CN105169342A - Traditional Chinese medicine composition for treating eczema and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating eczema and preparation method thereof Download PDF

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CN105169342A
CN105169342A CN201510654649.XA CN201510654649A CN105169342A CN 105169342 A CN105169342 A CN 105169342A CN 201510654649 A CN201510654649 A CN 201510654649A CN 105169342 A CN105169342 A CN 105169342A
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parts
radix
chinese medicine
medicine composition
rhizoma
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王怀芬
阚积香
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Linyi Caozhimei Pharmaceutical Technology Co Ltd
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Linyi Caozhimei Pharmaceutical Technology Co Ltd
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Abstract

The invention relates to a traditional Chinese medicine composition for treating eczema and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from astragalus membranaceus, gastrodia elata, broom cypress fruits, folium artemisiae argyi, peppers, schizonepeta, cortex dictamni, coptis chinensis, lithospermum, cassia bark, albizia flower, tuber fleeceflower stem, white paeony roots, fresh ginger and liquorice. The traditional Chinese medicine composition has the advantages of relieving itching rapidly, being good in curative effect, and being non-irritant to skin in the aspect for treating eczema. The preparation technology is easy and convenient to implement, the preparation effect is stable, the medication compliance of a patient is high, the application range is wide, and application and popularization are easy.

Description

A kind of Chinese medicine composition for the treatment of eczema and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of eczema, belong to technical field of Chinese medicines.
Background technology
Eczema is a kind of common allergic inflammation dermatoses, and its feature is pleomorphism erythra, oozes out tendency, symmetrical, is easy to recurrence and chronicity.More eczematosis, because of more complicated, thought anaphylactic disease at present, is belonged to type Ⅳ allergy.Anaphylactogen can from the external world, also can from internal body.Enviromental allergen as the toxin of chemical drugs, cosmetics, dyestuff, some animal, foreign preteins and some pollen, the dust etc. such as egg, fish, shrimp, milk.Inner anaphylactogen is as internal lesions, and intestinal parasitic disease, some metabolism, endocrine or digestive tract function imbalance and human body itself are under some is organized in the impact of some factor, and its composition changes and forms autoantibody etc.
The traditional Chinese medical science thinks that this disease is strong mainly due to disease just taste mistake, endogenous dampness, strongly fragrant heat-transformation of a specified duration, retention of damp-heat in the interior, and then rash color is scarlet for outer more skin, contamination flow liquid, and disease is recurrent exerbation for a long time, and cloudy blood is consumed; Qi-blood disharmony, the raw wind of dryness-transformation, failure of skin and muscle to be nourished, coarse plumpness, touching difficulty more.In a word, this disease belongs to damp and hot, and heat in blood, dampness, caused by blood is dry.Clinical should according to the body constitution of patient, arteries and veins card, Selection drug, can not adhere rigidly to into side.
Western medical treatment is based on antihistamine drug for oral administration, medicine for external use is mainly selected the soaks such as solution, lotion, paste or ointment according to different stadium performance or is coated with outward, when there is secondary infection, can consider to use antibiotic therapy, but there is larger toxic and side effects to skin in some Western medicine, the simultaneously treatment such as antibiotic, hormone not only directly can affect the health of patient, and long period or short-term heavy dose use, and addiction also can cause drug dependence dermatitis.
