CN104666468A - Pharmaceutical composition for treating hyperthyroidism and scrofula - Google Patents

Abstract

The invention discloses a pharmaceutical composition for treating hyperthyroidism and scrofula. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 4-8 parts of radix angelicae lateralis preparata, 1-5 parts of stir-baked squama manitis, 1-4 parts of gleditsia thorn, 1-3 parts of forsythia suspensa, 1-3 parts of frankincense, 1-3 parts of myrrh, 1-5 parts of pollen, 5-10 parts of bupleurum sinenses, 1-3 parts of scutellaria baicalensis, 1-3 parts of pachyrhizua angulatus, 1-3 parts of radix clematidis, 1-3 parts of sapanwood, 2-7 parts of notopterygium roots, 1-3 parts of radix angelicae, 2-5 parts of honeysuckle flowers, 1-3 parts of astragalus lithophilus, 1-5 parts of radix saposhnikoviae, 1-3 parts of concha haliotidis and 1-3 parts of liquorice. The pharmaceutical composition for treating hyperthyroidism and scrofula overcomes the defect of the existing medicine for treating hyperthyroidism and scrofula, and is good in effect.

Description

One treats hyperthyroidism, scrofulous pharmaceutical composition

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to one and treat hyperthyroidism, scrofulous pharmaceutical composition.

Background technology

Hyperthyroidism is called for short " hyperthyroidism ", is due to the too much thyroxin of thyroid synthesis release, causes the hyperfunction and sympathetic activation of organism metabolism, causes cardiopalmus, perspiration, feed and the just secondary disease increasing and lose weight.Most of patients also usually has the symptoms such as expophthalmos, blepharoedema, visual deterioration simultaneously.Thyroxin enhances metabolism, and promotes body redox reaction, and hypermetabolism needs body to increase feed; Gastrointestinal activity strengthens, and occurs just secondary increasing; Although feed increases, oxidation reaction strengthens, and human body energy consumption increases, and patients loses weight; Heat production increase performance To Be Protected from Heat perspire, there is low grade fever in few patients; Thyroxin increases stimulation sympathetic activation, clinical manifestation cardiopalmus, tachycardia, insomnia, responsive to surrounding, anxious state of mind, even anxiety.Hyperthyroidism disease is because comprising diffuse toxic goiter (also claiming Graves disease), and inflammatory hyperthyroidism (subacute thyroiditis, silent thyroiditis, postpartum thyroiditis and Hashitoxicosis), medicine cause hyperthyroidism (levothyroxine sodium and iodine cause hyperthyroidism), hCG dependency hyperthyroidism (the temporary hyperthyroidism of vomiting during pregnancy) and the hyperthyroidism of TSH of pituitary tumor.Hyperthyroid patient does not obtain appropriate therapeutic for a long time, can cause and become thin and hyperthyroid heart disease.Patient becomes thin and usually easily suffers from acute infectious disease and infect and to disable or dead.Hyperthyroid heart disease causes cardiac dilatation, arrhythmia, atrial fibrillation and heart failure, patient disability, even dead.

