radix Notopterygii has significant antipyretic and anti-inflammatory and paroxysmal pain effect.
Flos Sophorae is again Chinese scholartree stamen, effect of Flos Sophorae: cooling blood for hemostasis, liver heat removing and eyesight improving, Flos Sophorae effect: control discharging fresh blood stool, hemorrhoid hematochezia, hematuria stranguria with blood, liver-heat headache, conjunctival congestion and swelling pain, Flos Sophorae medication taboo: the careful Flos Sophorae that takes of Deficiency and coldness of spleen and stomach person, Flos Sophorae can (drugs) to be decocted and taken as a drink, Flos Sophorae also can be equal to use with Spica Prunellae, Flos Chrysanthemi, Radix Scutellariae, to increase the effect of purging liver-fire improving eyesight.Clinical curing mainly: discharging fresh blood stool; Hemorrhoid hematochezia; Dysentery; Hematuria; Stranguria with blood; Metrorrhagia; Spit blood; Epistaxis; Liver-heat headache; Conjunctival congestion and swelling pain; Carbuncle skin infection.
Radix Scutellariae another name Radix Scutellariae, tsuchikane tea root.For labiate Radix Scutellariae (Scutellaria baicalensis Georgi), be used as medicine with root.Have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Chuanxiong, and does not develop immunity to drugs.
Radix Rehmanniae Preparata is the tuber of scrophulariaceae rehmannia glutinosa plant, has another name called Radix Rehmanniae Preparata or throws oneself on the ground, and concocts and forms through processing.Radix Rehmanniae Preparata is a kind of first-class Chinese crude drug, has the YIN nourishing of enriching blood effect, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, the disease such as pass out semen, quench one's thirst, and are one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main components.Radix Rehmanniae Preparata is first appeared in Shennong's Herbal, and clinical use has fresh, raw, ripe three kinds.All there is the merit of YIN nourishing and the production of body fluid promoting, and control all cards of Yin and fluid deficiency.Radix Rehmanniae sweetness and bitterness Great Cold, though a little less than the power of YIN nourishing, be longer than clearing away heat and cooling blood, pathogenic fire purging relieving restlessness, is used for that heat in blood is evil contains, syndrome of yin deficiency and depletion of fluid; The power of the sweet cold matter profit removing heat from blood of raw (do) Radix Rehmanniae is slightly inferior but be longer than the moon of the kidney that nourishes heart, Gu Xuereyin injure fever due to yin deficiency person suitable it; Radix Rehmanniae Preparata is sweet in flavor and warm in property, enters Liver and kidney and the special nourishing the blood and yin of merit, life essence-filling, marrow-benefitting, and all kidney-YIN being deficient, marrow virtual loss person, all can use it.Radix Rehmanniae Preparata is for insufficiency of kidney-YANG, decline of the fire from the gate of life, and aversion to cold and cold limbs, impotence and seminal emission, urine is lost drop, or the anorexia and loose stool of YANG failing to warm spleen-YANG, the product adapted of the warming YANG such as many and Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, this i.e. the meaning of so-called " be apt to YANG invigorating person, must in treating YANG within YIN ".With controlling carbuncle of yin nature cold coagulation, the adapteds such as the normal and Colla cornus cervi of this product, Cortex Cinnamomi, Herba Ephedrae are with channel warming and blood nourishing, and cold expelling is promoted blood circulation.
The traditional Chinese medical science thinks that Bulbus Lilii has the effect of nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, and especially fresh Bulbus Lilii is more sweet delicious.The people that Bulbus Lilii is particularly suitable for foster lung, nourishing the stomach eats, such as the patient of chronic cough, pulmonary tuberculosis, aphtha of the mouth and tongue, xerostomia, halitosis.Bulbus Lilii not only has good nutritious tonifying effect, and for the patient such as deficient syndrome, tuberculosis, neurosis is of great advantage after being ill, various cancers is had to good curative effect.Aspect the prevention and treatment of tumor, Bulbus Lilii is used for treating pulmonary carcinoma, nasopharyngeal carcinoma, skin carcinoma etc.When the symptoms such as, xerostomia weak in the body void that above-mentioned cancer is carried out occurring after radiotherapy, vexed, dry cough expectorant, cook congee together with Semen oryzae sativae with fresh Bulbus Lilii, after calling in again appropriate crystal sugar or Mel, eat, to the reaction of health invigorating, anticancer growth, alleviation radiotherapy, there is good effect.For another example, fresh Bulbus Lilii and white sugar are smash to deposited affected part in right amount altogether,, infiltration person hemorrhage to skin carcinoma ulceration also has certain therapeutical effect.
