CN114848554A - Plant compound for preventing hair loss and growing hair and preparation method thereof - Google Patents
Plant compound for preventing hair loss and growing hair and preparation method thereof Download PDFInfo
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- CN114848554A CN114848554A CN202210575529.0A CN202210575529A CN114848554A CN 114848554 A CN114848554 A CN 114848554A CN 202210575529 A CN202210575529 A CN 202210575529A CN 114848554 A CN114848554 A CN 114848554A
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- 210000004209 hair Anatomy 0.000 title claims abstract description 88
- 150000001875 compounds Chemical class 0.000 title claims abstract description 79
- 238000002360 preparation method Methods 0.000 title claims abstract description 53
- 230000003658 preventing hair loss Effects 0.000 title claims abstract description 10
- 241000196324 Embryophyta Species 0.000 claims abstract description 79
- 239000000284 extract Substances 0.000 claims abstract description 68
- 238000002156 mixing Methods 0.000 claims abstract description 59
- 239000000843 powder Substances 0.000 claims abstract description 51
- 239000010495 camellia oil Substances 0.000 claims abstract description 48
- 239000002245 particle Substances 0.000 claims abstract description 34
- 229920002752 Konjac Polymers 0.000 claims abstract description 30
- 235000010485 konjac Nutrition 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000008367 deionised water Substances 0.000 claims abstract description 26
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 26
- 229920001184 polypeptide Polymers 0.000 claims abstract description 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 26
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 26
- 210000004911 serous fluid Anatomy 0.000 claims abstract description 26
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 25
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 25
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 25
- 235000011477 liquorice Nutrition 0.000 claims abstract description 25
- 244000247812 Amorphophallus rivieri Species 0.000 claims abstract description 24
- 235000001206 Amorphophallus rivieri Nutrition 0.000 claims abstract description 24
- 244000286838 Eclipta prostrata Species 0.000 claims abstract description 24
- 239000000252 konjac Substances 0.000 claims abstract description 24
- 241000830535 Ligustrum lucidum Species 0.000 claims abstract description 23
- 241000405414 Rehmannia Species 0.000 claims abstract description 23
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 23
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 239000009636 Huang Qi Substances 0.000 claims abstract description 13
- 229940107666 astragalus root Drugs 0.000 claims abstract description 13
- 238000000227 grinding Methods 0.000 claims abstract description 13
- 229940069445 licorice extract Drugs 0.000 claims abstract description 12
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 44
- 201000004384 Alopecia Diseases 0.000 claims description 37
- 238000004140 cleaning Methods 0.000 claims description 23
- 238000001035 drying Methods 0.000 claims description 22
- 238000003825 pressing Methods 0.000 claims description 22
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims description 15
- 239000007853 buffer solution Substances 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 14
- 239000004519 grease Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 108090000145 Bacillolysin Proteins 0.000 claims description 11
- 102000035092 Neutral proteases Human genes 0.000 claims description 11
- 108091005507 Neutral proteases Proteins 0.000 claims description 11
- 239000010779 crude oil Substances 0.000 claims description 11
- 238000005520 cutting process Methods 0.000 claims description 11
- 238000004108 freeze drying Methods 0.000 claims description 11
- 238000000703 high-speed centrifugation Methods 0.000 claims description 11
- 238000012216 screening Methods 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 11
- 240000000774 Cunila origanoides Species 0.000 claims description 10
- 235000018274 Cunila origanoides Nutrition 0.000 claims description 10
- 235000014866 Dictamnus albus Nutrition 0.000 claims description 10
- 238000005119 centrifugation Methods 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 10
- 239000002131 composite material Substances 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 4
- 238000004090 dissolution Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 238000012360 testing method Methods 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 3
- 239000006071 cream Substances 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 description 24
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- 230000003656 anti-hair-loss Effects 0.000 description 13
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- 239000000047 product Substances 0.000 description 10
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- 230000003676 hair loss Effects 0.000 description 7
- 208000024963 hair loss Diseases 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 210000004761 scalp Anatomy 0.000 description 5
- 230000003803 hair density Effects 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 3
- 208000001840 Dandruff Diseases 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 208000004631 alopecia areata Diseases 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000003648 hair appearance Effects 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 230000036619 pore blockages Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 206010001766 Alopecia totalis Diseases 0.000 description 1
- 206010001767 Alopecia universalis Diseases 0.000 description 1
- 208000025309 Hair disease Diseases 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 208000032775 alopecia universalis congenita Diseases 0.000 description 1
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- 239000008280 blood Substances 0.000 description 1
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- 230000036770 blood supply Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000003450 growing effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical Kinetics & Catalysis (AREA)
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- Natural Medicines & Medicinal Plants (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a plant compound for preventing hair loss and growing hair and a preparation method thereof, belonging to the technical field of daily chemical products. The plant compound comprises the following raw materials in percentage by weight: astragalus root: 100-150 parts of glossy privet fruit: 80-120 parts of cacumen biotae: 60-80 parts of prepared rehmannia root: 40-70 parts of cortex dictamni: 30-60 parts of eclipta alba: 30-50 parts of camellia oil extract: 15-25 parts, licorice extract: 2-10 parts of konjak polypeptide extract: 1-5 parts, and the preparation comprises the following steps: grinding radix astragali, glossy privet fruit, cacumen biotae, prepared rehmannia root, cortex dictamni and eclipta alba into powder, wherein the particle size of the powder is 1000 meshes, and mixing the powder with deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the camellia oil extract, the liquorice extract and the konjac polypeptide extract. Tests show that the hair-growing and hair-blackening cream has better effects of preventing hair loss, growing hair, blackening hair and the like.
