CN105311427A - Pharmaceutical composition containing folium artemisiae argyi for treating solar dermatitis - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to a pharmaceutical composition containing folium artemisiae argyi for treating solar dermatitis. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 6-12 parts of gastrodia elata, 5-15 parts of folium artemisiae argyi, 8-16 parts of fructus gardeniae, 10-15 parts of dried rehamnnia root, 5-10 parts of chrysanthemum flowers, 6-10 parts of houttuynia cordata, 3-6 parts of mint, 6-12 parts of radix paeoniae rubra, 5-15 parts of fructus forsythiae, 10-20 parts of notopterygium root, 9-15 parts of rhizoma chuanxiong, 5-15 parts of moutan bark, 6-9 parts of schizonepeta, 7-9 parts of pinellia ternata, 4-14 parts of radix sophorae flavescentis, and 5-12 parts of licorice root. The pharmaceutical composition has the efficacies of clearing away heat and toxic materials, treating skin and resisting allergy, dispersing blood stasis and dredging collaterals, diminishing inflammation and relieving itching, as well as clearing damp and eliminating diseases, and also has the advantages of good curative effects, small side effects, small possibility of relapse, and simplicity in popularization and application.

Description

A kind of pharmaceutical composition containing Folium Artemisiae Argyi being used for the treatment of solar dermatitis

Technical field

The invention belongs to the field of Chinese medicines, particularly relate to a kind of pharmaceutical composition containing Folium Artemisiae Argyi being used for the treatment of solar dermatitis.

Background technology

Solarized dermatitis and solar dermatitis, also known as sunburn or sunburn, be a kind of acute inflammatory reaction that normal skin produces after being exposed to the sun, show as erythema, edema, vesicle and pigmentation, desquamation.It is a kind of anaphylaxis dermatoses being caused by light, betide exposure portion.Principle is: normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, and permeability increases.Shine the action spectrum mainly UVB of primary disease in red-letter day spring and summer, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.The action spectrum mainly UVB of primary disease, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.The action spectrum mainly UVB of primary disease, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.The action spectrum mainly UVB of primary disease, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.The action spectrum mainly UVB of primary disease, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.After more than a few hours to ten hour, occur the erythra such as erythema, pimple, welt sample or blister in exposure portion, cutaneous lesion has burn feeling, gargalesthesia or twinge, often affects sleep.Can fully recover in the lighter 2-3 days, severe patient could recover for about one week.Erythema colour-darkening subsequently, desquamation or the pigmentation left in various degree.Few patients can with conjunctival congestion, blepharoedema.The wide person of Exposure to Sunlight area, can cause class cold symptoms, as heating, fear of cold, headache, weak, nauseating and general malaise etc., even cardiopalmus, shock.

The pathogenic factor of solar dermatitis has a lot, is not only to be irradiated by sunlight to cause.Except sunlight irradiates, food, medicine factor also can cause dermatitis.As food or medicines such as Herba Spinaciae, Brassica campestris L Herba Capsellae, Amaranthus mangostanus L., Herba Apii graveolentis, Fructus Solani melongenae, Rhizoma Solani tuber osi, Flos Chrysanthemi, the Radixs Angelicae Dahuricae.After edible, the photosensitive material inside these foods, medicine will be put aside in vivo, and when reaching finite concentration, the skin of face, human body exposed position, hands, foot can cause dysbolismus through the direct projection of sunlight and bring out dermatitis.Some chemical & blended fabric, absorbing sweat permeability is poor, and the weak medicated clothing of reflection action also easily causes solar dermatitis.In addition, body constitution is also a very important factor.Chinese medicine think primary disease due to natural endowment not resistance to, raw in heat in blood, feed stimulating food, taste are lacked of proper care, damp and hot interior life, and multiple because of Exposure to Sunlight, pyretic toxicity attacks skin, sends out suddenly.Generally speaking, the white and xerodermatic people of skin than oily skin and the black people of skin more responsive to daylight.