At present, Treatment of Hyperthyroidism has three kinds of methods, Anti-thyroid Medicine, radioiodine therapy and operative treatments.1, Anti-thyroid Medicine wide accommodation, no matter child adult, male or women, mild or serious symptom hyperthyroidism, First episode or hyperthyroidism recurrence, anemia of pregnant woman or lactating female hyperthyroidism can use Drug therapy.Antithyroid drug has two kinds---and imidazoles and thiouracil class, represent medicine and be respectively thiamazole (also known as " thiamazole ") and propylthiouracil (also known as " third is phonetic ").2, Drug therapy is applicable to the patient of Hyperthyroidism Mothers, child, thyroid silght enlargement, and treatment generally needs 1-2, needs according to thyroid function situation increase and decrease drug dose in treatment.Drug therapy has some side effect, comprise granulocytopenia, drug allergy, liver function damage, arthralgia and vasculitis, the Drug therapy initial stage needs tightly to monitor side effects of pharmaceutical drugs, especially agranulocytosis, need to warn patient once there is heating and/or pharyngalgia, need to check granulocyte immediately clearly whether there is agranulocytosis, once occur.Drug withdrawal emergency treatment immediately.Another shortcoming of Drug therapy is that after drug withdrawal, relapse rate is high, greatly about about 50%.3, radioiodine therapy and operative treatment all belong to destructive treatment, and hyperthyroidism is not easy recurrence, and treatment only needs once.Radioiodine is applicable to the patient of thyroid moderate swelling or hyperthyroidism recurrence, and doctor calculates the radiological dose of each needs of patients according to the uptake ratio of patient's thyroid to radioiodine.Radioiodine is absolute contraindication to anemia of pregnant woman and nursing women.Effect due to radioiodine has a delay action, along with the time is with examining, and the annual 3-5% of hypothyroidism incidence rate.Radioiodine therapy is not suitable for the hyperthyroid patient of thyroid eye diseas, because oculopathy may be aggravated after treatment.That operative treatment is applicable to those thyromegaly is remarkable, or strong suspicion thyroid malignancy, or thyromegaly has the tracheas suppressed person that causes dyspnea.Operation consent needs to control in normal range with medicine by thyroid function, and the preoperative oral administered compound iodine solution that also needs does Preoperative Method.

Lymphoid tuberculosis, the traditional Chinese medical science is referred to as scrofula, is the malicious block organization being embodied in flesh table, is to be condensed into by the scorchingly hot poison of expectorant of liver lung two aspect.Doctor trained in Western medicine then refers to, specializes in detoxicating virus killing thus protection blood vessel, the lymphsystem of tissue, meets with ex vivo and cannot remove the toadstool killed, condense and assemble the malignant tumor formed in flesh table organization in human body.How to grow pimple in cervical region side or bilateral, grow up gradually, superficial, push slip, without obvious tenderness, as passive protective physical fitness is low, increase gradually, skin sends out purpling, and final ulceration flowing water sample pus also discharges the cheesy pus of yellow turbid sample, and the traditional Chinese medical science is referred to as to call " lymphoid tuberculosis ".Systemic toxicity profiles symptoms such as repeatedly festering few, some patients can have low grade fever, robber, antiperspirant inappetence, become thin.

Tuberculous lymphadenitis pathogenic factor has two kinds: a kind of is that tubercule bacillus infects on oral cavity and the nasopharynx part primary tumor that especially tonsil gland causes by upper respiratory tract or with food.Tailing edge lymphatic vessel arrives the shallow deep layer lymph node of cervical region.Each position mostly is Unilateral lymph node.Get involved pharyngeal.After retransmitting sick above absorption, involved lymph nodes core still continues development and forms cold abscess or ulcer.Another kind is that after primary tuberculosis infects, in blood, tubercule bacillus enters inside neck lymph node with blood, causes the tuberculosis of cervical lymph nodes; Can also infect from waist and belly lymph, then draw and deep lymph node group secondary infection, comparatively common in lymphoid tuberculosis morbidity.

At present, treatment lymphoid tuberculosis, generally adopts western medical treatment: 1, whole body therapeutic, suitably notes nutrition and rest.Oral isoniazid 1-2, with systemic toxic symptoms or the health elsewhere person that has tuberculosis.Add sodium aminosalicylate or rifampicin or add and use streptomycin intramuscular injection.2, topical therapeutic: 1) minority is limited to, and larger, the lymph node that can promote, can consider excision.Note during operation not damaging accessory nerve; 2) form cold abscess and not yet do not wear out person, pus is taken out in feasible undermining puncture.From the normal skin inserting needle around abscess.Take out most pus as far as possible, then inject in vomica 5% different cigarette wink solution or 10% Streptomycin Solution rinse.And stay appropriate in vomica, 2 times weekly; 3) cold abscess ulceration forms ulcer or sinus tract person, as secondary infection is not obvious, feasiblely to draw together except art.Carefully knot school pathological tissues is all drawn together and remove.Wound does not add stitching, changes dressings with Streptomycin Solution; 4) cold abscess secondary pyogenic infection person.Need leading incision and drainage, after infection control, row curettage more if desired.

