CN103751074B - Compound traditional Chinese medicine extract with effect of removing red blood silk, and application - Google Patents
Compound traditional Chinese medicine extract with effect of removing red blood silk, and application Download PDFInfo
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- CN103751074B CN103751074B CN201410065878.3A CN201410065878A CN103751074B CN 103751074 B CN103751074 B CN 103751074B CN 201410065878 A CN201410065878 A CN 201410065878A CN 103751074 B CN103751074 B CN 103751074B
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Abstract
The invention discloses a compound traditional Chinese medicine with an effect of removing red blood silk. The compound traditional Chinese medicine is characterized by comprising the following raw materials weight percentage: 10-40% of mung bean, 10-40% of radix rehmanniae recen, 1-30% of grape pip, 5-30% of witch hazel and 1-25% of liquorice. A preparation method of a compound traditional Chinese medicine extract comprises the steps that the traditional Chinese medicine raw materials, namely the mung bean, the radix rehmanniae recen, the grape pip, the witch hazel and the liquorice are weighed according to a ratio, appropriately smashed, mixed, added to an extracting solvent, and soaked for 1-2h together with the extracting solvent; extraction is performed by a high-pressure homogenizing extractor; an extracting solution is centrifugally separated, depressurized and condensed; purification is performed by a macroporous resin column; a 30-80% alcohol elution part is collected; depressurizion and condensation are performed until a mass ratio of the extracting solution to the medicinal materials is (1:0.5)-(1:10); 10-60% butanediol is added for dissolution; filtering is performed; and the compound traditional Chinese medicine extract is prepared. The compound traditional Chinese medicine extract obtained by the method has beautifying effects of effectively removing the red blood silk and delaying skin senescence.
Description
Technical field
The present invention relates to a kind of herbal mixture, specifically a kind of have dispel the compound Chinese medicine extract of red blood trace on face effect and the application in cosmetics.
Background technology
Red blood streak mainly because facial telangiectasias or a part of blood capillary position more shallow and occur facial phenomenon, red blood trace on face patient face looks than normally the colour of skin is red, and some red blood streak patients are only that cheekbone portion, both sides is rubescent, and border is rounded.This skin is thin and responsive, and when supercool, overheated, excited, face is redder.What situation was serious also can form deposition mottle, is difficult to cure.Not only affecting external, causing shade, to bringing very large inconvenience orthobiosis also can to its psychology.
The reason of red blood trace on face is caused roughly to divide two large types: genotype and bring out type.Mostly genotype is familial heredity, and bring out type the most common, Producing reason mainly contains following several: (1) local life-time service corticoid medicine, causes telangiectasis, cause thinning of skin, atrophy etc.; (2) blood circulation is obstructed, and blood vessel wall is retarded by silt and is made face present a rule red blood streak; (3) misuse is containing hormone or pharmaceutical compositions skin care item, photon delicate skin, and fruit acid changes the exfoliation treatments such as skin makes keratodermatitis thinning transparent, easily forms red blood streak; (4) itself be sensitive skin, stimulate sensitivity to external world, cause not slightly blood vessel time tight time pine, present congestion state repeatedly, cause the roundabout expansion of blood vessel, formed red blood streak.
The method of current treatment red blood streak mainly contains several as follows: (1) instrument treatment: as adopted the method for laser and the treatment of cold light quantum skin care, enforceablely disposablely dispel red blood streak, this method runs counter to the natural law that skin generates metabolism more, easily cause the ossified of blood capillary, or even cause caking and pigmentation, and easily recur.(2) oral Chinese medicine treatment: be medicine three points of poison, effect of Chinese medicine has multiformity, can not accurately define effective active component, lack modernization biotechnology, part Chinese medicinal ingredients also can cause allergy.(3) external hormone unguentum: it can rapid relief of symptoms at short notice, but this kind of medicine has side effect large, and the raw dependency of fecund, symptom is by recurrent exerbation, and skin is more responsive.
