CN110227047A - Skin care composition with effect of removing red blood streak and preparation method thereof - Google Patents
Skin care composition with effect of removing red blood streak and preparation method thereof Download PDFInfo
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- CN110227047A CN110227047A CN201910563320.0A CN201910563320A CN110227047A CN 110227047 A CN110227047 A CN 110227047A CN 201910563320 A CN201910563320 A CN 201910563320A CN 110227047 A CN110227047 A CN 110227047A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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Abstract
The invention discloses a skin care composition with the effect of removing red blood streak and a preparation method thereof. The tribulus terrestris extract prepared by the invention contains 5.056-9.084% of total flavonoids compounds of tribulus terrestris and 0.543-2.034% of saponins compounds. The tribulus terrestris extract not only contains total flavonoid components, but also contains saponin components and water-insoluble effective components; the obtained fructus Tribuli extract has remarkable effect of removing red blood streak.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of to have effects that the skin care compositions of red capillary and its preparation
Method.
Background technique
In recent years, the related dermals problem such as red blood trace on face was increasingly becoming the heat of cosmetic industry and medical industries research
Point.Red blood trace on face, medically also known as facial telangiectasias, that is, the elasticity reduction of capillary wall, brittleness increasing
By force, the non-uniform expansion of continuous vessel even ruptures, and causes skin of face general red, the capillary of the visible expansion of naked eyes, often
With red or aubergine plaque-like, it is dotted, linear or starlike phenomena such as, referred to as telangiectasia.Form red blood trace on face
The reason of complicated multiplicity, some familial inheritance diseases cause congenital capillary to relax contracting defect, formation hereditary hemorrhagic capillary
The symptoms such as blood vessel dilatation, spider shape telangiectasis, in addition plateau climate anoxic causes capillary underwent compensatory enlargement to be also
A kind of reason.However, hormonal dependent telangiectasis caused by the abuse of current hormone, especially glucocorticoid becomes
Main cause, specifically, hormone product, which is used for a long time, leads to the collagenous degeneration of local skin, capillary elasticity reduces and becomes
It is crisp, cause telangiectasis, atrophoderma and purpura of local skin etc..
The red capillary that facial telangiectasias causes not only seriously affects patient's appearance, also results in very to the psychology of patient
Big burden.However the creme or finish effect that currently there are a variety of for removing red capillary be not significant, and not up to
The effect that its advertisement is declared.
Part material according to the present invention is described as follows:
Puncture vine (scientific name:Tribulus terrestris L) also known as tribulus terrestris, people etc. is bent, is planted for zygophyllaceae annual herb
Object blazons the whole nation, practises and claims hard puncture vine.Puncturevine herb contains the ingredients such as saponins, flavonoids, amino acids and carbohydrate, in painstaking effort
Guard system and strong, anti-aging, enhancing sexual function etc. show stronger activity.Product development of the total saponins of tribulus in cosmetics
On, it is chiefly used in the exploitation of whitening anti-aging function skin care item.But flavone compound and soap in puncture vine were also not disclosed up to now
Glycosides compound and water-soluble active ingredients can be used for the purposes of red capillary.
Summary of the invention
Have effects that the skin care compositions of red capillary it is an object of the present invention to provide a kind of, mainly contains puncture vine
Extract.
A kind of tribulus fruit extract preparation method, the preparation method include the following steps:
(1) water is added into Fructus tribulus terrestris L, is heated to boiling and decocts 2-4 times, pour out decocting liquid, filter to get filtrate and filter residue；(2)
By gained filtrate concentration in step 1), it is freeze-dried to obtain component A；(3) then ice is added in gained filter residue and drying in step 1) by.
Acetic acid, ultrasonic wave added extraction, filters to get filtrate；(4) gained filtrate decompression evaporation in step (3) is removed into glacial acetic acid, obtains group
B, component A and component B is divided to mix to get tribulus fruit extract is arrived.
In wherein some embodiments, the additional amount of water described in step (1) is 5-10 times of medicinal material weight.
