CN105288096A

CN105288096A - Acne treatment drug

Info

Publication number: CN105288096A
Application number: CN201510830536.0A
Authority: CN
Inventors: 张作峰
Original assignee: Shanghai Ziyitang Biological Science & Technology Co Ltd
Current assignee: Ziyitang scar spot pox (Guangdong) skin Research Institute (L.P.)
Priority date: 2015-11-25
Filing date: 2015-11-25
Publication date: 2016-02-03
Anticipated expiration: 2035-11-25
Also published as: CN105288096B

Abstract

The present invention provides an acne treatment drug, which comprises Forsythia suspense, prunella vulgaris l, red date, hawthorn, cornus officinalis, scutellaria baicalensis, viola tricolor l, cortex phellodendri tree, potatoes, cedarwood essential oil, semen cassiae, lonicera japonica thunb, clove, piper betle l leaf, asparagus cochinchinensis, olive oil, rosmarinus officinalis essential oil, damnacanthus indicus gaertn, serissa japonica (thunb.) thunb, tribulus terrester l, herba centellae, thymus mongolicus ronn, tea tree, lemon, kadsura longipedunculata, apricot kernel oil and aloe.

Description

A kind of medicine for the treatment of comedo

Technical field

The present invention relates to a kind of medicine.More specifically, content of the present invention relates to a kind of medicine for the treatment of comedo.

Background technology

Comedo is that a kind of chronic inflammatory skin of pilosebaceous unit is sick.The factors such as main and hypersteatosis, pilosebaceous duct block, bacteriological infection and inflammatory reaction are closely related.After adolescing, in human body, the level of androgen particularly testosterone raises rapidly, promotes that sebaceous gland is grown and produces a large amount of sebum.The dyskeratosis of pilosebaceous duct causes catheter blockage, dyssebacia simultaneously, forms horn plug and micropowder thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction in hair follicle, the lipase decomposition sebum that propionibacterium acnes produces generates free fatty, chemotactic inflammatory cell and medium simultaneously, final induction also exacerbate inflammation reaction.

Present stage has the method for a lot of method removing acnes to have a lot, except some basic cleansing milk, elite breast, also has ointment, Chinese medicine etc.But these methods, have certain effect during use, but once stop using, just can recur again.Meanwhile, the product for resolving poxes of life-time service can produce certain Drug resistance, and outside life-time service, effect is very little, and treatment after, skin can exist the shortcoming such as cicatrix, corse sweat pore/

Summary of the invention

In order to solve the problem, the invention provides a kind of medicine for the treatment of comedo,

(1) prescription A, prescription B, prescription C and prescription D is comprised;

(2) extract consisting of following material of described prescription A: Fructus Forsythiae, Spica Prunellae, Fructus Jujubae, Fructus Crataegi, Fructus Corni;

(3) extract consisting of following material of described prescription B: Radix Scutellariae, Herba Violae Hortensis, Chinese corktree, Rhizoma Solani tuber osi, Cedrus deoclar (Roxb.) G. Don quintessence oil, Semen Cassiae, Flos Lonicerae, Flos Caryophylli, Folium piperis betlis;

(4) extract consisting of following material of described prescription C: Radix Asparagi, olive oil, rosemary ethereal oil, Herba Damnacanthi, Serissa foetida, Fructus Tribuli, Herba Centellae;

(5) extract consisting of following material of described prescription D: Herba thymi vulgaris, Camellia sinensis, Fructus Citri Limoniae, Radix Kadsurae longipedunculatae, almond oil, Aloe;

The medicine of described treatment comedo also comprises Mel, brown sugar and water.

In described prescription A, the parts by weight of the extract of each material in this prescription are:

Fructus Forsythiae 1-10, Spica Prunellae 1-15, Fructus Jujubae 1-20, Fructus Crataegi 1-15, Fructus Corni 1-15;

In described prescription B, the parts by weight of the extract of each material in this prescription are:

Radix Scutellariae 1-15, Herba Violae Hortensis 1-20, Chinese corktree 1-15, Rhizoma Solani tuber osi 1-5, Cedrus deoclar (Roxb.) G. Don quintessence oil 0.1-0.5, Semen Cassiae 2-15, Flos Lonicerae 5-15, Flos Caryophylli 1-10, Folium piperis betlis 1-10;

In described prescription C, the parts by weight of the extract of each material in this prescription are:

Radix Asparagi 0.1-1, olive oil 0.1-5, rosemary ethereal oil 0.1-4, Herba Damnacanthi 1-5, Serissa foetida 1-10, Fructus Tribuli 1-3, Herba Centellae 4-10;

In described prescription D, the parts by weight of the extract of each material in this prescription are:

Herba thymi vulgaris 0.1-0.9, Camellia sinensis 1-5, Fructus Citri Limoniae 0.1-1, Radix Kadsurae longipedunculatae 1-15, almond oil 5-15, Aloe 3-8.

Fructus Forsythiae 2-8, Spica Prunellae 5-10, Fructus Jujubae 5-15, Fructus Crataegi 5-10, Fructus Corni 8-12;

Radix Scutellariae 4-10, Herba Violae Hortensis 10-15, Chinese corktree 5-10, Rhizoma Solani tuber osi 1-3, Cedrus deoclar (Roxb.) G. Don quintessence oil 0.1-0.3, Semen Cassiae 5-10, Flos Lonicerae 5-10, Flos Caryophylli 2-8, Folium piperis betlis 3-7;

Radix Asparagi 0.1-0.8, olive oil 0.1-3, rosemary ethereal oil 0.1-2, Herba Damnacanthi 1-3, Serissa foetida 2-8, Fructus Tribuli 1-2, Herba Centellae 5-8;

Herba thymi vulgaris 0.1-0.7, Camellia sinensis 1-4, Fructus Citri Limoniae 0.1-0.8, Radix Kadsurae longipedunculatae 5-10, almond oil 5-10, Aloe 3-6.

The extracting method of described Flos Lonicerae extract, Chinese corktree extract, Herba Centellae extract is: clean, and chopping, first uses the explosion of airblasting method, then use acetic acid reflux, extract, 3-5 time, merge extractive liquid, vacuum drying, to obtain final product.

The extracting method of Suo Shu Folium piperis betlis extract, Herba Damnacanthi extract, Radix Kadsurae longipedunculatae extract is: clean, chopping, and refined honey mixing post-heating is to 45-65 DEG C, and insulation 3-5h, using water as solvent after cooling, use ultrasonic extraction 3-6h, vacuum drying extracting solution, to obtain final product.

The extracting method of described Radix Scutellariae extract, Fructus Forsythiae extract, Spica Prunellae extract, Fructus Jujubae extract, Fructus Crataegi extract, Radix Scutellariae extract, Fructus Corni extract, Semen Cassiae extract, Radix Asparagi extract is: clean, chopping, first use the explosion of airblasting method, with alcohol reflux again 3-5 time, merge extractive liquid.

The extracting method of described Flos Caryophylli extract, Poria extract, Thymi Serpylli Herba extract is: using water as solvent, use ultrasonic extraction 3-6h.

The extracting method of described Serissa foetida extract, Fructus Tribuli extract, tea tree extract, almond oil extract is: clean, and Testa Tritici fries 0.5-1h, and temperature is 120-130 DEG C, filters Testa Tritici after cooling, and chopping, using ethanol as solvent, uses ultrasonic extraction 3-6h.

Described Cedarwood extract, Herba Violae Hortensis extract, Herba Rosmarini Officinalis extract, Aloe extract are obtained by supercritical carbon dioxide extraction, and extraction temperature is 30-35 DEG C, and extracting pressure is 18-25MPa, and resolution temperature is 42-53 DEG C, and parsing pressure is 5-7MPa.

Prepare a medicine for described treatment comedo, the product cyclodextrin derivative of prescription C and prescription D carries out enclose, then the prescription C after enclose and prescription D and prescription B is carried out polylactic acid enclose, finally mixes with prescription A.

component A:

fructus Forsythiae.property bitter, cool." herbal classic ": bitter in the mouth, flat." not Lu ": nontoxic." medicine origin ": " curing mainly secret formula " cloud, cool in nature, bitter in the mouth.Compendium of Material Medica: micro-toil.

Enter the heart, liver, gallbladder meridian.Materia Medica of Decoction: the few sun of brothers, Yangming Channel." detailed outline ": few cloudy heart channel, Yinpao (Liv 9) network edema caused by disorder of QI of fainting." Thunder God concocts property of medicine solution ": enter the heart, liver, gallbladder, stomach, three burnt, large intestine the six channels.

" herbal classic ": " main cold and heat, Mus flaccidity, scrofula, carbuncle malignant boil, goiter, stagnation of pathogenic heat." " not Lu ": " removes tapeworm." " property of medicine opinion ": " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat." " Japan hanako materia medica ": " leads to small intestinal, evacuation of pus.Control furuncle, pain relieving, logical menstruation." Li Gao: " loose all menses stagnation of QI gather; Detumescence." Wang Haogu: " controls deaf Hun Hun Jun Jun."

The chemical composition of Fructus Forsythiae: fruit is containing Neolignans: forsythin, phillygenin, dextrorotation pinoresinol, dextrorotation (+)-Pinoresinol glycoside; Flavone compound: globulariacitrin; Vinylbenzene analog derivative: Fructus Forsythiae fat glycoside A, C, D, E, Fructus Forsythiae kind glycoside, salidroside; Cyclohexyl alcohol derivatives: (wood comes) wooden glycoside, Fructus Forsythiae Hexalin, different Fructus Forsythiae Hexalin, Fructus Forsythiae cyclohexanol thing, Fructus Forsythiae hexamethylene alcohol ketone, Fructus Forsythiae Hexalin glycoside A, B, C; Triterpenoid compound: white firelight or sunlight fat acid, oleanolic acid, ursolic acid, β-Amyrin acetas, Isobauerenyl Acetate, 20(S)-Da Ma-24-alkene-3 β, 20-glycol-3-acetas etc.

