CN110075049A - A kind of Chinese medical extract and its preparation method and application - Google Patents
A kind of Chinese medical extract and its preparation method and application Download PDFInfo
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- CN110075049A CN110075049A CN201910492526.9A CN201910492526A CN110075049A CN 110075049 A CN110075049 A CN 110075049A CN 201910492526 A CN201910492526 A CN 201910492526A CN 110075049 A CN110075049 A CN 110075049A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9761—Cupressaceae [Cypress family], e.g. juniper or cypress
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- A61Q7/00—Preparations for affecting hair growth
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The present invention relates to a kind of Chinese medical extract and its preparation method and application, the Chinese medical extract prepares the component that raw material includes following mass percentage: root bark of white mulberry 0.1%-60%, race 0.1%-60%, cacumen biotae 0.1%-60%, Radix Glycyrrhizae 0.1%-60%, Schisandra chinensis 0.1-60%；The preparation method includes the following steps: that (1) pre-processes: the root bark of white mulberry of formula ratio, race, cacumen biotae, Radix Glycyrrhizae and Schisandra chinensis being respectively crushed into powder, obtain mixed-powder after mixing；(2) it extracts: Extraction solvent being added in Xiang Suoshu mixed-powder, impregnate, separate, obtaining concentrate after concentration to get the Chinese medical extract is arrived.The activity of hair and scalp cells can be improved in Chinese medical extract provided by the invention, improves head blood circulation, and secured root of hair prevents hair loss and has hair-growing effects, and has the function of anti-inflammatory, antibacterial, and safety is without side-effects.
Description
Technical field
The present invention relates to daily chemicals fields, and in particular to a kind of Chinese medical extract and its preparation method and application, more particularly to
It is a kind of to have effects that anticreep, Chinese medical extract of hair tonic and its preparation method and application.
Background technique
Hair hair is the accessory organ of skin, has the function of certain defence and keeps body temperature, it is often more important that it
As the second feature of people, there is very strong rhetorical function, its plasticity, selectivity and dicoration, to Head And Face,
Shoulder neck, so that the coordinative role of entire posture seems even more important.Everyone is intended to keep more for a long time as far as possible
Hair amount, it is most important that, avoid alopecia.From 35 years old, apparent alopecia can occur for about 40% male, and 60 years old women
Alopecia incidence is up to 80%.Cause this phenomenon of alopecia most apparent the reason is that aging, aging will lead to hair follicle atrophy, hair
Growth cycle shortens.The factors such as pressure, hormone variation, heredity, malnutrition also result in alopecia.
The hair washing product of Anti-hair loss is irregular on the market at present, really plays the again fewer and fewer of anticreep effect.Medicine
On, the common method of hair growth is exceptionally used and two classes for oral administration.Externally applied drug mainly has minoxidilum, Ciclosporin A etc., but to body
There is certain side effect, drug withdrawal can recur.Medicine for oral administration is mainly antiandrogen preparation, such as Finasteride, cyproterone acetate
Deng curative effect can be improved in oral antiandrogen preparation, but can reduce the level of protona in serum and scalp, so that sexual desire
Decline, while there is teratogenesis, it is impossible to be used in children and the women of child-bearing age.
CN109316427A discloses a kind of loss preventing plant shampoo, including following components: 2 parts of sorbierite, polyoxyethylene
2 parts of polyethylene glycol, 10 parts of ethyl alcohol, 1 part of polyoxyethylene oleate, 4 parts of aloe extract, 1 part of polyglutamic acid, 2 parts of butanediol, coconut palm
5 parts of seed oil fatty diglycollic amide, 1 part of erucic acid, 3 parts of glycerol, 1 part of preservative, 10 parts of triethanolamine, 58 parts of deionized water.
The shampoo further includes ramulus cinnamomi and honeysuckle flower.This shampoo can clean hair scalp, prevent epilation, dredging blood network
Effect, but hair tonic, anticreep effect have it is to be hoisted.
CN109718143A discloses a kind of anticreep shampoo, the substance including following parts by weight: 100 parts of water, amino acid
10-15 parts of foaming agent, 1-5 parts of vitamin B5, -3 parts of vitamin e1, NaCl5-10 parts, 3-8 parts of glycerol, Rosmarinus officinalis extract 5-8
Part, 6-8 parts of hyaluronic acid, 3-6 parts of Sweet Almond Oil, 3-10 parts of Lavender, 1-5 parts of grape seed extract, butter fruit are extracted
1-5 parts of object.The anticreep shampoo that the invention provides, ingredient is natural, and sensitive group is suitble to use, and energy effective protection hair quality is not damaged
Wound nourishes root of hair, keeps hair not easily to fall off, it is seen that the shampoo is only capable of the correct effect for initiating to arrive protection and nourish, can not
Enough to solve the problems, such as alopecia from the root, effect is unobvious.
CN1608609A discloses a kind of external application cosmeceutical and compounding method, especially a kind of fast-acting hair-growing agent and prepares
Method.The fast-acting hair-growing agent is by cortex albiziae, China rose, paris polyphylla, rhizoma atractylodis, Schisandra chinensis, safflower, Rhizoma Chuanxiong, Radix Codonopsis, white
The root of Dahurian angelica, Rhizoma Gastrodiae, radix rehmanniae preparata, Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, rhizoma zingiberis, semen sojae atricolor, camphor, borneol, minoxidilum, which are crushed, is dissolved in ethyl alcohol (75% disinfection
Alcohol) it filters.Cure mainly alopecia areata, whole alopecia, general alopecia, alopecia seborrheica, nervous baldness, hereditary alopecia, alopecia after chemotherapy,
The alopecias venereal disease disease such as premature alopecia, has effects that hair tonic, for various alopecias, seasonal alopecia, postpartum alopecia, comb
Hair etc. is washed off, has effects that strengthen the hair, has effects that black hair for young person with greying hair, gray hair of the middle aged, while there is anti-inflammatory analgetic, smelting to treat
The effect of favus of the scalp dermatitis, dandruff-removing itching-relieve, to preventing dry hair, hair tip bifurcated, break apart fork remarkable efficacy.But the makeup
Side effect may be brought containing ingredients such as minoxidilums in drug, and is easy recurrence after being discontinued.
