CN107661391A - Treat Yao nationality medicine external preparation of the proliferation of mammary gland and preparation method thereof - Google Patents
Treat Yao nationality medicine external preparation of the proliferation of mammary gland and preparation method thereof Download PDFInfo
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- CN107661391A CN107661391A CN201710894510.1A CN201710894510A CN107661391A CN 107661391 A CN107661391 A CN 107661391A CN 201710894510 A CN201710894510 A CN 201710894510A CN 107661391 A CN107661391 A CN 107661391A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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Abstract
The invention discloses a kind of Yao nationality medicine external preparation for treating the proliferation of mammary gland and preparation method thereof, it is made of the raw material of following compositions：Hypericum japonicum, honeysuckle, oldenlandia diffusa, mock-strawberry and Radix Isatidis, above-mentioned raw materials are proportionally matched, crush sterilization, Normal juice externally dressing, former grass meal agent, refined patch and refined paste is made.The present invention has the effect of good to proliferation of mammary gland patient.Resisting hyperplasia of mammary glands Yao nationality medicine medicine for external application of the present invention is easy to operate, safely, have no side effect, by Epidermal administration, drug effect can be made to go directly focus, play dispersing stagnated hepatoqi, the promoting flow of qi and blood circulation, scattered stasis detumescence, remove the rotten and let fresh grow, softening and resolving hard mass, pain is eliminated, is stimulated circulation, make breast tissue qi and blood smooth logical, expand blood vessel, increase latex dust elasticity, the effect of recovery patient health breast.
Description
Technical field
The present invention relates to a kind of external preparation and preparation method thereof, more particularly to the external application system for the treatment of proliferation of mammary gland effect
Agent and preparation method.
Background technology
The proliferation of mammary gland is the most common breast disease of women, and its incidence of disease accounts for the first place of mammary gland disease.The proliferation of mammary gland refers to
Breast epithelium and proliferation of fibrous tissue, the retrogression pathological changes and progressive connective group of breast tissue conduit and newborn leaflet in structure
The growth knitted, its pathogenic factor are lacked of proper care mainly due to endocrine hormone, often with the generation of mastitis, such as long-term proliferation and swelling
Also easily develop into malignant breast carcinomas.The proliferation of mammary gland incidence of disease was in the trend that rises year by year in the last few years, age also increasingly low age
Change, there are about 70%~80% women according to investigations has the different degrees of proliferation of mammary gland, is more common in the women of 25~45 years old.Mammary gland increases
Its raw cardinal symptom is distending pain of the breast, can involve bilateral simultaneously, but laid particular stress on more with side.
Doctor trained in Western medicine goes back the more perfect treatment method of neither one and medicine to this disease, mainly carries out body using hormone medicine
Internal hormone is adjusted or operation is extractd.Long-term Hormone class medicine, can only play analgesic effect, and side effect is big,
If perform an operation, damage surface it is big, cure the symptoms, not the disease, but easily recurrence, patient is difficult to receive.Traditional Chinese medicine is to treat this sick first choice
Medicine, because Chinese medicine has regulation endocrine, tune to fill blood, improvement qi-blood circulating, the special efficacy of softening and resolving hard mass, and persistent,
Treat both principal and secondary aspect of disease, have no side effect and be efficacy consolidation, uneasy to recur.
The traditional Chinese medical science thinks：Stagnation of QI due to depression of the liver, mood internal injury, the stagnation of the circulation of vital energy are not relaxed, qi and blood circumfluence is not freely to cause breast pain and lump
An important factor for.The warp and breast relation of liver kidney two is most close, next to that wantonly two arteries and veins of punching.It is broadly divided into several causes of disease：（1）Hepatic depression
Junction type, the depressed impariment of the liver, newborn network be not smooth.（2）Qi stagnation and blood stasis type, extravasated blood internal resistance, blockage of main and collateral channels.（3）Insufficiency of the spleen type of stagnation of phlegm-damp, it is insufficiency of the spleen
Phlegm hinders newborn network, assembles blocking.（4）The deficiency of yang is trembled with fear stagnant type, stagnant newborn network of trembling with fear.