Flos Lonicerae is cold in nature, and sweet in the mouth enters lung, the heart, stomach warp, has effect of heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treatment wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, gastroenteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae tea has unique weight losing function simultaneously, can also suppress and the pathogen of killing bottleneck throat, and old man and child are had to infection effect.So, often take Flos Lonicerae immersion or decoct and be conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the hypertensive treatment of liver-heat disease regulating liver-QI pattern of fever and rehabilitation.
Herba Taraxaci has the effect of heat-clearing and toxic substances removing, can be used for pyretic toxicity card, especially kind removing heat from the liver, treatment liver-heat conjunctival congestion and swelling pain, and multi-infection, purulent disease; Eliminating carbuncle eliminating stagnation treatment pyretic toxicity is stopped up the carbuncle sore tumefacting virus of tying due to the muscle, hyperpyrexia.Acute mastitis is had to good effect, energy detoxicating and resolving stagnation of pathogens lactogenesis, oral administration or external application, often join Flos Lonicerae and be equal to use.Also can join in addition Radix Et Rhizoma Rhei, Cortex Moutan treatment acute appendicitis.
Fructus Lycii (formal name used at school: Lycium chinense) is the multi-branched shrub plant of Solanaceae Lycium, and high 0.5-1 rice, can reach more than 2 meters when cultivation.All there is distribution both at home and abroad.Fructus Lycii whole body is precious, and bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is recorded: " spring is adopted Folium Lycii, name day essence grass; Summer picks flowers, name Sempervivum tectorum; Qiu Caizi, name Fructus Lycii; Dong Caigen, name Cortex Lycii ".Fructus Lycii tender leaf also claims Fructus Lycii head, edible or make Fructus Lycii tea.Modern study, Fructus Lycii has the blood glucose of reduction, lipotropy, and can antiatherogenic effect.
Herba Scutellariae Barbatae is the dry aerial parts of labiate Herba Scutellariae Barbatae, tool heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, the function such as anticancer.Main and Herba Hedyotidis Diffusae is used in conjunction with now, is used for extending the existence life-span of patients with bowel cancer.Meanwhile, Herba Scutellariae Barbatae heat-clearing and toxic substances removing, dissipating blood stasis, hemostasis, analgesic therapy, cancerous protuberance, traumatic injury knife injury, venom etc.
The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, the up top, mountain peak that reaches; Enter again blood system, the descending sea of blood that reaches.Blood circulation promoting and blood stasis dispelling effect is extensive, the various diseases of suitable stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is the gas medicine in blood that former times people calls Rhizoma Chuanxiong, nearly says the functions such as pungent loose, the resolving depression of its residence, sensible, pain relieving.The pungent temperature rise of this product is loose, and all hyperactivity of YANG due to deficiency of YIN and excessive rising of liver-YANG person should not apply; Menorrhagia, anemia of pregnant woman also avoid use.
The Radix Angelicae Dahuricae, warm in nature, acrid in the mouth is micro-sweet, has expelling wind and removing dampness; Logical surreptitiously pain relieving; Effect of detumescence and apocenosis.Main headache due to common cold; Supraorbital bone pain; Toothache; Nasal obstruction; Nasal sinusitis; Domination of damp pathogen chronic diarrhea; Women leucorrhea; Ulcer sores; Venom.Clinical in headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.Also can be used for the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Rhizoma Atractylodis have drying damp and strengthening spleen, expelling wind and cold, and effect of improving eyesight, for dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.Control dampness taste, and see the thick disease such as turbid of distension and fullness in the abdomen, inappetence, fatigue and weakness, white and greasy fur, the compatibilities such as normal and Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae are applied.
