CN108096174A - A kind of compound plant extract with hair care anti-off effect and preparation method and application - Google Patents
A kind of compound plant extract with hair care anti-off effect and preparation method and application Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention discloses a kind of compound plant extract with hair care anti-off effect and preparation method and applications.The compound plant extract is prepared by following Chinese medicine：Eclipta, Selaginella tamariscina, Honeysuckle flower, HERBA PORTULACAE, the raw tuber of stemona, caulis lonicerae, Radix Polygoni Multiflori, raw Radix Astragali, the bark of ash, frosted mulberry leaf, Radix Angelicae Sinensis, terminalia flesh, big Radix Rehmanniae, Fructus Mume, rhizoma zingiberis, lucid asparagus, radix salviae miltiorrhizae, Chinese gall, granatum.The present invention is first passed through carries out decocting extraction to foregoing Chinese medicine, and obtained extract is extracted with ethyl alcohol, is concentrated, is obtained compound extract.The compound extract have the beneficial blood of promoting blood circulation, tonify the liver and kidney, promoting spleen yang and securing the exterior, activating qi and collateral, dandruff-removing itching-relieve, clearing heat and detoxicating, convergence anticreep the effect of, available for preparing anti-drop liquid shampoo of taking care of hair.
Description
Technical field
The present invention relates to daily cosmetics technical field, more particularly to a kind of compound plant with hair care anti-off effect carries
Take object and preparation method and application.
Background technology
Hair is a part for tissue, is pushed to skin surface and grows after the from the beginning intracapsular cell division of fur
Fibr tissue, be a kind of hard cutin formed by cytothesis.Hair is made of root of hair and dry two parts, and root of hair exists
Scalp by hair follicle in the following, protected；Hair follicle is a narrow pipeline, is that the epidermis of skin is formed, and is deep into corium
Among, each piece hair of hair follicle growth, the recess of the bottommost of hair follicle is papilla, papilla and connective tissue sheath, is made a living
Hair in length provides nutrition and oxygen.If papilla is destroyed or degenerates, hair just stops growing and gradually comes off.Hair breast
The ball top that somatoblast is formed there are many on head, ball top are the originator of hair, and episphere has chromatophore；In skin corium
In, have that deep sebaceous glands, its main function are secretion greases together with hair follicle, moisten hair, and can be according to its secretion
It is how many to determine the attribute of hair (neutrality, oiliness, dryness).The hair shaft of hair can be divided into epidermis, cortical layer, medullary substance layer three
Layer.A kind of scale substance that epidermis is made of horn cell；Cortical layer is dry most heavy part, controls hair
Moisture determines its hair toughness, elasticity and intensity；Medullary substance layer is dry central part, is cortex cell tissue with the presence of pigment
It is surrounded.
There are many alopecia reason, still not fully aware of so far.Different types of alopecia is as caused by different pathogenic factors
, it is summed up, predominantly the following aspects：(1) hair follicle, ball top portion and hair physiological function are low, and fat secretion surplus is led
It causes to generate alopecia seborrheica or bacterial growth is triggered to generate alopecia furfuracea disease；(2) local blood caused by scalp anxiety
Dyshaemia causes the flow of tip capillary of hair follicle, papilla to reduce, and the food materials of papilla and hair matricyte supply
Should be insufficient, the growth of hair is made exception occur；(3) inherent cause：It is unbalance by male sex hormone especially to male in dominant inheritance
Influence causes alopecia.(4) early bald, alopecia areata：Early bald also known as male pattern alopecia is commonly called as " doctor's head ", and the gradual alopecia of overhead is
Feature is more common in the male being engaged in mental work；Alopecia areata, alopecia areata are commonly called as " alopecia areata ", are a kind of limitation plaque-like alopecias, performance
Occur circular or oval plaque-like alopecia, more no conscious symptons suddenly for head；(5) pathologic alopecia：Mainly due to virus,
The communicable diseases such as bacterium, high fever and Liver and kidney function decline, alopecia caused by Cancerous disease；(6) alopecia traumatica：Physical damage
Wound such as mechanical damage, radioactivity are according to treatment damage, deep burn alopecia, chemical lesion such as acid-base property, agent for permanent hair waving, hair dye etc.
Injure alopecia；(7) spirituality baldness：Nervous, irritated, anxiety is in for a long time for the excessively caused alopecia of stress, such as brain
Alopecia caused by state；(8) dystrophic alopecia：For nutrient balance imbalance or fat metabolic disturbance, especially protein and iron
Supply deficiency, caused by alopecia generalisata：1. salt alopecia：Epilation caused by salt is excessive；2. sugar alopecia：
Alopecia caused by sugar excess；3. hypervitaminosis alopecia：Excess ingestion vitamin makes epithelial cell nuclear fission increase and angling
It is incomplete；(9) medicine type alopecia：Using some drugs alopecia as caused by antitumor drug, anti-tubercular drug, antiepileptic；(10) season
Section, Environmental alopecia：Time of the year when autumn changes into winter weather converts, and air conditioner surroundings hot and cold alternation easily causes alopecia.
Numerous due to alopecia, depilation phenomenon grows in intensity, and has been in the gesture of sprawling, and rejuvenation increasingly.Someone unites
Meter in Chinese only male pattern baldness total number of persons just more than 1.5 hundred million, shows wherein alopecia had just occurred before 25 years old in 60% male
As, and the ratio of the alopecia then higher before 30 years old.Therefore hair care anticreep has become the problem of World Focusing.At present, in the market
Although there are many product for taking care of hair and preventing alopecia, such as containing minoxidil, Finasteride hormone product, and have certain bright
Effective fruit, but long-time service easily causes the serious poison such as hormonal readiness imbalance, endocrine disturbance or even generation functional disorder secondary anti-
It should, it is clear that lose more than gain；It says again, these anti-product-stripping mechanisms of hair care for containing drug ingedient belong to medicinal scope, it is impossible in daily use chemicals
Distribution channel.In some hair cares and the product of prevention alopecia currently on the market, although also there are many can be in daily use chemicals channel flow
The logical shampoo prepared by natural herbs extraction, but mostly studied and prevented in terms of a certain two, very
It is few to go to send out from numerous reasons of alopecia, not only using the dialectical advantage of traditional Chinese medicine theory, but also modern medicine is applied to adjust in all directions
Manage the physiological function of scalp, daily use chemicals distribution channel needs must be met by not only having studied product prescription, but also study the superior efficacy of product without
Toxic side effect.
