CN104127685A - Application of external-use plaster composition in preparation of drug used for treating skin injury - Google Patents
Application of external-use plaster composition in preparation of drug used for treating skin injury Download PDFInfo
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Abstract
The invention discloses an application of an external-use plaster composition in preparation of a drug used for treating skin injury. A experiment proves that the external-use plaster composition is significant in effects on treatment of skin injury, is quick in the effects, is slight in toxic and side effects, is a drug used for treating skin injury and promoting skin injury to heal safely, high-efficiently and stably, is simple in preparation process, is suitable for industrial production, is easy to popularize. The invention provides a new drug source for preventing and treating the skin injury.
Description
Technical field
The present invention relates to a kind of medicine for external use and uses thereof, particularly a kind of external Chinese medicament composite cream and in the application for the preparation of in treatment skin trauma medicine.
Background technology
Medicine for external use is in body surface or the application of some mucosal sites, has killing parasites for relieving itching, dispersing swelling and dissipating binds, the rotten evacuation of pus of change, promoting tissue regeneration and wound healing, more anastaltic medicines.External treatment side's medicine has the dosage forms such as cream, pellet, water, wine, loose, medicated line (medicine fourth), to affected part direct drug injection.Usage comprises patch, painting, applies, mixes, smokes, washes, soaks, bath, eye dripping, filling ear, collunarium, blow larynx and medicine fourth is inserted fistula etc.Medicine for external use has respectively the effects such as removing toxic substances and promoting subsidence of swelling, eliminating pus and toxicity, the flat Nu of putrefaction removing, promoting tissue regeneration and wound healing, hemostasis, parasite killing, antipruritic, foaming.Some drugs often has above-mentioned certain several function simultaneously; Some medicine also has supplementing the fire of vital gate to invigo rate YANG, dispelling wind and removing obstruction in the collateral, rush down lower logical stagnant, dissipating blood stasis analgesic therapy, broken knot eliminating mass, sputum eliminating to stop asthma, relieving convulsion, preventing the attack (or recurrence) of malaria, the treatment by oral administration of medicines effect such as have one's ideas straightened out.External used medicine can directly act on affected part, and targeting is strong, and little to organismic internal environment interference, instant effect, belongs to atraumatic therapy, is subject to patient and medical worker's extensive concern.
Skin trauma is the loss of epiderm skin tissue, commonly encountered diseases and frequently-occurring disease, wound after the wound that wound, angiopathy cause such as isolating, after scratch, surgical incision, diabetic wound, radiotherapy chemotherapy wound surface, skin ulcer, burn and scald, transplanting, decubital ulcer, cold injury, mosquito bite etc.Skin trauma is divided into 3 kinds, and first degree wound only limits to skin epidermis; Slightly severe one has skin and subcutaneous tissue fracture, and occurs wound; Serious wound has fracture and the fracture of muscle, flesh key, nerve.The wound that only limits to skin surface, heals by epithelium regeneration, and then both are because wound is serious, and skin repair healing needs manual intervention treatment often.
Theory of Chinese medical science thinks that sores ulceration of skin is generally by due to wound, so " surgeon " is used for making a general reference the traditional Chinese medical science of being engaged in surgery, dermatological department.According to < < week gift heavenly officials tomb, killing > > records: surgeon " palm abscess, ulcer, golden infections, fracture complicated with infection wish medicine, kill neat ".Abscess wherein refers to that redness holds the skin infection that pus does not have ulceration; Ulcer refers to that wound surface exposes the wound surface of infection or the ulceration that comes to a head; Gold infections refers to by the wound surface that occurs infecting after the injury of metal sharp weapon; Fracture complicated with infection is that the wound surface infecting appears in phalangeal fracture later.
The general treatment of skin trauma is emergent management wound site, then wait for the automatic healing of body, but this self-recovery needs the long period just can reach rehabilitation, and pain also can continue, therefore need to carry out trauma care to wound site, actively promote wound healing.Due to new epidermis and connective tissue, migration and the propagation by cell in wound healing process forms, and therefore promotes or stimulates the migration of cell that participates in wound healing, the medicine of Differentiation and proliferation can be used as trauma care.And lack clinically effective treatment means for skin depth damage and chronic skin ulcer disease, to patient mentally, bring great misery on health.
Skin burn brings great misery to patient, comprises the outward appearance of skin after pain, infection, indolence, healing and function reduction etc., badly influences patient's quality of life and physical and mental health.Decubital ulcer is that body part is organized long-term pressurized, disturbance of blood circulation, and local organization continuous ischemia, anoxia, lacks nutrition and cause skin to lose normal function, and the tissue causing is damaged and downright bad.Once there is not only to add heavy patient's the state of an illness in decubital ulcer, even secondary infection and jeopardize patient's life.The chronic trauma that diabetic wound and vascular conditions be representative of take is the disease that seriously perplexs patient, therapeutic effect is poor, wound face disunion or heal slow, immunoreation with body part and whole body, wound face apoptosis, the ability of the collagen that wound surface degraded by collagenase, fibroblast produce weakens, and cell is insensitive to external hypertrophy signal, and between somatomedin and receptor in target cell, the factor such as signal transduction " mistake is coupled " is relevant.During chronic ulcer, the apoptosis of wound site increases, cellular swelling, vacuolation and DNA fragmentation.In addition studies have shown that chronic ulcer may be due to the result of failing to control degraded by collagenase.In the wound surface of chronic ulcer, the collagenic ability of fibroblast weakens, and the respond of TGF-β and hypoxia stimulation is declined to some extent, and this reduces relevant with the TGF-β 2 receptor quantity of ulcer spot.In the wound of some chronic difficult healing, protease content increases, and when these digestive enzyme content reduce, healing is tending towards normal.In wound surface, the content of somatomedin depends on the balance between synthetic and degraded, and dysequilibrium will cause tissue repair obstacle.
Medicine for skin wound treatment has many kinds, is generally divided into dry method and wet method two classes.Dry method is mainly with convergence incrustation, and it is main path that the drug absorption wound surface discharge opeing of take forms duricrust oxygen protective layer; Wet method is keeping wound surface wet soft, under the unobstructed state of discharge opeing, and removing the necrotic tissue and promoting granulation.Dry method is with a long history, determined curative effect, but in therapeutic process, patient is more painful, and higher to treatment environmental requirement, after healing, there is cicatrix more.Wet method is low to treatment requirement for environmental conditions, and pain relieving is rapid, and after healing, skin is smooth.
In the medicine of existing treatment skin trauma, paraffin is commonly used for convergence, analgesic excipient, and Pulvis Talci has moisture absorption, holds back the effect of wound, and Calomelas is used as counteracting toxic substances, holds back wound.The medicines such as known lysozyme chloride, solcoseryl can be used as wound healing agent, and Chinese medicine preparation has good therapeutic effect to skin trauma as moist expose burn ointment, Kangfuxin Drop etc.
At present patient and medical personnel wish the wing and treat efficiently skin trauma medicine and have following effect: pain relieving rapidly, wound surface ooze out less, heal soon, normal without skin appearance after local infection, wound healing, without drug side effect or few side effects.But the current clinical medicine for skin wound treatment, local analgesia poor effect, wound healing speed is slow, can not effectively prevent traumatic infection, the problem that therapeutic agent does not have enough facilitations and can not make at short notice wound recover completely wound healing, and the medicine of existing treatment skin trauma exists the formation that can not resist cicatrix, the defects such as easily generation allergy to a certain extent.It is believed that, these problems be due to these therapeutic agent correspondences as synthetic, the improvement of peripheral circulation of the rehabilitation of the epidermis of the key factor in wound healing process, collagen, the contribution of the formation of granule, angiogenesis etc. is less.Therefore study and a kind ofly can promote skin healing, that can eliminate again the formation of trauma skin scar tissue has larger medical value and social meaning without anaphylactoid medicine.
Summary of the invention
The object of the invention is the technical problem existing for existing in preparation treatment skin trauma medicine, provide a kind of external Chinese medicament composite cream for the preparation for the treatment of skin trauma, promote the application in skin wound healing medicine or health food.External Chinese medicament composite cream of the present invention is at treatment skin trauma, promote to reduce inflammatory exudation in the process of skin wound healing, analgesia, antiinflammatory, draw out pus by applying a plaster to the affected part, granulation promoting effect is remarkable.
For realizing object of the present invention, one aspect of the present invention provides a kind of external Chinese medicament composite cream in the application for the preparation of in treatment skin trauma medicine.
Wherein, described skin trauma is skin injury or sores ulceration of skin.
Particularly, described skin injury is skin minor injury or skin depth damage; Described sores ulceration of skin is skin ulcer or skin ulceration.
Wherein, described skin depth damage is damaged property skin injury; Described skin ulcer is chronic skin ulcer or shallow phenotype skin ulcer.
Particularly, described chronic skin ulcer is one or more in diabetes type skin ulcer, chemical damage skin ulcer, decubital ulcer type skin ulcer, burn type skin ulcer, scald type skin ulcer, cold injury type skin ulcer, postoperative incision the disunion skin ulcer, the liquefaction of otch subcutaneous fat or the immunocompromised skin ulcer that cause.
Wherein, described external-applied ointment compositions exists with emplastrum, plaster, gel, ointment, liniment form.
Particularly, described emplastrum is rubber-emplastrum, cataplasma or patch; Described plaster is black plaster or white plaster; Described ointment is oil ointment or ointment agent.
Wherein, described external-applied ointment compositions is prepared from by following raw material: the Radix Rehmanniae, Radix Ampelopsis, Rhizoma Drynariae, Radix Notoginseng, Semen Persicae, Radix Rehmanniae Preparata, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei, Semen Momordicae, Plumbum preparatium, Semen Cucumidis sativi, leek seed, Semen Vitis viniferae, Pericarpium Citri Reticulatae Viride.
Particularly, the weight portion proportioning of described raw material is: Radix Rehmanniae 20-40, Radix Ampelopsis 20-35, Rhizoma Drynariae 20-45, Radix Notoginseng 25-60, Semen Persicae 20-40, Radix Rehmanniae Preparata 10-25, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-35, Cortex Cinnamomi 20-30, Radix Angelicae Dahuricae 20-45, Radix Angelicae Sinensis 20-35, Radix Paeoniae Rubra 25-45, Rhizoma Et Radix Notopterygii 15-30, Radix Sophorae Flavescentis 15-35, Radix Glycyrrhizae 15-25, Radix Angelicae Pubescentis 15-30, Radix Scrophulariae 15-35, Radix Et Rhizoma Rhei 10-25, Semen Momordicae 20-45, Plumbum preparatium 20-45, Semen Cucumidis sativi 10-25, leek seed 20-30, Semen Vitis viniferae 20-30, Pericarpium Citri Reticulatae Viride 30-50.
Especially, the weight portion proportioning of described raw material is: Radix Rehmanniae 25-30, Radix Ampelopsis 25-30, Rhizoma Drynariae 25-30, Radix Notoginseng 25-40, Semen Persicae 20-30, Radix Rehmanniae Preparata 15-25, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-30, Cortex Cinnamomi 25-30, Radix Angelicae Dahuricae 25-35, Radix Angelicae Sinensis 20-30, Radix Paeoniae Rubra 25-30, Rhizoma Et Radix Notopterygii 20-30, Radix Sophorae Flavescentis 25-30, Radix Glycyrrhizae 20-25, Radix Angelicae Pubescentis 20-30, Radix Scrophulariae 20-30, Radix Et Rhizoma Rhei 15-25, Semen Momordicae 20-35, Plumbum preparatium 25-40, Semen Cucumidis sativi 15-25, leek seed 25-30, Semen Vitis viniferae 20-25, Pericarpium Citri Reticulatae Viride 40-50.
Especially, described parts by weight of raw materials proportioning is: the Radix Rehmanniae 25, Radix Ampelopsis 25, Rhizoma Drynariae 25, Radix Notoginseng 25, Semen Persicae 25, Radix Rehmanniae Preparata 25, the Pseudobulbus Bletillae (Rhizoma Bletillae) 25, Cortex Cinnamomi 25, the Radix Angelicae Dahuricae 25, Radix Angelicae Sinensis 25, Radix Paeoniae Rubra 25, Rhizoma Et Radix Notopterygii 25, Radix Sophorae Flavescentis 25, Radix Glycyrrhizae 25, Radix Angelicae Pubescentis 25, Radix Scrophulariae 25, Radix Et Rhizoma Rhei 25, Semen Momordicae 25, Plumbum preparatium 25, Semen Cucumidis sativi 25, leek seed 25, Semen Vitis viniferae 25, Pericarpium Citri Reticulatae Viride 50.
