CN103656122B - Chinese medicine for the treatment of fever caused by exogenous pathogenic factors and preparation method thereof - Google Patents
Chinese medicine for the treatment of fever caused by exogenous pathogenic factors and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine and preparation method for the treatment of fever caused by exogenous pathogenic factors, it is prepared from by the raw material comprising following weight portion: Radix Isatidis, Herba Menthae, Radix Bupleuri, Rhizoma Pinelliae Preparatum, Radix Glycyrrhizae, Radix Scutellariae, Radix Platycodonis, Herba Taraxaci, Rhizoma Et Radix Notopterygii, Herba Artemisiae Annuae, Gypsum Fibrosum, Radix Clematidis, the Rhizoma Anemarrhenae, Flos Lonicerae.This Chinese medicine is upper respiratory tract infection or influenza to Western medicine diagnose, or the heating that bird flu or the viral disease such as hand-foot-mouth disease or mumps cause, Chinese medical discrimination is that the sun, the less patient of sun, Yangming Channel calentura are evident in efficacy, and through clinical observation, medication effective percentage reaches 96.0%.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine for the treatment of fever caused by exogenous pathogenic factors and preparation method thereof.
Background technology
Fever caused by exogenous pathogenic factors, refers to and invades human body, to generate heat for a class disease of cardinal symptom by exopathogen.This kind of disease is mainly acute infectious disease in modern medicine, and comprises generating heat for cardinal symptom, the disease caused by antibacterial or virus etc.Though this disease has self limiting, but clinical commonly encountered diseases and frequently-occurring disease, affect the study and work of patient greatly.
Chinese medicine is thought, fever caused by exogenous pathogenic factors is healthy energy and the fierce process disaccorded of warm pathogenic factor of human body, and take eliminating evil, righting treatment by dialectical, final human righteousness defeats pathogenic factor gradually and calentura is cured.In this process, because heresy can just hindered, internal organs in various degree, injuries of tissues and organs certainly will produced, and meridians, the disorder of qi-blood-body fluid and loss.The dialectical method being familiar with fever caused by exogenous pathogenic factors ancient times has three burnt, four layers, five sections, the saying of the six channels usually.Zhang Zhongjing treatise on Febrile Diseases take negative and positive as superclass, faints cloudy the six channels as dialectical guiding principle with bright, few positive, lunar, the Shao Yintun of the sun, sun, analyzes from aspects such as the advance and retreat emergencies of excess and weakness of pathogen and vital QI, diseased region and patient's condition, distinguishes fever caused by exogenous pathogenic factors.As treatise on Febrile Diseases have " after typhoid fever is recovered, more generate heat, Herba Sidae Rhombifoliae soup master it; Floating pulse person, with cure by diaphoresis it; Deep and forceful pulse person, below separates it " different method for the treatment of, namely to control it according to the state of an illness is dialectical; If after being ill, not to the greatest extent, Tianjin wound is not multiple, stomach-QI being unable to descend normally for waste heat, empty win weak breath, thirsty, red and uncoated tongue, not hungry nausea, controls and promotes the production of body fluid with treatise on Febrile Diseases Zhuye Shigao Tang, Lophatherum and Gypsum Dectoction (Folium Bambusae, Gypsum Fibrosum, the Rhizoma Pinelliae, Radix Ophiopogonis, Radix Ginseng, Radix Glycyrrhizae, Semen oryzae sativae) QI invigorating stomach function regulating, let out waste heat clearly.To the modern method also having some typical treatment by Chinese herbs fevers caused by exogenous pathogenic factors, as:
1, Lin County, Shanxi Province the People's Hospital Liu builds filial piety and has carried out the clinical application research of YINQIAO Baihu Tang in fever caused by exogenous pathogenic factors.Therapeutic Principle: the pungent table that cools completely, heat-clearing and toxic substances removing.Prescription: Flos Lonicerae 15g, Fructus Forsythiae 15g, Gypsum Fibrosum (being decocted first) 100g, Folium Bambusae 10g, Mentha haplocalyx Briq. 10g, Rhizoma Phragmitis 12g, Niu Fenzi 12g, Radix Bupleuri 12g, Radix Puerariae 12g, Radix Platycodonis 12g, Semen Sojae Preparatum 10g, Radix Glycyrrhizae 10g.(application of YINQIAO Baihu Tang in fever caused by exogenous pathogenic factors, China National folk medicine magazine, the 21st volume the 19th phase 34-34 in 2012)
2, Beijing University of Chinese Medicine's attached Huguo Temple hospital of traditional Chinese hospital Zhang Xiaoyu describes a routine warm class fever caused by exogenous pathogenic factors treatment case.Prescription: Folium Bambusae, method half is multiple, Radix Platycodonis, each 10g of stir-fry Fructus Gardeniae, Gypsum Fibrosum 30g, Flos Lonicerae, Radix Adenophorae (Radix Glehniae), Rhizoma Phragmitis, each 15g of Rhizoma Imperatae, Radix Ophiopogonis, Radix Scrophulariae, Semen Sojae Preparatum, each 12g of Radix Trichosanthis, Radix Glycyrrhizae 6g.(Zhang Xiangsheng treats fever caused by exogenous pathogenic factors experience and lifts corner, the Shaanxi traditional Chinese medical science, the 32nd volume the 6th phase 720-721 page in 2011)
3, Chinese patent CN03146749.0, fever caused by exogenous pathogenic factors is treated with heat clearing away and removing dampness two method conjunctive use, main body formula includes Herba Artemisiae Annuae, Caulis Bambusae In Taenia, the Rhizoma Pinelliae, Poria, Radix Scutellariae, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, BIYUSAN eight kinds of Chinese medicine ingredients altogether, can comprise at most Flos Lonicerae, Radix Paeoniae Rubra, Herba Houttuyniae, Bombyx Batryticatus, Rhizoma Atractylodis, Gypsum Fibrosum six kinds of Chinese crude drugs altogether in auxiliary formula.
4, Chinese patent CN200810137807.4 discloses a kind of Chinese medicine for the treatment of fever caused by exogenous pathogenic factors.It is characterized in that main component is by Concretio Silicea Bambusae 50 grams, Arisaema Cum Bile 25 grams, Bombyx Batryticatus 25, gram Herba Plantaginis 10 grams, Radix Et Rhizoma Rhei（streamed） 30 grams, Rhizoma Wenyujin Concisum 20 grams, the Rhizoma Pinelliae 10 grams, Periostracum Cicadae 25 grams, 2.5 grams, Borneolum Syntheticum, Rhizoma Alismatis 10 grams, 1.5 grams, Moschus, 25 grams, Cinnabaris, is ground into superfine mixing altogether by medicine-feeding, reserving a little Cinnabaris face is clothing.Each 50 grams of another Flos Lonicerae, Fructus Forsythiae, each 30 grams of RADIX PLATYCODI, Fructus Arctii, Herba Menthae, respectively, each 20 grams of mustard fringe, Folium Bambusae grinds for thick powder compositions such as (i.e. Lonicerae and Forsythiae Powder) for Semen Sojae Preparatum, Radix Glycyrrhizae each 25.Compound method: decoct Lonicerae and Forsythiae Powder with fresh reed root soup and concentrate established law, is in harmonious proportion above-mentioned powder, and refined honey is the pill that Semen phaseoli radiati is large, and with Cinnabaris face for clothing, every ball weighs 2 grams.
5, Chinese patent CN201010511320.5 discloses a kind of preparation method of Chinese traditional patent formulation anti-inflammatory antipyretic drop pill, and its prescription is: Folium Isatidis 400 parts, Herba Taraxaci 400 parts, Herba Violae 150 parts, 50 parts, Radix Glycyrrhizae.
Visible, Chinese medicine and pharmacy have accumulated rich experience in the viral fever caused by exogenous pathogenic factors for the treatment of, wherein have many dialectical administrated methods to be used so far always, and obtain great development, but administrated method is not quite similar.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine for the treatment of fever caused by exogenous pathogenic factors;
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine of fever caused by exogenous pathogenic factors.