Berberine is used for the treatment of diarrhoea as nonprescription drugs in clinical always, modern pharmacology there is significant heart failure resistance, arrhythmia, reduction cholesterol, anti-vascular smooth muscle cell proliferation processed, improve the effects such as insulin resistant, antiplatelet, antiinflammatory but studies confirm that berberine, thereby unify aspect nervous system disease and may have extensive, important application prospect at cardiovascular system, day by day come into one's own.Berberine is a kind of important alkaloid, is that China applies Chinese medicine for a long time.Can from the plants such as Rhizoma Coptidis, Cortex Phellodendri, Radix Berberidis, extract.It has significant bacteriostasis.Conventional berberine hydrochloride is again berberine hydrochloride.Berberine energy enantiopathy pathogenic microorganism, various bacteria is had to inhibitory action as dysentery bacterium, tubercule bacillus, streptococcus pneumoniae, Bacillus typhi and diphtheria corynebacterium etc., wherein the strongest to dysentery bacterium effect, be commonly used to treat the digestive tract disease such as bacillary gastroenteritis, dysentery.Clinically be mainly used in treating bacillary dysentery and gastroenteritis, it is without Drug resistance and side effect.
The Radix Paeoniae Alba is the famous traditional parts of generic medicinal plants of China, and applicating history is long, and Radix Paeoniae begins to be loaded in Eastern Han Dynasty's Shennong's Herbal, classifies middle product as, and note has " main pathogen, Radix Paeoniae Alba stomachache, removes arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating ".Nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior disease.Modern pharmacology studies show that, the intestine in vitro of paeoniflorin to Cavia porcellus, rat and in stomach motion, and rat uterus smooth muscle all shows inhibition, and can pick up the caused contraction of anti-oxytocin; With acetic acid injection in mouse peritoneal, the index using writhing response as pain, paeoniflorin has significant analgesic effect; The extractum of Radix Paeoniae can be picked up the caused convulsions of anti-strychnine; Radix Paeoniae Alba decoct has bacteriostasis to dysentery bacterium in vitro, and preserved material also has inhibitory action to some pathogenic fungus.Paeoniflorin has cooling effect to white mice normal body temperature, and the mice of artificial fever is also had to refrigeration function.Rat experiment metapedes sole of the foot edema is had to antiinflammatory action; Paeoniflorin has inhibitory action to the rat platelet aggregation of adenosine diphosphate (ADP) induction in vitro or when intravenous injection; Paeoniflorin has obvious inhibitory action to the digestive tract in rats ulcer of bringing out due to tense and stimulation.
Rhizoma Zingiberis Shennong's Herbal is classified middle product as, and Rhizoma Zingiberis Recens " Mingyi Bielu " is classified middle product as.TAO Hong-Jing meaning: " all Rhizoma Zingiberis methods of doing: water logging three days, peeling is put in flowing water six, and more random peeling, then dries, and puts in Porcelain Jar and makes three, is into." Li Shizhen (1518-1593 A.D.) meaning Rhizoma Zingiberis makes it with female Rhizoma Zingiberis Recens, take fair and clear solid person as good, all being used as medicine and Yi Pao use.Rhizoma Zingiberis, for warm spleen sun, is partially controlled spleen-cold syndrome stomachache and has loose bowels.Can promote blood circulation by recuperating depleted YANG again, warming the lung to resolve fluid-retention, with controlling yang depletion syndrome, extremity are fainted contrary, faint pulse being about to disappear, and cold fluid-retention cough with asthma, the cold physique back of the body is cold, the clear rare disease of waiting of abundant expectoration.