External-applied ointment compositions of the present invention is selected the Radix Rehmanniae, Radix Ampelopsis, Rhizoma Drynariae, Radix Notoginseng, Semen Persicae, Radix Rehmanniae Preparata, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei, Semen Momordicae, Plumbum preparatium, Semen Cucumidis sativi, leek seed, Semen Vitis viniferae, Pericarpium Citri Reticulatae Viride combines and is prepared from, the mutual synergism of the active component of Chinese medicine, reach blood circulation promoting and blood stasis dispelling, dredge the meridian passage, kidney tonifying tonneau, reducing swelling and alleviating pain, nourishing blood and promoting granulation, the effect of health preserving toxin expelling, these Chinese herbal medicine are used in combination, make the active component in each medical material produce synergism, mutually promote effect, thereby effective alleviating pain, prophylactic effect, the externally applied ointment of this invention, easy to use, the treatment of subsides cave, impairing the liver kidney not, take medicine particularly strong, effect is unique, the treatment of external plaster cave, without any side effects.
Monarch drug is done in, invigorate blood circulation evacuation of pus sensible with the blood circulation promoting and blood stasis dispelling such as Radix Notoginseng, Semen Persicae, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Radix Sophorae Flavescentis, menstruction regulating and pain relieving, dredge the meridian passage, detumescence, dehumidifying, muscle-growing and detumescence, heat clearing and damp drying, the combination of eliminating stasis to stop pain medicine altogether, a large amount of activating blood and removing stasis drugs, logical regulating menstruation arteries and veins, promoting flow of QI and blood; Be aided with removing pathogenic heat from blood and toxic substance from the body, the Radix Et Rhizoma Rhei of eliminating blood stasis and inducing menstruation; Mass dissipating and swelling eliminating, counteracting toxic substances is treated the Semen Momordicae of skin ulcer, coordinates the Radix Angelicae Pubescentis of expelling wind and removing dampness, numbness relieving and pain relieving; The Radix Scrophulariae of removing heat from blood YIN nourishing, eliminating fire and detoxication; The Semen Cucumidis sativi of reunion of fractured tendons and bones; The kidney invigorating bone strengthening, continuous Rhizoma Drynariae of hindering pain relieving; The Radix Ampelopsis of removing obstruction for relieving pain, promoting tissue regeneration and ulcer healing is ministerial drug; Assistant take that nourishing YIN and supplementing blood, beneficial essence are filled out Radix Rehmanniae Preparata, the complement sun of marrow, the Cortex Cinnamomi of the merit of promoting blood circulation is adjuvant drug; Radix Glycyrrhizae can rise, can fall, and relaxes the property of medicine, and inducting the medicines into affected channel is for making medicine.Monarch drug, ministerial drug, adjuvant drug and medicine is cooperatively interacted, make the active component in each medical material produce synergism, mutually promotes its effect.
The Radix Rehmanniae is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa Libosch.), cool in nature, and sweet in the mouth, hardship, enter the heart, liver, kidney channel.Have clearing away heat and cooling blood, the effect of YIN nourishing and the production of body fluid promoting, is mainly used in calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, and hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, sends out speckle dermexanthesis.The chemical composition of Radix Rehmanniae mainly contains iridoid and glycoside thereof, sugar, aminoacid, organic acid, sterol, flavone and vitamin etc.Wherein, sterols mainly contains cupreol, stigmasterol, micro-campesterol; Flavone mainly contains luteolin, mountain balsam flavin; Iridoid and glycoside thereof mainly comprise catalpol, dihydro catalpol, acetylcatalpol, Herba Leonuri glycoside, aucubin, single sweet special power glycoside, sweet special power glycoside, sterol glycoside, iridoid A, B, C, D, Acteoside, compound saccharic, cerebroside, chlorination iridoid glycoside, Rehmannioside A, B, C, the bitter glycoside of Radix Rehmanniae etc.
Radix Ampelopsis is vitaceae Radix Ampelopsis Ampelopsis japonica(Thunb.) dried root of Makino.Bitter in the mouth, pungent; Cold nature; GUIXIN, lung, liver, spleen channel; The effect with heat-clearing and toxic substances removing, removing obstruction for relieving pain, promoting tissue regeneration and ulcer healing.Main sore swollen toxin, scrofula, scald, eczema, pyrexial malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula, leucorrhea, traumatic injury, traumatic hemorrhage.External, appropriate, grind into powder and spread or adjust painting.The tuber of Radix Ampelopsis is containing cement and starch, tartaric acid, cupreol, Fumaric acid, daucosterol.Pharmacological research shows that Radix Ampelopsis has inhibitory action to homocentricity trichophyton, microsporon audouini, epidermophyton inguinale etc.Root ethanol extract Methane Carboxylic Acid ester soluble fraction, causes mouse liver injury to carbon tetrachloride and has protective effect, and 300mg/kg significantly suppresses glutamate pyruvate transaminase (SGPT), the active rising of glutamic oxaloacetic transaminase, GOT (SGOT).Radix Ampelopsis decoct itself is without analgesic activity, but can significantly strengthen RADIX ACONITI LATERALIS PREPARATA and process the analgesic activity of Radix Aconiti, antagonism RADIX ACONITI LATERALIS PREPARATA, the contraction to isolated frog heart while processing Radix Aconiti and Radix Aconiti Kusnezoffii Preparata.It is that JTC-26 has inhibitory action that in vitro tests is cultivated human cervical carcinoma cell, and suppression ratio is more than 90%.
Rhizoma Drynariae is Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi Drynaria fortunei(Kunze) dry rhizome of J.Sm..Bitter in the mouth, warm in nature; Return kidney, Liver Channel; There is the kidney invigorating bone strengthening, continuous effect of hindering pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.The rhizome of Rhizoma Drynariae is starch-containing 16.4%, glucose 5.37%, also containing naringin, 21-hopenen, 9(11) fernene, 7-fernene (fern-7-ene,) 3-wild goose tooth alkene, cupreol, stigmasterol, oil recovery sterol and tetracyclic triterpenoid: ring jackfruit sterol-acetas, ring Rhizoma Polypodiodis Nipponicae steryl acetate (, cyclolaudenol acetas, 9,10-ring Pilus Caprae seu Ovis steroid-25-enol-3 β-acetas.
Rhizoma Drynariae water decoction gavage, has the effect of the bone articular cartilage of stimulation cell compensatory hypertrophy to rat experiment arthritis, and can partly improve because mechanical stress line changes the degeneration that causes articular cartilage, thereby reduce osteoarthritis variability.Rhizoma Drynariae flavanone glycoside can increase the Beating Rate of In vitro culture rat neonatal rat myocardial cell, makes to shrink effectively, and myocardial cell is had to pace-making effect.Oral Rhizoma Drynariae decocting liquid is to the obviously rising of prophylactic serum cholesterol, triglyceride of Experimental Hyperlipemia rabbit, and can prevent the formation of aorta wall atherosclerotic plaque.Rhizoma Drynariae decoct and kanamycin share and can alleviate the toxic action of kanamycin to cochlea.Rhizoma Drynariae decoct can suppress staphylococcic growth in vitro.Oral Rhizoma Drynariae water decoction, to chondrocytes of rat osteoarthritis mode, tool have some improvement chondrocyte, postpone cell degeneration, reduce the function of osteoarthritis variability, with dosage, strengthen, effect increases, and after two months, acts on better in administration.
Radix Notoginseng claims again Radix Notoginseng, Yunnan seven, Radix Notoginseng, Radix Notoginseng, is the dry root of panax araliaceae plant.Warm in nature, sweet in the mouth, micro-hardship, returns liver, stomach warp.There is dissipating blood stasis hemostasis, subduing swelling and relieving pain.For spitting of blood, to spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast abdomen twinges, tumbling and swelling.In Radix Notoginseng, mainly contain the active component of multiple dammarane type four-ring triterpenoid Saponin.As arasaponin A, arasaponin B, after the two hydrolysis, generate respectively ruscogenin A, ruscogenin B and a part glucose; Also contain ginsenoside-Rb1 ,-Rb2 ,-Rd ,-Re ,-Rg1, Herb Gynostemmae Pentaphylli glycoside, dencichine (being dencichine), sanchinan-A, B and the multiple human body with anastalsis must aminoacid (as glutamic acid, arginine, lysine, leucine etc.).
Modern pharmacological research shows that Radix Notoginseng can improve the immunocompetence of body, can significantly improve phagocytic rate and the phagocytic index of Turnover of Mouse Peritoneal Macrophages.Wherein, sanchinan-A can obviously reduce natural killer cell (NKC) activity, and when drug dose strengthens, inhibitory action is strengthened.During Polysaccharide B low concentration, can obviously promote natural killer cell (NKC) activity, with concentration, increase facilitation and weaken.Polysaccharide A makes serum lysozyme content increase when 25mg/kg, and other dosage is without impact; Polysaccharide B also has facilitation to lysozyme.Polysaccharide A can make peritoneal exudate cells lysozyme content increase when 5mg/kg, and when 25mg/kg is above, can make endocellular enzyme content significantly increase, and can make enzyme content increase during Polysaccharide B low dosage, and high dose is without impact.Two kinds of Polysaccharides on Mice antigen binding cell all have inhibitory action, and the inhibitory action of Polysaccharide A is strengthened with the increase of dosage, and Polysaccharide B inhibitory action when the above dosage of 25mg/kg is plateau phenomenon.Two kinds of polysaccharide antagonist secretory cells of Radix Notoginseng all have obvious inhibitory action.Two kinds of polysaccharide form cell (PFC) to hemolysis plaque also all obvious inhibitory action.Radix Notoginseng total arasaponins (PNS) can also significantly improve the effect of pulmonary alveolar macrophage phagocytic rate, shows to Wistar rats by intraperitoneal injection Radix Notoginseng total arasaponins, result, and administration group pulmonary alveolar macrophage phagocytic rate significantly improves, and after administration, blood leucocyte sum improves obviously.Rat oral gavage Radix Notoginseng total arasaponins to Ovum Gallus domesticus album pedal swelling, the total Saponin of presentation of results Radix Notoginseng fibrous root has obvious antiinflammatory inhibitory action to rat Ovum Gallus domesticus album pedal swelling.Radix Notoginseng extract can improve body hepatic glycogen, normal mouse gavage Radix Notoginseng extract 15 days and 25 days, and hepatic glycogen improves respectively 80.8% and 71%.Presentation of results Radix Notoginseng extract can promote mice to utilize exogenous glucose to synthesize hepatic glycogen, and in the hepatocyte of the mice of administration Radix Notoginseng extract, most glycogen granulees are thick full.
Semen Persicae is the seed of rosaceous plant Fructus Persicae or Prunus davidiana, and bitter in the mouth, sweet, property are flat; Enter the heart, liver, large intestine channel, there is blood stasis removing and clots absorbing, moisturize the effect of laxation, be mainly used in treating the diseases such as amenorrhea, mass in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, congestion swell and ache, the dry constipation of blood.Semen Persicae contains a large amount of amygdalins, emulsin, allantoinase, Lactose enzyme, vitamin B1, volatile oil, fatty oil; Wherein main containing olein and a small amount of glyceryl linoleate in oil; Emulsin comprises amygdalase and prunase.Amygdalin in Semen Persicae is the same with the amygdalin in Semen Armeniacae Amarum, produces hydrocyanic acid, benzaldehyde and glucose after enzyme or acid hydrolysis.
