CN105902906A - Traditional Chinese medicine composition for treating wind-cold-type cold and cough and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating wind-cold-type cold and cough and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A61K36/06—Fungi, e.g. yeasts
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention relates to a traditional Chinese medicine composition for treating wind-cold-type cold and cough and a preparation method thereof. The traditional Chinese medicine composition includes the following raw material medicines: perilla leaves, radix peucedani, divaricate saposhnikovia, notopterygium roots, platycodon grandiflorum, bitter apricot kernels, radix stemonae, ephedra salvia, radix glycyrrhizae, pericarpium citri reticulatae, ginger-processed pinellia ternata, poria cocos, stir-fried fructus aurantii and scutellaria baicalensis. The invention also relates to a preparation method of a capsule for treating the wind-cold-type cold and cough. The traditional Chinese medicine composition has the effects of relieving the exterior to dissipate cold, diffusing lung and relieving cough, is used for treating cold and cough caused by wind-cold fettering the exterior and obstruction of lung Qi with the symptoms of fever, aversion to cold, cough, nasal obstruction and running nose, headache and anhidrosis and sour-pain in limbs. The traditional Chinese medicine composition contains various medicine components and a large amount of effective target points, so that the traditional Chinese medicine composition, compared with traditional Chinese medicines in the prior art, has a wide effective range.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition treating anemofrigid cold cough and preparation method thereof, belong to technical field of Chinese medicine.
Background technology
Anemofrigid cold, cough are a kind of commonly encountered diseases, frequently-occurring diseases, serious harm human health, multiple are born in winter, spring, main
Will be by caused by diseases caused by exogenous pathogenic factor ailment said due to cold or exposure." a Plain Questions bone empty talk piece " is said: " wind enters from outward, makes us cold with shivering, and sweating is had a headache, heavy sensation of the body aversion to cold.”
" Plain Questions declares five gas pieces " is added: " five kinds of diseases caused by disorders of ZANG-QI ... disorder of the lung giving rise to cough." " interchannel six scripts cough opinion " meaning: " cold,
Summer-heat, dry, wet, wind, fiery six gas, all make us cough." characteristic of the wind being light and upward, go against one's superiors Jiao more, is positioned at the part of the body cavity above the diaphragm housing the heart and lungs at lung in the heart, main
Breathing, therefore exopathogen enters from mouth and nose or is subject to from fur, and lung is defended and stood in the breach, thus defend table discord and see aversion to cold, heating,
Headache, general pain；Impaired depurative descending of lung QI and see nasal obstruction, watery nasal discharge, cough.Treatment should abide by " it is at skin person, inducing diaphoresis ", and (" Plain Questions is cloudy
Sun should be as a big opinion piece ") justice, take dispersing wind-cold, solve and express evil principle, we's card is to set for affection of exogenous wind-cold cough,
Controlling with relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, dispersing wind-cold, be equipped with drying dampness to eliminate phlegm, the medicine of sending down the abnormal ascending QI cough-relieving, all medicines share, and play relieving exterior syndrome and dispelling cold, lung qi dispersing altogether
The merit of relieving cough and resolving phlegm.
In correlation technique, the medicine used by treatment anemofrigid cold, cough is chemical drugs and antibiotic mostly, although its curative effect is very fast,
But toxic and side effects is big, and long-term taking body is easily generated drug resistance.At the Chinese prescription of existing treatment wind and cold disease flu, general
Having the effect of relieving exterior syndrome and dispelling cold, treating anemofrigid cold when, therapeutical effect is single, to flu with the symptom such as cough do not have
Therapeutical effect or therapeutic effect are more weak, and lack harmony.
Chinese patent literature CN 104873693A (application number 201510236456.2) discloses a kind of Chinese medicine system for antitussive
Agent, preparation method and application, the raw material of the Chinese medicine preparation of described antitussive includes following composition: Folium Perillae, Radix Platycodonis, Herba Ephedrae,
Radix Peucedani, Semen Armeniacae Amarum, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, Fructus Aurantii and Radix Scutellariae, preparation method is, by described raw material each component
Folium Perillae, Radix Platycodonis, Herba Ephedrae, Radix Peucedani, Semen Armeniacae Amarum, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Coptidis, Radix Et Rhizoma Rhei and Rhizoma Atractylodis mixing, add hydrochloric acid solution leaching
Bubble, steaming and decocting, obtain medicinal residues I and filtrate I, medicinal residues I is immersed in sodium hydroxide solution, steaming and decocting, filter, obtain filtrate II；
Being pulverized by other components of described raw material, infiltration, in ethanol solution, decocts, obtains medicinal residues III；By described medicinal residues III and water
Mixing, decocts, obtains filtrate II I, above-mentioned filtrate I, filtrate II and filtrate II I is mixed, and filters, and tune pH value is 5-7,
Obtain the described Chinese medicine preparation for antitussive.
Chinese patent literature CN1364547A (application number 01100814.8) discloses a kind of nano Tongxuanlifei medicine,
It is with nanometer Folium Perillae, nanometer Radix Peucedani, nanometer Radix Platycodonis, nanometer Semen Armeniacae Amarum, nanometer Herba Ephedrae, nanometer Radix Glycyrrhizae, nanometer Pericarpium Citri Reticulatae,
Nano pinellia, nano Poria, nanometer Fructus Aurantii, nanometer Radix Scutellariae are raw material, prepare in proportion, make new pharmaceutical preparation, its
Grain fineness reaches 1200-1500 mesh, and particle diameter is 0.1-200nm, and wherein overwhelming majority particle diameter is less than 100nm, and has new thing
Property.
Although said medicine all has the medicine of dispersing wind-cold effect as monarch drug with Folium Perillae, Herba Ephedrae, but do not consider to treat wind and cold sense
Emit and carry out expelling wind and removing dampness, pain relieving simultaneously, thus have impact on therapeutic effect.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating anemofrigid cold cough and preparation method thereof, overcome existing controlling
Treat coldrex above shortcomings.
