CN111265622A - Anti-hair loss, anti-white hair and hair moistening traditional Chinese medicine extract - Google Patents
Anti-hair loss, anti-white hair and hair moistening traditional Chinese medicine extract Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine extract for preventing alopecia, preventing white hair and moistening hair, and relates to the technical field of medicinal preparations. The technical key points are as follows: the anti-hair loss, anti-white hair and hair nourishing traditional Chinese medicine extract comprises the following components in parts by weight: gastrodia elata: 25-50 parts; and (3) preparing the cattle paint: 25-50 parts; dodder seed: 50-100 parts; polygonum multiflorum: 150-200 parts; wolfberry fruit: 50-100 parts; tuckahoe, poria cocos: 50-80 parts; chinese angelica: 100-120 parts; amaranth seed: 10-20 parts; and (3) eclipta: 100-120 parts; cacumen biotae: 130-140 parts; chinese prickly ash: 5-10 parts; licorice root: 25-50 parts; ligusticum wallichii: 10-20 parts, and the traditional Chinese medicine extract prepared by the formula has the effects of growing hair, blackening hair and moistening hair and has obvious curative effect.
Description
Technical Field
The invention relates to the technical field of medicinal preparations, in particular to a Chinese medicinal extract for preventing alopecia, preventing white hair and moistening hair.
Background
The clinical common alopecia comprises alopecia areata and seborrheic alopecia, wherein the alopecia areata is also called round alopecia, the traditional Chinese medicine is called oily wind and ghost shaving head, the alopecia is a sudden alopecia, the alopecia is flaky in a light person, the alopecia is completely alopecia or general alopecia in a heavy person, and the pathogenesis is considered to be related to autoimmune condition, heredity and mental factors. Seborrheic alopecia is commonly seen in young and strong males, is a common disease and frequently encountered disease in dermatology, is mainly manifested as progressive alopecia in the forehead and top of the head, has complex causes, and is generally considered to be related to genetic susceptibility and metabolic abnormality of androgen local to scalp hair follicles.
At present, western medicines have no specific treatment method for alopecia, but Chinese traditional medicine has unique understanding and methods for pathogenesis and treatment of alopecia, and obtains better curative effect in practice. The traditional Chinese medicine considers that: alopecia is related to the liver, kidney, spleen and qi and blood in the five internal organs of the human body. The hair is rich in blood, and the hair is not nourished without sufficient blood; the liver stores blood and mainly disperses qi, qi movement is not smooth when liver qi fails to disperse qi, skin can not be nourished by blood along with qi, and pores are relaxed and fall; kidneys govern bones, which are in the hair; the spleen governs transportation and transformation, and transports food essence upwards to the heart and lung to transform it into vital material such as qi and blood. Therefore, any change in their function can lead to hair loss. Therefore, the therapeutic principle of traditional Chinese medicine is as follows: the yin and yang of the human body are balanced by regulating various body organs such as the liver, the kidney, the spleen and the like on the whole, and the function of treating the alopecia is played on the whole by fully utilizing the four-qi and five-flavor, the efficacy indication and the compatibility principle of the traditional Chinese medicine.
The applicant of the present invention has found in the actual research process that the above technical solutions have the problem of rationality of prescription formulation, for example, if the prescription composition ratio such as "bupleurum root is used to replace starwort root, or poria cocos is replaced with grifola" can produce the same or similar therapeutic effect, and the applicant has made a great deal of research aiming at the above technical solutions and found that the prescription disclosed by the applicant has irrational.
Therefore, a new solution is needed to solve the above problems.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide the anti-hair loss, anti-white hair and hair moistening traditional Chinese medicine extract which has the advantages of obvious curative effect and controllable quality.