Fructus Forsythiae has certain bactericidal action, can change the permeability of skin simultaneously.

spica Prunellae.pungent, bitter, cold." herbal classic ": " bitter in the mouth is pungent, cold." " not Lu ": " be nontoxic." " book on Chinese herbal medicine is just ": " mildly bitter flavor, micro-pungent."

Return liver, gallbladder meridian." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter liver." " Bencao Jingshu ": " enters sufficient faint the moon, shaoyang channel."

" herbal classic ": " main cold and heat, scrofula, scrofula, head sore, broken disease, loose wart stagnation of QI, swelling of the feet arthralgia chiefly caused by damp pathogen." " Amplification on Materia Medica addendum ": " takes a tonic or nourishing food to build up one's health blood vessels." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " liver-wind of dispelling, network of passing through, controls facial hemiparalysis.Row irritability, opens stagnation of liver-QI, only bones and muscles pain, ophthal malgia, and loose scrofula is stolen, whole body tuberculosis." " the SHENGCAO property of medicine standby want ": " goes expectorant to disappear pus, controls scrofula, clear upper mend under, remove eye mask, pain relieving." " Bencao Congxin ": " controls scrofula, scrofula, goiter, Disorder heavily fortified point, acute mastitis, breast carcinoma." " medicinal herbs among the people of science ": " have diuresis bactericidal action.Decoct can wash wound, controls suppurative outer disease, and washing vagina, controls vaginal orifice and blennometritis." " modern Practical Chinese medicinal ": " is diuretic, effective to gonorrhea, hysteropathy; And can hypertension be controlled, can blood pressure drops be made."

The chemical composition fruit ear of Spica Prunellae is containing ursolic acid, and oleanolic acid, ursolic acid and oleanolic acid are the Saponin of main glycoside unit, daucosterol, and β-Amyrin and its lignoceric acid, 20 produce alkanoic acid, the ester of octocosoic acid and melissic acid.

Herb, containing acidity many grain Polysaccharides from Prunella vulgaris L of tool anti human immune deficiency virus (HIV), also contains oleanolic acid, ursolic acid, oleanolic acid is the Saponin of glycoside unit, globulariacitrin, hyperin, caffeic acid, vitamin C, D, D carotene, tannin, and thing sense and volatile oil, wherein containing levo-camphor, dextrorotation fenchone.

Aerial parts is containing Coumarins compound: umbelliferone, eastern rhinoceros grass element, aesculetin, flavone compound: luteolin, matched moulds orientin also known as isorientin, luteolin-7-O-glycoside, globulariacitrin, golden ratio Fructus Persicae glycoside, Isoquercitrin.

Inflorescence contains the glucoside of delphinidin and cyanidin, primulagenin-3,5-diglucoside, Quercetin, nimbecetin and volatile oil, wherein revolves fenchone containing gum camphor and stone.

Leaf is containing multiple fatty acid: oleic acid, linolenic acid, myristic acid, Palmic acid, and stearic acid and the moon hang acid.

" Amplification on Materia Medica addendum ": take a tonic or nourishing food to build up one's health blood vessels.Spica Prunellae has the effect of invigorating blood circulation.

fructus Jujubae.fructus Jujubae sweet in the mouth is warm in nature, return taste warp, has the function of invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, the mitigation property of medicine; The pharmacology in modern times then finds, Fructus Jujubae contains the abundant nutrition such as protein, fat, saccharide, organic acid, vitamin A, vitamin C, lot of trace calcium and aminoacid.Fructus Jujubae can improve body immunity, and can anticancer: pharmacological research finds, Fructus Jujubae can promote leukocytic generation; reduce serum cholesterol, improve serum albumin, the liver protecting; also containing anticancer in Fructus Jujubae, cancerous cell even can be made to the material of normal cell turnover.

Often the people of edible fresh Fructus Jujubae seldom suffers from cholelithiasis, this is because vitamin C abundant in fresh Fructus Jujubae, makes cholesterol unnecessary in body change bile acid into, little cholesterol, lithogenous probability also just reduces thereupon.

Calcium and ferrum is rich in Fructus Jujubae; they to preventing and treating osteoporosis, postpartum anemia plays an important role; middle-aged and elderly people climacteric often understands osteoporosis; easily there is anemia in the teenager just on growth promoter peak and women; Fructus Jujubae has very good dietary function to them, and its effect normally medicine can not compared.

Fructus Jujubae can also antiallergic, except stench strange taste, mind tranquilizing and the heart calming, brain healthy, appetite strengthening.

Fructus Jujubae can also well can muscle strength reinforcing, allaying tiredness, blood vessel dilating, increase myocardial contraction, improve myocardial nutrition.

Fructus Jujubae contains a large amount of glucides, is mainly glucose, also containing fructose, sucrose, and oligosaccharide, arabinan and the galacturonan etc. that are made up of glucose and fructose; And containing a large amount of multivitamins such as vitamin C, riboflavin, thiamine, carotene, nicotinic acid, there is stronger tonic effect, immune function of human body can be improved, strengthen resistance against diseases.

fructus Crataegi.warm in nature, sweet in the mouth, acid, return spleen, stomach, Liver Channel.There is promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, change effect of turbid blood fat reducing." the southern regions of the Yunnan Province book on Chinese herbal medicine " is recorded: " meat that disappears stagnates, the therapeutic method to keep the adverse QI flowing downwards; Control acid regurgitation, long-pending block." Compendium of Material Medica record: " dissipating fluid-retention is eaten, and disappear meat Ji ， mass in the abdomen, phlegm retention feeling of fullness acid regurgitation, stagnant blood pain with distension." " Records of Tradition Chinese and Western Medicine in Combination " record: " Fructus Crataegi, if help it with sweet medicine, Removing Blood Stasis and do not hinder fresh blood, dissipating depression of QI gas and do not hinder healthy energy, the outstanding peace of its property is also." Tang Materia Medica record: " juice takes main profit, and hair washing and with it skin ulcer are itched." " Bencao Tujing " record: " control dysentery and pain in the lumbar region.”

Fructus Crataegi, mainly containing flavonoid, flavane and polymer class thereof, organic acid, also has triterpenes and steroid etc.

Flavonoid: vitexin, different Herba Viticis Cannabifoliae, orientin, isorientin, nimbecetin, herbaceous stem element, rutin, hyperin, naringenin-5,7-pair-glucoside, Eriodictyol-5,3 '-bis--glucoside, Eriodictyol-7,3 '-bis-glucoside, Taxifolin, Pseudotsuga menziesii (Mirbel) Franco 3-O-b-arabopyranose glycosides, Pseudotsuga menziesii (Mirbel) Franco 3-O-b-xylopyranoside.

Flavanoid: catechin, epicatechin, leucocianidol, front colored indigo A ₂, oligomeric proanthocyanidin B ₂, B ₄, B ₅, dimerization leucocianidol, oligomeric proanthocyanidin C ₁, oligomeric proanthocyanidin D ₁deng, oligomeric proanthocyanidin E ₁.

Triterpenes: triterpenoid compound comprises these 5 kinds, Ursane, cycloartane type, oleanane type, lanoline alkane type and lupinane type.Ursane has ursolic acid, Corosolic acid; Cycloartane type has Huan Atun; Oleanane type has b-balsam, uvaol, oleanolic acid, Crataegolic acid; Lanoline alkane type has butyrospermol, 24-methylene-24-dihydro lanosterol; Lupinane type has betula camphor.

Steroid: b-sitosterol, b-daucosterol, stigmasterol.

Organic acid: comprise phenolic acids and other organic acid, liposoluble ingredient has benzoic acid, gallic acid, protocatechuic acid, chlorogenic acid, β-coumaric acid, caffeic acid, ferulic acid, anisic acid, vanillic acid, syringic acid, gentisic acid etc.; Other organic acid comprises malic acid, citric acid, quinic acid, acetone acid, tartaric acid, Palmic acid, stearic acid, oleic acid, linoleic acid, succinic acid, Fumaric acid, 2-(4-hydroxy benzenes) malic acid, gibberellin, ascorbic acid etc.

Amino acids: the acid of glutamate, Glu, methionine sulfoxide, aspartic acid, agedoite, glutamic acid, sarcosine, citrulline, proline, glycine, alanine, valine.

Ursolic acid, hyperin significantly can reduce the content of cholesterol in serum, triacylglycerol, improve the activity of SOD, prevent the formation of blood vessel scleratheroma.Flavone compound can reduce fatty acid toxic effect on liver cells, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT index is reduced, reaches the effect of relieving the effect of alcohol.The effect that Flavane compound has significant blood vessel dilating, reduces blood pressure.

fructus Corni.sour in the mouth, puckery, slightly warm in nature.Return liver, kidney channel.Liver and kidney tonifying; Convergence is solid de-.Cure mainly and have a dizzy spell; Deafness and tinnitus; Soreness of the waist and knees; Emission and spermatorrhea; Frequent micturition; Incessant sweating due to debility; Woman uterine bleeding; Interior-heat is quenched one's thirst; Warming the liver the kidney invigorating, except a wind cutting, only menorrhagia, controls senile frequent micturition." herbal classic ": pathogen cold and heat under the main heart, warming middle-JIAO, by cold-damp numbness, goes three worms.Lei Gong's Treatise on Preparation and Broiling of Materia Medica: primordial qi strengthening gas, secret essence." not Lu ": the intestines and stomach ailment said due to cold or exposure, cold and heat hernia abdominal mass, wind syndrome of head, pathogenic wind goes, nasal obstruction, and icteric sclera is deaf, pimples, warming middle-JIAO, and the therapeutic method to keep the adverse QI flowing downwards is perspired, reinforcing YIN-essence, benefit essence, settling five organs, logical nine orifices, only normal urination, and improving eyesight is powerful." property of medicine opinion ": control brain osteodynia, only moon water is indefinite, the kidney invigorating gas; Xing Yangdao, adds marrow, treats tinnitus, and except skin ulcer on face, the diaphoresis of main energy, only old man's urine does not save." Japan hanako materia medica ": warm waist knee joint, helps water dirty, except a wind cutting, cuts gas one by one, and broken crux, controls wine Zha." pearl sac ": warming the liver." book on Chinese herbal medicine asks former ": only chronic diarrhea, fever and sweating of having a guilty conscience.

