CN103961614A - Traditional Chinese medicine composition for treating respiratory system diseases as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating respiratory system diseases as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating respiratory system diseases, particularly relates to a traditional Chinese medicine composition for treating cough and meanwhile relates to a preparation method of the composition and a pharmaceutical application of the composition. The traditional Chinese medicine composition is prepared from radix bupleuri, scutellaria baicalensis, pinellia ternata, inula flower, herba schizonepetae, tartarian aster, radix stemonae, cynanchum glaucescens, platycodon grandiflorum, dried tangerine peel, liquorice, loquat leaf and perilla leaf, can be used for effectively treating cough and/or related diseases and has a relative good treatment effect on various traditional Chinese medicine and western medicine type cough by and large.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be particularly used for the treatment of the Chinese medicine composition of respiratory system disease, especially treat the Chinese medicine composition of cough, also relate to preparation method and the pharmaceutical applications of this Chinese medicine composition simultaneously.
Background technology
Respiratory system disease is a kind of commonly encountered diseases, frequently-occurring disease, and along with development of modern industry, air pollution is day by day serious.Extraneous harmful substance, as various harmful gass, dust, sensitization microorganism and sensitinogen directly suck pulmonary, is all increasing respiratory system sickness rate and case fatality rate.Within 1998, rural areas in our country sampling survey respiratory diseases mortality occupy the first, accounts for 25% of general mortality rate.What Shanghai Residents hospital admission accounted for first place is also respiratory system disease.According to incompletely statistics, this disease adult's sickness rate is 5%, and old man and child's sickness rate is higher, therefore, exploitation treatment respiratory system disease new drug, its market capacity is very large, and its economic benefit and social benefit are obvious.
In recent years to respiratory system disease common cough, expectorant, the etiology and pathology breathed heavily is learned and mutual relation has had the understanding of a step, wherein can be considered as respiratory system disease the most common in cough, is topmost disease, pathological change and/or symptom.For cough, cough is also clinical commonly encountered diseases and frequently-occurring disease separately.Polyphyly six climate exopathogens diseases caused by exogenous pathogenic factor, or visceral dysfunction, violate and lungs, causes impaired depurative descending of lung QI, abnormal rising of lung-QI and for coughing, for coughing.
As far back as interior, through < < Plain Questions, cough an opinion > > piece of writing, point out that its cause of disease divides inside and outside two aspects.Exopathogenic factor is mainly affection of exogenous wind-cold, by fur, is entered, and inside closing in lung is disease.It is so-called that " fur is first subject to pathogen for fur person, the closing also of lung, and pathogen is to close also from it." endogenous cause of ill enters stomach for cold, heat, violate in lung and cause and cough.Jin Dynasty Liu Wansu, Zhang Zihe more clearly connect cough with six gas, propose " wind, cold, summer-heat, wet, dry, fire all make us coughing " and " minute six gas of coughing are said without arresting in cold ", further illustrating to cough and " six climate exopathogens " all have relation.< < danxi's experiential therapy cough > > is divided into five kinds of wind and cold, phlegm retention, fire stagnation, chronic cough, pulmonary distension.
Ming Dynasty more has new supplementing to the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of cough, king's synthetic fibre in < < collection of experiences of famous physicians in the Ming Dynasty opinion cough card is controlled > >, point out " method for the treatment of is must minute new prolonged deficiency real; new sick wind and cold loose it; intimately clear it, damp and hotly rush down it, that prolonged illness belongs to is empty, belong to strongly fragrant; the deficiency of vital energy is QI invigorating; blood deficiency is enriched blood, the Yu Ze dissipating depression of QI of holding concurrently, the method for controlling void of grow it, moisten it, holding back also." emphasize to control cough must point six climate exopathogens seven emotions and the five internal organs win mutually, spleen deficiency of the lung reality.Li Mu prolongs < < Elementary Medicine > > and first proposes diseases caused by exogenous pathogenic factor, internal injury classification, for dialectical main points are provided later age.< < Jing Yue's complete work cough > > discusses quite detailed to diseases caused by exogenous pathogenic factor, endogenous cough's the cause of disease, pathogenesis, syndrome, treatment, exogenous cough is proposed by lung and he is dirty, therefore take lung as this, he is dirty is target opinion, endogenous cough is and lung dirty by him, therefore take, he is dirty is this, and lung is mark.Also diseases caused by exogenous pathogenic factor, endogenous cough dialectical proposed to some main points.
The historical classical medicine of respiratory system disease and in recent years to develop new drug quite a few, but because various reason curative effects are not ideal enough.Therefore develop efficient, quick-acting cough suppressing medicines, seem very important.
Zhisou San comes from < < Medicine Comprehended > > volume three.Side is by respectively two jin of Radix Platycodonis (stir-fry), Herba Schizonepetae, Radix Asteris (steaming), the Radix Stemonae (steaming), Rhizoma Cynanchi Stauntoniis (steaming), 12 liang, Radix Glycyrrhizae (stir-fry), one jin of composition of Pericarpium Citri Reticulatae (washing is gone white).Be end altogether, every three money that take, under boiled water is adjusted, face sleeping clothes after food.Just feel wind and cold, under Rhizoma Zingiberis Recens soup is adjusted.Function antitussive reduces phlegm, diffusing lung, relieving exterior syndrome.Cure mainly exogenous cough, cough and itching throat, cough up phlegm not well, micro-have fever with aversion to wind, thin white fur of tongue, a floating and moderate pulse person.Our institute controls card and belongs to wind and cold criminal lung, and inhibited pulmonary QI, controls suitable relieving cough and resolving phlegm, diffusing lung, relieving exterior syndrome.Radix Asteris in side, Radix Stemonae bitter in the mouth and profit warm in nature, the therapeutic method to keep the adverse QI flowing downwards is reduced phlegm, and reason lung antitussive is all monarch drug; Radix Platycodonis is opened lung qi dispersing gas, the antitussive that eliminates the phlegm, and Rhizoma Cynanchi Stauntonii sending down the abnormal ascending QI expectorant and cough-relieving is ministerial drug, the monarch and his subjects are harmonious, and lifting use, therefore can regulate the imbalance of ascending or descending movement of vital Qi; Assistant with Pericarpium Citri Reticulatae activating QI to eliminate phlegm, cough by cough-relieving, Herba Schizonepetae dispelling wind to relieve the exterior syndrome and smooth lung qi; Make with Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, with the same use of Radix Platycodonis, again can clearing throat.Though medicine seven tastes, the temperature of having is not and dry, and profit is and oiliness, and cold expelling does not help heat, and the feature just of not hindering of inducing sweat, for controlling effective prescription of general exogenous cough.We belong to relieving cough and resolving phlegm, the agent of dispelling wind to relieve the exterior syndrome.Gentle peace, cold not hot, be mainly used in exogenous cough, be more so applicable to exogenous cough more of a specified duration, cough itching throat, micro-have a fever with aversion to wind.Though we's property is gentle, always belong to pungent-warm prescription, therefore deficiency of YIN chronic cough person should not use.
Unexpectedly, inventor finds through research extensively and profoundly, although Zhisou San has produced remarkable curative effect in the age of being created, but due to the change of environment and the variation of patient's body constitution, as air pollution, being widely used or absorbing of synthetic chemical substance, the factors such as pm2.5 and patient's dietary habit, the reasons such as living habit, Zhisou San can not produce good therapeutic effect at present more clinically, therefore, inventor is through research for many years, have been surprisingly found that, adjust the raw material of Chinese medicine weight proportion of Zhisou San and add and significantly change the rear new Chinese medicine composition forming of prescription composition, the curative effect with highly significant is improved, and be highly suitable under modern environment condition and be widely used for the respiratory system disease patient crowd that particularly coughs as basic prescription.