Chinese medicine composition of the present invention take except long-pending numbness, dispersing wind and cold, wind-damp dispelling, bone and muscle strengthening are as main standard, has significant antiinflammatory, analgesia and activating blood circulation to dissipate blood stasis effect after Chinese medicine composition combination of the present invention on Chinese medicinal components is selected.The present invention has carried out preferably the parts by weight of above-mentioned all taste Chinese medicine, and preferred condition is the enhancing of medicine to solar dermatitis therapeutic effect after Chinese medicine and western medicine compatibility uses.As a preferred embodiment of the present invention, Chinese medicine composition of the present invention is mainly made by the raw material of following weight portion: 30 parts of Herba Portulacaes, 15 parts of Rhizoma Et Radix Notopterygiis, 15 parts, Flos Sophorae, 10 parts of Radix Scutellariaes, 8 parts, Radix Rehmanniae Preparata, 10 parts of Bulbus Liliies, 10 parts of Flos Loniceraes, 6 parts of Herba Taraxacis, 10 parts of Fructus Lyciis, 12 parts of Herba Scutellariae Barbataes, 12 parts of Rhizoma Chuanxiongs, 10 parts of the Radixs Angelicae Dahuricae, 5.5 parts of berberines, 10 parts of the Radix Paeoniae Albas, 8 parts of Rhizoma Zingiberiss, 12 parts, Radix Glycyrrhizae.
Preferably, Chinese medicine composition of the present invention also further contains 5 parts of Fructus Citris, 9 parts of Radix Polygalaes.Fructus Citri has another name called citron, is Rutaceae citrus plant, and Fructus Citri acrid in the mouth, micro-hardship, acid are warm in nature; Return liver, lung, spleen channel; The fragrant row of gas is loose, can rise and can fall; Have depressed liver-energy dispersing and QI regulating, the chest stuffiness relieving reduces phlegm, dehumidifying and in effect, cure mainly distending pain in the chest and hypochondrium, cough with copious phlegm, gastral cavity abdomen painful abdominal mass pain, dyspepsia vomiting, edema beriberi.Radix Polygalae is conventional Chinese medicine, be recorded in the earliest Shennong's Herbal, classify as top grade, and be regarded as support life key medicine, warm in nature, bitter in the mouth, pungent, the function of there is the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep causing for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
For better expression Chinese medicine composition of the present invention, the present invention can be prepared into conventional clinically dosage form.Such as, the preparations such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule.Preferably, Chinese medicine composition of the present invention is prepared into powder, gel, tablet or capsule according to conventional preparation technology.
The present invention also provides a kind of preparation method of Chinese medicine composition described above, comprise following step: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, doubly adding volumetric concentration according to the 4-9 of coarse powder gross weight is the alcoholic solution of 40%-95%, reflux, extract, three times, return time is 2-5h, filters, filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; After being made to dried cream powder, its pulverizing add the berberine of recipe quantity and Herba Taraxaci can obtain Chinese medicine composition of the present invention.Those skilled in the art can be at the technical conventional Chinese medicine pharmaceutical dosage form clinically for preparing of this preparation method, as tablet, capsule etc.
The present invention also asks to protect the purposes of above-mentioned Chinese medicine composition in preparation treatment solar dermatitis medicine.Pharmaceutical composition of the present invention, in the time for the treatment of solar dermatitis, demonstrates significant anti-inflammatory and antalgic, activating blood circulation to dissipate blood stasis activity.Drug effect embodiment 19 of the present invention shows, with model group comparison, the low middle Senior Three of a Chinese medicine composition of the present invention dosage group all can significantly reduce the ear swelling value (P < 0.01) of dimethylbenzene induced mice, show that Chinese medicine composition of the present invention has the effect of the mice ear of remarkable inhibition dimethylbenzene induction, and there is significant dose-effect relationship in its reduction effect to ear swelling.Under same experiment condition, positive control drug chlorphenamine group also significantly reduces ear swelling value (P < 0.05), but its antiphlogistic effects is obviously not as good as Chinese medicine composition of the present invention.