If the drug main Western medicine of current treatment solar dermatitis, the lighter's antihistaminic, severe one or curative effect not good enough person's low-dose Oral glucocorticoid, aspirin or indomethacin.But these medicines are mostly hormone medicine, life-time service, not only certain damage is caused to skin or other organ, and can not from the skin quality of radical change to sun sensitivity.In addition, there is a small amount of Chinese medicine composition for the treatment of solar dermatitis, reaching therapeutic effect in varying degrees, but unsatisfactory.

China applies for a patent 201410113112.8 and discloses a kind of Chinese medicine composition for the treatment of solar dermatitis, this Chinese medicine composition is prepared from by the raw material of following weight portion: Herba Portulacae 10-50 part, Rhizoma Et Radix Notopterygii 10-20 part, Flos Sophorae 5-20 part, Radix Scutellariae 5-15 part, Radix Rehmanniae Preparata 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Herba Taraxaci 1-10 part, Fructus Lycii 5-15 part, Herba Scutellariae Barbatae 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, berberine 0.2-9 part, Radix Paeoniae Alba 5.5-15 part, Rhizoma Zingiberis 6-9 part, Radix Glycyrrhizae 10-15 part, this Chinese medicine composition has anti-inflammatory and antalgic, effect of activating blood circulation to dissipate blood stasis, but can not prevention and therapy solar dermatitis comprehensively.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of pharmaceutical composition containing Folium Artemisiae Argyi being used for the treatment of solar dermatitis, this pharmaceutical composition has heat-clearing and toxic substances removing, treats skin antiallergic, disperse blood stasis and dredge collateral, anti-inflammatory anti-itch, damp eliminating is except effect of fraud, also have good effect, side effect low, not easily recur and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.

Pharmaceutical composition of the present invention is prepared from by the raw material of following parts by weight:

Rhizoma Gastrodiae 6-12 part, Folium Artemisiae Argyi 5-15 part, Fructus Gardeniae 8-16 part, Radix Rehmanniae 10-15 part, Flos Chrysanthemi 5-10 part, Herba Houttuyniae 6-10 part, Herba Menthae 3-6 part, Radix Paeoniae Rubra 6-12 part, Fructus Forsythiae 5-15 part, Rhizoma Et Radix Notopterygii 10-20 part, Rhizoma Chuanxiong 9-15 part, Cortex Moutan 5-15 part, Herba Schizonepetae 6-9 part, Rhizoma Pinelliae 7-9 part, Radix Sophorae Flavescentis 4-14 part and Radix Glycyrrhizae 5-12 part.

Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

6 parts, Rhizoma Gastrodiae, Folium Artemisiae Argyi 5 parts, Fructus Gardeniae 8 parts, Radix Rehmanniae 10 parts, Flos Chrysanthemi 5 parts, Herba Houttuyniae 6 parts, Herba Menthae 3 parts, Radix Paeoniae Rubra 6 parts, Fructus Forsythiae 5 parts, Rhizoma Et Radix Notopterygii 10 parts, Rhizoma Chuanxiong 9 parts, Cortex Moutan 5 parts, Herba Schizonepetae 6 parts, the Rhizoma Pinelliae 7 parts, Radix Sophorae Flavescentis 4 parts and 5 parts, Radix Glycyrrhizae.

Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

12 parts, Rhizoma Gastrodiae, Folium Artemisiae Argyi 15 parts, Fructus Gardeniae 16 parts, Radix Rehmanniae 15 parts, Flos Chrysanthemi 10 parts, Herba Houttuyniae 10 parts, Herba Menthae 6 parts, Radix Paeoniae Rubra 12 parts, Fructus Forsythiae 15 parts, Rhizoma Et Radix Notopterygii 20 parts, Rhizoma Chuanxiong 15 parts, Cortex Moutan 15 parts, Herba Schizonepetae 9 parts, the Rhizoma Pinelliae 9 parts, Radix Sophorae Flavescentis 14 parts and 12 parts, Radix Glycyrrhizae.

Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

10 parts, Rhizoma Gastrodiae, Folium Artemisiae Argyi 12 parts, Fructus Gardeniae 12 parts, Radix Rehmanniae 11 parts, Flos Chrysanthemi 6 parts, Herba Houttuyniae 8 parts, Herba Menthae 4 parts, Radix Paeoniae Rubra 10 parts, Fructus Forsythiae 13 parts, Rhizoma Et Radix Notopterygii 15 parts, Rhizoma Chuanxiong 12 parts, Cortex Moutan 10 parts, Herba Schizonepetae 7 parts, the Rhizoma Pinelliae 8 parts, Radix Sophorae Flavescentis 10 parts and 10 parts, Radix Glycyrrhizae.

Further, described pharmaceutical composition is made into gel ointment, spray or powder.

Accordingly, the preparation method of described pharmaceutical composition comprises following step:

S1 gets Rhizoma Gastrodiae and cleans, crushed after being dried, cross 80-100 mesh sieve, adding Rhizoma Gastrodiae coarse powder weight 5-8 times amount volume fraction is the ethanol of 75-80%, soak 10-12 hour, supersound extraction twice at 55-65 DEG C, each 40-50 minute, supersonic frequency is 25-35kHz, filter, merging filtrate, during filtrate reduced in volume to 55 DEG C, relative density is the clear paste of 1.10-1.20, Rhizoma Gastrodiae extract processed;

S2 gets Folium Artemisiae Argyi, Fructus Gardeniae, Radix Rehmanniae, Flos Chrysanthemi, Herba Houttuyniae, Herba Menthae, Radix Paeoniae Rubra, Fructus Forsythiae, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Cortex Moutan, Herba Schizonepetae, the Rhizoma Pinelliae, Radix Sophorae Flavescentis and Radix Glycyrrhizae, above-mentioned Chinese crude drug is pulverized, adding above-mentioned coarse powder gross weight 7-9 times concentration is the alcoholic solution of 65-75%, reflux, extract, 2-4 time, each 3-5h, filters, decompression filtrate recycling ethanol, cold filtration, washes with water, obtains Chinese medical concrete;

The Chinese medical concrete that the Rhizoma Gastrodiae extract that step S1 obtains by S3 and step S2 obtain mixes, and dry, pulverize powdered, can obtain pharmaceutical composition of the present invention.

Source, the nature and flavor of the present invention's component used, return through and effect:

Rhizoma Gastrodiae: Rhizoma Gastrodiae: the dry tuber of the orchid family Gastrodia plant Rhizoma Gastrodiae, taste taste, sweet, property is put down, and returns Liver Channel; Endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral.

Folium Artemisiae Argyi: be the dried leaves of feverfew Chinese mugwort; Its taste acrid, bitter, warm, returns liver,spleen,kidney warp; Folium Artemisiae Argyi has the effects such as warming the meridian for stopping bleeding, dispersing cold for relieving pain, regulating menstruation are antiabortive, removing damp to relieve itching, dredge the meridian passage.

Fructus Gardeniae: this product is the fruit of Maguireothamnus speciosus Fructus Gardeniae; Bitter in the mouth, cold in nature; GUIXIN, lung, tri-jiao channel; Clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain.

Radix Rehmanniae: this product is the rhizome for scrophulariaceae rehmannia glutinosa plant; Sweet-bitter flavor, cold in nature; GUIXIN, liver, kidney channel; Heat clearing away, removing heat from blood, promotes the production of body fluid.

Flos Chrysanthemi: this product is the dry capitulum of feverfew chrysanthemum; Sweet-bitter flavor, cold nature; Return lung, Liver Channel; Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.

Herba Houttuyniae: this product is the dry aerial parts for saururaceae plant houttuynia cordata; Acrid in the mouth, tepor; Enter liver, lung two warp; Heat-clearing and toxic substances removing, inducing diuresis to remove edema.