Folium Artemisiae Argyi is the dried leaves of feverfew Chinese mugwort ArtemisiaargyiLevl.etVant., has another name called moxibustion grass, Artemisia argyi Levl. et Van. var. argyi cv. Qiai, Radix Artemisia ordosicae and Ai Peng etc., its bitter in the mouth, pungent, warm in nature; Return liver,spleen,kidney warp; Having blood of regulating the flow of vital energy, warming the meridian for stopping bleeding, the effects such as dispersing cold for relieving pain, is a kind of gynecological good medicine, and for spitting blood, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile.Pharmacological research represents, Folium Artemisiae Argyi all has antibacterial action to various bacteria such as staphylococcus aureus, escherichia coli, bacillus subtilis in vitro, and Oleum Folium Artemisiae Argyi has antagonism to the anaphylactic shock guinea-pigs that ovalbumin causes simultaneously, can reduce mortality rate.Chinese patent application 201210287998.9 discloses a kind of application compress for the treatment of eczema, this medicine is by being immersed in the rice vinegar through boiling cooling respectively by Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli Chinese crude drug, inoculate acetobacter, when different fermentations after indirect fermentation, then its fermentation liquid is blent make.This medicine has certain curative effect in treatment eczema, but this process for preparing medicine is complicated, and treatment is long for the course for the treatment of.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of eczema, and this Chinese medicine composition can Quick itch stopping, and pointed strong, advantage that good effect, relapse rate are low, has good long-term effect.
In addition, the present invention also provides the preparation technology of this Chinese medicine composition, on the basis ensureing curative effect, Chinese medicine is made universality is strong, be easy to carry about with one the finished product preparation used.
The Chinese medicine composition for the treatment of eczema of the present invention is made up of the raw materials of following parts by weight: Radix Astragali 13-19 part, Rhizoma Gastrodiae 12-16 part, Fructus Kochiae 10-20 part, Folium Artemisiae Argyi 18-22 part, Pericarpium Zanthoxyli 13-22 part, Herba Schizonepetae 18-24 part, Cortex Dictamni 12-18 part, Rhizoma Coptidis 10-16 part, Radix Arnebiae (Radix Lithospermi) 18-24 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 12-18 part, Flos Albiziae 15-19 part, Caulis Polygoni Multiflori 14-18 part, Radix Paeoniae Alba 11-17 part, Rhizoma Zingiberis Recens 12-18 part and Radix Glycyrrhizae 6-16 part.
Further, described Chinese medicine composition is made up of the raw materials of following parts by weight: the Radix Astragali 13 parts, 12 parts, Rhizoma Gastrodiae, the Fructus Kochiae 10 parts, Folium Artemisiae Argyi 18 parts, 13 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 18 parts, Cortex Dictamni 12 parts, Rhizoma Coptidis 10 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, 12 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 15 parts, Caulis Polygoni Multiflori 14 parts, the Radix Paeoniae Alba 11 parts, 12 parts, Rhizoma Zingiberis Recens and 6 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is made up of the raw materials of following parts by weight: the Radix Astragali 19 parts, 16 parts, Rhizoma Gastrodiae, the Fructus Kochiae 20 parts, Folium Artemisiae Argyi 22 parts, 22 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 24 parts, Cortex Dictamni 18 parts, Rhizoma Coptidis 16 parts, Radix Arnebiae (Radix Lithospermi) 24 parts, 18 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 19 parts, Caulis Polygoni Multiflori 18 parts, the Radix Paeoniae Alba 17 parts, 18 parts, Rhizoma Zingiberis Recens and 16 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is made up of the raw materials of following parts by weight: the Radix Astragali 16 parts, 14 parts, Rhizoma Gastrodiae, the Fructus Kochiae 15 parts, Folium Artemisiae Argyi 20 parts, 17 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 22 parts, Cortex Dictamni 16 parts, Rhizoma Coptidis 14 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, 16 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 16 parts, Caulis Polygoni Multiflori 16 parts, the Radix Paeoniae Alba 15 parts, 16 parts, Rhizoma Zingiberis Recens and 10 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is made into paste, gel, ointment, ointment or liniment.