In wherein some embodiments, concentration described in step (2) is to be concentrated into density 1.05-1.20g/ml.
In wherein some embodiments, described in step (3) it is dry for dry or 50-80 DEG C at dry.
In wherein some embodiments, the amount of glacial acetic acid is added described in step (3), makes solid-liquid ratio after glacial acetic acid is added
For 1:(5-20) g/mL.
In wherein some embodiments, the condition of the extraction of ultrasonic wave added described in step (3) are as follows: ultrasonic power 250-300W
Lower Soakage extraction 2-3 times, each 20-40min, temperature is 60-90 DEG C.
In wherein some embodiments, reduction vaporization condition described in step (4) is vacuum degree 0.08-0.1MPa, temperature
It is 70-80 DEG C.
The tribulus fruit extract should include puncture vine Flavonoids and saponins compound, the total flavonoid chemical combination
The content of object is 5.056~9.084%, and the content of the saponin(e is 0.543%~2.034%.Wherein, Flavonoids
Including at least one of Quercetin, kaempferol and Isorhamnetin, the tribulus fruit extract further include it is water-insoluble it is effective at
Point.
A further object of the present invention is disclosed ingredient system common in above-mentioned tribulus fruit extract and skin protection cosmetics
Skin care compositions made of standby, has the function of significantly going red capillary, and the additive amount of the tribulus fruit extract is skincare composition
The 0.01-0.1wt% of object total weight.
Another object of the present invention is the application for disclosing above-mentioned tribulus fruit extract and being gone in red capillary skin care item in preparation.
The present invention has the advantage that and the utility model has the advantages that
1. tribulus fruit extract preparation method of the present invention, by adding water to cook, filtering obtains filtrate and filter residue, concentrating filter liquor obtain
Water soluble ingredient, filter residue obtain water insoluble ingredients using glacial acetic acid, ultrasonic wave added extraction is added, and the two mixing can obtain
To tribulus fruit extract.Preparation method is simple by the present invention, and solvent recovery is easy, and will not pollute；
2. being found through experiments that, water soluble ingredient and water insoluble ingredients two in the tribulus fruit extract that preparation method of the present invention obtains
Person's mixing, has the effect of significantly going red capillary；
3. found by comparative experiments, in the tribulus fruit extract that preparation method of the present invention obtains water soluble ingredient and it is water-insoluble at
When the two being divided to be applied alone, go the effect of red capillary limited.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to
Routine techniques carries out.
Embodiment 1
A kind of tribulus fruit extract, is prepared by the following method:
100kg Fructus tribulus terrestris L is taken, water 500kg is added, is impregnated 30 minutes, heating is boiled 120 minutes, and decocting liquid is poured out, and the dregs of a decoction decoct 1 again
It is secondary, add water 1000kg every time, boil 60 minutes, merges decocting liquid twice, filter to get filtrate；Gained filtrate decompression is concentrated into density
1.05g/ml is freeze-dried to obtain component A；
It is dried at 80 DEG C of filter residue of filtering gained, glacial acetic acid is then added, so that solid-liquid ratio is 1:5g/mL, under ultrasonic power 250W
Soakage extraction 3 times, each 40min, extraction temperature is 90 DEG C；It filters to get filtrate, gained filtrate is in vacuum degree 0.1MPa, temperature
It is evaporated under reduced pressure at 80 DEG C and removes glacial acetic acid, obtained component B, component A and component B and mix to get tribulus fruit extract is arrived.
The yield of tribulus fruit extract be 6.52%, wherein through UV quantitative analysis (method reference literature: Long Fei, Zhou Yuanli, Li Jie,
He Hui, Cheng Feng, Lei Jie, Wei Yingfang Cortex Magnoliae Officinalis general flavone, total starches, total lignan, total tannin and total saponin content measurement [J] are sub-
Too traditional medicine, 2018,14 (07): 25-28.), measuring general flavone content is 9.084%, total saponin content 0.543%.