In a word, pharmaceutical composition of the present invention, aspect treatment solar dermatitis, compared with prior art has following advantage:
1) compared with positive control drug, pharmaceutical composition Chinese medicine composition of the present invention is not only more remarkable at antiinflammatory and ease pain, and aspect activating blood circulation to dissipate blood stasis, be also significantly better than positive drug, this shows that the present composition has significant synergism in solar dermatitis treatment, not only can significantly improve the symptom of solar dermatitis, can also delay the development of solar dermatitis, contribute to solar dermatitis patient's recovery from illness process;
2) compared with the chemotherapeutic agent of current treatment solar dermatitis, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, particularly it does not produce any destruction for intestinal mucosa, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, has significantly improved solar dermatitis patient's compliance, and has improved patient's quality of life.
The specific embodiment
Further describe the present invention by specific embodiment below, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, change, combination or replacement that the present invention is carried out, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Part I Chinese medicinal composition preparation of the present invention, preparation and using method thereof
Embodiment 1-6 Chinese medicine composition composition powders
Table 1 Chinese medicine composition composition powders prescription of the present invention
Embodiment 1 preparation method: get each medical material in compositions, grind to form powdery according to common process, cross 100 mesh sieves, little fire drying is for subsequent use, obtains powder.When use, with directly taking after mixing it with water after water dissolution.Embodiment 2-6 preparation method is with embodiment 1.
Embodiment 7-12 Chinese medicine composition gelata
Table 2 Chinese medicine composition gelata prescription of the present invention
Embodiment 7 preparation methoies: get each medical material in prescription, according to conventional decocting for Chinese herbal medicine technological operation, add appropriate glyceryl monostearate and dimethicone after filtering medicinal residues and get final product.When this gel (or claiming decoction) is treated for solar dermatitis, smear 2-3 every day.Embodiment 8-12 preparation method and using method are with embodiment 7.
Embodiment 13-18 Chinese medicine composition tablet/capsule of the present invention
Table 3 Chinese medicine composition tablet of the present invention/capsule prescription
Embodiment 13 preparation technologies: each traditional Chinese medicine powder of getting recipe quantity is broken into coarse powder, adding volumetric concentration according to 5 times of coarse powder gross weight is 80% alcoholic solution, reflux, extract, three times, the each 3h of return time, filters filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Chinese medical concrete drying, pulverizing are made to dried cream powder, then added conventional adjunct ingredient to utilize prior art to be prepared into tablet or capsule.
Embodiment 14-18 preparation technology is with embodiment 13.
Part II Chinese medicine composition pharmacodynamic study of the present invention
Embodiment 19 Chinese medicine composition xylol of the present invention causes the impact of mice ear
Get 72 of healthy ICR mices, ♀ ♂ half and half, divide 6 groups, 12/group, be model group, hydrocortisone (Hainan company limited of SANYE pharmaceutical factory, lower same), chlorphenamine group (Haikou Kangliyuan Pharmaceutical Co., Ltd), Chinese medicine composition of the present invention (making by Chinese medicine composition prescription and preparation technology described in embodiment 1) low dose group, middle dosage group and high dose group.1 time/d of every ig administration; Administration 14d, 60min after last medicine, mouse right ear is evenly smeared dimethylbenzene 0.03mL/ and is only caused swollenly, cuts ears and beat auricle and weigh after 2h, calculates ear swelling value (mg).Swelling value=auris dextra weight-left ear weight.
Result shows, with model group comparison, the low middle Senior Three of a Chinese medicine composition of the present invention dosage group all can significantly reduce the ear swelling value (P < 0.01) of dimethylbenzene induced mice, show that Chinese medicine composition of the present invention has the effect of the mice ear of remarkable inhibition dimethylbenzene induction, and there is significant dose-effect relationship in its reduction effect to ear swelling.Under same experiment condition, positive control drug chlorphenamine group also significantly reduces ear swelling value (P < 0.05), but its antiphlogistic effects is obviously not as good as Chinese medicine composition of the present invention.
The impact of table 4 Chinese medicine composition xylol of the present invention induced mice ear swelling
Note: with model group comparison, * P < 0.05, * * P < 0.01.
