CN105169064A - Medicinal preparation for whitening skin - Google Patents

Medicinal preparation for whitening skin Download PDF

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Publication number
CN105169064A
CN105169064A CN201510653884.5A CN201510653884A CN105169064A CN 105169064 A CN105169064 A CN 105169064A CN 201510653884 A CN201510653884 A CN 201510653884A CN 105169064 A CN105169064 A CN 105169064A
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China
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parts
skin whitening
pharmaceutical
rhizoma
medicinal
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CN201510653884.5A
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Chinese (zh)
Inventor
田丽华
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Zibo Qidingli Patent Information Consulting Co Ltd
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Zibo Qidingli Patent Information Consulting Co Ltd
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Priority to CN201510653884.5A priority Critical patent/CN105169064A/en
Publication of CN105169064A publication Critical patent/CN105169064A/en
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Abstract

The invention belongs to the field of traditional Chinese medicine preparations and particularly provides a medicinal preparation for whitening skin. The medicinal preparation is prepared from 20 parts of long mallotus apelta, 25 parts of pteris vittata, 20 parts of elsholtzia patrini garcke, 20 parts of gray polypody, 18 parts of mint, 20 parts of angelica sinensis, 25 parts of coptis chinensis, 25 parts of aloe, 20 parts of acanthopanax roots, 20 parts of acorus gramineus, 20 parts of rabdosia rubescens, 25 parts of lalang grass rhizome, 20 parts of polygala tenuifolia,15 parts of pollen typhae, 15 parts of cortex albiziae and 5 parts of licorice roots. The medicinal preparation can whiten the skin.

Description

A kind of pharmaceutical preparation for skin whitening
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation for skin whitening and its preparation method and application.
Background technology
Human body, in metabolic processes, defines various free radical.Wherein, the free radical of 95% is all the oxygen-derived free radicals be harmful to us.Their attack cells, produce Oxidation, and injury cell function, human activity is declined, and the aging phenomenon such as wrinkle, mottle appears in face, and skin becomes gloomy.In addition, because environmental pollution is day by day serious, can allow in skin and produce toxin, the time has been grown the colour of skin and also can become gloomy lackluster, can be played the effect of bright clothes by the use of whitening product.But current whitening product lead tolerance is comparatively large, consumer is produced whitening product and queries.For this reason, the needs that the medicine developing more skin whitening safely and effectively meets clinical treatment are bursting to.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of can the Chinese medicine preparation of skin whitening disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation for skin whitening, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: long Folium Malloti Apeltae 20 parts, Herba pteridis vittatae 25 parts, Herba Origani 20 parts, Rhizoma Polypodiodis Nipponicae 20 parts, Herba Menthae 18 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Coptidis 25 parts, Aloe 25 parts, Radix Et Caulis Acanthopanacis Senticosi 20 parts, Rhizoma Acori Graminei 20 parts, Rabdosia rubescens 20 parts, Rhizoma Imperatae 25 parts, Radix Polygalae 20 parts, Pollen Typhae 15 parts, Cortex Albiziae 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation for skin whitening, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation for skin whitening, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation skin whitening medicine for skin whitening.
Folium Malloti Apeltae is Euphorbiaceae Mallotus plant Folium Malloti Apeltae Mallotusapelta (Lour.) Muell.Arg., is used as medicine with root and leaf.Root can be adopted the whole year, cleans, and section, dries.The many using fresh herbs of leaf, or the summer, the autumn gather, dry levigation.Root, the leaf of Folium Malloti Apeltae are used as medicine.Leaf has effect of clearing away heat-damp and promoting diuresis, analgesic antidotal and hemostasis, can be used for treatment otitis media, aphtha, traumatic injury, eczema, traumatic hemorrhage etc.; The effect that root has that easing the affected liver is invigorated blood circulation, invigorating the spleen for eliminating dampness, convergence take off admittedly, can be used for the diseases such as treatment chronic hepatitis, hepatosplenomegaly, edema; Also be used for the treatment of stomachache to vomit the diseases such as water, traumatic hemorrhage and skin pruritus simultaneously.The present invention is used as medicine with leaf.
Herba pteridis vittatae, Latin is called PterisvittataL, is fern Pteridaceae Pteris plant Herba pteridis vittatae.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Suffer from abdominal pain for hygropyretic dysentery.Centipete bite is controlled in external, scabies, innominate toxic swelling.The present invention is with all herbal medicine.
Herba Origani is Labiatae Elsholtzia species Herba Origani Elsholtziaciliata (Thunb.) Hyland., with all herbal medicine.Summer, autumn tap when heading is bloomed, and remove impurity and dry or using fresh herb.Diaphoresis, expelling summer-heat, diuresis.Summer catches a cold, fever without perspiration, heatstroke, and acute gastroenteritis is uncomfortable in chest, halitosis, dysuria.
Rhizoma Polypodiodis Nipponicae is fern Polypodiaceae Polypodiodes plant Rhizoma Polypodiodis Nipponicae PolypodiumnipponicumMett., is used as medicine with root stock.Removing toxic substances is brought down a fever, expelling wind and removing dampness, cough-relieving pain relieving.For infantile hyperpyrexia, cough and asthma, acute conjunctivitis, urinary tract infection, rheumatic arthritis, toothache; Urticaria is controlled in external, furuncle toxic swelling, traumatic injury.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science thinks that primary disease is by internal injury caused by excess of seven emotions, stagnation of QI due to depression of the liver, or deficiency of kidney-QI, qi and blood stagnation, so that qi activity disturbance are qi-blood disharmony, and function is disorderly, and face loses QI and blood Rong Run, and foul smell stops and forms.In TCM Document, multiple row enters " on face miscellaneous diseases ", " dusty face ", " chloasma ", " chloasma hepaticum " and so on, the long Folium Malloti Apeltae of the present invention, Herba pteridis vittatae, Herba Origani, Rhizoma Polypodiodis Nipponicae, Herba Menthae, Radix Angelicae Sinensis, Rhizoma Coptidis, Aloe, Radix Et Caulis Acanthopanacis Senticosi heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating, invigorating the spleen and benefiting QI are monarch drug, Rhizoma Acori Graminei, Rabdosia rubescens, Rhizoma Imperatae, Radix Polygalae, Pollen Typhae, Cortex Albiziae soothing liver-QI for relieving depression, nourishing the liver and kidney are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, skin whitening successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get long Folium Malloti Apeltae 20g, Herba pteridis vittatae 25g, Herba Origani 20g, Rhizoma Polypodiodis Nipponicae 20g, Herba Menthae 18g, Radix Angelicae Sinensis 20g, Rhizoma Coptidis 25g, Aloe 25g, Radix Et Caulis Acanthopanacis Senticosi 20g, Rhizoma Acori Graminei 20g, Rabdosia rubescens 20g, Rhizoma Imperatae 25g, Radix Polygalae 20g, Pollen Typhae 15g, Cortex Albiziae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get long Folium Malloti Apeltae 20g, Herba pteridis vittatae 25g, Herba Origani 20g, Rhizoma Polypodiodis Nipponicae 20g, Herba Menthae 18g, Radix Angelicae Sinensis 20g, Rhizoma Coptidis 25g, Aloe 25g, Radix Et Caulis Acanthopanacis Senticosi 20g, Rhizoma Acori Graminei 20g, Rabdosia rubescens 20g, Rhizoma Imperatae 25g, Radix Polygalae 20g, Pollen Typhae 15g, Cortex Albiziae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get long Folium Malloti Apeltae 20g, Herba pteridis vittatae 25g, Herba Origani 20g, Rhizoma Polypodiodis Nipponicae 20g, Herba Menthae 18g, Radix Angelicae Sinensis 20g, Rhizoma Coptidis 25g, Aloe 25g, Radix Et Caulis Acanthopanacis Senticosi 20g, Rhizoma Acori Graminei 20g, Rabdosia rubescens 20g, Rhizoma Imperatae 25g, Radix Polygalae 20g, Pollen Typhae 15g, Cortex Albiziae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, pharmaceutical preparation skin whitening of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to patient cases 90 examples such as clinical observation chloasma, 18 ~ 47 years old age.The shortest person of the course of disease 2 months, most elder reaches 4 years.
4.2 diagnostic criterias:: face has chloasma in various degree, and xerosis cutis easily ftractures, senile plaque, freckle, the symptoms such as pigmentation.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule one month is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: mottle all disappears, skin smooth, seamless.Effective: mottle disappears more than 80%.Effective: mottle disappears more than 10%, and part colours is thin out.Invalid: the symptoms such as mottle are unchanged or worsen.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
Group n Recovery from illness Effective Effectively Invalid Total effective rate (%)
Treatment group 45 12 16 14 3 93.3
Blank group 45 0 1 3 41 8.9
Visible, the medicine that the present invention obtains can safe and effective skin whitening, and has no side effect.