We pass through literature search, it has been found that in some for oral administration or external applications on treatment treatment proliferation of mammary gland effect
Medicine, such as：
1st, Chinese patent, application number：CN200810049178.X；Applicant：Hu Yongwang；
Summary：The present invention relates to a kind of Chinese medicine for treating the proliferation of mammary gland, the Chinese medicine includes traditional Chinese medicine for oral administration ball and Dressed plaster, wherein
Traditional Chinese medicine for oral administration ball is made up of 23 kinds of Chinese herbal medicines, and Dressed plaster is made up of 32 kinds of Chinese herbal medicines.The Chinese prescription compatibility is proper, passes through this
The plaster of invention and pill for oral administration, can effectively cure the proliferation of mammary gland caused by a variety of causes, and quick, short treating period,
Cure rate is high, expense is few.The Chinese medicine is to mammary gland fibroma, breast cancer, nipple discharge, mastodynia, mastitis, mammary gland deformity and breast
Room depauperation, osteomyelitis, caput femoris necrosis, various sore diseases, scrofula, deviation of the mouth with numbness and paralysis also have the effect of uniqueness.It is wherein interior
Medication ball is made up of the medium-height grass raw material of following parts by weight：Radix Angelicae Sinensis, play both sides of the street, PORIA from Yunnan of China, honeysuckle, Radix Isatidis, rascal, Pu Gong
English, cultivated land, each 10-25 parts of the taste Chinese medicine of pangolin 9, frankincense, myrrh, the radix paeoniae rubrathe, baked ginger, rhizoma atractylodis macrocephalae, cornu cerve degelatinatum, the taste of root tuber of aromatic turmeric 7
Each 5-15 parts of Chinese medicine, dried orange peel, peach kernel, Snakegourd Fruit, each 8-20 parts of the taste Chinese medicine of radix scutellariae 4, RADIX ACONITI LATERALIS PREPARATA, the fruit of Chinese magnoliavine, each 2- of taste Chinese medicine of radix glycyrrhizae 3
8；Dressed plaster is made up of the Chinese medicine material of following parts by weight：Root of Chinese clematis 20-40 parts, marihuana 20-40 parts, dung beetle 20-40
Part, leaf of Broussonetia papyrifera(L.) Vent 20-40 parts, yellow wormwood artemisia 20-40 parts, asafoetide 20-40 parts, mulberry tree branch 20-40 parts, honeycomb 20-40 parts, bletilla 20-40
Part, HERBA EPIMEDII 20-40 parts, rhizoma typhonii 20-40 parts, Radix Aconiti 20-40 parts, Radix Aconiti Kusnezoffii 20-40 parts, centipede 50-70 parts, long-noded pit viper
50-70 parts, gecko 50-70 parts, Semen Strychni 50-70 parts, pseudo-ginseng 50-70 parts, mud eel blood 50-70 parts, Impatientis 50-70 parts,
Dried venom of toads 50-70 parts, spina gleditsiae 25-60 parts, verdigris 15-35 parts, Chinese violet 15-35 parts, castor bean 15-35 parts, semen momordicae 15-
35 parts, root of Dahurain angelica 10-25 parts, cassia twig 10-25 parts, Chinese blister beetle 5-15 parts, borneol 10-30 parts, sesame oil 2500-6000 parts, yellow lead 800-
1600 parts.
2nd, Chinese patent, application number：CN201610801265.0 ；Applicant：Zhang Conge；
Summary：The proliferation of mammary gland and the external traditional Chinese medicinal application of adenofibroma of breast are treated the invention discloses a kind of.The medicament with the bletilla striata,
The root of Dahurain angelica, the root of herbaceous peony, radix ampelopsis, the larva of a silkworm with batrytis, Hedyotidis Diffusae, the Chinese bulbul, berry-bearing campion root, ajuga decumbens, vesper iris herb, earthworm are raw material,
External traditional Chinese medicinal application is made.The present invention thinks that human body skin space between skin and muscles connects with vital organs of the human body true strength based on the traditional Chinese medical science, and medicine can lead to
Cross body surface, space between skin and muscles reaches internal organs, play a part of adjusting body, disease-resistant get rid of evils.Inventor is for the proliferation of mammary gland, mammary gland fiber
Specific disease caused by knurl, breast tubercle, swollen breasts etc. is because with reference to long-term clinical practice experience, Park Exquisite Article, invention research and development
This prescription, is affixed on affected part, the property of medicine is entered its space between skin and muscles from pore, stimulates the menstrual flow and passes through network, or heat toxin carries it, or stagnant attack of the stasis of blood and dissipate it,
It is particularly strong than taking medicine.Through clinical test, this is treated, and hard person is easily soft, and knot person is fugitive, and coefficient of stabilization at a specified future date is high, and uneasy to recur,
Eradicate evident in efficacy, this is to the wonderful method of female breast disease.