Fructus Evodiae sarcocarp is containing tannin composition: Fructus Corni is tanned hair 1,2,3, and namely Fructus Corni tannin 1 is that different terchebin has another name called Pedicellus et Pericarpium Trapae and belongs to tannin, and namely Fructus Corni tannin 2 is new miterwort element II, and namely Fructus Corni tannin 2 is new miterwort element I; (wood come) wooden tannin A, B, C, G, clove tree tannin, Herba Diclipterae Chinensis tannin D and 2,3-bis--O-galloyl glucose, 1,2,3-tri--O-galloyl glucose, 1,2,6-tri--O-galloyl glucose.Glucoside-containing composition again; Fructus Corni splits glycoside, morroniside, 7-O-methyl morroniside, Semen Strychni glycoside, sweroside.Also containing glucose, fructose, sucrose, ursolic acid, gallic acid, malic acid, tartaric acid and vitamin A etc.Again containing giving as security hair oil, therefrom be separated and obtain 9 monoterpene hydrocarbon, 6 sesquiterpene hydrocarbon, 5 aliphatic hydrocarbons, 7 monoterpene esters and a fatty alcohol, 4 monoterpene aldehyde and ketone, 3 fatty aldehydes and ketone, 4 acid, 18 esters and 15 aromatics, the main component that wherein content is more has: isobutanol, butanols, isoamyl alcohol, cis with trans Camphor tree alcohol oxide of premeditating, bran aldehyde, β-benzene alcohol, methyleugenol, elemicine, different Herba Asari bridal veil, Palmic acid is ester, oleic acid is ester, linoleic acid is ester, benzyl cinnamate, Palmic acid, stearic acid, alpha-terpineol, α-curcumene, anethole, 4-methoxyl group-1, 2-benzodioxole, asaricin (asaricin), aristolone, basic note oxalaldehyde, linolenic acid is ester, pulegone, safrole etc.Containing linoleic acid in core, oleic acid, Palmic acid, stearic acid, linolenic acid, 21 kinds of elements such as the fatty acids such as lauric acid and ferrum, aluminum, copper, zinc, boron, phosphorus.All containing threonine in sarcocarp and core, valine, leucine, isoleucine, phenylalanine, histidine, lysine, serine, glutamic acid, glycine, alanine, tyrosine, arginine, aspartic acid etc. 14 seed amino acid, also separately has methionine in core, proline, cystine.

prescription B:

radix Scutellariae.nature and flavor: bitter, cold." herbal classic ": bitter in the mouth, flat." not Lu ": Great Cold, nontoxic." property of medicine opinion ": bitter but sweet flavor.

Gui Jing: enter the heart, lung, gallbladder, large intestine channel." product remittance essence is wanted ": row hands is lunar, Yangming Channel." detailed outline ": few yin, yang of starting with is bright, lunar, the few positive the six channels of brothers." Thunder God concocts property of medicine solution ": enter lung, large intestine, bladder, gallbladder four warp.

" herbal classic ": main all hot jaundice, intestinal Bleach, lets out profit, relieves oedema or abdominal distension through diuresis or purgation, and hematochezia closes, (controlling) malignant boil, and cellulitis is lost, acute scleritis." not Lu ": treat expectorant heat, pathogenic heat in the stomach, little angina abdominis, rapid digestion of food, sharp small intestinal, woman's blood closes, drenches dew hematochezia, abdominal pain in children.TAO Hong-Jing: control renal mass, burning pain under umbilicus." property of medicine opinion ": can control pyretic toxicity, hectic fever due to YIN-deficiency, alternate attack of chill and fever, the intestines and stomach is unfavorable, broken heap soil or fertilizer over and around the roots gas, controls five types of stranguria, makes us a surname freely, goes to joint unhappy, yearningly antipyretic, and control hot Fu Zhong Xu pain, trusted subordinate's heavily fortified point is swollen." Japan hanako materia medica ": the therapeutic method to keep the adverse QI flowing downwards, the capable hot disease in main sky, furuncle, evacuation of pus.Control acute mastitis, carbuncle on the back." pearl sac ": except sun is had a surplus, the cool heart reduces phlegm and internal heat, logical rejection syndrome due to the lower cold excluding the heat upward.Li Gao: control heating bitter taste." the southern regions of the Yunnan Province book on Chinese herbal medicine ": up purte the white, descendingly rushes down bladder fire, (controlling) man five types of stranguria, woman's sudden onset of metrorrhagia, regulating menstruation heat clearing away, and tire has burning hot uneasiness, clear fetal heat in pregnancy, except the six channels excess-fire excess-heat." detailed outline ": control the damp and hot headache of wind heat, renal mass burning pain, cough caused by pathogenic fire, consumptive lung disease larynx raw meat, allly loses blood." book on Chinese herbal medicine is just ": the fire of the clear part of the body cavity above the diaphragm housing the heart and lungs of withered person, expectorant promoting the circulation of QI, relieving asthma and cough, only loses blood, and moves back alternate attacks of chills and fever, and wind heat is damp and hot, headache, separates pestilence, moistening and cleaning throat, treats consumptive lung disease lung abscess, acute mastitis carbuncle on the back, the heat of flesh table of especially dispelling, therefore controls macule, scrofula, skin infection, acute conjunctivitis; The heat of the cool part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels of reality person, can remove bloody dysentery, heat stores bladder, the puckery pain of five types of stranguria, and large intestine closes knot, has blood in stool, leaks blood." medicinal herbs among the people of science ": washout wound, has antisepsis.

The chemical composition of Radix Scutellariae: scutellariae,radix is containing flavone compound: baicalin, neobaicalein, i.e. skullcapflavone II, baicalin, wogonin, wogonoside, oroxylin A, 7-methoxyl group baicalin, skullcapflavone I, dihydro oroxylin A, chrysin, 2, 5, 8-trihydroxy-7-methoxy flavone, 2, 5, 8-trihydroxy-6, 7-dimethoxy flavone, 4, 5, 7-trihydroxy-6-methoxy flavanone, 2, 3, 5, 6, 7-penta hydroxy group flavanone, wogonin-5-β-D-Glucose glycoside, 2-(3-hydroxyl-4-methoxyphenyl)-ethyl-1-O-α-L-rhamanopyranosyl (1 → 3)-β-D(4-Resina Ferulae acyl group)-glucose, chrysin-6-C-α-L-arabinose glycoside, chrysin-6-C-α-L-arabinose glycoside-8-C-β-D-Glucose glycoside, (2S)-2, 5, 6, 7-tetrahydroxy flavanone, 5, 7, 2, 6-kaempferol, 5, 8-dihydroxy-6, 7-dimethoxy flavone, 5, 7, 4-trihydroxy-8-methoxy flavone, oroxylin A-7-O-glucuronide, 5, 7, 2-trihydroxy methoxy flavone, 5, 2-dihydroxy-6, 7, 8-trimethoxy flavone, 5-gate of a lane base-7, 8-dimethoxy flavone, Norwogonin, dihydro baicalin, 5, 7, 2-trihydroxyflavone, 5, 7, 2-trihydroxy-8, 6-dimethoxy flavone, 5, 7, 2, 5-tetrahydroxy-8, 6-dimethoxy flavone and viscidulin Ⅲ, 5, 2, 5-trihydroxy trimethoxy flavone, baicalin-7-O-β-D-glucopyanoside, 5, 7, 2-trihydroxy-8-methoxy flavone, 5, 7, 2, 3-kaempferol, 5, 7, 2, the great base flavone of 3-tetra-, 3, 5, 7, 2, 5, 6-pentahydroxyflavone, i.e. viscidulin Ⅰ, (2S)-7, 2, 6-trihydroxy-5-methoxy flavanone, 2, 6, 2, 4-tetrahydroxy-6-methoxyl group chalcone, 5, 7, 2, 5-kaempferol, left-handed eriodictyol, Herba Scutellariae Barbatae kind element and viscidulin Ⅲ-2-O-β-D-glucopyanoside etc.In addition also containing cupreol), campesterol and stigmasterol.

herba Violae Hortensis.nature and flavor bitter in the mouth, cold in nature.Gui Jing enters lung meridian.Herba Violae Hortensis is 2 years or herbaceos perennial of Violales, Violaceae, Viola.Chinese crude drug Herba Violae Hortensis also can sterilize, comedo, acne, allergic problem on treatment skin.

The chemical composition of Herba Violae Hortensis: stem, leaf are containing violanthin.

Flower is containing globulariacitrin, and tocopherol, lycopene, phytofluene, bata-carotene, phylloxanthin, violaxanthin, antheraxanthin, 9,9-cis-antheraxanthin, corpus luteum furan element, Herba Violae Hortensis flavonoid glycoside, leads violaxanthin.