Description
Technical Field
The invention belongs to the technical field of daily chemical products, and particularly relates to a plant compound for preventing alopecia and growing hair and a preparation method thereof.
Background
After the middle-aged, the function of internal organs is reduced with the age, the metabolism surface is depressed, and the aging of the human body is promoted. With the development of economy, the pace of modern life is accelerated and the pressure of life is increased, because immune dysfunction and the cause of infection by the pathogenic factors such as infection or tea diseases cause the hair follicle and the hair mother cell to shrink, the hair diseases such as white hair, alopecia, halter and the like to have higher and higher morbidity, and the modern life is troubled more and more. Alopecia not only affects the beauty, but also causes bad emotions such as self-inferior, depression and the like to the psychology of patients, thereby affecting normal work, life and social activities. Alopecia can be classified into seborrheic alopecia, premature alopecia, alopecia areata, alopecia totalis, alopecia universalis, postpartum alopecia and the like according to symptoms, and no specific medicine can treat alopecia at present.
Traditional Chinese medicine considers that alopecia is mostly caused by physical dysfunction, and the pathogenesis of alopecia is caused by both mental and nutritional reasons. The melancholy can cause damage to the liver, the kidney, the heart and the spleen, and the hair loses nutrition and falls off; or alopecia due to deficiency of blood and insufficiency of blood supply to scalp and hair root.
However, the existing shampoo is generally prepared by mixing chemically synthesized substances at a later stage, has the functions of washing hair and preventing hair from being damaged after long-term use, and can damage hair follicles of users in serious cases; the existing people are stressed and stay up all night, the hair follicle health of the user is also influenced, the hair loss and hair loss of the user can occur after a long time, the mood of the user can be influenced after the hair loss and hair loss of the user, and the beauty lover is stricken greatly.
Disclosure of Invention
1. Problems to be solved
Aiming at the problems in the prior art, the invention provides the anti-hair loss and hair growth plant compound and the preparation method thereof, and the anti-hair loss and hair growth plant compound has better anti-hair loss, hair growth, hair blackening and other effects.
2. Technical scheme
In order to solve the above problems, the present invention adopts the following technical solutions.
A plant composition for preventing alopecia and promoting hair growth,
the composite material comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing the hair,
the composite material comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing hair described above,
the composite material comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing hair described above,
the astragalus root, the glossy privet fruit, the cacumen biotae, the prepared rehmannia root, the dittany bark and the eclipta alba are purchased from Chinese traditional medicine company Limited.
In the plant compound for preventing and growing hair described above,
the preparation method of the camellia oil extract comprises the following steps:
screening, cleaning and peeling camellia oil seeds, and drying at 85 ℃ for later use; crushing camellia oil seeds in a crusher to obtain crushed seed kernels; sending the crushed kernels into a hydraulic presser for pressing, wherein the pressing process parameters are as follows: feeding at 55 deg.C, squeezing at 60 deg.C under 12MPa for 20min for 3 times to obtain crude oil; and (4) delivering the mixture into a low-temperature centrifuge for high-speed centrifugation, wherein the rotating speed is 20000rpm, and taking the upper-layer grease.
In the plant compound for preventing and growing hair described above,
the preparation method of the licorice extract comprises the following steps:
drying liquorice, cutting into particles, mixing the particles with anhydrous acetone in a ratio of 1: 10, the mixing temperature is 65 ℃, standing extraction is carried out for 6 hours, centrifugation is carried out at 10000rpm for 10min, and supernate is collected and rotary evaporated to form the acetone anhydrous.