Modern pharmacological research shows: the alcohol extract of Semen Persicae has anticoagulant effect and weak haemolysis.Semen Persicae energy blood vessel dilating, has the effect of invigorating blood circulation and blood coagulation resisting function, improves cAMP level in platelet, suppresses blood coagulation; Semen Persicae also has antiinflammatory, anti-allergic effects; The antitumor action of Semen Persicae is mainly by the hydrolyzate hydrocyanic acid of amygdalin and benzaldehyde, the collaborative destruction of cancerous cell to be realized; The hydrocyanic acid and the benzaldehyde that after the amygdalin hydrolysis containing in Semen Persicae, generate have sedation to respiratory center, hydrocyanic acid is after absorbing, suppress cytochrome oxidase, during low concentration, reduce and organize oxygen consumption, and suppress the oxidative metabolism of carotid body and aortic body and reflexive make exaggerated respiration, make the easy expectoration of expectorant, and reach the effect of antitussive.In addition, Semen Persicae also has hypotensive effect; Semen Persicae extract is all improved effect and reduces blood viscosity hepatic necrosis degeneration and fibrosis, increases blood flow, pylic effect in expansion liver.
Radix Rehmanniae Preparata is the Preparation process product of Radix Rehmanniae.Sweet in the mouth, slightly warm in nature.Return liver, kidney channel.Have nourishing YIN and supplementing blood, beneficial essence is filled out the usefulness of marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.
The Pseudobulbus Bletillae (Rhizoma Bletillae) is orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletilla striata(Thunb.) dry tuber of Reichb.f..Bitter in the mouth, sweet, puckery; Cold nature.Return lung, liver, stomach warp.There is astringing to arrest bleeding, the effect of detumescence and promoting granulation.For hemoptysis, spit blood, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Pseudobulbus Bletillae (Rhizoma Bletillae) fresh tuber moisture content 14.6%, starch 30.48%, glucose 1.5%.Again containing volatile oil, phlegmatic temperament.Root is containing bletilla mannan, by 4 parts of mannose and 1 part of glucomannan that glucose forms.
The Pseudobulbus Bletillae (Rhizoma Bletillae) can be treated burn and surgical wound, and the fresh Pseudobulbus Bletillae (Rhizoma Bletillae) epidermis of pruning, makes mucilago salep.On the wound surface of partial trauma or first and second degree burn, smear Pseudobulbus Bletillae (Rhizoma Bletillae) rubber cement, after coating, with kpetrolatum gauze, cover, wrapping is fixing, through 1～3 time, cures.Mucilago salep is for general surgical wound and burn, and its therapeutical effect may be: (i) pass through neural reflex mechanism and the protection capability of enhancing body, stimulate granulation tissue hyperplasia; (ii) staphylococcus and streptococcus are had to bacteriostasis, and can form in part a protecting film, can control and protect from infection; (iii) can shorten the blood clotting time, reduce hemorrhage, thereby be conducive to the healing of wound surface.The styptic powder that Pseudobulbus Bletillae (Rhizoma Bletillae) is made, has good haemostatic effect to little angiorrbagia and the oozing of blood of the skin of some operation, flesh layer otch, better to the haemostatic effect after exodontia; Application Rhizoma Bletillae powder is treated schistosomicide esophagus, the Gastric variceal bleeding in late period, and ulcerative colitis is hemorrhage, and purpura hemorrhagica, and oral mucosa tuberculous ulcer, all have certain curative effect.The rat pipe film injury that the Pseudobulbus Bletillae (Rhizoma Bletillae) also causes hydrochloric acid has obvious cytoprotection.Pseudobulbus Bletillae (Rhizoma Bletillae) decoct is not by gastric acid secretion inhibiting to the mechanism of gastric mucosal protective effect, and is likely that stimulation gastric mucosa synthesizes and release endogenous prostaglandin is realized.The immersion of Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol has inhibitory action to bacillus subtilis, staphylococcus aureus, Candida albicans ATCC1057 and Trichophyton QM248.
Cortex Cinnamomi is dried bark and the branch skin of canella Cortex Cinnamomi.The treelet dried bark and the thick branch skin that strip the cultivation canella Cortex Cinnamomi of 5～6 years, shone after 1～2 day, is rolled into cylindricly, dries in the shade and make Cortex Cinnamomi.Acrid in the mouth, sweet; Hot in nature; Return kidney, spleen, urinary bladder channel; There is complement sun, warming the spleen and stomach, removing accumulated cold, the effect of promoting blood circulation.Be used for controlling decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.The skin of Cortex Cinnamomi is containing volatile oil (title Oleum Cinnamomi) 1～2%, main component is cinnamic aldehyde 75～90%, and containing a small amount of acetic acid Cortex cinnamomi japonici (Ramulus Cinnamomi) ester, phenylpropyl acetate, ethyl cinnamate, benzyl benzoate, benzaldehyde, coumarin, β-cadinene, Rhizoma Acori Graminei alkene, beta-elemene, protocatechuic acid, trans isomer cinnamic acid etc., mucous, tannin etc. still.
The cinnamic aldehyde containing in Cortex Cinnamomi has obvious sedation to mice, shows as spontaneous activity and reduces.The movement disorder of crossing multi-activity, rotating stick test generation that antagonism methamphetamine produces and the anesthesia duration of prolongation ciclobarbital soluble etc.It has analgesic activity the method proof that application mice presses anal spine to swash or lumbar injection acetic acid observation writhing is moved.To mice normal body temperature and by the artificial fever that typhoid fever, paratyphoid fever mixed vaccine cause, all there is cooling effect.The rabbit that temperature thorn is caused to heating, cinnamic aldehyde and Fortificar have refrigeration function.Tonic convulsion and dead time that strychnine causes can be postponed, tonic convulsion and dead incidence rate that nicotine causes can be reduced.Oleum Cinnamomi has powerful bactericidal action, better than negative patient to the effect of G+ bacteria, and because of irritant, seldom as antibacterials, but external application can be treated stomachache, flatulence angor etc.
The Radix Angelicae Dahuricae claims again fragrance, membrane inside the rush stalk Li, Ze Fen, white Chai, Radix Angelicae Dahuricae (Radix Heraclei Scabridi), is the root of samphire Yu Radix Angelicae Dahuricae, Xingan's Radix Angelicae Dahuricae, angelica anomala, Radix angelicae dahuricae or Yunnan cattle Radix Saposhnikoviae.Radix Angelicae Dahuricae acrid in the mouth, warm in nature; Return lung, stomach, large intestine channel; Fragrance rises loose.Have expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidifies sensible, the evacuation of pus of invigorating blood circulation, and the effect of muscle-growing and detumescence, is mainly used in treating anemofrigid cold, headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, pruritus scabies, venom.The Radix Angelicae Dahuricae contains containing isoimperatorin, imperatorin, bergapton, xanthotoxin, phellopterin, scopoletin, oxypeucedanin etc.
Modern pharmacological research shows that the Radix Angelicae Dahuricae has: 1) antiinflammatory action: the mouse stomach Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct can obviously suppress the inflammation of dimethylbenzene induced mice ear; 2) antipyretic effect: the mouse stomach Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct, its antipyretic effect and aminophenazone are similar; 3) spasmolysis: the Radix Angelicae Dahuricae contains bergapton, xanthotoxin, isoimperatorin rabbit ileum is had to obvious spasmolysis.Isoimperatorin can also increase the tonicity of contractility and the Lumbricus flesh of rabbit uterus.Scopoletin has spasmolysis at body or isolated rat hysterospasm due to estrogen or barium chloride; 4) to cardiovascular effect: isoimperatorin has the effect of blood pressure lowering to cat, the blood pressure lowering time is long, can also reduce the contractility of isolated frog heart; 5) antibacterial action: the contained Oxypeucedannin in vitro tests of the Radix Angelicae Dahuricae has antibacterial action to 11 kinds of bacterial strains such as escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis; 6) photosensitization: contained bergapten, xanthotoxin, the isoimperatorin the second grade furocoumarin compound of the Radix Angelicae Dahuricae is optical active substance, when they enter after body, can be used to treat the dermatosiss such as vitiligo, psoriasis, isoimperatorin is the psoriatic effective ingredient for the treatment of; 7) antitumaous effect: isoimperatorin has the cytotoxicity to Hela cell.
When being classified as umbelliferae angelica Angelica sinensis(Oliv.) dry root of Diels, sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the merit of loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Angelica root is containing volatile oil, and volatilization main body of oil has: butylidenephthalide, the positive pentanone of adjacent carboxyl benzene and Δ 2,4-dihydro acid phthalic anhydride.Radix Angelicae Sinensis volatile oil complicated component, is singly that low boiling part just has kind more than 10, wherein has multiple hydro carbons, comprises 3 kinds of terpenes.Another containing volume sucrose (40%), vitamin B12 (0.25～40 microgram/100 gram), retinoid material (in vitamin A, being 0.0675% containing rate).In the saponification part of root, contain Palmic acid, stearic acid, myristic acid and unsaturated oleic acid, sub-kojic acid; In not saponification composition, there is cupreol.
Radix Angelicae Sinensis contains two kinds of compositions excited and inhibition uterine smooth muscle, has amphicheirality's effect.Suppress composition and be mainly volatile oil, excited composition is water solublity or alcohol dissolubility and the insoluble nonvolatile matter of ether.Eumenol has the effect of remarkable expansion isolated guinea pig coronary, increases coronary flow.During 25% Radix Angelicae Sinensis decoct Bufo siccus blood vessel perfusion, there is pressor effect; Radix Angelicae Sinensis and Ferulic Acid thereof affect rat platelet aggregation and 5-HT discharges, and Radix Angelicae Sinensis and ferulic acid anticoagulant system are by suppressing platelet release reaction.Aspect some pharmacologically active, Radix Angelicae Sinensis and Ferulic Acid thereof and aspirin have similarity.Radix Angelicae Sinensis and sodium ferulate thereof have obvious anti thrombotic action.Rat experiment shows, Radix Angelicae Sinensis can make thrombosis dry weight significantly reduce, thrombosis growth recession.Acute ischemic stroke patient is after angelica for treating, and viscosity of blood reduces, and plasma fibrinogen reduces, prolonged prothrombin, erythrocyte and platelet electrophoresis time shorten.Hemorheology Study shows, Radix Angelicae Sinensis may increase cell surface charge, and promote cell depolymerization by reducing plasma fibrinogen concentration, reduces blood viscosity.The anti thrombotic action of Radix Angelicae Sinensis may be relevant with reduction viscosity of blood with anticoagulant, and ligustilide may be one of its effective ingredient.Radix Angelicae Sinensis infusion can significantly promote hemoglobin and erythrocytic generation to mice po.Its anti-anemia effect may be relevant with compositions such as contained vitamin B12, nicotinic acid, folinic acid and biotin, folic acid.Radix Angelicae Sinensis can also significantly strengthen the phagocytic function of animal peritoneal macrophage, improves the clean up speed of reticuloendothelial system to dyestuff.Radix Angelicae Sinensis aqueous extract can reduce vascular permeability, can suppress in platelet inflammation-causing substance as the release of 5-HT, thereby produces antiinflammatory action.Radix Angelicae Sinensis significantly suppresses mice auricle swelling, and Radix Angelicae Sinensis has obvious inhibitory action to the footpad swelling of proinflammatory agent.
Radix Paeoniae Rubra is the root of ranunculaceae plant Radix Paeoniae (wild species), Paeonia obovata Maxim., river Radix Paeoniae Rubra etc., the wooden Radix Paeoniae that has another name called (Cui leopard < < notes > > at all times), red Radix Paeoniae.Be slightly cold, sour in the mouth, hardship, return liver, spleen channel.Have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, is mainly used in maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.
Radix Paeoniae Rubra mainly contains paeoniflorin, oxypaeoniflorin, benzoylpaeoniflorin, albiflorin, paeoniflorin without ketone, Galla Turcica (Galla Helepensis) acyl paeoniflorin, Lactiflorin., peony lactone etc.; also contain cupreol, daucosterol, infanticide acyl glucose, dextrorotation cachou extract and volatile oil, wherein volatile oil is mainly containing benzoic acid, paeonol and other alcohols and phenols component.Paeoniflorin content in root is high, entirely in root bark part.Modern pharmacological research explanation Radix Paeoniae Rubra has spasmolytic, blood pressure lowering, increase blood flow, analgesia, calmness, convulsion; Antiinflammatory, antiulcer, the pharmacological action such as antibacterial, antipyretic.