Although modern TCM be take Zhisou San and is conducted extensive research as basis, as " Zhisou San plus-minus treatment cough 31 routine clinical observations " (Gansu college of traditional Chinese medicine journal, Ma Weiping, the 20th the 2nd phase of volume, 33-34 page) point out that Zhisou San in vain, often accompanies stuffy nose with watery discharge, headache, aching and soreness in limb, fever with aversion to cold, the exterior syndrome such as lossless for cough, low voice speaking, out of breath, itching throat, the thin color of expectoration, thin white fur of tongue, floating pulse or floating tight.If point out that with card plus-minus companion's fever and aversion to wind, general malaise person add Folium Mori, Flos Chrysanthemi, with wind and heat dispersing, lung qi dispersing cough-relieving; Whole body pain is obvious, person with anhidrosis adds Herba Ephedrae, Ramulus Cinnamomi, with lung qi dispersing expelling cold and relieving exterior syndrome; The throat person of having an itch adds Radix Puerariae, Periostracum Cicadae, Fructus Arctii, with wind and heat dispersing sore-throat relieving; Red swelling and pain of throat person adds Fructus Arctii, Lasiosphaera Seu Calvatia, with relieving sore-throat by clearing away heat; Cough more very person adds Folium Eriobotryae, Semen Armeniacae Amarum, Bulbus Fritillariae Thunbergii, Cortex Mori, with removing heat-phlegm sending down the abnormal ascending QI; Hot severe one adds Radix Scutellariae, Gypsum Fibrosum, with clear eliminating the pathogens from the lung heat; Nasal obstruction sound severe one adds Fructus Xanthii, Flos Magnoliae, and to fall apart, wind is opened clearing the nasal passage; , expectoration thickness uncomfortable in chest if cough, be difficult to the person of bringing up and add Poria, the Rhizoma Pinelliae, with drying dampness to eliminate phlegm; Xerostomia is thirsty, Tianjin is hindered obvious person and added Radix Adenophorae (Radix Glehniae), Radix Ophiopogonis, with replenishing YIN and removing heat, promotes the production of body fluid; The companion person of panting adds Cortex Mori, Fructus Perillae, with the hot lowering the adverse-rising QI to resolve phlegm of clear eliminating the pathogens from the lung.Yet above-mentioned research is only pointed out to add and subtract part raw material of Chinese medicine according to indivedual conditions of patients differences with card, is not applicable to but form the basic prescription that extensive crowd uses, and, verifies through inventor meanwhile, successful of the present invention is better than above-mentioned prescription.
Chinese patent application CN101496881A discloses a kind of cough syrup and preparation method thereof, and its crude drug is Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Semen Coicis, Herba Schizonepetae, Radix Asteris, the Radix Stemonae, Pericarpium Citri Reticulatae, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Flos Lonicerae, Cortex Mori, Folium Eriobotryae, Mel.Above-mentioned prescription is that MAXINGSHIGAN TANG, Zhisou San increase Flos Lonicerae, Cortex Mori, Folium Eriobotryae, Mel again and forms, still, above-mentioned syrup primary treatment be respiratory tract infection, and do not have enough clear and definite curative effect data to prove its effect.
Chinese patent application CN1899550A discloses a kind of outer plaster for the treatment of infantile cough due to cold, expelling wind and cold, lung qi dispersing cough-relieving, activating QI to eliminate phlegm, invigorating spleen to remove dampness, intestinal stasis relieving in tune.Cure mainly: the cough that children's exogenous wind and cold or internal damage caused by infantile dyspepsia etc. cause, expectorant color is white, swallow overworked, stuffy nose with watery discharge, aversion to cold is lossless, head-body-pain is uncomfortable in chest indigestion and loss of appetite, sleepy weak, light red tongue, tongue is waited card in vain.Component and the weight portion thereof of its material medicine are: Folium Perillae 0.5-2, Radix Peucedani 2-5, Radix Platycodonis 1-3, Fructus Perillae 2-5, Herba Inulae 1-3, Radix Stemonae 0.5-1, Herba Schizonepetae 0.5-1, Pericarpium Citri Reticulatae 0.5-1.5, Folium eucalypti globueli (Eucalyptus globulus Labill.) 0.5-1.5, the Radix Angelicae Dahuricae 0,2-1, Poria 0.2-1, Rhizoma Atractylodis 0.1-0.5, Radix Scutellariae 0.01-0.1.But said medicine is external used medicine, and be only applicable to children's.
The present invention is through laboratory and clinical research widely, beat allly found the prescription in the application, and it can effectively treat upper respiratory system disease and/or relevant disease, and as cough etc., it has good therapeutical effect to various types of coughs substantially.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of respiratory system disease, further the present invention also aims to provide a kind of method and pharmaceutical applications thereof of preparing above-mentioned composition.
More specifically, the object of the present invention is to provide a kind of Chinese medicine composition for the treatment of cough.
More specifically, the object of the present invention is to provide a kind of Chinese medicine composition with the treatment cough of significant curative effect.
Further concrete, to the object of the present invention is to provide a kind of tool treatment to cough Chinese medicine composition, has significant synergism between its crude drug.
Chinese medicine composition of the present invention is made (weight proportion relation) by following crude drug:
Radix Bupleuri 8-12, Radix Scutellariae 8-12, Rhizoma Pinelliae 8-12, Flos Inulae 8-12, Herba Schizonepetae 8-12, Radix Asteris 13-18, Radix Stemonae 13-18, Rhizoma Cynanchi Stauntonii 13-18, Radix Platycodonis 13-18, Pericarpium Citri Reticulatae 8-12, Radix Glycyrrhizae 3-7, Folium Eriobotryae 13-18, Folium Perillae 8-12.
The optimum ratio of the invention described above composition material medicine is (weight proportion relation):
Radix Bupleuri 8-10, Radix Scutellariae 8-10, Rhizoma Pinelliae 8-10, Flos Inulae 8-10, Herba Schizonepetae 8-10, Radix Asteris 15-18, Radix Stemonae 15-18, Rhizoma Cynanchi Stauntonii 15-18, Radix Platycodonis 15-18, Pericarpium Citri Reticulatae 8-10, Radix Glycyrrhizae 3-5, Folium Eriobotryae 15-18, Folium Perillae 8-10.
Particularly, the optimum ratio of the invention described above composition material medicine is:
Radix Bupleuri 8, Radix Scutellariae 8, the Rhizoma Pinelliae 8, Flos Inulae 8, Herba Schizonepetae 8, Radix Asteris 15, the Radix Stemonae 15, Rhizoma Cynanchi Stauntonii 15, Radix Platycodonis 15, Pericarpium Citri Reticulatae 8, Radix Glycyrrhizae 3, Folium Eriobotryae 15, Folium Perillae 8.
Particularly, the optimum ratio of the invention described above composition material medicine is:
Radix Bupleuri 10, Radix Scutellariae 10, the Rhizoma Pinelliae 10, Flos Inulae 10, Herba Schizonepetae 10, Radix Asteris 18, the Radix Stemonae 18, Rhizoma Cynanchi Stauntonii 18, Radix Platycodonis 18, Pericarpium Citri Reticulatae 10, Radix Glycyrrhizae 5, Folium Eriobotryae 18, Folium Perillae 10.