In order to achieve the purpose, the invention provides the following technical scheme:
a traditional Chinese medicine extract for preventing alopecia, preventing white hair and moistening hair comprises the following components in parts by weight:
gastrodia elata: 25-50 parts;
and (3) preparing the cattle paint: 25-50 parts;
dodder seed: 50-100 parts;
polygonum multiflorum: 150-200 parts;
wolfberry fruit: 50-100 parts;
tuckahoe, poria cocos: 50-80 parts;
chinese angelica: 100-120 parts;
amaranth seed: 10-20 parts;
and (3) eclipta: 100-120 parts;
cacumen biotae: 130-140 parts;
chinese prickly ash: 5-10 parts;
licorice root: 25-50 parts;
ligusticum wallichii: 10-20 parts.
By adopting the technical scheme, the traditional Chinese medicine extract disclosed by the invention takes the gastrodia elata, the achyranthes bidentata and the polygonum multiflorum as monarch drugs in a formula, and is prepared according to the basic knowledge of traditional Chinese medicine: the hair is nourished from blood, rooted in kidney qi, and kidney governs bones, which nourish hair, so the growth and shedding of hair are closely related to the abundance or decline of kidney essence, liver blood storage and its function of smoothing flow of qi; therefore, the two cooperate to play the functions of nourishing liver and kidney, benefiting essence and blood, blacking beard and growing hair; and the medicinal materials such as the dodder, the medlar, the tuckahoe, the angelica and the like are taken as ministerial drugs to improve the functions of tonifying qi and blood and strengthening liver and kidney of the monarch drugs, and the monarch drugs and the ministerial drugs supplement each other to remarkably enhance the motive power of nourishing liver and kidney, strengthening qi and blood, growing hair and blackening hair. The Chinese angelica, the amaranth, the eclipta, the cacumen biotae, the pepper and other medicines are added in the prescription to nourish yin and clear heat to promote the balance of yin and yang of the organism, and effectively improve the symptoms of attack of wind evil on the human body due to deficiency, exuberance of wind, blood dryness or mental stimulation, dysphoria of mood, hyperactivity of heart fire and wind generation due to blood heat; finally, the Chinese arborvitae twig and the yerbadetajo herb are used for nourishing yin and growing hair. The whole formula is comprehensively viewed, multiple medicinal materials are simplified and matched with each other, the yin balance and the yang balance of the organism of a patient with the disease are commonly conditioned, and the effects of growing, blackening and moistening the hair are finally exerted integrally.
Preferably, the anti-hair-loss, anti-white hair and hair-moistening traditional Chinese medicine extract comprises the following components in parts by weight:
gastrodia elata: 37 parts of;
and (3) preparing the cattle paint: 37 parts of;
dodder seed: 75 parts of a mixture;
polygonum multiflorum: 175 parts of a lubricant;
wolfberry fruit: 75 parts of a mixture;
tuckahoe, poria cocos: 65 parts of (1);
chinese angelica: 110 parts of (A);
amaranth seed: 15 parts of (1);
and (3) eclipta: 110 parts of (A);
cacumen biotae: 135 parts of (A);
chinese prickly ash: 7 parts;
licorice root: 35 parts of (B);
ligusticum wallichii: 15 parts.