Herba Menthae: this product is the dry aerial parts of Labiatae mint Herba Menthae; Acrid in the mouth, cool in nature; Return lung, Liver Channel;

Dispelling wind-heat, refresh oneself, rash.

Radix Paeoniae Rubra: this product is the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra; Bitter in the mouth, cold nature; Return Liver Channel; Clearing away heat and cooling blood, eliminating stasis to stop pain.

Fructus Forsythiae: this product is Oleaceae forsythia; Hardship, cool; Enter the heart, liver, gallbladder meridian; Heat clearing away, removing toxic substances, eliminating stagnation, detumescence.

Rhizoma Et Radix Notopterygii: this product is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii (back of the body wing celery) or Radix et Rhizoma Notopterygii; Acrid in the mouth, hardship, warm in nature; Return bladder, kidney channel; Cold expelling, dispels the wind, dehumidifying, pain relieving.

Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.

Cortex Moutan: this product is for being the dry root bark of ranunculaceae peony; Bitter, pungent, be slightly cold, GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis, reducing the asthenic fever.

Herba Schizonepetae: this product is the dry aerial parts of labiate Herba Schizonepetae; Acrid in the mouth, slightly warm in nature; Return lung, Liver Channel; Induce sweat loose wind, rash.

The Rhizoma Pinelliae: this product is the tuber of the Araeceae Rhizoma Pinelliae; Acrid in the mouth is flat; Enter liver, spleen, lung three warp; Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.

Radix Sophorae Flavescentis: this product is the dry root of leguminous plant Radix Sophorae Flavescentis; Bitter in the mouth, cold in nature; GUIXIN, liver, stomach, large intestine, urinary bladder channel; Heat clearing and damp drying, parasite killing, diuresis.

Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

Compared with prior art, the present invention has following technical advantage:

1, pharmaceutical composition of the present invention is compared with the medicine of other treatment solar dermatitis, at heat-clearing and toxic substances removing, treats skin antiallergic, disperse blood stasis and dredge collateral, anti-inflammatory anti-itch, damp eliminating except in fraud, has more significant effect.

2, compared with the chemotherapeutic agent of Current therapeutic solar dermatitis, pharmaceutical composition of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and pharmaceutical composition effect of the present invention is comprehensive, and medication effect is better.

3, pharmaceutical composition of the present invention also has that compatibility science, preparation technology are simple, good effect, side effect are low, not easily recur and be easy to advantages such as applying.

Detailed description of the invention

It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.

embodiment 1:

The embodiment of the present invention 1 pharmaceutical composition is prepared from by the raw material of following parts by weight: 6 parts, Rhizoma Gastrodiae, Folium Artemisiae Argyi 5 parts, Fructus Gardeniae 8 parts, Radix Rehmanniae 10 parts, Flos Chrysanthemi 5 parts, Herba Houttuyniae 6 parts, Herba Menthae 3 parts, Radix Paeoniae Rubra 6 parts, Fructus Forsythiae 5 parts, Rhizoma Et Radix Notopterygii 10 parts, Rhizoma Chuanxiong 9 parts, Cortex Moutan 5 parts, Herba Schizonepetae 6 parts, the Rhizoma Pinelliae 7 parts, Radix Sophorae Flavescentis 4 parts and 5 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1 gets Rhizoma Gastrodiae and cleans, crushed after being dried, cross 80 mesh sieves, adding Rhizoma Gastrodiae coarse powder weight 5 times amount volume fraction is the ethanol of 75%, soak 10 hours, supersound extraction twice at 55 DEG C, each 40 minutes, supersonic frequency was 25kHz, filter, merging filtrate, during filtrate reduced in volume to 55 DEG C, relative density is the clear paste of 1.10, obtains Rhizoma Gastrodiae extract;