In the plant compound for preventing and growing hair described above,
the preparation method of the konjac polypeptide extract comprises the following steps:
cleaning and peeling konjak, crushing and stirring at low temperature, adding Tris-HCl buffer solution and neutral protease for ultrasonic-assisted dissolution, wherein the concentration of the Tris-HCl buffer solution is 0.8M, the pH value of the Tris-HCl buffer solution is 6.8-7.0, centrifuging, taking supernatant, and freeze-drying to obtain the konjak.
A preparation method of a plant compound for preventing hair loss and growing hair comprises the following steps:
grinding radix astragali, glossy privet fruit, cacumen biotae, prepared rehmannia root, cortex dictamni and eclipta alba into powder, wherein the particle size of the powder is 1000 meshes, and mixing the powder with deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the camellia oil extract, the liquorice extract and the konjac polypeptide extract.
3. Advantageous effects
Compared with the prior art, the invention has the beneficial effects that:
the product designed by the application has a good hair loss prevention and hair growth effect, the hair density of the hair can reach 75.7% by using the product for six months, and the using amount is only 1 g/time. The three extracts (camellia oil extract, liquorice extract and konjac polypeptide extract) play a key role, and are mutually synergistic with other active substances to improve the blood circulation of the scalp, mainly increase and form the capillaries around the hair follicle, provide sufficient nutrition for the hair, improve the activity of the hair follicle, and simultaneously can improve the activity of hair papilla cells so as to prevent pore blockage caused by vigorous oil secretion, accelerate alopecia, and promote new hair growth by active ingredients permeating into the hair follicle. Therefore, the hair loss can be effectively prevented, the hair growth can be promoted, and the scalp allergy can not be caused. The preparation method is simple and convenient, and is convenient for large-scale production. Meanwhile, clinical experiments are carried out, after the hair conditioner is used for 7 days, the product prepared in the embodiment 5 of the invention has a good effect, after the product is continuously used for 15 days, the hair is gradually blackish and bright, soft and smooth, and after 1 month, dandruff, hair oil and head itch are greatly reduced, so that the hair is bright and glossy and is rich in elasticity.
Detailed Description
Example 1
The anti-hair loss and hair growth promoting plant compound comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing hair described above,
the astragalus root, the glossy privet fruit, the cacumen biotae, the prepared rehmannia root, the dittany bark and the eclipta alba are purchased from Chinese traditional medicine company Limited.
In the plant compound for preventing and growing hair described above,
the preparation method of the camellia oil extract comprises the following steps:
screening, cleaning and peeling camellia oil seeds, and drying at 85 ℃ for later use; crushing camellia oil seeds in a crusher to obtain crushed seed kernels; the crushed kernel is sent into a hydraulic presser for pressing, wherein the pressing technological parameters are as follows: feeding at 55 deg.C, squeezing at 60 deg.C under 12MPa for 20min for 3 times to obtain crude oil; and (4) delivering the mixture into a low-temperature centrifuge for high-speed centrifugation, wherein the rotating speed is 20000rpm, and taking the upper-layer grease.
In the plant compound for preventing and growing hair described above,
the preparation method of the licorice extract comprises the following steps:
drying liquorice, cutting into particles, mixing the particles with anhydrous acetone in a ratio of 1: 10, standing and extracting at the mixing temperature of 65 ℃ for 6h, centrifuging at low temperature of 10000rpm for 10min, collecting supernate, and rotationally evaporating anhydrous acetone to obtain the product.
In the plant compound for preventing and growing hair described above,
the preparation method of the konjac polypeptide extract comprises the following steps:
cleaning rhizoma Amorphophalli, peeling, crushing at low temperature, stirring, adding Tris-HCl buffer solution with concentration of 0.8M and neutral protease with pH of 6.8-7.0, and ultrasonically dissolving with-20 deg.C freeze-drying after centrifuging (5000 rpm).
The preparation method of the plant compound for preventing alopecia and growing hair comprises the following steps:
grinding radix astragali, glossy privet fruit, cacumen biotae, prepared rehmannia root, cortex dictamni and eclipta alba into powder, wherein the particle size of the powder is 1000 meshes, and mixing the powder with deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the camellia oil extract, the liquorice extract and the konjac polypeptide extract, wherein the mixing temperature is 35 ℃.