Therefore, a kind of novel product is urgently developed in this field, can have effects that apparent anticreep, hair tonic, and
Safety is without side-effects.
Summary of the invention
One of the objects of the present invention is to provide a kind of Chinese medical extracts and its preparation method and application, in particular, in that providing
It is a kind of to have effects that anticreep, Chinese medical extract of hair tonic and its preparation method and application, and Chinese medical extract safety is without pair
Effect.
To achieve this purpose, the present invention adopts the following technical scheme:
The present invention provides a kind of Chinese medical extract, and the raw material for preparing of the Chinese medical extract includes following mass percentage
Component: root bark of white mulberry 0.1%-60%, race 0.1%-60%, cacumen biotae 0.1%-60%, Radix Glycyrrhizae 0.1%-60%, Schisandra chinensis
0.1-60%.
The mass percent of the root bark of white mulberry can for 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 8%, 10%,
11%, 12%, 13%, 15%, 18%, 19%, 20%, 22%, 23%, 24%, 25%, 28%, 30%, 31%, 33%,
35%, 36%, 38%, 40%, 42%, 43%, 45%, 46%, 48%, 50%, 51%, 54%, 55%, 57%, 58%,
59% etc..
The mass percent of the race can for 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 8%, 10%,
11%, 12%, 13%, 15%, 18%, 19%, 20%, 22%, 23%, 24%, 25%, 28%, 30%, 31%, 33%,
35%, 36%, 38%, 40%, 42%, 43%, 45%, 46%, 48%, 50%, 51%, 54%, 55%, 57%, 58%,
59% etc..
The mass percent of the cacumen biotae can for 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 8%, 10%,
11%, 12%, 13%, 15%, 18%, 19%, 20%, 22%, 23%, 24%, 25%, 28%, 30%, 31%, 33%,
35%, 36%, 38%, 40%, 42%, 43%, 45%, 46%, 48%, 50%, 51%, 54%, 55%, 57%, 58%,
59% etc..
The mass percent of the Radix Glycyrrhizae can for 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 8%, 10%,
11%, 12%, 13%, 15%, 18%, 19%, 20%, 22%, 23%, 24%, 25%, 28%, 30%, 31%, 33%,
35%, 36%, 38%, 40%, 42%, 43%, 45%, 46%, 48%, 50%, 51%, 54%, 55%, 57%, 58%,
59% etc..
The mass percent of the Schisandra chinensis can for 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 8%, 10%,
11%, 12%, 13%, 15%, 18%, 19%, 20%, 22%, 23%, 24%, 25%, 28%, 30%, 31%, 33%,
35%, 36%, 38%, 40%, 42%, 43%, 45%, 46%, 48%, 50%, 51%, 54%, 55%, 57%, 58%,
59% etc..
Chinese medical extract provided by the invention it is as follows the effect of preparing each ingredient in raw material:
The root bark of white mulberry: it is cold in nature, sweet in flavor, take energy removing heat from lung and relieving asthma, inducing diuresis for removing edema orally, external application can control " hair temples degeneration, send out withered not damp ",
With decompression, anti-inflammatory, antibacterial and other effects.
Race: property pungent-warm is contained gingerol, zingiberene oil isoreactivity ingredient in extract, can be stopped with cold dispelling sweating, resolving sputum
Cough, stomach function regulating, preventing or arresting vomiting control skin edema, Energy benefit taste.
Cacumen biotae: property is bitter, puckery, trembles with fear, and has cooling blood and hemostasis, preventing phlegm from forming and stopping coughing, growing and blacking hair and other effects." grandson true man's food is avoided " note
Carry: hair is not given birth to, and cacumen biotae is dried in the shade, and makees end and sesame oil applies it.
Radix Glycyrrhizae: sweet in flavor, mild-natured, licorice chemical component containing there are many, wherein glycyrrhizic acid has anti-inflammatory, whitening, educates
The effect of hair.
Schisandra chinensis: containing schizandrin, vitamin C etc. in its extract, have astringe the lung to stop cough, nourish arresting seminal emission, antidiarrheal is stopped
The effect of sweat.
This five kinds of Chinese medicines compound by a certain percentage, then extract to obtain Chinese medical extract, according to the principle of monarch, minister and assistant,
It acts synergistically between the active constituent of specific proportion in the Chinese medical extract, the activity of hair and scalp cells can be improved,
Improve head blood circulation, secured root of hair prevents hair loss and has hair-growing effects, and has the function of anti-inflammatory, antibacterial；In meanwhile
Herbal medicine source, mild safety, is not in the adverse reactions such as pruitus, Contact hyper sensitization.
Preferably, the Chinese medical extract prepares the component that raw material includes following mass percentage: root bark of white mulberry 1%-
50%, race 1%-50%, cacumen biotae 1%-50%, Radix Glycyrrhizae 1%-50%, Schisandra chinensis 1-50%.