Particularly, the optimum ratio of the invention described above composition material medicine is:
Radix Bupleuri 10, Radix Scutellariae 10, the Rhizoma Pinelliae 10, Flos Inulae 10, Herba Schizonepetae 10, Radix Asteris 15, the Radix Stemonae 15, Rhizoma Cynanchi Stauntonii 15, Radix Platycodonis 15, Pericarpium Citri Reticulatae 10, Radix Glycyrrhizae 5, Folium Eriobotryae 15, Folium Perillae 10.
Particularly, the optimum ratio of the invention described above composition material medicine is:
Radix Bupleuri 8, Radix Scutellariae 8, the Rhizoma Pinelliae 10, Flos Inulae 10, Herba Schizonepetae 8, Radix Asteris 15, the Radix Stemonae 18, Rhizoma Cynanchi Stauntonii 15, Radix Platycodonis 18, Pericarpium Citri Reticulatae 8, Radix Glycyrrhizae 5, Folium Eriobotryae 15, Folium Perillae 10.
Preferably, the described Rhizoma Pinelliae is Rhizoma Pinelliae Preparatum.
Preferably, described Radix Glycyrrhizae is Radix Glycyrrhizae Preparata.
Get the traditional Chinese medicinal composition raw materials of the present invention by above-mentioned weight proportion, press pharmaceutics conventional method, add conventional adjuvant, be prepared into various, clinical acceptable dosage form, includes but not limited to a kind of in the middle of following dosage form: tablet, capsule, soft capsule, injection, pill, granule, suspensoid, drop pill or oral liquid etc.
The preparation method of preferred Chinese medicine composition of the present invention is that the part or all of crude drug of solvent extraction, concentrates, and removes impurity, after being dried, more according to a conventional method, adds conventional adjuvant, is prepared into various clinical acceptable dosage forms.Described solvent is preferably one or more of water, ethanol, acetone, chloroform, ethyl acetate, methanol.
The preparation method of preferred Chinese medicine composition of the present invention is, before solvent extraction, to containing the medical material of volatile oil, to extract volatile oil.Described extraction volatile oil is preferably steam distillation, supercritical extraction volatilization wet goods.
Preferably, the preparation technology of Chinese medicine composition of the present invention comprises the steps:
Get above crude drug, remove impurity and non-medicinal part, decoct with water 1-3 time, each 1-3 hour that decocts, collecting decoction, filter, decocting liquid is concentrated into 40-60 ℃ and surveys the clear paste that relative density is 1.05-1.15, room temperature to be chilled to, add ethanol make containing alcohol amount be 50-70%, stir evenly, cold preservation 24-72 hour, get supernatant, filter, filtrate recycling ethanol, be concentrated into the 45-60 ℃ of extractum of surveying relative density 1.20-1.40, get extractum, through conventional operation, directly or indirectly add pharmaceutically acceptable excipient to make clinical acceptable dosage form, as tablet, capsule, soft capsule, injection, pill, granule, suspensoid, drop pill or oral liquid etc.
Preferably, before boiling, decocting adds volatile oil extraction step.Preferred, by volatile oil with after cyclodextrin inclusion compound for the preparation of various clinical acceptable dosage forms.
Preferably, the preparation technology of Chinese medicine composition of the present invention comprises the steps:
Get the invention described above traditional Chinese medicinal composition raw materials, by 3～7 times of amount 30～90% ethanol heating extraction 2～4 times, each 0.5～2 hour, filter merging filtrate; Decompression recycling ethanol, being concentrated into relative density is 1.15～1.20 fluid extracts; Add water and make every 1ml containing the solution that is equivalent to 0.5g medical material, stir evenly, standing 48 hours, filter; Filtrate, by macroporous resin column, first washes with water; Discard water lotion, then use 30～95% ethanol elutions, merge alcoholic solution; Concentrating under reduced pressure, vacuum drying, obtains the dry extract of Chinese medicine composition of the present invention; Get the dry extract of Chinese medicine composition of the present invention, add conventional adjuvant, preparation process or step, make clinical acceptable tablet, capsule, soft capsule, injection, pill, granule, suspensoid, drop pill or oral liquid etc. routinely.
Preferably, before ethanol extraction, add volatile oil extraction step.Preferred, by volatile oil with after cyclodextrin inclusion compound for the preparation of various clinical acceptable dosage forms.
Meanwhile, the present invention also provides described Chinese medicine composition for the preparation of the application in treatment medicament for treating respiratory system thing.
Preferably, described Chinese medicine composition is for the preparation of the application in treatment pulmonary disease medicine.
Preferably, described Chinese medicine composition is for the preparation of the application in treatment respiratory tract disease medicine.
Preferably, described Chinese medicine composition is for the preparation of the application in treatment upper respiratory disease medicine.
Preferably, described Chinese medicine composition is for the preparation of the application in treatment cough medicine.
Through experimentation and deep clinical verification widely, inventor finds that above-mentioned Chinese medicine composition is very suitable for respiratory system disease patient instantly, and described not only comprises environmental factors but also comprise patient body quality factor instantly.Compare with original similar medicine or classical prescription, above-mentioned Chinese medicine composition has unforeseeable technique effect.
Certainly, the treatment theory based on the traditional Chinese medical science, principle and treatment practice, those skilled in the art may strengthen therapeutic effect according to the different part material medicines that increase of concrete patient's the state of an illness.The inventor has passed through a large amount of research, has obtained basic increase principle, specific as follows:
1 wind-cold affecting lung: expelling wind and cold, lung qi dispersing cough-relieving.Above-mentioned Chinese medicine composition adds Herba Ephedrae, Semen Armeniacae Amarum, forms three stubborn Zhisou San.
2 wind-heat invading the lung: wind and heat dispersing, lung qi dispersing cough-relieving.Above-mentioned Chinese medicine composition goes the Pericarpium Citri Reticulatae of warm-dryness syndrome to add Folium Mori, Flos Chrysanthemi, Fructus Forsythiae, Herba Menthae, Semen Armeniacae Amarum, forms Sang Ju Yin Zhisou San.
3 pathogenic dryness impairing the lung: dispelling wind lung heat clearing, moisten dryness and relieve cough.Above-mentioned Chinese medicine composition goes the Pericarpium Citri Reticulatae of warm-dryness syndrome to add Folium Mori, Semen Armeniacae Amarum, Fructus Gardeniae, Radix Adenophorae (Radix Glehniae), Bulbus Fritillariae Cirrhosae composition Mulberry Fructus Pruni Zhisou San.
4 phlegm-heat obstructing in the lungs: removing heat-phlegm, eliminating the pathogens from the lung cough-relieving.Above-mentioned Chinese medicine composition goes the table of Herba Schizonepetae loose, and the warm-dryness syndrome of Pericarpium Citri Reticulatae adds Cortex Mori, Cortex Lycii or adds Radix Scutellariae, Rhizoma Coptidis, Radix Et Rhizoma Rhei composition SANHUANG purging pathogenic fire of the lung Zhisou San.
5 liver-fire invading the lungs: heat clearing away eliminating pathogen in the liver, pleasant pathogenic fire reducing.Above-mentioned Chinese medicine composition goes the table of Herba Schizonepetae loose, and the warm-dryness syndrome of Pericarpium Citri Reticulatae adds Indigo Naturalis, sea clam powder forms black pigment used by women in ancient times to paint their eyebrows clam Zhisou San.