S2 gets Folium Artemisiae Argyi, Fructus Gardeniae, Radix Rehmanniae, Flos Chrysanthemi, Herba Houttuyniae, Herba Menthae, Radix Paeoniae Rubra, Fructus Forsythiae, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Cortex Moutan, Herba Schizonepetae, the Rhizoma Pinelliae, Radix Sophorae Flavescentis and Radix Glycyrrhizae, above-mentioned Chinese crude drug is pulverized, adding above-mentioned coarse powder gross weight 7 times of concentration is the alcoholic solution of 65%, reflux, extract, 2 times, each 3h, filters, decompression filtrate recycling ethanol, cold filtration, washes with water, obtains Chinese medical concrete;

The Chinese medical concrete that the Rhizoma Gastrodiae extract that step S1 obtains by S3 and step S2 obtain mixes, and dry, pulverize powdered, adds corresponding adjuvant, makes gel ointment.

embodiment 2:

The embodiment of the present invention 2 pharmaceutical composition is prepared from by the raw material of following parts by weight: 12 parts, Rhizoma Gastrodiae, Folium Artemisiae Argyi 15 parts, Fructus Gardeniae 16 parts, Radix Rehmanniae 15 parts, Flos Chrysanthemi 10 parts, Herba Houttuyniae 10 parts, Herba Menthae 6 parts, Radix Paeoniae Rubra 12 parts, Fructus Forsythiae 15 parts, Rhizoma Et Radix Notopterygii 20 parts, Rhizoma Chuanxiong 15 parts, Cortex Moutan 15 parts, Herba Schizonepetae 9 parts, the Rhizoma Pinelliae 9 parts, Radix Sophorae Flavescentis 14 parts and 12 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1 gets Rhizoma Gastrodiae and cleans, crushed after being dried, cross 100 mesh sieves, adding Rhizoma Gastrodiae coarse powder weight 6 times amount volume fraction is the ethanol of 80%, soak 11 hours, supersound extraction twice at 60 DEG C, each 45 minutes, supersonic frequency was 30kHz, filter, merging filtrate, during filtrate reduced in volume to 55 DEG C, relative density is the clear paste of 1.15, obtains Rhizoma Gastrodiae extract;

S2 gets Folium Artemisiae Argyi, Fructus Gardeniae, Radix Rehmanniae, Flos Chrysanthemi, Herba Houttuyniae, Herba Menthae, Radix Paeoniae Rubra, Fructus Forsythiae, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Cortex Moutan, Herba Schizonepetae, the Rhizoma Pinelliae, Radix Sophorae Flavescentis and Radix Glycyrrhizae, above-mentioned Chinese crude drug is pulverized, adding above-mentioned coarse powder gross weight 8 times of concentration is the alcoholic solution of 70%, reflux, extract, 3 times, each 4h, filters, decompression filtrate recycling ethanol, cold filtration, washes with water, obtains Chinese medical concrete;

The Chinese medical concrete that the Rhizoma Gastrodiae extract that step S1 obtains by S3 and step S2 obtain mixes, and dry, pulverize powdered, adds corresponding adjuvant, makes spray.

embodiment 3:

The embodiment of the present invention 3 pharmaceutical composition is prepared from by the raw material of following parts by weight: 10 parts, Rhizoma Gastrodiae, Folium Artemisiae Argyi 12 parts, Fructus Gardeniae 12 parts, Radix Rehmanniae 11 parts, Flos Chrysanthemi 6 parts, Herba Houttuyniae 8 parts, Herba Menthae 4 parts, Radix Paeoniae Rubra 10 parts, Fructus Forsythiae 13 parts, Rhizoma Et Radix Notopterygii 15 parts, Rhizoma Chuanxiong 12 parts, Cortex Moutan 10 parts, Herba Schizonepetae 7 parts, the Rhizoma Pinelliae 8 parts, Radix Sophorae Flavescentis 10 parts and 10 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1 gets Rhizoma Gastrodiae and cleans, crushed after being dried, cross 100 mesh sieves, adding Rhizoma Gastrodiae coarse powder weight 8 times amount volume fraction is the ethanol of 80%, soak 12 hours, supersound extraction twice at 65 DEG C, each 50 minutes, supersonic frequency was 35kHz, filter, merging filtrate, during filtrate reduced in volume to 55 DEG C, relative density is the clear paste of 1.20, obtains Rhizoma Gastrodiae extract;