Formula is advanced optimized, five kinds of components of certain content are selected, realizes better compatibility between active constituent, favorably
In the anticreep and hair-growing effects that further promote Chinese medicine composition.
Preferably, the Chinese medical extract prepares the component that raw material includes following mass percentage: the root bark of white mulberry 30%,
Race 20%, cacumen biotae 20%, Radix Glycyrrhizae 10%, Schisandra chinensis 20%.
Preferably, the Chinese medical extract prepares the component that raw material includes following mass percentage: the root bark of white mulberry 50%,
Race 10%, cacumen biotae 10%, Radix Glycyrrhizae 10%, Schisandra chinensis 20%.
Preferably, the Chinese medical extract prepares the component that raw material includes following mass percentage: the root bark of white mulberry 5%,
Race 10%, cacumen biotae 40%, Radix Glycyrrhizae 15%, Schisandra chinensis 30%.
Preferably, the Chinese medical extract prepares the component that raw material includes following mass percentage: the root bark of white mulberry 15%,
Race 25%, cacumen biotae 25%, Radix Glycyrrhizae 25%, Schisandra chinensis 10%.
Preferably, the Chinese medical extract prepares the component that raw material includes following mass percentage: the root bark of white mulberry 5%,
Race 30%, cacumen biotae 20%, Radix Glycyrrhizae 30%, Schisandra chinensis 15%.
The second object of the present invention is to provide a kind of preparation method of Chinese medical extract described in the first purpose, feature
It is, the preparation method includes the following steps:
(1) it pre-processes: the root bark of white mulberry of formula ratio, race, cacumen biotae, Radix Glycyrrhizae and Schisandra chinensis is respectively crushed into powder, mix
Mixed-powder is obtained after conjunction；
(2) extract: being added Extraction solvent in Xiang Suoshu mixed-powder, impregnate, separation, obtain after concentration concentrate to get
To the Chinese medical extract.
Preferably, the granularity of the powder is 100-500 mesh.
Preferably, in step (2), the Extraction solvent includes water and/or ethyl alcohol.
Preferably, in step (2), the mass ratio of the Extraction solvent and the mixed-powder is 1:1-40:1, such as 2:
1、3:1、4:1、5:1、8:1、10:1、12:1、15:1、16:1、18:1、19:1、20:1、22:1、25:1、26:1、28:1、30:
1,31:1,32:1,33:1,34:1,35:1,36:1,37:1,38:1,39:1 etc..
Preferably, in step (2), time of the immersion is 1-5h, for example, 1.1h, 1.2h, 1.3h, 1.5h, 1.6h,
1.8h、2.0h、2.2h、2.3h、2.5h、2.7h、2.8h、2.9h、3.0h、3.2h、3.5h、3.8h、4.0h、4.1h、4.2h、
4.3h, 4.5h, 4.7h, 4.8h, 4.9h etc..
Preferably, in step (2), described be immersed in water-bath is carried out, and the temperature of the preferably described water-bath is 40-90
DEG C, for example, 41 DEG C, 42 DEG C, 43 DEG C, 44 DEG C, 45 DEG C, 46 DEG C, 48 DEG C, 50 DEG C, 52 DEG C, 55 DEG C, 56 DEG C, 57 DEG C, 58 DEG C, 59 DEG C,
60℃、62℃、63℃、64℃、65℃、67℃、68℃、69℃、70℃、72℃、75℃、78℃、80℃、82℃、85℃、86
DEG C, 87 DEG C, 88 DEG C, 89 DEG C etc..
Preferably, in step (2), the isolated method includes centrifuge separation.
Preferably, step (3) are carried out after step (2): concentrate obtained in step (2) is purified, then into
Row concentration and filtering, obtain the Chinese medical extract.
Preferably, in step (3), the method for the purifying includes being purified using macroreticular resin.
Preferably, the granularity of the macroreticular resin is 20-50 mesh.
Preferably, the macroreticular resin includes any one in AB-8, D1300 and D101 or at least two combinations.
Preferably, in step (2) and step (3), the method for the concentration includes rotary evaporation.
Preferably, the preparation method specifically comprises the following steps:
(1) pre-process: the root bark of white mulberry of formula ratio, race, cacumen biotae, Radix Glycyrrhizae and Schisandra chinensis, which are respectively crushed into granularity, is
100-500 mesh powder, obtains mixed-powder after mixing；
(2) extract: in Xiang Suoshu mixed-powder according to the mass ratio of Extraction solvent and mixed-powder be 1:1-40:1 be added
Extraction solvent impregnates 1-5 hours in 40-90 DEG C of water-bath, obtains concentrate after centrifuge separation, rotary evaporation；
(3) it purifies: the concentrate being purified using the macroreticular resin that granularity is 20-50 mesh, then carries out rotation steaming
Hair and filtering, obtain the Chinese medical extract.
The third object of the present invention is that providing one kind washes shield product, described to wash in shield product containing described in the first purpose
Chinese medical extract.
Preferably, it is 0.1%-80% that the Chinese medical extract, which accounts for the mass percent for washing shield product, such as
0.2%, 0.5%, 0.8%, 1.0%, 2%, 5%, 7%, 9%, 10%, 15%, 20%, 25%, 30%, 35%, 40%,
45%, 50%, 55%, 60%, 65%, 70%, 75%, 78%, 79% etc., preferably 1%-50%, further preferred 5%-
40%.
Preferably, the shield product of washing includes shampoo, take care of hair spraying, washing-free hair Essence, hair conditioner or hair film.
