CN105287813A - Pharmaceutical composition for treating solar dermatitis and preparing method thereof - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical composition for treating solar dermatitis and a preparing method thereof. The pharmaceutical composition is prepared from, by weight, 10-15 parts of folium ginkgo, 6-10 parts of rhodiola rosea, 2-10 parts of dandelion, 5-9 parts of cortex dictamni, 4-8 parts of pericarpium citri reticulatae, 8-12 parts of roots of common peony, 6-15 parts of honeysuckle, 12-20 parts of notopterygium roots, 8-15 parts of scutellaria baicalensis, 10-15 parts of ligusticum wallichii, 5-9 parts of schizonepeta, 5-9 parts of saposhnicovia divaricata, 5-9 parts of radix sophorae flavescentis, 4-6 parts of periostracum cicada and 5-15 parts of liquorice. The pharmaceutical composition can clear heat for detoxication, protect skin and resist allergy, disperse blood stasis and dredge collaterals, diminish inflammation and relieve itching, and clear damp and remove harmful substances and has the advantages of being good in curative effect, mild in side effect, not prone to reoccurrence, easy to apply and popularize and the like.

Description

A kind of pharmaceutical composition for the treatment of solar dermatitis and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, particularly relate to a kind of pharmaceutical composition for the treatment of solar dermatitis and preparation method thereof.

Background technology

Solar dermatitis is a kind of dermatosis relevant to daylight, namely usually said sunburn.It is a kind of anaphylaxis dermatoses being caused by light, betide exposure portion.Principle is: normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, and permeability increases.Shine the action spectrum mainly UVB of primary disease in red-letter day spring and summer, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.The action spectrum mainly UVB of primary disease, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.The action spectrum mainly UVB of primary disease, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.The action spectrum mainly UVB of primary disease, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.The action spectrum mainly UVB of primary disease, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.After more than a few hours to ten hour, occur the erythra such as erythema, pimple, welt sample or blister in exposure portion, cutaneous lesion has burn feeling, gargalesthesia or twinge, often affects sleep.Can fully recover in the lighter 2-3 days, severe patient could recover for about one week.Erythema colour-darkening subsequently, desquamation or the pigmentation left in various degree.Few patients can with conjunctival congestion, blepharoedema.The wide person of Exposure to Sunlight area, can cause class cold symptoms, as heating, fear of cold, headache, weak, nauseating and general malaise etc., even cardiopalmus, shock.

The pathogenic factor of solar dermatitis has a lot, is not only to be irradiated by sunlight to cause.Except sunlight irradiates, food, medicine factor also can cause dermatitis.As food or medicines such as Herba Spinaciae, Brassica campestris L Herba Capsellae, Amaranthus mangostanus L., Herba Apii graveolentis, Fructus Solani melongenae, Rhizoma Solani tuber osi, Flos Chrysanthemi, the Radixs Angelicae Dahuricae.After edible, the photosensitive material inside these foods, medicine will be put aside in vivo, and when reaching finite concentration, the skin of face, human body exposed position, hands, foot can cause dysbolismus through the direct projection of sunlight and bring out dermatitis.Some chemical & blended fabric, absorbing sweat permeability is poor, and the weak medicated clothing of reflection action also easily causes solar dermatitis.In addition, body constitution is also a very important factor.Chinese medicine think primary disease due to natural endowment not resistance to, raw in heat in blood, feed stimulating food, taste are lacked of proper care, damp and hot interior life, and multiple because of Exposure to Sunlight, pyretic toxicity attacks skin, sends out suddenly.Generally speaking, the white and xerodermatic people of skin than oily skin and the black people of skin more responsive to daylight.

If the drug main Western medicine of current treatment solar dermatitis, the lighter's antihistaminic, severe one or curative effect not good enough person's low-dose Oral glucocorticoid, aspirin or indomethacin.But these medicines are mostly hormone medicine, life-time service, not only certain damage is caused to skin or other organ, and can not from the skin quality of radical change to sun sensitivity.In addition, there is a small amount of Chinese medicine composition for the treatment of solar dermatitis, reaching therapeutic effect in varying degrees, but unsatisfactory.