3rd, Chinese patent, application number：CN201310676403.3；Applicant：Wang Fen；
Summary：The invention discloses a kind of external application Chinese medicine washing lotion for treating the proliferation of mammary gland, belongs to technical field of traditional Chinese medicines.It is by following
The raw material of weight is made：15 grams of Chinese juniper beach wormwood, 15 grams of golden cypress, 15 grams of selfheal, 15 grams of oldenlandia diffusa, 10 grams of rascal, 10 grams of myrrh,
15 grams of kelp, 10 grams of fritillaria thunbergii, 10 grams of Rhizoma Sparganii, 10 grams of radix bupleuri, 10 grams of safflower, 10 grams of earthworm, 10 grams of frankincense, 10 grams of rheum officinale are fragrant
Attached 10 grams, 5 grams of borneol.The present invention is directly administered by external application affected part, is promoted breast local blood circulation unimpeded, can be played and stimulate the menstrual flow
It is active, activate blood circulation and disperse blood clots, swelling and pain relieving, clearing heat and detoxicating effect, diminish inflammation rapidly, swelling and pain relieving, softening absorb lump hyperplasia
Tissue, reach the purpose for fundamentally curing the proliferation of mammary gland.
More than for oral administration or external application Chinese medicine of the treatment proliferation of mammary gland also have the effect for the treatment of proliferation of mammary gland, but basis and this
Invention is different, therefore also has difference in therapeutic effect, the method for medication.
The content of the invention
The purpose of the present invention is to provide a kind of Yao nationality medicine external preparation different from existing external application Chinese medicine to market, can treat breast
Gland hyperplasia, there is regulation endocrine, adjust and fill blood, improve qi-blood circulating, the effect of softening and resolving hard mass, suitable for proliferation of mammary gland crowd
Use.
To achieve these goals, the technical scheme is that：
The Yao nationality medicine external preparation of the proliferation of mammary gland is treated, is made by the herbal raw material of following weight proportion：Hypericum japonicum 3-5 parts；Gold
Honeysuckle flower 3-5 parts；Oldenlandia diffusa 11-13 parts；Mock-strawberry 1-3 parts；Radix Isatidis 1-3 parts.
The present invention preparation method be：
Treat the preparation method of the Yao nationality medicine externally dressing of the proliferation of mammary gland：
Fresh hypericum japonicum, honeysuckle, oldenlandia diffusa, mock-strawberry and Radix Isatidis are taken by weight ratio, are screened impurity, cleaning, are dried in the air
Solid carbon dioxide, paste is broken into using beater after mixing, high temperature sterilization sterilization, vacuum compression is packed after cooling, stand-by.
Treat the preparation method of the Yao nationality medicine externally-applied powder of the proliferation of mammary gland：
Take fresh hypericum japonicum, honeysuckle, oldenlandia diffusa, mock-strawberry and Radix Isatidis by weight ratio, and by raw material stoving, crush
Mixing, 100 mesh sieves are crossed, obtained Chinese medicine powder uses microwave and ultraviolet radiation for sterilizing and disinfecting, packs standby.
Treat the Yao nationality medicine external use plaster preparation method of the proliferation of mammary gland：
Hypericum japonicum, honeysuckle, oldenlandia diffusa, mock-strawberry and Radix Isatidis are taken by weight ratio, and raw material is pulverized and mixed, and are placed in micro-
Ripple drier is dried and sterilized；Raw material adds 10-15 times of water heating to boil 1-2 hours, filters, the dregs of a decoction add 5-10 times again
Amount water is boiled 0.5-1 hours again, filters, and decoction is combined and concentrated into the concentrate that 60 DEG C of relative densities are 1.2-1.25, cold
But, filtrate A is retained；The filtering gained dregs of a decoction add 3-6 times of 95% ethanol measured, and 4-8 DEG C of standing 6-48 hour, mistake are put in after stirring
Filter, refiltered after filtrate is put into the cooling of heating recovery ethanol obtains in ethanol recycling can decoction, and be concentrated into 60 DEG C it is relatively close
The concentrate for 1.2-1.25 is spent, retains liquor B；Filtrate A and liquor B are mixed, then medicine liquid heating is concentrated into paste, then is added
Enter transdermal promotion absorbent stirring, pressure sensitive adhesive, produce external use plaster.
Treat the Yao nationality medicine externally used paste preparation method of the proliferation of mammary gland：
Hypericum japonicum, honeysuckle, oldenlandia diffusa, mock-strawberry and Radix Isatidis are taken by weight ratio, and raw material is pulverized and mixed, and are placed in micro-
Ripple drier is dried and sterilized；Raw material adds 10-15 times of water heating to boil 1-2 hours, filters, the dregs of a decoction add 5-10 times again
Amount water is boiled 0.5-1 hours again, filters, and decoction is combined and concentrated into the concentrate that 60 DEG C of relative densities are 1.2-1.25, cold
But, filtrate A is retained；The filtering gained dregs of a decoction add 3-6 times of 95% ethanol measured, and 4-8 DEG C of standing 6-48 hour, mistake are put in after stirring
Filter, refiltered after filtrate is put into the cooling of heating recovery ethanol obtains in ethanol recycling can decoction, and be concentrated into 60 DEG C it is relatively close
The concentrate for 1.2-1.25 is spent, retains liquor B；Filtrate A and liquor B are mixed, then medicine liquid heating is concentrated into paste, is added
Transdermal promotion absorbent, medical ventolin stir, and produce externally used paste.