S2 gets Folium Artemisiae Argyi, Fructus Gardeniae, Radix Rehmanniae, Flos Chrysanthemi, Herba Houttuyniae, Herba Menthae, Radix Paeoniae Rubra, Fructus Forsythiae, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Cortex Moutan, Herba Schizonepetae, the Rhizoma Pinelliae, Radix Sophorae Flavescentis and Radix Glycyrrhizae, above-mentioned Chinese crude drug is pulverized, the 9 times of concentration adding above-mentioned coarse powder gross weight are the alcoholic solution of 75%, reflux, extract, 4 times, each 5h, filters, decompression filtrate recycling ethanol, cold filtration, washes with water, obtains Chinese medical concrete;

The Chinese medical concrete that the Rhizoma Gastrodiae extract that step S1 obtains by S3 and step S2 obtain mixes, and dry, pulverize powdered, adds corresponding adjuvant, makes powder.

pharmaceutical composition of the present invention is on the impact of the ear swelling that ultraviolet causes

1, experimental animal: Healthy female SD rat, body weight 0.22kg-0.3kg, is provided by Zhongshan University's animal experimental center; Rat freely absorbs conventional feed and tap water, and raising room temperature is 18 DEG C-25 DEG C.

2, trial drug: gel ointment prepared by the embodiment of the present invention 1.

The object of this test is whether the effect resisting solar dermatitis in order to study Chinese medicine composition of the present invention is better than other drug.Use uviol lamp to mice Continuous irradiation, object is the sunshine environment of simulation mice.When mice causes suffering from solar dermatitis because being exposed to continuously in uviol lamp environment, one of its performance is mice ear inflammation.The left ear be exposed under uviol lamp and the auris dextra be blocked are carried out contrast of weighing, calculates ear swelling value.Contrast the antiinflammation that the ear swelling value of smearing the mice of different pharmaceutical can draw different pharmaceutical, ear swelling value is less, and the curative effect of medicine is better.

3, test method

Get SD rat 36, be divided into 3 groups at random, often organize 12, be respectively blank group, the yellow happy ointment of skin of ice and treatment group.The gel ointment that treatment group uses embodiment 1 to prepare, positive controls is the yellow happy ointment of the skin (Tibet Zhizhi Pharmacy Group Co., Ltd., the accurate word Z10980140 of traditional Chinese medicines) of ice; Be horizontally fixed on by mice on brandreth, with uviol lamp (40WUVA fluorescent tube 3, UVB fluorescent tube 1 vertical dimension 10cm), irradiate 2 weeks, every day, Continuous irradiation 6h, covered animal head and auris dextra with cardboard between the light period.Except blank group, all the other respectively organize and quantitatively use Relative drug to smear mice left ear every day.Irradiation 40h, cuts the left ear of mice respectively and auris dextra is weighed, and calculates ear swelling value (mg).Swelling value=left ear weight-auris dextra weight.

4, result of the test

4.1, general status is observed: after irradiating 3d, serious large redness, desquamation appear in the irradiated left ear skin of blank group mice; Present composition mouse ear skin injury situation is comparatively light, and desquamation phenomenon is less, and the mouse ear skin injury situation of the yellow skin of ice happy ointment group is more serious than present composition mice.Irradiate after 14d, the mouse ear skin injury of the happy ointment group of the yellow skin of ice is serious, and the irradiated left ear skin of mice presents lamellar erythema, festers, vesicle, thicken, tarnish and elasticity, obviously aging; Present composition group mouse ear skin symptom is obviously lighter than positive controls, and erythema is few, ulceration is light, vesicle quantity is few, pachyderma is not obvious.