The object of the invention is by following technical scheme realize:
The Chinese medicine for the treatment of fever caused by exogenous pathogenic factors of the present invention is prepared from by the raw material comprising following weight portion:
Radix Isatidis 20 ~ 40 portions of Herba Menthaes 5 ~ 15 parts of Radix Bupleuri 10 ~ 20 parts of Rhizoma Pinelliae Preparatum 10 ~ 20 parts
Radix Glycyrrhizae 2 ~ 10 parts of Radix Scutellariaes 10 ~ 20 parts of Radix Platycodoniss 5 ~ 15 parts of Herba Taraxacis 20 ~ 40 parts
Rhizoma Et Radix Notopterygii 5 ~ 15 portions of Herba Artemisiae Annuaes 10 ~ 20 parts of Gypsum Fibrosum 5 ~ 15 parts of Radix Clematidis 10 ~ 20 parts
The Rhizoma Anemarrhenae 5 ~ 20 portions of Flos Loniceraes 5 ~ 25 parts.
The Chinese medicine for the treatment of fever caused by exogenous pathogenic factors of the present invention, its preferred version is prepared from by the raw material comprising following weight portion:
Radix Isatidis 25 ~ 35 portions of Herba Menthaes 7 ~ 13 parts of Radix Bupleuri 13 ~ 18 parts of Rhizoma Pinelliae Preparatum 13 ~ 18 parts
Radix Glycyrrhizae 4 ~ 8 parts of Radix Scutellariaes 12 ~ 17 parts of Radix Platycodoniss 7 ~ 13 parts of Herba Taraxacis 25 ~ 35 parts
Rhizoma Et Radix Notopterygii 7 ~ 13 portions of Herba Artemisiae Annuaes 12 ~ 17 parts of Gypsum Fibrosum 7 ~ 13 parts of Radix Clematidis 13 ~ 18 parts
The Rhizoma Anemarrhenae 12 ~ 17 portions of Flos Loniceraes 10 ~ 20 parts.
The Chinese medicine for the treatment of fever caused by exogenous pathogenic factors of the present invention, its further preferred version is prepared from by the raw material comprising following weight portion:
6 parts, Radix Isatidis 30 portions of Herba Menthaes 10 parts of Radix Bupleuri 15 parts of Rhizoma Pinelliae Preparatum 15 portions of Radix Glycyrrhizaes
Radix Scutellariae 15 parts of Radix Platycodoniss 10 parts of Herba Taraxacis 30 portions of Rhizoma Et Radix Notopterygiis 10 portions of Herba Artemisiae Annuaes 15 parts
Gypsum Fibrosum 10 parts of Radix Clematidis 15 parts of Rhizoma Anemarrhenaes 10 portions of Flos Loniceraes 15 parts.
The Chinese crude drug details adopted in the present invention is as follows:
Radix Isatidis: Isatis indigotica Fort, crucifer, the dry root of Isatis indigotica Fort., has heat-clearing and toxic substances removing, antibacterial, antiviral effect.
Herba Menthae: the dry aerial parts of labiate Herba Menthae Mentha haplocalyx Briq., pungent cool property sweating antipyretic medicine, control influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache, external can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.
Radix Bupleuri: RootofChneseThorowax, samphire, beginning to be loaded in Shennong's Herbal, is clearind deficient heat Chinese medicine, can be used for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus come off, menoxenia.
Rhizoma Pinelliae Preparatum: Rhizoma Pinelliae, is the tuber of the aroid Rhizoma Pinelliae, cures mainly drying dampness to eliminate phlegm, and for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache.
Radix Glycyrrhizae: the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.
Radix Scutellariae: Scutellaria baicalensis Georgi, labiate Radix Scutellariae, is used as medicine with root.Have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions, cures mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia.
Radix Platycodonis: Platycodon grandiforus, campanulaceae Platycodon grandiflouorum plant is the dried roots of Campanulaceae Radix Platycodonis, bitter in the mouth, pungent, slightly warm in nature.Enter lung meridian.Energy expelling phlegm for arresting cough, and have lung qi dispersing, evacuation of pus effect.