In addition, the preparation method of Chinese medicine composition of the present invention comprises the following steps:
S1: get Rhizoma Gastrodiae and clean, crushed after being dried, cross 80-100 mesh sieve, adding Rhizoma Gastrodiae coarse powder weight 8-12 times amount volume fraction is the ethanol of 60-80%, soak 6-12 hour, supersound extraction twice at 44-65 DEG C of temperature, each 30-50 minute, supersonic frequency is 20-30kHz, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is the clear paste of 1.10-1.20, obtains Rhizoma Gastrodiae extract;
S2: get the Radix Astragali, the Fructus Kochiae and Folium Artemisiae Argyi, pulverizes, adds the ethanol of the concentration 75-80% of above-mentioned coarse powder total amount 4-6 times weight, reflux, extract, 2-3 time, each 2-5 hour, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of-60 DEG C of relative densities be the Chinese medical concrete of 1.20-1.30;
S3: get Pericarpium Zanthoxyli, Herba Schizonepetae, Cortex Dictamni, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae, Caulis Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens and Radix Glycyrrhizae and be pulverized and mixed, adds the water soaking 12-24 hour of above-mentioned coarse powder gross weight 8-10 times amount, decocts 1-3 hour; Filter, merge twice filtrate, it is the Chinese medical concrete of 1.20-1.30 that filtrate is concentrated into relative density at 50 DEG C-60 DEG C;
S4: the Chinese medical concrete that the Rhizoma Gastrodiae extract obtained by step S1 and step S2 obtain and the Chinese medical concrete that step S3 obtains mix, and dry, pulverize, to obtain final product.
Source, the nature and flavor of Chinese medicine composition of the present invention Chinese crude drug used, return through and effect:
The Radix Astragali: be the dry root of leguminous plant Radix Astragali or Radix Astagali; Sweet, tepor; Return lung, spleen, liver, kidney channel; Have tonifying Qi and lifting yang, function that benefit defends consolidating superficial resistance.
Rhizoma Gastrodiae: the dry tuber of the orchid family Gastrodia plant Rhizoma Gastrodiae, taste taste, sweet, property is put down; Return Liver Channel; Endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral.
The Fructus Kochiae: this product is the dry mature fruit of the chenopod Fructus Kochiae; Acrid in the mouth, hardship, cold in nature; Return kidney, urinary bladder channel; Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort; Acrid in the mouth, hardship, warm in nature; Return spleen, liver, kidney channel; To regulate the flow of vital energy blood, by cold-damp, dispersing cold for relieving pain, warming the meridian for stopping bleeding.
Pericarpium Zanthoxyli: this product is dry mature skin (Pericarpium Zanthoxyli) and the seed (Semen zanthoxyli) of rutaceae Capsicum annuum L. (fragrant green pepper, Zanthoxylum schinifolium, Pericarpium Zanthoxyli, Canis familiaris L. green pepper) or Pericarpium Zanthoxyli (another name for Sichuan Province green pepper, Fructus Zanthoxyli, Capsicum tetragonum, pericarpium zanthoxyli bungeani, Radix Campylotropis Hirtella (Herba Myrsines Africanae)); Acrid in the mouth, warm in nature; Return spleen, stomach, kidney channel; Warming spleen and stomach for dispelling cold, removing damp and stopping pain, killing parasites for relieving itching.
Herba Schizonepetae: this product is the dry aerial parts of labiate Herba Schizonepetae; Acrid in the mouth, slightly warm in nature; Return lung, Liver Channel; Induce sweat loose wind, rash.
Cortex Dictamni: this product is the dry root bark of rutaceae shaggy-fruited dittany; Bitter in the mouth, cold in nature; Return spleen, stomach, urinary bladder channel; Heat clearing and damp drying, dispelling wind for relieving itching, removing toxic substances.
Rhizoma Coptidis: this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall; Bitter in the mouth, cold in nature; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication.
Radix Arnebiae (Radix Lithospermi): this product is the dry root of comfrey lithospermum euchromum Royle, Radix Arnebiae (Radix Lithospermi) or arnebia guttata Bunge; Sweet in the mouth, salty, cold in nature; GUIXIN, Liver Channel; Removing heat from blood, invigorates blood circulation, removing toxic substances rash.