The preparation of the present invention have rapid-action, evident in efficacy, have no side effect, therapeutical effect scope wide, to flu with cough
Advantages such as coughing, have a headache, watery nasal discharge of having a stuffy nose, limb pain all can be controlled, combines, according to constitutive property, the preparation side that lot of documents is established
Method has the advantages such as efficient, energy-conservation, inexpensive, effective ingredient destruction is few.
A kind of Chinese medicine composition treating anemofrigid cold cough, raw material medicines in portions by weight composition is as follows:
Folium Perillae 20～80 parts, Radix Peucedani 20～60 parts, Radix Saposhnikoviae 20～60 parts, Rhizoma Et Radix Notopterygii 20～60 parts, Radix Platycodonis 10～60 parts,
Semen Armeniacae Amarum 10～50 parts, the Radix Stemonae 10～50 parts, Herba Ephedrae 20～60 parts, Radix Glycyrrhizae 10～60 parts, Pericarpium Citri Reticulatae 10～60 parts, Rhizoma Zingiberis Recens
The Rhizoma Pinelliae 10～50 parts, Poria 20～60 parts, Fructus Aurantii (parched) 20～60 parts, Radix Scutellariae 20～80 parts.
Preferably, raw material medicines in portions by weight composition is as follows:
Folium Perillae 30～60 parts, Radix Peucedani 20～50 parts, Radix Saposhnikoviae 20～50 parts, Rhizoma Et Radix Notopterygii 20～50 parts, Radix Platycodonis 20～50 parts,
Semen Armeniacae Amarum 20～50 parts, the Radix Stemonae 10～40 parts, Herba Ephedrae 20～50 parts, Radix Glycyrrhizae 20～50 parts, Pericarpium Citri Reticulatae 20～50 parts, Rhizoma Zingiberis Recens
The Rhizoma Pinelliae 10～40 parts, Poria 20～50 parts, Fructus Aurantii (parched) 20～50 parts, Radix Scutellariae 20～60 parts.
Further, providing a preferred embodiment here, raw material medicines in portions by weight composition is as follows:
Folium Perillae 50 parts, Radix Peucedani 30 parts, Radix Saposhnikoviae 30 parts, Rhizoma Et Radix Notopterygii 40 parts, Radix Platycodonis 30 parts, Semen Armeniacae Amarum 30 parts, the Radix Stemonae
30 parts, 40 parts of Herba Ephedrae, 30 parts of Radix Glycyrrhizae, Pericarpium Citri Reticulatae 30 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 30 parts, 30 parts of Poria, Fructus Aurantii (parched) 40 parts,
Radix Scutellariae 40 parts.
Further, providing another preferred embodiment here, raw material medicines in portions by weight composition is as follows:
Folium Perillae 40 parts, Radix Peucedani 40 parts, Radix Saposhnikoviae 40 parts, Rhizoma Et Radix Notopterygii 30 parts, Radix Platycodonis 40 parts, Semen Armeniacae Amarum 30 parts, the Radix Stemonae
20 parts, 40 parts of Herba Ephedrae, 40 parts of Radix Glycyrrhizae, Pericarpium Citri Reticulatae 30 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 20 parts, 40 parts of Poria, Fructus Aurantii (parched) 40 parts,
Radix Scutellariae 30 parts.
Further, providing the 3rd preferred embodiment here, raw material medicines in portions by weight composition is as follows:
Folium Perillae 50 parts, Radix Peucedani 30 parts, Radix Saposhnikoviae 30 parts, Rhizoma Et Radix Notopterygii 40 parts, Radix Platycodonis 30 parts, Semen Armeniacae Amarum 40 parts, the Radix Stemonae
30 parts, 30 parts of Herba Ephedrae, 30 parts of Radix Glycyrrhizae, Pericarpium Citri Reticulatae 40 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 30 parts, 30 parts of Poria, Fructus Aurantii (parched) 30 parts,
Radix Scutellariae 40 parts.
In above-mentioned each component:
Folium Perillae, for the dried leaves (or band twig) of labiate Folium Perillae Perilla frutescens (L.) Britt..Merit
Effect relieving exterior syndrome and dispelling cold, relieving QI stagnancy in the stomach.For anemofrigid cold, cough vomiting, fish Eriocheir sinensis is poisoned.
Radix Peucedani, for the dry root of samphire Peucedanum praeruptorum DUNN Peucedanum praeruptorum Dunn.Effect sending down the abnormal ascending QI
Expectorant, dissipates wind heat clearing away.Full for expectorant dyspnea of heat type, cough up phlegm yellow thick, cough due to pathogenic wind-heat's abundant expectoration.
Radix Saposhnikoviae, for the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk..
Effect expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Rhizoma Et Radix Notopterygii, for samphire Rhizoma Et Radix Notopterygii Notopterygium incisum Ting ex H.T.Chang or Radix et Rhizoma Notopterygii
The dry rhizome of Notopterygium franchetii H.de Boiss. and root.Effect relieving exterior syndrome and dispelling cold, expelling wind and removing dampness, only
Bitterly.For anemofrigid cold, stiffness of the nape of having a headache, rheumatic arthralgia, aching pain in shoulder and back.
Radix Platycodonis, for the dry root of Campanulaceae Platycodon grandiflorum (Jacq.) A.DC.Effect lung qi dispersing is dispelled
Expectorant, therapeutic method to keep the adverse QI flowing downwards sore-throat relieving, eliminating carbuncle evacuation of pus.Curing mainly cough with copious phlegm, laryngopharynx swelling and pain, aphonia, fullness in the chest and hypochondriac pain, dysentery stomachache, urine is infirmity
Close, lung abscess vomiting pus.