6 phlegm dampness in lungs: drying dampness to eliminate phlegm, sending down the abnormal ascending QI cough-relieving.Above-mentioned Chinese medicine composition goes the table of Herba Schizonepetae loose, adds the Rhizoma Pinelliae, Poria, Semen Sinapis Albae, Fructus Perillae, Semen Raphani and forms two old three sub-Zhisou San.
7 lung yin virtual loss: nourishing YIN and moistening the lung, relieving cough and resolving phlegm.Above-mentioned Chinese medicine composition goes the table of Herba Schizonepetae loose, and the warm-dryness syndrome of Pericarpium Citri Reticulatae adds Radix Asparagi, Radix Ophiopogonis, the Rhizoma Anemarrhenae, the female Zhisou San of Bulbus Fritillariae Cirrhosae composition Radix Asparagi and Radix Ophiopogonis two.
8 lung qi virtual loss: QI invigorating tonifying the lung.Above-mentioned Chinese medicine composition goes the table of Herba Schizonepetae loose, and the warm-dryness syndrome of Pericarpium Citri Reticulatae adds the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae composition jade screen Zhisou San
Certainly, those skilled in the art know that can be with the above-mentioned concrete crude drug that substitutes of the crude drug of other similar functions, and still, the technique effect of testing generation through inventor will can more not be better than above-mentioned raw materials medicine.
Crude drug of the present invention is described below:
Radix Bupleuri is generally root or the herb of Umbelliferae herbaceos perennial Radix Bupleuri (Radix Bupleuri) and Radix Bupeuri Scorzonerfolii. (Radix Bupleuri Scorzonerifolii).The former main product in Liaoning, Gansu; The latter's main product is in Hubei, Jiangsu and other places.Nature and flavor are bitter, pungent, be slightly cold.Effect reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.For alternate attack of chill and fever, feeling of fullness and disecomfort in the chest and hypochondrium, bitter taste, or distending pain in the chest and hypochondrium, menoxenia, or the card of the collapse of QI such as proctoptosis, uterine prolapse.
Radix Scutellariae is generally the root of Labiatae herbaceos perennial Radix Scutellariae.Main product is in Hebei, Shanxi and other places.Nature and flavor are bitter, cold.Return lung, gallbladder, stomach warp.Effect heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For the multiple disease due to warm, as hygropyrexia, jaundice, dysentery, carbuncle sore tumefacting virus etc., or for damp-heat disease high fever excessive thirst, yellow fur rapid pulse, or for cough due to lung-heat, also can be used for excessive fetal movement due to heat in pregnancy.
The Rhizoma Pinelliae is generally the tuber of the Araeceae herbaceos perennial Rhizoma Pinelliae.Main product is in the Yangtze river basin.Nature and flavor are pungent, warm, poisonous.Return spleen, stomach, lung meridian.Effect drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For not removing dampness of spleen, sputum, stop up the diseases such as abundant expectoration due to stagnant, cough, QI rising in reverse order, also can be used for the nausea and vomiting of adverse rising of stomach-QI
Flos Inulae is generally the head inflorescence of feverfew Flos Inulae Inula japonica Thunb..Main product Henan, Jiangsu, Hebei, Zhejiang, Anhui and various places, northeast.Bitter, pungent, one-tenth, tepor.Enter lung, liver, stomach warp.Eliminating phlegm to relieve asthma, lowering the adverse flow of QI.Control cough with asthma abundant expectoration, singultus, eructation, vomiting.Decoction: 4.5～9 grams, decoct a drug wrapped.This product is containing inulin, Flos Caryophylli convolvicine, Quercetin, isoquercitin, inusterol A, B, C and inulin.Flavone have in animals weak relieving asthma, diuresis.
Herba Schizonepetae is generally the herb of labiate Herba Schizonepetae Schizonepeta tenuifolia (Benth.) Briq..The ground such as main product Jiangsu, Zhejiang, Jiangxi, Hubei, Hebei.Pungent, temperature.Enter lung, Liver Channel.Induce sweat, dispel the wind, hemostasis, sore disappears.1. the heating that cures cold, headache nasal obstruction; Cough, laryngopharynx swelling and pain; Measles is sent out not smooth thoroughly, urticaria.2. control haematemesis, epistaxis, has blood in stool, metrorrhagia, puerperal blood faints.3. control carbuncle, scabies scrofula.Decoction: 4.5～9 grams.Solution hypergene use, hemostasis parch to black is used.Spica name Herba Schizonepetae, function is identical with Herba Schizonepetae, and it is stronger to disperse strength.Herb is containing volatile oil, and main component is D-menthone, d-limonen, left-handed pulegone etc.Decoct can suppress tubercule bacillus in vitro.Fry after black one-tenth charcoal, can make bleeding time and clotting time shorten.
Radix Asteris is generally the root and rhizome of feverfew Radix Asteris Aster tataricus L.f..The ground such as main product Hebei, Anhui.Hardship, temperature.Enter lung meridian.Preventing phlegm from forming and stopping coughing.Control cough and asthma, cough up phlegm not well.Decoction: 3～9 grams.This product is containing epifriedelanol, freidelin, shionon, astersaponin, Quercetin and volatile oil.Decoct to mice, rabbit eliminate the phlegm, antitussive action, in vitro to staphylococcus aureus, dysentery, distortion, typhoid fever, paratyphoid fever, large intestine and bacillus pyocyaneus all have inhibitory action, infected by influenza also has obvious inhibitory action.Epifriedelanol has antitumaous effect to ehrlich carcinoma.
The Radix Stemonae is generally the tuber of Stemonaceae plant Radix stemonae japonicae Stemona japonica (Blume) Miq. or Radix Stemonae S.sessilifolia (Miq.), radix stemonae tuberosae S.tuberosa Lour..The Radix Stemonae, Radix Stemonae main product East China; Radix stemonae tuberosae main product Hubei, Sichuan, Guangxi, Yunnan.Sweet, bitter, tepor.Slightly poisonous.Enter lung meridian.Lung moistening, cough-relieving, parasite killing.1. control pulmonary tuberculosis, bronchitis, pertussis.Decoction: 3～9 grams, processed with honey is used.2. control enterobiasis, with 30 grams of raw product, take dope, the previous crops retention enema of sleeping; Kill head louse, body louse, steeping in wine liquid or decocting liquid are coated with and put on the skin.This product is containing multiple alkaloid.(-)-Stemoninine can reduce the irritability of respiratory center, contributes to suppress coughre flex.Decoct and ethanol preserved material are to Fructus Vitis viniferae, streptococcus pneumoniae, and tuberculosis, diphtheria, bacillus pyocyaneus and various skin fungus all have inhibitory action.Effective to experimental tuberculosis.The Radix Stemonae has certain preventive and therapeutic action to infecting the mice of Asia influenza A virus.The correct louse of alcohol preserved material, body louse, pubic louse, Cimex bedbug, pinworm, trichomonas vaginitis all have killing action.
Rhizoma Cynanchi Stauntonii is generally the root and rhizome of asclepiadaceae plant rhizoma et radix cynanchi stauntoni Cynanchum stauntonii (Decne.) schltr.exLevl. or leaves of Daphne genkwa Rhizoma Cynanchi Stauntonii C.glaucescens (Decne.) Hand.-Mazz..Main product Zhejiang, Anhui.Pungent, sweet, tepor.Enter lung meridian.Sending down the abnormal ascending QI, eliminates the phlegm.Control lung qi and stop up the cough ant phlegm of reality, dyspnea due to adverseness of QI.Decoction: 6～9 grams.Leaves of Daphne genkwa Rhizoma Cynanchi Stauntonii is containing triterpenoid saponin.