Cortex cinnamomi japonici (Ramulus Cinnamomi): this product is the bark in canella Cinnamomum japonica, cloudy perfume, cinnamomum chingii Metcalf or osmanthus, river etc.; Acrid in the mouth, sweet, warm in nature; Return spleen, stomach, liver, kidney channel; Warming the spleen stomach, warm Liver and kidney, cold-dispelling pain-relieving, dissipating blood stasis for subsidence of swelling.
Flos Albiziae: this product is the dry inflorescence of leguminous plant Herba Albiziae; Sweet in the mouth, property is put down; GUIXIN, Liver Channel; Shu Yu, regulates the flow of vital energy, and calms the nerves, active.
Caulis Polygoni Multiflori: be rattan or the leaf bine stem of polygonum multiflorum thunb; Sweet in the mouth, micro-hardship, property is put down; GUIXIN, Liver Channel;
Tranquilizing by nourishing the heart, dispels the wind, dredging collateral.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae; Bitter in the mouth, acid, cold nature; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Rhizoma Zingiberis Recens: this product is the fresh rhizome of zingiber; Acrid in the mouth, slightly warm in nature; Return lung, spleen, stomach warp; Induce sweat cold expelling.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
Chinese medicine composition of the present invention is with the Radix Astragali, Rhizoma Gastrodiae, the Fructus Kochiae, Folium Artemisiae Argyi, Herba Schizonepetae, Pericarpium Zanthoxyli for monarch drug, warming middle-JIAO to relieve pain, detoxifying and relieving itching; With Cortex Dictamni, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi) for ministerial drug, removing toxic substances rash, heat clearing and damp drying, eliminating fire and detoxication; With Caulis Polygoni Multiflori, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens for adjuvant drug, tranquilizing by nourishing the heart, expelling pus and toxin by strengthening QI; With Radix Glycyrrhizae for making medicine, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription, makes all medicines arrange in pairs or groups, jointly reaches sterilizing and itch-relieving, and removing toxic substances rash, expelling pus and toxin by strengthening QI, effect of promoting tissue regeneration and ulcer healing, has significant therapeutic effect to eczema.
Through clinical trial checking, Chinese medicine composition of the present invention has following advantage compared with existing medicine:
1) the present invention significantly can improve the symptom of eczema, rapid-action, treatment short treating period, and can suppress secondary infection.
2) Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and toxic and side effects is little, to no skin irritation.
3) Chinese medicine composition synergism of the present invention is strong, and using dosage is little, can not produce drug dependence simultaneously.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
eXAMPLE l
The embodiment of the present invention 1 Chinese medicine composition is made up of the raw materials of following parts by weight: the Radix Astragali 13 parts, 12 parts, Rhizoma Gastrodiae, the Fructus Kochiae 10 parts, Folium Artemisiae Argyi 18 parts, 13 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 18 parts, Cortex Dictamni 12 parts, Rhizoma Coptidis 10 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, 12 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 15 parts, Caulis Polygoni Multiflori 14 parts, the Radix Paeoniae Alba 11 parts, 12 parts, Rhizoma Zingiberis Recens and 6 parts, Radix Glycyrrhizae.
Preparation method:
S1: get Rhizoma Gastrodiae and clean, crushed after being dried, cross 80 mesh sieves, adding Rhizoma Gastrodiae coarse powder weight 8 times amount volume fraction is the ethanol of 60%, soak 6 hours, supersound extraction twice at 44 DEG C of temperature, each 30 minutes, supersonic frequency was 20kHz, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is the clear paste of 1.10, obtains Rhizoma Gastrodiae extract;
S2: get the Radix Astragali, the Fructus Kochiae and Folium Artemisiae Argyi, pulverizes, adds the ethanol of the concentration 75% of above-mentioned coarse powder total amount 4 times of weight, reflux, extract, 2 times, each 2 hours, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be the Chinese medical concrete of 1.20;
S3: get Pericarpium Zanthoxyli, Herba Schizonepetae, Cortex Dictamni, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae, Caulis Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens and Radix Glycyrrhizae and be pulverized and mixed, adds the water soaking 12 hours of above-mentioned coarse powder gross weight 8 times amount, decocts 1 hour; Filter, merge twice filtrate, it is the Chinese medical concrete of 1.20 that filtrate is concentrated into relative density at 50 DEG C;
S4: the Chinese medical concrete that the Rhizoma Gastrodiae extract obtained by step S1 and step S2 obtain and the Chinese medical concrete that step S3 obtains mix, and dry, pulverize, add corresponding adjuvant, make ointment.