Herba Taraxaci: feverfew Herba Taraxaci Toraxacum mongolicum Hand. Mazz., alkali ground Herba Taraxaci Toraxacum borealisinense Kitam. or belong to the dry herb of several plants together, the flat sweet and slightly bitter taste of property, has effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Rhizoma Et Radix Notopterygii: the dry rhizome of samphire Rhizoma Et Radix Notopterygii Notopterygium incisum Ting ex H. T. Chang or Radix et Rhizoma Notopterygii Notopterygium forbesii Boiss. and root.Acrid in the mouth, hardship, warm in nature, loose exterior cold, wind-damp dispelling, sharp joint, pain relieving.Main affection of exogenous wind-cold; Have a headache lossless; Mimeograph cold-damp numbness; Edema due to wind pathogen edema; Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.Induce sweat cold expelling, expelling wind and dampness, pain relieving.
Herba Artemisiae Annuae: feverfew Herba Artemisiae annuae Artemisia annua L. dry aerial parts.Bitter in the mouth, pungent, cold in nature, return liver, gallbladder meridian, three burnt, kidney channels.Clear deficiency-heat thoroughly, removing heat from blood, except steaming, removes and steams, preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.
Gypsum Fibrosum: main chemical compositions is CaSO
4nH
2o, heat clearing and fire purging medicine, acrid in the mouth, sweet, be slightly cold, attach to the lung and stomach meridians.Clearly
Diarrhea of heat type fire, relieving restlessness is quenched the thirst, convergence granulation promoting.Normal and Rhizoma Anemarrhenae mutual reinforcement between compatibility, for the syndrome of epidemic febrile disease edema caused by disorder of QI excess-heat.
Radix Clematidis: Clematis chinensis, cohosh, bitter in the mouth is pungent, warm in nature, its root and stem be used as medicine there is rheumatism, effect that the meridian dredging, the bone that disappears are choked.
The Rhizoma Anemarrhenae: the dry rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bge., gunpowder under genus heat clearing away, cures mainly: epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness etc.
Flos Lonicerae: caprifoliaceae plant, the flower that the dry flower of Radix Ophiopogonis Lonicera japonica Thunb. Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae Lonicera confusa DC. hair style Radix Ophiopogonis Lonicera dasystyla Rehd. or band are just opened, there is heat-clearing and toxic substances removing, effect of wind-heat dissipating.
Another aspect of the present invention there is provided the preparation method of active ingredient of Chinese herbs of the present invention, and the method is the ethanol extraction adopting water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: get whole 14 taste medical materials, extracting in water 2-3 time, add the water being equivalent to medical material gross weight 6 ~ 10 times at every turn, extracts 1 ~ 3 hour; Merge extractive liquid, when being concentrated into 60-80 DEG C, relative density is the extractum of 1.10 ~ 1.20, adding ethanol to alcohol content concentration of volume percent is 50% ~ 60%, stir, leave standstill 12 ~ 24 hours, filter, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10 ~ 1.20, obtains described active component.
Scheme two: get whole 14 taste medical materials, add 40-80% alcohol reflux 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
The Chinese medicine for the treatment of fever caused by exogenous pathogenic factors of the present invention, with pharmaceutically acceptable carrier combination, can make various common dosage forms.
Such as, various common dosage forms can be prepared as by one of following method:
Method 1: Chinese medicine capsules of the present invention
Get scheme 1 or scheme 2 gained active component, add capsule and commonly use adjuvant, production method is prepared into the capsule of Chinese medicine of the present invention routinely.
Method 2: Chinese medicinal tablet of the present invention
Get scheme 1 or scheme 2 gained active component, add tablet and commonly use adjuvant, production method is prepared into the tablet of Chinese medicine of the present invention routinely.
Method 3: Chinese medicine granules of the present invention
Get scheme 1 or scheme 2 gained active component, add granule and commonly use adjuvant, production method is prepared into the granule of Chinese medicine of the present invention routinely.