Rhizoma Et Radix Notopterygii is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii (back of the body wing celery) Notopterygium incisum Ting ex H.T.Chang or Radix et Rhizoma Notopterygii Notopterygium forbesii Boiss..Acrid in the mouth, hardship; Warm in nature; Return bladder, kidney channel.There is cold expelling, dispel the wind, dehumidifying, the merit of pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.Rhizome is containing Coumarins compound: different imperatorin, the different imperatorin of 8-methoxyl group, 5-hydroxyl bergmot element, bergapten, 8-(3,3-dimethyl-allyl)-5 demethyl bergaptens, 5-demethyl bergmot alcohol, decuroside unit, decuroside, bergmot alcohol-O-β-D-Glucopyranose., the trans-Resina Ferulae acyl of 6-O-decuroside, columbianetin, columbianetin glycoside, imperatorin; Contain phenoloid: p-leptodactyline Fructus Foeniculi acid esters, ferulic acid; Contain phytosterin compound: daucosterol, sitosterol; Containing volatile oil as α-thujene, α and nopinene, β ocimene, γ-terpinene, limonene, 4-terpinenol, borneol acetate, α-(king is ancient) (king's bar) alkene, trans-β-farnesene, parsley brain, guiol and benzyl benzoate; Fatty acids, amino acids and carbohydrate admixture.
Modern pharmacological research shows that Rhizoma Et Radix Notopterygii has antipyretic effect.2.5h after rat skin lower injection l5% yeast suspension 10ml/kg pyrogenicity, then respectively with Rhizoma Et Radix Notopterygii volatile oil 1.328ml/kg gavage and 0.133ml/kg gastric infusion, after administration, different time is surveyed rat temperature.Result shows that Rhizoma Et Radix Notopterygii volatile oil can make rat temperature obviously reduce, and has obvious refrigeration function.Analgesic effect, the volatile oil of Rhizoma Et Radix Notopterygii for three days on end, has obvious minimizing to the writhing number of times of lumbar injection 0.5% acetum 0.2ml/kgl0 minute.The effect of detumescence: mice is gavage Rhizoma Et Radix Notopterygii volatile oil respectively, can significantly suppress mice dimethylbenzene dropsy of ear; To rat carrageenan, foot swelling has inhibitory action to oral Rhizoma Et Radix Notopterygii volatile oil; Can significantly reduce the foot swelling of rat dextran.
Radix Sophorae Flavescentis is the dry root of leguminous plant Radix Sophorae Flavescentis, cold in nature, bitter in the mouth, and GUIXIN, liver, stomach, large intestine, urinary bladder channel, have heat clearing and damp drying, parasite killing, the function of diuresis, is used for the treatment of hematodiarrhoea, has blood in stool, and jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.Radix Sophorae Flavescentis is slightly poisonous, and consumption is difficult for excessive.In Radix Sophorae Flavescentis, contain multiple alkaloid, main component is d-Matrine, d-Oxymatrine, sophoranl l-Anagyrine, l-methylcytisine, l-baptifoline and sophocarpine.Also containing flavonoid: xanthohumol, isoxanthohumol, 3,4 ', 5-tri-hydroxyls-7-methoxy-8-isoamylene radical chromocor, 8-prenylkaempferol etc.
The pharmacological action of Radix Sophorae Flavescentis is as follows: (1) diuresis: Radix Sophorae Flavescentis decoct and wherein contained matrine be oral or injection to rabbit, all can produce diuresis; (2) antitumor action: effect, sophocarpine that matrine has reduction Turnover of Mouse Peritoneal Macrophages inhibition P815 tumor cell proliferation in vitro all show obvious inhibitory action to tumor strains such as S-180, U-14.ECA, L in experiment mice body.The tumour inhibiting rate of each monosomic alkali is all more than 35%; Matrine has significant inhibitory action to chronic myelocytic leukemia periphery multipotential hematopoietic progenitors colony generation rate in addition, and suppression ratio reaches 0.76; Radix Sophorae Flavescentis decocting liquid significantly inducing leukemia cell breaks up to mononuclear phagocyte direction; (3) effect in increasing leukocyte: oxymatrine can prevent that mice is because of MMC, caused by cyclophosphamide murine interleukin minimizing disease, intravenous injection or intramuscular injection Radix Sophorae Flavescentis total alkaloids and oxymatrine have obvious rising effect to normal Peripheral Blood in Rabbits leukocyte count, rise white effect and are better than batilol; (4) Radix Sophorae Flavescentis alkaloid has blood vessel dilating and obvious to the protective effect of acute myocardial ischemia, hypotensive effect, and oxymatrine also can increase atrial contractility; (5) antipathogen effect: Radix Sophorae Flavescentis decoct has inhibitory action to tubercule bacillus; Water logging agent has inhibitory action in various degree to common dermatophytes in vitro.Alcohol extractum still has anti-trichomonal effect in vitro.
Radix Glycyrrhizae another name for Herba Hedyotis cantonensis root, Radix Glycyrrhizae, Radix Glycyrrhizae, Glycyrrhizae, close sweet, close grass, state are old, Radix Glycyrrhizae, Herba Hedyotis cantonensis, sweet root, rod grass, be the dry root and rhizome of glycyrrhizic legume (Glycyrrhiza uralensis Fisch.), Glycyrrhiza inflata Bat. (Glycyrrhizainflata Bat.) or Glycyrrhiza glabra L. (Glycyrrhiza glabra L.).Radix Glycyrrhizae property is flat, sweet in the mouth, GUIXIN, lung, spleen, stomach warp.The raw product of Radix Glycyrrhizae are used as medicine, can eliminating fire and detoxication, lung moistening expelling phlegm for arresting cough, be used for the treatment of laryngopharynx swelling and pain, and medicine, alimentary toxicosis, the diseases such as cough, asthma; After processing, be used as medicine, can QI invigorating invigorating middle warmer, relieving spasm to stop pain, the mitigation property of medicine, be used for the treatment of deficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, weakness of the spleen and stomach, insufficiency of vital energy and blood, lassitude, and the disease such as the anxious pain of spasm in abdomen.The property of medicine of Radix Glycyrrhizae relaxes, and can rise, can fall, and can be used in conjunction with the various kinds of drug such as tonic, cathartic, cold medicine, warm medicine, the medicine of a cold nature, and have the property of medicine, cushion toxicity, the strong effect of being in harmonious proportion.
Radix Angelicae Pubescentis is to be the dry root of samphire Angelica pubescens, slightly warm in nature, and acrid in the mouth, hardship, return kidney, urinary bladder channel, has expelling wind and removing dampness, the effect of numbness relieving and pain relieving, for anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.Radix Angelicae Pubescentis contains the multiple furoeoumarin classes such as angelol, angelicin, bergapton, osthole, umbelliferone, scopoletin, angelic acid .beta.-methylacrylic acid, brown eleostearic acid, stearic acid, oleic acid, linolenic acid, plant sterol, glucose and a small amount of volatile oil, Radix Angelicae Dahuricae element, bergenin, bergapton, xanthotoxin, sphondin, isopimpinellin, isobergapten.Pharmacological testing shows, Radix Angelicae Pubescentis has the activity of antagonism calcium channel blocker receptor, and Radix Angelicae Pubescentis decoct can obviously extend the animal pain reaction time that hot plate method in mice causes, and shows that Radix Angelicae Pubescentis has obvious analgesic activity.Radix Angelicae Pubescentis fluid extract, Radix Angelicae Pubescentis decoct be to mice or rat oral gavage or subcutaneous injection administration, the animal appearance psycheism that all behaves with composure; Radix Angelicae Pubescentis shows to have antimicrobial spectrum widely to 11 kinds of bacterial strain tests in vitro; Experimental Gastric Ucler is had to the protective effect of moderate strength.Xanthotoxin and bergapten that Radix Angelicae Pubescentis contains have killing action to ehrlich ascites cell.
Radix Scrophulariae claims again Radix Scrophulariae, is the dry root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl..Sweet in the mouth, hardship, salty; Cold nature.Return lung, stomach, kidney channel.There is removing heat from blood YIN nourishing, the effect of eliminating fire and detoxication.Be mainly used in treating consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.Mainly contain iridoid: such as harpagide, harpagoside, aucubin, 6-O-methycatalpol, 2-(3-hydroxyl-4-methoxyphenyl) ethyl 1-O-[α-L-arabinose base (1 → 6)]-[Resina Ferulae acyl group (1 → 4)]-α-L-rhamanopyranosyl (1 → 3)-β-D-Glucose glycoside (1 → 6)]-[Resina Ferulae acyl group (1 → 4)]-α-L-rhamanopyranosyl (1 → 3)-β-D-Glucose glycoside, aminoacid, fatty acid, trace volatile oil, carotene etc.The modern pharmacological research of Radix Scrophulariae shows that Radix Scrophulariae has antibacterial action, and 50% decoct plate dilution method, has inhibitory action to staphylococcus aureus.The flat board method that burrows for the fresh method of Radix Scrophulariae leaf, has inhibitory action to bacillus pyocyaneus.Preserved material tube dilution method, 1:160 has inhibitory action to tinea barbae trichobacteria, microsporum canis; Also to multiple pathogenic and non-pathogenic fungus is inhibited; Extractum has slight hypoglycemic activity to rabbit.
Radix Et Rhizoma Rhei another name general, raw army, Radix Et Rhizoma Rhei are the dry root and rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Radix Et Rhizoma Rhei is cold in nature, and bitter in the mouth is returned spleen, stomach, large intestine, liver, pericardium channel.There is purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, the function of eliminating blood stasis and inducing menstruation, is used for the treatment of excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury.Main pharmacodynamics composition in Radix Et Rhizoma Rhei has anthracene derivative, glycosides compound, tannin class, organic acid, volatile oil etc.Anthracene derivative: 1. Anthraquinone derivative, as aloe-emodin, chrysaron, chrysophanol, emodin, isoemodin, physcione, chrysophanic acid; 2. combined anthraquinone compound: the single and double glycoside of chrysophanic acid, aloe-emodin, chrysophanol; The monosaccharide glycoside of emodin, physcione; 3. anthrol and anthrone compound: reidin, palm leaf dianthrone and with the glycoside of sugared combination as Sennoside A, B, C, D, E, F etc.Glycosides compound: rhaponticin, Resveratrol alkene-4 '-O-β-D-(6 '-O-Galla Turcica (Galla Helepensis) acyl) glycoside, 3,5,4 '-trihydroxy stilbene alkene-4 '-O-β-D-glucopyanoside etc.Tannin class: galloyl glucose, d-catechin, gallic acid, tetrarin etc.Tetrarin, through hydrolysis, obtains gallic acid, cinnamic acid and rheosmin.In addition containing volatile oil, plant sterol, resin and organic acid etc.
The pharmacological research of Radix Et Rhizoma Rhei shows that Radix Et Rhizoma Rhei has discharge function, and the Sennosides in Radix Et Rhizoma Rhei decomposes and produces chrysophanic acid anthrone under the effect of intestinal bacteria enzyme, and chrysophanic acid anthrone stimulates colorectal mucosa, enterokinesia is increased and under rushing down.Also can suppress Na on gut cell membrane in addition
+, K
+-ATP enzyme, hinders Na
+transhipment, raises enteral osmotic pressure, retains large quantity of moisture, promotes enterokinesia and under rushing down; Anastalsis, its effective ingredient α-catechin, gallic acid can promote hematoblastic adhesion and aggregation capability, increase platelet count and fibrinogen content, reduce antithrombin Ⅲ active, make the vasoconstriction of injured part, and then hemostasis.Anti-infectious function, the antibiotic effective ingredient in Radix Et Rhizoma Rhei is chrysophanic acid, emodin, aloe-emodin, Radix Et Rhizoma Rhei energy anti-bacteria nucleic acid and protein synthesis; Anti-bacteria biological oxidation enzyme system; Inducement interferon.
Semen Momordicae is cucurbitaceous plant Semen Momordicae Momordica cochinchinensis(Lour.) dry mature seed of Spreng., claim again Semen Momordicae.Bitter in the mouth, micro-sweet, cool in nature, poisonous; Return liver, spleen, stomach warp; Have mass dissipating and swelling eliminating, counteracting toxic substances is treated the effect of skin ulcer, is mainly used in treating sore swollen toxin, acute mastitis, scrofula, anal fistula, chronic eczema, tinea alba.External: grind into powder and dress, grind juice painting or decoct water smoking and wash.Semen Momordicae contains momordic acid (momordic acid), gypsogenin (gypsogenin), oleanolic acid (oleanolic acid), alpha-eleostearic acid (α-elaeostearic acid), the acid of gas base, sterol.