Herb contains Quercetin, luteolin, luteolin-7-glycoside, protocatechuic acid, trans-caffeic acid, cis and trans P-coumaric acid), P-hydroxybenzoic acid, para hydroxybenzene is sour, salicylic acid, vanillic acid, the syringic acid of gentisic acid and trace, ferulic acid.Also containing saccharide: wherein main water soluble polysaccharide system by D-Fructus Vitis viniferae, D-galactose, L-arabinose; A small amount of monosaccharide has D-galactobionic acid Galactonic acid, D-xylose and L-rhamnose, pectin, and part is containing D-galacturonic acid, D-Glucose and D-galactose.Another containing 4 terpenes and 4 triterpenes and steroids etc.

chinese corktree.for rutaceae wampee.Bitter in the mouth, cold in nature.Return kidney, urinary bladder channel.

rhizoma Solani tuber osi.property is put down, sweet in the mouth.Belong to Solanaceae herbaceos perennial.Compendium of Material Medica: " the rare pox of function, children's's prepared food, pox of having a bowel movement poison."; " Hunan medicine will ": " invigorating the spleen and replenishing QI, strengthening the spleen and stomach, antiinflammatory." ingredient in fresh potato: starch 9 ~ 20%, protein 1.5 ~ 2.3%, fat 0.1 ~ 1.1%, crude fibre 0.6 ~ 0.8%.Nutritional labeling contained in 100g Rhizoma Solani tuber osi: energy 318 kilojoule, calcium 5 ~ 8mg, phosphorus 15 ~ 40mg, ferrum 0.4mg ~ 0.8mg, potassium 200 ~ 340mg, iodine 0.8 ~ 1.2, carotene 12 ~ 30mg, thiamine 0.03 ~ 0.08mg, riboflavin 0.01 ~ 0.04mg, nicotinic acid 0.4 ~ 1.1mg.Rhizoma Solani tuber osi has antidotal effect.It contains the vitamin B group such as abundant vitamin B1, B2, B6 and pantothenic acid and a large amount of good fiber quality element, also containing nutrients such as trace element, aminoacid, protein, fat and high-quality starch.The antimicrobial component contained in Rhizoma Solani tuber osi helps preventing gastric ulcer, and it not only has antibacterial effect effect, can not cause Drug resistance simultaneously.

cedrus deoclar (Roxb.) G. Don quintessence oil.cedrus deoclar (Roxb.) G. Don quintessence oil is from the flower of Cedrus deoclar (Roxb.) G. Don, leaf, stem, root or fruit, refines the volatile flavor of extraction.Cedrus deoclar (Roxb.) G. Don quintessence oil has significant antiinflammatory, antibacterial, convergence, diuresis, softness, reduce phlegm, the effect of antifungal, benefit body, convergence, antibacterial characteristic are conducive to oiliness skin quality most, also can improve pimples and acne-prone skin.

semen Cassiae.sweet in the mouth, hardship, cold in nature, micro-salty.Return liver, large intestine channel.There is liver heat removing and eyesight improving, the effect of loosening bowel to relieve constipation.Compendium of Material Medica: " except liver and gall wind heat, excessive skin tunica albuginea, optic atrohic blindness." " China book on Chinese herbal medicine " to state its application comparatively extensive, carry and say: " liver heat removing kidney tonifying, improving eyesight, diuretic relieving constipation.Cure mainly conjunctival congestion and swelling pain, photophobia tear be many, optic atrohic blindness, nyctalopia, headache and dizzy, poor vision, cirrhotic ascites, dysuria, habitual constipation.External treatment toxic swelling, tinea disease." " herbal classic ": " control optic atrohic blindness, the red tunica albuginea of the excessive skin of order, swelling ophthalmalgia, lacrimation, clothes benefit is with nothing left for a long time." " Bencao Jingshu ": " Semen Cassiae, its salty in the mouth is put down, and " not record " is beneficial nontoxic with sweet being slightly cold of hardship.Salty aqueous vapor, rusticly sweet, hardship can expel the heat-evil, and flatly closes gastric qi, coldly can expel the heat-evil by tonifying YIN, and the positive medicine of liver meridian man also.Also gallbladder kidney is entered.Liver opening at eye, gb 1 God Light belongs to kidney, therefore main optic atrohic blindness order is excessive, the red tunica albuginea of skin, swelling ophthalmalgia lacrimation." not Lu " holds concurrently and treats blue-purple lips." herbal classic " takes beneficial with nothing left person for a long time, tonifying YIN expels the heat-evil, caused by the gas of large invigorating the liver and kidney also." " book on Chinese herbal medicine is looked for the truth ": " Semen Cassiae, except wind heat radiation.Ordinary person's order tear is not received, and ophthalmalgia is more than, excessive in many genus wind heat, not up with hyperamization, controls when being expulsion; Can expel the heat-evil by this hardship, salty can softening the hard mass, sweetly can enrich blood, the thin air supporting of power, can rise loose ailment said due to cold or exposure again, therefore receives tear pain relieving key medicine for controlling order.And can rest the head on to control wind syndrome of head, but these clothes too, search wind to very, anti-evil of catching the wind, therefore must close with Fructus Tribuli, Flos Chrysanthemi, Fructus Lycii, the Radix Rehmanniae, Fructus Ligustri Lucidi reality, Fructus Sophorae, Flos Eriocauli mutually for subsidizing, then merit more wins.Namely the Semen Cassiae of meaning is this meaning." " book on Chinese herbal medicine justice ": " Semen Cassiae improving eyesight, being grow liver and kidney tonifying, with tranquillizing and subduing nourishing YIN for justice, is the routine treatment of reinforcing, non-as the pungent loose wind of temperature, and cold and cool what fall heat is only that secondary disease legislator is comparable, has every advantage and not a single disadvantage the most.”

The chemical composition of Semen Cassiae is for containing emodin, chrysophanol, physcione, obtusin, obtusin and glycoside thereof.

Semen Cassiae, except containing except saccharide, protein, fat, also containing steroidal compounds, chrysophanol, emodin etc., also has the trace elements iron, zinc, manganese, copper, nickel, cobalt, molybdenum etc. of needed by human.Contained emodin, chrysophanic acid have human body relieving asthma, function of gallbladder promoting, protect the liver, antihypertensive effect, and have necessarily antibacterial, antiinflammation.Wherein emodin monoglucoside, emodin anthrone, physcione, has and reduces serum cholesterol and cardiotonic.Semen Cassiae element has a-hydroxyl, can synthesize complex, absorb have a significant impact metallic element with metal element.

flos Lonicerae.sweet, cold." not Lu ": sweet, temperature, nontoxic." property of medicine opinion ": acrid in the mouth.Supplement to the Herbal: Slight Cold." book on Chinese herbal medicine is new again ": sweet-bitter flavor, cold nature.Enter the heart, lung meridian." key medicine divides agent ": enter lung meridian." book on Chinese herbal medicine is new again ": enter the heart, lung two warp." not Lu ": main cold and heat body swells.TAO Hong-Jing: liquor is with wine brewing, and tonify deficiency treats wind." property of medicine opinion ": main distention and fullness in the abdomen, can rustic lower Bleach.Supplement to the Herbal: main toxic-heat and blood stasis water dysentery.《 Lv Cliff rock book on Chinese herbal medicine ": control bones and muscles pain." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, expectorant, heat of dispeling the wind, clearing throat burning pain." detailed outline ": control all rheumatism gas and all toxic swellings, carbuncle scabies, Fructus Myricae rubrae malignant boil, heat radiation removing toxic substances." book on Chinese herbal medicine is new again ": control hyperactivity of fire of having a guilty conscience, QI invigorating alleviating distention in middle-JIAO, cough, carbuncle flaccidity." Nanjing medicinal herbs among the people ": stem and leaf and spending effective in cure during inflammatory eye." Guizhou side's medicine among the people collection ": leaf: knife injury is controlled in external application.

The composition of Flos Lonicerae is chlorogenic acid, isochlorogenic acid.Aerial parts contains Semen Strychni glycoside, disconnected Semen Strychni glycoside dimethylacetal, disconnected Semen Strychni glycoside hemiacetal lactone, the disconnected Semen Strychni glycoside of table, hemiacetal lactone, and helexin, oleanolic acid, goes back the trace element such as iron content, barium, manganese, zinc, titanium, strontium, copper.

Leaf is containing luteolin, Radix Ophiopogonis is plain, 3-methoxyl group-5,7,4-trihydroxyflavone, luteolin-7-Fructus rhamni (Rhamnus davurica Pall.) glycoside and lonicerin, the two galactoside of luteolin-7-O-, Radix Ophiopogonis element-6-Fructus rhamni (Rhamnus davurica Pall.) glycoside, isochlorogenic acid and caffeic acid, vanillic acid and venoterpine, wild rice gland Radix Ophiopogonis aerial parts is containing left-handed-4-hydroxyl-2,6-bis--(4-hydroxy-3-methoxy) phenyl-3,7-dioxy-bicyclo (3,3,0) octane, n-10-nonacosanol, scopoletin, syringic acid, cupreol and cupreol glycoside.Sprout is containing disconnected oxidation Semen Strychni glycoside.

Wherein contained luteolin has antibacterial, antiinflammation.

flos Caryophylli.it is warm in nature, acrid in the mouth." Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." " detailed outline ": " is pungent, heat."。Return stomach, spleen, kidney channel.Materia Medica of Decoction: " start with lunar, bright, the shaoyin channel of foot sun."

