CN108542933A - A kind of antibacterial anti-inflammatory Chinese medicine composition and preparation method thereof - Google Patents
A kind of antibacterial anti-inflammatory Chinese medicine composition and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to technical field of traditional Chinese medicine preparation more particularly to a kind of antibacterial anti-inflammatory Chinese medicine composition and preparation method thereof.The Chinese medicine composition is mainly prepared by following raw material in parts by weight：0.8~1.2 part of Prunella vulgaris, 0.8~1.2 part of radix scutellariae, 1.8~2.2 parts of honeysuckle, 0.8~1.2 part of the root of Dahurain angelica, 0.4~0.6 part of asarum, 0.4~0.6 part of Radix Astragali, 0.4~0.6 part of safflower.Using Prunella vulgaris as monarch drug in a prescription, using radix scutellariae and honeysuckle as ministerial drug, using the root of Dahurain angelica, asarum and safflower as adjutant, each raw material collaboration compatibility plays clearing away the liver-fire, relieving heat toxin, dissipates the effect of phlegm knot, righting gas altogether, has significant antibacterial and antiinflammation.Chinese medicine composition of the present invention can be prepared into liquid formulation, and can take orally to take outside, with to scrofula with significant therapeutic effect, while to other chronic inflammation diseases have therapeutic effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation more particularly to a kind of antibacterial anti-inflammatory Chinese medicine composition and its preparation sides
Method.
Background technology
Tuberculosis is by combining caused by bacillus intrusion human body, many positions of human body can be invaded, such as lung, bone, leaching
It fawns on, intestines etc., is most with pulmonary tuberculosis, be most obstinate with scrofula.Scrofula accounts for about lungy 17.5%.Human body supports
Drag reduction is an important factor for causing lymph to combine.Lymph combine be mainly under neck, oxter, jaw, groin etc., part
Knot swollen hard such as core, innumerable bunchiness, sometimes diabrosis are suppurated.Currently, doctor trained in Western medicine not yet develops the special medicament that treatment lymph combines, control
Generally using phthisical therapeutic regimen is treated in treatment, such as：Rimifon, rifampin, ethambutol, intramuscular injection streptomysin etc..These
Antituberculotic is mostly relatively low because of lesion local blood concentration, can not achieve effective Antibacteria effect, or make to control because of adverse reaction
Treat failure.Moreover, treating tuberculosis Western medicine toxic side effect is larger, take for a long time, easily causes the diseases such as hepatopathy, deafness, optic neuritis.Lesion is clear
Except art coordinates antituberculosis drugs treat, though curative effect can be improved, preoperative and postoperative administration time is long, and total course for the treatment of is longer.And inevitably
The hardship operated on easily stays scar to influence beauty.Scrofula drug resistance is strong, and high recurrence rate, treatment cycle is long, is there is no at present for leaching
Bar tuberculosis disease special medicament, the multi-purpose phthisical medicine control scrofula for the treatment of of doctor trained in Western medicine, curative effect are not ideal enough.Therefore, it drenches
It fawns on core and is referred to as worldwide persistent ailment.
In order to overcome the scrofulous defect of western medical treatment, the medicine researched and developed based on theory of traditional Chinese medical science has also been gradually appeared in recent years
Object.Chinese medicine thinks, scrofulous morbidity and physically weak, cult poison, phlegm knot, the obstruction of the circulation of vital energy, blood stasis, weakened body resistance related.The obstruction of the circulation of vital energy and it is physically weak be interior
Cause, i.e. liver disorder.Cult poison is external factor, is a kind of pathogenic external perverse trend, and phlegm knot is a kind of pathological product.Therefore it is right
Think the method that should impose dissipating phlegm and removing blood stasis, softening and resolving hard mass or nourishing Yin and clearing heat, QI invigorating righting in scrofulous treatment Chinese medicine.Example
If Chinese patent CN101721494A discloses a kind of Chinese medicine for treating lymphonodi cervicales conjunction, by folium isatidis, cottonrose hibiscus leaf, Pu Gong
English, honeysuckle, Chinese holly leaf, radix semiaquilegiae and Prunella vulgaris are prepared, and are generated centainly although the drug can close lymphonodi cervicales
Therapeutic effect, but the preparation method of selection and the use due to its prescription raw material so that the active ingredient of each raw material cannot
What is obtained adequately extracts and is absorbed and utilized, and therapeutic effect still cannot meet the treatment need clinically closed to lymphonodi cervicales
It asks, it is still desirable to the formula and preparation method of Chinese medicine are improved, the therapeutic effect of drug is improved.
