CN105311331A - Traditional Chinese medicine composition for treating eczema and preparation method thereof - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating eczema and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-20 parts of horseradish tree leaves, 3-12 parts of bark of Chinese corktree, 9-15 parts of belveder fruit, 3-12 parts of light yellow sophora root, 3-10 parts of Chinese yam, 3-10 parts of milkvetch root, 3-10 parts of rhizome of swordlike atractylodes, 3-10 parts of tuckahoe, 3-8 parts of root of doubleteeth pubescent angelica, 3-8 parts of plantain seed, 1-3 parts of cablin potchouli herb and 1-12 parts of licorice root. The traditional Chinese medicine composition provided by the invention adopts natural traditional Chinese medicines, is simple in ingredient, reasonable in mixing ratio, small in toxic or side effects and convenient in use, has the effects of eliminating dampness to relieve itching, clearing away heat and toxic materials and reinforcing the spleen to replenish qi, and also has the advantages of being simple in preparation process, good in curative effect, low in side effect, convenient to take and easy to popularize and apply.

Description

A kind of Chinese medicine composition for the treatment of eczema and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of eczema and preparation method thereof.

Background technology

Eczema is the struvite anaphylaxis dermatosis of a kind of common epidermis caused by multiple internal and external factor and high dermis, and it is generally acknowledged has certain relation with allergy, point acute, subacute, chronic three phases.Acute stage, tool oozed out tendency, and chronic phase then infiltrates, plumpness.Some patient directly translates into chronic eczema, and skin lesion has pleomorphism, symmetry, pruritus and the easy feature such as recurrent exerbation, ancients are referred to as " acute eczema ", " eczema of ear ", " eczema of scrotum ", " infantile eczema " etc.Any age, any position, any season can be betided, but be everlasting recurrence in winter or aggravation.Primary disease as treated not in time and thoroughly, then can cause secondary infection, skin injury, desquamation etc., even can cause malnutrition, degradation under resistance.

Eczematosis, because of complexity, is often internal and external reasons interaction result.Endogenous cause of ill is as chronic digestive system disease, psychentonia, insomnia, overtired, emotion changes, endocrine disturbance, infection, dysbolism etc., and exopathogenic factor such as living environment, climate change, food etc. all can affect the generation of eczema.Environmental stimuli as daylight, cold, drying, sweltering heat, hot water is scalded and various animal skin, plant, cosmetics, soap, staple fibre etc. all can bring out.

In doctor trained in Western medicine, eczema is the very complicated disease relevant with immunity of a kind of cause of disease, still can not effect a radical cure at present, can only control with medicine.This sick Chinese traditional treatment effect is better, the traditional Chinese medical science think this disease main and damprelevant, wet can intrinsic heat, send out as damp and hot card, the wet then impairment of the spleen of a specified duration, heat then impairment of YIN blood, and cause deficiency and excessthe card be mingled with.The common damp and hot card of acute eczema, chronic eczema mostly is the card of simulataneous insufficiency and excessive, because damp exists, therefore recurrent exerbation.

Chinese invention patent application 201410405955.5 relates to a kind of externally-applied liniment for the treatment of eczema, and this liniment comprises following Chinese crude drug: Cortex Moutan, Radix Sanguisorbae, Semen Plantaginis, Radix Sophorae Flavescentis, Os Draconis, Herba Artemisiae Annuae, Fructus Cnidii, Fructus Gardeniae, Flos Caryophylli, Radix Glycyrrhizae, Cortex Phellodendri, Rhizoma Coptidis and Chinese liquor.This externally-applied liniment take Chinese medicine composition as main component, Nantural non-toxic side effect, and relative to western medical treatment, it has good therapeutic effect to eczema, but effect in invigorating the spleen and benefiting QI, heat-clearing and toxic substances removing is not remarkable.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition being used for the treatment of eczema, this Chinese medicine composition has removing dampness to relieve itching, heat-clearing and toxic substances removing, effect of invigorating the spleen and benefiting QI, also have that preparation technology is simple, good effect, side effect be low, taking convenience and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition

For realizing object of the present invention, technical solution of the present invention is as follows:

Chinese medicine composition of the present invention is prepared from by the raw material of following parts by weight: leaf of Moringa 6-20 part, Cortex Phellodendri 3-12 part, Fructus Kochiae 9-15 part, Radix Sophorae Flavescentis 3-12 part, Rhizoma Dioscoreae 3-10 part, Radix Astragali 3-10 part, Rhizoma Atractylodis 3-10 part, Poria 3-10 part, Radix Angelicae Pubescentis 3-8 part, Semen Plantaginis 3-8 part, Herba Pogostemonis 1-3 part and Radix Glycyrrhizae 1-12 part.

Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 6 parts, Cortex Phellodendri 3 parts, the Fructus Kochiae 9 parts, Radix Sophorae Flavescentis 3 parts, Rhizoma Dioscoreae 3 parts, the Radix Astragali 3 parts, Rhizoma Atractylodis 3 parts, 3 parts, Poria, Radix Angelicae Pubescentis 3 parts, Semen Plantaginis 3 parts, Herba Pogostemonis 1 part and 5 parts, Radix Glycyrrhizae.

Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 20 parts, Cortex Phellodendri 12 parts, the Fructus Kochiae 15 parts, Radix Sophorae Flavescentis 12 parts, Rhizoma Dioscoreae 10 parts, the Radix Astragali 10 parts, Rhizoma Atractylodis 10 parts, 10 parts, Poria, Radix Angelicae Pubescentis 8 parts, Semen Plantaginis 8 parts, Herba Pogostemonis 3 parts and 12 parts, Radix Glycyrrhizae.

Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 12 parts, Cortex Phellodendri 9 parts, the Fructus Kochiae 12 parts, Radix Sophorae Flavescentis 6 parts, Rhizoma Dioscoreae 6 parts, the Radix Astragali 6 parts, Rhizoma Atractylodis 6 parts, 6 parts, Poria, Radix Angelicae Pubescentis 5 parts, Semen Plantaginis 5 parts, Herba Pogostemonis 2 parts and 10 parts, Radix Glycyrrhizae.

Further, described Chinese medicine composition is made into ointment, gel, ointment or cream.

Further, described Chinese medicine composition is obtained by following steps:

S1: get leaf of Moringa, clean, crushed after being dried becomes coarse powder, and cross 90-150 mesh sieve, adding described coarse powder total amount 6-10 times amount volume fraction is the ethanol of 60-75%, add the Snailase of coarse powder total amount 1.5%-3% again, lixiviate 2-5 hour at 38-45 DEG C, then at 80-90 DEG C of reflux, extract, 3-7 hour, filters, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract A;

S2: get Cortex Phellodendri, the Fructus Kochiae, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, the Radix Astragali, Rhizoma Atractylodis, Poria, Radix Angelicae Pubescentis, Semen Plantaginis, Herba Pogostemonis and Radix Glycyrrhizae, clean, crushed after being dried becomes coarse powder, adding described coarse powder gross weight 10-18 times amount volume fraction is the ethanol of 60-80%, microwave extraction 10-15 minute, and microwave power is 450-600W, Extracting temperature is 45-60 DEG C, filter and retain filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract B;

S3: extract A mixed with extract B, stirs, and continuing to be evaporated to relative density at 60 DEG C is the extractum of 1.30-1.35, to obtain final product.

Correspondingly, the preparation method of described Chinese medicine composition comprises following step:

S1: get leaf of Moringa, clean, crushed after being dried becomes coarse powder, and cross 90-150 mesh sieve, adding described coarse powder total amount 6-10 times amount volume fraction is the ethanol of 60-75%, add the Snailase of coarse powder total amount 1.5%-3% again, lixiviate 2-5 hour at 38-45 DEG C, then at 80-90 DEG C of reflux, extract, 3-7 hour, filters, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract A;

S2: get Cortex Phellodendri, the Fructus Kochiae, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, the Radix Astragali, Rhizoma Atractylodis, Poria, Radix Angelicae Pubescentis, Semen Plantaginis, Herba Pogostemonis and Radix Glycyrrhizae, clean, crushed after being dried becomes coarse powder, adding described coarse powder gross weight 10-18 times amount volume fraction is the ethanol of 60-80%, microwave extraction 10-15 minute, and microwave power is 450-600W, Extracting temperature is 45-60 DEG C, filter and retain filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract B;

S3: extract A mixed with extract B, stirs, and continuing to be evaporated to relative density at 60 DEG C is the extractum of 1.30-1.35, to obtain final product.

