CN1582985A - Medicine for diabetes and its preparation - Google Patents
Medicine for diabetes and its preparation Download PDFInfo
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- CN1582985A CN1582985A CN 200410006544 CN200410006544A CN1582985A CN 1582985 A CN1582985 A CN 1582985A CN 200410006544 CN200410006544 CN 200410006544 CN 200410006544 A CN200410006544 A CN 200410006544A CN 1582985 A CN1582985 A CN 1582985A
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Abstract
A Chinese medicine in the form of capsule for treating diabetes is prepared from 24 Chinese-medicinal materials including saffron, honeysuckle flower, wolfberry fruit, rehmannia root, etc.
Description
The present invention relates to a kind of Chinese herbal medicine for the treatment of diabetes and preparation method thereof.
Technical background
Diabetes be a kind of be the incretion metabolism disease of main performance with the carbohydrate metabolism disturbance.Prevalence is higher, can cause many severe complications and various infection simultaneously.Diabetes treatment by western medicine adopts insulin, sulfonylurea, biguanides blood sugar lowering etc. more.The former need adopt the hypodermic injection treatment, life-time service, and not only patient agonizes, and easily produces toleration.Though biguanides is an oral formulations, toxicity is more.Use at present the more sulfonylurea oral hypoglycemic that is.Tolbutamide is preferable, but untoward reaction such as this class medicine still exists epigastric discomfort, inappetence, feels sick, stomachache, diarrhoea, yellow pox and liver injury can appear in a few patients, and idol has anaphylaxis.
Goal of the invention
The object of the present invention is to provide a kind of toxic and side effects few, the Chinese prescription that therapeutic effect is good, and its preparation method is provided.
Chinese prescription of the present invention is:
The celestial glossy ganoderma 30-50 of the white stiff cocoon 10-20 radix salviae miltiorrhizae 20-25 structure Chinese holly 20-25 dried rhizome of rehmannia 10-30 of safflower 10-20 fleabane flower 10-20 honeysuckle 10-20 hops 3-10 honeybee camellia 20-50 root of Chinese trichosanthes 10-50 rheum officinale 20-25 flower of Radix Puerariae 10-25 Ramulus euonymi 15-20 Fructus Corni 30 Radix Rhodiolae 10-20 radix polygonati officinalis 10-25 HERBA DENDROBII 10-20 Ligusticum wallichii 10-25 RHIIZOMA DIOSCOREAE from Henan of China 10-25 Poria cocos 10-20 Semen Nelumbinis 10-20 root bark of Chinese wolf-berry 10-30 tuber of dwarf lilyturf 10-20
Summary of the invention
Capsule preparation method thereof of the present invention is:
After getting prescription Chinese crude drug washing with water, steam sterilization half an hour, 70 ℃ of oven dry are pulverized and are also crossed per 0.155 square centimeter of 150 hole sizer.
Get all the other medical materials in the prescription, extracting in water twice, the time was respectively 2 hours, 1 hour, and amount of water is respectively 7 times, 5 times, twice extract merged, filters, be evaporated to relative density and be 1.30-1.35 (85 ℃ time survey), put coldly, adds 3 times and measure ethanol, the limit edged stirs, left standstill 24 hours, and drew supernatant (precipitate discards), decompression recycling ethanol is to the clear paste of relative density 1.30-1.35 (35 ℃ time survey).
With medicated powder and ointment mixing, at 70 ℃ of following drying under reduced pressure, pulverized per 0.155 square centimeter of 100 hole sizer, encapsulated.
Pharmaceutical analysis: the traditional Chinese medical science thinks that the basic pathogenesis of diabetes is cloudy body fluid deficiency consumptions, scorching inclined to one side Sheng, and the deficiency of YIN be this, scorching for marking.This prescription group is by the Flos puerariae lobatae of relieving heat and thirst; Promote the production of body fluid and heat-removing, detumescence blood sugar lowering Radix Trichosanthis; Yin nourishing relieving restlessness lung moistening nourishing the stomach reverses insulin cell pathology Radix Ophiopogonis; Eliminating dampness by diuresis spleen invigorating diuresis blood sugar lowering Poria; Complement controlled atmosphere blood glucose Radix Ginseng, celestial Ganoderma; The Radix Astragali of invigorating QI to consolidate the body surface resistance; Support Jin Shenglv, the Herba Dendrobii of item; Heat-clearing and toxic substances removing improves the Radix Rhodiolae of immunity; The dehumidifying blood sugar lowering improves immunity and strengthens metabolic function, Radix Rhodiolae, the Radix Rehmanniae of treatment diabetes; There are the blood sugar lowering Rhizoma Atractylodis to join the Radix Scrophulariae blood sugar lowering; The effect that prolongs the blood sugar lowering time is arranged.Blood circulation promoting and blood stasis dispelling, blood stasis dispersing and fresh blood promoting, the equilibrium between yin and yang of adjusting human body changes microcirculatory Radix Puerariae, Radix Salviae Miltiorrhizae, red small cup flower, Stigma Croci, celestial Ganoderma, Radix Ginseng, Rhizoma Chuanxiong, Radix Et Caulis Acanthopanacis Senticosi; Collateral dredging is invigorated blood circulation, and living arteries and veins nourishes blood.Radix Et Rhizoma Rhei, BAIJIANG cocoon, the hypoglycemic active force of Ramulus Euonymi are strong.Rhizoma Atractylodis are in the Fructus Mume promoting the production of body fluid to quench thirst; The hypoglycemic Rhizoma Anemarrhenae; The hypoglycemic Cortex Lycii of the fire second of the three ten-day periods of the hot season purifies the blood; Huang, Rhizoma Coptidis, Flos lupuli (Flos Humuli Lupuli), Radix Glycyrrhizae that pathogenic fire purging dampness blood sugar lowering and ketoboidies sugar reductase green are faced upward preparation; The hypoglycemic Radix Puerariaes of yang invigorating etc. are formulated.Give full play to Chinese medicine, face upward the characteristic of the aspects such as equilibrium between yin and yang of preparation, regulator, hypoglycemic and thirst-relieving, blood circulation promoting and blood stasis dispelling, adjusting human body changing microcirculation, metabolism, immunity, stable state, fundamentally treat diabetes and complication.