4.2, anaphylaxis level index:

pharmaceutical composition of the present invention is on the impact of ultraviolet induced mice ear swelling

Group	Ear swelling value (mg)
		Blank group	12.84±4.16
The happy ointment group of the yellow skin of ice	9.15±3.26*
		Treatment group	5.10±3.24**

Note: compare with blank group, * p< 0.05, * * p< 0.01

Result show, compare with blank group, Chinese medicine composition of the present invention can significantly reduce ultraviolet induced mice ear swelling value ( p< 0.01), show that Chinese medicine composition of the present invention has the effect significantly suppressing the mice ear caused by ultraviolet.Under same experiment condition, the happy ointment group of the yellow skin of ice also significantly reduce ear swelling value ( p< 0.05), but its antiphlogistic effects is obviously not as good as Chinese medicine composition of the present invention.Visible, Chinese medicine composition of the present invention has significant curative effect in treatment solar dermatitis.

clinical observation on the therapeutic effect

1, case selection: in 180 routine solar dermatitis disease clinical volunteers patients, man 100 example, female 80 example, at minimum 16 years old of age, maximum 52 years old, all patients all met solar dermatitis symptom, site of pathological change: face, cervical region, two upper limb.

2, exclusion standard:

(1), Complicated with Severe internal medicine disease patient;

(2), drug allergy body constitution patient;

(3), gestation, women breast-feeding their children.

3, criterion of therapeutical effect:

(1) cure: erythra all disappears, red and swollen, pain disappears;

(2) effective: deflorescence is greater than 70%;

(3) effective: deflorescence degree is between 30% to 70%;

(4) invalid: deflorescence is less than 30% or increase the weight of;

(5) total effective rate=(curing number+effective number+efficiently individual quantity)/total number of persons * 100%.

4, instructions of taking: 180 patients are divided into 3 groups at random, often organize 60 people, be respectively treatment A group, treatment B group and treatment C group, use the medicine that the embodiment of the present invention 1,2,3 prepares respectively, external, every day 2-3 time, gets 5g at every turn, continuous use one week.

5, therapeutic outcome:

In 180 routine solar dermatitis patients, cure 160 examples, effective 9 examples, effective 5 examples, invalid 6 examples, cure rate reaches 88.9%, total effective rate is 96.7%; Pharmaceutical composition good effect of the present invention, cure rate is high, can as the drug use for the treatment of solar dermatitis disease.

Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.

Claims (6)

1. be used for the treatment of the pharmaceutical composition containing Folium Artemisiae Argyi of solar dermatitis, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

Rhizoma Gastrodiae 6-12 part, Folium Artemisiae Argyi 5-15 part, Fructus Gardeniae 8-16 part, Radix Rehmanniae 10-15 part, Flos Chrysanthemi 5-10 part, Herba Houttuyniae 6-10 part, Herba Menthae 3-6 part, Radix Paeoniae Rubra 6-12 part, Fructus Forsythiae 5-15 part, Rhizoma Et Radix Notopterygii 10-20 part, Rhizoma Chuanxiong 9-15 part, Cortex Moutan 5-15 part, Herba Schizonepetae 6-9 part, Rhizoma Pinelliae 7-9 part, Radix Sophorae Flavescentis 4-14 part and Radix Glycyrrhizae 5-12 part.

2. be used for the treatment of the pharmaceutical composition containing Folium Artemisiae Argyi of solar dermatitis as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

6 parts, Rhizoma Gastrodiae, Folium Artemisiae Argyi 5 parts, Fructus Gardeniae 8 parts, Radix Rehmanniae 10 parts, Flos Chrysanthemi 5 parts, Herba Houttuyniae 6 parts, Herba Menthae 3 parts, Radix Paeoniae Rubra 6 parts, Fructus Forsythiae 5 parts, Rhizoma Et Radix Notopterygii 10 parts, Rhizoma Chuanxiong 9 parts, Cortex Moutan 5 parts, Herba Schizonepetae 6 parts, the Rhizoma Pinelliae 7 parts, Radix Sophorae Flavescentis 4 parts and 5 parts, Radix Glycyrrhizae.