The content of the invention
The shortcomings that primary and foremost purpose of the present invention is to overcome the prior art and deficiency provide a kind of with hair care anti-off effect
Compound plant extract.
Another object of the present invention is to provide the preparation side of the compound plant extract with hair care anti-off effect
Method.
It is still another object of the present invention to provide the applications of the compound plant extract with hair care anti-off effect.
The purpose of the present invention is achieved through the following technical solutions：A kind of compound plant extraction with hair care anti-off effect
Object is prepared by ingredient as follows according to the mass fraction：22.22~33.34 parts of eclipta, 9.26~13.88 parts of Selaginella tamariscina, mountain
7.41~11.11 parts of honeysuckle flower, 7.41~11.11 parts of HERBA PORTULACAE, raw 5.55~8.33 parts of the tuber of stemona, 5.55~8.33 parts of caulis lonicerae,
3.70~5.56 parts of Radix Polygoni Multiflori, raw 3.70~5.56 parts of Radix Astragali, 3.70~5.56 parts of the bark of ash, 1.85~2.77 parts of frosted mulberry leaf, when
Return 1.85~2.77 parts, 1.85~2.77 parts of terminalia flesh, 1.48~2.22 parts of big Radix Rehmanniae, 1.48~2.22 parts of Fructus Mume, rhizoma zingiberis
1.11~1.67 parts, 0.74~1.12 part of lucid asparagus, 0.38~0.56 part of radix salviae miltiorrhizae, 0.38~0.56 part of Chinese gall, granatum
0.38~0.56 part；Summation is 100 parts.
The compound plant extract that there is hair care anti-off effect, preferably by ingredient system as follows according to the mass fraction
It is standby to obtain：22.22~27.78 parts of eclipta, 11.57~12.5 parts of Selaginella tamariscina, 8.5~9.26 parts of Honeysuckle flower, HERBA PORTULACAE 8.5~
9.26 parts, raw 6.94~8.33 parts of the tuber of stemona, 6.94 parts of caulis lonicerae, 4.63~5.56 parts of Radix Polygoni Multiflori, raw 4.63~5.56 parts of Radix Astragali,
4.63~5.56 parts of the bark of ash, 2.31~2.48 parts of frosted mulberry leaf, 2.31~2.47 parts of Radix Angelicae Sinensis, 2.31~2.47 parts of terminalia flesh, big life
1.85~2.22 parts of ground, 1.85~2.22 parts of Fructus Mume, 1.39~1.67 parts of rhizoma zingiberis, 0.93~1.12 part of lucid asparagus, radix salviae miltiorrhizae
0.47~0.56 part, 0.47~0.56 part of Chinese gall, 0.47~0.56 part of granatum；Summation is 100 parts.
The compound plant extract that there is hair care anti-off effect, most preferably by ingredient as follows according to the mass fraction
It is prepared：22.22 parts of eclipta, 12.5 parts of Selaginella tamariscina, 8.5 parts of Honeysuckle flower, 8.5 parts of HERBA PORTULACAE, raw 8.33 parts of the tuber of stemona, caulis lonicerae
6.94 parts, 5.56 parts of Radix Polygoni Multiflori, raw 5.56 parts of Radix Astragali, 5.56 parts of the bark of ash, 2.48 parts of frosted mulberry leaf, 2.47 parts of Radix Angelicae Sinensis, terminalia flesh
2.47 parts, 2.22 parts of big Radix Rehmanniae, 2.22 parts of Fructus Mume, 1.67 parts of rhizoma zingiberis, 1.12 parts of lucid asparagus, 0.56 part of radix salviae miltiorrhizae, Chinese gall
0.56 part, 0.56 part of granatum.
The compound plant extract that there is hair care anti-off effect, most preferably by ingredient as follows according to the mass fraction
It is prepared：
27.78 parts of eclipta, 11.57 parts of Selaginella tamariscina, 9.26 parts of Honeysuckle flower, 9.26 parts of HERBA PORTULACAE, raw 6.94 parts of the tuber of stemona, honeysuckle
6.94 parts of rattan, 4.63 parts of Radix Polygoni Multiflori, raw 4.63 parts of Radix Astragali, 4.63 parts of the bark of ash, 2.31 parts of frosted mulberry leaf, 2.31 parts of Radix Angelicae Sinensis, terminalia flesh
2.31 parts, 1.85 parts of big Radix Rehmanniae, 1.85 parts of Fructus Mume, 1.39 parts of rhizoma zingiberis, 0.93 part of lucid asparagus, 0.47 part of radix salviae miltiorrhizae, Chinese gall
0.47 part, 0.47 part of granatum.
The preparation method of the compound plant extract with hair care anti-off effect, comprises the following steps：
(1) eclipta, Selaginella tamariscina, Honeysuckle flower, HERBA PORTULACAE, the raw tuber of stemona, caulis lonicerae, Radix Polygoni Multiflori, raw Radix Astragali, the bark of ash, white mulberry are taken
Leaf, Radix Angelicae Sinensis, terminalia flesh, big Radix Rehmanniae, Fructus Mume, rhizoma zingiberis, lucid asparagus, radix salviae miltiorrhizae, Chinese gall, granatum totally 19 taste, mix according to quantity
Uniformly, decocting is extracted, separation of solid and liquid；Obtained liquid is stood to layering, is separated again, obtains clear extracting solution；
(2) the clear extracting solution for obtaining step (1) concentrates, and cooling obtains thick paste；
(3) ethyl alcohol is added in into thick paste under stirring, and the ethanol content in thick paste is made to reach mass percent 70
~85%, mixing is stood, and filtering takes filtrate；
(4) filtrate is concentrated, obtains the compound plant extract with hair care anti-off effect.
The number of decocting described in step (1) is preferably 3 times.
The condition of decocting described in step (1) is preferably as follows：8~12 times of amount water are added in for the first time, and 60 are decocted after boiling
~120 minutes；Second and third time is separately added into 6~10 times of amount water, is decocted 40~100 minutes after boiling；Filtering, discards the dregs of a decoction, carries
Liquid is taken to merge, stands clarification, centrifugal filtration obtains clear extracting solution.The quality dosage of water is using traditional Chinese medicinal components gross mass as base
It is accurate.