Example 2
The anti-hair loss and hair growth promoting plant compound comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing hair described above,
the astragalus root, the glossy privet fruit, the cacumen biotae, the prepared rehmannia root, the dittany bark and the eclipta alba are purchased from Chinese traditional medicine company Limited.
In the plant compound for preventing and growing the hair,
the preparation method of the camellia oil extract comprises the following steps:
screening, cleaning and peeling camellia oil seeds, and drying at 85 ℃ for later use; crushing camellia oil seeds in a crusher to obtain crushed seed kernels; sending the crushed kernels into a hydraulic presser for pressing, wherein the pressing process parameters are as follows: feeding at 55 deg.C, barrel temperature of 60 deg.C, squeezing pressure of 12MPa, squeezing time of 20min, and squeezing times of 3 times to obtain crude oil; and (4) delivering the mixture into a low-temperature centrifuge for high-speed centrifugation, wherein the rotating speed is 20000rpm, and taking the upper-layer grease.
In the plant compound for preventing and growing hair described above,
the preparation method of the licorice extract comprises the following steps:
drying liquorice, cutting into particles, mixing the particles with anhydrous acetone in a ratio of 1: 10, the mixing temperature is 65 ℃, standing extraction is carried out for 6 hours, centrifugation is carried out at 10000rpm for 10min, and supernate is collected and rotary evaporated to form the acetone anhydrous.
In the plant compound for preventing and growing the hair,
the preparation method of the konjac polypeptide extract comprises the following steps:
cleaning rhizoma Amorphophalli, peeling, crushing at low temperature, stirring, adding Tris-HCl buffer solution with concentration of 0.8M and neutral protease with pH of 6.8-7.0, and ultrasonically dissolving with-20 deg.C freeze-drying after centrifuging (5000 rpm).
The preparation method of the plant compound for preventing alopecia and growing hair comprises the following steps:
grinding radix astragali, glossy privet fruit, cacumen biotae, prepared rehmannia root, cortex dictamni and eclipta alba into powder, wherein the particle size of the powder is 1000 meshes, and mixing the powder with deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the camellia oil extract, the liquorice extract and the konjac polypeptide extract, wherein the mixing temperature is 35 ℃.
Example 3
The anti-hair loss and hair growth promoting plant compound comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing hair described above,
the astragalus root, the glossy privet fruit, the cacumen biotae, the prepared rehmannia root, the dittany bark and the eclipta alba are purchased from Chinese traditional medicine company Limited.
In the plant compound for preventing and growing hair described above,
the preparation method of the camellia oil extract comprises the following steps:
screening, cleaning and peeling camellia oil seeds, and drying at 85 ℃ for later use; crushing camellia oil seeds in a crusher to obtain crushed seed kernels; sending the crushed kernels into a hydraulic presser for pressing, wherein the pressing process parameters are as follows: feeding at 55 deg.C, squeezing at 60 deg.C under 12MPa for 20min for 3 times to obtain crude oil; and (4) delivering the mixture into a low-temperature centrifuge for high-speed centrifugation, wherein the rotating speed is 20000rpm, and taking the upper-layer grease.
In the plant compound for preventing and growing hair described above,
the preparation method of the licorice extract comprises the following steps:
drying liquorice, cutting into particles, mixing the particles with anhydrous acetone in a ratio of 1: 10, the mixing temperature is 65 ℃, standing extraction is carried out for 6 hours, centrifugation is carried out at 10000rpm for 10min, and supernate is collected and rotary evaporated to form the acetone anhydrous.
In the plant compound for preventing and growing hair described above,
the preparation method of the konjac polypeptide extract comprises the following steps:
cleaning rhizoma Amorphophalli, peeling, crushing at low temperature, stirring, adding Tris-HCl buffer solution with concentration of 0.8M and neutral protease with pH of 6.8-7.0, and ultrasonically dissolving with-20 deg.C freeze-drying after centrifuging (5000 rpm).
The preparation method of the plant compound for preventing alopecia and growing hair comprises the following steps:
grinding radix astragali, glossy privet fruit, cacumen biotae, prepared rehmannia root, cortex dictamni and eclipta alba into powder, wherein the particle size of the powder is 1000 meshes, and mixing the powder with deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the camellia oil extract, the liquorice extract and the konjac polypeptide extract, wherein the mixing temperature is 35 ℃.
Example 4
The anti-hair loss and hair growth promoting plant compound comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing hair described above,
the astragalus root, the glossy privet fruit, the cacumen biotae, the prepared rehmannia root, the dittany bark and the eclipta alba are purchased from Chinese traditional medicine company Limited.