Semen Armeniacae Amarum, for rosaceous plant Prunus armeniaca L.var.ansu Maxim. Prunus armeniaca L.var.ansu maxim Siberia Fructus Pruni
Prunussibirica L., prunus mandshuricaKoehne Prunus mandshurica (Maxim) Koehne or Fructus Pruni Prunus armeniaca
L. dry mature seed.Effect lung qi dispersing cough-relieving, lowering the adverse-rising QI to subdue asthma, loosening bowel to relieve constipation, parasite killing detoxifies.Cure mainly cough, dyspnea with rapid and short breath breast
Full, sore throat pharyngalgia, dryness of the intestine constipation, insect poison skin infection.
The Radix Stemonae, for Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona
Japonica (Bl.) Miq or the dried root of radix stemonae tuberosae Stemona tuberosa Lour..Effect nourishing the lung to keep the adverse QI downward cough-relieving,
Parasite killing delousing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis.
Herba Ephedrae, for Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf, epheday intermedia Ephedra intermedia
Schrenket C.A.Mey. or the dry herb stem of ephedra equisetina Ephedra equisetina Bge..Effect Pulvis Diaphoreticus
Cold, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chest breath with cough, edema due to wind pathogen edema.
Radix Glycyrrhizae, for glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza
Or the dry root of Glycyrrhiza glabra L. Glycyrrhiza glabra L. and rhizome inflataBat..Effect invigorating the spleen and replenishing QI, heat clearing away
Removing toxic substances, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm,
Gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
Pericarpium Citri Reticulatae, for rutaceae orange Citrus reticulata Blanco and the dry mature skin of variety thereof.Merit
Effect regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), for the process of preparing Chinese medicine of the dry tuber of aroid Rhizoma Pinelliae Pinellia ternate (Thunb.) Breit.
Processed goods.Effect warming middle-JIAO reduces phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, for vomiting due to fluid-retention, gastral cavilty feeling of fullness.
Poria, for the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Effect promoting diuresis to eliminate damp pathogen,
Spleen invigorating, mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool has loose bowels, irritability, palpitation with fear insomnia.
Fructus Aurantii (parched), for the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof
Processed product.Effect regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.Coerce the stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion for breast, stop in phlegm retention, dirty
Device is sagging.
Radix Scutellariae, for the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Heat clearing and damp drying, rushes down
Fire removing toxic substances, hemostasis, antiabortive.Curing mainly retention of damp-heat in the interior, vomiting, dysentery, jaundice, pyretic stranguria, cough due to lung-heat coughs up phlegm, and epidemic febrile disease is generated heat
Excessive thirst, liver-fire headache conjunctival congestion, carbuncle furuncle, tell nosebleed and have blood in stool, metrostaxis, excessive fetal movement due to heat in pregnancy.
The prescription of the present invention is by Folium Perillae, Radix Peucedani, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Stemonae, Herba Ephedrae, Radix Glycyrrhizae, old
Skin, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Poria, Fructus Aurantii (parched), Radix Scutellariae form.
This prescription is that affection of exogenous wind-cold cough sets.Folium Perillae in side, Herba Ephedrae acrid in the mouth is warm in nature dissipates, with dispersing wind-cold, lung qi dispersing solution
Table, for monarch drug；Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii relieving exterior syndrome and dispelling cold, expelling wind and removing dampness, pain relieving, Radix Peucedani, Radix Platycodonis, Semen Armeniacae Amarum dispersing lung-QI and dissipating phlegm, cough-relieving
For ministerial drug；Helping with Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria drying dampness to eliminate phlegm, invigorating spleen to remove dampness with clear profit the source of producing phlegm, activating qi for lowering adverse qi is with cough-relieving；Trifoliate orange
Shell is joined Radix Platycodonis and is opened breast and the alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, with fluent mechanism of qi；The clear part of the body cavity above the diaphragm housing the heart and lungs of Radix Scutellariae hot and suffocating, i.e. lung heat clearing is hot and suffocating, the most anti-medicine pungent
Temperature heat-transformation, is also adjuvant drug；The Radix Stemonae, Radix Glycyrrhizae nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription and for making medicine.All medicines share, and play relieving exterior syndrome and dispelling cold altogether,
Effect of lung qi dispersing relieving cough and resolving phlegm.
The prescription of the present invention, effect relieving exterior syndrome and dispelling cold, lung qi dispersing antitussive.For the cold cough caused by wind and cold bundle table, inhibited pulmonary QI,
Disease sees heating, aversion to cold.Cough, watery nasal discharge of having a stuffy nose, lossless, limb pain of having a headache.The flu of modern medicine, acute and chronic gas
The cough of pipe inflammation, all with this preparation for controlling.
The application in preparation treatment anemofrigid cold cough medicine of the Chinese medicine composition of above-mentioned treatment anemofrigid cold cough.
According to currently preferred, the dosage form of above-mentioned treatment anemofrigid cold cough medicine is tablet, granule, capsule, is administered orally
Liquid or mixture.
The preparation method of a kind of capsule treating anemofrigid cold cough, comprises the steps:
(1) take Folium Perillae, Rhizoma Et Radix Notopterygii in proportion, extract volatile oil, volatile oil betacyclodextrin inclusion, prepare volatile oil bag
Knot thing, medicinal liquid and medicinal residues；
(2) take Semen Armeniacae Amarum, the Rhizoma Pinelliae and part Poria, add alcohol reflux, concentrate, prepare alcohol extraction condensed cream and alcohol extraction medicine
Slag；
(3) medicinal liquid and medicinal residues that the alcohol extraction medicinal residues and the step (1) that step (2) are prepared are prepared mix, be subsequently adding Radix Peucedani,
Radix Saposhnikoviae, Radix Platycodonis, the Radix Stemonae, Herba Ephedrae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Scutellariae, boiling, filter, filtrate is condensed into condensed cream,
Then add ethanol and make precipitation, be condensed into precipitate with ethanol condensed cream；
(4) the precipitate with ethanol condensed cream that alcohol extraction condensed cream step (2) prepared prepares with step (3) mixes, and concentrates, then
Add the residue Poria powder prepared of Poria, mixing, dry, pulverize, add volatile oil inclusion complex that step (1) prepares and auxiliary
Material, mix homogeneously, load capsule, to obtain final product.