China applies for a patent 201410113112.8 and discloses a kind of Chinese medicine composition for the treatment of solar dermatitis, this Chinese medicine composition is prepared from by the raw material of following weight portion: Herba Portulacae 10-50 part, Rhizoma Et Radix Notopterygii 10-20 part, Flos Sophorae 5-20 part, Radix Scutellariae 5-15 part, Radix Rehmanniae Preparata 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Herba Taraxaci 1-10 part, Fructus Lycii 5-15 part, Herba Scutellariae Barbatae 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, berberine 0.2-9 part, Radix Paeoniae Alba 5.5-15 part, Rhizoma Zingiberis 6-9 part, Radix Glycyrrhizae 10-15 part, this Chinese medicine composition has anti-inflammatory and antalgic, effect of activating blood circulation to dissipate blood stasis, but can not prevention and therapy solar dermatitis comprehensively.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of pharmaceutical composition for the treatment of solar dermatitis, this pharmaceutical composition has heat-clearing and toxic substances removing, treats skin antiallergic, disperse blood stasis and dredge collateral, anti-inflammatory anti-itch, damp eliminating is except effect of fraud, also have good effect, side effect low, not easily recur and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.

Pharmaceutical composition of the present invention is prepared from by the raw material of following parts by weight:

Folium Ginkgo 10-15 part, Radix Rhodiolae 6-10 part, Herba Taraxaci 2-10 part, Cortex Dictamni 5-9 part, Pericarpium Citri Reticulatae 4-8 part, Radix Paeoniae Rubra 8-12 part, Flos Lonicerae 6-15 part, Rhizoma Et Radix Notopterygii 12-20 part, Radix Scutellariae 8-15 part, Rhizoma Chuanxiong 10-15 part, Herba Schizonepetae 5-9 part, Radix Saposhnikoviae 5-9 part, Radix Sophorae Flavescentis 5-9 part, Periostracum Cicadae 4-6 part and Radix Glycyrrhizae 5-15 part.

Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Ginkgo 10 parts, Radix Rhodiolae 6 parts, Herba Taraxaci 2 parts, Cortex Dictamni 5 parts, Pericarpium Citri Reticulatae 4 parts, Radix Paeoniae Rubra 6 parts, Flos Lonicerae 6 parts, Rhizoma Et Radix Notopterygii 12 parts, Radix Scutellariae 8 parts, Rhizoma Chuanxiong 10 parts, Herba Schizonepetae 5 parts, Radix Saposhnikoviae 5 parts, Radix Sophorae Flavescentis 5 parts, Periostracum Cicadae 4 parts and 5 parts, Radix Glycyrrhizae.

Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Ginkgo 15 parts, Radix Rhodiolae 10 parts, Herba Taraxaci 10 parts, Cortex Dictamni 9 parts, Pericarpium Citri Reticulatae 8 parts, Radix Paeoniae Rubra 12 parts, Flos Lonicerae 15 parts, Rhizoma Et Radix Notopterygii 20 parts, Radix Scutellariae 15 parts, Rhizoma Chuanxiong 15 parts, Herba Schizonepetae 9 parts, Radix Saposhnikoviae 9 parts, Radix Sophorae Flavescentis 9 parts, Periostracum Cicadae 6 parts and 15 parts, Radix Glycyrrhizae.

Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Ginkgo 14 parts, Radix Rhodiolae 8 parts, Herba Taraxaci 8 parts, Cortex Dictamni 7 parts, Pericarpium Citri Reticulatae 6 parts, Radix Paeoniae Rubra 10 parts, Flos Lonicerae 12 parts, Rhizoma Et Radix Notopterygii 16 parts, Radix Scutellariae 12 parts, Rhizoma Chuanxiong 10 parts, Herba Schizonepetae 8 parts, Radix Saposhnikoviae 7 parts, Radix Sophorae Flavescentis 8 parts, Periostracum Cicadae 5 parts and 10 parts, Radix Glycyrrhizae.

Further, described pharmaceutical composition is made into unguentum, spray, suppository or powder.