Method 4: herb mixture of the present invention
Get scheme 1 or scheme 2 gained active component, add mixture and commonly use adjuvant, production method is prepared into the mixture of Chinese medicine of the present invention routinely.
Method 5: Chinese medicine oral liquid of the present invention
Get scheme 1 or scheme 2 gained active component, add oral liquid and commonly use adjuvant, production method is prepared into the oral liquid of Chinese medicine of the present invention routinely.
Fever caused by exogenous pathogenic factors, because exopathogen is from mouth and nose, fur going from the exterior into the interior damage internal organs, pathogenic factor in the exterior enters between the exterior and the interior, must not declare loose, and qi-blood-body fluid burns into the stasis of blood, expectorant, thus with the poison that expels the heat-evil clearly, Replenishing QI and nourishing YIN is dialectical treats, can complication be prevented and treated, prevent disease from arranging.The Chinese medicine for the treatment of fever caused by exogenous pathogenic factors of the present invention, Flos Lonicerae, Herba Taraxaci have effect of heat-clearing and toxic substances removing sore-throat relieving, can remove rapidly the epidemic disease due to heat pathogen caused into external heresy, with Radix Isatidis, Radix Platycodonis compatibility anti-bacteria and anti-virus, and can dispel gas Tianjin burn formed the expectorant stasis of blood; Coordinate relieving the exterior syndrome with drugs of pungent in flavor and warm in nature dehumidifying medicine Rhizoma Et Radix Notopterygii again, exterior cold of can faling apart, alleviates head body, person's back, joint, the myalgia caused by calentura; Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae Preparatum can move back the heat of shaoyang channel; Gypsum Fibrosum, the Rhizoma Anemarrhenae can remove the large heat of Yangming Channel.All medicines share above, can treating SHAO YANG disease by mediation, declare smooth mechanism of qi, three YANG meridians heat of ruling together, remove the various symptoms caused into external heresy, take good care of taste, have good curative effect to the anxious card for the treatment of fever caused by exogenous pathogenic factors.
A kind of Chinese medicine for the treatment of fever caused by exogenous pathogenic factors provided by the invention has the following advantages:
1, the present invention remove cause because of affection due to external wind and heat heating, aversion to cold, thirsty, pharyngalgia, headache, general pain, the symptoms such as cough have significant curative effect, rapidly antipyretic, not easily repeatedly.
2, clinical test results shows, Chinese medicine of the present invention compares with matched group ribavirin tablet, quick of phenol ammonia coffee, and be obviously better than matched group, effective percentage reaches 96.0%; And in the clinical process treated, have no toxic and side effects, safe and reliable.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1
Radix Isatidis 300g Herba Menthae 100g Radix Bupleuri 150g Rhizoma Pinelliae Preparatum 150g Radix Glycyrrhizae 60g
Radix Scutellariae 150g Radix Platycodonis 100g Herba Taraxaci 300g Rhizoma Et Radix Notopterygii 100g Herba Artemisiae Annuae 150g
Gypsum Fibrosum 100g Radix Clematidis 150g Rhizoma Anemarrhenae 100g Flos Lonicerae 150g
Get whole 14 taste medical materials, extracting in water 2 times, add the water being equivalent to medical material gross weight 10 times, 8 times amount at every turn respectively, each extraction time is respectively 3 hours, 2 hours; Merge extractive liquid, when being concentrated into 60 DEG C, relative density is the extractum of 1.20, and adding ethanol to alcohol content is 50%, stirs, and leaves standstill 12 hours, filters, and when filtrate is concentrated into 60 DEG C, relative density is the extractum of 1.20, obtains described active component.