Invention content
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of antibacterial anti-inflammatory Chinese traditional medicine compositions
Object, each bulk pharmaceutical chemicals reasonable compatibility have strong antibacterial and anti-inflammatory effect, are combined to lymph and what various chronic inflammations had had controls
Therapeutic effect.
The second object of the present invention is to provide a kind of preparation method of antibacterial anti-inflammatory Chinese medicine composition, carry to greatest extent
The active ingredient in each bulk pharmaceutical chemicals is taken out, curative effect of medication is improved.
To achieve the goals above, realization is adopted the following technical scheme that：
A kind of antibacterial anti-inflammatory Chinese medicine composition, is mainly prepared by following raw material in parts by weight：Prunella vulgaris 0.8~
1.2 parts, 0.8~1.2 part of radix scutellariae, 1.8~2.2 parts of honeysuckle, 0.8~1.2 part of the root of Dahurain angelica, 0.4~0.6 part of asarum, Radix Astragali 0.4~
0.6 part, 0.4~0.6 part of safflower.
A kind of antibacterial anti-inflammatory Chinese medicine composition, is mainly prepared by following raw material in parts by weight：1 part of Prunella vulgaris, Huang
1 part of a kind of reed mentioned in ancient books, 2 parts of honeysuckle, 1 part of the root of Dahurain angelica, 0.5 part of asarum, 0.5 part of Radix Astragali, 0.5 part of safflower.
Optionally, the dosage form of the Chinese medicine composition is liquid formulation.
The preparation method of above-mentioned antibacterial anti-inflammatory Chinese medicine composition, including following operating procedure：
1) each bulk pharmaceutical chemicals are weighed in parts by weight, and the concentration of alcohol that 3~4 times of amounts of each bulk pharmaceutical chemicals total weight are added is 60%
Edible alcohol impregnates 49 days under room temperature, filters off solid drugs, obtains liquid filtrate；
2) liquid filtrate prepared by step 1) is subjected to distillation processing, and recycles the ethyl alcohol distilled out；
3) water is added in step 2) distillation treated liquid filtrate and is diluted processing to required concentration, i.e., it is complete
At.
Optionally, the liquid filtrate prepared to step 1) in step 2) carries out distillation processing to concentration of alcohol in liquid filtrate
Less than 20%.
Optionally, the volume ratio of addition Yu step 2) distillation treated the liquid filtrate of water is 1 in step 3)：6.
Optionally, each bulk pharmaceutical chemicals are pre-processed before edible alcohol being added in step 1), pretreated specific side
Method is：It is 1~3mm that particle size is crushed to after each bulk pharmaceutical chemicals are mixed.
Antibacterial anti-inflammatory Chinese medicine composition of the present invention, the type and dosage of creative selection bulk pharmaceutical chemicals, are monarch with Prunella vulgaris
Medicine, using radix scutellariae and honeysuckle as ministerial drug, using the root of Dahurain angelica, asarum and safflower as adjutant,.Each raw material collaboration compatibility plays clearing away the liver-fire, solution altogether
Heat toxin dissipates the effect of phlegm knot, righting gas, has significant antibacterial and antiinflammation.Chinese medicine composition of the present invention can be prepared into
Liquid formulation, can take orally to take outside, with to scrofula with significant therapeutic effect, while to other chronic inflammations
Disease property disease has therapeutic effect.
Chinese medicine composition of the present invention can be prepared into liquid formulation, and liquid formulation present invention basis in preparation process is each
The characteristic and compatibility relationship of bulk pharmaceutical chemicals, creative selects concentration of alcohol to carry out immersion treatment for 50% edible alcohol, and
The suitable amounts for limiting edible alcohol, extract the active ingredient in bulk pharmaceutical chemicals, and in soaking process to greatest extent
Synergistic effect is played between the active ingredient of each raw material and especially promotes the extraction of monarch drug in a prescription and ministerial drug active ingredient, and then is improved entire
The curative effect of medication of Chinese medicine liquid formulation.
Specific implementation mode
In the following, in conjunction with specific implementation mode, the present invention is described further, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
The dosage form of following Chinese medicine compositions is liquid formulation
Embodiment 1
A kind of antibacterial anti-inflammatory Chinese medicine composition, is prepared by following raw material in parts by weight：1 part of Prunella vulgaris, radix scutellariae 1
Part, 2 parts of honeysuckle, 1 part of the root of Dahurain angelica, 0.5 part of asarum, 0.5 part of Radix Astragali, 0.5 part of safflower.