Embodiment 2
A kind of tribulus fruit extract, is prepared by the following method: taking 100kg Fructus tribulus terrestris L, adds water 1000kg, heating boils 120
Minute, decocting liquid is poured out, the dregs of a decoction are decocted 3 times again, are added water 500kg every time, are boiled 60 minutes, merge 4 decocting liquids, filter to get filtrate；Institute
Obtaining filtrate decompression and being concentrated into density is 1.20g/ml, is freeze-dried to obtain component A；
It is dried at 50 DEG C of filter residue of filtering gained, glacial acetic acid is then added, so that solid-liquid ratio is 1:20g/mL, under ultrasonic power 300W
Soakage extraction 2 times, each 20min, temperature is 60 DEG C；It filters to get filtrate, gained filtrate is in vacuum degree 0.08MPa, temperature 70
It is evaporated under reduced pressure at DEG C and removes glacial acetic acid, obtained component B, component A and component B and mix to get tribulus fruit extract is arrived.
The yield of tribulus fruit extract is 5.63%, wherein through UV quantitative analysis, measuring general flavone content is 5.056%, always
Saponin content 2.034%.
Embodiment 3
A kind of tribulus fruit extract, is prepared by the following method:
100kg Fructus tribulus terrestris L is taken, water 750kg is added, is impregnated 20 minutes, heating is boiled 100 minutes, and decocting liquid is poured out, and the dregs of a decoction decoct 2 again
It is secondary, add water 750kg every time, boils 60 minutes, merge 3 decocting liquids, filter to get filtrate；Gained filtrate decompression is concentrated into density
1.10g/ml is freeze-dried to obtain component A；
Filtering gained filter residue dries, and glacial acetic acid is then added, so that solid-liquid ratio is 1:10g/mL, impregnates and mentions under ultrasonic power 280W
It takes 2 times, each 30min, temperature is 75 DEG C；It filters to get filtrate, for gained filtrate in vacuum degree 0.09MPa, temperature is to subtract at 75 DEG C
Pressure evaporation removes glacial acetic acid, obtains component B, component A and component B and mixes to get tribulus fruit extract is arrived.
The yield of tribulus fruit extract is 6.73%, wherein through UV quantitative analysis, general flavone content 7.013%, total saposins
Content 1.558%.
Application of the tribulus fruit extract in facial treatment milk is as shown in table 1:
Table 1
Experiment 1 improves microcirculation
Sample: experimental group lotion 1-3 of the present invention and control group lotion 4-5.
Application method: experimental group lotion 1-3 and control group lotion 4-5 of the present invention are on probation through 50 red blood trace on face patients,
Age 15-26 years old.50 subjects are divided into 5 groups at random, try out experimental group lotion 1-3 of the present invention and control group lotion 4- respectively
Sample made from 5.Subject directly uses tested products after having cleaned skin, daily to use twice, once in the morning and once at night, dosage
For 0.1g/10cm2.The results are shown in Table 2.
Assess parameter: blood flow takes its average value.
Instrument: DOPPLER-POWER Doppler energy ultrasound.
2 blood flow test result table of table
As can be seen from Table 2, after being compared by experimental group lotion 1-3 of the present invention and control group lotion 4-5 it is found that using lotion of the present invention,
Blood flow is decreased obviously.Tribulus fruit extract of the present invention is applied in lotion to have improves microcirculation effect well, is able to ascend blood
Tube wall elasticity.
2, crowd's test on probation
Experimental group lotion 1-3 and control group lotion 4-5 of the present invention are on probation through 250 red blood trace on face patients, and the age 15-26 years old.
250 subjects are divided into 5 groups at random, try out sample made from experimental group lotion 1-3 of the present invention and control group lotion 4-5 respectively
Product.Application method are as follows: subject directly uses tested products after having cleaned skin, daily to use twice, dosage 0.1g/
10cm2, adhere to, by control of taking pictures using the face picture after preceding and use, the lotion being examined to treat red capillary using 1 month
Effect.The evaluation criterion of curative effect are as follows:
Recovery from illness: red blood trace on face completely disappears；
Improve: red blood trace on face is reduced；
Invalid: red blood trace on face symptom is unchanged or aggravates.