Embodiment 2
Radix Isatidis 200g Herba Menthae 50g Radix Bupleuri 100g Rhizoma Pinelliae Preparatum 100g Radix Glycyrrhizae 20g
Radix Scutellariae 100g Radix Platycodonis 50g Herba Taraxaci 200g Rhizoma Et Radix Notopterygii 50g Herba Artemisiae Annuae 100g
Gypsum Fibrosum 50g Radix Clematidis 100g Rhizoma Anemarrhenae 50g Flos Lonicerae 50g
Get whole 14 taste medical materials, extracting in water 3 times, add respectively at every turn and be equivalent to medical material gross weight 10 times, 8 times, the water of 6 times amount, each extraction time is respectively 3 hours, 2 hours, 1 hour; Merge extractive liquid, when being concentrated into 80 DEG C, relative density is the extractum of 1.10, and adding ethanol to alcohol content is 60%, stirs, and leaves standstill 24 hours, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, obtains described active component.
Above-mentioned active component is mixed with suitable amount of sucrose, makes granule, dry, obtain granule of the present invention.
Embodiment 3
Radix Isatidis 200g Herba Menthae 150g Radix Bupleuri 200g Rhizoma Pinelliae Preparatum 200g Radix Glycyrrhizae 100g
Radix Scutellariae 200g Radix Platycodonis 150g Herba Taraxaci 200g Rhizoma Et Radix Notopterygii 150g Herba Artemisiae Annuae 200g
Gypsum Fibrosum 150g Radix Clematidis 200g Rhizoma Anemarrhenae 200g Flos Lonicerae 200g
Get whole 14 taste medical materials, add 40% alcohol reflux 2 times, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 2 hours, merge extractive liquid, filters, when filtrate is concentrated into 60 DEG C, relative density is the extractum of 1.25, obtains active component.
Mixed with appropriate amount of starch and dextrin by above-mentioned active component, granulate, dry, tabletting, obtains tablet of the present invention.
Embodiment 4
Radix Isatidis 250g Herba Menthae 130g Radix Bupleuri 180g Rhizoma Pinelliae Preparatum 180g Radix Glycyrrhizae 80g
Radix Scutellariae 170g Radix Platycodonis 130g Herba Taraxaci 350g Rhizoma Et Radix Notopterygii 130g Herba Artemisiae Annuae 170g
Gypsum Fibrosum 130g Radix Clematidis 180g Rhizoma Anemarrhenae 170g Flos Lonicerae 250g
Get whole 14 taste medical materials, add 80% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, extraction time is respectively 4 hours, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, obtains active component.
Above-mentioned active component is mixed with suitable amount of sucrose, water, obtains oral liquid of the present invention.
Embodiment 5
Radix Isatidis 250g Herba Menthae 70g Radix Bupleuri 130g Rhizoma Pinelliae Preparatum 130g Radix Glycyrrhizae 40g
Radix Scutellariae 120g Radix Platycodonis 70g Herba Taraxaci 250g Rhizoma Et Radix Notopterygii 70g Herba Artemisiae Annuae 120g
Gypsum Fibrosum 70g Radix Clematidis 130g Rhizoma Anemarrhenae 120g Flos Lonicerae 100g
Get whole 14 taste medical materials, extracting in water 3 times, add respectively at every turn and be equivalent to medical material gross weight 8 times, 8 times, the water of 6 times amount, each extraction time is respectively 3 hours, 2 hours, 2 hours; Merge extractive liquid, when being concentrated into 70 DEG C, relative density is the extractum of 1.15, and adding ethanol to alcohol content is 60%, stirs, and leaves standstill 18 hours, filters, and when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.15, obtains described active component.
By active component vacuum drying under 65 DEG C ~ 70 DEG C conditions, pulverized 100 mesh sieves, and added appropriate amount of starch, silicon dioxide, magnesium stearate, make granule, incapsulate, obtained capsule of the present invention.
Embodiment 6
Radix Isatidis 30g Herba Menthae 10g Radix Bupleuri 15g Rhizoma Pinelliae Preparatum 15g Radix Glycyrrhizae 6g
Radix Scutellariae 15g Radix Platycodonis 10g Herba Taraxaci 30g Rhizoma Et Radix Notopterygii 10g Herba Artemisiae Annuae 15g
Gypsum Fibrosum 10g Radix Clematidis 15g Rhizoma Anemarrhenae 10g Flos Lonicerae 15g
Get whole 14 taste medical materials, cleaning, drying and sterilizing, pulverize, cross 80 orders ~ l20 mesh sieve, obtain powder of the present invention.
clinical trial
The curative effect of the present invention being treated to fever caused by exogenous pathogenic factors carries out clinical observation, by contrast take medicine Patients Before And After antipyretic, analgesia, antiinflammatory situation check fever caused by exogenous pathogenic factors whether take a turn for the better analyze therapeutic effect of the present invention.