In prior art, all come with some shortcomings for treatment hyperthyroidism, scrofulous medicine or method, the traditional Chinese medical science is of extensive knowledge and profound scholarship, and Study of Traditional Chinese Medicine treats hyperthyroidism, lymphoid tuberculosis is necessary.

Summary of the invention

The technical problem to be solved in the present invention is the deficiency overcoming existing treatment hyperthyroidism, lymphoid tuberculosis medicine, provides one to treat hyperthyroidism, the good pharmaceutical composition of lymphoid tuberculosis effect.

In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summary, is made up of the raw material of following weight parts:

Preferably, be made up by weight of following raw materials according:

The dosage form of pharmaceutical composition of the present invention can be the medically acceptable dosage form such as capsule, pill, tablet, decoction, medicated wine, and their preparation method, supplementary product consumption are undertaken by existing common process, preferred medicated wine.

The present invention also comprises the application of aforementioned pharmaceutical compositions in preparation treatment hyperthyroidism, scrofulous medicine.

The traditional Chinese medical science is thought, many being pented up through wind heat gas poison by three Jiao, liver, gallbladder etc. of scrofula incidence forms, and Liver and kidney two, through deficiency of both QI and blood, caused by dynamic in asthenic fire, can be divided into acute, chronic two classes.Acute many because of affection due to external wind and heat, in accumulate expectorant poison and send out; Because the stagnation of QI, void are hindered and sent out more than chronic.This disease is often enraged angry strongly fragrant, and it is unsuccessful to consider, and spirit is downcast.

In the present invention:

Radix Angelicae Sinensis, the supporting root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Another name: Radix Angelicae Sinensis, Radix Angelicae Sinensis, return and must, return lower limb, slightly return lower limb.Profile, Radix Angelicae Sinensis root is slightly cylindrical, and root upper end claims " returning head ", and main root claims " returning body " or " very little body ". and supporting root claims " Radix Angelicae Sinensis " or " returning lower limb ", all titles " Radix Angelicae Sinensis ".Effectiveness: Radix Angelicae Sinensis is enriched blood and invigorated blood circulation, Radix Angelicae Sinensis body is enriched blood, and Radix Angelicae Sinensis is invigorated blood circulation.Meridian distribution of property and flavor: pungent, sweet, warm.Cure mainly: promoting blood circulation and breaking stagnation, menstruction regulating and pain relieving.Control menoxenia, dysmenorrhea, stomachache, traumatic injury, skin infection.

Stir-baked SQUAMA MANITIS, another name: big gun first first sheet hard first (Squama Manis) sheet, latin name: Squama Manitis former animal Manis pentadactyla L. English name: medical material Pangolin Scales, source: be the scute of Manidae animal Manitis.Effect: the routed carbuncle of detumescence, searches wind active, stimulating milk secretion of stimulating the menstrual flow.Cure mainly: control carbuncle skin ulcer and swell, anemofrigid-damp arthralgia, amenorrhea, galactostasis, has blood in stool.Meridian distribution of property and flavor: salty is cool.1. " not Lu ": " be slightly cold." 2. " property of medicine opinion ": " very toxic." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " and cold, salty in the mouth." enter liver, stomach warp.1. " detailed outline ": " enter to faint the bright warp of yin, yang." 2. " book on Chinese herbal medicine converges and says ": " enter lunar, the JUE YIN meridian of foot.”

Fructus Gleditsia acupuncture, has another name called Spina Gleditsiae, is the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..There is detumescence poison holding, evacuation of pus, effect of parasite killing.Be usually used in carbuncle from the beginning of or difficulty in discharging of pus; External treatment scabies leprosy.