Radix Platycodonis is generally the root of Campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A.DC..Main product Anhui, Jiangsu, Hebei, Henan, Hubei, Liaoning, Jilin, the Inner Mongol.Bitter, pungent, flat.Enter lung meridian.Lung qi dispersing, eliminates the phlegm, sore-throat relieving, evacuation of pus.Control exogenous cough, abundant expectoration is not well, laryngopharynx swelling and pain, and hoarseness, fullness in the chest painful abdominal mass is vexed, and lung abscess is coughed vomiting bloody pus.Decoction: 3～9 grams.This product is containing multiple kikyosaponin, plant sterol, platycodonin, platycogenic acid etc.Orally can stimulate gastric mucosa, reflexive causes bronchus body of gland secretion increasing and plays phlegm-dispelling functions.Water or alcohol extract can reduce rabbit blood glucose.Water logging agent can suppress acrothesium floccosum in vitro.
Pericarpium Citri Reticulatae is generally the mature peel of the sub-magaphanerophytes of Rutaceae tangerine.Nature and flavor are bitter, pungent, temperature.Contain the compositions such as volatile oil, hesperidin, vitamin (C, B).There is circulation of qi promoting spleen invigorating, drying dampness to eliminate phlegm, the effect of stopping nausea and vomiting by lowering the adverse flow of QI.Be applicable to distension and fullness in the abdomen, belch, vomiting, cough, the diseases such as excessive phlegm.
Radix Glycyrrhizae is generally root and the rhizome of glycyrrhizic legume Gly-cyrrhiza uralens is Fisch..The ground such as the main product Inner Mongol, Gansu.Sweet, flat.Enter spleen, lung meridian.Spleen reinforcing stomach function regulating, relieving spasm to stop pain, expelling phlegm for arresting cough, removing toxic substances, coordinating the actions of various ingredients in a prescription.Control weakness of the spleen and stomach, epigastric pain, cough, cardiopalmus, laryngopharynx swelling and pain, skin infection, poisoning.Also be used for the treatment of hypocorticoidism disease modern age.Radix Glycyrrhizae Preparata slightly warm in nature, is used for deficiency syndrome, cold syndrome.Decoction: 1.5～9 grams.The anti-Radix Euphorbiae Pekinensis, Flos Genkwa, Radix Kansui, Sargassum.This product is containing glycyrrhizic acid, enoxolone.Extractum has protective effect to Experimental Gastric Ulcer in Rats, and decoct can suppress intestine in vitro.Extractum, glycyrrhizin, enoxolone have and promote sodium, water retention effect and cause edema, hypertension.Enoxolone tool antiinflammatory, glycyrrhizin tool anti-allergic effects.Radix Glycyrrhizae tool antitussive effect, the rats'liver that carbon tetrachloride is caused infringement has protective effect.Extractum and glycyrrhizin have certain Detoxication to some poisonous substance; The latter can reduce cholesterolemia and increase bile secretion.
Folium Eriobotryae is generally the leaf of rosaceous plant Folium Eriobotryae Eriobotrya japonica (Thunb.) Lindl..The ground such as main product Guangdong, Jiangsu, Zhejiang, Fujian, Hubei.Hardship, flat.Enter lung, stomach warp.Clearing away lung-heat to relieve cough, regulating the stomach and sending down the abnormal ascending QI.Control lung-heat cough with asthma, spitting of blood, epistaxis, gastropyretic vomiting, singultus.Decoction: 4.5～9 grams, use brushes the hair of herbs.Leaf is containing Saponin, ursolic acid, amygdalin, tannin etc.Fresh leaf is containing volatile oil.Decoct has inhibitory action to staphylococcus aureus.Semen Armeniacae Dulcis bar is shown in amygdalin effect.
Folium Perillae is generally the leaf of labiate wrinkle Folium Perillae Perilla frutescens (L.) Brit t.var.crispa (Thunb.) Decne. or sharp Folium Perillae P.frutescens (L.) Brit t.var acuta (Thunb.) Kudo etc.The ground such as main product Jiangsu, Hubei, Guangdong.Pungent, temperature.Enter lung, spleen channel.Deliver cold expelling, regulating the flow of QI to ease the stomach, antiabortive, separate fish, Eriocheir sinensis poison.1. control anemofrigid cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen.Pregnancy reactions, frequent fetal movement.2. control the vomiting and diarrhoea causing after ichthyophagy, Eriocheir sinensis, stomachache.Decoction: 6～9 grams.This product is containing volatile oil, and oil includes perillaldehyde, limonene, pinene etc.Decoct or preserved material have weak refrigeration function to artificial fever rabbit; In vitro staphylococcus is had to inhibitory action.The perilla oil rabbit blood glucose that can raise.
Described Chinese medicine composition prescription is gentle, has stronger relieving cough and resolving phlegm effect, outer dispelling wind to relieve the exterior syndrome, interior pleasant reducing phlegm, the respiratory system disease that different reasons are caused, particularly cough all have good therapeutical effect, no matter wind-heat cough or affection of exogenous wind-cold cough, or endogenous cough.On the basis of the above-mentioned principles of formulating prescriptions, one of ordinary skill in the art can carry out conventional replacement, minimizing and/or increase according to general knowledge.
The specific embodiment
Following embodiment is only explanation of the invention, rather than to concrete restriction of the present invention.
Embodiment 1
Radix Bupleuri 12g, Radix Scutellariae 12g, Rhizoma Pinelliae Preparatum 12g, Flos Inulae 12g, Herba Schizonepetae 12g, Radix Asteris 18g, Radix Stemonae 18g, Rhizoma Cynanchi Stauntonii 18g, Radix Platycodonis 18g, Pericarpium Citri Reticulatae 12g, Radix Glycyrrhizae Preparata 7g, Folium Eriobotryae 18g, Folium Perillae 12g
Get above crude drug, remove impurity and non-medicinal part, extract volatile oil, volatile oil cyclodextrin inclusion compound, standby.Decoct with water again 2 times, decoct collecting decoction at every turn 2 hours, filter, decocting liquid is concentrated into 40-60 ℃ and surveys the clear paste that relative density is 1.05-1.15, room temperature to be chilled to, add ethanol and make to be 50-70%, to stir evenly cold preservation 24-72 hour containing alcohol amount, get supernatant, filter, filtrate recycling ethanol, is concentrated into the 45-60 ℃ of extractum of surveying relative density 1.20-1.40, get extractum and volatile oil, through conventional operation, directly or indirectly add pharmaceutically acceptable excipient to make capsule.
Embodiment 2
Radix Bupleuri 8g, Radix Scutellariae 8g, Rhizoma Pinelliae 8g, Flos Inulae 8g, Herba Schizonepetae 8g, Radix Asteris 13g, Radix Stemonae 13g, Rhizoma Cynanchi Stauntonii 13g, Radix Platycodonis 13g, Pericarpium Citri Reticulatae 8g, Radix Glycyrrhizae 3g, Folium Eriobotryae 18g, Folium Perillae 12g
Get above crude drug, remove impurity and non-medicinal part, decoct with water 3 times, each decoction 1.5 hours, collecting decoction, filters, and decocting liquid is concentrated into 40-60 ℃ and surveys the clear paste that relative density is 1.05-1.15, room temperature to be chilled to, add ethanol and make to be 50-70%, to stir evenly cold preservation 24-72 hour containing alcohol amount, get supernatant, filter, filtrate recycling ethanol, is concentrated into the 45-60 ℃ of extractum of surveying relative density 1.20-1.40, get extractum, through conventional operation, directly or indirectly add pharmaceutically acceptable excipient to make oral liquid.