" property of medicine opinion ": " control cold air stomachache." " Haiyao Bencao, Oversea Materia Medica ": " main air infantile malnutrition is hidden, and bone groove labor is smelly.Control gas, black moustache is sent out, parasite killing, treats five hemorrhoid, wards off evil and uncharms.Control milk headdress flower, only multicolored fulminant dysentery, healthy energy, only cardiac and abdominal pain." " Japan hanako materia medica ": " controls implication, regurgitation, treats kidney qi, sensation of gas rushing, pain over the perineum, tonifying YANG, and warm waist knee joint, kill alcoholism, disappear mass beside the umbilicus, except consumptive disease with cold nature." " Kaibao Bencao ": " warming the spleen stomach, only cholera.(controlling) stops up swollen, and pathogenic wind toxic is all swollen, and tooth infantile malnutrition is hidden." " book on Chinese herbal medicine cover bamboo fish trap ": " only gas make a mistake, QI rising in reverse order." " detailed outline ": " controls the empty sound of vomiting, and vomiting and diarrhea in children, variola insufficiency of stomach is greyish white not to be sent out." " book on Chinese herbal medicine just ": " fast gas of warming middle-JIAO.Control part of the body cavity above the diaphragm housing the heart and lungs singultus, except cold syndrome of the stomach dysentery, seven emotions five are strongly fragrant." " book on Chinese herbal medicine converges ": " treats the thoracic obstruction, pain over the perineum, warm vaginal orifice." " medical center bun want ": " tonifying liver, the profit gate of vitality, warming the stomach, go invasion by pathogenic cold, eliminating the pathogens from the lung, loose rheumatism." " book on Chinese herbal medicine is new again ": " opens nine orifices, Shu Yuqi, removes wind, row water." " pharmacognosy ": " controls chronic indigestion, gastrointestinal inflation and uterus colic."

Flos Caryophylli claims lilac, and this platymiscium is machaka or dungarunga.There is the effect of warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.It is good stomach warming medicine simply still, to the stomachache caused by cold-evil, vomiting, singultus, suffers from abdominal pain, has loose bowels and the cold dysmenorrhea of women etc., all have good curative effect, it also can alleviate abdominal part flatulence, strengthen digestion power, alleviate nausea and vomiting, especially anemia of pregnant woman suffers from morning sickness symptom.Flos Caryophylli contains Oleum Caryophylli, has inhibitory action, also can do external, have good curative effect to tinea corporis and tinea pedis for pathogenic fungus and staphylococcus, dysentery and escherichia coli etc.

folium piperis betlis.pungent, temperature.Tang Materia Medica: " acrid in the mouth." " herbal classic is met former ": " is pungent, temperature, nontoxic." dispeiling pathogenic wind and removing dampness, killing parasites for relieving itching.Control cough due to wind and cold, stomachache, pathogenic wind-toxic beriberi, edema during pregnancy, mange, eczema, tinea pedis, scald." detailed outline ", " separates communicable subtropical diseases, removes evil gas in the heart, warming the spleen dampness." " herbal classic is met former ": " therapeutic method to keep the adverse QI flowing downwards warming middle-JIAO, broken expectorant, eliminating stagnation gas." " book on Chinese herbal medicine asks former ": " washes pathogenic wind toxic swelling of the feet, mange." " age south gather medicinal herbs record ": " controls cough due to wind and cold, retention of placenta, horse mouth furuncle and burn." " Luchuan book on Chinese herbal medicine ": " anthelmintic, detumescence, antipruritic, removing the necrotic tissue and promoting granulation.Control infantile malnutrition furuncle, ulcer, carious pain." " south of the Five Ridges herbal ": " applies sore, smoked hemorrhoid, reason traumatic injury." " Guangdong Chinese herbal medicine ": " controls edema during pregnancy, furuncle, skin eczema, tinea pedis, cold syndrome of the stomach pain."

Chemical composition, leaf, containing volatile oil, includes chavicol 7.2 ~ 16.7%, chavicol 2.7 ~ 6.2%, allylpyrocatechol 0 ~ 9.6%, carvacrol 2.2 ~ 5.6%, eugenol 26.8 ~ 42.5%, cymol 1.2 ~ 2.5%, 1, 8-Cineole 2.4 ~ 4.8%, methyleugenol 4.2 ~ 15.8%, caryophyllene 3.0 ~ 9.8%, Cadinene 2.4 ~ 8.8%, and uncertain sesquiterpene 4.5 ~ 6,8% etc.Ye Zhongshang is containing multiple free amino acid, ascorbic acid, malic acid, oxalic acid, glucose, fructose, maltose, glucuronic acid etc.Every hectogram iron content 25 milligrams.There is certain antibacterial action.

prescription C:

radix Asparagi.sweetness and bitterness, cold." herbal classic ": " bitter in the mouth is flat."; " not Lu ": " sweet, Great Cold, nontoxic."; " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold in nature, sweet and slightly bitter taste."。Enter lung, kidney channel.Materia Medica of Decoction: " lunar, meridian of Foot-SHAO YIN of starting with."; " book on Chinese herbal medicine is through separating ": " enter lung meridian, heart channel of Hand-Shaoyin." " herbal classic ": " main all storm wind wet inclined numbness, and bone strengthening marrow, kills three worms." " not Lu ": " Baoding lung qi, cold removing heat, supports skin, physical strength profiting, diuresis, cold and can mend." " property of medicine opinion ": " main lung qi cough with dyspnea, pants short anxious, heat extraction, and logical kidney qi is treated the raw carbuncle vomiting pus of consumptive lung disease, controlled scabies humida, only quench one's thirst, apoplexy of reducing phlegm and internal heat.Should take for a long time." " prescriptions worth thousand gold ": " is controlled asthenia and is hindered absolutely, the damage that declines old age weakness and emaciation, hemiplegia not with, rheumatism is meciless, cold numbness, and trusted subordinate gathers, malignant boil, and carbuncle swells leprosy, also controls impotence, deafness, order are dark." " Japan hanako materia medica ": " relieving palpitation, moistening five ZANG-organs, beneficial skin, improving healthy complexion, mends five kinds of strain and seven kinds of impairment, controls lung qi and cough, expectorant, migratory arthralgia pyretic toxicity, urticaria, unhappy haematemesis." Wang Haogu: " main cardiopathia dry sensation in the pharynx, pained, wish drink yearningly, flaccidity Jue drowsiness, foot burning pain." " book on Chinese herbal medicine covers bamboo fish trap ": " can remove pyretic stranguria, and the excessive absurd row of hemostasis, profit excrement is dry constipated." " detailed outline ": " moisturizes YIN nourishing, clearing and descending lung-fire." " Zhiwu Mingshi Tukao ": " pulls out furunculosis." " not Lu ": " Baoding lung qi, cold removing heat, supports skin, physical strength profiting, diuresis, cold and can mend.”

The chemical composition tuber of Radix Asparagi is containing steroid saponin: Radix Asparagi furan sterol oligosaccharide glycoside Asp-IV, Asp-V, Asp-VI, Asp-VII, methyl Protodioscin, pseudo-Protodioscin, 3-O(α-L-rhamnopyranosyl (1 → 4)-β-D-glucopyranosyl)-26-O-(β-D-glucopyranosyl)-(25R)-5,20-furan steroid diene-3 β, 26 glycol.Closely get 6 steroid saponins from fresh rhizome again, its glycoside unit is Yamogenin, diosgenin, chinaroot greenbrier sapogenin, smilagenin, and sugared portion, not containing xylose, only contains glucose and rhamnose.Again containing 7 oligosaccharide I-VII, be respectively three polysaccharide containing glucose and fructose, four polysaccharide, five polysaccharide, hexa polyose, eight polysaccharide, nine polysaccharide and ten polysaccharide.Also containing glucose, fructose, sucrose, 5-methoxy alditol, cupreol and citrulline, agedoite, serine, threonine, proline, glycine, alanine, valine, methionine, leucine, isoleucine, phenylalanine, cruel propylhomoserin, aspartic acid, glutamic acid, arginine, histidine, the several amino acids such as lysine.Closely from tuber tumor suppression effective site, isolate 4 kinds of polysaccharide: Radix Asparagi Polysaccharide A, B, C, D.

Radix Asparagi door has intestine moistening stomach, supports the advantage of skin.

olive oil.olive oil is formed by the fresh direct cold pressing of Fructus oleae europaeae fruit.Olive oil is rich in the Squalene splendid with skin affinity and essential fatty acid, absorbs rapidly, effectively keeps skin elasticity with moist; Monounsaturated fatty acid contained abundant in olive oil and vitamin E, K, A, D etc. and phenols antioxidant, facial wrinkles can be eliminated, prevent skin aging, there is the effect such as skin or hair care and control hand and foot from chapping, be the cosmetics and skincare product that can " eat ", smear skin energy ultraviolet rays resistance with olive oil in addition and prevent skin carcinoma.

In the numerous composition of olive oil, carotene and chlorophyll give olive oil yellow green, and chlorophyll plays metabolism, Promote cell's growth, accelerating wound healing.Also contribute to the appearance of beautify people, reduce the generation of wrinkle.Experiment shows, the antioxidant that olive oil contains can eliminate interior free yl, recovers the health status of viscera organ, can prevent brain aging, and can life lengthening.

rosemary ethereal oil.rosemary ethereal oil is a kind of colourless to faint yellow volatile liquid.Rosemary ethereal oil can potently be restrained, and consolidation is lost weight, wrinkle resistant, regulates the effect of cortex, nurses one's health greasy unclean skin, blood circulation promoting.