Plumbum preparatium claims again Plumbum preparatium, Plumbum preparatium, Zhu Dan, the lead orthoplumbate (Pb forming through processing and manufacturing for pure lead
3o
4), the fine powder that orange-yellow or orange red chromaticness is heavy, gloss is dim, opaque, touches it, smooth exquisiteness with hands.Water insoluble, be partially soluble in thin liquid.Acrid in the mouth, salty, cold nature is poisonous.There is removing toxic substances and promoting tissue regeneration, sore.Sore swollen toxin is controlled in external, wound hemorrhage, burn and scald.Suitable amount used externally.As the bodying agent that boils plaster.
Semen Cucumidis sativi is the seed of cucurbitaceous plant Fructus Cucumidis sativi.Fatty oil, wherein oleic acid 58.49%, linoleic acid 22.29%, Palmic acid 6.79%, stearic acid 3.72%.There is reunion of fractured tendons and bones; Dispel the wind; The effect of expectorant.Be mainly used in the treatment fracture injury of tendon and muscle; Rheumatic arthralgia; Old phlegm dyspnea.External: appropriate, grind into powder and dress.
Leek seed is the dry mature seed of liliaceous plant Folium Allii tuberosi Allium tuberosum Rottl..Acrid in the mouth, sweet, warm in nature.Return liver, kidney channel.There is temperature compensation Liver and kidney, the merit of tonifying YANG controlling nocturnal emission with astringent drugs.For impotence and seminal emission, soreness of waist and knee joint, enuresis frequent micturition, nebulousurine leukorrhagia.Leek seed sulfur compound, glycoside, vitamin C etc.
Semen Vitis viniferae is the leftover bits and pieces of grape wine factory, products therefrom after separated Pericarpium Vitis viniferae, stem of Fructus Vitis viniferae after drying.Semen Vitis viniferae contains and enriches each seed amino acid, vitamin and mineral etc.Oleum Vitis viniferae has the effect of health care, beauty treatment because of it.Grape seed extract OPC has superpower oxidation resistance, is 50 times of vitamin e, energy delaying aging, and prevention of arterial hardens, and also has the title of skin vitamin, is 20 times of vitamin C, and phenol anthocyanidin wherein, according to fat-soluble and water miscible speciality, has whitening function; Semen Vitis viniferae extract has inhibition and removing free radical, antioxidation, anti-prostate cancer, anti-liver neoplasm, brings into play anticancer antianaphylactic effect, can also resist neural damage.The division of Semen Vitis viniferae energy irritation cell and tissue regeneration, activation cells of superficial layer, reduces wrinkle, slow down aging; The effect of anti-prostate cancer, anti-liver neoplasm, can also resist neural damage.
Pericarpium Citri Reticulatae Viride is the dry young fruit of rutaceae orange Citrus reticulata Blanco and variety thereof or the peel of immature fruit.Bitter in the mouth, pungent, warm in nature.Return liver, gallbladder, stomach warp.There is soothing the liver dispelling the stagnated QI, the merit that removing food stagnancyization is stagnant.For distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food.The dry mature skin of Fructus Citri tangerinae and variety thereof is containing volatile oil 1.198%-3.187%, and wherein main constituent is limonene, beta-myrcene, a-and nopinene, a-terpinene, a-thujene, sabinene, octanal etc.There is boosting, Antishock function, make smooth muscle excited, have significant spasmolysis; Contained volatile oil has phlegm-dispelling functions, and its effective ingredient is limonene.
External-applied ointment compositions of the present invention can be made the exterior-applied formulations such as emplastrum, plaster, gel, ointment, liniment, by the topical administration mode such as sticking, smear, uses.
Wherein, the step that described external-applied ointment compositions is carried out is in the following order prepared from:
1) according to following weight portion proportioning, prepare raw material
Radix Rehmanniae 20-40, Radix Ampelopsis 20-35, Rhizoma Drynariae 20-45, Radix Notoginseng 25-60, Semen Persicae 20-40, Radix Rehmanniae Preparata 10-25, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-35, Cortex Cinnamomi 20-30, Radix Angelicae Dahuricae 20-45, Radix Angelicae Sinensis 20-35, Radix Paeoniae Rubra 25-45, Rhizoma Et Radix Notopterygii 15-30, Radix Sophorae Flavescentis 15-35,, Radix Glycyrrhizae 15-25, Radix Angelicae Pubescentis 15-30, Radix Scrophulariae 15-35, Radix Et Rhizoma Rhei 10-25, Semen Momordicae 20-45, Plumbum preparatium 20-45, Semen Cucumidis sativi 10-25, leek seed 20-30, Semen Vitis viniferae 20-30, Pericarpium Citri Reticulatae Viride 30-50;
2) the raw material Radix Rehmanniae, Radix Ampelopsis, Rhizoma Drynariae, Radix Notoginseng, Semen Persicae, Radix Rehmanniae Preparata, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei, Semen Momordicae are pulverized to rear mix homogeneously, make the first compound;
3) raw material Semen Cucumidis sativi, leek seed, Semen Vitis viniferae, Pericarpium Citri Reticulatae Viride are pulverized respectively, made cucumber seed powder, leek seed powder, Semen Vitis viniferae powder, Pericarpium Citri Reticulatae Viride powder;
4) the first compound is joined in Oleum sesami, carry out heating extraction, filter, collect oily extracting solution;
5) in oily extracting solution, add Plumbum preparatium, stirring and evenly mixing;
6) then add successively cucumber seed powder, leek seed powder, Semen Vitis viniferae powder, stir;
7) add Pericarpium Citri Reticulatae Viride powder, stir and get final product.
Particularly, the weight portion proportioning of raw material described in step 1) is: Radix Rehmanniae 25-30, Radix Ampelopsis 25-30, Rhizoma Drynariae 25-30, Radix Notoginseng 25-40, Semen Persicae 20-30, Radix Rehmanniae Preparata 15-25, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-30, Cortex Cinnamomi 25-30, Radix Angelicae Dahuricae 25-35, Radix Angelicae Sinensis 20-30, Radix Paeoniae Rubra 25-30, Rhizoma Et Radix Notopterygii 20-30, Radix Sophorae Flavescentis 25-30, Radix Glycyrrhizae 20-25, Radix Angelicae Pubescentis 20-30, Radix Scrophulariae 20-30, Radix Et Rhizoma Rhei 15-25, Semen Momordicae 20-35, Plumbum preparatium 25-40, Semen Cucumidis sativi 15-25, leek seed 25-30, Semen Vitis viniferae 20-25, Pericarpium Citri Reticulatae Viride 40-50; Step 2) granularity described in after raw material pulverizing is 200-300 order; Granularity described in step 3) after raw material pulverizing is 200-500 order; The first compound described in step 4) is 400-900:2500 with the ratio of the weight of Oleum sesami, is preferably 600-700:2500; The step 4) heating extraction time is 2-10 hour, is preferably 5-6 hour; Heating extraction temperature is 150-500 ℃, is preferably 300-400 ℃, more preferably 350-400 ℃.
Particularly, step 4) also comprises described the first compound is joined and in Oleum sesami, carries out immersion treatment, and then carries out described heating extraction and process.
Especially, the ratio of the weight of the first compound described in described immersion treatment process and the weight of the Oleum sesami adding is 400-900:2500, is preferably 600-700:2500; Soak time is 3-7 days; Soaking temperature is 10-35 ℃.
When external-applied ointment compositions prepared by the present invention is used, before sticking, with Blowing drum or fire heat fused, stick on corresponding acupuncture point, 8-24 hour/paste, 7-15 gram of every subsides (crude drug), were used after 3-30 days continuously, can blood circulation promoting and blood stasis dispelling, granulation promoting, toxin expelling, draw out the pus.During use, according to theory of Chinese medical science point selection treatment based on syndrome differentiation, make local passages through which vital energy circulates unobstructed, QI and blood is in harmonious proportion, thereby inflammatory symptom is disappeared and heals.Traditional Chinese medicine external patch, makes the straight deep tissue thoroughly of medicine, can increase local blood circulation, reduces inflammatory exudation, promotes dissipation and the absorption of inflammatory edema, its inflammatory symptoms is eliminated, functional rehabilitation.
External-applied ointment compositions tool prepared by the present invention has the following advantages:
1, the present invention excavated external Chinese medicament composite cream for the preparation of the medical value that prevents and/or treats skin trauma medicine, be applied to treat skin trauma, promote the evident in efficacy of skin healing.
2, campaign of the present invention studies have shown that external-applied ointment of the present invention has the effect of significant prevention and treatment skin trauma, determined curative effect, and the skin injury that a variety of causes is caused and skin ulcer all have clear improvement and therapeutic effect; Total effective rate to decubital ulcer reaches 87.7%; The sores ulceration of skin that diabetes are caused, the total effective rate of skin injury are 95.3%; The total effective rate of the sores ulceration of skin that vascular conditions is caused is 89.9%; The total effective rate of the sores ulceration of skin that opponent's postoperative wound does not more cause is 84.6%; The total effective rate of the sores ulceration of skin dark to trauma wounds, wound surface rots to cause is 99.0%; The total effective rate of the sores ulceration of skin that chilblain is caused is 90.0%.Can significantly improve every sings and symptoms of various chronic skin skin infection, and in use procedure, have no obvious untoward reaction.
3, the present invention uses the plaster dosage form of external-applied ointment, adopted different animal models, by sticking approach, carried out a large amount of animal experiments, result of the test shows: (1) external-applied ointment compositions of the present invention can significantly reduce redness and the edema after skin injury, promotes skin wound healing; (2) can promote the healing of wound face after burn, shorten the incrustation time, the time is dug in incrustation and the decrustation time all significantly shortens, scald wound area reducing, and wound healing time is short, and the healing of the skin of burn is had to obvious facilitation; (3) to skin without any stimulation; (4) can significantly suppress rat auricle swelling degree due to xylol, inhibitory rate of intumesce is high, has significant antiinflammatory action.
4, the pharmacological action of external-applied ointment of the present invention is strong, be used for the treatment of and to improve the effect of skin trauma remarkable, instant effect, toxic and side effects is little, safety good, can long-term taking, external-applied ointment compositions of the present invention adopts and sticks affected part, and medicine is directly acted on to diseased region, targeting is strong, avoid the side effect such as drug-induced gastrointestinal irritation, and available its antiinflammatory of modern pharmacology Epidemiological Analysis, granulation promoting mechanism, good prospect in medicine there is.
5, abundant, inexpensive, the clinical use safety in products material of the present invention source, preparation technology is simple, can be made into various dosage forms, and consumption is little, easy to use, is therefore easy to promote.
6, external Chinese medicament composite cream of the present invention is for the pathogenic factor symptomatic treatment of skin trauma, the present composition is composited by plurality of Chinese composition, the active component of medicine wherein, synergism, directly for the cause of disease, takes too many levels Comprehensive Treatment for the various formation reasons of the skin incurring loss mutually, cure in the source forming from skin trauma, the compound medicine of preparing many target treatments, therapeutic effect is fast, and effect is rapidly.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.But these embodiment only limit to the present invention is described, be not used in and limit the scope of the invention.The experimental technique of unreceipted specific experiment condition in the following example, conventionally according to normal condition, or the condition of advising according to manufacturer.
By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples have comprised the pharmacodynamics test of medicine of the present invention.
The effect clinical observation of test example 1 external-applied ointment compositions treatment of the present invention burn
(1) physical data:
External-applied ointment compositions of the present invention (plaster) is observed the therapeutic effect of understanding 150 routine fire victims in outpatient service.
In trier, patient age is between 20-67 year, wherein patient's 71 examples of I degree burn; Patient's 42 examples of Superficial bums; Patient's 32 examples of deepⅱdegreeburn; Patient's 5 examples of III degree burn.All patients is all accepted the made plaster of external-applied ointment compositions of the embodiment of the present invention 1 preparation, carries out topical therapeutic, observes wound healing situation.