Claims (4)

1. the pharmaceutical preparation for skin whitening, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: long Folium Malloti Apeltae 20 parts, Herba pteridis vittatae 25 parts, Herba Origani 20 parts, Rhizoma Polypodiodis Nipponicae 20 parts, Herba Menthae 18 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Coptidis 25 parts, Aloe 25 parts, Radix Et Caulis Acanthopanacis Senticosi 20 parts, Rhizoma Acori Graminei 20 parts, Rabdosia rubescens 20 parts, Rhizoma Imperatae 25 parts, Radix Polygalae 20 parts, Pollen Typhae 15 parts, Cortex Albiziae 15 parts, 5 parts, Radix Glycyrrhizae.
2. as claimed in claim 1 for the pharmaceutical preparation of skin whitening, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. as claimed in claim 1 for the pharmaceutical preparation of skin whitening, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. according to claim 1 for the application of pharmaceutical preparation in skin whitening medicine of skin whitening.
CN201510653884.5A 2015-10-11 2015-10-11 Medicinal preparation for whitening skin Withdrawn CN105169064A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105662971A (en) * 2016-03-04 2016-06-15 佛山市聚成生化技术研发有限公司 Chinese herbal medicine composition and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102366478A (en) * 2011-11-14 2012-03-07 四川逢春制药有限公司 Composition for whitening skin and resisting senescence, preparation method and application thereof
CN103083210A (en) * 2013-01-25 2013-05-08 王恩瀚 Medicine composition with skin whitening effect as well as preparation method and application thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102366478A (en) * 2011-11-14 2012-03-07 四川逢春制药有限公司 Composition for whitening skin and resisting senescence, preparation method and application thereof
CN103083210A (en) * 2013-01-25 2013-05-08 王恩瀚 Medicine composition with skin whitening effect as well as preparation method and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105662971A (en) * 2016-03-04 2016-06-15 佛山市聚成生化技术研发有限公司 Chinese herbal medicine composition and application thereof

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Application publication date: 20151223