In the plant compound for preventing and growing hair described above,
the preparation method of the camellia oil extract comprises the following steps:
screening, cleaning and peeling camellia oil seeds, and drying at 85 ℃ for later use; crushing camellia oil seeds in a crusher to obtain crushed seed kernels; sending the crushed kernels into a hydraulic presser for pressing, wherein the pressing process parameters are as follows: feeding at 55 deg.C, squeezing at 60 deg.C under 12MPa for 20min for 3 times to obtain crude oil; and (4) delivering the mixture into a low-temperature centrifuge for high-speed centrifugation, wherein the rotating speed is 20000rpm, and taking the upper-layer grease.
In the plant compound for preventing and growing hair described above,
the preparation method of the licorice extract comprises the following steps:
drying liquorice in the sun, cutting into particles, mixing the particles with anhydrous acetone in a proportion of 1: 10, the mixing temperature is 65 ℃, standing extraction is carried out for 6 hours, centrifugation is carried out at 10000rpm for 10min, and supernate is collected and rotary evaporated to form the acetone anhydrous.
In the plant compound for preventing and growing hair described above,
the preparation method of the konjac polypeptide extract comprises the following steps:
cleaning rhizoma Amorphophalli, peeling, crushing at low temperature, stirring, adding Tris-HCl buffer solution with concentration of 0.8M and neutral protease with pH of 6.8-7.0, ultrasonically dissolving, centrifuging (5000rpm), collecting supernatant, and freeze drying at-20 deg.C.
The preparation method of the plant compound for preventing alopecia and growing hair comprises the following steps:
grinding radix astragali, glossy privet fruit, cacumen biotae, prepared rehmannia root, cortex dictamni and eclipta alba into powder, wherein the particle size of the powder is 1000 meshes, and mixing the powder with deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the camellia oil extract, the liquorice extract and the konjac polypeptide extract, wherein the mixing temperature is 35 ℃.
Example 5
The anti-hair loss and hair growth promoting plant compound comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing the hair,
the astragalus root, the glossy privet fruit, the cacumen biotae, the prepared rehmannia root, the dittany bark and the eclipta alba are purchased from Chinese traditional medicine company Limited.
In the plant compound for preventing and growing hair described above,
the preparation method of the camellia oil extract comprises the following steps:
screening, cleaning and peeling camellia oil seeds, and drying at 85 ℃ for later use; crushing camellia oil seeds in a crusher to obtain crushed seed kernels; sending the crushed kernels into a hydraulic presser for pressing, wherein the pressing process parameters are as follows: feeding at 55 deg.C, squeezing at 60 deg.C under 12MPa for 20min for 3 times to obtain crude oil; and (4) delivering the mixture into a low-temperature centrifuge for high-speed centrifugation, wherein the rotating speed is 20000rpm, and taking the upper-layer grease.
In the plant compound for preventing and growing hair described above,
the preparation method of the licorice extract comprises the following steps:
drying liquorice, cutting into particles, mixing the particles with anhydrous acetone in a ratio of 1: 10, the mixing temperature is 65 ℃, standing extraction is carried out for 6 hours, centrifugation is carried out at 10000rpm for 10min, and supernate is collected and rotary evaporated to form the acetone anhydrous.
In the plant compound for preventing and growing hair described above,
the preparation method of the konjac polypeptide extract comprises the following steps:
cleaning rhizoma Amorphophalli, peeling, crushing at low temperature, stirring, adding Tris-HCl buffer solution with concentration of 0.8M and neutral protease with pH of 6.8-7.0, and ultrasonically dissolving with-20 deg.C freeze-drying after centrifuging (5000 rpm).
The preparation method of the plant compound for preventing alopecia and growing hair comprises the following steps:
grinding radix astragali, glossy privet fruit, cacumen biotae, prepared rehmannia root, cortex dictamni and eclipta alba into powder, wherein the particle size of the powder is 1000 meshes, and mixing the powder with deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the camellia oil extract, the liquorice extract and the konjac polypeptide extract, wherein the mixing temperature is 35 ℃.
Comparative example 1
The anti-hair loss and hair growth promoting plant compound comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing hair described above,
the astragalus root, the glossy privet fruit, the cacumen biotae, the prepared rehmannia root, the dittany bark and the eclipta alba are purchased from Chinese traditional medicine company Limited.
In the plant compound for preventing and growing hair described above,
the preparation method of the licorice extract comprises the following steps:
drying liquorice, cutting into particles, mixing the particles with anhydrous acetone in a ratio of 1: 10, the mixing temperature is 65 ℃, standing extraction is carried out for 6 hours, centrifugation is carried out at 10000rpm for 10min, and supernate is collected and rotary evaporated to form the acetone anhydrous.
