CN103751074A - Compound traditional Chinese medicine extract with effect of removing red blood silk, and application - Google Patents
Compound traditional Chinese medicine extract with effect of removing red blood silk, and application Download PDFInfo
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- CN103751074A CN103751074A CN201410065878.3A CN201410065878A CN103751074A CN 103751074 A CN103751074 A CN 103751074A CN 201410065878 A CN201410065878 A CN 201410065878A CN 103751074 A CN103751074 A CN 103751074A
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Abstract
The invention discloses a compound traditional Chinese medicine with an effect of removing red blood silk. The compound traditional Chinese medicine is characterized by comprising the following raw materials weight percentage: 10-40% of mung bean, 10-40% of radix rehmanniae recen, 1-30% of grape pip, 5-30% of witch hazel and 1-25% of liquorice. A preparation method of a compound traditional Chinese medicine extract comprises the steps that the traditional Chinese medicine raw materials, namely the mung bean, the radix rehmanniae recen, the grape pip, the witch hazel and the liquorice are weighed according to a ratio, appropriately smashed, mixed, added to an extracting solvent, and soaked for 1-2h together with the extracting solvent; extraction is performed by a high-pressure homogenizing extractor; an extracting solution is centrifugally separated, depressurized and condensed; purification is performed by a macroporous resin column; a 30-80% alcohol elution part is collected; depressurizion and condensation are performed until a mass ratio of the extracting solution to the medicinal materials is (1:0.5)-(1:10); 10-60% butanediol is added for dissolution; filtering is performed; and the compound traditional Chinese medicine extract is prepared. The compound traditional Chinese medicine extract obtained by the method has beautifying effects of effectively removing the red blood silk and delaying skin senescence.
Description
Technical field
The present invention relates to a kind of herbal mixture, specifically a kind of have dispel the compound Chinese medicine extract of red blood trace on face effect and the application in cosmetics.
Background technology
Red blood streak be mainly because facial telangiectasias or a part of blood capillary position compared with facial phenomenon shallow and that occur, red blood trace on face patient face looks redder than the general normal colour of skin, and some red blood streak patients are only that both sides cheekbone portion is rubescent, and border is rounded.This skin is thin and responsive, and when supercool, overheated, excited, face is redder.What situation was serious also can form deposition mottle, is difficult to cure.Not only affect external, cause shade also can to its psychology, to bringing very large inconvenience orthobiosis.
The reason that causes red blood trace on face is roughly divided two large types: genotype and bring out type.Mostly genotype is familial heredity, brings out type the most common, and the reason of generation mainly contains following several: (1) local life-time service corticoid medicine, cause telangiectasis, and cause thinning of skin, atrophy etc.; (2) blood circulation is obstructed, and blood vessel wall is retarded by silt and is made face present a rule red blood streak; (3) misuse contains hormone or pharmaceutical compositions skin care item, photon delicate skin, and fruit acid changes the exfoliation treatments such as skin makes keratodermatitis attenuation transparent, easily forms red blood streak; (4) itself be sensitive skin, stimulate to external world responsively, pine when tight while causing not slightly blood vessel, presents congestion state repeatedly, causes the roundabout expansion of blood vessel, forms red blood streak.
The method for the treatment of red blood streak mainly contains several as follows at present: (1) instrument treatment: as adopted the method for laser and the treatment of cold light quantum skin care, the enforceable disposable red blood streak of dispelling, this method is run counter to the natural law that skin generates metabolism more, easily cause the ossified of blood capillary, or even cause caking and pigmentation, and easily recurrence.(2) oral Chinese medicine treatment: be three minutes poison of medicine, the effect of Chinese medicine has multiformity, can not accurately define effective active component, lacks modernization biotechnology, and part Chinese medicinal ingredients also can cause allergy.(3) external hormone unguentum: it is rapid recovery symptom at short notice, but this class medicine has side effect large, the raw dependency of fecund, symptom will be shown effect repeatedly, and skin is more responsive.
Along with the raising of people's living standard, people are also improving constantly the requirement of beautifying skin quality, pay much attention to safety in emphasis effect.The Red blood streak dispelling cosmetics that development effectiveness is obvious, safe, become the focus of current beauty industry, and the active Chinese drug component thing of plant origin are its mains direction of studying.
Summary of the invention
Object of the present invention is just to provide a kind of natural, safe compound Chinese medicine extract with Red blood streak dispelling effect.