Separated mode described in step (1) is preferably to centrifuge.
The mode of concentration described in step (2) is preferably to be concentrated under reduced pressure.
The degree of concentration described in step (2) is preferably to be concentrated into every 1ml concentrates to be equivalent to 0.8~1.2 gram of crude drug,
And relative density is 1.15~1.35 at 60 DEG C~70 DEG C.
The condition of cooling described in step (2) be preferably by thick paste place 10~12 it is small when.
The condition of mixing described in step (3) is preferably to stir 20~40 minutes.
When the time of standing described in step (3) is preferably 24 small；The effect of standing is fully to precipitate.
The mode of concentration described in step (4) is preferably to be concentrated under reduced pressure.So as to recycle ethyl alcohol while concentration.
The degree of concentration described in step (4) is preferably to be concentrated into every 1 milliliter of liquid containing primary crude drug about 2.0~2.6
Gram, proportion be 1.05~1.25g/cm3, alcohol content is not higher than 3% in concentrate.
Described has application of the compound plant extract of hair care anti-off effect in hair care articles are prepared.
The hair care articles include shampoo, hair conditioner etc..
A kind of hair care anti-drop liquid shampoo contains the above-mentioned compound plant extract with hair care anti-off effect.
The hair care anti-drop liquid shampoo preferably comprises following ingredient by mass percentage：It is above-mentioned that there is hair care to prevent
The de- compound plant extract 5~30% acted on, laureth ammonium sulfate 16.8~11.2%, Texapon Special 10.4~
15.60%th, dimethiconol 1.6~2.4%, pearlescent flake 1.2~1.8%, coconut oleoyl amine MEA 0.8~1.2%, perfume
Essence 0.48~0.72%, sodium chloride 0.48~0.72%, guar hydroxypropyltrimonium chloride 0.24~0.36%, benzoic acid
Sodium 0.24~0.36%, EDETATE SODIUM 0.12~0.18%, citric acid 0.04~0.06%, Kathon CG CG 0.02~0.04%, water
Surplus；More preferably include following ingredient by mass percentage：The above-mentioned compound plant extract with hair care anti-off effect
15%th, laureth ammonium sulfate 14%, Texapon Special 13%, dimethiconol 2%, pearlescent flake 1.5%, coconut palm
Oleamide MEA 1%, essence 0.6%, sodium chloride 0.6%, guar hydroxypropyltrimonium chloride 0.3%, sodium benzoate
0.3%th, EDETATE SODIUM 0.15%, citric acid 0.05%, Kathon CG CG 0.03%, water surplus.
The preparation method of the hair care anti-drop liquid shampoo, comprises the following steps：
(a) guar hydroxypropyltrimonium chloride first is completely dissolved with water, adds citric acid, stirred complete to citric acid
Fully dissolved；
(b) laureth ammonium sulfate, Texapon Special, pearlescent flake, coconut oleoyl amine MEA are sequentially added and there is hair care
The compound plant extract of anti-off effect, stirs to material and is completely dissolved；
(c) alkaline solution, dimethiconol, essence and sodium-chloride water solution are added in 45 DEG C of next coming in order, stirred
It mixes to obtaining the solution of homogeneous system；Wherein, alkaline solution is that sodium benzoate, EDETATE SODIUM and Kathon CG CG are dissolved in water and are prepared into
It arrives；
(d) filter, be aged, defoaming obtains hair care anti-drop liquid shampoo.
Being completely dissolved the condition of guar hydroxypropyltrimonium chloride described in step (a) with water is：In 20~30rpm
Stirring under be heated to 78~82 DEG C, heat preservation, until guar hydroxypropyltrimonium chloride is completely dissolved.
The speed of stirring described in step (b) is preferably 30~35rpm.
The temperature of stirring described in step (b) is preferably 78~82 DEG C.
The concentration of sodium-chloride water solution described in step (c) is preferably mass percent 20%.
The operation sequentially added in step (b) and step (c) is preferably：Often add in a kind of ingredient, after abundant mixing again
A kind of ingredient under addition.
Filtering described in step (d) is filtered preferably by 80 mesh filters.
The time of ageing described in step (d) is preferably for 24 hours.
The preparation of the prescription of compound of the present invention and its anti-drop liquid shampoo of taking care of hair has been combined closely modern pharmacology medicine again
Effect and science and technology.Eclipta can be used as penetrating agent in prescription, promote the Transdermal absorption of active ingredient；Radix Polygoni Multiflori, frost in prescription
Mulberry leaf can be used as root of hair activating agent, improve and nurse one's health the various enzymatic activitys related with hair, assign root of hair living, promote hair growth；Group
Selaginella tamariscina, the bark of ash can be used as hair growth agent in side, promote hair regeneration；Radix Angelicae Sinensis, radix salviae miltiorrhizae, raw Radix Astragali can be used as micro- follow in prescription
Ring accelerating agent expands scalp capillary, promotes blood circulation, and supplies hair matricyte quantity, activates scalp tissue；It is big in prescription
Radix Rehmanniae, lucid asparagus can be used as hair nourishing agent, supply hair regeneration nutrition；Rhizoma zingiberis can be used as scalp local irritant in prescription,
Minimal irritation scalp is allowed to congested, excited scalp nervous system, so as to recovering trophicity；Honeysuckle flower in prescription, caulis lonicerae,
HERBA PORTULACAE, the raw tuber of stemona can be used as sterilization anti-dandruff and itching-relieving agent, anti-inflammatory, sterilization, anti-dandruff, antipruritic；Chinese gall, granatum in prescription are scolded
Sub- meat, Fructus Mume can be used as convergence hair-strengthening agent, restrain firm root of hair, make hair not easily to fall off.Above-mentioned all medicines form perfect shield
Send out anticreep compound system, with its extract be applied to daily chemical product in, prepare shampoo have nursing scalp and hair-care, prevent or
The effect of reducing epilation, promoting hair metabolic.
The above-mentioned technical proposal of the present invention has following features and advantageous effect compared with prior art：
(1) the present invention is from theory of traditional Chinese medical science to the understanding of hair, and link closely pathogen and pathology of tcm, according to tcm treatment according to syndrome differentiation
Principle prevent and treat prescription, it is relatively easy to overcome prior art prescription, and prescription is according to the defects of being not enough.