Medically research shows that the herbal component selected by the present invention has following effect：
Above-described hypericum japonicum, it is the herb of Garcinia maingayii hypericum japonicum,【Classification system】Herba Hyperici
Japonici,【Alias】：Hypericum japonicum, ringdove nest, tongue of sparrow grass, snake look into mouth, lateral-flower milkwort herb, drop grass, seven cun of gold, perfume (or spice), a Jin Suo
Spoon, the red kid, bigflower clinopodium herb, Tian Bianju, measles grass, light is careless, big shell is careless, the small seed of cowherb, spire Huang, Alocasia amazonica, half-capitate hemiboea herb,
Seven layers of tower, windproof, the small Samson St Johswort of soil, slimyhair sida leaf or root, standing grain rosy clouds gas, scutllaria indica, small hypericum japonicum, it is small revive after death, honey ant medicine, small hancock swallowwort herb,
The thin grass of eight Buddha's warrior attendants grass, snake, hancock swallowwort herb,【Meridian distribution of property and flavor】：Sweet, bitter, cold.Return liver, the spleen channel,【Major function】：The removing toxic substances of feelings liver, promoting the circulation of qi
Xie Yu, promoting blood circulation to remove blood stasis detumescence, clearing heat and promoting diuresis；Clinical medicine has for mastitis in recent years；The results showed：Hypericum japonicum can adjust
Immunologic function, and antitumor action, there is inhibitory action to the cell line of various cancers；Its hypericum japonicum ethanol extract has liver protection
Effect, and have for calm, antidepressant effect.
Above-described honeysuckle, for Caprifoliaceae woodbine honeysuckle and congener dry flower or with just opening
Flower,【Classification system】Lonicera japonica Thunb.,【Alias】：Caulis Lonicerae, silvernine, two dyeing defect rattans, two precious rattans, right-hand rotation
Rattan, sub- wind rattan, mandarin duck rattan, two flowers,【Meridian distribution of property and flavor】：Property is sweet, cold.Attach to the lung and stomach meridians,【Major function】：With clearing heat and detoxicating, anti-
Scorching, qi-restoratives treats the effect of wind, cures mainly disease under turgor, warm disease heating, the disease such as heat toxin large carbuncle and tumour.Its for acute mastitis,
Appendicitis, ulcer boils, erysipelas, parotitis, etc. illness have certain curative effect.Experiment shows, Flos Lonicerae extractive solution have anti-inflammatory and
Antipyretic, booster immunization function effect.
Above-described oldenlandia diffusa, dries all herbal medicine,【Classification system】Herba Hedyotidis
Diffusae,【Alias】：HERBA HEDYOTIS DIFFUSAE, Herba Turczaninowiae Fastigiatae, Radix Picriae felterrae,【Meridian distribution of property and flavor】：Mildly bitter flavor, it is cold in nature.Enter stomach, large intestine, small intestinl channel,
【Major function】：Medicinal powder for relieving pain knot, clearing heat and detoxicating, dampness removing is treating stranguria, anti-inflammatory, cures mainly furuncle sore, cancerous swelling, boil swelling and pain.It can be used for
Treat benign thyroid nodules.Modern medicine experiment proves that oldenlandia diffusa is known as following effect：（1）There are a variety of anti-knurl compositions,
It is a kind of broad-spectrum anti-cancer drug, such as tumour to acute lymphoblastic type, granulocyte type, monocyte type and chronic granulocyte type
Cell has inhibitory action；（2）The immunocompetence of body can be significantly increased, reticuloendothelial cell hyperplasia is such as stimulated, enlivens phagocytosis,
Promote antibody to be formed, and argentophile substance in the tissue such as lymph node, spleen, liver is changed in densification.
Above-described mock-strawberry, it is the herb of rose family mock-strawberry platymiscium mock-strawberry,【Classification system】Duchesnea
Indica (Andr.) Focke,【Alias】：Snake bubble grass, dragon tell pearl, three-jaw wind, nosebleed fruit fruit, pearl pawl, snake fruit, cockscomb fruit, open country
Strawberry, snake Fischer, the certain kind of berries, the silkworm certain kind of berries, 3 points red, lion tail, treats sore medicine, snake egg-fruit, humid euphorbia, three wind, snake bubble grass, three skin wind, three
Pawl is imperial, old She Pao, snake Rong grass, three pin tiger, snakeskin rattan, the valve of snake eight, dragon rank pearl, small strawberry, goodfriday grass, Herba Botrychii, golden cicada grass, three
Leaf Fischer, old snake thorn account for, old snake Basket-for-carrying-soil, Long Qiucao, porcelain ampelopsis, snake fruit rattan, snake pillow, five-fingered jack, She Pancao, heartily fruit, numb snake fruit,
Kowloon grass, three grass, snake mother-in-law, snake tortoise grass, landing red bayberry, red top fruit, blood malignant boil grass, wild strawberry,【Meridian distribution of property and flavor】：It is sweet, bitter, property
It is cold.Enter lung, liver, large intestine channel,【Major function】：It is clearing heat and detoxicating, eliminating stasis to subdue swelling, cooling blood and hemostasis.Cure mainly pyreticosis, frightened epilepsy, flu, dysentery
Disease, jaundice, hot eyes, aphtha, pharyngalgia, mumps, furuncle, venomous snake bite, spit blood, uterine bleeding, irregular menstruation, burn and scald, treating swelling and pain by traumatic injury.