The preparation method of above-mentioned antibacterial anti-inflammatory Chinese medicine composition, including following operating procedure：
1) each bulk pharmaceutical chemicals are weighed in parts by weight, and it is 1~3mm to be crushed to grain size, and 3 times of amounts of each bulk pharmaceutical chemicals total weight are added
The edible alcohol that concentration of alcohol is 60% impregnates 49 days under room temperature, and elimination solid drugs obtain liquid filtrate；
2) liquid filtrate prepared by step 1) is subjected to distillation processing to the concentration of alcohol near 20% in liquid filtrate, and
Recycle the ethyl alcohol distilled out；
3) water that 6 times of amounts are added in step 2) distillation treated liquid filtrate are diluted processing to required dense
Degree, that is, complete.
Embodiment 2
A kind of antibacterial anti-inflammatory Chinese medicine composition, is mainly prepared by following raw material in parts by weight：0.8 part of Prunella vulgaris,
0.8 part of radix scutellariae, 1.8 parts of honeysuckle, 0.8 part of the root of Dahurain angelica, 0.4 part of asarum, 0.4 part of Radix Astragali, 0.4 part of safflower.
The preparation method of above-mentioned antibacterial anti-inflammatory Chinese medicine composition, including following operating procedure：
1) each bulk pharmaceutical chemicals are weighed in parts by weight, and it is 1~3mm to be crushed to grain size, and 3 times of amounts of each bulk pharmaceutical chemicals total weight are added
The edible alcohol that concentration of alcohol is 60% impregnates 49 days under room temperature, and elimination solid drugs obtain liquid filtrate；
2) liquid filtrate prepared by step 1) is subjected to distillation processing to the concentration of alcohol near 20% in liquid filtrate, and
Recycle the ethyl alcohol distilled out；
3) water that 6 times of amounts are added in step 2) distillation treated liquid filtrate are diluted processing to required dense
Degree, that is, complete.
Embodiment 3
A kind of antibacterial anti-inflammatory Chinese medicine composition, is mainly prepared by following raw material in parts by weight：1.2 parts of Prunella vulgaris,
1.2 parts of radix scutellariae, 2.2 parts of honeysuckle, 1.2 parts of the root of Dahurain angelica, 0.6 part of asarum, 0.6 part of Radix Astragali, 0.6 part of safflower.
The preparation method of above-mentioned antibacterial anti-inflammatory Chinese medicine composition, including following operating procedure：
1) each bulk pharmaceutical chemicals are weighed in parts by weight, and it is 1~3mm to be crushed to grain size, and 4 times of amounts of each bulk pharmaceutical chemicals total weight are added
The edible alcohol that concentration of alcohol is 50% impregnates 49 days under room temperature, and elimination solid drugs obtain liquid filtrate；
2) liquid filtrate prepared by step 1) is subjected to distillation processing to the concentration of alcohol near 20% in liquid filtrate, and
Recycle the ethyl alcohol distilled out；
3) water that 6 times of amounts are added in step 2) distillation treated liquid filtrate are diluted processing to required dense
Degree, that is, complete.
Performance detection：
Chinese medicine liquid formulation prepared by the pharmacodynamics test verification embodiment of the present invention 1~3, which has, significantly improves immune effect,
Inhibit to combine bacillus effect with significant.Acute toxicity test shows that Chinese medicine liquid formulation of the present invention is nontoxic, and three cause experiment table
Bright liquid formulation of the present invention is without carcinogenic, teratogenesis, mutagenesis.
Comparative example 1
This comparative example Chinese medicine liquid formulation is prepared by following raw material in parts by weight：40 parts of folium isatidis, cottonrose hibiscus leaf
15 parts, 25 parts of dandelion, 15 parts of honeysuckle, 25 parts of Chinese holly leaf, 15 parts of radix semiaquilegiae, 15 parts of Prunella vulgaris；Preparation method is will be upper
It states 7 taste bulk pharmaceutical chemicals to add water to cook, filters off slag into liquid formulation.
Comparative example 2
This comparative example Chinese medicine liquid formulation is prepared by following raw material in parts by weight：40 parts of folium isatidis, cottonrose hibiscus leaf
15 parts, 25 parts of dandelion, 15 parts of honeysuckle, 25 parts of Chinese holly leaf, 15 parts of radix semiaquilegiae, 15 parts of Prunella vulgaris；Preparation method is the same as implementation
Example 1.
Comparative example 3
The formula of this comparative example Chinese medicine liquid formulation is same as Example 1, the difference is that being improved in preparation process
A concentration of the 70% of ethyl alcohol in edible alcohol.