(2) prescription raw material provided by the invention is not only natural material, and in daily chemical product laws and regulations requirement is met
In medicine or autonomic drug scope, the prescription raw material of some anti-product-stripping mechanisms of hair care is overcome not in daily chemical product scope, it is impossible in daily use chemicals
The shortcomings that distribution channel.
The present invention except by traditional Chinese medicine theory from numerous reasons of alopecia go hair prescription in addition to, modern medicine of also combining closely
Drug effect and science and technology are managed, penetrating agent, root of hair activating agent, hair growth agent, hair nourishing agent, scalp office are introduced in prescription
The system schemas such as portion's stimulant, sterilization anti-dandruff and itching-relieving agent, convergence hair-strengthening agent, scientific formula is reasonable, manufactured hair care anticreep hair washing
Liquid can penetrate deep into scalp, the Transdermal absorption for promoting active ingredient, improve conditioning hair related activity, assign root of hair living to promote
Hair growth, and scalp capillary can be expanded, promote blood circulation, activate scalp tissue, supply hair regeneration nutrition, moreover it is possible to
Excited scalp nervous system, anti-inflammatory, sterilization, anti-dandruff, antipruritic, the firm root of hair of convergence, promote hair metabolism, prevention to reach
The purpose of epilation.
(4) the preparation method of the extract of compound provided by the invention and its shampoo, can be living in each raw material
Property ingredient fully release, and can guarantee that each active ingredient is absorbed and used to greatest extent, so that the shampoo prepared
It is good not only to prevent alopecia effect, but also has no toxic side effect；The preparation method provided is easy to operate, of low cost, beneficial to industry
Change.
Specific embodiment
With reference to embodiment, the present invention is described in further detail, but the implementation of the present invention is not limited to this.
1 compound of embodiment and its method for preparing extractive one
(1) compound composition
Eclipta 1778g, Selaginella tamariscina 1000g, Honeysuckle flower 680g, HERBA PORTULACAE 680g, raw tuber of stemona 666g, caulis lonicerae 555g, life
Tuber of multiflower knotweed 445g, raw Radix Astragali 445g, bark of ash 445g, frosted mulberry leaf 198g, Radix Angelicae Sinensis 198g, terminalia flesh 198g, big Radix Rehmanniae 178g, Fructus Mume
178g, rhizoma zingiberis 134g, lucid asparagus 90g, radix salviae miltiorrhizae 45g, Chinese gall 45g, granatum 45g.
(2) compound method for preparing extractive
A) eclipta, Selaginella tamariscina, Honeysuckle flower, HERBA PORTULACAE, the raw tuber of stemona, caulis lonicerae, Radix Polygoni Multiflori, raw Radix Astragali, the bark of ash, white mulberry are taken
Leaf, Radix Angelicae Sinensis, terminalia flesh, big Radix Rehmanniae, Fructus Mume, rhizoma zingiberis, lucid asparagus, radix salviae miltiorrhizae, Chinese gall, granatum totally 19 taste, clean cutting,
It is uniformly mixed, is inserted in high-pressure extracting tank by recipe quantity, added water to cook by several times 3 times.80kg purified waters, cold soaking are added in for the first time
After 120 minutes, heating decocts boiling 120 minutes, filters, and filtrate is spare；The dregs of a decoction second add in 64kg purified waters, reheat and decoct
Boiling 90 minutes, filtering, filtrate merges spare with first time filtrate；The dregs of a decoction the 3rd add in 64kg purified waters, and reheat and decoct
Boiling 60 minutes, filtering, filtrate merge with first and second filtrate, obtain extracting solution about 180kg.The dregs of a decoction discard, and extracting solution stands clear
Clearly, centrifugal filtering, filtrate are spare；
B) extracting solution that above-mentioned clarification filters is inserted in vacuum concentration pot, is concentrated under reduced pressure into every 1ml concentrates and is equivalent to
1.0 grams of crude drugs, and the thick paste that relative density is 1.26 is measured at 68 DEG C, thick paste placement 12 cools down when small, obtains thick paste 8.1kg,
It is spare；
C) by above-mentioned thick paste after cooling, it is slowly added to 95% ethyl alcohol 30L under stirring, the ethyl alcohol in thick paste contains
Measure as 75%, stir 30 minutes, after making its abundant mixing, stand 24 it is small when precipitate, filter, obtain filtrate about 34L, it is spare；
D) above-mentioned filtrate, reduced vacuum recycling ethyl alcohol are taken, and is concentrated into every 1 milliliter of liquid and contains about 2.5 grams of primary crude drug, than
Weight is 1.13g/cm3When stop concentration, obtain the uniform thick paste 3.2kg of brown.It is detected through gas chromatography, the content of ethyl alcohol in thick paste
For 0.31%, the uniform thick paste of brown is compound extract, spare.
Embodiment 2：Compound and its method for preparing extractive two
(1) compound composition：
Eclipta 2222g, Selaginella tamariscina 926g, Honeysuckle flower 741g, HERBA PORTULACAE 741g, raw tuber of stemona 555g, caulis lonicerae 555g, raw head
Black 370g, raw Radix Astragali 370g, bark of ash 370g, frosted mulberry leaf 185g, Radix Angelicae Sinensis 185g, terminalia flesh 185g, big Radix Rehmanniae 148g, Fructus Mume
148g, rhizoma zingiberis 111g, lucid asparagus 74g, radix salviae miltiorrhizae 38g, Chinese gall 38g, granatum 38g.