1 ureteral calculus diagnosis basis: " fever caused by exogenous pathogens curative effect determinate standard " (fever caused by exogenous pathogenic factors)
2 case selections
3 ~ 60 years old age, tcm syndrome belong to affection of exogenous wind-cold, in accumulate hot and suffocating card person; Get rid of gestation and women breast-feeding their children, psychotic, merge intentionally, Liver and kidney function and the serious primary disease person of hemopoietic system, used other treatment medicine person, allergic constitution or multi-medicament allergy sufferers.
3 medicines
Experimental group: embodiment 2 granule;
Matched group: ribavirin tablet, Shanghai Hua Surname Pharmaceutical Co., Ltd.; Quick of phenol ammonia coffee, Shanghai Xinyi Pharmaceutical Factory.
4 curative effect index
Cure: heat is cool skin to the greatest extent, and nothing repeatedly, cardinal symptom disappears, and abnormal physico-chemical examination index recovers normal;
Effective: heating has been moved back and without repeatedly, cardinal symptom major part disappears, and abnormal physico-chemical examination index is close to normal;
Effective: heating is moved back, but also have repeatedly, cardinal symptom partial disappearance, abnormal physico-chemical examination index makes moderate progress;
Invalid: generate heat persistent, symptom is not improved, abnormal physico-chemical examination index is not improved.
5 clinical grouping and Therapeutic Method
Enter to organize the routine patient of case 350, man 178 example, female 172 example; All patients all meet relevant fever caused by exogenous pathogenic factors diagnostic criteria, Chinese medical discrimination is the sun, few sun, (heating is heavy for Yangming Channel calentura, light or the alternate attack of chill and fever of aversion to cold or high fever thirsty, there is antiperspirant or lossless, pharyngalgia and/or headache, general pain, cough, red tongue, yellow fur, floating and rapid pulse or loud), the patient of the course of disease in 3 days.Case is divided into two groups at random.
Therapeutic Method:
Experimental group: the embodiment of the present invention 2, each serving with the medicine being equivalent to crude drug amount 100g, three times on the one;
Matched group: ribavirin tablet, 3-4 times/day; Quick of phenol ammonia coffee, 3 times/day.
6 results
Therapeutic effect: carry out clinical treatment to 350 patients, observing effect is as follows:
Table 1 clinical efficacy table
| Cure | Effective | Effectively | Invalid | Total effective rate (%) | |
| Experimental group | 148 | 12 | 8 | 7 | 96.0 * |
| Matched group | 28 | 22 | 94 | 31 | 82.3 |
Note: experimental group compares with matched group, * P < 0.05
Table 1 result shows: experimental group and reference group all have more significant effective percentage treating fever caused by exogenous pathogenic factors, but the therapeutic effect of medicine of the present invention is compared with quick of phenol ammonia coffee with Western medicine ribavirin tablet, there is significant difference, especially in antipyretic completeness, after the present invention is antipyretic not easily repeatedly, Western medicine only separates exterior heat, easily repeatedly generates heat, from result, Drug therapy fever caused by exogenous pathogenic factors effect of the present invention is better than control drug.
model case:
The concrete Clinical practice case of Chinese medicine of the present invention:
1, Chen, man, 21 years old, main suit: generate heat 39.5 DEG C, companion's pharyngalgia, cough 2 days.After diagnosing, tcm syndrome belong to affection of exogenous wind-cold, in accumulate hot and suffocating card, cause heating and tonsil inflammation.Give the embodiment of the present invention 3 tablet, one day 3 times, after taking one day, heat retreats to 38.5 DEG C, and pharyngalgia slightly alleviates, and returns to normal body temperature after taking 5 days, and do not occur repeatedly generating heat, pharyngalgia disappears, and is judged as recovery from illness.