The skin photoage that embodiment 20 Chinese medicine composition of the present invention causes ultraviolet and the impact of hydroderma
The protective effect of the skin photoage that 20.1 Chinese medicine compositions of the present invention cause ultraviolet
Mice is divided into 6 groups at random: model group gives gel-type vehicle, present composition gel prepared by embodiment 7 is divided into high and low dose group, and positive controls 1 gives vitamin E; Positive controls 2 gives chlorphenamine; Positive controls 3 gives adapalene gel.Mouse back depilation before experiment, exposed area 4cm × 3cm, respectively organizes the preventative 3d of smearing.Mice is placed in (5 of 40W UVA tubes, 2 of UVB fluorescent tubes) under uviol lamp, irradiates apart from skin 35cm place, and between the light period, paper using is pulled and covered animal head.Initial irradiation time is 4h/d, is increased to gradually 12h/d, Continuous irradiation 4 weeks, perusal record the situation of change of skin in the process of irradiating.
The impact of the hydroderma that 20.2 Chinese medicine compositions of the present invention cause ultraviolet
Mice is divided into 6 groups at random: model group gives gel-type vehicle, present composition gel prepared by embodiment 1 is divided into high and low dose group, and positive controls 1 gives prednisolone acetate ointment (Tianjin Pharmaceutical Group Corp., Ltd); Positive controls 2 gives chlorphenamine; Positive controls 3 gives adapalene gel.Mouse back depilation before experiment, exposed area 4cm × 3cm; The preventative 7d that smears of each group.Mice is horizontally fixed on brandreth, and (Continuous irradiation 6h, covers animal head with cardboard between the light period for 4 of 40WUVA fluorescent tubes, 16 vertical dimension 10cm of UVB fluorescent tube with uviol lamp.40h after irradiating, disconnected ridge is put to death mice, get respectively two ears (d=0.7cm) and back (d=2cm) the circular skin graft through irradiating, accurately take ear weight, tare weight and body weight, calculate ear exponential sum skin index: { heavy (the mg)/body weight of ear (skin) index=ear (skin) (g) × 100}.
20.2.1 result
20.2.1.1 perusal
Irradiating after 4d, there is serious large redness, desquamation in the illuminated skin of model group mice; Vitamin E and present composition gel group, chlorphenamine group, adapalene gel group skin injury situation are light compared with model group, and desquamation phenomenon is less.Wherein present composition gel group redness, desquamation phenomenon are lighter than chlorphenamine group and adapalene gel group.
Irradiate after 15d, there is large area lamellar erythema, fester in the illuminated skin of model group mice, incrustation, local skin thicken; Vitamin E, present composition gel group and chlorphenamine group skin injury situation are light compared with model group, and erythema is few, ulceration is lighter.Wherein present composition gel group effect is better than chlorphenamine group and adapalene gel group.
Irradiate after 24d, the illuminated skin of model group mice presents lamellar erythema, festers, vesicle, thicken, tarnish and elasticity, aging obviously; Vitamin E, present composition gel group and chlorphenamine group, adapalene gel group skin injury situation are light compared with model group, and erythema is few, ulceration is light, vesicle quantity is few, pachyderma is not obvious.Wherein present composition gel group is slight compared with chlorphenamine group, adapalene gel group ulceration, and vesicle quantity is few, and vesicle is little.
20.2.1.2 the impact of hydroderma
As can be seen from Table 5: present composition gel group can reduce mouse ear index, skin index, difference is very significant (P < 0.01), and its effect is better than chlorphenamine group.
The impact of table 5 on mouse ear index, skin index
With relatively * * P < 0.01 of model group, * P < 0.05, with relatively △ △ P < 0.01 of chlorphenamine group, △ P < 0.05;
With relatively ☆ ☆ P < 0.01 of adapalene gel group, ☆ P < 0.05, with prednisolone acetate group comparison ▲ ▲ P < 0.01, ▲ P < 0.05.
Result shows, the therapeutic effect of present composition preparation is better than chlorphenamine and adapalene gel.