Further preferably, the traditional Chinese medicine extract is prepared by the following steps:
s1, respectively pulverizing radix Polygoni Multiflori, fructus Zanthoxyli and fructus Lycii into fine powder for use;
s2, pulverizing 1/3 amounts of rhizoma Ligustici Chuanxiong, folium Platycladi, Poria, semen Amaranthi Tricoloris, and Glycyrrhrizae radix into fine powder for use;
s3, mixing the rest of ligusticum wallichii, cacumen biotae, poria cocos, amaranth seeds and liquorice with the raw materials of eclipta, gastrodia elata and achyranthes bidentata, adding water with the weight ratio of 6-12 times of the raw materials and the pH value of 3.0-8.0, soaking for 20-60min, heating and decocting for 3 times, wherein the water is 0.5-2h for each time, combining decoction, filtering, concentrating the filtrate at 50-60 ℃ until the relative density is 1.1-1.5, adding all the ligusticum wallichii and poria cocos fine powder in the step S2 and the 1/2 polygonum multiflorum fine powder in the step S1, uniformly mixing, drying at 60-80 ℃, and crushing into fine powder for later use;
s4, adding water with the weight ratio of 6-12 times of that of the raw materials and the pH value of 3.0-8.0 into semen cuscutae and angelica sinensis, soaking for 20-60min, heating and decocting for 3 times, each time for 0.5-2h, merging decoction, filtering, concentrating filtrate at 50-70 ℃ until the relative density is 1.1-1.5, cooling to 30-40 ℃, adding ethanol to ensure that the ethanol content reaches 70-90%, refrigerating and standing for 24-48h, filtering and recovering ethanol, concentrating filtrate at 50-60 ℃ until the relative density is 1.1-1.5, adding the remaining polygonum multiflorum fine powder in the step S1, mixing uniformly, drying at 60-80 ℃, and crushing into fine powder for later use;
s5, mixing the fine powders of fructus Zanthoxyli and fructus Lycii in step S1, the fine powders of folium Platycladi, semen Amaranthi Tricoloris and radix Glycyrrhizae in step S2, and the fine powders remained in steps S3 and S4, and pulverizing.
By adopting the technical scheme, in the research process of the preparation method of the traditional Chinese medicine extract, the conventional extraction methods such as alcohol extraction, percolation, immersion, water extraction and the like are respectively explored for different medicines, the parameter range of semi-bionic extraction in the technical scheme is occasionally and creatively explored, and the technical effect is particularly outstanding. The semi-bionic method is a new medicine extraction technology in modern pharmacy, has the characteristics of conforming to the process of transporting medicines through gastrointestinal tracts, being suitable for industrial production and embodying the comprehensive component action of the traditional Chinese medicine, and is not equal to the 'acid-base method' in a pure chemical viewpoint. The most central technical point of the method is that the active mixture of the medicines which are suitable for the gastrointestinal absorption of the human body is extracted, which is in accordance with the guiding idea of the traditional Chinese medicine that the curative effect is exerted integrally and uniformly.
More preferably, in step S5, the fine powder is mixed and pulverized to have a particle size of less than 75 μm.
By adopting the technical scheme, the mixed fine powder is continuously subjected to superfine grinding, so that after the main extract acts on a human body, the active substances of the main extract are more easily distributed and absorbed by the human body, and the main extract can quickly take effect.
Further preferably, the anti-hair-loss, anti-white hair and hair-moistening traditional Chinese medicine extract can be prepared into any acceptable dosage form of a traditional Chinese medicine preparation.
More preferably, the dosage form is powder, pill or capsule.
In summary, compared with the prior art, the invention has the following beneficial effects:
(1) through multiple experimental researches, the 13 medicinal materials are simplified, matched and mutually matched, so that the yin-yang balance of a body of a patient with the disease is conditioned together, and the effects of growing hair, blackening hair and moistening hair are exerted integrally;
(2) based on a formula system of the traditional Chinese medicine extract, the invention also provides a semi-bionic extraction method, a proper parameter range is determined through repeated exploration, and the application effect is more prominent, so that the obtained product not only can be used for compounding the process of transporting the medicine through the gastrointestinal tract, but also is suitable for industrial production, and has controllable quality;
(3) the traditional Chinese medicine extract prepared by the invention is subjected to final crushing treatment, so that the particle size of the traditional Chinese medicine extract is controlled to be less than 75 micrometers, and after the main extract acts on a human body, effective substances of the main extract are more easily distributed and absorbed by the human body and can quickly take effect.
Detailed Description
The present invention will be described in detail with reference to examples.