embodiment 2
The embodiment of the present invention 2 Chinese medicine composition is made up of the raw materials of following parts by weight: the Radix Astragali 19 parts, 16 parts, Rhizoma Gastrodiae, the Fructus Kochiae 20 parts, Folium Artemisiae Argyi 22 parts, 22 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 24 parts, Cortex Dictamni 18 parts, Rhizoma Coptidis 16 parts, Radix Arnebiae (Radix Lithospermi) 24 parts, 18 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 19 parts, Caulis Polygoni Multiflori 18 parts, the Radix Paeoniae Alba 17 parts, 18 parts, Rhizoma Zingiberis Recens and 16 parts, Radix Glycyrrhizae.
Preparation method is similar with embodiment 1, makes ointment.
embodiment 3
The embodiment of the present invention 3 Chinese medicine composition is made up of the raw materials of following parts by weight: the Radix Astragali 16 parts, 14 parts, Rhizoma Gastrodiae, the Fructus Kochiae 15 parts, Folium Artemisiae Argyi 20 parts, 17 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 22 parts, Cortex Dictamni 16 parts, Rhizoma Coptidis 14 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, 16 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 16 parts, Caulis Polygoni Multiflori 16 parts, the Radix Paeoniae Alba 15 parts, 16 parts, Rhizoma Zingiberis Recens and 10 parts, Radix Glycyrrhizae.
Preparation method is similar with embodiment 1, makes gel.
chinese medicine composition pharmacodynamic study of the present invention
test one: Chinese medicine composition of the present invention is to the development test of ear eczema mice
Experimental animal: provide cleaning grade kunming mice 36 by certain Bioisystech Co., Ltd, body weight 22g ± 4g, male and female half and half.36 mices are divided into 3 groups at random, often organize 12.
Ear eczema Establishment of mouse model: first day is in two-sided dinitrochlorobenzene (DNCB) the solution sensitization of smearing 40 μ L5% of mice ears, within 4th day, smear the DNCB solution of 40 μ L1%, once smeared once every four days afterwards, totally 5 times, set up ear eczema mouse model.
Dosage regimen:
Treatment group: get the Chinese medicine composition ointment of the present invention that the embodiment of the present invention 1 is obtained; Smear DNCB excites rear 24h, 48h, 72h to be coated with trial drug outward inside mice ears at every turn, and 1g/ is each, 2 times/day.
Positive controls: get Compound Dexamethasone Cream (Baiyunshan Hejigong Medicine Factory of Guangzhou Baiyunshan Pharmaceutical Co., Ltd., the accurate word H44024298 of traditional Chinese medicines), dosage regimen is with A group.
Model control group: the ointment getting not drug containing in the embodiment of the present invention 1, the same treatment group of dosage regimen.
Carry out the score of skin lesion degree by following standard: the obvious redness of ears thickens and oozes out, or obviously keratinization incrustation person remembers 3 points; Mild redness, oozes out not obvious, or moderate keratinization person is designated as 2 points; Red and swollen and ooze out all not obvious person, or slight keratinization person is designated as 1 point; Normal skin is 0 point.
Use spiral micrometer to measure ear swelling thickness respectively simultaneously.