Herba Rosmarini Officinalis composition is australene C ₁₀h ₁₆, Camphora C ₁₀h ₁₆o, pinanone C ₁₀h ₁₄o, borneol acetate C ₁₂h ₂₀o2, lauro lene C ₁₀h ₁₆, nopinene C ₁₀h ₁₆, linalool C ₁₀h ₁₈o, myrcene C ₁₀h ₁₆, Borneolum Syntheticum C ₁₀h ₁₈o, limonene C ₁₀h ₁₆, 18-eucalyptol C ₁₀h ₁₈o, β-phellandrene C ₁₀h ₁₆, γ-terpinene C ₁₀h ₁₆, α-phellandrene C ₁₀h ₁₆, p-cymene C ₁₀h ₁₄, cis-β-ocimene C ₁₀h ₁₆, terpinene-4-alcohol C ₁₀h ₁₈o, alpha-terpineol C ₁₀h ₁₈o, 10-Pinen-3-ol C ₁₀h ₁₆o, α-terpinene C ₁₀h ₁₆, geraniol C ₁₀h ₁₈o and LINL-OX.

herba Damnacanthi.nature and flavor: bitter sweet are flat." Bencao Tujing ": " sweet in the mouth." " Zhejiang traditional herbal medicine ": " sweet in the mouth, property is put down, nontoxic." " Jiangxi traditional herbal medicine proved recipe ": " property is put down, and bitter but sweet flavor is nontoxic."

" Bencao Tujing ": " manage all wind diseases that swell and ache." " Zhiwu Mingshi Tukao ": " fills blood." " Zhejiang traditional herbal medicine ": " root and flower: invigorate blood circulation, sharp joint.Control pathogenic wind." " will planted by Hangzhou medicine ": " dispelling the wind and dampness pathogens pain." " register planted by Guangxi medicine ": " root: cough-relieving, gas of enriching blood.Control pneumonopathy, internal injury." Guangzhou army " conventional Chinese herbal medicine handbook ": " inducing diuresis to remove edema, promoting blood circulation to remove blood stasis.Treating acute and chronic hepatitis, spleen enlargement."

The root of large shape Herba Damnacanthi is containing multiple anthraquinone component damnacanthal, damnacanthol, damnidin, juzunal, demethyl damnacanthal, Norjuzunal, benzylxanthopurpurin, alizarin-1-methyl ether, 5-hydroxyl alizarin-1-methyl ether.

serissa foetida.light, micro-pungent, cool.

Chemical composition: main containing glycoside and tannin.Leaf, containing volatile oil (1%), also contains plant sterol, a small amount of alkaloid, sugar and fatty acid (being saponification resultant).

fructus Tribuli.pungent, bitter, tepor; Slightly poisonous.Return Liver Channel.

Chemical composition: containing steroidal saponin, its sapogenin is diosgenin, ruscogenin, sea can soap former times unit, Gitogenin etc.Another containing Fructus Tribuli glycosides, astragalin, kaempferol-3-rutinoside, Harmane, harmine, water soluble polysaccharide etc.

herba Centellae.bitter, acrid, cold." herbal classic ": " bitter in the mouth, cold." " not Lu ": " be nontoxic." " Japan hanako materia medica ": " bitter in the mouth is pungent." " book on Chinese herbal medicine asks former ": " is sweet light pungent, cold."

" Quanzhou book on Chinese herbal medicine ": " enter liver,spleen,kidney three warp." " east, Fujian book on Chinese herbal medicine ": " enters the heart, lung, spleen, stomach, the large intestine Five Classics." return liver,spleen,kidney warp.

Clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating.Control eruptive disease stomachache, diarrhea due to summer-heat, dysentery, jaundice due to damp-heat, sand Stranguria, stranguria with blood, tells, is defeated in battle, hemoptysis, conjunctival congestion, and larynx swells, rubella, scabies, furuncle carbuncle poison, traumatic injury." herbal classic ": " main large heat, malignant boil, carbuncle, contamination, red Blaze, skin is red, fever of the body." " property of medicine opinion ": " controls scrofula fistula of tuberculous lymphadenitis, the dealing of cold and heat time." Tang Materia Medica: " is smash and is applied the swollen erysipelas of heat." " Japan hanako materia medica ": " moves subsides with salt, detumescence poison also rubella scabies." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controls meridian hectic fever, and dizzy, be afraid of cold, limbs are aching and tired, poor appetite, the virgin infantile malnutrition of male woman, deficient fever do not move back person with it, diuresis, buffalo meat is for drawing." " detailed outline ": " grinds the sudden and violent acute conjunctivitis of juice point." " book on Chinese herbal medicine asks former ": ", except pyretic toxicity, controls nebulousurine, leaching chancre, reason small intestine-QI." " conventional glossary of Herbs and Drugs among the people ": " diuretic and spleen.Harness the river and rush down and dysentery with red and white feces." " Luchuan book on Chinese herbal medicine ": " removing toxic substances, pathogenic fire purging, diuresis.Control febrile disease, headache, fever of the body, thirsty, yellowish or reddish urine." " Traditional Chinese Medicine in Sichuan will ": " expelling wind and cold.Control cough due to lung-heat, disappear goiter, is coated with carbuncle pyogenic infections from tumour or sore, helps digestion long-pending glutted." " east, Fujian book on Chinese herbal medicine ": " controls summer-heat eruptive disease, abdominal pain and distension." " Guangdong Chinese medicine " II: " clearing away summer-heat heat, remuval of damp and hot.Treating the liver enlargement, pleuritis, two single throat moth, prevents and treats measles, and separates gelsemism."

Containing the Triterpenoid of multiple α-balsam alcohol type, wherein there are Asiaticoside, thankuniside, isothankuniside, madecassoside, brahmoside, broken hot rice glycoside and Brahmic acid etc., and madasiatic acid.In addition, still containing meso inositol, centellose, wax, Radix Dauci Sativae hydro carbons, chlorophyll, and nimbecetin, Quercetin and glucose, rhamnose flavonoid glycoside.Herb is mainly containing triterpenic acid and triterpenoid saponin.Triterpene has asiatic acid, Madecassic acid, different Madecassic acid and the acid of birch skin etc.Triterpenoid saponin has Asiaticoside, madecassoside, Herba sambuci chinensis three glucoside and Herba sambuci chinensis four glucoside, and meaning is containing the withered glycoside of ginseng and the withered glycoside of different ginseng again.Another containing kaempferol and Quercetin and glycoside, accumulated snow potash, meso inositol, Herba Centellae oligosaccharide, sitosterol, vitamin C, carotene, green volatile oil and resinoid.

Herba Centellae is cold in nature, has heat-clearing and toxic substances removing, inducing diuresis and reducing edema, nourishing, antiinflammatory, quelling effect.Deep skin cell can be stimulated to substitute.Herba Centellae can be compacted epidermis and corium coupling part, and skin can be made to limber up, and contributes to solving cutis laxa phenomenon, makes skin smooth flexible; Promote that collagen protein is formed in skin corium, makes fibrin regenerate, reconnects, skin is reached compact smooth effect.Herba Centellae has the regeneration of promotion skin collagen, strengthens cell based bottom cell viability, keeps elasticity of skin and consolidation; Antioxidation, suppresses free radical activity, regulates skin immunity; Desalination melanin pigmentation, upgrades skin cell regeneration; Increase skin water conservation degree, activation upgrades skin cell; Antiallergic protective action, protection skin is from external injury.Also can help impaired organization healing and consolidation skin.Can to promote between epidermis with corium close is connected, the increase of adipose cell can be suppressed again, prevent hydroderma, occur fat.Containing the Triterpenoid containing multiple α-balsam alcohol type in Herba Centellae, wherein there are Asiaticoside, thankuniside, isothankuniside, madecassoside, brahmoside, broken hot rice glycoside and Brahmic acid etc., and madasiatic acid.In addition, still containing meso inositol, centellose, wax, Radix Dauci Sativae hydro carbons, chlorophyll, and nimbecetin, Quercetin and glucose, rhamnose flavonoid glycoside.Herb is mainly containing triterpenic acid and triterpenoid saponin.Triterpene has asiatic acid, Madecassic acid, different Madecassic acid and the acid of birch skin etc.Triterpenoid saponin has Asiaticoside, madecassoside, Herba sambuci chinensis three glucoside and Herba sambuci chinensis four glucoside, and meaning is containing the withered glycoside of ginseng and the withered glycoside of different ginseng again.Another containing kaempferol and Quercetin and glycoside, accumulated snow potash), meso inositol, Herba Centellae oligosaccharide, sitosterol, vitamin C, carotene, green volatile oil and resinoid.

prescription D:

herba thymi vulgaris.acrid in the mouth, warm in nature.

Main component is the multiple compounds such as thymol, carvacrol, linalool and cymol.There are antitussive, antiinflammatory, the effect such as anticorrosion.Herba thymi vulgaris is containing flavone component and volatile oil such as baicalin, glucoside, luteolin-7-glucoside, apigenins, and excess has comparatively strong and stimulating.

camellia sinensis.hardship, flat.

Chemical composition: chemical composition be to the Meng ethylene, dipentene, limonene, cineol, Oleum sesami brain, anisoxide.

fructus Citri Limoniae.really: sour, sweet, flat.Root: pungent, bitter, temperature.

Containing flavonoid glycoside such as hesperidin, naringin, eriocitrin, eriodictyol glucoside, 6-methoxyl group citrin-3-β-D-Glucose glycoside, different 6-methoxyl group citrin-3-β-D-Glucose glycoside and citrin-3-β-D-Glucose glycosides in lemon fruit; The organic acid such as citric acid, malic acid and quininic acid; And d-only power element II.