Animal experiment:
The oral acute toxicity test of rat takes once to irritate the method for feeding administration, the result show this medicine to the acute kD50 of the per os of rat greater than 20ml/kg (3040mg/kg).The rats by intraperitoneal injection acute toxicity testing is taked the method for once abdominal cavity injection administration, and the result shows that this medicine is 11.669ml/kg (1773.688mg/kg) to rat through the abdomen acute LD 50.Rat feeds for long-term mouthful, dosage is respectively six, 12, ten octuple of clinical dosage, six months long term toxicity test results show that obvious poisoning symptom does not all appear in each dosage group rat, the hematuria routine, and blood parameters and histopathological examination are all less than obviously unusual.Therefore, this medicine had not both had acute toxicity, took for a long time not present long term toxicity yet.
Drug research: by the hyperglycemia ground experimental study of animal model that this medicine brings out chemical reagent, the result shows that this medical instrument B cell that watches for animals is not subjected to the destructive effect of alloxan.The obvious effect that alloxan diabetes rats is had blood sugar lowering.Simultaneously, can also obviously face upward increasing of its platelet aggregation of system, improve blood flow state.The blood stasis situation that this point points out this medicine can improve clinical patient has the function that prevents that diabetic complication from taking place, developing.
Clinical observation:
Luoyang City's diabetes study is used for this medicine clinical, has treated 1000 many cases diabetes patients.Total effective rate 91%.Wherein can be divided into four kinds of situations: one, the light or medical history shorter one of the state of an illness, subjective symptoms is improved, and quite a few patient 3 still can keep normal level of postprandial blood sugar after progressively withdrawing antidiabetic drug; Two, the heavier or medical history of the state of an illness can comparatively ideally be kept blood sugar level than the elder with this medicine; Three, to each stage diabetics, this medicine has played the effect that prevent diabetes complication (especially vascular complication) takes place; Four,, and multiple pathological changes there is the obvious treatment effect to existing this medicine of diabetic complication patient (especially vascular complication) not only can end its development, deterioration.
The clinical data statistical table
Time | The diabetes classification | Sex person-time | Effective percentage % | Cure rate % | Inefficiency % | Remarks | ||||
The man | The woman | The man | The woman | The man | The woman | The man | The woman | |||
Year January in January, 2000 to 2004 | 1 type | ???76 | ???103 | ??100 | ???100 | ???90.5 | ???92.3 | ???0 | ???0 | |
2 types | ???87 | ???128 | ??100 | ???100 | ???92.0 | ???93.0 | ???0 | ???0 | ||
Peripheral neuropathy | ???43 | ???49 | ??100 | ???100 | ???90.0 | ???92.0 | ???0 | ???0 | ||
Diabetic nephropathy | ???48 | ???24 | ??100 | ???100 | ???89.6 | ???91.3 | ???0 | ???0 | ||
The diabetes cerebrovascular | ???36 | ???73 | ??100 | ???100 | ???88.5 | ???89.7 | ???0 | ???0 | ||
Other | ???217 | ???298 | ??100 | ???100 | ???93.0 | ???93.9 | ???0 | ???0 | ||
Add up to | ???????1179 | ????????100 | ??????????91 | ???????0 |
Claims (2)
1, a kind of Chinese prescription for the treatment of diabetes is characterized in that being prepared from by following Chinese crude drug:
Stigma Croci 10-20 Herba Erigerontis 10-20 Flos Lonicerae 10-20 Flos lupuli (Flos Humuli Lupuli) 3-10
Honeybee Flos Camelliae Japonicae 20-50 Radix Trichosanthis 10-50 Radix Et Rhizoma Rhei 20-25 flower of Radix Puerariae 10-25
BAIJIANG cocoon 10-20 Radix Salviae Miltiorrhizae 20-25 structure Fructus Lycii 20-25 Radix Rehmanniae 10-30 celestial being
Ganoderma 30-50 Ramulus Euonymi 15-20 Fructus Corni 30 Radix Rhodiolae 10-20 Rhizoma Polygonati Odorati 10
-25 Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 10-20 Rhizoma Chuanxiong 10-25 RHIIZOMA DIOSCOREAE frOm Henan of China 10-25 Poria 10-20
Semen Nelumbinis 10-20 Cortex Lycii 10-30 Radix Ophiopogonis 10-20