Lian Zhao, has another name called Fructus Forsythiae, nature and flavor: bitter, cool.1. " herbal classic ": bitter in the mouth, flat.2. " not Lu ": nontoxic.3. " medicine origin ": " curing mainly secret formula " cloud, cool in nature, bitter in the mouth.4. " detailed outline ": micro-toil.Gui Jing: enter the heart, liver, gallbladder meridian.Function cures mainly: heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.1. " herbal classic ": main cold and heat, Mus flaccidity, scrofula, carbuncle malignant boil, goiter, stagnation of pathogenic heat.2. " not Lu ": remove tapeworm.3. " property of medicine opinion ": main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat.4. " Japan hanako materia medica ": logical small intestinal, evacuation of pus.Control furuncle, pain relieving, logical menstruation.5. Li Gao: loose all menses stagnation of QI gather; Detumescence.6. Wang Haogu: control deaf Hun Hun Jun Jun.

Olibanum is the resin that olive subject plant Boswellia carterii Boswellia carterii Birdw. and congener Boswellia bhaurdajiana Birdw. bark ooze out.Nature and flavor: pungent, bitter, temperature.Gui Jing: GUIXIN, liver, spleen channel.Effect: blood-activating and qi-promoting pain relieving, detumescence and promoting granulation.Cure mainly: for obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation, lump in the abdomen is suffered from abdominal pain, rheumatic arthralgia, the contracture of muscle arteries and veins, traumatic injury, carbuncle skin infection.

Myrrha (Commiphora myrrha Eng1.), has another name called myrrh, is olive subject plant Herba Violae tree or the dry resin of Ha Didingshu.Main product is in African Somalia, Ethiopia and India and other places.Gather the white oleo-gum-resin of being oozed out by bark crack, in air, become rufous and hard nahlock.After smashing, fry to coke black and apply.Cure mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.There is the effect such as promoting blood circulation and stopping pain, detumescence and promoting granulation.

Pollen, can nervous system regulation, hypnotic, health invigorating; Improve gastrointestinal function, facilitating digestion, appetite strengthening, control habitual constipation; Hepatoprotective, prevents and treats anemia, diabetes, prostate hyperplasia, cardiovascular and cerebrovascular disease; Endocrine regulation, improves body function; Treatment chronic bronchitis and mucosa disease etc.

Radix Bupleuri, another name: Asia puecon Hu, Radix Bupleuri, hard Radix Bupleuri, latin name: Bupleurumchinense, section's name: Umbelliferae, generic name: Bupleurum, morphological characteristic: root manure is thick, coniform.Stem is upright, bending in "the" shape.Leaf alternate, wire lanceolar or drape over one's shoulders pin Long Circle, the long point of tip.Umbel.Spend little, yellow.Fruit ellipticity is avette.The florescence 7-8 month.Adaptable area: originate in China, be mainly distributed in the provinces such as Jilin, Liaoning, Hebei, Henan, Shandong.Also there are distribution in Korea, Japan, the Soviet Union.Habit: Chang Yesheng is unoccupied place, thick grass and roadside in drier hillside, border, woods.Like warm, moistening.Cold-resistant, drought-enduring.Water funk leaching.Well-grown in sandy loam or leaf mould, on saline-alkali soil, Failure to thrive is contained, and crispaturaing easily appears in blade.Medical value: root, stem are used as medicine, name Radix Bupleuri, can induce sweat and inner, yang invigorating, dispersing the stagnated live-QI to relieve the stagnation of QI.Be used as medicine with root.Property bitter, be slightly cold, to liver, lung have induce sweat and in, the regulating menoxenia of yang invigorating, the soothing the liver solution stasis of blood.Cure mainly flu, upper respiratory tract infection, malaria, alternate attack of chill and fever, costalgia, hepatitis, biliary tract infection, cholecystitis, menstruation are not withered, proctoptosis.