Example 1: the anti-hair-loss, anti-white hair and hair-moistening traditional Chinese medicine extract comprises the following components in parts by weight as shown in table 1:
s1, respectively pulverizing radix Polygoni Multiflori, fructus Zanthoxyli and fructus Lycii into fine powder for use;
s2, pulverizing 1/3 amounts of rhizoma Ligustici Chuanxiong, folium Platycladi, Poria, semen Amaranthi Tricoloris, and Glycyrrhrizae radix into fine powder for use;
s3, mixing the rest of the ligusticum wallichii, the cacumen biotae, the poria cocos, the amaranth and the liquorice with the raw materials of the eclipta, the gastrodia elata and the achyranthes bidentata, adding water with the weight ratio of 6 times and the pH value of 3.0, soaking for 20min, heating and decocting for 3 times, wherein each time lasts for 0.5h, combining decoction solutions, filtering, concentrating filtrate at 50 ℃ until the relative density is 1.1, adding all the ligusticum wallichii and poria cocos fine powder in the step S2 and the 1/2 polygonum multiflorum fine powder in the step S1, uniformly mixing, drying at 60 ℃, and crushing into fine powder for later use;
s4, adding water with the weight ratio of 6 times of that of the raw materials and the pH value of 3.0 into semen cuscutae and angelica sinensis, soaking for 20min, heating and decocting for 3 times, each time for 0.5h, merging decoction, filtering, concentrating the filtrate at 50 ℃ until the relative density is 1.1, adding ethanol when cooling to 30 ℃, refrigerating and standing for 48h, filtering and recovering the ethanol, concentrating the filtrate at 50 ℃ until the relative density is 1.1, adding the remaining polygonum multiflorum fine powder in the step S1, mixing uniformly, drying at 60 ℃ and crushing into fine powder for later use;
s5, mixing the fine powder of fructus Zanthoxyli and fructus Lycii in step S1, the fine powder of folium Platycladi, semen Amaranthi Tricoloris and radix Glycyrrhizae in step S2 and the fine powder remained in steps S3 and S4, and pulverizing into powder with particle size of 60-70 μm.
Examples 2 to 6: the difference between the extract of the traditional Chinese medicine for preventing alopecia and preventing white hair and moistening hair and the example 1 is that the components and the corresponding parts by weight are shown in the table 1.
TABLE 1 Components and parts by weight of examples 1-6
Example 7: the traditional Chinese medicine extract for preventing alopecia, preventing white hair and moistening hair is different from the extract prepared in example 1 in specific preparation parameters and comprises the following specific steps:
s1, respectively pulverizing radix Polygoni Multiflori, fructus Zanthoxyli and fructus Lycii into fine powder for use;
s2, pulverizing 1/3 amounts of rhizoma Ligustici Chuanxiong, folium Platycladi, Poria, semen Amaranthi Tricoloris, and Glycyrrhrizae radix into fine powder for use;
s3, mixing the rest of the ligusticum wallichii, the cacumen biotae, the poria cocos, the amaranth and the liquorice with the raw materials of the eclipta, the gastrodia elata and the achyranthes bidentata, adding water with the weight ratio of 12 times and the pH value of 8.0, soaking for 60min, heating and decocting for 3 times, mixing the decoction liquid for 2h each time, filtering, concentrating the filtrate at 60 ℃ until the relative density is 1.5, adding all the ligusticum wallichii and poria cocos fine powder in the step S2 and the 1/2 polygonum multiflorum fine powder in the step S1, uniformly mixing, drying at 80 ℃ and crushing into fine powder for later use;
s4, adding water with the weight ratio of 12 times of that of the raw materials and the pH value of 8.0 into semen cuscutae and angelica sinensis, soaking for 60min, heating and decocting for 3 times, 2h each time, merging decoction, filtering, concentrating the filtrate at 70 ℃ until the relative density is 1.5, cooling to 40 ℃, adding ethanol until the alcohol content reaches 90%, refrigerating and standing for 24h, filtering and recovering the ethanol, concentrating the filtrate at 60 ℃ until the relative density is 1.5, adding the remaining polygonum multiflorum fine powder in the step S1, mixing uniformly, drying at 80 ℃, and crushing into fine powder for later use;
s5, mixing the fine powder of fructus Zanthoxyli and fructus Lycii in step S1, the fine powder of folium Platycladi, semen Amaranthi Tricoloris and radix Glycyrrhizae in step S2 and the fine powder remained in steps S3 and S4, and pulverizing into powder with particle size of 60-70 μm.