2, Wu, man, 3 years old, main suit: repeatedly generate heat two days, taking Western medicine cannot be thoroughly antipyretic, was reluctant to take food, cough.After diagnosing, tcm syndrome belongs to affection of exogenous wind-cold, causes upper respiratory tract infection, and tonsil is red and swollen.Give the embodiment of the present invention 4 oral liquid, one day 3 times, after taking one day, perspire, take temperature and be down to normal value, minimizing of crying and screaming, advise many hello boiled water, then after taking 2 days, cough obviously reduces, and repeatedly raising does not appear in body temperature, and tonsil redness disappears, and is judged as recovery from illness.
3, thank certain, female, 42 years old, main suit: the day before yesterday generates heat suddenly, companion's throat severe pain, dysdipsia, buy ibuprofen by oneself in pharmacy and take one day, symptom alleviates, but always midnight again suddenly fever accompany pharyngalgia to fall asleep.After diagnosing, be exogenous high fever emergency case.Give the embodiment of the present invention 2 granule, one day 3 times, take two doses, a large amount of diaphoresis, body temperature is down to normal value, then after taking 5 days, pharyngalgia disappears, and body temperature raises no longer repeatedly, is judged as recovery from illness.
4, Wang, female, 15 years old, main suit: headache, general pain, pharyngalgia 1 day.Through looking into, body temperature is 39.1 DEG C, rapid pulse, aversion to cold, and tcm syndrome belongs to fever caused by exogenous pathogenic factors.Give the embodiment of the present invention 5 capsule, one day 3 times, after taking one day, temperature recovery is normal, and whole body is soft tiredly slightly to be alleviated, and after taking 3 days, do not occur repeatedly generating heat, the transference cures such as headache, general pain, pharyngalgia, are judged as fully recovering.
Claims (7)
1. treat a Chinese medicine for fever caused by exogenous pathogenic factors, it is characterized in that it is prepared from by the raw material of following weight portion:
2. the Chinese medicine for the treatment of fever caused by exogenous pathogenic factors as claimed in claim 1, is characterized in that it is prepared from by the raw material of following weight portion:
3. the Chinese medicine for the treatment of fever caused by exogenous pathogenic factors as claimed in claim 2, is characterized in that it is prepared from by the raw material of following weight portion:
4. the Chinese medicine of the treatment fever caused by exogenous pathogenic factors as described in one of claim 1-3, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. the Chinese medicine for the treatment of fever caused by exogenous pathogenic factors as claimed in claim 1, is characterized in that its active component is prepared from by the following method:
Get whole 14 taste medical materials, extracting in water 2-3 time, add the water being equivalent to medical material gross weight 6 ~ 10 times at every turn, extract 1 ~ 3 hour; Merge extractive liquid, when being concentrated into 60-80 DEG C, relative density is the extractum of 1.10 ~ 1.20, adding ethanol to alcohol content concentration of volume percent is 50% ~ 60%, stir, leave standstill 12 ~ 24 hours, filter, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10 ~ 1.20, obtains described active component.
6. the Chinese medicine for the treatment of fever caused by exogenous pathogenic factors as claimed in claim 1, is characterized in that its active component is prepared from by the following method:
Get whole 14 taste medical materials, add 40-80% alcohol reflux 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
7. treat a Chinese medicine preparation for fever caused by exogenous pathogenic factors, Chinese medicine and the pharmaceutically acceptable carrier combination of the treatment fever caused by exogenous pathogenic factors any one of claims 1 to 3 are prepared from.
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| CN106581294A (en) * | 2016-11-30 | 2017-04-26 | 四川旭华制药有限公司 | Antipyretic pharmaceutical composition |
| CN108210582A (en) * | 2018-03-30 | 2018-06-29 | 湖北大顶山制药有限公司 | A kind of Chinese medicinal granule for being used to treat and prevent viral influenza |
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| 甘璐等.清感退热汤治疗小儿外感发热临床体会.《陕西中医》.2012,第33卷(第12期), * |
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