Table 1 Ge Zu ear skin lesion situation compares
Note: compare with model control group, * p< 0.05; * p< 0.01.
Adopt other embodiment medicines to test, achieve similar therapeutic effect.
Treatment group is compared with model control group, and mouse ear skin lesion integration and ear swelling thickness all have significant difference.Test data shows, treatment group mice is compared with model control group mice, and ear's skin lesion is clearly better, and ear swelling degree obviously reduces, and result of the test shows, traditional Chinese medicine composition for treating of the present invention and prevention eczema successful, can be used for clinical expansion.
test two: the clinical trial of Chinese medicine composition of the present invention
One, diagnostic criteria
Draft with reference to the content of " diagnosis basis of eczema " in " Chinese medical disease Standardization of diagnosis and curative effect ".Diagnostic criteria is:
1, acute eczema:
1) skin lesion is pleomorphism, as flushing, pimple, vesicle, erosion, ooze out, crust, desquamation, constant kind form exists simultaneously.
2) onset is anxious, conscious scorching hot, violent pruritus.
3) skin lesion is often symmetrical, common with places such as head, face, distal limbs, scrotum.Can general whole body.
4) subacute or chronic eczema can be developed into, time light time heavy, repeatedly do not heal.
2, subacute eczema: skin lesion oozes out less, based on pimple, papulovesicle, incrustation, squama.Have slight rotten to the corn face, color is more dark red.Also visible mild infiltration, violent pruritus.
3, chronic eczema: many limits office is in a certain position, and boundary is clear, have significantly plump infiltration, rough surface, or become in lichen sample, the brown red or brown of color, often with papulovesicle, crust, scratch.Be inclined to moistening change, normal recurrent exerbation, time light time heavy, have paroxysmal pruritus.
Two, clinical trial protocol
1, subjects basic document:
The present invention collect clinical eczema volunteer 120 example, man 88 example, female 32 example, age 15-45 year, all experimenters are divided at random 2 groups, often organize 60,2 group case in sex, age, the course of disease etc. through statistical analysis, there is comparability.
2, trial drug and test method:
Treatment group: ointment prepared by the embodiment of the present invention 1, often prop up ointment and contain medicine 12.5g, spread upon eczema place, every day, secondary, smeared 10 days continuously.
Positive controls: smear Compound Dexamethasone Cream (Baiyunshan Hejigong Medicine Factory of Guangzhou Baiyunshan Pharmaceutical Co., Ltd., the accurate word H44024298 of traditional Chinese medicines), twice daily, smear 10 days continuously.
3, criterion of therapeutical effect:
Effective: eczema erythema obviously reduces, attack times reduces.
Invalid: compare with before treatment, symptom does not disappear or increases the weight of on the contrary.
Recurrence: cure latter 3 months and run into warm and still show effect.
4, therapeutic outcome: as shown in table 2.
Table 2 therapeutic effect
Result of the test shows, the effect for the treatment of group traditional Chinese medicine composition for treating eczema of the present invention is better than positive control drug Compound Dexamethasone Cream.Treatment group is compared with positive controls, the total effective rate for the treatment of group is 96.7%, and higher than the total effective rate 86.7% of positive controls group, and the recurrence number of cases for the treatment of group is significantly lower than the recurrence number of cases of positive controls, clinical observation, treatment group patient has no any untoward reaction at therapeutic process.Traditional Chinese medicine composition for treating eczema of the present invention is rapid-action, and safety is high, and relapse rate is low, and clinical generalization value is high.

Claims (6)

1. treat the Chinese medicine composition of eczema for one kind, it is characterized in that, described Chinese medicine composition is made up of the raw materials of following weight portion: Radix Astragali 13-19 part, Rhizoma Gastrodiae 12-16 part, Fructus Kochiae 10-20 part, Folium Artemisiae Argyi 18-22 part, Pericarpium Zanthoxyli 13-22 part, Herba Schizonepetae 18-24 part, Cortex Dictamni 12-18 part, Rhizoma Coptidis 10-16 part, Radix Arnebiae (Radix Lithospermi) 18-24 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 12-18 part, Flos Albiziae 15-19 part, Caulis Polygoni Multiflori 14-18 part, Radix Paeoniae Alba 11-17 part, Rhizoma Zingiberis Recens 12-18 part and Radix Glycyrrhizae 6-16 part.