Containing multiple flavonoid, organic acid, Coumarins, sterol, volatilization wet goods in lemon peel.In flavonoid, except hesperidin, eriocitrin, also have neohesperidin, daflon, 6,8-two (carbon bond-glucosyl group)-apigenin, Quercetin-3,5-diglucoside, aureusidin-6-scillabiose, aureusidin-6-glycoside, aureusidin, isorhamnetin-3-arabinose glycoside, citrin-3-arabinose glycoside and 6-methoxyl group citrin-3-arabinose glycosides etc.In organic acid, except quininic acid, also containing caffeic acid, p-coumaric acid, ferulic acid and sinapic acid.Umbelliferone and scopoletin is had in Coumarins.Sterol has cupreol.Volatile oil content is about 0.3%, and wherein about 90% is (R)-4-isopropenyl-1-methyl-1-cyclohexene, and about 3% is citral, also has a small amount of Geraniol acetas and linalyl-acetate.

In the peel of Canton lemon, containing hesperidin, cupreol and clionasterol.

General also containing compositions such as vitamin B1, B2, C, Yan acid, saccharide, calcium, phosphorus, ferrum in citron fruit.

radix Kadsurae longipedunculatae.nature and flavor: pungent, temperature.Spleen; Stomach; Liver Channel." detailed outline is picked up any lost article from the road ": the pungent perfume (or spice) of abnormal smells from the patient." conventional Chinese herbal medicine handbook ": micro-sweetness and bitterness, tepor.

Circulation of qi promoting, invigorates blood circulation, pain relieving.Control stagnation of QI abdominal distention and pain, stomachache, bones and muscles pain, menstrual pain, traumatic injury, innominate toxic swelling.Wang Lianshi " book of gathering medicinal herbs ": " enter cream use, promoting the circulation of blood is fallen apart gas." " detailed outline is picked up any lost article from the road ": " controls pathogenic wind pain, overstrain, injury from falling down, gastric qi pain, food stagnation, the diseases such as acute filthy disease, all wine decoctions." " Jiangxi traditional herbal medicine proved recipe ": " promoting the circulation of blood, regulates the flow of vital energy, relieving distension, pain relieving, ascarifuge." Guangzhou army " conventional Chinese herbal medicine handbook ": " promoting blood circulation by removing wind, eliminating stasis to stop pain.Control chronic gastritis, gastric and duodenal ulcers, acute gastroenteritis, bones and muscles pain due to rheumatism, the traumatic injury stasis of blood is long-pending to swell and ache." " Zhejiang natural resources of Chinese medicinal materials register ": " controls heart peratodynia, menstrual pain."

Containing the anwulignan of dextrorotation in root, five lactones, the acid of long south, meso dihydroguaiaretic acid, cupreol, schizandrin, schisandra chinensis alcohol, Ge meter Xin, Radix Angelicae Sinensis acyl Ge meter Xin, schisandra henryi Clarke phenol, schisandra chinensis ester, crotonocyl Ge meter Xin.Containing benzoyl Kadsura lignanoid A in stem, isovaleryl Kadsura lignanoid, Radix Angelicae Sinensis acyl Kadsura lignanoid, isobutyryl Kadsura lignanoid, isovaleryl oxo Fructus Schisandrae Sphenantherae alkane, Kadsura lignanoid, Fructus Schisandrae Sphenantherae lactone, Fructus Schisandrae Sphenantherae dilactone, (24z)-3-oxo-12 α-ethyoxyl-8, 24-lanostadiene-26-acid, (24z)-3-oxo-12 Alpha-hydroxy-8, 24-lanostadiene-26-acid, new kadsuric acid B, C, (24z)-3-oxo-8, 24-lanostadiene-26-acid, 3, 4-open loop-(24z)-4(30), 8, 24-Pilus Caprae seu Ovis steroid triolefin-3, 26-diacid.

Containing schisandra chinensis ester J in seed, trimethyl gallic acid, table trimethyl gallic acid, dimethyl removes Radix Angelicae Sinensis acyl schisandra chinensis ester, R(+)-schisandrin C, and Fructus Schisandrae Sphenantherae wood fat is peaceful, R(+)-Ge meter Xin, Radix Angelicae Sinensis acyl Ge meter Xin.

almond oil.micro-Huang is transparent, fragrant taste, is not only a kind of excellent edible oil, or a kind of senior lubricating oil, can the low temperature of resistance to less than-20 DEG C, can be used as the important source material of senior paint, cosmetics and high quality toilet soap, also can extract essence and vitamin.The trace element of almond oil rich in proteins, unsaturated fatty acid, vitamin, inorganic salt, dietary fiber and needed by human body, has lung moistening, stomach invigorating, the effect that regains one's strength of body, the anti-cancer active matter that its amygdalin is natural especially.Its composition comprises: Palmic acid, oleic acid, palmitoleic acid, linoleic acid, stearic acid, left and right linolenic acid, arachic acid and eicosenoic acid.

Almond oil rich in mineral substances, protein and various vitamin, be the splendid vegetable oil of a kind of skin care and moisturizing effect, be applicable to various skin quality.It effectively can alleviate the skin people and to itch phenomenon, eliminates red and swollen, dry and inflammation.The sagging gland of the brain of hormonal system, thymus and adrenal gland can be stimulated, promote cell turnover.

aloe.nature and flavor are bitter; Cold in nature.Return liver; Large intestine channel.The kind of Aloe has: Aloe vulgaris, stripe aloe vera and Aloe ferox Miller.

Aloe is liliaceous plant Aloe vulgaris, is used as medicine with leaf, and bitter in the mouth is cold in nature, returns liver, stomach, large intestine channel.Aloe is mainly containing aloin, different aloin, 7-hydroxyl aloin, 5-hydroxyl aloin A, resin, altheine, aspartic acid, DL-threonine, L-Trp, cholesterol, campesterol, cupreol, lupeol, malic acid, citric acid, tartaric acid, D-Glucose, D-MANNOSE, pectic acid, D-galactan, arabinose and rhamnose.There is eliminating fire and detoxication, effect of blood stasis dispelling parasite killing.

extracting method:

parcel:

Prescription C and prescription D is wrapped up by cyclodextrin derivative by the present invention, then the prescription C after parcel and prescription D and prescription B is carried out polylactic acid coated, finally mixes with prescription A.

Described cyclodextrin derivative is part hydroxypropylation-beta-schardinger dextrin-and partial methylation-beta-schardinger dextrin-.By partial methylation-beta-cyclodextrin inclusion compound prescription C, by part hydroxypropylation-beta-cyclodextrin inclusion compound prescription D.

Described preparation method is:

(1) partial methylation-beta-schardinger dextrin-is dissolved in distilled water and obtains beta-schardinger dextrin-saturated solution, partial methylation-beta-schardinger dextrin-saturated solution heating in water bath is stirred 60-70min to 30-80 DEG C and constant temperature;

(2) under constant temperature stirs, the extract of prescription C is added partial methylation-beta-schardinger dextrin-saturated solution, continue to be uniformly mixed and obtain mixed solution, then ultrasonic enclose is carried out to mixed solution, obtain partial methylation-beta-schardinger dextrin--prescription C enclose solution;

(3) at partial methylation-beta-schardinger dextrin--prescription C enclose solution is placed in 0-10 DEG C, leave standstill 36h, sucking filtration, drying are pressed powder, regrind into fine powder, sieve, to obtain final product.

(4) method of part hydroxypropylation-beta-cyclodextrin inclusion compound prescription D also adopts said method to prepare.

(5) extract of the fine powder of partial methylation-beta-schardinger dextrin--prescription C and part hydroxypropylation-beta-cyclodextrin inclusion compound prescription D and prescription B is mixed, then add second cyanogen, obtain second cyanogen solution;

(6) polylactic acid is added, ultrasonic 5min by above-mentioned second cyanogen solution;

(7) adopted by the solution in step (6) 10KDa super filter tube ultrafiltration 5-6 time with after removing organic solvent and free molecule, namely obtain the prescription B of polylactic acid enclose, partial methylation-beta-schardinger dextrin--prescription C and part hydroxypropylation-beta-cyclodextrin inclusion compound prescription D;

(8) product of step (7) and prescription A are mixed, add water, brown sugar and Mel.

Each beta-schardinger dextrin-is upper 7 glucose residues, and each glucose residue has 3 hydroxyls that can be substituted, therefore the substitution value of beta-schardinger dextrin-is 21 to the maximum, and minimum is 0.When the hydroxyl on beta-schardinger dextrin-is not substituted, substitution value is 0.Described in the present invention, the substitution value of partial methylation-beta-schardinger dextrin-is at 2-10, is preferably 4-8; The substitution value of the hydroxypropylation-beta-schardinger dextrin-of part described in the present invention, at 2-12, is preferably 5-9.

In above-mentioned steps (2), the weight ratio of partial methylation-beta-schardinger dextrin-and prescription C is 1-7:1, is preferably 2-6:1; In above-mentioned steps (4), the weight ratio of part hydroxypropylation-beta-schardinger dextrin-and prescription D is 2-6:1, is preferably 3-5:1.

In above-mentioned steps (6), the weight average molecular weight of polylactic acid is 80,000-12 ten thousand, be preferably 9-11 ten thousand, and the weight ratio of polylactic acid and prescription B is 5-15:1, is preferably 7-12:1.

Embodiment

Hereinafter, by embodiment, the present invention is explained in more detail, but should be understood that these embodiments are only illustrative and nonrestrictive.If do not have other to illustrate, raw materials used is all commercially available.

The present invention is described in detail referring to several example.

Embodiment 1

Treat a medicine for comedo, be made up of prescription A, prescription B, prescription C and prescription D,

Fructus Forsythiae 1, Spica Prunellae 1, Fructus Jujubae 1, Fructus Crataegi 1, Fructus Corni 1;

Radix Scutellariae 1, Herba Violae Hortensis 1, Chinese corktree 1, Rhizoma Solani tuber osi 1, Cedrus deoclar (Roxb.) G. Don quintessence oil 0.1, Semen Cassiae 2, Flos Lonicerae 5, Flos Caryophylli 1, Folium piperis betlis 1;

Radix Asparagi 0.1, olive oil 0.1, rosemary ethereal oil 0.1, Herba Damnacanthi 1, Serissa foetida 1, Fructus Tribuli 1, Herba Centellae 4;

Herba thymi vulgaris 0.1, Camellia sinensis 1, Fructus Citri Limoniae 0.1, Radix Kadsurae longipedunculatae 1, almond oil 5, Aloe 3.