Embodiment 3
Radix Bupleuri 12g, Radix Scutellariae 12g, Rhizoma Pinelliae Preparatum 12g, Flos Inulae 12g, Herba Schizonepetae 8g, Radix Asteris 13g, Radix Stemonae 13g, Rhizoma Cynanchi Stauntonii 13g, Radix Platycodonis 13g, Pericarpium Citri Reticulatae 8g, Radix Glycyrrhizae 3g, Folium Eriobotryae 13g, Folium Perillae 8g
Get above crude drug, remove impurity and non-medicinal part, extract volatile oil, standby.Decoct with water again 3 times, decoct collecting decoction at every turn 1.5 hours, filter, decocting liquid is concentrated into 40-60 ℃ and surveys the clear paste that relative density is 1.05-1.15, room temperature to be chilled to, add ethanol and make to be 50-70%, to stir evenly cold preservation 24-72 hour containing alcohol amount, get supernatant, filter, filtrate recycling ethanol, is concentrated into the 45-60 ℃ of extractum of surveying relative density 1.20-1.40, get extractum and volatile oil, through conventional operation, directly or indirectly add the agent of pharmaceutically acceptable excipient granulation.
Embodiment 4
Radix Bupleuri 8g, Radix Scutellariae 8g, Rhizoma Pinelliae 10g, Flos Inulae 10g, Herba Schizonepetae 8g, Radix Asteris 15g, Radix Stemonae 18g, Rhizoma Cynanchi Stauntonii 15g, Radix Platycodonis 18g, Pericarpium Citri Reticulatae 8g, Radix Glycyrrhizae 5g, Folium Eriobotryae 15g, Folium Perillae 10g
Get the invention described above traditional Chinese medicinal composition raw materials, by 5 times of amount 60% ethanol heating extraction 3 times, each 1 hour, filter merging filtrate; Decompression recycling ethanol, being concentrated into relative density is 1.15～1.20 fluid extracts; Add water and make every 1ml containing the solution that is equivalent to 0.5g medical material, stir evenly, standing 48 hours, filter; Filtrate, by macroporous resin column, first washes with water; Discard water lotion, then use 70% ethanol elution, merge alcoholic solution; Concentrating under reduced pressure, vacuum drying, obtains the dry extract of Chinese medicine composition of the present invention; Get the dry extract of Chinese medicine composition of the present invention, add conventional adjuvant, preparation process or step, make injection routinely.
Embodiment 5
Radix Bupleuri 10g, Radix Scutellariae 10g, Rhizoma Pinelliae Preparatum 10g, Flos Inulae 10g, Herba Schizonepetae 10g, Radix Asteris 15g, Radix Stemonae 15g, Rhizoma Cynanchi Stauntonii 15g, Radix Platycodonis 15g, Pericarpium Citri Reticulatae 10g, Radix Glycyrrhizae 5g, Folium Eriobotryae 15g, Folium Perillae 10g
Get above crude drug, remove impurity and non-medicinal part, decoct with water 3 times, each decoction 1.5 hours, collecting decoction, filters, and decocting liquid is concentrated into the 45-60 ℃ of extractum of surveying relative density 1.20-1.40, get extractum, through conventional operation, directly or indirectly add pharmaceutically acceptable excipient to make oral liquid.
Embodiment 6
Radix Bupleuri 8g, Radix Scutellariae 8g, Rhizoma Pinelliae 8g, Flos Inulae 8g, Herba Schizonepetae 8g, Radix Asteris 15g, Radix Stemonae 15g, Rhizoma Cynanchi Stauntonii 15g, Radix Platycodonis 15g, Pericarpium Citri Reticulatae 8g, Radix Glycyrrhizae Preparata 3g, Folium Eriobotryae 15g, Folium Perillae 8g
Get the invention described above traditional Chinese medicinal composition raw materials, by 7 times of amount 60% ethanol heating extraction 2 times, each 2 hours, filter merging filtrate; Decompression recycling ethanol, being concentrated into relative density is 1.15～1.20 fluid extracts; Add water and make every 1ml containing the solution that is equivalent to 0.5g medical material, stir evenly, standing 24 hours, filter; Filtrate, by macroporous resin column, first washes with water; Discard water lotion, then use 40% ethanol elution, merge alcoholic solution; Concentrating under reduced pressure, vacuum drying, obtains dry extract; Get dry extract, add conventional adjuvant, preparation process or step, make soft capsule routinely.
Embodiment 7
Radix Bupleuri 10g, Radix Scutellariae 10g, Rhizoma Pinelliae Preparatum 10g, Flos Inulae 10g, Herba Schizonepetae 10g, Radix Asteris 18g, Radix Stemonae 18g, Rhizoma Cynanchi Stauntonii 18g, Radix Platycodonis 18g, Pericarpium Citri Reticulatae 10g, Radix Glycyrrhizae Preparata 5g, Folium Eriobotryae 18g, Folium Perillae 10g
Get above crude drug, remove impurity and non-medicinal part, extract volatile oil, standby.Decoct with water again 3 times, decoct collecting decoction at every turn 1.5 hours, filter, decocting liquid is concentrated into 40-60 ℃ and surveys the clear paste that relative density is 1.05-1.15, room temperature to be chilled to, add ethanol and make to be 50-70%, to stir evenly cold preservation 24-72 hour containing alcohol amount, get supernatant, filter, filtrate recycling ethanol, is concentrated into the 45-60 ℃ of extractum of surveying relative density 1.20-1.40, get extractum and volatile oil, through conventional operation, directly or indirectly add pharmaceutically acceptable excipient to make tablet.
Experimental example
Through experiment present composition preparation (embodiment 1), there is the effects such as antibiosis and antiviral functions, antiinflammatory refrigeration function and analgesia.
Result is:
(1) In vitro Bactericidal Experiments (carry out according to this area normal experiment method, can with reference to < < pharmacology > > textbook): the present composition is to escherichia coli, staphylococcus aureus, blue pus organism, α-hemolytic streptococcus, beta hemolytic streptococcus, streptococcus pneumoniae, Neisseria meningitidis, hemophilus influenza, Klebsiella Pneumoniae, the minimal inhibitory concentration of the type strain of saccharomyces albicans (MIC) and minimal bactericidal concentration (MBC) scope are respectively 0.049～0.63g crude drug/ml and 0.16～2.50g crude drug/ml, to clinical separation strain (golden yellow Portugal bacterium, A type chain bacterium, B-mode chain bacterium, streptococcus pneumoniae, klebsiella, hemophilus influenza) MIC and MBC scope are respectively 0.019～0.32g crude drug/ml and 0.079～0.32g crude drug/ml, show, the present composition is to testing 10 selected strain reference cultures and 430 selected strain clinical isolates strains all have certain inhibition and deactivation.
(2) extracorporeal antivirus effect test (is carried out according to this area normal experiment method, can be with reference to < < pharmacology > > textbook): when result shows present composition leachate 0.13～1g crude drug/ml, adenovirus type III is had to the more tetanic deactivation that connects, its MIC is 0.069g crude drug/ml, IC50 is 0.095g crude drug/ml, and IC90 is 0.14g crude drug/ml; Liquor strength has inhibitory action (P<0.05) to adenovirus type III cytopathogenic effect when 1～0.5g crude drug/ml, can suppress the propagation (P<0.05) of influenza virus PR8 strain in Embryo Gallus domesticus during present composition leachate 1g crude drug/ml.