Compared with the existing technology, the invention has the following advantages:
The activity of hair and scalp cells can be improved in Chinese medical extract provided by the invention, improves head blood circulation,
Secured root of hair prevents hair loss and has hair-growing effects, and has the function of anti-inflammatory, antibacterial；Meanwhile resources of Chinese medicinal herb, it is mild to pacify
It entirely, is not in the adverse reactions such as pruitus, Contact hyper sensitization.
Specific embodiment
The technical scheme of the invention is further explained by means of specific implementation.Those skilled in the art should be bright
, the described embodiments are merely helpful in understanding the present invention, should not be regarded as a specific limitation of the invention.
The preparation of 1 Chinese medical extract of embodiment (1)
Chinese medical extract provided in this embodiment prepares the component that raw material includes following mass percentage: the root bark of white mulberry
30%, race 20%, cacumen biotae 20%, Radix Glycyrrhizae 10%, Schisandra chinensis 20%.
It is specific the preparation method is as follows:
(1) pre-process: the root bark of white mulberry of formula ratio, race, cacumen biotae, Radix Glycyrrhizae and Schisandra chinensis, which are respectively crushed into granularity, is
200 mesh powder, obtain mixed-powder after mixing；
(2) it extracts: water (mass ratio of water and mixed-powder is 30:1) being added in Xiang Suoshu mixed-powder, in 80 DEG C of water
It is impregnated 4 hours in bath, obtains concentrate after centrifuge separation, rotary evaporation；
(3) it purifies: the concentrate being purified using AB-8 macroreticular resin, then carries out rotary evaporation and filtering, is obtained
To the Chinese medical extract.
The preparation of 2 Chinese medical extract of embodiment (2)
Chinese medical extract provided in this embodiment prepares the component that raw material includes following mass percentage: the root bark of white mulberry
50%, race 10%, cacumen biotae 10%, Radix Glycyrrhizae 10%, Schisandra chinensis 20%.
It is specific the preparation method is as follows:
(1) pre-process: the root bark of white mulberry of formula ratio, race, cacumen biotae, Radix Glycyrrhizae and Schisandra chinensis, which are respectively crushed into granularity, is
200 mesh powder, obtain mixed-powder after mixing；
(2) it extracts: water (mass ratio of water and mixed-powder is 10:1) being added in Xiang Suoshu mixed-powder, in 80 DEG C of water
It is impregnated 4 hours in bath, obtains concentrate after centrifuge separation, rotary evaporation；
(3) it purifies: the concentrate being purified using AB-8 macroreticular resin, then carries out rotary evaporation and filtering, is obtained
To the Chinese medical extract.
The preparation of 3 Chinese medical extract of embodiment (3)
Chinese medical extract provided in this embodiment prepares the component that raw material includes following mass percentage: the root bark of white mulberry
5%, race 10%, cacumen biotae 40%, Radix Glycyrrhizae 15%, Schisandra chinensis 30%.
It is specific the preparation method is as follows:
(1) pre-process: the root bark of white mulberry of formula ratio, race, cacumen biotae, Radix Glycyrrhizae and Schisandra chinensis, which are respectively crushed into granularity, is
300 mesh powder, obtain mixed-powder after mixing；
(2) it extracts: water (mass ratio of water and mixed-powder is 20:1) being added in Xiang Suoshu mixed-powder, in 45 DEG C of water
It is impregnated 5 hours in bath, obtains concentrate after centrifuge separation, rotary evaporation；
(3) it purifies: the concentrate being purified using D101 macroreticular resin, then carries out rotary evaporation and filtering, is obtained
To the Chinese medical extract.
The preparation of 4 Chinese medical extract of embodiment (4)
Chinese medical extract provided in this embodiment prepares the component that raw material includes following mass percentage: the root bark of white mulberry
15%, race 25%, cacumen biotae 25%, Radix Glycyrrhizae 25%, Schisandra chinensis 10%.
It is specific the preparation method is as follows:
(1) pre-process: the root bark of white mulberry of formula ratio, race, cacumen biotae, Radix Glycyrrhizae and Schisandra chinensis, which are respectively crushed into granularity, is
200 mesh powder, obtain mixed-powder after mixing；
(2) it extracts: water (mass ratio of water and mixed-powder is 30:1) being added in Xiang Suoshu mixed-powder, in 50 DEG C of water
It is impregnated 5 hours in bath, obtains concentrate after centrifuge separation, rotary evaporation；
(3) it purifies: the concentrate being purified using AB-8 macroreticular resin, then carries out rotary evaporation and filtering, is obtained
To the Chinese medical extract.
The preparation of 5 Chinese medical extract of embodiment (5)
Chinese medical extract provided in this embodiment prepares the component that raw material includes following mass percentage: the root bark of white mulberry
5%, race 30%, cacumen biotae 20%, Radix Glycyrrhizae 30%, Schisandra chinensis 15%.
It is specific the preparation method is as follows:
(1) pre-process: the root bark of white mulberry of formula ratio, race, cacumen biotae, Radix Glycyrrhizae and Schisandra chinensis, which are respectively crushed into granularity, is
150 mesh powder, obtain mixed-powder after mixing；
(2) it extracts: water (mass ratio of water and mixed-powder is 40:1) being added in Xiang Suoshu mixed-powder, in 85 DEG C of water
It is impregnated 2 hours in bath, obtains concentrate after centrifuge separation, rotary evaporation；
(3) it purifies: the concentrate being purified using D1300 macroreticular resin, then carries out rotary evaporation and filtering, is obtained
To the Chinese medical extract.