Preferably, the preparation method of a kind of capsule treating anemofrigid cold cough, comprise the steps:
(1) take Folium Perillae, Rhizoma Et Radix Notopterygii in proportion, extract volatile oil, volatile oil betacyclodextrin inclusion, prepare volatile oil bag
Knot thing, medicinal liquid and medicinal residues；
(2) take Semen Armeniacae Amarum, the Rhizoma Pinelliae and part Poria, add the ethanol solution reflux, extract, secondary that percent by volume is 80%, every time
1-3 hour, concentrate, prepare alcohol extraction condensed cream and alcohol extraction medicinal residues；
(3) medicinal liquid and medicinal residues that the alcohol extraction medicinal residues and the step (1) that step (2) are prepared are prepared mix, be subsequently adding Radix Peucedani,
Radix Saposhnikoviae, Radix Platycodonis, the Radix Stemonae, Herba Ephedrae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Scutellariae, boiling secondary, each 1-3 hour, merge
Decocting liquid, filters, and filtrate is condensed into condensed cream, then adds ethanol and makes precipitation, takes supernatant decompression recycling ethanol, is condensed into precipitate with ethanol
Condensed cream；
(4) the precipitate with ethanol condensed cream that alcohol extraction condensed cream step (2) prepared prepares with step (3) mixes, and concentrates, then
Add Poria powder prepared by residue Poria, mixing, dry, pulverize, add volatile oil inclusion complex and shallow lake that step (1) prepares
Powder, mix homogeneously, load capsule, to obtain final product.
It is further preferred that
In described step (1), extracting in volatile oil step, Folium Perillae, Rhizoma Et Radix Notopterygii mix with the water of 8 times of quality, distillation extraction
Volatile oil, the volume mass of volatile oil and betacyclodextrin inclusion is than for 1:8, and unit is ml/g.
It is further preferred that
In described step (2), the ethanol solution that percent by volume is 80% of Semen Armeniacae Amarum, the Rhizoma Pinelliae and part Poria and 4 times of quality
Reflux, extract, secondary, each 2 hours, supernatant decompression recycling ethanol, being evaporated to relative density is 1.10～1.15,
Reference density is water, and detection temperature is 50～80 DEG C.
It is further preferred that
In described step (3), alcohol extraction medicinal residues, medicinal liquid, medicinal residues, Radix Peucedani, Radix Saposhnikoviae, Radix Platycodonis, the Radix Stemonae, Herba Ephedrae, Radix Glycyrrhizae,
The soak by water secondary of Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Scutellariae and 6 times of quality, each 2 hours, collecting decoction, filter, filtrate reduced in volume
Being 1.14～1.16 to relative density, reference density is water, and detection temperature is 55～85 DEG C, adds ethanol to ethanol volume basis
Ratio reaches 70%, stands and within 24 hours, makes precipitation, takes supernatant decompression recycling ethanol, and being concentrated into relative density is 1.20～1.25,
Reference density is water, and detection temperature is 55～85 DEG C.
It is further preferred that
In described step (4), precipitate with ethanol condensed cream mixes with alcohol extraction condensed cream, and being evaporated to relative density is 1.35～1.40,
Reference density is water, and detection temperature is 55～85 DEG C, adds Poria powder, mixing, drying under reduced pressure, pulverizes, adds volatile oil
Inclusion complex and starch, mix homogeneously, load capsule, to obtain final product.
The condition not adding restriction as extracted volatile oil etc. in above-mentioned preparation process all can use the usual operating conditions of this area.
The technical characterstic of preparation method:
Water extract-alcohol precipitation: water boiling and extraction, the yield of extract is relevant with the amount making oral solid formulation content, and yield is high,
Dose is big, and yield is low, may affect the treatment；For this water boiling and extraction, water carried-ol is heavy compares research experiment,
By water extract-alcohol precipitation, the compositions unrelated with therapeutical effect such as some polysaccharide, protein, tannin, phlegmatic temperament can be removed, can subtract
Make the volume of finished product less, keep to the greatest extent curative effect simultaneously, decrease again dose.
Meanwhile, before precipitate with ethanol, the relative density of clear paste has considerable influence to quality and the yield of manufactured goods, and clear paste relative density is little, alcohol
Heavy shallow lake is few, and product yield is high, the easy moisture absorption；Clear paste is relatively denser, and precipitate with ethanol precipitation is many, and product yield is low, and moisture absorption reduces；
By the clear paste of different relative densities, the contrast experiment of different alcohol precipitation concentrations, preferentially go out optimised process, i.e. Aqueous extracts and be concentrated into
Relative density is the clear paste of 1.14～1.16 (55-85 DEG C), adds ethanol and makes ethanol percent by volume reach 70%, stands and make for 24 hours
Precipitation, takes supernatant decompression recycling ethanol, is concentrated into the precipitate with ethanol condensed cream that relative density is 1.20～1.25 (55-85 DEG C), should
Extraction process makes end product quality stable.
Volatile oil inclusion: in the Chinese medicine preparation containing volatile oil, how to spray volatile oil, seal-packed mode joins in preparation,
This have the disadvantage that: the loss bad, volatile of the abnormal smells from the patient of manufactured goods, affect the treatment, be difficult to storage, affect product stability.