Source, the nature and flavor of Chinese prescription of the present invention Chinese crude drug used, return through and effect:

Leaf of Moringa: this product is the leaves of perennial tropical deciduous tree Moringa tree (being also called drumstick tree); Acrid in the mouth, slightly warm in nature, has enhancing immunity, enhances metabolism, and can be used for treatment skin allergy, eczema, skin itches.

Cortex Phellodendri: this product is the dry bark of rutaceae wampee or Cortex Phellodendri; Bitter in the mouth, cold in nature; Return kidney, urinary bladder channel; Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.

The Fructus Kochiae: this product is the dry mature fruit of chenopod Fructus Kochiae; Acrid in the mouth, hardship, cold in nature; Return kidney, urinary bladder channel; Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.

Radix Sophorae Flavescentis: this product is the dry root of leguminous plant Radix Sophorae Flavescentis; Bitter in the mouth, cold in nature; GUIXIN, liver, stomach, large intestine, urinary bladder channel; Heat clearing and damp drying, parasite killing, diuresis.

Rhizoma Dioscoreae: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae; Sweet in the mouth is flat; Return spleen, lung, kidney channel; Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.

The Radix Astragali: this product is the dry root of leguminous plant Radix Astagali or Radix Astragali; Sweet in the mouth, temperature; Return lung, spleen channel; Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.

Rhizoma Atractylodis: this product is the rhizome of feverfew RHIZOMA ATRACTYLODIS IANCEAE or Atractylis chinensis etc.; Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, Liver Channel; Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.

Poria: this product is the dry sclerotia of Polyporaceae plant Poria; Sweet in the mouth, light, property is put down; GUIXIN, lung, spleen, kidney channel; Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.

Radix Angelicae Pubescentis: this product is the dry root of samphire Angelica pubescens; Acrid in the mouth, hardship, tepor; Return kidney, urinary bladder channel; Expelling wind and removing dampness, numbness relieving and pain relieving.

Semen Plantaginis: this product is the seed of Plantaginaceae plant Herba Plantaginis or Plantago depressa Willd.Sweet in the mouth, cold nature; Return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.

Radix agastaches: this product is the aerial parts of labiate Herba Pogostemonis; Property is pungent, tepor; Enter lung, spleen, stomach warp; Fast gas, and in, ward off dirty, damp eliminating.

Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

The compatibility analysis of Chinese prescription of the present invention:

Chinese prescription of the present invention to the dialectical cognition of eczema, follows the compatibility theory of Chinese medicine according to the traditional Chinese medical science, facilitating the easy-to-use and preparation of stable curative effect, enhancing the use amount of medical material to make.This prescription is with leaf of Moringa and Cortex Phellodendri for monarch drug, detoxifying, removing dampness, dispelling wind for relieving itching; With the Fructus Kochiae, Radix Angelicae Pubescentis, Semen Plantaginis, Herba Pogostemonis, Rhizoma Atractylodis, Radix Sophorae Flavescentis for ministerial drug, dispelling wind for relieving itching, heat clearing and damp drying, eliminating blood stasis and inducing menstruation; With Poria, Rhizoma Dioscoreae, the Radix Astragali for adjuvant drug, promoting diuresis to eliminate damp pathogen, spleen invigorating QI invigorating; With Radix Glycyrrhizae for making medicine, the coordinating the actions of various ingredients in a prescription property of medicine, all medicines coordinate, and complement each other, synergism, plays the effects such as dispelling wind for relieving itching, promoting diuresis to eliminate damp pathogen, invigorating the spleen and benefiting QI altogether, have very significant curative effect to eczema.

Compared with prior art, the present invention has following technical advantage:

1, Chinese medicine composition of the present invention is compared with the medicine of other treatment eczema, and at heat-clearing and toxic substances removing, the aspects such as invigorating the spleen and benefiting QI have more remarkable efficacy.

2, compared with the chemotherapeutic agent of Current therapeutic eczema, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, efficiently solve the morbidity root of hemorrhoid, and improve the quality of life of patient.

3, Chinese medicine composition of the present invention also has that compatibility science, preparation technology are simple, good effect, side effect are low, taking convenience and be easy to advantages such as applying.