Claims (6)
1. treat a Chinese medicine composition for solar dermatitis, it is characterized in that it is mainly made by the raw material of following weight portion: Herba Portulacae 10-50 part, Rhizoma Et Radix Notopterygii 10-20 part, Flos Sophorae 5-20 part, Radix Scutellariae 5-15 part, Radix Rehmanniae Preparata 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Herba Taraxaci 1-10 part, Fructus Lycii 5-15 part, Herba Scutellariae Barbatae 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, berberine 0.2-9 part, Radix Paeoniae Alba 5.5-15 part, Rhizoma Zingiberis 6-9 part, Radix Glycyrrhizae 10-15 part.
2. the Chinese medicine composition for the treatment of solar dermatitis as claimed in claim 1, is characterized in that it is mainly made by the raw material of following weight portion: 30 parts of Herba Portulacaes, 15 parts of Rhizoma Et Radix Notopterygiis, 15 parts, Flos Sophorae, 10 parts of Radix Scutellariaes, 8 parts, Radix Rehmanniae Preparata, 10 parts of Bulbus Liliies, 10 parts of Flos Loniceraes, 6 parts of Herba Taraxacis, 10 parts of Fructus Lyciis, 12 parts of Herba Scutellariae Barbataes, 12 parts of Rhizoma Chuanxiongs, 10 parts of the Radixs Angelicae Dahuricae, 5.5 parts of berberines, 10 parts of the Radix Paeoniae Albas, 8 parts of Rhizoma Zingiberiss, 12 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of solar dermatitis as claimed in claim 2, is characterized in that it also contains the raw material of following weight portion: 9 parts of 5 parts of Fructus Citris and Radix Polygalaes.
4. the Chinese medicine composition of the treatment solar dermatitis as described in as arbitrary in claim 1-3, is characterized in that: it is powder, gel, tablet or capsule.
5. prepare the method for the Chinese medicine composition for the treatment of solar dermatitis as claimed in claim 4 for one kind, it is characterized in that it comprises the following steps: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, doubly adding volumetric concentration according to the 4-9 of coarse powder gross weight is the alcoholic solution of 40%-95%, reflux, extract, three times, return time is 2-5h, filter, filtrate recycling ethanol, cold filtration, wash with water, after dry, obtain Chinese medical concrete, add the berberine of recipe quantity and Herba Taraxaci can obtain Chinese medicine composition of the present invention after its pulverizing is made to dried cream powder.
6. the Chinese medicine composition as described in as arbitrary in claim 1-3 is purposes in preparation treatment solar dermatitis medicine.
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| CN201610155352.3A CN105688160A (en) | 2014-03-25 | 2014-03-25 | Application of traditional Chinese medicine composition in preparation of drug for treating solar dermatitis |
| CN201410113112.8A CN103893722B (en) | 2014-03-25 | 2014-03-25 | A kind of Chinese medicine composition and its preparation method treating sunburn |
| CN201610155331.1A CN105688159A (en) | 2014-03-25 | 2014-03-25 | Method for preparing traditional Chinese medicine composition for treating solar dermatitis |
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| CN201410113112.8A CN103893722B (en) | 2014-03-25 | 2014-03-25 | A kind of Chinese medicine composition and its preparation method treating sunburn |
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| CN201610155331.1A Division CN105688159A (en) | 2014-03-25 | 2014-03-25 | Method for preparing traditional Chinese medicine composition for treating solar dermatitis |
| CN201610155352.3A Division CN105688160A (en) | 2014-03-25 | 2014-03-25 | Application of traditional Chinese medicine composition in preparation of drug for treating solar dermatitis |
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| CN201610155352.3A Withdrawn CN105688160A (en) | 2014-03-25 | 2014-03-25 | Application of traditional Chinese medicine composition in preparation of drug for treating solar dermatitis |