3. be used for the treatment of the pharmaceutical composition containing Folium Artemisiae Argyi of solar dermatitis as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

12 parts, Rhizoma Gastrodiae, Folium Artemisiae Argyi 15 parts, Fructus Gardeniae 16 parts, Radix Rehmanniae 15 parts, Flos Chrysanthemi 10 parts, Herba Houttuyniae 10 parts, Herba Menthae 6 parts, Radix Paeoniae Rubra 12 parts, Fructus Forsythiae 15 parts, Rhizoma Et Radix Notopterygii 20 parts, Rhizoma Chuanxiong 15 parts, Cortex Moutan 15 parts, Herba Schizonepetae 9 parts, the Rhizoma Pinelliae 9 parts, Radix Sophorae Flavescentis 14 parts and 12 parts, Radix Glycyrrhizae.

4. be used for the treatment of the pharmaceutical composition containing Folium Artemisiae Argyi of solar dermatitis as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

10 parts, Rhizoma Gastrodiae, Folium Artemisiae Argyi 12 parts, Fructus Gardeniae 12 parts, Radix Rehmanniae 11 parts, Flos Chrysanthemi 6 parts, Herba Houttuyniae 8 parts, Herba Menthae 4 parts, Radix Paeoniae Rubra 10 parts, Fructus Forsythiae 13 parts, Rhizoma Et Radix Notopterygii 15 parts, Rhizoma Chuanxiong 12 parts, Cortex Moutan 10 parts, Herba Schizonepetae 7 parts, the Rhizoma Pinelliae 8 parts, Radix Sophorae Flavescentis 10 parts and 10 parts, Radix Glycyrrhizae.

5. be used for the treatment of the pharmaceutical composition containing Folium Artemisiae Argyi of solar dermatitis as claimed in claim 1, it is characterized in that, described pharmaceutical composition is made into gel ointment, spray or powder.

6. the preparation method being used for the treatment of the pharmaceutical composition containing Folium Artemisiae Argyi of solar dermatitis as described in as arbitrary in claim 1-5, it is characterized in that, the preparation method of described pharmaceutical composition comprises following step:

S1 gets Rhizoma Gastrodiae and cleans, crushed after being dried, cross 80-100 mesh sieve, adding Rhizoma Gastrodiae coarse powder weight 5-8 times amount volume fraction is the ethanol of 75-80%, soak 10-12 hour, supersound extraction twice at 55-65 DEG C, each 40-50 minute, supersonic frequency is 25-35kHz, filter, merging filtrate, during filtrate reduced in volume to 55 DEG C, relative density is the clear paste of 1.10-1.20, Rhizoma Gastrodiae extract processed;

S2 gets Folium Artemisiae Argyi, Fructus Gardeniae, Radix Rehmanniae, Flos Chrysanthemi, Herba Houttuyniae, Herba Menthae, Radix Paeoniae Rubra, Fructus Forsythiae, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Cortex Moutan, Herba Schizonepetae, the Rhizoma Pinelliae, Radix Sophorae Flavescentis and Radix Glycyrrhizae, above-mentioned Chinese crude drug is pulverized, adding above-mentioned coarse powder gross weight 7-9 times concentration is the alcoholic solution of 65-75%, reflux, extract, 2-4 time, each 3-5h, filters, decompression filtrate recycling ethanol, cold filtration, washes with water, obtains Chinese medical concrete;

The Chinese medical concrete that the Rhizoma Gastrodiae extract that step S1 obtains by S3 and step S2 obtain mixes, and dry, pulverize powdered, can obtain pharmaceutical composition of the present invention.