(2) burn and scald III degree quartering clinical criteria:
(1), I degree (erythema burn and scald): epidermis is complete, red, shows to be dried, and without oozing out or vesicle, local swelling is not remarkable, and desquamation healing after 3-5 days, without cicatrix;
(2), light degree Ⅱ (vesicle burn and scald): have obvious vesicle, the de-rear wound of the epidermis end is red, wet, local swollen, and as nothing infects, healing in 10-14 days, does not leave over cicatrix, but may have pigment alteration by skin after healing, can recover later;
(3), dark II degree: outward appearance is swollen, and epidermis bois de rose, often loses vesicle, and the micro-tide of removing the necrotic tissue skin depth wound substrate is red and white, can heal, often leave over cicatrix for general 3 weeks;
(4), III (holostrome skin burn): wound surface is dry, and different according to burn and scald degree, it is white that wound surface can show wax, and brown or carbonization is hindered district's edema obvious, nonelastic, leather sample, Pi Wen is low.General III degree empyrosis wound surface needs skin-grafting healing without the basis of regeneration skin, leaves over serious cicatrix.
(3) using method:
Get this external-applied ointment compositions appropriate, after heat fused, stick on affected part, every subsides stick 8-12 hour, it within 10 days, is 1 course for the treatment of, use 3 courses for the treatment of continuously, anemia of pregnant woman's forbidding, dark II degree and III degree fire victim oral antibiotic 3 days, respectively arrange 10 examples to I degree, light degree Ⅱ and deepⅱdegreeburn patient and after giving conventional debridement treatment, apply compound recipe Oleum Radix Arnebiae (Oleum Radix Lithospermi) (the accurate word Z20044385 of traditional Chinese medicines the same period, Suizhou Pharmaceutical Co., Ltd., Jianmin Group, Wuhan City, every bottled 30ml) routine in contrast, to carry out check analysis.III degree fire victim, because be in a bad way, does not arrange contrast.
(4) therapeutic outcome
All data all applicable SPSS11.5 software are carried out statistical analysis, and therapeutic outcome is as shown in table 1.
The therapeutic outcome of table 1 external-applied ointment of the present invention to burn
Result shows:
1, the clinical treatment result demonstration that above-mentioned 150 examples are suffered from, external-applied ointment compositions of the present invention can significantly shorten the healing time of I degree, light degree Ⅱ, dark II degree and III degree wound surface of burn patients, and pain relieving rapidly, and pain relieving time obviously shortens; Burn wound part is without secondary infection, and local inflammation (red, swollen, hot, pain etc.) day by day alleviates, and after wound healing, non-pigment is calm, and skin surface is smooth, and the 26S Proteasome Structure and Function of skin is good, even if leave cicatrix, cicatrix area is significantly less than wound surface area.
2, the determined curative effect of external-applied ointment compositions treatment burn of the present invention, remarkable to remission and the therapeutic effect of burn, and before and after treatment, symptom obviously disappears or improves.External-applied ointment compositions of the present invention is easy to use, in use has no obvious adverse reaction and the stimulation to skin.
The Clinical efficacy of test example 2 external-applied ointment compositions treatment of the present invention chronic skin skin infection
(1) physical data:
External-applied ointment compositions of the present invention (plaster) from December, 1997 to 2010 year by the end of December, observes through 658 examples the effects of understanding treatment chronic skin skin infection altogether.
Chronic skin skin infection patient age 40-78 year, wherein, diabetic skin skin infection patient 150 examples; Sores ulceration of skin patient 79 examples that vascular conditions causes; Sores ulceration of skin patient 52 examples that hands postoperative wound does not more cause; Sores ulceration of skin patient 200 examples that trauma wounds is dark, wound surface rots to cause; Sores ulceration of skin patient 120 examples that chilblain causes; Sores ulceration of skin patient 57 examples that decubital ulcer causes.All patients is all accepted the made plaster of external-applied ointment compositions of the embodiment of the present invention 1 preparation, carries out topical therapeutic, observes wound healing situation.
Various chronic skin skin infection patients, except chilblain patient, are divided three classes according to the size of its wound surface above, category-A: wound surface area <5cm * 5cm; Category-B: wound surface area >5cm * 5cm and <10cm * 10cm; C class: wound surface area >10cm * 10cm.Chilblain patient is divided into two classes according to wound surface size: category-A: wound surface area <2cm * 2cm; Category-B: wound surface area >2cm * 2cm and <3cm * 3cm.
(2) Therapeutic Method
Get this external-applied ointment compositions appropriate, stick in affected part after heat fused, every subsides stick 8-12 hour, within 15 days, are 1 course for the treatment of, use continuously 3 courses for the treatment of.
(3)) curative effect judging standard
Cure: sores ulceration of skin area significantly dwindles, inflammation disappears, and skin infection area reduces >1/3, does not produce new wound surface;
Effective: sores ulceration of skin area dwindles gradually, inflammation disappears, and skin infection area reduces≤1/3, does not produce new wound surface;
Invalid: sores ulceration of skin area, inflammation are without significant change.
(4) therapeutic outcome
External-applied ointment of the present invention is as shown in table 2 on the impact of the wound healing patient's of chronic skin skin infection healing time, and data all applicable SPSS11.5 software are carried out statistical analysis;
The impact of table 2 external-applied ointment of the present invention on the wound healing time of chronic skin skin infection
Therapeutic outcome to chronic skin skin infection is as shown in table 3.
The therapeutic outcome of table 3 external-applied ointment of the present invention to chronic skin skin infection
Table 2,3 experimental result show:
1, external-applied ointment treatment chronic skin skin infection effect of the present invention is remarkable, and wound healing time is short, and wound surface skin texture and function after healing are good, in use have no obvious adverse reaction and the stimulation to skin.
2, the sores ulceration of skin that external-applied ointment compositions of the present invention causes diabetes, the total effective rate of skin injury are 95.3%; The total effective rate of the sores ulceration of skin that vascular conditions is caused is 89.9%; The total effective rate of the sores ulceration of skin that opponent's postoperative wound does not more cause is 84.6%; The total effective rate of the sores ulceration of skin dark to trauma wounds, wound surface rots to cause is 99.0%; The total effective rate of the sores ulceration of skin that chilblain is caused is 90.0%; The total effective rate of the sores ulceration of skin that decubital ulcer is caused is 87.7%.Illustrate that external-applied ointment of the present invention has significant curative effect to treatment chronic skin skin infection.
Test example 3 external-applied ointment compositionss cause the impact of rat auricle inflammation on rat xylol
3.1 experiment material
SPF level rat, female, body weight 180～200g, is provided quality certification numbering: SCXK (capital) 2009-0009 by dimension tonneau China's zoopery center.
The external Chinese medicinal ointment of embodiment 1 preparation, makes emplastrum, and external, is affixed on affected part, and each one pastes, once a day.
Positive control medicine: indomethacin ointment, Shenyang City Xing Qi Pharmaceutical Co, specification 1%, external, is applied to affected part in right amount.
3.2 experimental technique
Get 60 of rats, be divided at random 6 groups, be blank group, model control group (smearing deionized water 5mL/kg), external-applied ointment of the present invention combination object height (10g crude drug/kg), in (5g crude drug/kg), low (2g crude drug/kg) dosage group, positive drug matched group, 10 every group.Deionized water, external-applied ointment of the present invention, indomethacin ointment are coated in to rat auris dextra two sides, every day 2 times, after successive administration 7 days, after last administration 30min, except blank group is smeared deionized water 0.1ml/ in rat auris dextra two sides, other each groups are smeared dimethylbenzene (analytical pure) 0.1ml/ and are only caused swollenly in rat auris dextra two sides, left ear is not smeared as normal ear.After 5h, de-cervical vertebra is put to death rat, sweeps away the disk at the same position of ear, left and right with card punch, on balance, weighs, and it is swelling that auris dextra weight deducts left ear weight, the antiinflammatory action of comparative drug, and result is carried out statistical analysis, and calculates swelling suppression ratio.
Inhibitory rate of intumesce (%)=(the average swelling of the average swelling-administration of model control group group) average swelling * 100% of/model control group
Data processing method is carried out t check or variance analysis by SPSS13.0 statistical analysis software.Measurement result is as shown in table 4.
The impact of rat auricle edema due to table 4 medicine xylol of the present invention (n=10,
)
| ? | Swelling (mg) | Inhibitory rate of intumesce (%) |
| Blank group | 0.12±2.31** | - |
| Model control group | 8.79±0.39 | - |
| Positive drug matched group | 5.47±1.79** | 37.77 |
| Medicine high dose group of the present invention | 5.24±1.62** | 40.39 |
| Dosage group in medicine of the present invention | 6.10±1.78** | 30.60 |
| Medicine low dose group of the present invention | 6.99±1.57** | 20.48 |
With model control group comparison, * * p < 0.01
From the testing result of table 4, positive drug indomethacin ointment group xylol causes rat auricle edema obvious inhibitory action, compares with model control group, and auricle swelling degree has significant diversity (P<0.01); Medicine group xylol of the present invention causes rat auricle edema obvious inhibitory action, compare with model control group, medicine group auricle swelling degree of the present invention has significant diversity (P<0.01), shows that medicine of the present invention has obvious antiinflammatory action.
The impact of test example 4 external-applied ointment compositions of the present invention on rabbit skin wound healing
4.1 experiment material
Healthy New Zealand large ear rabbit, male and female half and half, body weight 2.5～3.0kg, is provided by dimension tonneau China's zoopery center.
The external Chinese medicinal ointment of embodiment 1 preparation, makes emplastrum, and external, is affixed on affected part, and each one pastes, once a day.Positive control medicine: Dextran 40 (the accurate word H41021590 of traditional Chinese medicines), He'nan Tianfang Pharmaceutical Co., Ltd.
4.2 experimental technique
Get 50 of large ear rabbits, be divided at random 5 groups, every group 10, be respectively external-applied ointment of the present invention combination object height (15.00g crude drug/kg), in (7.5g crude drug/kg), low (5g crude drug/kg) dosage group, positive drug matched group (0.3g/kg), model control group.
Before test, first with shears, cut off the hair of spinal column both sides, large ear rabbit back, with depilatory cream depilation, then with after normal saline cleaning, drying with 75% alcohol disinfecting, employing 7 after sterilization
#grinder buffing method is scratched the skin of depilation sterile zones, take oozing of blood as degree, forms rabbit skin injury model.Then administration group is the corresponding medicine of external application respectively, not administration of model control group.Successive administration 7 days.Observe and record the 1st day, 3 days, 5 days, 7 days wound healing situations of the rear administration of modeling success.
Shown in rabbit skin injury model standards of grading chart 5; External-applied ointment of the present invention is as shown in table 6 to large ear rabbit skin injury model loss therapeutic outcome.
Table 5 rabbit skin injury model standards of grading
The impact of table 6 external-applied ointment of the present invention on the healing of rabbit skin injury
From the results shown in Table 6: compare with model group, positive drug matched group and the high, medium and low dosage group of external-applied ointment compositions of the present invention all can significantly reduce red swelling of the skin and edema, promote skin wound healing.
The therapeutical effect that the dark II degree of test example 5 external-applied ointment compositions of the present invention rat is scalded
5.1 experiment material
Wistar rat, male and female half and half, body weight 350～400g, is provided by dimension tonneau China's zoopery center.
The external Chinese medicinal ointment of embodiment 1 preparation, makes emplastrum, and external, is affixed on affected part, and each one pastes, once a day.
Positive control medicine: Jingwanhong cream (the accurate word Z20023137 of traditional Chinese medicines), Tianjin Darentang Wanhong Pharmaceutical Co., Ltd, 50g:50mg.Suitable amount used externally, embrocates affected part, and one for several times.
5.2 experimental technique
The > > method of setting up of setting up edematous fluid collection animal model under > > (nursing research, the 17th the 6th phase of volume of June in 2003) and < < scald Cavia porcellus crust according to the people's such as Zhang Liying < < Wistar rat II degree scalding model carry out this test.
After ether inhalation anesthesia, with the back of all rats of razor scraping, and slough hair with depilatory cream, then with normal saline, clean, after dry, with 75% alcohol disinfecting, get a 3cm * 3cm, in the gauze immersion hot water that thickness is 2mm, after water boiling, when temperature constant is 100 ℃, rapidly gauze is removed, be laid on the skin after the depilation of rat back, gauze, from the timing immediately of contact rat skin, after 10 seconds is removed gauze.Rat back is each side scalded a place, with reference to next standard, judges scald degree.