(2) compound method for preparing extractive
A) eclipta, Selaginella tamariscina, Honeysuckle flower, HERBA PORTULACAE, the raw tuber of stemona, caulis lonicerae, Radix Polygoni Multiflori, raw Radix Astragali, the bark of ash, white mulberry are taken
Leaf, Radix Angelicae Sinensis, terminalia flesh, big Radix Rehmanniae, Fructus Mume, rhizoma zingiberis, lucid asparagus, radix salviae miltiorrhizae, Chinese gall, granatum totally 19 taste, clean cutting,
It is uniformly mixed, is inserted in high-pressure extracting tank by recipe quantity, added water to cook by several times 3 times.80kg purified waters, cold soaking are added in for the first time
After 120 minutes, heating decocts boiling 90 minutes, filters, and filtrate is spare；The dregs of a decoction second add in 64kg purified waters, reheat and decoct
Boiling 60 minutes, filtering, filtrate merges spare with first time filtrate；The dregs of a decoction the 3rd add in 64kg purified waters, and reheat and decoct
Boiling 60 minutes, filtering, filtrate merge with first and second filtrate, obtain extracting solution about 184kg.The dregs of a decoction discard, and extracting solution stands clear
Clearly, centrifugal filtering, filtrate are spare；
B) extracting solution that above-mentioned clarification filters is inserted in vacuum concentration pot, is concentrated under reduced pressure into every 1ml concentrates and is equivalent to
1.0 grams of crude drugs, and the thick paste that relative density is 1.23 is measured at 68 DEG C, thick paste placement 12 cools down when small, obtains thick paste 8.2kg,
It is spare；
C) by above-mentioned thick paste after cooling, it is slowly added to 95% ethyl alcohol 30L under stirring, the ethyl alcohol in thick paste contains
Measure as 75%, stir 30 minutes, after making its abundant mixing, stand 20 it is small when precipitate, filter, obtain filtrate about 34L, it is spare；
D) above-mentioned filtrate, reduced vacuum recycling ethyl alcohol are taken, and is concentrated into every 1 milliliter of liquid and contains about 2.3 grams of primary crude drug, than
Stop concentration when weight is 1.12g/cm3, obtain the uniform thick paste 3.5kg of brown.It is detected through gas chromatography, the content of ethyl alcohol in thick paste
For 0.37%, the uniform thick paste of brown is compound extract, spare.
Embodiment 3：Hair care anti-drop liquid shampoo prescription and preparation method thereof
(1) prescription is as shown in table 1：
Table 1
(2) preparation process:
1. the accurate water for claiming mass percent 45% in formula is added in in container, melon glue hydroxypropyl is then slowly added into
Base trimethyl ammonium chloride opens agitating device to agitation revolution 25rpm, is heated to 80 DEG C, and keeps the temperature to melon glue hydroxypropyl
Base trimethyl ammonium chloride is completely dispersed uniformly, adds citric acid, and stirring 8min to material is completely dissolved；
Agitation revolution is adjusted after container contents are completely dissolved to 35rpm 2. confirming and preparing, sequentially adds laureth
Ammonium sulfate, Texapon Special, pearlescent flake, coconut oleoyl amine MEA, compound extract, heat preservation 10min is with up to completely molten
Solution confirms that preparation container contents adjust agitation revolution to 30rpm after being completely dissolved, and logical cooling water temperature；
3. clean container is separately taken to put into sodium benzoate, EDETATE SODIUM, Kathon CG CG, the water of mass percent 3.47% is added in
Stirring and dissolving obtains alkaline solution to clear, spare；Clean container is separately taken to put into sodium chloride again, adds in mass percent
About 20% sodium chloride solution is made to clear in 3% water stirring and dissolving, spare；
4. confirm that above-mentioned 2. step leads to cooling water temperature to 42 DEG C, 3. alkaline solution made from step is added in, stirring is equal
It is even；Dimethiconol, essence are added, is stirred 30 minutes or more；Confirm that material dissolution is complete, be eventually adding 3. step
About 20% sodium chloride solution obtained, stirring 20 minutes is with up to stirring evenly.It is filtered with about 80 mesh filters, PH is examined in sampling
Value, viscosity, color discharge after qualified, when ageing 24 is small, after defoaming, again after the assay was approved, the filling anticreep hair washing that must take care of hair
Liquid.
Embodiment 4：The influence experiment of compound and its extract to animal body hair growth
In order to probe into influence of the compound to animal body hair growth, the present invention is with compound extract through great Bai
Mouse, cavy and rabbit are tested, it is found that compound and its extract of the present invention have the body hair growth of three kinds of animals
Significant facilitation, experimental method and result are as follows:
1 reagent
1.1 drug：Two groups of compound extracts, are performed as described above example 1 and embodiment 2 is made, use preceding every 1 gram of compound
The ethanol water 5ml that composition extract adds in 60% is diluted and stirred evenly, and obtains reagent liquid, spare；
1.2 blank control:60% ethanol water, it is spare.
2 experimental animals and environment
Big white mouse, male, 200 ± 20g of weight；Cavy, male, 350 ± 35g of weight；Rabbit, male, weight 2.3 ±
0.3kg；Guangdong Medical Lab Animal Center provides, animal quality verification of conformity number：No.44411600000901.Experiment
Animal uses credit number：SYXK (Guangdong) 2013-0002.
Experimental situation condition：25 DEG C ± 2 DEG C of temperature, relative humidity 60% ± 10%, interior are led to based on natural lighting
Wind is good, and environment is kept quite, SPF grades of experimental animal environmental facilities.
3 experimental methods and result
3.1 big white mouse experimental methods and result
3.1.1 big white mouse experimental method
Experiment divides blank control group and two groups of compound groups, every group 12, cuts off back 3 × 3cm of same area2Chaeta,
Skin is notably avoided damage to during cropping；Removing hair-fields coating 0.4ml/, only two groups of compound groups are respectively adopted after when cropping 24 is small
The reagent liquid of compound extract described in above-described embodiment 1-2, control group apply 60% ethanol water, once a day,
After continuous 12 days, the careful clip 3 × 3cm2The new piliation at place, weighs.
3.1.1 big white mouse experimental result
Influence experimental result of the compound to big white mouse body hair growth is shown in Table 2.
Influence experimental result of 2 compound of table to big white mouse body hair growth
★ P ＜ 0.05 are compared with the control group
Comparison among groups conspicuousness is carried out, design parameter is shown in Table 2.The result shows that body of two groups of compounds to big white mouse
Hair growth has significant facilitation.
3.2 guinea-pig studies methods and result
3.2.1 guinea-pig studies method
Experiment divides blank control group and two groups of compound groups, every group 10, cuts off back 3 × 3cm of same area2Chaeta,
Skin is notably avoided damage to during cropping；Removing hair-fields coating 0.4ml/, only two groups of compound groups are respectively adopted after when cropping 24 is small
The reagent liquid of compound extract described in above-described embodiment 1-2, control group apply 60% ethanol water, once a day,
After continuous 12 days, the careful clip 3 × 3cm2The new piliation at place, weighs.