To achieve the object of the present invention, the present invention has adopted following technical scheme:
The herbal mixture with Red blood streak dispelling effect, is characterized in that the component that comprises following percentage by weight: Semen phaseoli radiati 10-40%, Radix Rehmanniae 10-40%, Semen Vitis viniferae 1-30%, Radix Hamamelidis Mollis 5-30%, Radix Glycyrrhizae 1-25%.
The above-mentioned preparation method with the compound Chinese medicine extract of Red blood streak dispelling effect, it is characterized in that: by proportioning, take raw material of Chinese medicine Semen phaseoli radiati, Radix Rehmanniae, Semen Vitis viniferae, Radix Hamamelidis Mollis, Radix Glycyrrhizae, suitably pulverize, mix, add extraction solvent, soak after 1 ~ 2h together with extracting solvent, with high pressure homogenize extractor, extract, extracting solution is through centrifugalize, after concentrating under reduced pressure, go up again macroporous resin column purification, the ethanol elution part that collection mass fraction is 30%-80%, being evaporated to extracting solution is 1: 0.5～1: 10 with quality of medicinal material ratio, adding mass fraction is the butanediol dissolving of 10%-60%, filter, make compound Chinese medicine extract, extraction solvent is water, ethanol, alcohol-water mixed solution.
The second object of the present invention be by the above-mentioned compound Chinese medicine extract with Red blood streak dispelling effect for cosmetics, make stable in properties, respond well Red blood streak dispelling cosmetics.
For realizing the second object of the present invention, the present invention has adopted following technical scheme: above-mentioned compound Chinese medicine extract, for preparing cosmetics, be is characterized in that containing above-mentioned compound Chinese medicine extract in cosmetics, and its consumption is 0.01-25%, and preferable amount is 1-10%.
The invention has the beneficial effects as follows: the present invention carries out the design of herbal mixture according to the theory of Chinese medical science of monarch, the Semen phaseoli radiati in herbal mixture of the present invention is cool in nature to have the effect that reduces capillary permeability, is monarch drug; Radix Rehmanniae has clearing away heat and cooling blood function, thereby makes blood capillary reply normal microcirculation, is ministerial drug; Semen Vitis viniferae and Radix Hamamelidis Mollis are adjuvant drug, and grape polyphenols contained in Semen Vitis viniferae, except strengthening the elasticity of blood vessel, outside blood circulation promoting, strengthens skin simultaneously in addition
collagen protein, many-sided effect such as the vigor of elastin laminin; Radix Hamamelidis Mollis can be alleviated the stimulation of blood capillary and strengthen skin barrier, has the effect of effective reparation red blood streak.Radix Glycyrrhizae contains the flavones ingredients such as Sang Su, has potent elimination free radical, has the effect of extraordinary reparation damaged tissues cell, desalination cicatrix, inducing diuresis to remove edema, and has extraordinary coordinating the actions of various ingredients in a prescription ability.All medicines share above, can Synergistic, reach the skin care object of dispelling red blood streak, delaying skin aging.
The specific embodiment
By specific embodiment, come below that the present invention is further illustrated, but these embodiment are just in order to illustrate, are not limitations of the present invention.
the preparation of embodiment 1 compound Chinese medicine extract (I)
Get Semen phaseoli radiati 30g, Radix Rehmanniae 25g, Semen Vitis viniferae 8g, Radix Hamamelidis Mollis 25g, Radix Glycyrrhizae 12g, suitably pulverize, mix, adding mass fraction is 50% ethanol 2L, soaks after 1 ~ 2h, with high pressure homogenize extractor, extracts, extracting solution, through centrifugalize, is evaporated to without alcohol taste.Above extracting solution is gone up AB-8 macroporous resin column purification again, the ethanol elution part that collection mass fraction is 70%, and under 60 ℃ of conditions, concentrating under reduced pressure obtains 80mL concentrated solution, then adds 20mL butanediol, filters, and makes 100mL herbal mixture extracting solution.
embodiment 2?
the preparation of compound Chinese medicine extract (II)
Get Semen phaseoli radiati 25g, Radix Rehmanniae 25g, Semen Vitis viniferae 15g, Radix Hamamelidis Mollis 15g, Radix Glycyrrhizae 20g, suitably pulverize, mix, adding mass fraction is 30% ethanol 2L, soaks after 1 ~ 2h, with high pressure homogenize extractor, extracts, extracting solution, through centrifugalize, is evaporated to without alcohol taste.Above extracting solution is gone up AB-8 macroporous resin column purification again, the ethanol elution part that collection mass fraction is 60%, and under 60 ℃ of conditions, concentrating under reduced pressure obtains 70mL concentrated solution, then adds 30mL butanediol, filters, and makes 100mL herbal mixture extracting solution.
embodiment 3 Red blood streak dispelling nourishing cream
Table 1 provides the Red blood streak dispelling nourishing cream formula that contains compound Chinese medicine extract of the present invention.