Along with the raising of people's living standard, people are also improving constantly the requirement of beautifying skin quality, while emphasis effect, pay much attention to safety.The Red blood streak dispelling cosmetics that development effectiveness is obvious, safe, become the focus of current beauty industry, and the active Chinese drug component thing of plant origin are its mains direction of studying.
Summary of the invention
Object of the present invention is just to provide a kind of natural, safe compound Chinese medicine extract with Red blood streak dispelling effect.
To achieve the object of the present invention, present invention employs following technical scheme:
There is the herbal mixture of Red blood streak dispelling effect, it is characterized in that the component comprising following percentage by weight: Semen phaseoli radiati 10-40%, Radix Rehmanniae 10-40%, Semen Vitis viniferae 1-30%, Radix Hamamelidis Mollis 5-30%, Radix Glycyrrhizae 1-25%.
The above-mentioned preparation method with the compound Chinese medicine extract of Red blood streak dispelling effect, it is characterized in that: take raw material of Chinese medicine Semen phaseoli radiati by proportioning, Radix Rehmanniae, Semen Vitis viniferae, Radix Hamamelidis Mollis, Radix Glycyrrhizae, suitable pulverizing, mixing, add Extraction solvent, soak 1 ~ 2h together with Extraction solvent after, extract with high pressure homogenization method machine, extracting solution is through centrifugalize, after concentrating under reduced pressure, go up macroporous resin column purification again, collect the ethanol elution part that mass fraction is 30%-80%, being evaporated to extracting solution with quality of medicinal material ratio is 1: 0.5 ~ 1: 10, add the butanediol dissolving that mass fraction is 10%-60%, filter, obtained compound Chinese medicine extract, Extraction solvent is water, ethanol, alcohol-water mixed solution.
The second object of the present invention is used in cosmetics by the above-mentioned compound Chinese medicine extract with Red blood streak dispelling effect, makes stable in properties, respond well Red blood streak dispelling cosmetics.
For realizing the second object of the present invention, present invention employs following technical scheme: above-mentioned compound Chinese medicine extract is used for preparing cosmetics, it is characterized in that its consumption is 0.01-25%, and preferable amount is 1-10% containing above-mentioned compound Chinese medicine extract in cosmetics.
The invention has the beneficial effects as follows: the present invention carries out the design of herbal mixture according to the theory of Chinese medical science of monarch, and the Semen phaseoli radiati in herbal mixture of the present invention is cool in nature, having the effect reducing capillary permeability, is monarch drug; Radix Rehmanniae has clearing away heat and cooling blood function, thus makes blood capillary reply normal microcirculation, is ministerial drug; Semen Vitis viniferae and Radix Hamamelidis Mollis are adjuvant drug, and grape polyphenols contained in Semen Vitis viniferae, except strengthening the elasticity of blood vessel, outside blood circulation promoting, strengthens skin simultaneously in addition
collagen protein, the effect of the many-side such as the vigor of elastin laminin; Radix Hamamelidis Mollis can be alleviated the stimulation of blood capillary and strengthen skin barrier, has and effectively repairs red blood streak effect.Radix Glycyrrhizae contains the flavones ingredients such as Sang Su, has potent elimination free radical, has effect of extraordinary reparation damaged tissues cell, desalination cicatrix, inducing diuresis to remove edema, and has extraordinary coordinating the actions of various ingredients in a prescription ability.All medicines share above, can Synergistic, reach the skin care object dispelling red blood streak, delaying skin aging.
Detailed description of the invention
Below by way of specific embodiment, the present invention is further illustrated, but these embodiments are just in order to illustrate, are not limitations of the present invention.
the preparation of embodiment 1 compound Chinese medicine extract (I)
Get Semen phaseoli radiati 30g, Radix Rehmanniae 25g, Semen Vitis viniferae 8g, Radix Hamamelidis Mollis 25g, Radix Glycyrrhizae 12g, suitably pulverize, mixing, add the ethanol 2L that mass fraction is 50%, after soaking 1 ~ 2h, extract with high pressure homogenization method machine, extracting solution, through centrifugalize, is evaporated to without alcohol taste.Above extracting solution goes up AB-8 macroporous resin column purification again, and collect the ethanol elution part that mass fraction is 70%, under 60 DEG C of conditions, concentrating under reduced pressure obtains 80mL concentrated solution, then adds 20mL butanediol, filters, obtained 100mL herbal mixture extracting solution.