Accordingly, the preparation method of described pharmaceutical composition comprises following step:

S1: get Folium Ginkgo, Radix Rhodiolae, Herba Taraxaci, Cortex Dictamni, Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Periostracum Cicadae and Radix Glycyrrhizae, wash away impurity, pulverize respectively after drying, crosses 60-80 mesh sieve, for subsequent use;

S2: get Folium Ginkgo coarse powder, be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount 30-45% volume fraction is the ethanol of 60-85%, regulation and control carbon dioxide flow is 15-20L/h, extracting pressure is 15-20MPa, and extraction temperature is 40-60 DEG C, and extraction time is 1.5-2h, decompression separation obtains Folium Ginkgo extract, retains Folium Ginkgo residue;

S3: get Radix Rhodiolae, Herba Taraxaci, Cortex Dictamni, Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Periostracum Cicadae and Radix Glycyrrhizae coarse powder, add the water of coarse powder total amount 10-12 times amount and the cellulase of coarse powder total amount 1%-2.5%, adjustment PH is 4.50-5.0, lixiviate 1-2 hour at 50-65 DEG C, then at 80-95 DEG C of reflux, extract, 1-2 hour, filter, filtrate and described Folium Ginkgo extract merge, and being evaporated to relative density at 60 DEG C after mix homogeneously is the extractum of 1.10-1.25;

S4: mixed with the extractum of S3 gained by described Folium Ginkgo residue, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.

Source, the nature and flavor of the present invention's component used, return through and effect:

Folium Ginkgo: this product is the dried leaves of Ginkgoaceae plant Ginkgo biloba; Sweet, bitter, puckery, flat; GUIXIN, lung meridian; Blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, astringes the lung and relievings asthma, and changes turbid blood fat reducing.

Radix Rhodiolae: this product is the dry Herb of plant Radix Rhodiolae; Cold, sweet, puckery; Lung meridian; Have QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae nourished heart, effect of hemostasis with astringents, dissipating blood stasis for subsidence of swelling.Cure mainly deficiency of vital energy and physically weak, after being ill fear of cold, shortness of breath and fatigue, cough due to lung-heat, spitting of blood, leucorrhea diarrhoea, traumatic injury etc.

Herba Taraxaci: this product is the dry herb of feverfew Herba Taraxaci; Bitter but sweet flavor, cold in nature; Return liver, stomach warp; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.

Cortex Dictamni: this product is the dry root bark of rutaceae shaggy-fruited dittany; Bitter in the mouth, cold in nature; Return spleen, stomach, urinary bladder channel;

Heat clearing and damp drying, removing toxic substances of dispeling the wind.

Pericarpium Citri Reticulatae: this product is the dry mature skin of rutaceae orange and variety thereof, bitter in the mouth, pungent, warm in nature; Return lung, spleen channel, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.

Radix Paeoniae Rubra: this product is the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra; Bitter in the mouth, cold nature; Return Liver Channel; Clearing away heat and cooling blood, eliminating stasis to stop pain.

Flos Lonicerae: this product is dry flower or the first flower opened of band of caprifoliaceae plant; Sweet in the mouth, cold in nature; Return lung, the heart, stomach warp; Heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat wind.

Rhizoma Et Radix Notopterygii: this product is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii (back of the body wing celery) or Radix et Rhizoma Notopterygii; Acrid in the mouth, hardship, warm in nature; Return bladder, kidney channel; Cold expelling, dispels the wind, dehumidifying, pain relieving.

Radix Scutellariae: this product is the dry root of labiate Radix Scutellariae; Bitter in the mouth, cold in nature; Return lung, gallbladder, spleen, large intestine, small intestine meridian; Have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.

Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.

Herba Schizonepetae: this product is the dry aerial parts of labiate Herba Schizonepetae; Acrid in the mouth, slightly warm in nature; Return lung, Liver Channel; Induce sweat loose wind, rash.

Radix Saposhnikoviae: this product is the dry root of umbelliferae Saposhnikovia divaricata; Acrid in the mouth, sweet, warm in nature; Return bladder, liver, spleen channel; Inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.

Radix Sophorae Flavescentis: this product is the dry root of leguminous plant Radix Sophorae Flavescentis; Bitter in the mouth, cold in nature; GUIXIN, liver, stomach, large intestine, urinary bladder channel; Heat clearing and damp drying, parasite killing, diuresis.

Periostracum Cicadae: exuviae shell when this product is the larva emergence of cicada Cryptotympana atrata Fabr.; Sweet in the mouth, cold in nature; Return lung, Liver Channel; Loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.

Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

Compared with prior art, the present invention has following technical advantage:

1, pharmaceutical composition of the present invention is compared with the medicine of other treatment solar dermatitis, at heat-clearing and toxic substances removing, treats skin antiallergic, disperse blood stasis and dredge collateral, anti-inflammatory anti-itch, damp eliminating except in fraud, has more significant effect.

2, compared with the chemotherapeutic agent of Current therapeutic solar dermatitis, pharmaceutical composition of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and pharmaceutical composition effect of the present invention is comprehensive, and medication effect is better.

3, pharmaceutical composition of the present invention also has that compatibility science, preparation technology are simple, good effect, side effect are low, not easily recur and be easy to advantages such as applying.

Detailed description of the invention

It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.

embodiment 1:

The embodiment of the present invention 1 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Ginkgo 10 parts, Radix Rhodiolae 6 parts, Herba Taraxaci 2 parts, Cortex Dictamni 5 parts, Pericarpium Citri Reticulatae 4 parts, Radix Paeoniae Rubra 6 parts, Flos Lonicerae 6 parts, Rhizoma Et Radix Notopterygii 12 parts, Radix Scutellariae 8 parts, Rhizoma Chuanxiong 10 parts, Herba Schizonepetae 5 parts, Radix Saposhnikoviae 5 parts, Radix Sophorae Flavescentis 5 parts, Periostracum Cicadae 4 parts and 5 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1: get Folium Ginkgo, Radix Rhodiolae, Herba Taraxaci, Cortex Dictamni, Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Periostracum Cicadae and Radix Glycyrrhizae, wash away impurity, pulverize respectively after drying, crosses 80 mesh sieves, for subsequent use;

S2: get Folium Ginkgo coarse powder, be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount 30% volume fraction is the ethanol of 60%, regulation and control carbon dioxide flow is 15L/h, extracting pressure is 15MPa, and extraction temperature is 40 DEG C, and extraction time is 2h, decompression separation obtains Folium Ginkgo extract, retains Folium Ginkgo residue;

S3: get Radix Rhodiolae, Herba Taraxaci, Cortex Dictamni, Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Periostracum Cicadae and Radix Glycyrrhizae coarse powder, add the water of coarse powder total amount 10 times amount and the cellulase of coarse powder total amount 1%, PH is regulated to be 4.50, lixiviate 2 hours at 50 DEG C, then 80 DEG C of reflux, extract, 2 hours, filter, filtrate and described Folium Ginkgo extract merge, and being evaporated to relative density at 60 DEG C after mix homogeneously is the extractum of 1.10;

S4: mixed with the extractum of S3 gained by described Folium Ginkgo residue, drying under reduced pressure, pulverizes, and crosses 80 mesh sieves, to obtain final product.

embodiment 2:

The embodiment of the present invention 2 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Ginkgo 15 parts, Radix Rhodiolae 10 parts, Herba Taraxaci 10 parts, Cortex Dictamni 9 parts, Pericarpium Citri Reticulatae 8 parts, Radix Paeoniae Rubra 12 parts, Flos Lonicerae 15 parts, Rhizoma Et Radix Notopterygii 20 parts, Radix Scutellariae 15 parts, Rhizoma Chuanxiong 15 parts, Herba Schizonepetae 9 parts, Radix Saposhnikoviae 9 parts, Radix Sophorae Flavescentis 9 parts, Periostracum Cicadae 6 parts and 15 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1: get Folium Ginkgo, Radix Rhodiolae, Herba Taraxaci, Cortex Dictamni, Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Periostracum Cicadae and Radix Glycyrrhizae, wash away impurity, pulverize respectively after drying, crosses 80 mesh sieves, for subsequent use;

S2: get Folium Ginkgo coarse powder, be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount 45% volume fraction is the ethanol of 85%, regulation and control carbon dioxide flow is 20L/h, extracting pressure is 20MPa, and extraction temperature is 60 DEG C, and extraction time is 1.5h, decompression separation obtains Folium Ginkgo extract, retains Folium Ginkgo residue;