3.2.2 guinea-pig studies result
Influence experimental result of the compound to cavy body hair growth is shown in Table 3.
Influence experimental result of 3 compound of table to cavy body hair growth
★ ★ P ＜ 0.01 are compared with the control group
Comparison among groups conspicuousness is carried out, design parameter is shown in Table 3.The result shows that chaeta of two groups of compounds to cavy
Growth has the facilitation of highly significant.
3.3 rabbit experiment methods and result
3.3.1 rabbit experiment method
Experiment divides blank control group and two groups of compound groups, every group 8, cuts off back 4 × 4cm of same area2Chaeta, cut
Skin is notably avoided damage to during hair；Removing hair-fields coating 0.4ml/, only two groups of compound groups are respectively adopted after when cropping 24 is small
The reagent liquid of the compound extract described in embodiment 1-2 is stated, control group applies 60% ethanol water, once a day, even
After 20 days continuous, the careful clip 4 × 4cm2The new piliation at place, weighs.
3.3.2 rabbit experiment result
Influence experimental result of the compound to rabbit body hair growth is shown in Table 4.
Influence experimental result of 4 compound of table to rabbit body hair growth
★ P ＜ 0.05 are compared with the control group
Comparison among groups conspicuousness is carried out, design parameter is shown in Table 4.The result shows that chaeta of two groups of compounds to rabbit
Growth has significant facilitation.
4 conclusions
The present invention is tested with two groups of compound extracts through big white mouse, cavy and rabbit, it is found that the present invention is multiple
Square composition and its extract have the body hair growth of three kinds of animals significant facilitation, experimental result prompting：The present invention
Compound has significant facilitation to body hair growth.
Embodiment 5：The influence experiment of compound and its extract to animal skin itch inhibitory action
In order to probe into influence of the compound to animal skin itch inhibitory action, the present invention is extracted with compound
Object is itched through cavy feels that reaction is tested, it is found that compound and its extract of the present invention itch to cavy feel reaction with notable
Inhibitory action, experimental method and result are as follows:
1 reagent
1.1 drug：Two groups of compound extracts, are performed as described above example 1 and embodiment 2 is made, use preceding every 1 gram of compound
The ethanol water 5ml that composition extract adds in 60% is diluted and stirred evenly, and obtains reagent liquid, spare；
1.2 blank control：60% ethanol water, it is spare.
2 experimental animals and environment
Cavy, male, 350 ± 35g of weight；Guangdong Medical Lab Animal Center provides, and animal quality verification of conformity is compiled
Number：No.44411600000901.Experimental animal uses credit number：SYXK (Guangdong) 2013-0002.
Experimental situation condition:25 DEG C ± 2 DEG C of temperature, relative humidity 60% ± 10%, interior are led to based on natural lighting
Wind is good, and environment is kept quite, SPF grades of experimental animal environmental facilities.
3 experimental methods and result
3.1 experimental method
Experiment divides blank control group and two groups of compound groups, every group 10, first by cavy unhairing, cut during experiment, then drips
Adding liquid 0.1ml, the reagent liquid of the compound extract described in above-described embodiment 1-2 is respectively adopted in two groups of compound groups, and
Animal is placed in appropriate location and is kept, avoids fluid loss so that liquid is fully absorbed, and interval repeats drop medicine 1 after 6 minutes
It is secondary, then cause agent of itching through drop histamine (Histamine) conduct in 6 minutes；60% ethanol water is added dropwise in control group, measures threshold of itching.
3.2 experimental result
Compound is shown in Table 5 to the influence experimental result of guinea pig skin itch inhibitory action.
5 compound of table is to the influence experimental result of guinea pig skin itch inhibitory action
★ ★ P ＜ 0.01 are compared with the control group
Comparison among groups conspicuousness is carried out, design parameter is shown in Table 5.The result shows that two groups of compounds itch to histamine cause
There is significant itching-relieving action.
4 conclusions
The present invention is tested with two groups of compound extracts through cavy, is found compound of the present invention and its is carried
Object is taken, which to itch histamine cause, significant itching-relieving action.Experimental result is prompted：Compound of the present invention is to there is body itch
Significant itching-relieving action.
Embodiment 6：Compound extract prepares the clinical trial of hair care anti-drop liquid shampoo
The present invention is gone to send out by traditional Chinese medicine theory from numerous reasons of alopecia, and for ultimately resulting in, scalp is greasy, scalp
Fungi (and bacterium) infection, scalp life bits itch, scalp capillary blood cycle not smooth, scalp tissue hair regeneration nutrition supplying
Attenuate easily de- etc. the symptoms that soften to deficiency, hair root, introduces penetrating agent, root of hair activating agent, hair growth agent, trichotrophy
The natural plant Chineses prescriptions such as agent, scalp local irritant, sterilization anti-dandruff and itching-relieving agent, convergence hair-strengthening agent, it is anti-to have invented this hair care
De- shampoo；This anti-drop liquid shampoo can penetrate deep into scalp, the Transdermal absorption for promoting active ingredient, improve conditioning hair correlation
Activity assigns root of hair living to promote hair growth, and can expand scalp capillary, promote blood circulation, activate scalp tissue, supply
Give hair regeneration nutrition, moreover it is possible to which excited scalp nervous system, anti-inflammatory, sterilization, anti-dandruff, antipruritic, the firm root of hair of convergence promote to reach
Into hair metabolism, the purpose of prevention epilation.This hair care anti-drop liquid shampoo, can be with this public affairs to prevent based on epilation
The generating hair elite liquid (separately declaring) of another invention of department is used cooperatively, and can obtain more preferably effect.
This experiment is attenuated softening, uninteresting and come off for the volunteer 60 of Clinical symptoms with the size hair that comes off, using this shield
The blank shampoo for sending out anti-drop liquid shampoo and non-drug containing carries out curative effect comparison, is now reported as follows：
1 clinical data
1.1 general information
Two groups 60 are with hair is dilute, patient of alopecia, are randomly divided into two groups of carry out clinical treatment observations.Treatment group
In 30, man 28, female 2；The oldest 65 years old, minimum 23 years old, average (43 ± 7.8) year；The course of disease is most 31 years long, most short by 2
Year, average (25 ± 1) year.In control group 30, man 27, female 3；It is the oldest 64 years old, 24 years old minimum, average (42 ±
7.6) year；The course of disease is most 30 years long, most 2 years half short, average (25 ± 1.2) year.