Table 1
Preparation method: A is 80 ℃ of dissolving mix homogeneously mutually, and B is 80 ℃ of dissolving mix homogeneously mutually, add B phase before Cyclomethicone emulsifying, and during emulsifying, B is added to A mutually and homogenizing 5min, adds C phase homogenizing 2 minutes while being cooled to 50 ℃, after ageing 24h, pack.
the common cream frost of comparative example 1
Table 2 provides the common cream frost formula that does not contain compound Chinese medicine extract of the present invention.
Table 2
Preparation method: A is 80 ℃ of dissolving mix homogeneously mutually, and B is 80 ℃ of dissolving mix homogeneously mutually, add B phase before Cyclomethicone emulsifying, and during emulsifying, B is added to A mutually and homogenizing 5min, adds C phase homogenizing 2 minutes while being cooled to 50 ℃, after ageing 24h, pack.
embodiment 4 human bodies are tried out evaluation experimental
1, experimental technique
The cream frost of embodiment 3 and comparative example 1 preparation carries out respectively human body evaluation on probation.Choose 30 of the volunteers that the Pass Test in 30-50 year requires, be women, all have red blood trace on face symptom to a certain degree.Using method is to use after clean of every day, and twice of every day (sooner or later each once), left face is used the Red blood streak dispelling nourishing cream of press embodiment 3 preparations, and right face is used by the common cream of comparative example 1 preparation white.Experimental period is two months, measures after two months the red pigment value of left face and right face before using with use.
2, evaluation criterion
Test instrunment: Mexamter MX18 (CK Electronic GmH, Germany)
Test request: room temperature is below 20 ± 2 ℃, and relative humidity (R H) is below 50 ± 5%; Testee 30min before mensuration enters in test environment quiet to be measured, and before mensuration, 10min exposes tested position.
Method of testing: according to test request, choose the suitable area (1.5cm * 1.5cm) of testee's facial left and right cheek as Bei Yan district.By the probe vertical of Mexamter MX18 be placed on skin, after 3s～5s, after value stabilization to be determined, read the red pigment value at tested position.Within the scope of cheek skin 1.5cm * 1.5cm, get 5 some tests, average.
Evaluation criterion: the red pigment before and after using by test suppresses situation (suppression ratio) and judges Red blood streak dispelling effect, and the computational methods of suppression ratio are shown in shown in following formula:
Suppression ratio=(the rear red pigment value of red pigment value-use before using) * 100%/red pigment value before using
Remarkable result: suppression ratio >=20%
Effective: suppression ratio=5% ~ 20%
Invalid: suppression ratio <5%
3, evaluation result
Evaluation result is shown in Table 3.
Table 3
| Sample | Obvious effective rate | Effective percentage | Inefficiency |
| Embodiment 3 | 66.7 | 26.7 | 6.6 |
| Comparative example 1 | 0 | 6.7 | 93.3 |
Use and after two months 30 volunteers to be investigated, wherein think that the ratio that facial red pigment suppression ratio is had to a remarkable result has reached 66.7%, think and effectively have 26.7%, total effective rate reaches 93.4%.Therefore, the sample of embodiment 3 preparations is a kind of respond well Red blood streak dispelling nourishing cream.
Claims (3)
1. a herbal mixture with Red blood streak dispelling effect, is characterized in that the component that comprises following percentage by weight: Semen phaseoli radiati 10-40%, Radix Rehmanniae 10-40%, Semen Vitis viniferae 1-30%, Radix Hamamelidis Mollis 5-30%, Radix Glycyrrhizae 1-25%, the preparation method of the extract of herbal mixture is: by proportioning, take raw material of Chinese medicine Semen phaseoli radiati, Radix Rehmanniae, Semen Vitis viniferae, Radix Hamamelidis Mollis, Radix Glycyrrhizae, suitably pulverize, mix, add extraction solvent, soak after 1 ~ 2h together with extracting solvent, with high pressure homogenize extractor, extract, extracting solution is through centrifugalize, after concentrating under reduced pressure, go up again macroporous resin column purification, the ethanol elution part that collection mass fraction is 30%-80%, being evaporated to extracting solution is 1: 0.5～1: 10 with quality of medicinal material ratio, adding mass fraction is the butanediol dissolving of 10%-60%, filter, make compound Chinese medicine extract, extraction solvent is water, ethanol, alcohol-water mixed solution.