S3: get Radix Rhodiolae, Herba Taraxaci, Cortex Dictamni, Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Periostracum Cicadae and Radix Glycyrrhizae coarse powder, add the water of coarse powder total amount 12 times amount and the cellulase of coarse powder total amount 2.5%, PH is regulated to be 5.0, lixiviate 1 hour at 65 DEG C, then 95 DEG C of reflux, extract, 1 hour, filter, filtrate and described Folium Ginkgo extract merge, and being evaporated to relative density at 60 DEG C after mix homogeneously is the extractum of 1.25;

S4: mixed with the extractum of S3 gained by described Folium Ginkgo residue, drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, to obtain final product.

embodiment 3:

The embodiment of the present invention 3 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Ginkgo 14 parts, Radix Rhodiolae 8 parts, Herba Taraxaci 8 parts, Cortex Dictamni 7 parts, Pericarpium Citri Reticulatae 6 parts, Radix Paeoniae Rubra 10 parts, Flos Lonicerae 12 parts, Rhizoma Et Radix Notopterygii 16 parts, Radix Scutellariae 12 parts, Rhizoma Chuanxiong 10 parts, Herba Schizonepetae 8 parts, Radix Saposhnikoviae 7 parts, Radix Sophorae Flavescentis 8 parts, Periostracum Cicadae 5 parts and 10 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1: get Folium Ginkgo, Radix Rhodiolae, Herba Taraxaci, Cortex Dictamni, Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Periostracum Cicadae and Radix Glycyrrhizae, wash away impurity, pulverize respectively after drying, crosses 80 mesh sieves, for subsequent use;

S2: get Folium Ginkgo coarse powder, be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount 45% volume fraction is the ethanol of 85%, regulation and control carbon dioxide flow is 20L/h, extracting pressure is 20MPa, and extraction temperature is 60 DEG C, and extraction time is 1.5h, decompression separation obtains Folium Ginkgo extract, retains Folium Ginkgo residue;

S3: get Radix Rhodiolae, Herba Taraxaci, Cortex Dictamni, Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Periostracum Cicadae and Radix Glycyrrhizae coarse powder, add the water of coarse powder total amount 12 times amount and the cellulase of coarse powder total amount 2.5%, PH is regulated to be 5.0, lixiviate 1 hour at 65 DEG C, then 95 DEG C of reflux, extract, 1 hour, filter, filtrate and described Folium Ginkgo extract merge, and being evaporated to relative density at 60 DEG C after mix homogeneously is the extractum of 1.25;

S4: mixed with the extractum of S3 gained by described Folium Ginkgo residue, drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, to obtain final product.

pharmaceutical composition of the present invention is on the impact of the ear swelling that ultraviolet causes

One, testing data

1, experimental animal: Healthy female SD rat, body weight 260 ~ 300g, is provided by Zhongshan University's animal experimental center; Rat freely absorbs conventional feed and tap water, and raising room temperature is 18 DEG C-25 DEG C.

2, trial drug: the pharmaceutical composition that the embodiment of the present invention 1 ~ 3 prepares, is diluted with water to pasty state.

The object of this test is whether the effect resisting solar dermatitis in order to study Chinese medicine composition of the present invention is better than other drug.Use uviol lamp to mice Continuous irradiation, object is the sunshine environment of simulation mice.When mice causes suffering from solar dermatitis because being exposed to continuously in uviol lamp environment, one of its performance is mice ear inflammation.The left ear be exposed under uviol lamp and the auris dextra be blocked are carried out contrast of weighing, calculates ear swelling value.Contrast the antiinflammation that the ear swelling value of smearing the mice of different pharmaceutical can draw different pharmaceutical, ear swelling value is less, and the curative effect of medicine is better.

Two, test method

Get SD rat 50, be divided into 5 groups at random, often organize 10, be respectively blank group, Chinese medicine A group, Chinese medicine B group, Chinese medicine C group, positive controls.Chinese medicine A group is embodiment 1 pharmaceutical composition; Chinese medicine B group is embodiment 2 pharmaceutical composition; Chinese medicine C group is embodiment 3 pharmaceutical composition; Positive controls is the yellow happy ointment of the skin (Tibet Zhizhi Pharmacy Group Co., Ltd., the accurate word Z10980140 of traditional Chinese medicines) of ice.Be horizontally fixed on by mice on brandreth, with uviol lamp (40WUVA fluorescent tube 3, UVB fluorescent tube 1 vertical dimension 10cm), irradiate 2 weeks, every day, Continuous irradiation 6h, covered animal head and auris dextra with cardboard between the light period.Except blank group, all the other respectively organize and quantitatively use Relative drug to smear mice left ear every day.Irradiation 40h, cuts the left ear of mice respectively and auris dextra is weighed, and calculates ear swelling value (mg).Swelling value=left ear weight-auris dextra weight.