The extracting method of described Radix Scutellariae extract, Fructus Forsythiae extract, Spica Prunellae extract, Fructus Jujubae extract, Fructus Crataegi extract, Fructus Corni extract, Semen Cassiae extract, Radix Asparagi extract is: clean, chopping, first use the explosion of airblasting method, with alcohol reflux again 3-5 time, merge extractive liquid, concentrates and obtains fluid extract.

The extracting method of described Flos Caryophylli extract, Poria extract, Radix Scutellariae extract, Thymi Serpylli Herba extract is: using water as solvent, use ultrasonic extraction 3-6h, concentrates and obtains fluid extract.

The extracting method of described Serissa foetida extract, Fructus Tribuli extract, tea tree extract, almond oil extract is: clean, and Testa Tritici fries 0.5-1h, and temperature is 120-130 DEG C, filter Testa Tritici after cooling, chopping, using ethanol as solvent, use ultrasonic extraction 3-6h, concentrate and obtain fluid extract.

Embodiment 2

Identical with embodiment 1, difference is,

Fructus Forsythiae 8, Spica Prunellae 10, Fructus Jujubae 15, Fructus Crataegi 10, Fructus Corni 12;

Radix Scutellariae 10, Herba Violae Hortensis 15, Chinese corktree 10, Rhizoma Solani tuber osi 3, Cedrus deoclar (Roxb.) G. Don quintessence oil 0.3, Semen Cassiae 10, Flos Lonicerae 10, Flos Caryophylli 8, Folium piperis betlis 7;

Radix Asparagi 0.8, olive oil 3, rosemary ethereal oil 2, Herba Damnacanthi 3, Serissa foetida 8, Fructus Tribuli 2, Herba Centellae 8;

Herba thymi vulgaris 0.7, Camellia sinensis 4, Fructus Citri Limoniae 0.8, Radix Kadsurae longipedunculatae 10, almond oil 10, Aloe 6.

Embodiment 3

Identical with embodiment 1, difference is,

Fructus Forsythiae 6, Spica Prunellae 7, Fructus Jujubae 10, Fructus Crataegi 8, Fructus Corni 10;

Radix Scutellariae 6, Herba Violae Hortensis 12, Chinese corktree 8, Rhizoma Solani tuber osi 2, Cedrus deoclar (Roxb.) G. Don quintessence oil 0.2, Semen Cassiae 8, Flos Lonicerae 8, Flos Caryophylli 6, Folium piperis betlis 5;

Radix Asparagi 0.4, olive oil 2, rosemary ethereal oil 1, Herba Damnacanthi 2, Serissa foetida 6, Fructus Tribuli 1.5, Herba Centellae 6;

Herba thymi vulgaris 0.4, Camellia sinensis 2, Fructus Citri Limoniae 0.5, Radix Kadsurae longipedunculatae 7, almond oil 6, Aloe 5.

Comparative example 1

Identical with embodiment 1, difference is that the material composition of prescription A is not containing Fructus Jujubae extract.

Comparative example 2

Identical with embodiment 1, difference is that the material composition of prescription B is not containing Rhizoma Solani tuber osi extract.

Comparative example 3

Identical with embodiment 1, difference is the material composition Bu Han Folium piperis betlis extract of prescription B.

Comparative example 4

Identical with embodiment 1, difference is that the material composition of prescription B is not containing Chinese corktree extract.

Comparative example 5

Identical with embodiment 1, difference is that the material composition of prescription C is not containing rosemary ethereal oil extract.

Comparative example 6

Identical with embodiment 1, difference is that the material composition of prescription C is not containing Herba Damnacanthi extract.

Comparative example 7

Identical with embodiment 1, difference is that the material composition of prescription C is not containing Radix Asparagi extract.

Comparative example 8

Identical with embodiment 1, difference is that the material composition of prescription D is not containing Radix Kadsurae longipedunculatae extract.

Comparative example 9

Identical with embodiment 1, difference is, the extracting method of Chinese corktree extract is: clean, chopping, then uses acetic acid reflux, extract, 5 times, merge extractive liquid, vacuum drying.

Comparative example 10

Identical with embodiment 1, difference is that the extracting method of ， Folium piperis betlis extract is: clean, chopping, and refined honey mixing post-heating to 55 DEG C, and insulation 4h, using water as solvent after cooling, uses ultrasonic extraction 5h, vacuum drying extracting solution.

Comparative example 11

Identical with embodiment 1, difference is, the extracting method of Semen Cassiae extract is: clean, chopping, by water reflux, extract, 5 times, and merge extractive liquid.

Comparative example 12

Identical with embodiment 1, difference is, the extracting method of Radix Scutellariae extract is: clean, chopping, with water extraction 3-5 time, and merge extractive liquid.

Comparative example 13

Identical with embodiment 1, identical with embodiment 1, difference is, the extracting method of Fructus Tribuli extract is: using water as solvent, use ultrasonic extraction 5h, filters.

evaluation methodology

Select 160 volunteers, male 16 people of age between 18-25 year, women 16 people; Male 16 people of age between 26-30 year, women 16 people; Male 16 people of age between 31-35 year, women 16 people; Male 16 people of age between 36-40 year, women 16 people; Male 16 people of age between 41-45 year, women 16 people.Volunteer's face of selecting all has comedo, and does not use the product of any treatment comedo in previous month of test.Be 1-16 group by 160 volunteer's lacings, often organize 10 people, men and women each 1 people of age between 18-25 year, men and women each 1 people of age between 26-30 year, men and women each 1 people of age between 31-35 year, men and women each 1 people of age between 36-40 year, men and women each 1 people of age between 41-45 year.

1-3 group uses embodiment 1-3 respectively, and 4-16 group uses comparative example 1-13 respectively, and morning, noon and afternoon every day respectively use once, continuously uninterrupted use 180 days.

Opinion rating is divided into A, and comedo disappears completely; B, comedo alleviates about 80%; C, comedo alleviates about 50%; D, comedo does not change.

Therapeutic outcome sees the following form.

As can be seen from test result, the medicine of a kind for the treatment of comedo provided by the invention to suppression propionibacterium acnes, can eliminate scytitis, thorough activating skin.Effective improve 18-45 year each age level the comedo of people, simultaneously containing hormone, environmental protection, provides useful effect.

The above, be only preferred embodiment of the present invention, be not intended to limit protection scope of the present invention.Every equalization done according to content of the present invention changes and modifies, and is all encompassed in the scope of the claims of the present invention.

Claims

1. treat a medicine for comedo, it is characterized in that,

2. the medicine for the treatment of comedo as claimed in claim 1, is characterized in that, by weight,

3. the medicine for the treatment of comedo as claimed in claim 1, is characterized in that, by weight,

4. the medicine for the treatment of comedo as claimed in claim 1, it is characterized in that, the extracting method of described Flos Lonicerae extract, Chinese corktree extract, Herba Centellae extract is: clean, chopping, first use the explosion of airblasting method, then use acetic acid reflux, extract, 3-5 time, merge extractive liquid, vacuum drying, to obtain final product.

5. the medicine for the treatment of comedo as claimed in claim 1, it is characterized in that the extracting method of Suo Shu Folium piperis betlis extract, Herba Damnacanthi extract, Radix Kadsurae longipedunculatae extract is: clean, chopping, and refined honey mixing post-heating is to 45-65 DEG C, insulation 3-5h, using water as solvent after cooling, use ultrasonic extraction 3-6h, vacuum drying extracting solution, to obtain final product.

6. the medicine for the treatment of comedo as claimed in claim 1, it is characterized in that, the extracting method of described Radix Scutellariae extract, Fructus Forsythiae extract, Spica Prunellae extract, Fructus Jujubae extract, Fructus Crataegi extract, Radix Scutellariae extract, Fructus Corni extract, Semen Cassiae extract, Radix Asparagi extract is: clean, chopping, first use the explosion of airblasting method, with alcohol reflux again 3-5 time, merge extractive liquid.

7. the medicine for the treatment of comedo as claimed in claim 1, it is characterized in that, the extracting method of described Flos Caryophylli extract, Poria extract, Thymi Serpylli Herba extract is: using water as solvent, use ultrasonic extraction 3-6h.

8. the medicine for the treatment of comedo as claimed in claim 1, it is characterized in that, the extracting method of described Serissa foetida extract, Fructus Tribuli extract, tea tree extract, almond oil extract is: clean, Testa Tritici fries 0.5-1h, temperature is 120-130 DEG C, filters Testa Tritici after cooling, chopping, using ethanol as solvent, use ultrasonic extraction 3-6h.

9. the medicine for the treatment of comedo as claimed in claim 1, it is characterized in that, described Cedarwood extract, Herba Violae Hortensis extract, Herba Rosmarini Officinalis extract, Aloe extract are obtained by supercritical carbon dioxide extraction, extraction temperature is 30-35 DEG C, extracting pressure is 18-25MPa, resolution temperature is 42-53 DEG C, and parsing pressure is 5-7MPa.

10. prepare the medicine of any one treatment comedo as described in claim 1-9 for one kind, it is characterized in that, the product cyclodextrin derivative of prescription C and prescription D carries out enclose, then the prescription C after enclose and prescription D and prescription B is carried out polylactic acid enclose, finally mixes with prescription A.