(3) (carry out according to this area normal experiment method analgesic test, can be with reference to < < pharmacology > > textbook): result shows that the present composition can make the thermostimulation threshold of pain improve, can make writhing significant prolongation incubation period, writhing number of times obviously reduces, and illustrates that the present composition has obvious analgesic activity.In antiinflammatory test, 22.3g crude drug/kg group can effectively suppress capillary permeability; Experimental result to rat paw edema due to Ovum Gallus domesticus album shows, present composition 18g crude drug/kg group is made comparisons with model group, can reduce pedal swelling percentage rate, illustrates that it has antiinflammatory action.
(4) separating heat test (carries out according to this area normal experiment method, can be with reference to < < pharmacology > > textbook): result shows 4.5g crude drug/kg, 9g crude drug/kg, the fervescence value of 3 dosage groups of 18g crude drug/kg group is starkly lower than model group, shows that the present composition has significant refrigeration function.
Antitussive test
The present composition can obviously extend citric acid and cause guinea pig cough's incubation period and obviously reduce the number of times that citric acid causes guinea pig cough, obviously reduces the number of times that strong aqua ammonia causes mouse cough.
Citric acid is caused to the impact of guinea pig cough's incubation period and cough number of times:
Test grouping and dosage:
(1) model group: 0.5%CMC-Na solution.(2) positive drug group: carbetapentane citrate suspension solution (0.025g/kg).(3) Zhisou San group: suspension solution (5g/kg).(4) Zhisou San+Folium Eriobotryae: suspension solution (5g/kg).(5) Zhisou San+Rhizoma Pinelliae group: suspension solution (10g/kg).(6) Zhisou San+Radix Scutellariae group: suspension solution (10g/kg).(7) Zhisou San+Radix Bupleuri group: suspension solution (10g/kg).(8) Zhisou San+Flos Inulae: suspension solution (10g/kg).(9) Zhisou San+Folium Perillae: suspension solution (10g/kg).(10) embodiment of the present invention is 3 groups: suspension solution (10g/kg).(11) embodiment of the present invention is 7 groups: suspension solution (10g/kg).Administration volume: 10ml/kg.Route of administration: oral administration gavage administration (ig).Above-mentioned (3)-(9) group Raw medicine weight proportion relation is in the same manner as in Example 7, and difference is to lack part material medicine.
Test operation:
Get healthy trichroism Cavia porcellus, male and female half and half, body weight 180～200g, is placed in Cavia porcellus respectively in the airtight lucite experimental box of 20 * 20 * 15cm 1, each every case.17.5% citric acid soln 50ml is placed in to atomization in soniclizer, in experimental box, lead to atomization citric acid soln 30 seconds, record self-spray and play guinea pig cough's number of times in 5 minutes (cough is opened one's mouth with Cavia porcellus and heard that the loud sound of coughing is for once cough), lower than 10 persons, will not select.Choose 110 of qualified Cavia porcelluss, be divided at random 11 groups, model group, positive drug group etc. are above-mentioned 11 groups, and 10 every group, male and female half and half.Every day, ig administration was 1 time, for three days on end.After last administration 1 hour, Cavia porcellus is placed in respectively in the airtight lucite experimental box of 20 * 20 * 15cm again to 1, each every case.17.5% citric acid soln 50ml is placed in to atomization in soniclizer, in experimental box, lead to atomization citric acid soln 30 seconds, record cough latent period and self-spray and play guinea pig cough's number of times in 5 minutes, and between employing group, t method of inspection and model group are carried out significance test comparison.
Result of the test:
Result demonstration, Chinese medicine composition of the present invention can obviously extend citric acid and cause guinea pig cough's incubation period, obviously reduces the number of times that citric acid causes guinea pig cough, learns and processes by statistics, compares with model group, has significant.And, (10) and (11) group relatively can find out with (3)-(9) groups, by after Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae Preparatum, Flos Inulae, Folium Eriobotryae and Folium Perillae and Zhisou San combination, produced obvious synergism, obviously the result that is better than other groups, even their simple superposition effect.The results are shown in Table 1.
Table 1: the impact on guinea pig cough's incubation period and number of times thereof
Ammonia is caused to the impact of mouse cough number of times:
Get ICR mice, body weight 19～21g, is divided into 9 groups at random, i.e. model group, carbetapentane citrate positive drug group, embodiment 1-7 group, 10 every group, male and female half and half.Every day, ig administration was 1 time, for three days on end.After last administration 1 hour, each Mus is placed in respectively in the airtight lucite experimental box of 20 * 20 * 15cm to 1, each every case.Strong aqua ammonia 50ml is placed in to atomization in soniclizer, in experimental box, lead to atomized ammonia 20 seconds, record self-spray and play mouse cough number of times in 5 minutes (cough is shunk and to be magnified mouth for once coughing simultaneously with mice abdominal muscle), and between employing group, t method of inspection and model group are carried out significance test comparison.
Result of the test:
Result shows that embodiment 1-7 all can obviously reduce strong aqua ammonia is caused to mouse cough number of times, learns and processes by statistics, compares with model group, has significant.
Table 2: strong aqua ammonia is caused to the impact of mouse cough number of times
Clinical experiment example
50 routine patients all meet the standard of the diagnosis cough of Department of Medical Administration of State Administration of Traditional Chinese Medicine formulation, have got rid of the cough that organic disease causes, above-mentioned case is divided into 5 groups at random, every group of 10 people, contrast medicine group, 1 group of embodiment, 3 groups of embodiment, 5 groups of embodiment, 7 groups of embodiment.Male 28 examples wherein, female's 22 examples, the age is 20～55 years old, 1～6 day person's 15 example of the course of disease, 7 days-March person's 15 examples, April-1 year person 11 examples, 1.0～4.5 years person's 9 examples.Cough 19 examples that upper respiratory tract infection and acute bronchitis cause, cough 18 examples that chronic bronchitis causes, cough 10 examples that pharyngolaryngitis etc. cause, cough 3 examples that other diseases causes.Chinese medical discrimination belongs to wind-cold affecting lung person's 15 examples, wind-heat invading the lung person's 13 examples, insufficiency of the spleen phlegm-damp person 10 examples, lung yin virtual loss person 12 examples.
Experimental agents
Contrast medicine group: contrast medicine group patient gives Zhisou San
1 group of medicine group: embodiment gives embodiment 1 medicine, and 3 groups of embodiment give embodiment 3 medicines, and 5 groups of embodiment give embodiment 5 medicines, and 7 groups of embodiment give embodiment 7 medicines
Medication course for the treatment of
Said medicine equal every day twice, gives dose identical, is all equivalent to 60g crude drug/sky/people.Continuous use is observed 7 days.
Criterion of therapeutical effect
The cough criterion of therapeutical effect of formulating in October, 1998 with reference to Department of Medical Administration of State Administration of Traditional Chinese Medicine, and in conjunction with the clinical experience of oneself, determine following standard:
Cure: the symptoms such as cough, sign disappear, and the lab testings such as hemocyte are normal;
Take a turn for the better: symptom, the signs such as cough alleviate, the lab testings such as hemocyte approach normal;
Invalid: the lab testings such as symptom, sign and hemocyte such as cough are unchanged or increase the weight of.
Result
In Table 3.