Radix Scutellariae (Classification system: Scutellaria baicalensis Georgi), another name Radix Scutellariae, tsuchikane tea root are Labiatae Scutellaria herbaceos perennials.The root of Radix Scutellariae is used as medicine, bitter in the mouth, cold in nature, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical antibiotic property of Radix Scutellariae is better than Rhizoma Coptidis, and does not develop immunity to drugs.

Pachyrhizua angulatus is pulse family, the mutation (Classification system: Pueraria lobata (Willd.) Ohwi var.thomsonii (Benth.) Vaniot der Maesen) of Pueraria Pueraria lobota, cure mainly fever caused by exogenous pathogens, rigidity pain on the head and nape, measles from the beginning of, rash go out smooth, epidemic febrile disease is thirsty, quench one's thirst, have loose bowels, dysentery, hypertension, coronary heart disease.

Radix Clematidis, expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Detoxicating and resolving stagnation of pathogens.

Lignum Sappan is the dry duramen of Caesalpiniaceae Caesalpinia plant Lignum Sappan.Nature and flavor: sweet; Salty; Xin Liang.Gui Jing: the heart; Liver; Stomach; Spleen channel.Drug effect: blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.As married woman's amenorrhea due to stagnation of blood, dysmenorrhea, postpartum stagnation cardiac and abdominal pain, puerperal blood faints, carbuncle, traumatic injury, tetanus.

Rhizoma Et Radix Notopterygii, another name Qiang is blue or green, protect Qiang envoy, recklessly king envoy, Qiang is sliding, move back wind envoy, black powder, Latin literary fame Notopterygium incisum. Umbelliferae, Notopterygium plant, perennial herb, high 60-120 centimetre, and rhizome is sturdy, extends in Bamboo-shaped.There is withered sheath in collar portion.Stem is upright, and cylindrical, hollow, has vertical straight stria, band purple.Chinese medicine cures mainly: warm in nature, dispelling cold and dampness, for affection of exogenous wind-cold, have a headache lossless, cold-damp numbness, upper limb rheumatalgia.

The Radix Angelicae Dahuricae, Latin literary fame: Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.ex Franch.et Sav, perennial tall and big draft, high 1-2.5 rice, root is cylindrical, basal part of stem footpath 2-5 centimetre, a basal leaf pinnation, universal umbel top is raw or side is raw, and fruit Long Circle is to oval.Be used as medicine with root, the functions such as the dehumidifying that gets rid of illness, evacuation of pus granulation promoting, promoting blood circulation and stopping pain.Cure mainly anemofrigid cold, headache, rhinitis, toothache.The diseases such as leucorrhea with red and white discharge, pain furuncle and phyma poison, also can make spice.

Flos Lonicerae, have another name called Radix Ophiopogonis, Flos Lonicerae, Flos Lonicerae etc., cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the cards such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.Effect is summarized: heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, warm blood fulminant dysentery, anemopyretic cold, epidemic febrile disease is generated heat.Modern study proves, Flos Lonicerae contains the pharmacological component such as chlorogenic acid, luteolin glycosides, stronger restraint is had to the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc., in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary, hypertension etc. more than 40 with other medicines compatibility and plant disease.

Raw over sixty years of age, having another name called Radix Astragali, is the root of leguminous plant Radix Astagali or Radix Astragali.Main product is in the Inner Mongol of China, Shanxi, Heilungkiang and other places.Spring and autumn is excavated, and removing several, fibrous root head, dries, section, raw use.The root of the Radix Astragali is famous Chinese medicine.Genus Astragalus of Local Used Commercial Huang is cylindrical, slightly distortion, long 20-60 centimetre, with bar slightly long, wrinkle is few, matter is hard and continuous, mealiness foot, the sweet person of taste as well.Containing coumarin, flavone compound, Saponin and micro-folic acid and several vitamin etc.Sweet in the mouth, tepor, has invigorating QI to consolidate the body surface resistance, and effect of holder skin ulcer granulation promoting, diuretic, cures mainly the diseases such as deficient qi and blood, spontaneous perspiration, chronic diarrhea proctoptosis, uterine prolapse, nephritis edema, albuminuria, diabetes, chronic ulcer.Clinical treatment hypertension and the acute and chronic nephritis of being used for.