Three, result of the test

1, general status is observed: after irradiating 3d, serious large redness, desquamation appear in the irradiated left ear skin of blank group mice; Present composition mouse ear skin injury situation is comparatively light, and desquamation phenomenon is less, and the mouse ear skin injury situation of the yellow skin of ice happy ointment group is more serious than present composition mice.Irradiate after 14d, the mouse ear skin injury of positive controls is serious, and the irradiated left ear skin of mice presents lamellar erythema, festers, vesicle, thicken, tarnish and elasticity, obviously aging; Present composition group mouse ear skin symptom is obviously lighter than positive controls, and erythema is few, ulceration is light, vesicle quantity is few, pachyderma is not obvious.

2, anaphylaxis level index:

Pharmaceutical composition of the present invention is on the impact of ultraviolet induced mice ear swelling

Note: compare with blank group, * p< 0.05, * * p< 0.01

Result show, compare with blank group, Chinese medicine composition A, B and C group of the present invention all can significantly reduce ultraviolet induced mice ear swelling value ( p< 0.01), show that Chinese medicine composition of the present invention has the effect significantly suppressing the mice ear caused by ultraviolet.Under same experiment condition, positive control drug group also significantly reduce ear swelling value ( p< 0.05), but its antiphlogistic effects is obviously not as good as Chinese medicine composition of the present invention.Visible, Chinese medicine composition of the present invention has significant curative effect in treatment solar dermatitis.

clinical observation on the therapeutic effect

1, case selection: in 100 routine solar dermatitis disease clinical volunteers patients, man 60 example, female 40 example, at minimum 18 years old of age, maximum 49 years old, all patients all met solar dermatitis symptom, site of pathological change: face, cervical region, two upper limb.

2, exclusion standard:

(1), Complicated with Severe internal medicine disease patient;

(2), drug allergy body constitution patient;

(3), gestation, women breast-feeding their children.

3, criterion of therapeutical effect:

(1) cure: erythra all disappears, red and swollen, pain disappears;

(2) effective: deflorescence is greater than 70%;

(3) effective: deflorescence degree is between 30% to 70%;

(4) invalid: deflorescence is less than 30% or increase the weight of;

(5) total effective rate=(curing number+effective number+efficiently individual quantity)/total number of persons * 100%.

4, instructions of taking: 100 patients are divided into 2 groups at random, often organize 50 people, be respectively treatment group and matched group (Bing Huangfule ointment Tibet Zhizhi Pharmacy Group Co., Ltd., the accurate word Z10980140 of traditional Chinese medicines), the unguentum of the pharmaceutical composition that treatment group uses the embodiment of the present invention 3 to prepare, outer painting, every day 2-3 time, get 5g, continuous use one week at every turn.

5, therapeutic outcome:

In the routine solar dermatitis patient for the treatment of group 50, cure 37 examples, effective 10 examples, invalid 3 examples, cure rate reaches 74%, and total effective rate is 94%; Matched group cures 25 examples, effective 15 examples, invalid 10 examples, and cure rate reaches 50%, and total effective rate is 80% visible, and the therapeutic effect of the embodiment of the present invention 3 pharmaceutical composition is excellent, and cure rate is high, can as the drug use for the treatment of solar dermatitis disease.

Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.

Claims (6)

1. treat the pharmaceutical composition of solar dermatitis for one kind, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Ginkgo 10-15 part, Radix Rhodiolae 6-10 part, Herba Taraxaci 2-10 part, Cortex Dictamni 5-9 part, Pericarpium Citri Reticulatae 4-8 part, Radix Paeoniae Rubra 8-12 part, Flos Lonicerae 6-15 part, Rhizoma Et Radix Notopterygii 12-20 part, Radix Scutellariae 8-15 part, Rhizoma Chuanxiong 10-15 part, Herba Schizonepetae 5-9 part, Radix Saposhnikoviae 5-9 part, Radix Sophorae Flavescentis 5-9 part, Periostracum Cicadae 4-6 part and Radix Glycyrrhizae 5-15 part.