1.2 diagnostic criteria
With reference to written by Zhang Zhi's gift《Chinese and Western combines skin cypridology》The related standard of middle formulation is drafted.Include feeling for judge
Symptom includes itching of the scalp, and the greasy luminous or hair drying of hair is withered, has a large amount of scalp scales of skin that peel offs, in the tiny chaff of canescence more
Gradually rareness attenuates for not plump shape, with the passing of time hair, and new hair tonic is more and more soft, and matt, baldness area skin smooth, only a small amount of fine hair on birds or animals
Hair, anterior hair line line both sides retreat, into great number.
2 therapies
2.1 treatment group
This treatment group uses hair care anti-drop liquid shampoo prepared by embodiment 3, washes hair once per the daily shampoo, every time first
The shampoo is smeared in affected part, massage 5-10 minutes is gently rubbed with hand, clear water rinses；It repeats and smears the shampoo in affected part, use
Hand gently rubs massage 5-10 minutes, and clear water is rinsed well.60 days as a treatment course, responder can long-time services.
2.2 control group
This control group uses the blank shampoo for being not added with compound extract prepared in embodiment 3, application process
With treatment group hair care anti-drop liquid shampoo method it is identical.
3 treatment results
3.1 criterion of therapeutical effect reference literatures《Chinese journal of dermatology, 2003,30 (4):230-231》The related mark of middle formulation
Standard is drafted.It is effective:Comb hair experiment trichomadesis radical reduces 50% before relatively treating；Effectively:Comb hair experiment trichomadesis radical compared with
Reduce by >=20%, but ＜ 50% before treatment；It is invalid:Comb hair experiment trichomadesis radical reduces ＜ 20% before relatively treating.
3.2 treatment results (are shown in Table 6)
6 two groups for the treatment of results of table and curative effect compare
| Group | n | It is effective | Effectively | It is invalid | Total effective rate (%) |
| Treatment group | 30 | 7 | 20 | 3 | 90.0* |
| Control group | 30 | 5 | 14 | 11 | 63.0 |
Note:Compared with the control group, * P ＜ 0.05
As a result：Confirmation is tried out through tens of people：Behind hair care anti-drop liquid shampoo day 60 days with the present invention, really to anti-alopecia-stopping
With good effect, and there are the effects that antipruritic anti-dandruff, antistatic, be easy to comb shaping, black hair, total effective rate 90%.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention and from above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (10)
1. a kind of compound plant extract with hair care anti-off effect, it is characterised in that by ingredient as follows according to the mass fraction
It is prepared：22.22~33.34 parts of eclipta, 9.26~13.88 parts of Selaginella tamariscina, 7.41~11.11 parts of Honeysuckle flower, HERBA PORTULACAE
7.41~11.11 parts, raw 5.55~8.33 parts of the tuber of stemona, 5.55~8.33 parts of caulis lonicerae, 3.70~5.56 parts of Radix Polygoni Multiflori, raw Radix Astragali
3.70~5.56 parts, 3.70~5.56 parts of the bark of ash, 1.85~2.77 parts of frosted mulberry leaf, 1.85~2.77 parts of Radix Angelicae Sinensis, terminalia flesh 1.85
~2.77 parts, 1.48~2.22 parts of big Radix Rehmanniae, 1.48~2.22 parts of Fructus Mume, 1.11~1.67 parts of rhizoma zingiberis, lucid asparagus 0.74~
1.12 parts, 0.38~0.56 part of radix salviae miltiorrhizae, 0.38~0.56 part of Chinese gall, 0.38~0.56 part of granatum；Summation is 100 parts.
2. the compound plant extract with hair care anti-off effect according to claim 1, it is characterised in that by pressing as follows
The ingredient of mass fraction meter is prepared：22.22~27.78 parts of eclipta, 11.57~12.5 parts of Selaginella tamariscina, Honeysuckle flower 8.5~
9.26 parts, 8.5~9.26 parts of HERBA PORTULACAE, raw 6.94~8.33 parts of the tuber of stemona, 6.94 parts of caulis lonicerae, 4.63~5.56 parts of Radix Polygoni Multiflori,
Raw 4.63~5.56 parts of Radix Astragali, 4.63~5.56 parts of the bark of ash, 2.31~2.48 parts of frosted mulberry leaf, 2.31~2.47 parts of Radix Angelicae Sinensis, myrobalan
2.31~2.47 parts of meat, 1.85~2.22 parts of big Radix Rehmanniae, 1.85~2.22 parts of Fructus Mume, 1.39~1.67 parts of rhizoma zingiberis, lucid asparagus
0.93~1.12 part, 0.47~0.56 part of radix salviae miltiorrhizae, 0.47~0.56 part of Chinese gall, 0.47~0.56 part of granatum；Summation is
100 parts.
3. the compound plant extract with hair care anti-off effect according to claim 2, it is characterised in that by pressing as follows
The ingredient of mass fraction meter is prepared：22.22 parts of eclipta, 12.5 parts of Selaginella tamariscina, 8.5 parts of Honeysuckle flower, 8.5 parts of HERBA PORTULACAE, life
8.33 parts of the tuber of stemona, 6.94 parts of caulis lonicerae, 5.56 parts of Radix Polygoni Multiflori, raw 5.56 parts of Radix Astragali, 5.56 parts of the bark of ash, 2.48 parts of frosted mulberry leaf, when
Return 2.47 parts, it is 2.47 parts of terminalia flesh, 2.22 parts of big Radix Rehmanniae, 2.22 parts of Fructus Mume, 1.67 parts of rhizoma zingiberis, 1.12 parts of lucid asparagus, purple red
0.56 part of ginseng, 0.56 part of Chinese gall, 0.56 part of granatum；
Or it is prepared by ingredient as follows according to the mass fraction：
27.78 parts of eclipta, 11.57 parts of Selaginella tamariscina, 9.26 parts of Honeysuckle flower, 9.26 parts of HERBA PORTULACAE, raw 6.94 parts of the tuber of stemona, caulis lonicerae
6.94 parts, 4.63 parts of Radix Polygoni Multiflori, raw 4.63 parts of Radix Astragali, 4.63 parts of the bark of ash, 2.31 parts of frosted mulberry leaf, 2.31 parts of Radix Angelicae Sinensis, terminalia flesh
2.31 part, 1.85 parts of big Radix Rehmanniae, 1.85 parts of Fructus Mume, 1.39 parts of rhizoma zingiberis, 0.93 part of lucid asparagus, 0.47 part of radix salviae miltiorrhizae, Chinese gall
0.47 part, 0.47 part of granatum.