To this end, the application uses betacyclodextrin inclusion volatile oil, by using saturated water solution method to be prepared for the volatile oil of different proportion
Inclusion complex, oil properties of volatilizing before and after the quality of inclusion complex, inclusion is analyzed, and explored preparation with orthogonal design
The optimum process condition of inclusion complex, has also carried out comparative study to inclusion complex stability in capsule.Result of study shows:
Volatile oil betacyclodextrin (1:8ml:g ratio) inclusion, at a certain temperature, volatile oil adds the full of betacyclodextrin
With in aqueous solution, stirring inclusion certain time, leaching inclusion complex drying under reduced pressure, prepared inclusion complex makes volatile oil at capsule
In volatility significantly diminish, and physical property and chemical property have no change, and the stability of manufactured goods significantly improves.
The pharmacodynamics of Different Preparation is preferred: according to the physicochemical property of flavour of a drug each in prescription, in conjunction with inquiry amount of literature data,
Devise three kinds of preparation technologies, wherein technique A Folium Perillae, Rhizoma Et Radix Notopterygii, Pericarpium Citri Reticulatae distillating extracting oil；Technique B Folium Perillae, Qiang
Living and extract volatile oil, Pericarpium Citri Reticulatae and remaining medicine are with decocting；Technique C Folium Perillae, Rhizoma Et Radix Notopterygii extract volatile oil, part Poria, Semen Armeniacae Amarum, Rhizoma Zingiberis Recens
The Rhizoma Pinelliae 80% ethanol extraction, Pericarpium Citri Reticulatae and remaining medicine are with decocting；Select healthy mice, make cough model, give different process system respectively
The Capsule content obtained, number of times of coughing in observing detection and adding up the incubation period and 2 minutes that mouse cough occurs carries out sample town
Coughing effect comparative experiments, the antitussive effect of result technique C is more stable, and its cough occurs that incubation period is the longest, therefore selects technique C
Preparation technology as said preparation.
Beneficial effects of the present invention:
1, Chinese medicine composition relieving exterior syndrome and dispelling cold of the present invention, lung qi dispersing antitussive, for the flu caused by wind and cold bundle table, inhibited pulmonary QI
Cough, disease see heating, aversion to cold, cough, watery nasal discharge of having a stuffy nose, lossless, limb pain of having a headache, in said composition contain multi-medicament
Component, action target spot is numerous, and rapid-action compared with existing Chinese medicine, sphere of action is wide；Pharmacodynamics test shows: the present invention's
Chinese medicine preparation have antitussive effect, expectorant effect, antihistaminic effect of relievining asthma, suppression inflammatory exudation effect, strengthen non-specific
Immunization, In Vitro Bacteriostasis, embody medicine relieving exterior syndrome and dispelling cold, effect of lung qi dispersing antitussive；Animal is acute and long term toxicity tries
Test result to show: this product heavy dose is administered, to mice without overt toxicity effect；Long term administration, dosage reaches the near of quantity
50 times, to rat ordinary circumstance and hepatic and renal function, Main Tissues organ all without overt toxicity effect, illustrate this product be low toxicity or
Saying the nontoxic medicine of genus, safety is reliable, overcomes the shortcoming that like product toxic and side effects is big.
2, the preparation method of capsule for the treatment of anemofrigid cold of the present invention cough, take into full account each component effective ingredient,
On the basis of carrying out substantial amounts of experimental study, farthest remain effective ingredient, simultaneously sophistication, both improve
Production efficiency, shortens man-hour, reduces again energy consumption, achieves the combination of comprehensive Social benefit and economic benefit.
Detailed description of the invention
Below in conjunction with embodiment, technical scheme is described further, but institute of the present invention protection domain is not limited to this.
Embodiment 1
A kind of Chinese medicine composition treating anemofrigid cold cough, raw material medicines in portions by weight composition is as follows:
Folium Perillae 50 parts, Radix Peucedani 30 parts, Radix Saposhnikoviae 30 parts, Rhizoma Et Radix Notopterygii 40 parts, Radix Platycodonis 30 parts, Semen Armeniacae Amarum 30 parts, the Radix Stemonae
30 parts, 40 parts of Herba Ephedrae, 30 parts of Radix Glycyrrhizae, Pericarpium Citri Reticulatae 30 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 30 parts, 30 parts of Poria, Fructus Aurantii (parched) 40 parts,
Radix Scutellariae 40 parts.
The preparation method of the capsule of the Chinese medicine composition of above-mentioned treatment anemofrigid cold cough, comprises the steps:
(1) taking Folium Perillae, Rhizoma Et Radix Notopterygii in proportion, Folium Perillae, Rhizoma Et Radix Notopterygii mix with the water of 8 times of quality, distillating extracting oil,
Volatile oil betacyclodextrin inclusion, the volume mass of volatile oil and betacyclodextrin inclusion ratio is for 1:8, and unit is ml/g, system
Obtain volatile oil inclusion complex, medicinal liquid and medicinal residues；
(2) take Semen Armeniacae Amarum, the Rhizoma Pinelliae and half Poria, add the ethanol solution reflux, extract, that percent by volume is 80% of 4 times of quality
Secondary, each 2 hours, supernatant decompression recycling ethanol, being evaporated to relative density was 1.10～1.15, reference density
For water, detection temperature is 50～80 DEG C, prepares alcohol extraction condensed cream and alcohol extraction medicinal residues；
(3) medicinal liquid and medicinal residues that the alcohol extraction medicinal residues and the step (1) that step (2) are prepared are prepared mix, be subsequently adding Radix Peucedani,
Radix Saposhnikoviae, Radix Platycodonis, the Radix Stemonae, Herba Ephedrae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Scutellariae, add the soak by water secondary of 6 times of quality, each 2 little
Time, collecting decoction, filter, filtrate reduced in volume to relative density is 1.14～1.16, and reference density is water, detects temperature
It is 55～85 DEG C, then adds ethanol to ethanol percent by volume and reach 70%, stand and make precipitation in 24 hours, take supernatant and reduce pressure back
Receiving ethanol, being concentrated into relative density is 1.20～1.25, and reference density is water, and detection temperature is 55～85 DEG C, prepares precipitate with ethanol
Condensed cream；
(4) the precipitate with ethanol condensed cream that alcohol extraction condensed cream step (2) prepared prepares with step (3) mixes, and is evaporated to
Relative density is 1.35～1.40, and reference density is water, and detection temperature is 55～85 DEG C, is subsequently adding prepared by residue Poria
Poria powder, mixing, dry, pulverize, add volatile oil inclusion complex and starch that step (1) prepares, mix homogeneously, load
Capsule, to obtain final product.