Modern experimental shows that growth of the mock-strawberry the water extracted immersing paste to tumour has obvious inhibitory action.
Above-described Radix Isatidis, it is the dry root of plant woaded blue or careless smalt,【Classification system】Isatis
Tinctoria,【Alias】：It is indigo-blue, indigo root, indigo root, woaded blue, mountain indigo plant, great Lan roots, rhizoma et radix baphicacanthis, Lan Longgen, earth ridge root, big
Indigo,【Meridian distribution of property and flavor】：Hardship, tremble with fear.The thoughts of returning home, stomach,【Major function】：Clearing heat and detoxicating, blood cooling and ecchymoses removing, relieving sore throat and acesodyne, cure mainly warm epidemic disease
When poison, generate heat pharyngalgia, febrile virulent maculae, mumps, scarlet fever, major part pestilence, erysipelas, carbuncle swells.Can it is antiviral, removing toxic substances, improve exempt from
Epidemic disease, antitumor action.
There is the present invention pharmacological function of each composition in the Yao nationality medicine external preparation for treating proliferation of mammary gland effect to be：
The removing toxic substances of hypericum japonicum feelings liver, promoting qi circulation and removing obstruction in the collateral, promoting blood circulation to remove blood stasis detumescence, clearing heat and promoting diuresis, its hypericum japonicum ethanol extract have liver protection work
With, and have for calm, antidepressant effect, it is effective in cure for liver qi stagnation type and the qi stagnation and blood stasis type proliferation of mammary gland；Honeysuckle
Anti-inflammatory detumescence, protect liver, gold and silver flower total saponine that is antitumor, being extracted among honeysuckle play liver-protective effect.For liver
Obstruction of the circulation of vital energy junction type and the qi stagnation and blood stasis type proliferation of mammary gland are effective in cure；Oldenlandia diffusa heat-clearing dissipates the stasis of blood, the carbuncle that disappears removing toxic substances, medicinal powder for relieving pain knot, dampness removing
It is treating stranguria, outstanding kind treatment all kinds inflammation and furuncle sore, cancerous swelling.Its oldenlandia diffusa extracted is known as anticancer and swells and treat good
The effect of property thyroid nodule.Treat mammary gland swelling, mastitis and prevent breast cancer from having unique curative effect；Mock-strawberry heat-clearing solution
Poison, eliminating stasis to subdue swelling, there is inhibitory action to tumour；Radix Isatidis is clearing heat and detoxicating, anti-inflammatory dissipate stasis of blood hemostasis, cures mainly the strongly fragrant lung of phlegm heat, Huang of coughing up phlegm
It is thick, carbuncle swells, there is therapeutic efficiency to various inflammation.It is effective in cure to the qi stagnation and blood stasis type proliferation of mammary gland, while mastitis is also treated, prevent
The generation of breast cancer.
In its prescription, oldenlandia diffusa is monarch drug in a prescription；Honeysuckle, hypericum japonicum are ministerial drug；Folium isatidis, Radix Isatidis are adjutant.
It is exactly Yao nationality medicine externally applied formulation that the present invention has treatment proliferation of mammary gland effect and preparation method thereof above, maximizes guarantor
Stay activating blood circulation and reducing swelling in various raw materials, eliminating stasis to subdue swelling, promoting qi circulation and removing obstruction in the collateral, anti-inflammatory and anticancer, the plurality of Chinese element of medicinal powder for relieving pain knot.It is suitable extensively
Proliferation of mammary gland patient is closed to use.
Beneficial effects of the present invention：
1st, the present invention forms by Yao nationality's ancient prescription is refined, and medicine go directly affected part, reaches treatment mammary gland increasing using Chinese herbal medicine itself effect
Raw purpose, the pain that patient uses hormone and the operative treatment proliferation of mammary gland is avoided, is had no adverse reaction while curing the disease, nothing
Side effect.