Comparative example 4
The formula of this comparative example Chinese medicine liquid formulation is same as Example 1, the difference is that being reduced in preparation process
A concentration of the 50% of ethyl alcohol in edible alcohol.
Comparative example 5
This comparative example Chinese medicine liquid formulation save as different from Example 1 radix scutellariae, honeysuckle, the root of Dahurain angelica, asarum, Radix Astragali,
Safflower, preparation method is the same as embodiment 1.
Comparative example 6
This comparative example Chinese medicine liquid formulation saves Prunella vulgaris, the root of Dahurain angelica, asarum, Radix Astragali, safflower as different from Example 1,
Preparation method is the same as embodiment 1.
Comparative example 7
This comparative example Chinese medicine liquid formulation saves Prunella vulgaris as different from Example 1, and preparation method is the same as embodiment 1.
Comparative example 8
This comparative example Chinese medicine liquid formulation saves radix scutellariae, honeysuckle as different from Example 1, and preparation method is the same as implementation
Example 1.
Comparative example 9
This comparative example Chinese medicine liquid formulation saves the root of Dahurain angelica, asarum, Radix Astragali, safflower, preparation side as different from Example 1
Method is the same as embodiment 1.
1 clinical effectiveness statistical test of test example：
It uses Chinese medicine liquid formulation prepared by embodiment 1 to treat clinical diagnosis for the sufferer of lymph tuberculosis, unites
As a result the therapeutic effect of meter 248 shows that cure rate is 76.3%, effective 23.7%, total effective rate 100%.
The Chinese medicine liquid preparation of comparative example 1 is drug disclosed in Chinese patent CN10721494A, and the Chinese patent is public
It is 37.5% to the cure rate of lymph tuberculosis to have opened the drug, obvious effective rate 37.5%, total effective rate 75%.
By above-mentioned clinical statistics result it is found that Chinese medicine liquid formulation of the present invention is obviously excellent to the therapeutic effect of lymph tuberculosis
In comparative example 1, the present invention innovates compatibility relationship by the bulk pharmaceutical chemicals type to herb liquid state preparation, improves curative effect of medication.
2 tubercle bacillus antibiotic property of test example is tested
Test method：The Chinese medicine liquid formulation that respectively prepared by Example 1, comparative example 1~4 carries out tubercle bacillus biocidal property
Effect test, specific test method are using plating medium, to the sterilization rate of bacterium colony after the corresponding Chinese medicine liquid formulation of addition
It is counted, statistical result showed is 1 ＞ comparative examples of embodiment, 4 ＞ comparative examples, 3 ＞ comparisons to the sterilization rate size of tubercle bacillus
2 ＞ comparative examples 1 of example.
3 lymphocyte transformation test of test example
Test method：The Chinese medicine liquid formulation that respectively prepared by Example 1, comparative example 1~4 carries out lymphocytes in vitro and turns
Change experiment, lymphocytes in vitro conversion ratio after using corresponding Chinese medicine liquid formulation is counted, statistical result showed is external
The size of lymphocyte transformation rate is 3 ＞ comparative examples of embodiment 1 ＞ comparative examples, 4 ＞ comparative examples, 2 ＞ comparative examples 1.
4 wound healing of test example is tested
The big ear rabbit of 1.5~2.5Kg of weight health males is taken, 5mc wounds is cut in big leg outer side, creates wound healing experiment
Animal model creates five groups of wound healing experimental animal models, and every group of 6 experimental animals, every group of correspondence is in wound application reality
Apply example 1, Chinese medicine liquid formulation prepared by comparative example 1~4, daily application 2 times counts every group of experimental animal wound healing time,
As a result show that the wound healing time of 1 drug of application embodiment is 4~5 days, application comparative example 3, comparative example 4 and comparative example 2
Drug wound healing time is 6~7 days, and the drug wound healing time of application comparative example 1 is 9~10 days.It can be seen that this hair
The bright selection by bulk pharmaceutical chemicals type, innovates the compatibility relationship of each raw material, and selects suitable alcohol concentration and dosage, improves
To the Healing of wound.