In the plant compound for preventing and growing hair described above,
the preparation method of the konjac polypeptide extract comprises the following steps:
cleaning rhizoma Amorphophalli, peeling, crushing at low temperature, stirring, adding Tris-HCl buffer solution with concentration of 0.8M and neutral protease with pH of 6.8-7.0, and ultrasonically dissolving with-20 deg.C freeze-drying after centrifuging (5000 rpm).
The preparation method of the plant compound for preventing alopecia and growing hair comprises the following steps:
grinding radix astragali, glossy privet fruit, cacumen biotae, prepared rehmannia root, cortex dictamni and eclipta alba into powder, wherein the particle size of the powder is 1000 meshes, and mixing the powder with deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the liquorice extract and the konjak polypeptide extract, wherein the mixing temperature is 35 ℃.
Comparative example 2
The anti-hair loss and hair growth promoting plant compound comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing hair described above,
the astragalus root, the glossy privet fruit, the cacumen biotae, the prepared rehmannia root, the dittany bark and the eclipta alba are purchased from Chinese traditional medicine company Limited.
In the plant compound for preventing and growing hair described above,
the preparation method of the camellia oil extract comprises the following steps:
screening, cleaning and peeling camellia oil seeds, and drying at 85 ℃ for later use; crushing camellia oil seeds in a crusher to obtain crushed seed kernels; sending the crushed kernels into a hydraulic presser for pressing, wherein the pressing process parameters are as follows: feeding at 55 deg.C, barrel temperature of 60 deg.C, squeezing pressure of 12MPa, squeezing time of 20min, and squeezing times of 3 times to obtain crude oil; and (4) delivering the mixture into a low-temperature centrifuge for high-speed centrifugation, wherein the rotating speed is 20000rpm, and taking the upper-layer grease.
In the plant compound for preventing and growing hair described above,
the preparation method of the konjac polypeptide extract comprises the following steps:
cleaning rhizoma Amorphophalli, peeling, crushing at low temperature, stirring, adding Tris-HCl buffer solution with concentration of 0.8M and neutral protease with pH of 6.8-7.0, ultrasonically dissolving, centrifuging (5000rpm), collecting supernatant, and freeze drying at-20 deg.C.
The preparation method of the plant compound for preventing alopecia and growing hair comprises the following steps:
grinding radix astragali, glossy privet fruit, cacumen biotae, prepared rehmannia root, cortex dictamni and eclipta alba into powder, wherein the particle size of the powder is 1000 meshes, and mixing the powder with deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the camellia oil extract and the konjac polypeptide extract, wherein the mixing temperature is 35 ℃.
Comparative example 3
The anti-hair loss and hair growth promoting plant compound comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing hair described above,
the astragalus root, the glossy privet fruit, the cacumen biotae, the prepared rehmannia root, the dittany bark and the eclipta alba are purchased from Chinese traditional medicine company Limited.
In the plant compound for preventing and growing hair described above,
the preparation method of the camellia oil extract comprises the following steps:
screening, cleaning and peeling camellia oil seeds, and drying at 85 ℃ for later use; crushing camellia oil seeds in a crusher to obtain crushed seed kernels; sending the crushed kernels into a hydraulic presser for pressing, wherein the pressing process parameters are as follows: feeding at 55 deg.C, squeezing at 60 deg.C under 12MPa for 20min for 3 times to obtain crude oil; and (4) delivering the mixture into a low-temperature centrifugal machine for high-speed centrifugation, wherein the rotating speed is 20000rpm, and taking the upper-layer grease to obtain the high-temperature-resistant and high-speed-resistant grease.
In the plant compound for preventing and growing hair described above,
the preparation method of the licorice extract comprises the following steps:
drying liquorice, cutting into particles, mixing the particles with anhydrous acetone in a ratio of 1: 10, the mixing temperature is 65 ℃, standing extraction is carried out for 6 hours, centrifugation is carried out at 10000rpm for 10min, and supernate is collected and rotary evaporated to form the acetone anhydrous.
The preparation method of the plant compound for preventing alopecia and growing hair comprises the following steps:
grinding radix astragali, glossy privet fruit, cacumen biotae, prepared rehmannia root, cortex dictamni and eclipta alba into powder, wherein the particle size of the powder is 1000 meshes, and mixing the powder with deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the camellia oil extract and the liquorice extract, wherein the mixing temperature is 35 ℃.