Radix Saposhnikoviae, another name copper rues, Hui Yun, return grass, Rhizoma Cibotii, hundred kinds, herbaceos perennial, the nice and cool weather of its happiness, resists cold, drought-resistant, main product in Hebei, Heilungkiang, Sichuan, the ground such as Inner Mongol.The Gen Kesheng of Radix Saposhnikoviae uses.Acrid in the mouth, sweet, slightly warm in nature.There is expelling pathogenic wind from the body surface, removing dampness to relieve pain, effect of relieving convulsion.

Concha Haliotidis is the shell of Bao Ke animal Haliotis diversicolor, haliotis discus hannai Ino, ear Bao, sheep Bao etc.Have another name called natural pearls mother (Lei Gong's Treatise on Preparation and Broiling of Materia Medica), Carnis Haliotidis first (Collective Notes to the Canon of Materia medica), nine hole spiral shells (" Japan hanako materia medica "), Herba Senecionis Scandentis (" detailed outline "), very sea certainly, extra large Semen Cassiae, CONCHA HALIOTIDI, abalone shells, nine hole Concha Haliotidis (" pharmacognosy "), Carnis Haliotidis skin (" Shandong Chinese medicine handbook "), golden Carnis Mactrae skin (" Shandong Chinese herbal medicine ").There is calming liver and clearing heat, effect of improving eyesight removing nebula.

Radix Glycyrrhizae, has another name called Herba Hedyotis cantonensis root, Radix Glycyrrhizae, Radix Glycyrrhizae, Radix Glycyrrhizae, and be a kind of tonification Chinese herbal medicine, medicinal part is root and rhizome, and Medicinal Materials Characters root is cylindrical, long 25-100cm, diameter 0.6-3.5cm.Crust degree of tightness differs, the brown or taupe brown of surface red.Rhizome is cylindrical, and there is bud trace on surface, has marrow in the middle part of section.Feeble QI, taste is sweet and special.Nature and flavor: sweet are flat.Gui Jing: GUIXIN warp, lung meridian, spleen channel, stomach warp.Function: QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.Cure mainly: cure mainly deficiency-weakness of spleen-QI, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, pathopyretic ulcer, laryngopharynx swelling and pain, medicine, alimentary toxicosis; Mitigation medicine is strong, toxicity.

In present composition side, pollen, Lian Zhao, Fructus Gleditsia acupuncture, Olibanum, life energy over sixty years of age YIN nourishing and the production of body fluid promoting, help and reduce phlegm with clearing away heat-fire with Radix Angelicae Sinensis, Squama Manis, Radix Scutellariae, north Hu, Flos Lonicerae etc., assistant with Lignum Sappan, Concha Haliotidis, Radix Saposhnikoviae with removing liver heat and toxic substances, be beneficial to improving eyesight, all medicines share, both can replenishing YIN and removing heat, again can dissipating phlegm and resolving masses, the property of medicine is regulated with Radix Glycyrrhizae, adjustable with drug effect with wine, the effect of reinforcement and elimination in combination, YIN and YANG balance regulating can be played.

Detailed description of the invention

With specific embodiment, the invention will be further described below, but the present invention is not limited to these embodiments.

Embodiment 1

Take above each raw material by proportional quantity, decoct with water twice, first time adds 7 times of water gagings, decoct 1.5 hours, second time adds 8 times of water gagings, decocts 1.5 hours, collecting decoction, filter, filtrate is concentrated into the extractum that relative density is 1.30 (surveying when 70 DEG C), adds the dextrin adjuvant of conventional amount used, technique routinely, make capsule, 0.5g/ grain.

Embodiment 2

Above each raw material is taken by proportional quantity, decoct with water twice, first time adds 7 times of water gagings, decocts 1.5 hours, and second time adds 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, and filtrate is concentrated into the extractum that relative density is 1.30 (surveying when 70 DEG C), add appropriate cane sugar powder, technique makes granule routinely.