2. the pharmaceutical composition for the treatment of solar dermatitis as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Ginkgo 10 parts, Radix Rhodiolae 6 parts, Herba Taraxaci 2 parts, Cortex Dictamni 5 parts, Pericarpium Citri Reticulatae 4 parts, Radix Paeoniae Rubra 6 parts, Flos Lonicerae 6 parts, Rhizoma Et Radix Notopterygii 12 parts, Radix Scutellariae 8 parts, Rhizoma Chuanxiong 10 parts, Herba Schizonepetae 5 parts, Radix Saposhnikoviae 5 parts, Radix Sophorae Flavescentis 5 parts, Periostracum Cicadae 4 parts and 5 parts, Radix Glycyrrhizae.

3. the pharmaceutical composition for the treatment of solar dermatitis as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Ginkgo 15 parts, Radix Rhodiolae 10 parts, Herba Taraxaci 10 parts, Cortex Dictamni 9 parts, Pericarpium Citri Reticulatae 8 parts, Radix Paeoniae Rubra 12 parts, Flos Lonicerae 15 parts, Rhizoma Et Radix Notopterygii 20 parts, Radix Scutellariae 15 parts, Rhizoma Chuanxiong 15 parts, Herba Schizonepetae 9 parts, Radix Saposhnikoviae 9 parts, Radix Sophorae Flavescentis 9 parts, Periostracum Cicadae 6 parts and 15 parts, Radix Glycyrrhizae.

4. the pharmaceutical composition for the treatment of solar dermatitis as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Ginkgo 14 parts, Radix Rhodiolae 8 parts, Herba Taraxaci 8 parts, Cortex Dictamni 7 parts, Pericarpium Citri Reticulatae 6 parts, Radix Paeoniae Rubra 10 parts, Flos Lonicerae 12 parts, Rhizoma Et Radix Notopterygii 16 parts, Radix Scutellariae 12 parts, Rhizoma Chuanxiong 10 parts, Herba Schizonepetae 8 parts, Radix Saposhnikoviae 7 parts, Radix Sophorae Flavescentis 8 parts, Periostracum Cicadae 5 parts and 10 parts, Radix Glycyrrhizae.

5. the pharmaceutical composition of the treatment solar dermatitis as described in as arbitrary in claim 1-4, it is characterized in that, described pharmaceutical composition is made into unguentum, spray, suppository or powder.

6. the preparation method of the pharmaceutical composition of the treatment solar dermatitis as described in as arbitrary in claim 1-4, it is characterized in that, the preparation method of described pharmaceutical composition comprises following step:

S1: get Folium Ginkgo, Radix Rhodiolae, Herba Taraxaci, Cortex Dictamni, Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Periostracum Cicadae and Radix Glycyrrhizae, wash away impurity, pulverize respectively after drying, crosses 60-80 mesh sieve, for subsequent use;

S2: get Folium Ginkgo coarse powder, be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount 30-45% volume fraction is the ethanol of 60-85%, regulation and control carbon dioxide flow is 15-20L/h, extracting pressure is 15-20MPa, and extraction temperature is 40-60 DEG C, and extraction time is 1.5-2h, decompression separation obtains Folium Ginkgo extract, retains Folium Ginkgo residue;

S3: get Radix Rhodiolae, Herba Taraxaci, Cortex Dictamni, Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Periostracum Cicadae and Radix Glycyrrhizae coarse powder, add the water of coarse powder total amount 10-12 times amount and the cellulase of coarse powder total amount 1%-2.5%, adjustment PH is 4.50-5.0, lixiviate 1-2 hour at 50-65 DEG C, then at 80-95 DEG C of reflux, extract, 1-2 hour, filter, filtrate and described Folium Ginkgo extract merge, and being evaporated to relative density at 60 DEG C after mix homogeneously is the extractum of 1.10-1.25;

S4: mixed with the extractum of S3 gained by described Folium Ginkgo residue, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.