| CN201610155331.1A Withdrawn CN105688159A (en) | 2014-03-25 | 2014-03-25 | Method for preparing traditional Chinese medicine composition for treating solar dermatitis |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104740566A (en) * | 2015-03-26 | 2015-07-01 | 鼎旺生物科技有限公司 | Preparation for relieving skin inflammation, and preparation method and application thereof |
| CN104984046A (en) * | 2015-06-25 | 2015-10-21 | 湖北中医药大学 | Traditional Chinese medicine external preparation for treating allergic dermatitis and preparing method thereof |
| CN105168532A (en) * | 2015-07-23 | 2015-12-23 | 青岛蓝盛洋医药生物科技有限责任公司 | Pharmaceutical composition for treating solar dermatitis and preparation method of pharmaceutical composition |
| CN105213570A (en) * | 2015-09-29 | 2016-01-06 | 罗奕珺 | A kind of pharmaceutical composition for the treatment of solar dermatitis and preparation method thereof |
| CN105232758A (en) * | 2015-10-10 | 2016-01-13 | 临沂草之美医药科技有限公司 | Solar dermatitis treating pharmaceutical composition and preparation method thereof |
| CN105311427A (en) * | 2015-11-18 | 2016-02-10 | 暨南大学 | Pharmaceutical composition containing folium artemisiae argyi for treating solar dermatitis |
| CN105327032A (en) * | 2015-11-26 | 2016-02-17 | 王辉 | Traditional Chinese medicine composition for treating solar dermatitis, preparation method and use method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815303A (en) * | 2018-09-03 | 2018-11-16 | 文勇 | A kind of composition and preparation method thereof for treating prostatitis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488791A (en) * | 2011-12-11 | 2012-06-13 | 王英婷 | Chinese traditional medicine granule for eczema and dermatitis |
-
2014
- 2014-03-25 CN CN201410113112.8A patent/CN103893722B/en active Active
- 2014-03-25 CN CN201610155352.3A patent/CN105688160A/en not_active Withdrawn
- 2014-03-25 CN CN201610155331.1A patent/CN105688159A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488791A (en) * | 2011-12-11 | 2012-06-13 | 王英婷 | Chinese traditional medicine granule for eczema and dermatitis |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104740566A (en) * | 2015-03-26 | 2015-07-01 | 鼎旺生物科技有限公司 | Preparation for relieving skin inflammation, and preparation method and application thereof |
| CN104740566B (en) * | 2015-03-26 | 2018-05-29 | 鼎旺生物科技有限公司 | A kind of preparation for mitigating scytitis, preparation method and applications |
| CN104984046A (en) * | 2015-06-25 | 2015-10-21 | 湖北中医药大学 | Traditional Chinese medicine external preparation for treating allergic dermatitis and preparing method thereof |
| CN104984046B (en) * | 2015-06-25 | 2019-02-26 | 湖北中医药大学 | A kind of traditional Chinese medicine for external application and preparation method thereof for treating anaphylaxis dermatosis |
| CN105168532A (en) * | 2015-07-23 | 2015-12-23 | 青岛蓝盛洋医药生物科技有限责任公司 | Pharmaceutical composition for treating solar dermatitis and preparation method of pharmaceutical composition |
| CN105213570A (en) * | 2015-09-29 | 2016-01-06 | 罗奕珺 | A kind of pharmaceutical composition for the treatment of solar dermatitis and preparation method thereof |
| CN105232758A (en) * | 2015-10-10 | 2016-01-13 | 临沂草之美医药科技有限公司 | Solar dermatitis treating pharmaceutical composition and preparation method thereof |
| CN105878560A (en) * | 2015-10-10 | 2016-08-24 | 烟台市蓝洋之草医药生物科技有限公司 | Method for preparing medical composition capable of treating solar dermatitis |
| CN105311427A (en) * | 2015-11-18 | 2016-02-10 | 暨南大学 | Pharmaceutical composition containing folium artemisiae argyi for treating solar dermatitis |
| CN105327032A (en) * | 2015-11-26 | 2016-02-17 | 王辉 | Traditional Chinese medicine composition for treating solar dermatitis, preparation method and use method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105688159A (en) | 2016-06-22 |
| CN103893722B (en) | 2016-06-01 |
| CN105688160A (en) | 2016-06-22 |
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