Detailed description of the invention

It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.

embodiment 1:

The embodiment of the present invention 1 Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 6 parts, Cortex Phellodendri 3 parts, the Fructus Kochiae 9 parts, Radix Sophorae Flavescentis 3 parts, Rhizoma Dioscoreae 3 parts, the Radix Astragali 3 parts, Rhizoma Atractylodis 3 parts, 3 parts, Poria, Radix Angelicae Pubescentis 3 parts, Semen Plantaginis 3 parts, Herba Pogostemonis 1 part and 5 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1: get leaf of Moringa 6 parts, clean, crushed after being dried becomes coarse powder, and cross 100 mesh sieves, adding described coarse powder total amount 6 times amount volume fraction is the ethanol of 75%, add the Snailase of medical material total amount 1.5% again, lixiviate 2 hours at 38 DEG C, then 80 DEG C of reflux, extract, 4 hours, filters, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtained extract A;

S2: get Cortex Phellodendri 3 parts, the Fructus Kochiae 9 parts, Radix Sophorae Flavescentis 3 parts, Rhizoma Dioscoreae 3 parts, the Radix Astragali 3 parts, Rhizoma Atractylodis 3 parts, 3 parts, Poria, Radix Angelicae Pubescentis 3 parts, Semen Plantaginis 3 parts, Herba Pogostemonis 1 part and 5 parts, Radix Glycyrrhizae, clean, crushed after being dried becomes coarse powder, adding described coarse powder gross weight 10 times amount volume fraction is the ethanol of 60%, microwave extraction 10 minutes, and microwave power is 450W, Extracting temperature is 45 DEG C, filter and retain filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtained extract B;

S3: extract A mixed with extract B, stirs, and continuing to be evaporated to relative density at 60 DEG C is the extractum of 1.30, adds corresponding adjuvant, makes ointment with modern Chinese medicine preparation common process.

embodiment 2:

The embodiment of the present invention 2 Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 20 parts, Cortex Phellodendri 12 parts, the Fructus Kochiae 15 parts, Radix Sophorae Flavescentis 12 parts, Rhizoma Dioscoreae 10 parts, the Radix Astragali 10 parts, Rhizoma Atractylodis 10 parts, 10 parts, Poria, Radix Angelicae Pubescentis 8 parts, Semen Plantaginis 8 parts, Herba Pogostemonis 3 parts and 12 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1: get leaf of Moringa 20 parts, clean, crushed after being dried becomes coarse powder, and cross 120 mesh sieves, adding described coarse powder total amount 8 times amount volume fraction is the ethanol of 75%, add the Snailase of medical material total amount 2% again, lixiviate 3 hours at 40 DEG C, then 85 DEG C of reflux, extract, 5 hours, filters, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.20, obtained extract A;

S2: get Cortex Phellodendri 12 parts, the Fructus Kochiae 15 parts, Radix Sophorae Flavescentis 12 parts, Rhizoma Dioscoreae 10 parts, the Radix Astragali 10 parts, Rhizoma Atractylodis 10 parts, 10 parts, Poria, Radix Angelicae Pubescentis 8 parts, Semen Plantaginis 8 parts, Herba Pogostemonis 3 parts and 12 parts, Radix Glycyrrhizae, clean, crushed after being dried becomes coarse powder, adding described coarse powder gross weight 12 times amount volume fraction is the ethanol of 75%, microwave extraction 10 minutes, and microwave power is 500W, Extracting temperature is 50 DEG C, filter and retain filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.20, obtained extract B;

S3: extract A mixed with extract B, stirs, and continuing to be evaporated to relative density at 60 DEG C is the extractum of 1.30, adds corresponding adjuvant, makes cream with modern Chinese medicine preparation common process.

embodiment 3:

The embodiment of the present invention 3 Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 12 parts, Cortex Phellodendri 9 parts, the Fructus Kochiae 12 parts, Radix Sophorae Flavescentis 6 parts, Rhizoma Dioscoreae 6 parts, the Radix Astragali 6 parts, Rhizoma Atractylodis 6 parts, 6 parts, Poria, Radix Angelicae Pubescentis 5 parts, Semen Plantaginis 5 parts, Herba Pogostemonis 2 parts and 10 parts, Radix Glycyrrhizae.

Preparation method is as embodiment 1.

chinese medicine composition pharmacodynamic study of the present invention

test one: Chinese medicine composition of the present invention is to the influence research of mice eczema

1, experimental animal: get ICR mice (SPF level) 60, body weight is 25-30g.