2nd, while the proliferation of mammary gland is treated, mastitis has also been treated simultaneously, has more prevented the generation of breast cancer, realizes multiple
The effect for the treatment of and prevention.
3rd, production process does not pollute, and raw material are widely present and cheap, suitable pharmaceutical factory large-scale production needs.
Embodiment
Embodiment 1
Following raw material is taken by weight ratio：4 parts of hypericum japonicum, 4 parts of honeysuckle, 12 parts of oldenlandia diffusa, 2 parts of mock-strawberry；Radix Isatidis 2
Part.Preparation method be：Fresh hypericum japonicum, honeysuckle, oldenlandia diffusa, mock-strawberry and Radix Isatidis are taken by weight ratio, are screened
Impurity, cleaning, dries water, is broken into paste using beater after mixing, high temperature sterilization sterilization, vacuum compression packaging is treated after cooling
With producing externally dressing.Patient before evening sleep by Normal juice externally dressing in use, directly spread on affected part, with preservative film covering medicine
Thing, then with absorbent gauze and immobilization with adhesive tape, it is secondary medicine to be walked clearly, wipes clean skin when rising with the sun.
Embodiment 2
Following raw material is taken by weight ratio：Hypericum japonicum 3-5 parts, honeysuckle 3-5 parts, oldenlandia diffusa 11-13 parts, mock-strawberry 1-3 parts；
Radix Isatidis 1-3 parts.The preparation method of former grass meal agent is：Take by weight ratio fresh hypericum japonicum, honeysuckle, oldenlandia diffusa,
Mock-strawberry, Radix Isatidis, and by raw material stoving, be pulverized and mixed, cross 100 mesh sieves, obtained Chinese medicine powder killed using microwave and ultraviolet
Bacterium sterilizes, and pack is standby, produces pulvis.In use, pulvis is placed in container, addition second rice washing water stirs patient
Into pasty state, external application affected part before sleeping at night, medicine is covered with preservative film, then with absorbent gauze and immobilization with adhesive tape, it is secondary when rising with the sun
Medicine is walked clearly, wipes clean skin.
Embodiment 3
Following raw material is taken by weight ratio：3 parts of hypericum japonicum, 3 parts of honeysuckle, 11 parts of oldenlandia diffusa, 1 part of mock-strawberry, Radix Isatidis 1
Part, and raw material is pulverized and mixed, it is placed in microwave dryer and is dried and sterilizes.Raw material adds 10 times of water heating to boil 1 hour, mistake
Filter, the dregs of a decoction add 5 times of amount water to boil again 0.5 hour, filtered again, and decoction is combined and concentrated into the concentration that 60 DEG C of relative densities are 1.2
Liquid, cooling, retain filtrate A；The filtering gained dregs of a decoction add 95% ethanol of 3 times of amounts, and 4 DEG C are put in after stirring and stands 6 hours, is filtered, will
Filtrate refilters after putting the decoction cooling that heating recovery ethanol obtains in ethanol recycling can, and is concentrated into 60 DEG C of relative densities and is
1.2 concentrate, retain liquor B, filtrate A and liquor B are mixed, then medicine liquid heating is concentrated into paste, add transdermal rush
Enter absorbent stirring, pressure sensitive adhesive, produce patch.Patient is taken off i.e. using finishing in use, refined patch directly is affixed on into affected part
Can, drug residue free is on skin.
Embodiment 4
Following raw material is taken by weight ratio：5 parts of hypericum japonicum, 5 parts of honeysuckle, 13 parts of oldenlandia diffusa, 3 parts of mock-strawberry, Radix Isatidis 3
Part, and raw material is pulverized and mixed, it is placed in microwave dryer and is dried and sterilizes.Raw material adds 15 times of water heating to boil 2 hours, mistake
Filter, the dregs of a decoction add 10 times of amount water to boil again 1 hour, filtered again, and decoction is combined and concentrated into the concentration that 60 DEG C of relative densities are 1.25
Liquid, cooling, retain filtrate A；The second step filtering gained dregs of a decoction add 95% ethanol of 6 times of amounts, and 8 DEG C are put in after stirring and stands 48 hours,
Filtering, refiltered after filtrate is put into the decoction cooling that heating recovery ethanol obtains in ethanol recycling can, and be concentrated into 60 DEG C relatively
Density is 1.25 concentrate, retains liquor B, and filtrate A and liquor B are mixed, then medicine liquid heating is concentrated into paste, is added saturating
Skin promotes absorbent, medical ventolin to stir, and produces paste.Patient is in use, refined paste is smeared fresh-keeping in affected part, use
Film covers medicine, then with absorbent gauze and immobilization with adhesive tape, secondary medicine to be walked clearly, wipes clean skin when rising with the sun.