Statistical result such as the following table 3:
Table 3
By above-mentioned 3 data of table it is found that experimental group lotion 1-3 remissive treatment red blood trace on face effective percentage of the present invention up to 82% with
On, it is significant in efficacy, hence it is evident that higher than the effective percentage 20% of control group lotion 4 and the effective percentage 16% of control group lotion 5, and it is all tested
Person has no adverse reaction and generation the case where exacerbation of symptoms.
By experimental group lotion 1-3 of the present invention and control group lotion 4-5 comparison it is found that the preparation side of tribulus fruit extract of the present invention
The tribulus fruit extract that method is prepared is applied in lotion, red capillary effect is gone with excellent, when water-soluble in tribulus fruit extract
When property both ingredient and water insoluble ingredients are applied alone, go the effect of red capillary limited.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (10)
1. a kind of tribulus fruit extract preparation method, which is characterized in that the preparation method includes the following steps:
(1) water is added into Fructus tribulus terrestris L, is heated to boiling and decocts 2-4 times, pour out decocting liquid, filter to get filtrate and filter residue；
(2) gained filtrate in step 1) is concentrated, is freeze-dried to obtain component A；
(3) then glacial acetic acid is added in gained filter residue and drying in step 1) by., and ultrasonic wave added extraction filters to get filtrate；
(4) gained filtrate decompression evaporation in step (3) is removed into glacial acetic acid, obtain component B, component A and component B mix to get
To tribulus fruit extract.
2. tribulus fruit extract preparation method according to claim 1, which is characterized in that the addition of water described in step (1)
Amount is 5-10 times of medicinal material weight.
3. tribulus fruit extract preparation method according to claim 1, which is characterized in that concentration described in step (2) is dense
It is reduced to density 1.05-1.20g/ml.
4. tribulus fruit extract preparation method according to claim 1, which is characterized in that dry described in step (3) is to dry in the air
It is dry or 50-80 DEG C at dry.
5. tribulus fruit extract preparation method according to claim 1, which is characterized in that ice vinegar is added described in step (3)
The amount of acid makes solid-liquid ratio be 1:(5-20 after glacial acetic acid is added) g/mL.
6. tribulus fruit extract preparation method according to claim 1, which is characterized in that ultrasonic wave added described in step (3)
The condition of extraction are as follows: Soakage extraction 2-3 times under ultrasonic power 250-300W, each 20-40min, temperature are 60-90 DEG C.
7. tribulus fruit extract preparation method according to claim 1, which is characterized in that be evaporated under reduced pressure described in step (4)
Condition is vacuum degree 0.08-0.1MPa, and temperature is 70-80 DEG C.
8. the tribulus fruit extract that tribulus fruit extract preparation method obtains described in -7 according to claim 1.
9. tribulus fruit extract according to claim 8, which is characterized in that the tribulus fruit extract should include puncture vine general flavone
Class compound and saponins compound, the content of the Flavonoids are 5.056~9.084%, and the saponin(e contains
Amount is 0.543%~2.034%；Wherein, Flavonoids include at least one in Quercetin, kaempferol and Isorhamnetin
Kind, the tribulus fruit extract further includes water-insoluble effective component.
10. tribulus fruit extract according to claim 8, which is characterized in that the tribulus fruit extract and skin protection cosmetics
In the skin care compositions that is prepared of common ingredient, the additive amount of the tribulus fruit extract is the 0.01- of skin care item total weight
0.1wt%。
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Effective date of registration: 20231005 Address after: Room 1906, 19th floor, building 2, Greenland Huichuang Plaza, no.6, Kexing Road, Guangzhou private science and Technology Park, no.1633 Beitai Road, Baiyun District, Guangzhou, Guangdong 510000 Patentee after: Guangzhou Ding Pine Biotechnology Co.,Ltd. Address before: 510000 No. 58, chentai Road, Taihe, Baiyun District, Guangzhou, Guangdong Patentee before: Guangzhou Sanguang Biotechnology Co.,Ltd. |