Table 3: clinical test results
| Group | Patient's number | Cure | Take a turn for the better | Invalid | Total effective rate |
| Matched group | 10 | 3 | 2 | 5 | 50％ |
| 1 group of embodiment | 10 | 6 | 4 | 0 | 100％ |
| 3 groups of embodiment | 10 | 6 | 4 | 0 | 100％ |
| 5 groups of embodiment | 10 | 7 | 3 | 0 | 100％ |
| 7 groups of embodiment | 10 | 7 | 3 | 0 | 100％ |
Known from the above results obtaining giving identical dose, due to various environment or physical factors, Zhisou San significant discomfort for the treatment of modern cough, and Chinese medicine composition deposits yields of the present invention unexpected technique effect.
Model case
Soup so-and-so, man, student, in JIUYUE, 2013 is medical.Main suit coughs 7 days.Patient suffers from cold accidentally, aversion to cold, and heating, systemic pain, all diseases are increased the weight of, and cough, cough up phlegm, and here is medical then.Card is shown in: coughs low voice speaking, and thin and whitish sputum, pharyngitis, light red tongue, white and thin fur, tense pulse.Chinese medical discrimination: cough (syndrome of wind-cold attacking lung).Use embodiment 1 medicine, recovery from illness in 7 days.
Claims (10)
1. treat a Chinese medicine composition for respiratory system disease, it is characterized in that being made by the crude drug of following weight proportion:
Radix Bupleuri 8-12, Radix Scutellariae 8-12, Rhizoma Pinelliae 8-12, Flos Inulae 8-12, Herba Schizonepetae 8-12, Radix Asteris 13-18, Radix Stemonae 13-18, Rhizoma Cynanchi Stauntonii 13-18, Radix Platycodonis 13-18, Pericarpium Citri Reticulatae 8-12, Radix Glycyrrhizae 3-7, Folium Eriobotryae 13-18, Folium Perillae 8-12.
2. Chinese medicine composition as claimed in claim 1, is characterized in that being made by the crude drug of following weight portion:
Radix Bupleuri 8-10, Radix Scutellariae 8-10, Rhizoma Pinelliae 8-10, Flos Inulae 8-10, Herba Schizonepetae 8-10, Radix Asteris 15-18, Radix Stemonae 15-18, Rhizoma Cynanchi Stauntonii 15-18, Radix Platycodonis 15-18, Pericarpium Citri Reticulatae 8-10, Radix Glycyrrhizae 3-5, Pi is than rake leaf 15-18, Folium Perillae 8-10.
3. Chinese medicine composition as claimed in claim 2, is characterized in that being made by the crude drug of following weight portion:
Radix Bupleuri 8, Radix Scutellariae 8, the Rhizoma Pinelliae 8, Flos Inulae 8, Herba Schizonepetae 8, Radix Asteris 15, the Radix Stemonae 15, Rhizoma Cynanchi Stauntonii 15, Radix Platycodonis 15, Pericarpium Citri Reticulatae 8, Radix Glycyrrhizae 3, Folium Eriobotryae 15, Folium Perillae 8.
4. Chinese medicine composition as claimed in claim 2, is characterized in that being made by the crude drug of following weight portion:
Radix Bupleuri 10, Radix Scutellariae 10, the Rhizoma Pinelliae 10, Flos Inulae 10, Herba Schizonepetae 10, Radix Asteris 18, the Radix Stemonae 18, Rhizoma Cynanchi Stauntonii 18, Radix Platycodonis 18, Pericarpium Citri Reticulatae 10, Radix Glycyrrhizae 5, Folium Eriobotryae 18, Folium Perillae 10.
5. Chinese medicine composition as claimed in claim 2, is characterized in that being made by the crude drug of following weight portion:
Radix Bupleuri 10, Radix Scutellariae 10, the Rhizoma Pinelliae 10, Flos Inulae 10, Herba Schizonepetae 10, Radix Asteris 15, the Radix Stemonae 15, Rhizoma Cynanchi Stauntonii 15, Radix Platycodonis 15, Pericarpium Citri Reticulatae 10, Radix Glycyrrhizae 5, Folium Eriobotryae 15, Folium Perillae 10.
6. Chinese medicine composition as claimed in claim 2, is characterized in that being made by the crude drug of following weight portion:
Radix Bupleuri 8, Radix Scutellariae 8, the Rhizoma Pinelliae 10, Flos Inulae 10, Herba Schizonepetae 8, Radix Asteris 15, the Radix Stemonae 18, Rhizoma Cynanchi Stauntonii 15, Radix Platycodonis 18, Pericarpium Citri Reticulatae 8, Radix Glycyrrhizae 5, Folium Eriobotryae 15, Folium Perillae 10.
7. the Chinese medicine composition as described in as arbitrary in claim 1-6, is characterized in that: the described Rhizoma Pinelliae is that Rhizoma Pinelliae Preparatum and/or described Radix Glycyrrhizae are Radix Glycyrrhizae Preparatas.
8. prepare as arbitrary in claim 1-6 as described in the method for Chinese medicine composition, it is characterized in that: the part or all of crude drug of solvent extraction, concentrated, remove impurity, after being dried, more according to a conventional method, add conventional adjuvant, be prepared into various clinical acceptable dosage forms.
9. the arbitrary described Chinese medicine composition of claim 1-6 is in the application for the preparation of in treatment medicament for treating respiratory system thing.
10. application as claimed in claim 9, so it is special in the application for the preparation of in treatment pulmonary disease medicine, for the preparation of the application in treatment respiratory tract disease medicine, for the preparation of the application in treatment upper respiratory disease medicine or for the preparation of the application in treatment cough medicine.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383397A (en) * | 2014-12-06 | 2015-03-04 | 唐云峰 | Traditional Chinese medicine composition for treating cough type asthma |
| CN111671867A (en) * | 2020-05-11 | 2020-09-18 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition for treating coronavirus pneumonia cough |
| CN115266970A (en) * | 2022-07-13 | 2022-11-01 | 柳州市中医医院(柳州市壮医医院) | Method for measuring contents of various components in exogenous cough-relieving lotion and one-measurement-multiple-evaluation detection method of exogenous cough-relieving lotion |
| CN115531392A (en) * | 2022-09-13 | 2022-12-30 | 内蒙古医科大学附属医院(内蒙古自治区心血管研究所) | Application of shionone in preparation of pneumolysin inhibitor |
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| 陈和金: "止嗽散加减治疗咳嗽80例疗效观察", 《云南中医中药杂志》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383397A (en) * | 2014-12-06 | 2015-03-04 | 唐云峰 | Traditional Chinese medicine composition for treating cough type asthma |
| CN111671867A (en) * | 2020-05-11 | 2020-09-18 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition for treating coronavirus pneumonia cough |
| CN111671867B (en) * | 2020-05-11 | 2021-09-07 | 首都医科大学附属北京中医医院 | Novel traditional Chinese medicine composition for treating mild coronary virus pneumonia cough |
| CN115266970A (en) * | 2022-07-13 | 2022-11-01 | 柳州市中医医院(柳州市壮医医院) | Method for measuring contents of various components in exogenous cough-relieving lotion and one-measurement-multiple-evaluation detection method of exogenous cough-relieving lotion |
| CN115531392A (en) * | 2022-09-13 | 2022-12-30 | 内蒙古医科大学附属医院(内蒙古自治区心血管研究所) | Application of shionone in preparation of pneumolysin inhibitor |
| CN115531392B (en) * | 2022-09-13 | 2023-07-18 | 内蒙古医科大学附属医院(内蒙古自治区心血管研究所) | Application of asterone in preparation of pneumolysin inhibitor |
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| CN103961614B (en) | 2017-12-01 |
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