Burn and scald III degree quartering clinical criteria:
(1), I degree (erythema burn and scald): epidermis is complete, red, dry tack free, without oozing out or vesicle, local swelling is not remarkable, desquamation healing after 3-5 days, without cicatrix;
(2), light degree Ⅱ (vesicle burn and scald): have obvious vesicle, the de-rear wound of the epidermis end is red, wet, local swollen, and as nothing infects, healing in 10-14 days, does not leave over cicatrix, but may have pigment alteration by skin after healing, can recover later;
(3), dark II degree: outward appearance is swollen, and epidermis bois de rose, often loses vesicle, and the micro-tide of removing the necrotic tissue skin depth wound substrate is red and white, can heal, often leave over cicatrix for general 3 weeks;
(4), III (holostrome skin burn): wound surface is dry, and different according to burn and scald degree, it is white that wound surface can show wax, and brown or carbonization is hindered district's edema obvious, nonelastic, leather sample, Pi Wen is low.General III degree empyrosis wound surface needs skin-grafting healing without the basis of regeneration skin, leaves over serious cicatrix.
Select 40 consistent of dark II degree After Scalding In Rats of active state to test, be divided at random 4 groups, 10 every group, wherein Jingwanhong cream is smeared in the affected part, left side of 10, and one for several times, as positive drug matched group; The left side of 10 sticks external-applied ointment compositions of the present invention (15.00g crude drug/kg), as high dose group of the present invention; The left side of 10 sticks external-applied ointment compositions of the present invention (7.50g crude drug/kg), as dosage group in the present invention; The left side of 10 sticks external-applied ointment compositions of the present invention (5.00g crude drug/kg), as low dose group of the present invention.The high, medium and low dosage group of external-applied ointment of the present invention rat is administered once every day, continuously 7-15 days.All not administrations of right side of all rats.
Rat normal diet in process of the test, result of the test is as shown in table 7.
The impact of table 7 external-applied ointment of the present invention on the dark II degree of rat scalding model
| ? | The incrustation time (my god) | Incrustation dig the time (my god) | The decrustation time (my god) |
| Model control group | 6 | 13 | 20 |
| Positive drug matched group | 5 | 10 | 18 |
| Medicine high dose group of the present invention | 3 | 7 | 10 |
| Dosage group in medicine of the present invention | 4 | 8 | 12 |
| Medicine low dose group of the present invention | 5 | 9 | 15 |
From the results shown in Table 7: ointment composition of the present invention can promote to scald the healing of rear wound face, shorten the incrustation time, the time is dug in incrustation and the decrustation time all significantly shortens, scald wound area reducing, the therapeutic effect that the dark II degree of rat is scalded is remarkable, to scalding the healing of the skin in affected part, has obvious facilitation.
The impact of test example 6 external-applied ointment compositions of the present invention on skin of diabetic rats damage
6.1 experiment material
Wistar rat, male and female half and half, body weight 350～400g, is provided by dimension tonneau China's zoopery center.
The external Chinese medicinal ointment of embodiment 1 preparation, makes emplastrum, and external, is affixed on affected part, and each one pastes, once a day.Within 30 days, be a course for the treatment of, use continuously 3 courses for the treatment of.
Positive control medicine: mupirocin ointment (the accurate word H10930064 of traditional Chinese medicines), Sino-America Tianjin Shike Pharmaceutical Co., Ltd., 2%, external, part is applied to affected part, every day three times, five days courses for the treatment of, can repeat a course for the treatment of if desired, and affected part can or cover with dressing wrapping.
6.2 experimental technique
Get 50 of rats, under ether inhalation anesthesia, will be dissolved in the afterbody of the streptozotocin intravenous injection of citrate buffer solution to rat, every rat injected dose is 80mg/kg.After intravenous injection 4 weeks, after ether inhalation anesthesia, with the back of all rats of razor scraping, and slough hair with depilatory cream.After 24h, with normal saline, clean, after dry, with 75% alcohol disinfecting, the skin biopsy that is then 5mm with diameter use trepan scratches rat skin 5 places with equal intervals on rat back skin, and wound injures epidermis and corium, and have hemorrhagely on a small quantity, make the diabetes rat of skin injury.
The diabetes rat of skin injury is divided into 5 groups at random, model control group, positive drug matched group, external-applied ointment compositions of the present invention stick height (15.00g crude drug/kg), in (7.5g crude drug/kg), low (3g crude drug/kg) dosage group.Model control group is left intact, and corresponding ointment is smeared or sticked to all the other each groups in rat back cutaneous lesion.Before set time every day, (8 a.m. to 8 is between thirty) applied ointment for the first time, back wound is taken a picture, and measure their area.The skin trauma area estimation result of diabetes rat is as shown in table 8.
The impact of table 8 external-applied ointment of the present invention on skin of diabetic rats damage
From the results shown in Table 8: the high, medium and low dosage group of ointment composition of the present invention is compared with model control group, has significant difference, show that ointment composition of the present invention has obvious therapeutical effect to the skin injury of diabetes rat.
The skin irritation test of test example 7 external-applied ointment compositions of the present invention
7.1 experiment material
Healthy New Zealand large ear rabbit, male and female half and half, body weight 2.5～3.0kg, is provided by dimension tonneau China's zoopery center.
The external Chinese medicinal ointment of embodiment 1 preparation, makes emplastrum, and external, is affixed on affected part, and each one pastes, once a day.
7.2 experimental technique
Before test, the hair of 4 family's rabbit back spinal column both sides is cut off, with depilatory cream depilation, then with after normal saline cleaning, drying with 75% alcohol disinfecting.Using the depilation district skin on all rabbit depilations posterior spinal right side as normal skin irritant test district, the depilation district skin in left side is drawn to " # " type with 11# sharp knife on depilation district skin to be scratched, as injured skin irritant test district, sharp knife is stabbed epidermis, oozing of blood, but do not injure corium, the diameter 2cm of wound.
Normal skin, injured skin irritant test district are divided into respectively to administration district and check plot, and administration district sticks the plaster that external Chinese medicinal ointment of the present invention is made; Normal saline is smeared in check plot, uses immobilization with adhesive tape, once a day after then covering with gauze.After administration 24h, the medicine on clearing skin surface, observes redness, edematous condition that administration district and position, check plot occur.
7.3 experimental result
The evaluation criteria of skin irritation reaction:
Non-stimulated (-): without abnormal finding;
Slight stimulate (+): congested, erythema;
Moderate stimulates (++) erythema, a small amount of petechia, edema, and a small amount of blood rash, phlysis form;
Serious stimulation (+++): redness, subcutaneous hemorrhage, edema, phlysis merge large vesicle, erosion, ulcer.
Skin irritation result of the test is as shown in table 9.
Table 9 external-applied ointment of the present invention is tested rabbit skin irritation
Result of the test shows that external Chinese medicament composite cream of the present invention has no stimulation to skin.
Test example 8 external-applied ointment compositions of the present invention clinical pharmacology, toxicological test
(1) acute toxicity test
External-applied ointment composition plaster of the present invention agent is sticked to 500g(crude drug to kunming mice)/kg.Do not occur any toxic reaction, one week interior without animal dead.
(2) long term toxicity test
External-applied ointment compositions of the present invention is carried out to long term toxicity test to rat, continuously heavy dose of (adult's dosage 100 times) sticks administration, administration time long (90 days), general performance, body weight, food ration, hematology and Biochemical Indices In Serum, routine urinalysis, bone marrow classification, organ weights, the organ coefficient of take before and after animals administer are to detect index, and be aided with the pathological examination that animal is respectively organized internal organs, the toxicity situation of overall merit medicine.Result shows that the indices of rat is all normal.Histopathologic examination's result demonstration, rat is respectively organized internal organs no abnormality seen.
In sum: external-applied ointment compositions toxicity of the present invention is low, and safety range is wide.
Embodiment 1
1) according to following proportioning, take raw material (unit: * 100g)
The Radix Rehmanniae 25, Radix Ampelopsis 25, Rhizoma Drynariae 25, Radix Notoginseng 25, Semen Persicae 25, Radix Rehmanniae Preparata 25, the Pseudobulbus Bletillae (Rhizoma Bletillae) 25, Cortex Cinnamomi 25, the Radix Angelicae Dahuricae 25, Radix Angelicae Sinensis 25, Radix Paeoniae Rubra 25, Rhizoma Et Radix Notopterygii 25, Radix Sophorae Flavescentis 25, Radix Glycyrrhizae 25, Radix Angelicae Pubescentis 25, Radix Scrophulariae 25, Radix Et Rhizoma Rhei 25, Semen Momordicae 25, Plumbum preparatium 25, Semen Cucumidis sativi 25, leek seed 25, Semen Vitis viniferae 25, Pericarpium Citri Reticulatae Viride 50
Wherein, the Radix Rehmanniae, Radix Ampelopsis, Rhizoma Drynariae, Radix Notoginseng, Semen Persicae, Radix Rehmanniae Preparata, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei, Semen Momordicae are ground into fine powder, powder particle size is 200-300 order, mix homogeneously, makes after the first fine powder mixture standby;
By raw material Semen Cucumidis sativi, leek seed, Semen Vitis viniferae, Pericarpium Citri Reticulatae Viride difference crushing fine powder, make cucumber seed powder, leek seed powder, Semen Vitis viniferae powder, Pericarpium Citri Reticulatae Viride powder, powder particle size is 200-500 order.
2) the first fine powder mixture of mix homogeneously is placed in to Multifunctional Chinese medicine and extracts still, then add Oleum sesami, under room temperature (15-30 ℃), carry out immersion treatment, wherein, the immersion treatment time is 3 days, and the weight of the first fine powder mixture is 600:2500 with the ratio of the weight of the Oleum sesami adding;
3) open multi-functional extraction still power supply and heat, be heated to 350 ℃, remain on constant temperature at this temperature and extract 6 hours, then filter, obtain sesame oil extraction liquid standby;
4) in sesame oil extraction liquid, add Plumbum preparatium, stirring and evenly mixing;
5) then add successively cucumber seed powder, leek seed powder, Semen Vitis viniferae powder, stir;
6) add Pericarpium Citri Reticulatae Viride powder, stir and get final product.
During use, ointment is heated, treat that it melts, with being coated with cream rod, dip in appropriate plaster, spread upon on non-woven fabrics, stick on ailing relevant acupuncture point and maybe the non-woven fabrics of smearing plaster is packed in closing bag, face the used time and take out, after the thawing of heating, use.
Embodiment 2
1) according to following proportioning, take raw material (unit: * 100g)
The Radix Rehmanniae 20, Radix Ampelopsis 30, Rhizoma Drynariae 30, Radix Notoginseng 40, Semen Persicae 20, Radix Rehmanniae Preparata 15, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20, Cortex Cinnamomi 30, the Radix Angelicae Dahuricae 35, Radix Angelicae Sinensis 30, Radix Paeoniae Rubra 45, Rhizoma Et Radix Notopterygii 20, Radix Sophorae Flavescentis 30, Radix Glycyrrhizae 25, Radix Angelicae Pubescentis 20, Radix Scrophulariae 15, Radix Et Rhizoma Rhei 25, Semen Momordicae 35, Plumbum preparatium 20, Semen Cucumidis sativi 10, leek seed 30, Semen Vitis viniferae 30, Pericarpium Citri Reticulatae Viride 30
Wherein, the Radix Rehmanniae, Radix Ampelopsis, Rhizoma Drynariae, Radix Notoginseng, Semen Persicae, Radix Rehmanniae Preparata, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei, Semen Momordicae are ground into fine powder, powder particle size is 200-300 order, mix homogeneously, makes after the first fine powder mixture standby;
By raw material Semen Cucumidis sativi, leek seed, Semen Vitis viniferae, Pericarpium Citri Reticulatae Viride difference crushing fine powder, make cucumber seed powder, leek seed powder, Semen Vitis viniferae powder, Pericarpium Citri Reticulatae Viride powder, powder particle size is 200-500 order;
2) the first fine powder mixture of mix homogeneously is placed in to Multifunctional Chinese medicine and extracts still, then add Oleum sesami, under room temperature (10-30 ℃), carry out immersion treatment, wherein, the immersion treatment time is 7 days, and the weight of the first fine powder mixture is 605:2500 with the ratio of the weight of the Oleum sesami adding;
3) open multi-functional extraction still power supply and heat, be heated to 500 ℃, remain on constant temperature at this temperature and extract 2 hours, then filter, obtain sesame oil extraction liquid standby;
4) in sesame oil extraction liquid, add Plumbum preparatium, stirring and evenly mixing;
5) then add successively cucumber seed powder, leek seed powder, Semen Vitis viniferae powder, stir;
6) add Pericarpium Citri Reticulatae Viride powder, stir and get final product.