2, test objective: according to the requirement of " new Chinese medicine pharmaceutical research guide ", studies the Pharmacodynamics of Chinese medicine composition of the present invention in treatment eczema.Take the embodiment of the present invention 1 gained Chinese medicine ointment, by tissue pathology checking, observe its high, medium and low dosage to the impact of chronic eczema mouse model.

3, test method and grouping:

Wherein 50 mice same positions ventral seta (about 2cm × 2cm) are removed with electric hair cutter, after 1 day, 0.5%2 is measured with sample injector, 4-dinitrochlorobenzene (DNCB) solution 20 μ l, be applied in wherein 50 mouse web portion cropping districts and excite sensitization, excite 1 time every 3 days, totally 4 times, set up chronic eczema mouse model, other 10 non-unhairing mices are Normal group.

The chronic eczema mouse model established is divided into 5 groups at random, be respectively the high dose group (25mg/Kg) of Chinese medicine composition embodiment 1 gained Chinese medicine ointment of the present invention, middle dosage group (10mg/Kg), low dose group (5mg/Kg), PIYANPING group and model group, PIYANPING group and model group give (China Resources Sanjiu Medical & Pharmaceutical Co., Ltd.'s production of 15mg/Kg PIYANPING respectively; The accurate word H44024170 of traditional Chinese medicines) and isometric(al) normal saline process, control occurrence condition and high dose group, middle dosage group is identical with low dose group.Be applied to mouse skin Sensitizing area respectively, every day 2 times, continuous use 15 days.Medication is after 15 days, and clip excites position and control group mice skin, steeps in 10% formalin, paraffin embedding, and hematoxylin-eosin (H-E) dyes, and does histopathological examination, calculates each group model unit are inflammatory cell quantity.Collection of specimens, at duration of test, is weighed in weekly once.

Statistical procedures test data all adopts mean ± standard deviation to represent, group difference significance t inspection is compared, and P<0.05, for there being significant difference, adopts SPSS19.0 statistical software to carry out date processing.

4, experimental result: as shown in table 1.

Table 1 Eczema Model intradermal inflammatory cell count ratio comparatively

5, conclusion.

This experiment judges the curative effect of Chinese medicine composition of the present invention in eczema by the impact of the high, medium and low dosage of gained Chinese medicine composition ointment on mice inflammatory cell quantity in the research embodiment of the present invention 1.First, this experiment makes experimental animal with 60 mices, administration in continuous 15 days, and none is dead for mice, and put to death each internal organs of mice anatomic observation and do not find toxic reaction, Mouse Weight is also without significant change, and administration group and control group mice are without any difference.Wherein 50 mouse part skins are with after DNCB process, and local skin is coarse, thicken, lichenization, and pathological manifestations meets the symptom of Chronic dermatitis, and to be used for the treatment of eczema patients situation similar to Chinese medicine composition of the present invention, other 10 then as a control group.The remarkable increase (P<0.01) compared with Normal group of model group mice inflammatory cell amount, after DNCB process is described, mouse web portion cell produces inflammatory reaction, modeling success.The inflammatory cell amount of high dose group, middle dosage group, low dose group is compared with model group, and each group significantly can be reduced inflammatory cell amount (P<0.05), and wherein high dose group almost reaches levels found in normal controls.PIYANPING group treatment level is lower than the middle and high dosage group of Chinese medicine composition of the present invention, visible, three dosage groups of the embodiment of the present invention 1 Chinese medicine composition all can reduce the inflammatory cell amount of rat, especially better with middle high dose effect, and there is certain safety, there is the effect of good treatment chronic eczema.

test two: Chinese medicine composition of the present invention is to the clinical observation on the therapeutic effect of eczema clinical volunteers patient

One, case and diagnostic criteria

1, Western medicine diagnose standard:

Acute eczema: erythra pleomorphism, visible erythema, pimple, mound scar rash, water scar, erosion, scratch, knot are crazy about, are oozed out, and it is sick anxious, conscious scorching hot, violent pruritus.Erythra is often symmetrical, is common with places such as women's head-ornaments, distal limbs, scrotum, can general whole body, can develop into subacute eczema or chronic eczema, time light time heavy, repeatedly do not heal.