The preparation of 6 Chinese medical extract of embodiment (6)
The difference from embodiment 1 is that Chinese medicine extract prepares the component that raw material includes following mass percentage:
The root bark of white mulberry 50%, race 1%, cacumen biotae 1%, Radix Glycyrrhizae 1%, Schisandra chinensis 47%
The preparation of 7 Chinese medical extract of embodiment (7)
The difference from embodiment 1 is that Chinese medicine extract prepares the component that raw material includes following mass percentage:
The root bark of white mulberry 1%, race 50%, cacumen biotae 32%, Radix Glycyrrhizae 16%, Schisandra chinensis 1%.
The preparation of 8 Chinese medical extract of embodiment (8)
The difference from embodiment 1 is that Chinese medicine extract prepares the component that raw material includes following mass percentage:
The root bark of white mulberry 22%, race 8%, cacumen biotae 50%, Radix Glycyrrhizae 11%, Schisandra chinensis 9%.
The preparation of 9 Chinese medical extract of embodiment (9)
The difference from embodiment 1 is that Chinese medicine extract prepares the component that raw material includes following mass percentage:
The root bark of white mulberry 20%, race 10%, cacumen biotae 10%, Radix Glycyrrhizae 50%, Schisandra chinensis 10%.
The preparation of 10 Chinese medical extract of embodiment (10)
The difference from embodiment 1 is that Chinese medicine extract prepares the component that raw material includes following mass percentage:
The root bark of white mulberry 20%, race 10%, cacumen biotae 10%, Radix Glycyrrhizae 10%, Schisandra chinensis 50%.
The preparation of 11 Chinese medical extract of embodiment (11)
The difference from embodiment 1 is that Chinese medicine extract prepares the component that raw material includes following mass percentage:
The root bark of white mulberry 60%, race 0.1%, cacumen biotae 0.1%, Radix Glycyrrhizae 0.1%, Schisandra chinensis 39.7%.
The preparation of 12 Chinese medical extract of embodiment (12)
The difference from embodiment 1 is that Chinese medicine extract prepares the component that raw material includes following mass percentage:
The root bark of white mulberry 0.1%, race 60%, cacumen biotae 16%, Radix Glycyrrhizae 7.9%, Schisandra chinensis 16%.
The preparation of 13 Chinese medical extract of embodiment (13)
The difference from embodiment 1 is that Chinese medicine extract prepares the component that raw material includes following mass percentage:
The root bark of white mulberry 19.9%, race 10%, cacumen biotae 60%, Radix Glycyrrhizae 10%, Schisandra chinensis 0.1%.
The preparation of 14 Chinese medical extract of embodiment (14)
The difference from embodiment 1 is that Chinese medicine extract prepares the component that raw material includes following mass percentage:
The root bark of white mulberry 10%, race 10%, cacumen biotae 10%, Radix Glycyrrhizae 60%, Schisandra chinensis 10%.
The preparation of 15 Chinese medical extract of embodiment (15)
The difference from embodiment 1 is that Chinese medicine extract prepares the component that raw material includes following mass percentage:
The root bark of white mulberry 15%, race 10%, cacumen biotae 10%, Radix Glycyrrhizae 5%, Schisandra chinensis 60%.
The preparation of 16 Chinese medical extract of embodiment (16)
The difference from embodiment 1 is that it is specific the preparation method is as follows:
(1) pre-process: the root bark of white mulberry of formula ratio, race, cacumen biotae, Radix Glycyrrhizae and Schisandra chinensis, which are respectively crushed into granularity, is
100 mesh powder, obtain mixed-powder after mixing；
(2) it extracts: ethyl alcohol (mass ratio of ethyl alcohol and mixed-powder is 1:1) being added in Xiang Suoshu mixed-powder, at 40 DEG C
Water-bath in impregnate 5 hours, centrifuge separation obtains concentrate after rotary evaporation；
(3) it purifies: the concentrate being purified using D1300 macroreticular resin, then carries out rotary evaporation and filtering, is obtained
To the Chinese medical extract.
The preparation of 17 Chinese medical extract of embodiment (17)
The difference from embodiment 1 is that it is specific the preparation method is as follows:
(1) pre-process: the root bark of white mulberry of formula ratio, race, cacumen biotae, Radix Glycyrrhizae and Schisandra chinensis, which are respectively crushed into granularity, is
500 mesh powder, obtain mixed-powder after mixing；
(2) extract: in Xiang Suoshu mixed-powder be added mass ratio be 10:7 water/alcohol mixture (water/alcohol mixture with
The mass ratio of mixed-powder is 30:1), it impregnates 1 hour in 90 DEG C of water-bath, is concentrated after centrifuge separation, rotary evaporation
Liquid；
(3) it purifies: the concentrate being purified using the macroreticular resin of AB-8, then carries out rotary evaporation and filtering,
Obtain the Chinese medical extract.
The preparation of 1 Chinese medical extract of comparative example (D1)
The difference from embodiment 1 is that Chinese medical extract prepares the component that raw material includes following mass percentage: mulberry
White skin 100%.
The preparation of 2 Chinese medical extract of comparative example (D2)
The difference from embodiment 1 is that Chinese medical extract prepares the component that raw material includes following mass percentage: ginger
Root 100%.
The preparation of 3 Chinese medical extract of comparative example (D3)
The difference from embodiment 1 is that Chinese medical extract prepares the component that raw material includes following mass percentage: side
CedarLeaves 100%.
The preparation of 4 Chinese medical extract of comparative example (D4)
The difference from embodiment 1 is that Chinese medical extract prepares the component that raw material includes following mass percentage: sweet
Grass 100%.