Embodiment 3
1) according to following proportioning, take raw material (unit: * 100g)
The Radix Rehmanniae 30, Radix Ampelopsis 35, Rhizoma Drynariae 20, Radix Notoginseng 60, Semen Persicae 30, Radix Rehmanniae Preparata 10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 35, Cortex Cinnamomi 20, the Radix Angelicae Dahuricae 20, Radix Angelicae Sinensis 35, Radix Paeoniae Rubra 30, Rhizoma Et Radix Notopterygii 15, Radix Sophorae Flavescentis 15, Radix Glycyrrhizae 15, Radix Angelicae Pubescentis 30, Radix Scrophulariae 35, Radix Et Rhizoma Rhei 10, Semen Momordicae 45, Plumbum preparatium 40, Semen Cucumidis sativi 15, leek seed 20, Semen Vitis viniferae 20, Pericarpium Citri Reticulatae Viride 40
Wherein, the Radix Rehmanniae, Radix Ampelopsis, Rhizoma Drynariae, Radix Notoginseng, Semen Persicae, Radix Rehmanniae Preparata, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei, Semen Momordicae are ground into fine powder, powder particle size is 200-300 order, mix homogeneously, makes after the first fine powder mixture standby;
By raw material Semen Cucumidis sativi, leek seed, Semen Vitis viniferae, Pericarpium Citri Reticulatae Viride difference crushing fine powder, make cucumber seed powder, leek seed powder, Semen Vitis viniferae powder, Pericarpium Citri Reticulatae Viride powder, powder particle size is 200-500 order;
2) the first fine powder mixture of mix homogeneously is placed in to Multifunctional Chinese medicine and extracts still, then add Oleum sesami, under room temperature (20-30 ℃), carry out immersion treatment, wherein, the immersion treatment time is 4 days, and the weight of the first fine powder mixture is 625:2500 with the ratio of the weight of the Oleum sesami adding;
3) open multi-functional extraction still power supply and heat, be heated to 150 ℃, remain on constant temperature at this temperature and extract 10 hours, then filter, obtain sesame oil extraction liquid standby;
4) in sesame oil extraction liquid, add Plumbum preparatium, stirring and evenly mixing;
5) then add successively cucumber seed powder, leek seed powder, Semen Vitis viniferae powder, stir;
6) add Pericarpium Citri Reticulatae Viride powder, stir and get final product.
Embodiment 4
1) according to following proportioning, take raw material (unit: * 100g)
The Radix Rehmanniae 40, Radix Ampelopsis 20, Rhizoma Drynariae 45, Radix Notoginseng 25, Semen Persicae 40, Radix Rehmanniae Preparata 25, the Pseudobulbus Bletillae (Rhizoma Bletillae) 30, Cortex Cinnamomi 30, the Radix Angelicae Dahuricae 45, Radix Angelicae Sinensis 20, Radix Paeoniae Rubra 25, Rhizoma Et Radix Notopterygii 30, Radix Sophorae Flavescentis 35, Radix Glycyrrhizae 20, Radix Angelicae Pubescentis 15, Radix Scrophulariae 30, Radix Et Rhizoma Rhei 15, Semen Momordicae 20, Plumbum preparatium 45, Semen Cucumidis sativi 25, leek seed 25, Semen Vitis viniferae 25, Pericarpium Citri Reticulatae Viride 50
Wherein, the Radix Rehmanniae, Radix Ampelopsis, Rhizoma Drynariae, Radix Notoginseng, Semen Persicae, Radix Rehmanniae Preparata, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei, Semen Momordicae are ground into fine powder, powder particle size is 200-300 order, mix homogeneously, makes after the first fine powder mixture standby;
By raw material Semen Cucumidis sativi, leek seed, Semen Vitis viniferae, Pericarpium Citri Reticulatae Viride difference crushing fine powder, make cucumber seed powder, leek seed powder, Semen Vitis viniferae powder, Pericarpium Citri Reticulatae Viride powder, powder particle size is 200-500 order;
2) the first fine powder mixture of mix homogeneously is placed in to Multifunctional Chinese medicine and extracts still, then add Oleum sesami, under room temperature (15-20 ℃), carry out immersion treatment, wherein, the immersion treatment time is 5 days, and the weight of the first fine powder mixture is 680:2500 with the ratio of the weight of the Oleum sesami adding;
3) open multi-functional extraction still power supply and heat, be heated to 400 ℃, remain on constant temperature at this temperature and get 6 hours, then filter, obtain sesame oil extraction liquid standby;
4) in sesame oil extraction liquid, add Plumbum preparatium, stirring and evenly mixing;
5) then add successively cucumber seed powder, leek seed powder, Semen Vitis viniferae powder, stir;
6) add Pericarpium Citri Reticulatae Viride powder, stir and get final product.
Claims (10)
1. an external-applied ointment compositions is in the application for the preparation of in treatment skin trauma medicine.
2. application as claimed in claim 1, is characterized in that described skin trauma is skin depth damage or sores ulceration of skin.
3. application as claimed in claim 1, is characterized in that described skin depth damage is damaged property skin injury; Described skin infection is skin ulcer or skin ulceration.
4. application as claimed in claim 1, is characterized in that described external-applied ointment compositions exists with emplastrum, plaster, gel, ointment, liniment form.
5. application as claimed in claim 4, is characterized in that, described emplastrum is rubber-emplastrum, cataplasma or patch; Described plaster is black plaster or white plaster.
6. application as claimed in claim 1, is characterized in that described external-applied ointment compositions is prepared from by following raw material: the Radix Rehmanniae, Radix Ampelopsis, Rhizoma Drynariae, Radix Notoginseng, Semen Persicae, Radix Rehmanniae Preparata, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei, Semen Momordicae, Plumbum preparatium, Semen Cucumidis sativi, leek seed, Semen Vitis viniferae, Pericarpium Citri Reticulatae Viride.
7. application as claimed in claim 6, is characterized in that the weight portion proportioning of described raw material is: Radix Rehmanniae 20-40, Radix Ampelopsis 20-35, Rhizoma Drynariae 20-45, Radix Notoginseng 25-60, Semen Persicae 20-40, Radix Rehmanniae Preparata 10-25, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-35, Cortex Cinnamomi 20-30, Radix Angelicae Dahuricae 20-45, Radix Angelicae Sinensis 20-35, Radix Paeoniae Rubra 25-45, Rhizoma Et Radix Notopterygii 15-30, Radix Sophorae Flavescentis 15-35, Radix Glycyrrhizae 15-25, Radix Angelicae Pubescentis 15-30, Radix Scrophulariae 15-35, Radix Et Rhizoma Rhei 10-25, Semen Momordicae 20-45, Plumbum preparatium 20-45, Semen Cucumidis sativi 10-25, leek seed 20-30, Semen Vitis viniferae 20-30, Pericarpium Citri Reticulatae Viride 30-50.
8. application as claimed in claim 1, is characterized in that the step that described external-applied ointment compositions is carried out is in the following order prepared from:
1) according to following weight portion proportioning, prepare raw material
Radix Rehmanniae 20-40, Radix Ampelopsis 20-35, Rhizoma Drynariae 20-45, Radix Notoginseng 25-60, Semen Persicae 20-40, Radix Rehmanniae Preparata 10-25, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-35, Cortex Cinnamomi 20-30, Radix Angelicae Dahuricae 20-45, Radix Angelicae Sinensis 20-35, Radix Paeoniae Rubra 25-45, Rhizoma Et Radix Notopterygii 15-30, Radix Sophorae Flavescentis 15-35,, Radix Glycyrrhizae 15-25, Radix Angelicae Pubescentis 15-30, Radix Scrophulariae 15-35, Radix Et Rhizoma Rhei 10-25, Semen Momordicae 20-45, Plumbum preparatium 20-45, Semen Cucumidis sativi 10-25, leek seed 20-30, Semen Vitis viniferae 20-30, Pericarpium Citri Reticulatae Viride 30-50;
2) the raw material Radix Rehmanniae, Radix Ampelopsis, Rhizoma Drynariae, Radix Notoginseng, Semen Persicae, Radix Rehmanniae Preparata, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei, Semen Momordicae are pulverized to rear mix homogeneously, make the first compound;
3) raw material Semen Cucumidis sativi, leek seed, Semen Vitis viniferae, Pericarpium Citri Reticulatae Viride are pulverized respectively, made cucumber seed powder, leek seed powder, Semen Vitis viniferae powder, Pericarpium Citri Reticulatae Viride powder;
4) the first compound is joined in Oleum sesami, carry out heating extraction, filter, collect oily extracting solution;
5) in oily extracting solution, add Plumbum preparatium, stirring and evenly mixing;
6) then add successively cucumber seed powder, leek seed powder, Semen Vitis viniferae powder, stir;
7) add Pericarpium Citri Reticulatae Viride powder, stir and get final product.
9. application as claimed in claim 8, is characterized in that the granularity after raw material pulverizing described in step 3) is 200-500 order.
10. application as claimed in claim 8, is characterized in that the first compound described in step 4) described in step 3) and the ratio of the weight of Oleum sesami are 400-900:2500.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310162444.0A CN104127685A (en) | 2013-05-03 | 2013-05-03 | Application of external-use plaster composition in preparation of drug used for treating skin injury |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310162444.0A CN104127685A (en) | 2013-05-03 | 2013-05-03 | Application of external-use plaster composition in preparation of drug used for treating skin injury |
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| CN104127685A true CN104127685A (en) | 2014-11-05 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535383A (en) * | 2016-02-22 | 2016-05-04 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for promoting skin wound healing and preparation method thereof |
| CN105920119A (en) * | 2016-04-29 | 2016-09-07 | 丽水市人民医院 | Traditional She medicine for treating skin injury and application method thereof |
| CN106176875A (en) * | 2016-08-26 | 2016-12-07 | 张龙元 | A kind of vulnerary compositions and preparation method |
| CN107596360A (en) * | 2017-10-10 | 2018-01-19 | 苏州浔宇新材料科技有限公司 | A kind of pharmaceutical composition for repairing scar and preparation method thereof |
| CN108853347A (en) * | 2018-09-29 | 2018-11-23 | 王士辉 | A kind of antibacterial cream of skin and its preparation method |
| CN109316555A (en) * | 2018-12-03 | 2019-02-12 | 青岛市市南区人民医院 | A kind of traditional Chinese medicine for outer use and preparation method thereof promoting chronic ulcer of skin wound healing |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1273837A (en) * | 2000-04-24 | 2000-11-22 | 傅乃新 | Black ointment |
-
2013
- 2013-05-03 CN CN201310162444.0A patent/CN104127685A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1273837A (en) * | 2000-04-24 | 2000-11-22 | 傅乃新 | Black ointment |
Non-Patent Citations (1)
| Title |
|---|
| 阙华发: "慢性皮肤溃疡的中医诊治", 《环球中医药》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535383A (en) * | 2016-02-22 | 2016-05-04 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for promoting skin wound healing and preparation method thereof |
| CN105920119A (en) * | 2016-04-29 | 2016-09-07 | 丽水市人民医院 | Traditional She medicine for treating skin injury and application method thereof |
| CN106176875A (en) * | 2016-08-26 | 2016-12-07 | 张龙元 | A kind of vulnerary compositions and preparation method |
| CN107596360A (en) * | 2017-10-10 | 2018-01-19 | 苏州浔宇新材料科技有限公司 | A kind of pharmaceutical composition for repairing scar and preparation method thereof |
| CN108853347A (en) * | 2018-09-29 | 2018-11-23 | 王士辉 | A kind of antibacterial cream of skin and its preparation method |
| CN109316555A (en) * | 2018-12-03 | 2019-02-12 | 青岛市市南区人民医院 | A kind of traditional Chinese medicine for outer use and preparation method thereof promoting chronic ulcer of skin wound healing |
| CN109316555B (en) * | 2018-12-03 | 2021-11-05 | 青岛市市南区人民医院 | External traditional Chinese medicine preparation for promoting healing of chronic skin ulcer wound and preparation method thereof |
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