embodiment 2
the preparation of compound Chinese medicine extract (II)
Get Semen phaseoli radiati 25g, Radix Rehmanniae 25g, Semen Vitis viniferae 15g, Radix Hamamelidis Mollis 15g, Radix Glycyrrhizae 20g, suitably pulverize, mixing, add the ethanol 2L that mass fraction is 30%, after soaking 1 ~ 2h, extract with high pressure homogenization method machine, extracting solution, through centrifugalize, is evaporated to without alcohol taste.Above extracting solution goes up AB-8 macroporous resin column purification again, and collect the ethanol elution part that mass fraction is 60%, under 60 DEG C of conditions, concentrating under reduced pressure obtains 70mL concentrated solution, then adds 30mL butanediol, filters, obtained 100mL herbal mixture extracting solution.
embodiment 3 Red blood streak dispelling nourishing cream
Table 1 provides the Red blood streak dispelling nourishing cream formula containing compound Chinese medicine extract of the present invention.
Table 1
Preparation method: A phase 80 DEG C dissolves mix homogeneously, B phase 80 DEG C dissolves mix homogeneously, adds B phase before Cyclomethicone emulsifying, and during emulsifying, B is added to A phase also homogenizing 5min, adds C phase also homogenizing 2 minutes, pack after ageing 24h when being cooled to 50 DEG C.
the common cream frost of comparative example 1
Table 2 provides the common cream frost formula not containing compound Chinese medicine extract of the present invention.
Table 2
Preparation method: A phase 80 DEG C dissolves mix homogeneously, B phase 80 DEG C dissolves mix homogeneously, adds B phase before Cyclomethicone emulsifying, and during emulsifying, B is added to A phase also homogenizing 5min, adds C phase also homogenizing 2 minutes, pack after ageing 24h when being cooled to 50 DEG C.
embodiment 4 normal individual trial evaluation experimental
1, experimental technique
Cream frost prepared by embodiment 3 and comparative example 1 carries out normal individual trial evaluation respectively.The volunteer 30 that the Pass Test choosing 30-50 year requires, is women, all has red blood trace on face symptom to a certain degree.Using method is use after clean of every day, twice daily (sooner or later respectively once), and left face uses the Red blood streak dispelling nourishing cream prepared by embodiment 3, and right face uses the common cream frost pressed comparative example 1 and prepare.Experiment periods is two months, measures the red pigment value of left face and right face after two months before using with use.
2, evaluation criterion
Test instrunment: Mexamter MX18 (CK Electronic GmH, Germany)
Test request: room temperature less than 20 ± 2 DEG C, relative humidity (R H) less than 50 ± 5%; Testee before the assay 30min enters in test environment quiet to be measured, and tested position is exposed by 10min before the assay.
Method of testing: according to test request, chooses the suitable area (1.5cm × 1.5cm) of the facial left and right cheek of testee as being tested district.The probe vertical of Mexamter MX18 is placed on skin, after 3s ~ 5s, after value stabilization to be determined, reads the red pigment value at tested position.Within the scope of cheek skin 1.5cm × 1.5cm, get 5 some tests, average.
Evaluation criterion: the red pigment before and after being used by test suppresses situation (suppression ratio) to judge Red blood streak dispelling effect, and the computational methods of suppression ratio are shown in shown in following formula:
Suppression ratio=(before using the rear red pigment value of red pigment value-use) × 100%/use front red pigment value
Remarkable result: suppression ratio >=20%
Effective: suppression ratio=5% ~ 20%
Invalid: suppression ratio <5%
3, evaluation result
Evaluation result is shown in Table 3.