Comparative example 1: the difference from example 1 is that the formulation disclosed in example 1 of the invention patent with patent number ZL01130604.1 is adopted and the preparation method of example 1 in the invention is utilized for preparation.
Comparative example 2: the difference from example 1 was that a general commercially available hair growth capsule was used as comparative example 2.
Performance testing
The traditional Chinese medicine extracts obtained in examples 1-7 and comparative example 1 are respectively mixed with pharmaceutically common auxiliary materials, and the mixture is encapsulated to be used as a test sample. Wherein the common adjuvants are starch and lactose, and the capsule is gelatin capsule.
450 typical alopecia patients were selected as test subjects, and the patients were aged between 30-55 years and the disease course was 1-5 years, and were randomly divided into 9 groups of 50 patients. Each group of patients orally took the capsules prepared in examples 1 to 7 and comparative examples 1 to 2, respectively, 2 times a day, 3 capsules at a time, and the effect was observed after 3 months of continuous administration.
The test results are divided into four grades:
the skin injury is healed to have new hair growth or final hair growth, the distribution density, the hair thickness and the color are similar to those of normal hair, and the beautifying effect is achieved.
The effect is that the area covered by the terminal hair is more than 1/2 bald hair areas, and more of the terminal hair becomes terminal hair, which is seen to be sparse, long and firm.
Effective is that new hair growth is more than 10 percent, and includes the growth of thin, short and pale vellus hairs, but the growth is slow, the vellus hairs are not completely recovered, and the vellus hairs are not grown finally.
The ineffectiveness is no or only a small amount of vellus hair growth or continued alopecia after 1-2 treatment courses.
The total clinical effective rate is calculated by the sum of cure, obvious effect and effective cases, and the test results are shown in Table 2.
As can be seen from the test data in Table 2, the number and color of hairs of most patients in examples 1-7 are significantly improved after taking the capsule for three months, and the total effective rate is more than 86%, while the effective rate is only 40% in comparative example 1 and 56% in comparative example 2. The test result shows that the traditional Chinese medicine extract prepared by the technical scheme of the invention has outstanding effect on treating alopecia, and the curative effect is far greater than that of common medicines sold on the market.
Table 2 results of performance testing
| Group of | Show effect | Is effective | Invalidation | Overall efficiency |
| Example 1 | 17 | 28 | 5 | 90％ |
| Example 2 | 17 | 27 | 6 | 88％ |
| Example 3 | 18 | 26 | 6 | 88％ |
| Example 4 | 17 | 28 | 5 | 90％ |
| Example 5 | 17 | 26 | 7 | 86％ |
| Example 6 | 18 | 27 | 5 | 90％ |
| Example 7 | 16 | 28 | 6 | 88％ |
| Comparative example 1 | 9 | 11 | 30 | 40％ |
| Comparative example 2 | 10 | 14 | 26 | 56％ |
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (6)
1. The anti-hair loss, anti-white hair and hair nourishing traditional Chinese medicine extract is characterized by comprising the following components in parts by weight:
gastrodia elata: 25-50 parts;
and (3) preparing the cattle paint: 25-50 parts;
dodder seed: 50-100 parts;
polygonum multiflorum: 150-200 parts;
wolfberry fruit: 50-100 parts;
tuckahoe, poria cocos: 50-80 parts;
chinese angelica: 100-120 parts;
amaranth seed: 10-20 parts;
and (3) eclipta: 100-120 parts;
cacumen biotae: 130-140 parts;
chinese prickly ash: 5-10 parts;
licorice root: 25-50 parts;
ligusticum wallichii: 10-20 parts.