5 active constituent content comparative test of test example
Detect the triterpene in embodiment 1, Chinese medicine liquid formulation prepared by 3~comparative example of comparative example 9 respectively using chromatography
The concentration of saponin(e and/or chlorogenic acid, active ingredient concentration in more different Chinese medicine liquid formulations, as a result shows：For three
9 ＞ comparative examples of concentration embodiment 1 ＞ comparative examples, 4 ＞ comparative examples, 3 ＞ comparative examples, the 8 ＞ comparative examples 5 of terpene saponin(e；For chlorogenic acid
9 ＞ comparative examples of concentration embodiment 1 ＞ comparative examples, 4 ＞ comparative examples, 3 ＞ comparative examples, 7 ＞ comparative examples 6.By the comparison result it is found that originally
According to the characteristic and compatibility relationship of each bulk pharmaceutical chemicals, creative selects concentration of alcohol to be soaked for 50% edible alcohol for invention
Bubble processing, and the suitable amounts of edible alcohol are limited, the active ingredient in bulk pharmaceutical chemicals is extracted to greatest extent, and is being soaked
The extraction that synergistic effect especially promotes monarch drug in a prescription and ministerial drug active ingredient is played during bubble between the active ingredient of each raw material, in turn
Improve the curative effect of medication of entire Chinese medicine liquid formulation.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (7)
1. a kind of antibacterial anti-inflammatory Chinese medicine composition, which is characterized in that be mainly prepared by following raw material in parts by weight：Summer is withered
0.8~1.2 part of grass, 0.8~1.2 part of radix scutellariae, 1.8~2.2 parts of honeysuckle, 0.8~1.2 part of the root of Dahurain angelica, 0.4~0.6 part of asarum, Huang
0.4~0.6 part of stilbene, 0.4~0.6 part of safflower.
2. antibacterial anti-inflammatory Chinese medicine composition as described in claim 1, which is characterized in that mainly by the raw material of following parts by weight
It is prepared：1 part of Prunella vulgaris, 1 part of radix scutellariae, 2 parts of honeysuckle, 1 part of the root of Dahurain angelica, 0.5 part of asarum, 0.5 part of Radix Astragali, 0.5 part of safflower.
3. antibacterial anti-inflammatory Chinese medicine composition as described in claim 1, which is characterized in that the dosage form of the Chinese medicine composition is liquid
State preparation.
4. a kind of preparation method of antibacterial anti-inflammatory Chinese medicine composition as claimed in claim 2, which is characterized in that including following behaviour
Make step：
1) each bulk pharmaceutical chemicals are weighed in parts by weight, the concentration of alcohol that 3~4 times of each bulk pharmaceutical chemicals total weight amount is added be 60% it is edible
It with alcohol, is impregnated 49 days under room temperature, filters off solid drugs, obtain liquid filtrate；
2) liquid filtrate prepared by step 1) is subjected to distillation processing, and recycles the ethyl alcohol distilled out；
3) water is added in step 2) distillation treated liquid filtrate and is diluted processing to required concentration, that is, complete.
5. the preparation method of antibacterial anti-inflammatory Chinese medicine composition as claimed in claim 4, which is characterized in that step in step 2)
1) the liquid filtrate prepared carries out distillation processing to concentration of alcohol in liquid filtrate less than 20%.
6. the preparation method of antibacterial anti-inflammatory Chinese medicine composition as claimed in claim 4, which is characterized in that water adds in step 3)
The volume ratio for entering the distillation of amount and step 2) treated liquid filtrate is 1：6.
7. the preparation method of antibacterial anti-inflammatory Chinese medicine composition as claimed in claim 4, which is characterized in that being added in step 1) can
Each bulk pharmaceutical chemicals are pre-processed before edible alcohol, pretreated specific method is：It is crushed to grain after each bulk pharmaceutical chemicals are mixed
Diameter size is 1~3mm.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062361A (en) * | 2007-05-29 | 2007-10-31 | 赵素兰 | Chinese traditional medicine for treating dermatosis and its preparation method |
| CN103877460A (en) * | 2014-02-26 | 2014-06-25 | 匡敬哲 | Medicine capable of treating tuberculosis and osteomyelitis |
| CN104666468A (en) * | 2015-03-20 | 2015-06-03 | 颜准 | Pharmaceutical composition for treating hyperthyroidism and scrofula |
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2018
- 2018-06-05 CN CN201810569413.XA patent/CN108542933A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062361A (en) * | 2007-05-29 | 2007-10-31 | 赵素兰 | Chinese traditional medicine for treating dermatosis and its preparation method |
| CN103877460A (en) * | 2014-02-26 | 2014-06-25 | 匡敬哲 | Medicine capable of treating tuberculosis and osteomyelitis |
| CN104666468A (en) * | 2015-03-20 | 2015-06-03 | 颜准 | Pharmaceutical composition for treating hyperthyroidism and scrofula |
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| Title |
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| 张方胜: "《中华传世医方 上 名医验方》", 31 May 1999, 科学技术文献出版社 * |
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Application publication date: 20180918 |