The preparation of 5 Chinese medical extract of comparative example (D5)
The difference from embodiment 1 is that Chinese medical extract prepares the component that raw material includes following mass percentage: five
Taste 100%.
The preparation of 6 Chinese medical extract of comparative example (D6)
The difference from embodiment 1 is that Chinese medical extract prepares the component that raw material includes following mass percentage: ginger
Root 28.6%, cacumen biotae 28.6%, Radix Glycyrrhizae 14.2%, Schisandra chinensis 28.6%.
The preparation of 7 Chinese medical extract of comparative example (D7)
The difference from embodiment 1 is that Chinese medical extract prepares the component that raw material includes following mass percentage: mulberry
White skin 37.5%, cacumen biotae 25%, Radix Glycyrrhizae 12.5%, Schisandra chinensis 25%.
The preparation of 8 Chinese medical extract of comparative example (D8)
The difference from embodiment 1 is that Chinese medical extract prepares the component that raw material includes following mass percentage: mulberry
White skin 37.5%, race 25%, Radix Glycyrrhizae 12.5%, Schisandra chinensis 25%.
The preparation of 9 Chinese medical extract of comparative example (D9)
The difference from embodiment 1 is that Chinese medical extract prepares the component that raw material includes following mass percentage: mulberry
White skin 30%, race 20%, cacumen biotae 20%, Schisandra chinensis 20%.
The preparation of 10 Chinese medical extract of comparative example (D10)
The difference from embodiment 1 is that Chinese medical extract prepares the component that raw material includes following mass percentage: mulberry
White skin 33.4%, race 22.2%, cacumen biotae 22.2%, Radix Glycyrrhizae 22.2%.
Application examples 1
The application example provides a kind of anticreep shampoo, includes following component according to mass percent:
The anticreep shampoo the preparation method is as follows:
(1) by water, laureth sodium sulfovinate, laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, polyquaternary amine
Salt -10, sodium citrate, citric acid, EDETATE SODIUM, sodium benzoate, glycol distearate are put into container, are heated with stirring to
85 DEG C, stirring and dissolving obtains mixed liquor A to transparent；
(2) mixed liquor A is cooled to 45 DEG C, Chinese medical extract (1), essence, Phenoxyethanol, moisturizing, mixing is added.
Application examples 2
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (2) of quality.
Application examples 3
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (3) of quality.
Application examples 4
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (4) of quality.
Application examples 5
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (5) of quality.
Application examples 6
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (6) of quality.
Application examples 7
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (7) of quality.
Application examples 8
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (8) of quality.
Application examples 9
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (9) of quality.
Application examples 10
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (10) of quality.
Application examples 11
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (11) of quality.
Application examples 12
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (12) of quality.
Application examples 13
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (13) of quality.
Application examples 14
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (14) of quality.
Application examples 15
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (15) of quality.
Application examples 16
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (16) of quality.
Application examples 17
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (17) of quality.
Application examples 18
The application example provides a kind of anticreep shampoo, includes following component according to mass percent:
The preparation method is as follows:
(1) by water, laureth sulfuric ester ammonium, laurel alcohol sulfuric ester ammonium, Sodium Lauroamphoacetate, melon rubber hydroxyl
Hydroxypropyltrimonium chloride, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, EDETATE SODIUM, ethylene glycol two
Stearate is put into container, and homogeneous is heated with stirring to 85 DEG C, and stirring and dissolving with sodium hydroxide tune pH to 6.5, is obtained to transparent
To mixed liquor A；
(2) mixed liquor A is cooled to 45 DEG C, Chinese medical extract (1), essence, Kathon CG, moisturizing, with citric acid tune pH is added
To 6.0, mixing.
Application examples 19
The application example provides a kind of anticreep shampoo, includes following component according to mass percent:
The preparation method is as follows:
(1) by water, laureth sodium sulfovinate, laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, polyquaternary amine
Salt -10, sodium citrate, citric acid, EDETATE SODIUM, sodium benzoate, glycol distearate are put into container, are heated with stirring to
85 DEG C, stirring and dissolving obtains mixed liquor A to transparent；
(2) mixed liquor A is cooled to 45 DEG C, Chinese medical extract (3), essence, Phenoxyethanol, moisturizing, mixing is added.
Application examples 20
The application example provides a kind of anticreep shampoo, includes following component according to mass percent:
The preparation method is as follows:
(1) by water, sodium lauroyl sarcosine, Sodium Lauroamphoacetate, Cocoamidopropyl betaine, polyquaternary amine
Salt -10, sodium citrate, citric acid, EDETATE SODIUM, sodium benzoate, glycerol monolaurate are put into container, are heated with stirring to 85
DEG C, stirring and dissolving obtains mixed liquor A to transparent；
(2) mixed liquor A is cooled to 45 DEG C, Chinese medical extract (5), essence, Phenoxyethanol, moisturizing, mixing is added.
Application examples 21
The application example provides a kind of disposable anticreep Essence, includes following component according to mass percent:
Wherein acrylic acid (ester) analog copolymer is specially acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymeric
Object.
The preparation method is as follows:
(1) acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer is slowly sprinkled into cold deionized water,
Complete swelling, homogeneous are heated to 80 DEG C, and niacinamide is added, sufficiently dissolves；
(2) 45 DEG C are cooled to, Chinese medical extract (4), glycerol, ethyl alcohol, Phenoxyethanol, essence are sequentially added；
(3) pH value is adjusted to 5.5 with sodium hydroxide solution, stir.