2. The anti-hair-loss and anti-leukotrichia-moistening traditional Chinese medicine extract as claimed in claim 1, wherein the anti-hair-loss and anti-leukotrichia-moistening traditional Chinese medicine extract comprises the following components in parts by weight:
gastrodia elata: 37 parts of;
and (3) preparing the cattle paint: 37 parts of;
dodder seed: 75 parts of a mixture;
polygonum multiflorum: 175 parts of a lubricant;
wolfberry fruit: 75 parts of a mixture;
tuckahoe, poria cocos: 65 parts of (1);
chinese angelica: 110 parts of (A);
amaranth seed: 15 parts of (1);
and (3) eclipta: 110 parts of (A);
cacumen biotae: 135 parts of (A);
chinese prickly ash: 7 parts;
licorice root: 35 parts of (B);
ligusticum wallichii: 15 parts.
3. The traditional Chinese medicine extract for preventing alopecia, preventing white hair and moistening hair according to claim 1, which is prepared by the following steps:
s1, respectively pulverizing radix Polygoni Multiflori, fructus Zanthoxyli and fructus Lycii into fine powder for use;
s2, pulverizing 1/3 amounts of rhizoma Ligustici Chuanxiong, folium Platycladi, Poria, semen Amaranthi Tricoloris, and Glycyrrhrizae radix into fine powder for use;
s3, mixing the rest of ligusticum wallichii, cacumen biotae, poria cocos, amaranth seeds and liquorice with the raw materials of eclipta, gastrodia elata and achyranthes bidentata, adding water with the weight ratio of 6-12 times of the raw materials and the pH value of 3.0-8.0, soaking for 20-60min, heating and decocting for 3 times, wherein the water is 0.5-2h for each time, combining decoction, filtering, concentrating the filtrate at 50-60 ℃ until the relative density is 1.1-1.5, adding all the ligusticum wallichii and poria cocos fine powder in the step S2 and the 1/2 polygonum multiflorum fine powder in the step S1, uniformly mixing, drying at 60-80 ℃, and crushing into fine powder for later use;
s4, adding water with the weight ratio of 6-12 times of that of the raw materials and the pH value of 3.0-8.0 into semen cuscutae and angelica sinensis, soaking for 20-60min, heating and decocting for 3 times, each time for 0.5-2h, merging decoction, filtering, concentrating filtrate at 50-70 ℃ until the relative density is 1.1-1.5, cooling to 30-40 ℃, adding ethanol to ensure that the ethanol content reaches 70-90%, refrigerating and standing for 24-48h, filtering and recovering ethanol, concentrating filtrate at 50-60 ℃ until the relative density is 1.1-1.5, adding the remaining polygonum multiflorum fine powder in the step S1, mixing uniformly, drying at 60-80 ℃, and crushing into fine powder for later use;
s5, mixing the fine powders of fructus Zanthoxyli and fructus Lycii in step S1, the fine powders of folium Platycladi, semen Amaranthi Tricoloris and radix Glycyrrhizae in step S2, and the fine powders remained in steps S3 and S4, and pulverizing.
4. The extract of the traditional Chinese medicine for preventing hair loss, preventing white hair and moistening hair of claim 3, wherein in step S5, the particle size of the mixed and pulverized fine powder is less than 75 μm.
5. The extract of the traditional Chinese medicine for preventing alopecia and preventing poliosis and moistening hair according to any one of claims 1 to 4, wherein the extract of the traditional Chinese medicine for preventing alopecia and preventing poliosis and moistening hair can be prepared into any dosage form acceptable by a traditional Chinese medicine preparation.
6. The anti-hair-loss anti-poliosis hair-moistening traditional Chinese medicine extract as claimed in claim 5, wherein the dosage form is powder, pill or capsule.
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| US20230372222A1 (en) * | 2022-05-17 | 2023-11-23 | Two Lines Inc., dba Arey Grey | Formulations and methods for treating hair |
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