Embodiment 2
A kind of Chinese medicine composition treating anemofrigid cold cough, raw material medicines in portions by weight composition is as follows:
Folium Perillae 40 parts, Radix Peucedani 40 parts, Radix Saposhnikoviae 40 parts, Rhizoma Et Radix Notopterygii 30 parts, Radix Platycodonis 40 parts, Semen Armeniacae Amarum 30 parts, the Radix Stemonae
20 parts, 40 parts of Herba Ephedrae, 40 parts of Radix Glycyrrhizae, Pericarpium Citri Reticulatae 30 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 20 parts, 40 parts of Poria, Fructus Aurantii (parched) 40 parts,
Radix Scutellariae 30 parts.
The preparation method of the oral tablet of the Chinese medicine composition of above-mentioned treatment anemofrigid cold cough, comprises the steps:
(1) taking Folium Perillae, Rhizoma Et Radix Notopterygii in proportion, Folium Perillae, Rhizoma Et Radix Notopterygii mix with the water of 6 times of quality, distillating extracting oil,
Volatile oil betacyclodextrin inclusion, the volume mass of volatile oil and betacyclodextrin inclusion is than for 1:10, and unit is ml/g,
Prepare volatile oil inclusion complex, medicinal liquid and medicinal residues；
(2) taking the Poria of Semen Armeniacae Amarum, the Rhizoma Pinelliae and 3/4ths, the ethanol solution that percent by volume is 80% adding 6 times of quality returns
Stream extracts secondary, and each 1 hour, supernatant decompression recycling ethanol, being evaporated to relative density was 1.10～1.15, ginseng
Examining density is water, and detection temperature is 50～80 DEG C, prepares alcohol extraction condensed cream and alcohol extraction medicinal residues；
(3) medicinal liquid and medicinal residues that the alcohol extraction medicinal residues and the step (1) that step (2) are prepared are prepared mix, be subsequently adding Radix Peucedani,
Radix Saposhnikoviae, Radix Platycodonis, the Radix Stemonae, Herba Ephedrae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Scutellariae, add the soak by water secondary of 8 times of quality, and each 1.5
Hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.14～1.16, and reference density is water, detection temperature
Degree is 55～85 DEG C, then adds ethanol to ethanol percent by volume and reaches 75%, stands and make precipitation in 24 hours, takes supernatant decompression
Reclaiming ethanol, being concentrated into relative density is 1.20～1.25, and reference density is water, and detection temperature is 55～85 DEG C, prepares alcohol
Heavy condensed cream；
(4) the precipitate with ethanol condensed cream that alcohol extraction condensed cream step (2) prepared prepares with step (3) mixes, and is evaporated to
Relative density is 1.35～1.40, and reference density is water, and detection temperature is 55～85 DEG C, is subsequently adding prepared by residue Poria
Poria powder, mixing, drying under reduced pressure, to pulverize, add volatile oil inclusion complex and magnesium stearate that step (1) prepares, mixing is all
Even, through normal process steps tabletting, to obtain final product.
Embodiment 3
A kind of Chinese medicine composition treating anemofrigid cold cough, raw material medicines in portions by weight composition is as follows:
Folium Perillae 50 parts, Radix Peucedani 30 parts, Radix Saposhnikoviae 30 parts, Rhizoma Et Radix Notopterygii 40 parts, Radix Platycodonis 30 parts, Semen Armeniacae Amarum 40 parts, the Radix Stemonae
30 parts, 30 parts of Herba Ephedrae, 30 parts of Radix Glycyrrhizae, Pericarpium Citri Reticulatae 40 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 30 parts, 30 parts of Poria, Fructus Aurantii (parched) 30 parts,
Radix Scutellariae 40 parts.
The preparation method of the granule of the Chinese medicine composition of above-mentioned treatment anemofrigid cold cough, comprises the steps:
(1) taking Folium Perillae, Rhizoma Et Radix Notopterygii in proportion, Folium Perillae, Rhizoma Et Radix Notopterygii mix with the water of 10 times of quality, distillating extracting oil,
Volatile oil betacyclodextrin inclusion, the volume mass of volatile oil and betacyclodextrin inclusion ratio is for 1:6, and unit is ml/g, system
Obtain volatile oil inclusion complex, medicinal liquid and medicinal residues；
(2) taking the Poria of Semen Armeniacae Amarum, the Rhizoma Pinelliae and 1/4th, the ethanol solution that percent by volume is 80% adding 4 times of quality returns
Stream extraction secondary, each 1.5 hours, supernatant decompression recycling ethanol, being evaporated to relative density is 1.10～1.15,
Reference density is water, and detection temperature is 50～80 DEG C, prepares alcohol extraction condensed cream and alcohol extraction medicinal residues；
(3) medicinal liquid and medicinal residues that the alcohol extraction medicinal residues and the step (1) that step (2) are prepared are prepared mix, be subsequently adding Radix Peucedani,
Radix Saposhnikoviae, Radix Platycodonis, the Radix Stemonae, Herba Ephedrae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Scutellariae, add the soak by water secondary of 4 times of quality, each 3 little
Time, collecting decoction, filter, filtrate reduced in volume to relative density is 1.14～1.16, and reference density is water, detects temperature
It is 55～85 DEG C, then adds ethanol to ethanol percent by volume and reach 60%, stand and make precipitation in 24 hours, take supernatant and reduce pressure back
Receiving ethanol, being concentrated into relative density is 1.20～1.25, and reference density is water, and detection temperature is 55～85 DEG C, prepares precipitate with ethanol
Condensed cream；
(4) the precipitate with ethanol condensed cream that alcohol extraction condensed cream step (2) prepared prepares with step (3) mixes, and is evaporated to
Relative density is 1.35～1.40, and reference density is water, and detection temperature is 55～85 DEG C, is subsequently adding prepared by residue Poria
Poria powder, mixing, dry, pulverize, add volatile oil inclusion complex and dextrin that step (1) prepares, mix homogeneously, pass through
Normal process steps is processed into granule, to obtain final product.