Table 3
| Sample | Obvious effective rate | Effective percentage | Inefficiency |
| Embodiment 3 | 66.7 | 26.7 | 6.6 |
| Comparative example 1 | 0 | 6.7 | 93.3 |
Use and investigate 30 volunteers after two months, wherein think and reach 66.7% to the ratio that the red pigment suppression ratio of face has a remarkable result, think effectively have 26.7%, total effective rate reaches 93.4%.Therefore, the sample that prepared by embodiment 3 is a kind of respond well Red blood streak dispelling nourishing cream.
Claims (3)
1. there is the herbal mixture of Red blood streak dispelling effect, it is characterized in that being made up of following weight percent composition: Semen phaseoli radiati 10-40%, Radix Rehmanniae 10-40%, Semen Vitis viniferae 1-30%, Radix Hamamelidis Mollis 5-30%, Radix Glycyrrhizae 1-25%.
2. the preparation method of the herbal mixture described in claim 1 is: take raw material of Chinese medicine Semen phaseoli radiati by proportioning, Radix Rehmanniae, Semen Vitis viniferae, Radix Hamamelidis Mollis, Radix Glycyrrhizae, suitable pulverizing, mixing, add Extraction solvent, soak 1 ~ 2h together with Extraction solvent after, extract with high pressure homogenization method machine, extracting solution is through centrifugalize, after concentrating under reduced pressure, go up macroporous resin column purification again, collect the ethanol elution part that mass fraction is 30%-80%, being evaporated to extracting solution with quality of medicinal material ratio is 1: 0.5 ~ 1: 10, add the butanediol dissolving that mass fraction is 10%-60%, filter, obtained herbal mixture, Extraction solvent is water, ethanol, ethanol-water mixed solution.
3. the application of the herbal mixture described in claim 1 in preparing cosmetics, is characterized in that its consumption is 0.01-25% containing the herbal mixture described in claim 1 in cosmetics.
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| CN105168091A (en) * | 2015-09-30 | 2015-12-23 | 青岛海之源智能技术有限公司 | Telangiectasis removing mask powder and preparation method thereof |
| CN106236676B (en) * | 2016-10-23 | 2021-04-06 | 广州市孝真生物科技有限公司 | Plant composition with anti-aging effect and application thereof |
| CN107362244A (en) * | 2017-07-04 | 2017-11-21 | 合肥丰瑞隆生物科技有限公司 | A kind of Eradicates removes the Chinese medical extract and its external preparation of red blood trace on face |
| CN111686179B (en) * | 2020-06-15 | 2021-09-10 | 广州市衡拓贸易有限公司 | Traditional Chinese medicine compound extract with acne removing and red blood streak removing effects and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102397175A (en) * | 2010-09-10 | 2012-04-04 | 北京工商大学 | Chinese medicinal extract for eliminating face red blood streaks and preparation method and application thereof |
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| JP2000229827A (en) * | 1999-02-05 | 2000-08-22 | Kose Corp | Skin lotion |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102397175A (en) * | 2010-09-10 | 2012-04-04 | 北京工商大学 | Chinese medicinal extract for eliminating face red blood streaks and preparation method and application thereof |
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| 刘红丹.如何食疗治愈面部"红血丝".《健康生活一本通》.江西科学技术出版社,2012,第216页. * |
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Owner name: GUANGZHOU ZELI PHARMATECH CO., LTD. Effective date: 20150421 |
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Effective date of registration: 20150421 Address after: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Patentee after: Guangdong Industry Technical College Patentee after: Guangzhou Ze force Pharmaceutical Co. Ltd. Address before: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Patentee before: Guangdong Industry Technical College |
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Inventor after: Gong Shengzhao Inventor after: Song Lifei Inventor after: Liu Changqing Inventor before: Gong Shengzhao |
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Address after: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Patentee after: Guangdong Industry Technical College Patentee after: Zeli Medicine Tech Co., Ltd., Guangzhou Address before: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Patentee before: Guangdong Industry Technical College Patentee before: Guangzhou Ze force Pharmaceutical Co. Ltd. |