Embodiment 3

Take above each raw material, the wine adding same weight decocts, and obtains 10 doses.

Experimental example: the embodiment of the present invention 3 treats hyperthyroidism, lymphoid tuberculosis clinical observation on the therapeutic effect:

One, hyperthyroidism clinical data is treated:

Case selection: fetch the 72 routine hyperthyroid patients coming from the court outpatient, male 32 people, female 40 people; Age 23-44 year, average 30.5 years old.72 routine patients are divided into treatment by Chinese herbs group and western medicine group at random, treatment by Chinese herbs group 36 people, male 12 people, female 20 people; Western medicine group 36 people, male 12 people, female 20 people.

Diagnostic criteria: according to " internal medicine " the 7th edition teaching material.Have hypermetabolism sings and symptoms, thyromegaly, thyroid function checks that serum T T4, FT4, TT3, FT3 increase and TSH lowers.Or have stickiness edema before exophthalmos, shin.

Therapeutic Method:

Treatment by Chinese herbs group: take medicated wine prepared by the embodiment of the present invention 3, every day 1 dose 10 days is 1 course for the treatment of.

Western medicine group: oral thiamazole sheet, every day 3 times, each 2 30 days is 1 course for the treatment of.

The standard of curative effect evaluation:

Recovery from illness: a. transference cure, body weight increases, and pulse frequency is normal, and region thyreoidea trembles and vascular murmur disappears, and goiter and exophthalmos alleviate; B. serum T 3, T4, FT4 level is normal, thyroid tablet or the T3 inhibition test positive (can suppress), and thyroid immunologic test is normal;

Effective: a. symptom takes a turn for the better, and pulse frequency slows down, and goiter is reduced, and vascular murmur alleviates; B. serum T 4, T3, FT4 level is normal, and thyroid tablet or T3 inhibition test feminine gender (can not suppress), still need continual cure.

Invalid: a. symptom is without improvement, and pulse frequency change is little, goiter is almost without reducing or becoming large, and vascular murmur is without alleviating; B. serum T 4, T3, FT4 level is still abnormal, thyroid tablet or T3 inhibition test feminine gender (can not suppress).

Therapeutic outcome:

Table 1 liang group Clinical efficacy comparison

	Number of cases	Recovery from illness	Effectively	Invalid	Effective percentage
						Treatment group	36	24	8	0	100％
Matched group	36	6	22	8	77.78％

As can be seen from Table 1, adopt treatment by Chinese herbs hyperthyroidism of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement.Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Clinical Follow-up is without recurrence.

Two, lymphoid tuberculosis clinical data is treated:

Case selection: fetch the 48 routine hyperthyroid patients coming from the court outpatient, male 14 people, female 34 people; Age 13-32 year, average 28.6 years old.

Take medicated wine prepared by the embodiment of the present invention 3, every day 1 dose 10 days is 1 course for the treatment of.

Criterion of therapeutical effect:

Recovery from illness: transference cure;

Effective: symptom makes moderate progress, focus is improved substantially;

Invalid: without significant change or deterioration before and after treatment.

Therapeutic effect statistics is as follows:

	Number of cases	Recovery from illness	Effectively	Invalid	Effective percentage
						Treatment group	48	35	13	0	100％

The effect that prescription of the present invention has short treating period for treatment hyperthyroidism, lymphoid tuberculosis, effects a radical cure, has no side effect.

Claims (3)

1. treat hyperthyroidism, a scrofulous pharmaceutical composition, it is characterized in that: this pharmaceutical composition is made up of the raw material of following weight parts:

2. treatment hyperthyroidism according to claim 1, scrofulous pharmaceutical composition, is characterized in that: this pharmaceutical composition is made up of the raw material of following weight parts:

3. the application of the pharmaceutical composition according to any one of claim 1-2 in preparation treatment hyperthyroidism, scrofulous medicine.