Embodiment 4
A kind of Chinese medicine composition treating anemofrigid cold cough, raw material medicines in portions by weight composition is as follows:
Folium Perillae 20 parts, Radix Peucedani 60 parts, Radix Saposhnikoviae 20 parts, Rhizoma Et Radix Notopterygii 60 parts, Radix Platycodonis 10 parts, Semen Armeniacae Amarum 50 parts, the Radix Stemonae 10
Part, 60 parts of Herba Ephedrae, 10 parts of Radix Glycyrrhizae, Pericarpium Citri Reticulatae 60 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10 parts, 60 parts of Poria, Fructus Aurantii (parched) 20 parts, Huang
A kind of reed mentioned in ancient books 80 parts.
The preparation method of capsule is with embodiment 1.
Embodiment 5
A kind of Chinese medicine composition treating anemofrigid cold cough, raw material medicines in portions by weight composition is as follows:
Folium Perillae 80 parts, Radix Peucedani 20 parts, Radix Saposhnikoviae 60 parts, Rhizoma Et Radix Notopterygii 20 parts, Radix Platycodonis 60 parts, Semen Armeniacae Amarum 10 parts, the Radix Stemonae 50
Part, 20 parts of Herba Ephedrae, 60 parts of Radix Glycyrrhizae, Pericarpium Citri Reticulatae 10 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 50 parts, 20 parts of Poria, Fructus Aurantii (parched) 60 parts, Huang
A kind of reed mentioned in ancient books 20 parts.
The preparation method of capsule is with embodiment 1.
Comparative example
A kind of Chinese medicine composition treating anemopyretic cold, is made up of the component of following weight parts: (such as Chinese patent literature
In CN1364547A shown in embodiment):
Folium Perillae 144 parts, Radix Peucedani 96 parts, Radix Platycodonis 96 parts, Semen Armeniacae Amarum 72 parts, 96 parts of Herba Ephedrae, 72 parts of Radix Glycyrrhizae, Pericarpium Citri Reticulatae
96 parts, the Rhizoma Pinelliae 72 parts, 96 parts of Poria, Fructus Aurantii 96 parts, Radix Scutellariae 96 parts.
The preparation method of the capsule of this prescription described, comprises the steps:
1, divide and take each taste Chinese crude drug, be processed into common Chinese decoction pieces according to Chinese Pharmacopoeia one；
2, divide and take each taste common Chinese decoction pieces, be processed into Nano Chinese medicine piece；
3, Nano Chinese medicine piece (powder) is prepared mixing in described ratio, according to Chinese Pharmacopoeia standard preparation through normal process steps system
Become hard capsule.
Experimental example clinical trial
One, diagnostic criteria
(1), tcm diagnosis standard is (with reference to " Chinese Internal Medicine " the i.e. whole nation unified editing five editions religion of higher medical institution TCM Major
Material is formulated)
Wind-cold affecting lung is coughed: cough low voice speaking, out of breath, and itching throat coughs white expectorant, often accompanies nasal obstruction, flows thin nasal discharge, headache, and limbs are miserable,
The exterior syndromes such as aversion to cold, generates heat, lossless, thin white fur of tongue, floating pulse or floating tight.
(2), Western medicine diagnose standard (formulating with reference to higher medical institution clinical medicine specialty " internal medicine " teaching material third edition)
Acute upper respiratory tract infection and acute tracheobronchitis:
1, onset is anxious, the most first has sneeze, watery nasal discharge of having a stuffy nose, pharyngeal discomfort, hoarseness, the symptom such as shed tears.
2, can there is heating, fear of cold, headache, general malaise.
3, cough, coughs up phlegm or without expectorant, can have the tachypnea of varying degree, feel nervous after breastbone.
4, how inconspicuous physical signs of lung is, or has respiratory murmur rougher, or has unfixed dry, moist rale.
5, white blood count and differential: how normal virus the infected is or on the low side, percentage of lymphocyte may raise；Antibacterial infects
Person's total white blood cells can raise, neutrophilic leukocytosis.
6, how without exception chest X-ray is, sometimes sees that lung marking slightly increases slightly.
Possesses 1-3 item, wherein the 3rd indispensability.
(3), state of an illness criterion (" instruct former to defend medicine word the 10th with reference to Ministry of Public Health file [88] by antitussive and antiasthmatic medicine clinical research
Then " formulate)
1, cough:
Slight cough (+): it is interrupted cough, does not affect orthobiosis and work；
Mild cough's (++): between slight and severe are coughed；
Mild cough's (+++): cough round the clock frequently or apasm of coughing, affect work and sleep.
2, amount of expectoration:
Amount of expectoration few (+): expectoration 10-50 milliliter round the clock；
In amount of expectoration (++): expectoration 51-100 milliliter round the clock；
Amount of expectoration many (+++): expectoration round the clock more than 100 milliliters.
3, pant:
Slightly pant (+): pant and occasionally have outbreak, mild degree, do not affect sleep or movable；
Moderate is panted (++): between slight and severe are panted；
Severe is panted (+++): pant substantially, it is impossible to flat sleeping, and impact is slept and movable.