Application Example：
It is clinical to totally 214 proliferation of mammary gland patient, patient's symptom include breast pain, lobular hyperplasia, mastosis, cystic hyperplasia,
Galactoncus disease, mammary gland fibroma, carry out this precious jade medicine external preparation and treated and be tracked further consultation, the age be 25 years old extremely
The women of 53 years old, the standard for including statistics meet following standard：
Criterion of therapeutical effect：
1st, treatment recovery from illness：The clinical sign and lump of patient's chest pain are wholly absent, and are not recurred in 3 years.
2nd, treatment is effective：Patient's chest pain is obviously improved or disappeared, and lump has reduced.
3rd, treatment is invalid：Patient's chest pain and lump are not improved.
Therapeutic scheme：
After the daily hot water bathing of patient, external preparation is pasted or is applied to affected part, continue 8-12 hour, be used continuously 6 and be
One course for the treatment of, afterwards further consultation are observed once, altogether using 4 courses for the treatment of, obtain following clinical data：
| Before treatment | After treatment | It is efficient | Cure rate |
| Severe（Ⅳ）Galactoncus disease 24 | Invalid 0；Effective 6；Recovery from illness 18 | 100% | 75% |
| Severe（Ⅲ）Cystic hyperplasia of mammary gland 32 | Invalid 0；Effective 4；Recovery from illness 28 | 100% | 87.5% |
| Moderate（Ⅱ）Adenosis of mammary glands, 43 | Invalid 0；Effective 7；Recovery from illness 36 | 100% | 83.7% |
| Slightly（Ⅰ）Hyperplasia of mammary glands 35 | Invalid 0；Effective 5；Recovery from illness 30 | 100% | 85.7% |
| Acute mastitis disease 15 | Invalid 0；Effective 3；Recovery from illness 12 | 100% | 80% |
Clinical test shows：Precious jade medicine external preparation of the present invention is to breast pain, lobular hyperplasia, mastosis, cystic hyperplasia, mammary gland capsule
Swollen disease, mammary gland fibroma have significant curative effect, and effective percentage reaches 100%.
Test examples：
Embodiment 1：River, female, Guiping, Guangxi people, 25 years old, there was a lump in General Office Clerk, the left breast portion on the lower side of readme, usually feels
Feel left breast and periphery pain.It is the left side proliferation of mammary gland to go to hospital diagnosis, is implemented before river is slept at night daily afterwards using the present invention
The externally dressing of example 1 is applied in affected part, is taken off drug paste after being wakeeed up to morning, every night about 9 hours of topical application of drug time altogether, has been used continuously 12
Individual evening.Affected part pain be improved significantly, the swelling sense of lump substantially mitigates.
Embodiment 2：What so-and-so, female, people from Nanning, 38 years old, hotel guest room waiter, the left shoulder neck of readme was often ached, sternly
Left arm can not exert oneself during weight, sense of motion difficulty of raising one's hand, especially particularly evident before menstrual period.It is left breast mammary gland toward hospital diagnosis
Three degree of hyperplasia, and left shoulder neck pain is radiated, two degree of hyperplasia of the right breast.So-and-so sleeps the preceding use embodiment of the present invention 2 daily for what
Apply after pulvis mixing batter in affected part, take drug paste off to after wakeing up, per per day about 10 hours of topical application of drug time, be used continuously 30
Individual evening.Two shoulder neck pain and lump before menstrual period completely without also no longer feeling in great pain.Every going hospital's further consultation after two months,
Left and right Mammary proliferation has been fully recovered.
Embodiment 3：Chen, female, Xiangtan, Hunan Province people, 47 years old, civil servant, the normal distending pain of readme both sides breast, touching was pain.Through
Examination in hospital is both sides breast many places four degree of hyperplasia of mammary gland and fibroma.Chen is applied to using the patch of the embodiment of the present invention 3 daily
Both sides breast affected part, twice daily, about 10 hours every time, after having used 15, both sides swollen breasts disappeared substantially, after change
To be attached to affected part using this medicine for external application before daily sleep, drug paste is taken off to after wakeing up, after continuously having used one month again, goes to cure
Institute is rechecked, and four degree of hyperplasia of diagnosis are wholly absent, and mammary gland fibroma is also obviously reduced.
Embodiment 4：Gold certain, female, people from Liuzhou, 29 years old, representative of sales ＆ marketing, readme both sides breast periodicity swelling pain,
Using right breast as very, persistently one-year age, symptom are increasingly obvious.Increase through examination in hospital for both sides breast many places mammary gland
It is raw.Certain is applied to both sides breast affected part to gold using the paste of the embodiment of the present invention 4, twice daily, after having used one month, both sides
Swollen breasts are relieved.