4. there is the preparation method of the compound plant extract of hair care anti-off effect, feature described in any one of claims 1 to 3
It is to comprise the following steps：
(1) take eclipta, Selaginella tamariscina, Honeysuckle flower, HERBA PORTULACAE, the raw tuber of stemona, caulis lonicerae, Radix Polygoni Multiflori, raw Radix Astragali, the bark of ash, frosted mulberry leaf, when
Return, terminalia flesh, big Radix Rehmanniae, Fructus Mume, rhizoma zingiberis, lucid asparagus, radix salviae miltiorrhizae, Chinese gall, granatum totally 19 taste, be uniformly mixed according to quantity,
Decocting is extracted, separation of solid and liquid；Obtained liquid is stood to layering, is separated again, obtains clear extracting solution；
(2) the clear extracting solution for obtaining step (1) concentrates, and cooling obtains thick paste；
(3) ethyl alcohol is added in into thick paste under stirring, and make the ethanol content in thick paste reach mass percent 70~
85%, mixing is stood, and filtering takes filtrate；
(4) filtrate is concentrated, obtains the compound plant extract with hair care anti-off effect.
5. there is the preparation method of the compound plant extract of hair care anti-off effect according to claim 4, it is characterised in that：
The condition of decocting described in step (1) is as follows：8~12 times of amount water are added in for the first time, and 60~120 points are decocted after boiling
Clock；Second and third time is separately added into 6~10 times of amount water, is decocted 40~100 minutes after boiling；Filtering, discards the dregs of a decoction, and extracting solution closes
And clarification is stood, centrifugal filtration obtains clear extracting solution.
6. there is the preparation method of the compound plant extract of hair care anti-off effect according to claim 4, it is characterised in that：
The mode of concentration described in step (2) is to be concentrated under reduced pressure；
The degree of concentration described in step (2) is equivalent to 0.8~1.2 gram of crude drug to be concentrated into every 1ml concentrates, and at 60 DEG C
Relative density is 1.15~1.35 at~70 DEG C；
The mode of concentration described in step (4) is to be concentrated under reduced pressure；
To be concentrated into, every 1 milliliter of liquid contains about 2.0~2.6 grams of primary crude drug to the degree of concentration described in step (4), proportion is
1.05~1.25g/cm3, alcohol content is not higher than 3% in concentrate.
7. the compound plant extract that claims 1 to 3 any one of them has hair care anti-off effect is preparing hair care articles
In application.
8. a kind of hair care anti-drop liquid shampoo, it is characterised in that：There is hair care anticreep containing claims 1 to 3 any one of them
The compound plant extract of effect.
9. hair care anti-drop liquid shampoo according to claim 8, it is characterised in that comprising it is following by mass percentage into
Point：It is above-mentioned have the hair care compound plant extract 5~30% of anti-off effect, laureth ammonium sulfate 16.8~11.2%,
Texapon Special 10.4~15.60%, dimethiconol 1.6~2.4%, pearlescent flake 1.2~1.8%, cocounut oil acyl
Amine MEA 0.8~1.2%, essence 0.48~0.72%, sodium chloride 0.48~0.72%, guar hydroxypropyltrimonium chloride
0.24~0.36%, sodium benzoate 0.24~0.36%, EDETATE SODIUM 0.12~0.18%, citric acid 0.04~0.06%, card
Loose CG 0.02~0.04%, water surplus.
10. the preparation method of the hair care anti-drop liquid shampoo described in claim 9, it is characterised in that comprise the following steps：
(a) guar hydroxypropyltrimonium chloride first is completely dissolved with water, adds citric acid, stirred completely molten to citric acid
Solution；
(b) laureth ammonium sulfate, Texapon Special, pearlescent flake, coconut oleoyl amine MEA are sequentially added and there is hair care anticreep
The compound plant extract of effect, stirs to material and is completely dissolved；
(c) alkaline solution, dimethiconol, essence and sodium-chloride water solution are added in 45 DEG C of next coming in order, stirring is extremely
Obtain the solution of homogeneous system；Wherein, alkaline solution is that sodium benzoate, EDETATE SODIUM and Kathon CG CG are dissolved in water and are prepared；
(d) filter, be aged, defoaming obtains hair care anti-drop liquid shampoo.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109288769A (en) * | 2018-09-25 | 2019-02-01 | 士齐生物研发中心（苏州工业园区）有限公司 | A kind of efficient moisture-retention anti-aging Essence and preparation method thereof based on the water by Tian Chi Lake of Mountain Baitou |
| CN113499420A (en) * | 2021-07-23 | 2021-10-15 | 青岛美芝生物技术有限公司 | Traditional Chinese medicine composition for changing white hair into black hair |
| CN113679650A (en) * | 2021-09-18 | 2021-11-23 | 韶关市曲江美达多食品加工有限公司 | Asparagus cochinchinensis shampoo with effects of hairdressing and hair care |
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| CN102274473A (en) * | 2011-07-15 | 2011-12-14 | 广州市娇兰化妆品有限公司 | Compound natural plant hair loss preventing liquid and preparation method and application thereof in shampoo liquid |
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| CN109288769A (en) * | 2018-09-25 | 2019-02-01 | 士齐生物研发中心（苏州工业园区）有限公司 | A kind of efficient moisture-retention anti-aging Essence and preparation method thereof based on the water by Tian Chi Lake of Mountain Baitou |
| CN113499420A (en) * | 2021-07-23 | 2021-10-15 | 青岛美芝生物技术有限公司 | Traditional Chinese medicine composition for changing white hair into black hair |
| CN113679650A (en) * | 2021-09-18 | 2021-11-23 | 韶关市曲江美达多食品加工有限公司 | Asparagus cochinchinensis shampoo with effects of hairdressing and hair care |
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