Comparative example 4
The anti-hair loss and hair growth promoting plant compound comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing hair described above,
the astragalus root, the prepared rehmannia root, the cortex dictamni and the eclipta alba are purchased from Chinese traditional medicine company Limited.
In the plant compound for preventing and growing hair described above,
the preparation method of the camellia oil extract comprises the following steps:
screening, cleaning and peeling camellia oil seeds, and drying at 85 ℃ for later use; crushing camellia oil seeds in a crusher to obtain crushed seed kernels; sending the crushed kernels into a hydraulic presser for pressing, wherein the pressing process parameters are as follows: feeding at 55 deg.C, barrel temperature of 60 deg.C, squeezing pressure of 12MPa, squeezing time of 20min, and squeezing times of 3 times to obtain crude oil; and (4) delivering the mixture into a low-temperature centrifuge for high-speed centrifugation, wherein the rotating speed is 20000rpm, and taking the upper-layer grease.
In the plant compound for preventing and growing the hair,
the preparation method of the licorice extract comprises the following steps:
drying liquorice, cutting into particles, mixing the particles with anhydrous acetone in a ratio of 1: 10, the mixing temperature is 65 ℃, standing extraction is carried out for 6 hours, centrifugation is carried out at 10000rpm for 10min, and supernate is collected and rotary evaporated to form the acetone anhydrous.
In the plant compound for preventing and growing hair described above,
the preparation method of the konjac polypeptide extract comprises the following steps:
cleaning rhizoma Amorphophalli, peeling, crushing at low temperature, stirring, adding Tris-HCl buffer solution with concentration of 0.8M and neutral protease with pH of 6.8-7.0, and ultrasonically dissolving with-20 deg.C freeze-drying after centrifuging (5000 rpm).
The preparation method of the plant compound for preventing hair loss and growing hair comprises the following steps:
grinding radix astragali, radix rehmanniae Preparata, cortex Dictamni Radicis and Ecliptae herba into powder, wherein the particle size of the powder is 1000 meshes, and mixing the powder with deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the camellia oil extract, the liquorice extract and the konjac polypeptide extract, wherein the mixing temperature is 35 ℃.
Comparative example 5
The anti-hair loss and hair growth promoting plant compound comprises the following raw materials in percentage by weight:
in the plant compound for preventing and growing hair described above,
the astragalus root, the glossy privet fruit, the cacumen biotae and the eclipta alba are purchased from Chinese traditional medicine limited company.
In the plant compound for preventing and growing hair described above,
the preparation method of the camellia oil extract comprises the following steps:
screening, cleaning and peeling camellia oil seeds, and drying at 85 ℃ for later use; crushing camellia oil seeds in a crusher to obtain crushed seed kernels; sending the crushed kernels into a hydraulic presser for pressing, wherein the pressing process parameters are as follows: feeding at 55 deg.C, squeezing at 60 deg.C under 12MPa for 20min for 3 times to obtain crude oil; and (4) delivering the mixture into a low-temperature centrifuge for high-speed centrifugation, wherein the rotating speed is 20000rpm, and taking the upper-layer grease.
In the plant compound for preventing and growing hair described above,
the preparation method of the licorice extract comprises the following steps:
drying liquorice, cutting into particles, mixing the particles with anhydrous acetone in a ratio of 1: 10, the mixing temperature is 65 ℃, standing extraction is carried out for 6 hours, centrifugation is carried out at 10000rpm for 10min, and supernate is collected and rotary evaporated to form the acetone anhydrous.
In the plant compound for preventing and growing hair described above,
the preparation method of the konjac polypeptide extract comprises the following steps:
cleaning rhizoma Amorphophalli, peeling, crushing at low temperature, stirring, adding Tris-HCl buffer solution with concentration of 0.8M and neutral protease with pH of 6.8-7.0, and ultrasonically dissolving with-20 deg.C freeze-drying after centrifuging (5000 rpm).
The preparation method of the plant compound for preventing hair loss and growing hair comprises the following steps:
grinding radix astragali, fructus ligustri lucidi, cacumen biotae and herba ecliptae into powder, mixing the powder and deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the camellia oil extract, the liquorice extract and the konjac polypeptide extract, wherein the mixing temperature is 35 ℃.
The test scheme is as follows:
200 alopecia areata groups of 30-55 years of age are selected, wherein 120 male people and 80 female people are selected. Trial objects with similar symptoms are distributed into each group as evenly as possible, and the proportion of male and female is distributed as evenly as possible.