Compare application examples 1
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (D1) of quality.
Compare application examples 2
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (D2) of quality.
Compare application examples 3
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (D3) of quality.
Compare application examples 4
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (D4) of quality.
Compare application examples 5
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (D5) of quality.
Compare application examples 6
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (D6) of quality.
Compare application examples 7
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (D7) of quality.
Compare application examples 8
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (D8) of quality.
Compare application examples 9
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (D9) of quality.
Compare application examples 10
Difference with application examples 1 is, Chinese medical extract (1) is replaced with etc. to the Chinese medical extract (D10) of quality.
Compare application examples 11
Difference with application examples 1 is, does not add Chinese medical extract (1), is replaced with water.
Compare application examples 12
Difference with application examples 21 is, does not add Chinese medical extract (4), is replaced with water.
1 anticreep effect assessment of test example
1650 people of clinic case for being diagnosed as androgenetic alopecia is randomly selected, and stochastic averagina is divided into 33 groups, every group 50
People.1 to 33 group uses the anticreep shampoo of application examples 1-20, the anticreep shampoo for comparing application examples 1-11, application examples 21 respectively
Disposable anticreep Essence, compare application examples 12 disposable anticreep Essence.
The application method of shampoo is as follows:
After patient sufficiently soaks hair, is wiped with towel to half-dried, take appropriate shampoo to be applied on head, homogeneously kneaded head
It skin 5 minutes, stops 5 minutes, then with warm water cleaning.It uses once, and racket head portion photo, is used continuously three months daily.
Other shampoos must not be used by using during this product, avoid impact effect.
The application method of Essence is as follows:
Essence is applied to the place of hair amount rareness by patient, is massaged 10 minutes, until respectively making sooner or later daily to all absorbing
With primary, and racket head portion photo, it is used continuously three months.
Evaluation method: expert group evaluates the hair amount of patient, and be divided into healing (hair amount is basic by comparison photo
Be restored to normal condition), effectively (hair amount increased), invalid (hair amount is unchanged) three grades, and record in every group of personnel
The number of three kinds of grades calculates the percentage of every group of total number of persons shared by each grade number, obtains cure rate, effective percentage and invalid
Rate.Specific evaluation result is as shown in table 1.
Table 1
As shown in Table 1, by trimestral experiment, the cure rate of application examples group and efficient obviously ratio comparison application examples group
Much higher, this illustrates five kinds of Chinese medicines such as the root bark of white mulberry of the invention, race, cacumen biotae, Radix Glycyrrhizae, Schisandra chinensis according to specific proportion group
The anticreep effect being combined is substantially better than and a kind of Chinese medicine is used alone, only uses wherein four kinds of Chinese medicines or without using Chinese medicine,
Chinese medical extract of the invention can effectively solve the problem that alopecia problem, and long-time service can be such that hair amount obviously increases, meanwhile, it is natural next
Source, it is without side-effects.
By comparing application examples 1, the data of 6-15 it is found that the composition of raw materials when the Chinese medical extract meets the root bark of white mulberry
(application examples 1,6- when 1%-50%, race 1%-50%, cacumen biotae 1%-50%, Radix Glycyrrhizae 1%-50%, Schisandra chinensis 1-50%
10), cure rate is higher, i.e., the described Chinese medical extract has effects that more preferably anticreep, hair tonic.
2 erythrocyte hemolysis of test example tests (RBC test)
Erythrocyte hemolysis experiment is one of lagophthalmos irritant experiment (Draize test) alternative, and basic principle is logical
It crosses measurement hemoglobin the amount of dissolution and denaturation degrees carrys out damage of the evaluating chemical product to ocular tissue's cell.In the world mainly by RBC
The eye irritation for evaluating the chemicals such as cosmetics and raw material is tested to study.
The product of application examples 1-21 is subjected to erythrocyte hemolysis experiment, this experiment is according to European alternative authentication center
(ECVAM) RBC experimental test procedures and grade scale.[ECVAM.ECVAM DB-ALM:INVITOX Protoco,Red
blood cells test system.INVITOX No.37.Ispra.Italy:ECVAM,1994.]
2 ECVAM cosmetic product RBC of table tests irritation grade scale
| L/D | Classification |
| ﹥ 100 | It is nonirritant |
| 10 L/D≤100 ﹤ | Microstimulation |
| 1 L/D≤10 ﹤ | Slight stimulation |
| 0.1 L/D≤1 ﹤ | Moderate irritation |
| L/D≤0.1 | Severe irritation |
Wherein, L/D is the ratio of HC50 and DI, and HC50 is half erythrocyte hemolysis concentration, and DI is that hemoglobin denaturation refers to
Number.
Each product erythrocyte hemolysis experimental result of table 3
As shown in Table 3, it is in nonirritant for obtaining application examples 1-21 by the ratio L/D of HC50 and DI.Therefore, of the invention
Chinese medical extract apply wash shield product in it is safe and non-stimulating, scalp adverse reaction will not be caused.
Method detailed of the invention that the present invention is explained by the above embodiments, but the invention is not limited to it is above-mentioned in detail
Method, that is, do not mean that the invention must rely on the above detailed methods to implement.Person of ordinary skill in the field should
It is illustrated, any improvement in the present invention, addition, the concrete mode of equivalence replacement and auxiliary element to each raw material of product of the present invention
Selection etc., all of which fall within the scope of protection and disclosure of the present invention.