2. the preparation method of the extract of herbal mixture claimed in claim 1 is: by proportioning, take raw material of Chinese medicine Semen phaseoli radiati, Radix Rehmanniae, Semen Vitis viniferae, Radix Hamamelidis Mollis, Radix Glycyrrhizae, suitably pulverize, mix, add extraction solvent, soak after 1 ~ 2h together with extracting solvent, with high pressure homogenize extractor, extract, extracting solution is through centrifugalize, after concentrating under reduced pressure, go up again macroporous resin column purification, the ethanol elution part that collection mass fraction is 30%-80%, being evaporated to extracting solution is 1: 0.5～1: 10 with quality of medicinal material ratio, adding mass fraction is the butanediol dissolving of 10%-60%, filter, make compound Chinese medicine extract, extraction solvent is water, ethanol, alcohol-water mixed solution.
3. the application of the extract of herbal mixture claimed in claim 1 in preparing cosmetics, is characterized in that containing above-mentioned compound Chinese medicine extract in cosmetics, and its consumption is 0.01-25%, and preferable amount is 1-10%.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105168091A (en) * | 2015-09-30 | 2015-12-23 | 青岛海之源智能技术有限公司 | Telangiectasis removing mask powder and preparation method thereof |
| CN106236676A (en) * | 2016-10-23 | 2016-12-21 | 广东轻工职业技术学院 | A kind of vegetable composition with senile-resistant efficacy and application thereof |
| CN107362244A (en) * | 2017-07-04 | 2017-11-21 | 合肥丰瑞隆生物科技有限公司 | A kind of Eradicates removes the Chinese medical extract and its external preparation of red blood trace on face |
| CN111686179A (en) * | 2020-06-15 | 2020-09-22 | 广东轻工职业技术学院 | Traditional Chinese medicine compound extract with acne removing and red blood streak removing effects and preparation and application thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168091A (en) * | 2015-09-30 | 2015-12-23 | 青岛海之源智能技术有限公司 | Telangiectasis removing mask powder and preparation method thereof |
| CN106236676A (en) * | 2016-10-23 | 2016-12-21 | 广东轻工职业技术学院 | A kind of vegetable composition with senile-resistant efficacy and application thereof |
| CN106236676B (en) * | 2016-10-23 | 2021-04-06 | 广州市孝真生物科技有限公司 | Plant composition with anti-aging effect and application thereof |
| CN107362244A (en) * | 2017-07-04 | 2017-11-21 | 合肥丰瑞隆生物科技有限公司 | A kind of Eradicates removes the Chinese medical extract and its external preparation of red blood trace on face |
| CN111686179A (en) * | 2020-06-15 | 2020-09-22 | 广东轻工职业技术学院 | Traditional Chinese medicine compound extract with acne removing and red blood streak removing effects and preparation and application thereof |
| CN111686179B (en) * | 2020-06-15 | 2021-09-10 | 广州市衡拓贸易有限公司 | Traditional Chinese medicine compound extract with acne removing and red blood streak removing effects and application thereof |
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| CN103751074B (en) | 2015-04-22 |
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Owner name: GUANGZHOU ZELI PHARMATECH CO., LTD. Effective date: 20150421 |
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Effective date of registration: 20150421 Address after: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Patentee after: Guangdong Industry Technical College Patentee after: Guangzhou Ze force Pharmaceutical Co. Ltd. Address before: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Patentee before: Guangdong Industry Technical College |
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Inventor after: Gong Shengzhao Inventor after: Song Lifei Inventor after: Liu Changqing Inventor before: Gong Shengzhao |
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Address after: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Patentee after: Guangdong Industry Technical College Patentee after: Zeli Medicine Tech Co., Ltd., Guangzhou Address before: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Patentee before: Guangdong Industry Technical College Patentee before: Guangzhou Ze force Pharmaceutical Co. Ltd. |