Subacute eczema: erythra is crazy about based on inflamed papules, squama, knot, has dark red or pale red patch, only has minority mound scar rash and erosion, or has mild infiltration, conscious pruritus.

2, tcm diagnosis standard:

With reference to " traditional Chinese medical science skin disease Standardization of diagnosis and curative effect " (State Administration of Traditional Chinese Medicine issues for 1994), " tcm syndrome Differential Diagnosis " (People's Health Publisher in " National Standard of the People's Republic of China's tcm clinical practice diagnosis and treatment term " (GB/T13.20), " People's Republic of China's traditional Chinese medicine industry standard ", in JIUYUE, 2002 version) meet the damp and hot pattern of syndrome of dermatosis: primary symptom: the acute course of disease or chronic course of disease acute attack, pruritus is heavier, ooze out obviously, companion's skin erythema, scorching hot.Secondary disease: vexed, thirsty, yellowish urine, large dry stool, red tongue, yellow and greasy fur, rolling pulse.Possess above primary symptom and secondary disease more than 2 persons, diagnosable is this syndrome.

Two, clinical trial

1, physical data

All selected eczema patients are clinical volunteers, do not comprise the patient that Zeng Quanshen in nearly 2 weeks uses glucocorticosteroid hormone or once used antihistaminic or external 17-hydroxy-11-dehydrocorticosterone preparation in 1 week, totally 300, the age is 20 years old-60 years old, 34.5 years old mean age, M-F is 1:1.Be divided into treatment group 150 and matched group 150 at random.Two groups of influence factors such as age, symptom, through statistical procedures, there was no significant difference, meets a point set condition.

2, Therapeutic Method

Treatment group: take gained Chinese medicine composition ointment in the embodiment of the present invention 3, smear 2 times on 1st, evaluate curative effect after being used in conjunction 15 days.

Matched group: (China Resources Sanjiu Medical & Pharmaceutical Co., Ltd. produces to use PIYANPING; The accurate word H44024170 of traditional Chinese medicines), within 1st, smear 2 times, after being used in conjunction 15 days, evaluate curative effect.

3, evaluation of clinical curative effect standard

1) curative effect determinate standard judges according to " new Chinese medicine guideline of clinical investigations ".

Scoring before therapeutic index=(before treatment scoring after scoring-treatment)/treatment

(1) clinical recovery: therapeutic index is 100%-95%;

(2) effective: therapeutic index is 60%-94%;

(3) effective: therapeutic index is 30%-59%;

(4) invalid: therapeutic index is 0-30%.

Total effective rate=(clinical recovery number of cases+effective number of cases+effectively number of cases)/(this organizes total number of cases × 100%).

2) pruritus scoring

0 point: without any pruritus.

1 point: pruritus once in a while, not medication, does not affect learning life.

2 points: paroxysmal pruritus, time light time heavy, affect sleep learning and lives, need medication.

3 points: violent pruritus, have a strong impact on work and study life.

4, therapeutic outcome, as shown in table 2.

Table 2 therapeutic effect

Group	Number of cases	Clinical recovery	Effective	Effectively	Invalid	Total effective rate
							Matched group	150	37	36	47	30	80%
Treatment group	150	59	48	31	12	92%

5, conclusion.

Shown by upper table 2 clinical laboratory data, also can find out from clinical cure rate, obvious effective rate and total effective rate, matched group total effective rate is 80%, and the total effective rate for the treatment of group is greater than 90%, far above the total effective rate of matched group.As can be seen here, the therapeutic effect of Chinese medicine composition of the present invention is better than PIYANPING, relative to Western medicine, has significant curative effect to treatment eczema, illustrates further the present invention and has advantage safely and effectively in treatment eczema, have broad application prospects.

Claims (7)

1. treat the Chinese medicine composition of eczema for one kind, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 6-20 part, Cortex Phellodendri 3-12 part, Fructus Kochiae 9-15 part, Radix Sophorae Flavescentis 3-12 part, Rhizoma Dioscoreae 3-10 part, Radix Astragali 3-10 part, Rhizoma Atractylodis 3-10 part, Poria 3-10 part, Radix Angelicae Pubescentis 3-8 part, Semen Plantaginis 3-8 part, Herba Pogostemonis 1-3 part and Radix Glycyrrhizae 1-12 part.