2, a kind of preparation method for the treatment of the Chinese patent medicine of diabetes is characterized in that various pulverizing medicinal materials in the prescription are sieved, and high temperature sterilize incapsulates, and gets capsule.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNB2004100065445A CN100352484C (en) | 2004-03-08 | 2004-03-08 | Medicine for diabetes and its preparation |
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CNB2004100065445A CN100352484C (en) | 2004-03-08 | 2004-03-08 | Medicine for diabetes and its preparation |
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CN1582985A true CN1582985A (en) | 2005-02-23 |
CN100352484C CN100352484C (en) | 2007-12-05 |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101637257A (en) * | 2009-08-19 | 2010-02-03 | 山西广济中医糖尿病防治研究所 | Food with function of regulating blood sugar and preparation method thereof |
CN1857116B (en) * | 2005-12-20 | 2010-05-12 | 东莞广发制药有限公司 | Multifunctional health food and its preparing method and use |
CN102994344A (en) * | 2012-11-23 | 2013-03-27 | 吴江永祥酒精制造有限公司 | Ginseng-based health care wine and preparation method thereof |
CN103349751A (en) * | 2013-06-10 | 2013-10-16 | 内蒙古民族大学附属医院 | Mongolian medicine composition for treating diabetic nephropathy and preparation method thereof |
CN104173451A (en) * | 2014-09-12 | 2014-12-03 | 赵全成 | Application of natural pharmaceutical composition in blood glucose-reducing drugs and health food |
CN104171188A (en) * | 2014-08-04 | 2014-12-03 | 廖为明 | Gynura procumbens health tea |
CN104367637A (en) * | 2014-11-06 | 2015-02-25 | 华洪萍 | Traditional Chinese medicine used for treating type 2 diabetes |
CN105920095A (en) * | 2016-06-12 | 2016-09-07 | 神威药业集团有限公司 | Application of traditional Chinese medicine composition for preparing medicines for treating diabetic complications |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1061910A (en) * | 1991-11-27 | 1992-06-17 | 姚昌礼 | Process for preparing diabetes medicine-ketangping |
CN1238986A (en) * | 1999-06-24 | 1999-12-22 | 齐福东 | Health-care oral liquid for diabetes patients |
CN1127344C (en) * | 2000-03-17 | 2003-11-12 | 王申 | Oral pill for curing diabetes and its complication |
-
2004
- 2004-03-08 CN CNB2004100065445A patent/CN100352484C/en not_active Expired - Fee Related
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1857116B (en) * | 2005-12-20 | 2010-05-12 | 东莞广发制药有限公司 | Multifunctional health food and its preparing method and use |
CN101637257A (en) * | 2009-08-19 | 2010-02-03 | 山西广济中医糖尿病防治研究所 | Food with function of regulating blood sugar and preparation method thereof |
CN101637257B (en) * | 2009-08-19 | 2012-11-07 | 山西广济中医糖尿病防治研究所 | Food with function of regulating blood sugar and preparation method thereof |
CN102994344A (en) * | 2012-11-23 | 2013-03-27 | 吴江永祥酒精制造有限公司 | Ginseng-based health care wine and preparation method thereof |
CN103349751A (en) * | 2013-06-10 | 2013-10-16 | 内蒙古民族大学附属医院 | Mongolian medicine composition for treating diabetic nephropathy and preparation method thereof |
CN103349751B (en) * | 2013-06-10 | 2015-01-07 | 内蒙古民族大学附属医院 | Mongolian medicine composition for treating diabetic nephropathy and preparation method thereof |
CN104171188A (en) * | 2014-08-04 | 2014-12-03 | 廖为明 | Gynura procumbens health tea |
CN104171188B (en) * | 2014-08-04 | 2016-03-16 | 廖为明 | Gynura procumbens (Lour.) Merr health preserving tea |
CN104173451A (en) * | 2014-09-12 | 2014-12-03 | 赵全成 | Application of natural pharmaceutical composition in blood glucose-reducing drugs and health food |
CN104173451B (en) * | 2014-09-12 | 2016-08-17 | 长春工业大学 | The application in blood sugar lowering medicine and health food of a kind of natural drug composition |
CN104367637A (en) * | 2014-11-06 | 2015-02-25 | 华洪萍 | Traditional Chinese medicine used for treating type 2 diabetes |
CN105920095A (en) * | 2016-06-12 | 2016-09-07 | 神威药业集团有限公司 | Application of traditional Chinese medicine composition for preparing medicines for treating diabetic complications |
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Publication number | Publication date |
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CN100352484C (en) | 2007-12-05 |
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