Claims (5)
1. treat the Yao nationality medicine external preparation of the proliferation of mammary gland, it is characterised in that：It is made by the herbal raw material of following weight proportion：Field
Base Huang 3-5 parts, honeysuckle 3-5 parts, oldenlandia diffusa 11-13 parts, mock-strawberry 1-3 parts, Radix Isatidis 1-3 parts, obtained external used medicine
Preparation is externally dressing, pulvis, patch or paste.
2. the Yao nationality medicine external preparation of the treatment proliferation of mammary gland as claimed in claim 1, it is characterised in that：The preparation method of externally dressing
For：Fresh hypericum japonicum, honeysuckle, oldenlandia diffusa, mock-strawberry and Radix Isatidis are taken by weight ratio, are screened impurity, cleaning, are dried
Water, paste is broken into using beater after mixing, high temperature sterilization sterilization, vacuum compression is packed after cooling, stand-by.
3. the Yao nationality medicine external preparation of the treatment proliferation of mammary gland as claimed in claim 1, it is characterised in that：The preparation method of pulvis
For：Take fresh hypericum japonicum, honeysuckle, oldenlandia diffusa, mock-strawberry and Radix Isatidis by weight ratio, and by raw material stoving, crush
Mixing, 100 mesh sieves are crossed, obtained Chinese medicine powder uses microwave and ultraviolet radiation for sterilizing and disinfecting, packs standby.
4. the Yao nationality medicine external preparation of the treatment proliferation of mammary gland as claimed in claim 1, it is characterised in that：The preparation method of patch
For：
The first step, takes hypericum japonicum, honeysuckle, oldenlandia diffusa, mock-strawberry and Radix Isatidis by weight ratio, and by raw material stoving, powder
Broken mixing, uses microwave and ultraviolet sterilization；
Second step, raw material add the heating of 10-15 times of water to boil 1-2 hours, filtered, and the dregs of a decoction add 5-10 times to measure water to boil 0.5- again again
1 hour, filtering, decoction is combined and concentrated to the concentrate that 60 DEG C of relative densities are 1.2-1.25, cooling, retains filtrate A；
3rd step, the second step filtering gained dregs of a decoction add 3-6 times of 95% ethanol measured, it is small that 4-8 DEG C of standing 6-48 are put in after stirring
When, filtering, refiltered after filtrate is put into the decoction cooling that heating recovery ethanol obtains in ethanol recycling can, and be concentrated into 60 DEG C of phases
To the concentrate that density is 1.2-1.25, retain liquor B；
4th step, filtrate A and liquor B are mixed, then medicine liquid heating is concentrated into paste, are added transdermal promotion absorbent and are stirred
Mix, pressure sensitive adhesive, produce patch.
5. the Yao nationality medicine external preparation of the treatment proliferation of mammary gland as claimed in claim 1, it is characterised in that：The preparation side of externally used paste
Method is：
The first step, takes hypericum japonicum, honeysuckle, oldenlandia diffusa, mock-strawberry and Radix Isatidis by weight ratio, and by raw material stoving, powder
Broken mixing, uses microwave and ultraviolet sterilization；
Second step, raw material add the heating of 10-15 times of water to boil 1-2 hours, filtered, and the dregs of a decoction add 5-10 times to measure water to boil 0.5- again again
1 hour, filtering, decoction is combined and concentrated to the concentrate that 60 DEG C of relative densities are 1.2-1.25, cooling, retains filtrate A；
3rd step, the second step filtering gained dregs of a decoction add 3-6 times of 95% ethanol measured, it is small that 4-8 DEG C of standing 6-48 are put in after stirring
When, filtering, refiltered after filtrate is put into the decoction cooling that heating recovery ethanol obtains in ethanol recycling can, and be concentrated into 60 DEG C of phases
To the concentrate that density is 1.2-1.25, retain liquor B；
4th step, filtrate A and liquor B are mixed, then medicine liquid heating is concentrated into paste, add transdermal promotion absorbent, medical
Vaseline stirs, and produces paste.
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| CN201710894510.1A CN107661391A (en) | 2017-09-28 | 2017-09-28 | Treat Yao nationality medicine external preparation of the proliferation of mammary gland and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116549575A (en) * | 2023-02-09 | 2023-08-08 | 天津市武清区爱康中医医院 | Traditional Chinese medicine composition for treating hyperplasia of mammary glands and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039151A (en) * | 2016-07-13 | 2016-10-26 | 河南中医学院 | External use ointment for treating hyperplasia of mammary glands |
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2017
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039151A (en) * | 2016-07-13 | 2016-10-26 | 河南中医学院 | External use ointment for treating hyperplasia of mammary glands |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116549575A (en) * | 2023-02-09 | 2023-08-08 | 天津市武清区爱康中医医院 | Traditional Chinese medicine composition for treating hyperplasia of mammary glands and preparation method thereof |
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