2. the Chinese medicine composition for the treatment of eczema according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the raw materials of following parts by weight: the Radix Astragali 13 parts, 12 parts, Rhizoma Gastrodiae, the Fructus Kochiae 10 parts, Folium Artemisiae Argyi 18 parts, 13 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 18 parts, Cortex Dictamni 12 parts, Rhizoma Coptidis 10 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, 12 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 15 parts, Caulis Polygoni Multiflori 14 parts, the Radix Paeoniae Alba 11 parts, 12 parts, Rhizoma Zingiberis Recens and 6 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of eczema according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the raw materials of following parts by weight: the Radix Astragali 19 parts, 16 parts, Rhizoma Gastrodiae, the Fructus Kochiae 20 parts, Folium Artemisiae Argyi 22 parts, 22 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 24 parts, Cortex Dictamni 18 parts, Rhizoma Coptidis 16 parts, Radix Arnebiae (Radix Lithospermi) 24 parts, 18 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 19 parts, Caulis Polygoni Multiflori 18 parts, the Radix Paeoniae Alba 17 parts, 18 parts, Rhizoma Zingiberis Recens and 16 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of eczema according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the raw materials of following parts by weight: the Radix Astragali 16 parts, 14 parts, Rhizoma Gastrodiae, the Fructus Kochiae 15 parts, Folium Artemisiae Argyi 20 parts, 17 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 22 parts, Cortex Dictamni 16 parts, Rhizoma Coptidis 14 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, 16 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 16 parts, Caulis Polygoni Multiflori 16 parts, the Radix Paeoniae Alba 15 parts, 16 parts, Rhizoma Zingiberis Recens and 10 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition of the treatment eczema according to any one of claim 1-4, is characterized in that: described Chinese medicine composition is made into paste, gel, ointment, ointment or liniment.
6. prepare a method for the Chinese medicine composition of the treatment eczema according to any one of claim 1-4, it is characterized in that comprising the following steps:
S1: get Rhizoma Gastrodiae and clean, crushed after being dried, cross 80-100 mesh sieve, adding Rhizoma Gastrodiae coarse powder weight 8-12 times amount volume fraction is the ethanol of 60-80%, soak 6-12 hour, supersound extraction twice at 44-65 DEG C of temperature, each 30-50 minute, supersonic frequency is 20-30kHz, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is the clear paste of 1.10-1.20, obtains Rhizoma Gastrodiae extract;
S2: get the Radix Astragali, the Fructus Kochiae and Folium Artemisiae Argyi, pulverizes, adds the ethanol of the concentration 75-80% of above-mentioned coarse powder total amount 4-6 times weight, reflux, extract, 2-3 time, each 2-5 hour, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of-60 DEG C of relative densities be the Chinese medical concrete of 1.20-1.30;
S3: get Pericarpium Zanthoxyli, Herba Schizonepetae, Cortex Dictamni, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae, Caulis Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens and Radix Glycyrrhizae and be pulverized and mixed, adds the water soaking 12-24 hour of above-mentioned coarse powder gross weight 8-10 times amount, decocts 1-3 hour; Filter, merge twice filtrate, it is the Chinese medical concrete of 1.20-1.30 that filtrate is concentrated into relative density at 50 DEG C-60 DEG C;
S4: the Chinese medical concrete that the Rhizoma Gastrodiae extract obtained by step S1 and step S2 obtain and the Chinese medical concrete that step S3 obtains mix, and dry, pulverize, to obtain final product.
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Application publication date: 20151223