2. the Chinese medicine composition for the treatment of eczema as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 6 parts, Cortex Phellodendri 3 parts, the Fructus Kochiae 9 parts, Radix Sophorae Flavescentis 3 parts, Rhizoma Dioscoreae 3 parts, the Radix Astragali 3 parts, Rhizoma Atractylodis 3 parts, 3 parts, Poria, Radix Angelicae Pubescentis 3 parts, Semen Plantaginis 3 parts, Herba Pogostemonis 1 part and 5 parts, Radix Glycyrrhizae.

3. the Chinese medicine composition for the treatment of eczema as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 20 parts, Cortex Phellodendri 12 parts, the Fructus Kochiae 15 parts, Radix Sophorae Flavescentis 12 parts, Rhizoma Dioscoreae 10 parts, the Radix Astragali 10 parts, Rhizoma Atractylodis 10 parts, 10 parts, Poria, Radix Angelicae Pubescentis 8 parts, Semen Plantaginis 8 parts, Herba Pogostemonis 3 parts and 12 parts, Radix Glycyrrhizae.

4. the Chinese medicine composition for the treatment of eczema as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 12 parts, Cortex Phellodendri 9 parts, the Fructus Kochiae 12 parts, Radix Sophorae Flavescentis 6 parts, Rhizoma Dioscoreae 6 parts, the Radix Astragali 6 parts, Rhizoma Atractylodis 6 parts, 6 parts, Poria, Radix Angelicae Pubescentis 5 parts, Semen Plantaginis 5 parts, Herba Pogostemonis 2 parts and 10 parts, Radix Glycyrrhizae.

5. the Chinese medicine composition for the treatment of eczema as claimed in claim 1, it is characterized in that, described Chinese medicine composition is made into ointment, gel, ointment or cream.

6. the Chinese medicine composition for the treatment of eczema as claimed in claim 1, it is characterized in that, described Chinese medicine composition is obtained by following steps:

S1: get leaf of Moringa, clean, crushed after being dried becomes coarse powder, and cross 90-150 mesh sieve, adding described coarse powder total amount 6-10 times amount volume fraction is the ethanol of 60-75%, add the Snailase of coarse powder total amount 1.5%-3% again, lixiviate 2-5 hour at 38-45 DEG C, then at 80-90 DEG C of reflux, extract, 3-7 hour, filters, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract A;

S2: get Cortex Phellodendri, the Fructus Kochiae, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, the Radix Astragali, Rhizoma Atractylodis, Poria, Radix Angelicae Pubescentis, Semen Plantaginis, Herba Pogostemonis and Radix Glycyrrhizae, clean, crushed after being dried becomes coarse powder, adding described coarse powder gross weight 10-18 times amount volume fraction is the ethanol of 60-80%, microwave extraction 10-15 minute, and microwave power is 450-600W, Extracting temperature is 45-60 DEG C, filter and retain filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract B;

S3: extract A mixed with extract B, stirs, and continuing to be evaporated to relative density at 60 DEG C is the extractum of 1.30-1.35, to obtain final product.

7. the preparation method of the Chinese medicine composition of the treatment eczema as described in any one of claim 1-4, is characterized in that, comprise the following steps:

S1: get leaf of Moringa, clean, crushed after being dried becomes coarse powder, and cross 90-150 mesh sieve, adding described coarse powder total amount 6-10 times amount volume fraction is the ethanol of 60-75%, add the Snailase of coarse powder total amount 1.5%-3% again, lixiviate 2-5 hour at 38-45 DEG C, then at 80-90 DEG C of reflux, extract, 3-7 hour, filters, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract A;

S2: get Cortex Phellodendri, the Fructus Kochiae, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, the Radix Astragali, Rhizoma Atractylodis, Poria, Radix Angelicae Pubescentis, Semen Plantaginis, Herba Pogostemonis and Radix Glycyrrhizae, clean, crushed after being dried becomes coarse powder, adding described coarse powder gross weight 10-18 times amount volume fraction is the ethanol of 60-80%, microwave extraction 10-15 minute, and microwave power is 450-600W, Extracting temperature is 45-60 DEG C, filter and retain filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract B;

S3: extract A mixed with extract B, stirs, and continuing to be evaporated to relative density at 60 DEG C is the extractum of 1.30-1.35, to obtain final product.