(1) Alopecia preventing and hair growing ability
Before trial, the hair growth condition of a user (20 persons in each group on average and the hair density is close) is photographed, then the hair growth condition of the user is photographed by a camera every month, and finally the average value of each group is taken. The test method comprises the following steps: it is administered 1 g/time in the morning and evening each day. During the test period, subjects were protected from excessive uv exposure, and during the test period, products other than the test samples, etc. were not used for 180 days.
Table 1 hair Density test results
As seen from Table 1, the products prepared in examples 1 to 5 designed in this application have superior alopecia preventing and hair growing effects compared to those of comparative examples 1 to 5, and the hair density of the hair can be as high as 75.7% by six months of use, and the amount of use is only 1 g/time. The three extracts (camellia oil extract, liquorice extract and konjac polypeptide extract) play a key role, and are mutually synergistic with other active substances to improve the blood circulation of the scalp, mainly increase and form the capillaries around the hair follicle, provide sufficient nutrition for the hair, improve the activity of the hair follicle, and simultaneously can improve the activity of hair papilla cells so as to prevent pore blockage caused by vigorous oil secretion, accelerate alopecia, and promote new hair growth by active ingredients permeating into the hair follicle. Therefore, the hair loss can be effectively prevented, the hair growth can be promoted, and the scalp allergy can not be caused. The preparation method is simple and convenient, and is convenient for large-scale production.
(2) Ability to blacken hair
Example 5, which is the best to prevent hair loss, was tested as follows:
the using method comprises the following steps: cleaning hair, uniformly smearing 5g of product from hair tail to hair root, gently massaging until hair root, standing for 5min, wrapping hair with bath cap or hot towel, standing for 20min, and washing with warm water. It is used 1 time every 3 days.
Clinical experiments are carried out, the product prepared in the embodiment 5 of the invention has good effect after being used for 7 days, the hair quality is gradually blackish and bright and soft and smooth after being continuously used for 15 days, and scurf, hair oil and head itch are greatly reduced after 1 month, and the hair quality is bright, glossy and rich in elasticity.
While the invention has been described in further detail with reference to specific embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (8)
4. the anti-alopecia, hair-growing plant compound of claim 1, wherein:
the astragalus root, the glossy privet fruit, the cacumen biotae, the prepared rehmannia root, the dittany bark and the eclipta alba are purchased from Chinese traditional medicine company Limited.
5. The anti-alopecia, hair-growing plant compound according to claim 1, wherein:
the preparation method of the camellia oil extract comprises the following steps:
screening, cleaning and peeling camellia oil seeds, and drying at 85 ℃ for later use; crushing camellia oil seeds in a crusher to obtain crushed seed kernels; sending the crushed kernels into a hydraulic presser for pressing, wherein the pressing process parameters are as follows: feeding at 55 deg.C, squeezing at 60 deg.C under 12MPa for 20min for 3 times to obtain crude oil; and (4) delivering the mixture into a low-temperature centrifuge for high-speed centrifugation, wherein the rotating speed is 20000rpm, and taking the upper-layer grease.
6. The anti-alopecia, hair-growing plant compound of claim 1, wherein:
the preparation method of the licorice extract comprises the following steps:
drying liquorice, cutting into particles, mixing the particles with anhydrous acetone in a ratio of 1: 10, the mixing temperature is 65 ℃, standing extraction is carried out for 6 hours, centrifugation is carried out at 10000rpm for 10min, and supernate is collected and rotary evaporated to form the acetone anhydrous.
7. The anti-alopecia, hair-growing plant compound according to claim 1, wherein:
the preparation method of the konjac polypeptide extract comprises the following steps:
cleaning and peeling konjak, crushing and stirring at low temperature, adding Tris-HCl buffer solution and neutral protease for ultrasonic-assisted dissolution, wherein the concentration of the Tris-HCl buffer solution is 0.8M, the pH value of the Tris-HCl buffer solution is 6.8-7.0, centrifuging, taking supernatant, and freeze-drying to obtain the konjak.
8. A preparation method of a plant compound for preventing hair loss and growing hair is characterized in that:
the method comprises the following steps:
grinding radix astragali, glossy privet fruit, cacumen biotae, prepared rehmannia root, cortex dictamni and eclipta alba into powder, wherein the particle size of the powder is 1000 meshes, and mixing the powder with deionized water, wherein the mass ratio of the powder to the deionized water is 1: 50, obtaining a serous fluid, and finally mixing the serous fluid with the camellia oil extract, the liquorice extract and the konjac polypeptide extract.
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