Claims (10)
1. a kind of Chinese medical extract, which is characterized in that the raw material for preparing of the Chinese medical extract includes following mass percentage
Component: root bark of white mulberry 0.1%-60%, race 0.1%-60%, cacumen biotae 0.1%-60%, Radix Glycyrrhizae 0.1%-60%, Schisandra chinensis
0.1-60%.
2. Chinese medical extract according to claim 1, which is characterized in that the Chinese medical extract prepare raw material include with
The component of lower mass percentage: root bark of white mulberry 1%-50%, race 1%-50%, cacumen biotae 1%-50%, Radix Glycyrrhizae 1%-50%,
Schisandra chinensis 1-50%.
3. Chinese medical extract according to claim 1 or 2, which is characterized in that the Chinese medical extract prepares raw material packet
Include the component of following mass percentage: the root bark of white mulberry 30%, race 20%, cacumen biotae 20%, Radix Glycyrrhizae 10%, Schisandra chinensis 20%.
4. Chinese medical extract according to claim 1 or 2, which is characterized in that the Chinese medical extract prepares raw material packet
Include the component of following mass percentage: the root bark of white mulberry 50%, race 10%, cacumen biotae 10%, Radix Glycyrrhizae 10%, Schisandra chinensis 20%.
5. Chinese medical extract according to claim 1 or 2, which is characterized in that the Chinese medical extract prepares raw material packet
Include the component of following mass percentage: the root bark of white mulberry 5%, race 10%, cacumen biotae 40%, Radix Glycyrrhizae 15%, Schisandra chinensis 30%.
6. Chinese medical extract according to claim 1 or 2, which is characterized in that the Chinese medical extract prepares raw material packet
Include the component of following mass percentage: the root bark of white mulberry 15%, race 25%, cacumen biotae 25%, Radix Glycyrrhizae 25%, Schisandra chinensis 10%.
7. Chinese medical extract according to claim 1 or 2, which is characterized in that the Chinese medical extract prepares raw material packet
Include the component of following mass percentage: the root bark of white mulberry 5%, race 30%, cacumen biotae 20%, Radix Glycyrrhizae 30%, Schisandra chinensis 15%.
8. a kind of preparation method of Chinese medical extract described in any one of -7 according to claim 1, which is characterized in that the system
Preparation Method includes the following steps:
(1) it pre-processes: the root bark of white mulberry of formula ratio, race, cacumen biotae, Radix Glycyrrhizae and Schisandra chinensis being respectively crushed into powder, after mixing
Obtain mixed-powder；
(2) it extracts: being added Extraction solvent in Xiang Suoshu mixed-powder, impregnate, separation, obtain concentrate after concentration to get to institute
State Chinese medical extract.
9. preparation method according to claim 8, which is characterized in that in step (1), the granularity of the powder is 100-
500 mesh；
Preferably, in step (2), the Extraction solvent includes water and/or ethyl alcohol；
Preferably, in step (2), the mass ratio of the Extraction solvent and the mixed-powder is 1:1-40:1；
Preferably, in step (2), the time of the immersion is 1-5h；
Preferably, in step (2), described be immersed in water-bath is carried out, and the temperature of the preferably described water-bath is 40-90 DEG C；
Preferably, in step (2), the isolated method includes centrifuge separation；
Preferably, step (3) are carried out after step (2): concentrate obtained in step (2) is purified, then is carried out dense
Contracting and filtering, obtain the Chinese medical extract；
Preferably, in step (3), the method for the purifying includes being purified using macroreticular resin；
Preferably, the granularity of the macroreticular resin is 20-50 mesh；
Preferably, the macroreticular resin includes any one in AB-8, D1300 and D101 or at least two combinations；
Preferably, in step (2) and step (3), the method for the concentration includes rotary evaporation；
Preferably, the preparation method specifically comprises the following steps:
(1) pre-process: it is 100- that the root bark of white mulberry of formula ratio, race, cacumen biotae, Radix Glycyrrhizae and Schisandra chinensis, which are respectively crushed into granularity,
500 mesh powder, obtain mixed-powder after mixing；
(2) it extracts: being added and extract for 1:1-40:1 according to the mass ratio of Extraction solvent and mixed-powder in Xiang Suoshu mixed-powder
Solvent impregnates 1-5 hours in 40-90 DEG C of water-bath, obtains concentrate after centrifuge separation, rotary evaporation；
(3) purify: by the concentrate using granularity be 20-50 mesh macroreticular resin purify, then carry out rotary evaporation and
Filtering, obtains the Chinese medical extract.
10. one kind washes shield product, which is characterized in that described wash in shield product is contained in of any of claims 1-7
Medicament extract；
Preferably, it is 0.1%-80%, preferably 1%-50% that the Chinese medical extract, which accounts for the mass percent for washing shield product,
Further preferred 5%-40%；
Preferably, the shield product of washing includes shampoo, take care of hair spraying, washing-free hair Essence, hair conditioner or hair film.
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Cited By (3)
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| CN111329981A (en) * | 2020-02-25 | 2020-06-26 | 澳宝化妆品（惠州）有限公司 | Antibacterial, anti-inflammatory and blood circulation-promoting microcapsule Chinese herbal medicine composition and preparation method thereof |
| CN114848554A (en) * | 2022-05-24 | 2022-08-05 | 品高生物科技(广州)有限公司 | Plant compound for preventing hair loss and growing hair and preparation method thereof |
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| CN114848554B (en) * | 2022-05-24 | 2024-01-23 | 品高生物科技(广州)有限公司 | Plant compound capable of preventing hair loss and growing hair and preparation method thereof |
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| CN110075049B (en) | 2022-02-25 |
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Address after: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |
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