Among three, weigh most the degree of, be this conditions of patients degree.
Two, test case standard:
1, case standard is included in:
All meeting above-mentioned Chinese and western medicine diagnostic criteria, morbidity, less than 2 days persons, all can include range of observation in.
2, Excluded cases standard:
(1) suppurative tonsillitis, bronchiectasis, chronic bronchitis concurrent infection, emphysema, pneumonia, pulmonary tuberculosis,
Fungal infection, the patient such as respiratory system irritative gas allergy；
(2) with the diseases such as cardiovascular, Liver and kidney and hemopoietic system severe primary, psychotic.
(3) gestation or women breast-feeding their children, those who are allergic to this drug.
(4) once disappearance person was started by antibiotic, antipyretic, sign before treatment.
(5) all inclusive criteria is not met, not by regulation medication, it is impossible to judge curative effect or data is congruent affects the treatment or safety
Property judgement person.
Three, Therapeutic Method:
1, use random table packet, set up treatment group and matched group；
2, medication:
(1) treatment group: patient is administered orally the capsule of embodiment 1, each 2 of dose, three times a day, it serve on 7 days；
(2) matched group: the capsule of patient's oral contrast example, each 2 of dose, three times a day, it serve on 7 days；
(3) two groups of patients, during Ureteral Calculus, must not add with the Chinese and western drugs of other treatment primary disease.
Four, observation index:
1, symptom and sign: cough, cough up phlegm, pant, generate heat (T DEG C), aversion to cold, nasal obstruction, rhinorrhea with clear discharge, headache, limbs
Miserable, tongue fur, pulse condition, auscultation of lung.
2, lab testing:
(1) total white blood cells and classification；
(2) routine urinalysis；
(3) hepatic and renal function.
Five, curative effect determinate standard (" instruct former to defend medicine word the 10th with reference to Ministry of Public Health file [88] by the research of antitussive and antiasthmatic clinical drug
Then " formulate)
Outcome measure divides clinical recovery, level Four effective, effective, invalid.
(1) cough, expectorant, breathe heavily individual event curative effect
1, clinical recovery: treat transference cure in latter 7 days；
2, effective: in treating latter 7 days, score value declines >=2/3；
3, effective: in treating latter 7 days, score value declines ＜ 2/3, and >=1/3；
4, invalid: in treating latter 7 days, score value declines ＜ 1/3.
(2) comprehensive therapeutic effect
1, clinical recovery: cough after treatment, expectorant, breathe heavily, generate heat, the symptom such as aversion to cold, nasal obstruction, watery nasal discharge, headache, limbs are miserable
Disappear；
2, effective: in treating latter 7 days, above-mentioned symptom integrated value declines >=2/3；
3, effective: in treating latter 7 days, above-mentioned symptom integrated value declines ＜ 2/3, and >=1/3；
4, invalid: in treating latter 7 days, above-mentioned symptom integrated value declines ＜ 1/3.
Six, clinical trial:
1. treatment group: the Chinese medicinal composition preparation treatment anemofrigid cold cough of the application embodiment of the present invention 1, oral test medicine, controls
The treatment cycle is 7 days.Treat in 236 example anemofrigid cold cough patients altogether, male patient 124 example, female patient 112 example,
Age is between 12 years old～65 years old.Fully recover 92 examples, cure rate 39%；Effective 57 examples, obvious effective rate 24%；Effective 68 examples,
Effective percentage 29%；Invalid 19 examples, inefficiency 8%.Total effective rate is 92%.
2. matched group: apply the Chinese medicinal composition preparation treatment anemofrigid cold cough of comparative example of the present invention, oral comparison medicine, treatment
Cycle is 7 days.Treat in 138 example anemofrigid cold cough patients altogether, male patient 76 example, female patient 62 example, the age
Between 12 years old～65 years old.Fully recover 48 examples, cure rate 35%；Effective 30 examples, obvious effective rate 22%；Effective 43 examples, effectively
Rate 31%；Invalid 17 examples, inefficiency 12%.Total effective rate is 88%.
Statistical result shows: treatment group and matched group significant difference.Clinical trial shows: Chinese medicine composition of the present invention is a kind of
Having relieving exterior syndrome and dispelling cold, the Chinese medicine preparation of lung qi dispersing antitussive, this medicine reasonable compatibility, complementation is collaborative, and dialectical treatment can be used for wind and cold
Bundle cold cough caused by table, inhibited pulmonary QI, disease see heating, aversion to cold, cough, watery nasal discharge of having a stuffy nose, headache, lossless, limbs
Pains etc., effect is notable.
It should be noted that above-mentioned specific embodiment is exemplary, under the above-mentioned teaching of the present invention, those skilled in the art
Various improvement and deformation can be carried out on the basis of above-described embodiment, and these improve or deformation falls at the protection model of the present invention
In enclosing.
It will be understood by those skilled in the art that specific descriptions above are intended merely to explain the purpose of the present invention, be not intended to limit
The present invention.Protection scope of the present invention is limited by claim and equivalent thereof.
Claims (10)
1. treating a Chinese medicine composition for anemofrigid cold cough, raw material medicines in portions by weight composition is as follows:
Folium Perillae 20～80 parts, Radix Peucedani 20～60 parts, Radix Saposhnikoviae 20～60 parts, Rhizoma Et Radix Notopterygii 20～60 parts, Radix Platycodonis 10～60 parts,
Semen Armeniacae Amarum 10～50 parts, the Radix Stemonae 10～50 parts, Herba Ephedrae 20～60 parts, Radix Glycyrrhizae 10～60 parts, Pericarpium Citri Reticulatae 10～60 parts, Rhizoma Zingiberis Recens
The Rhizoma Pinelliae 10～50 parts, Poria 20～60 parts, Fructus Aurantii (parched) 20～60 parts, Radix Scutellariae 20～80 parts.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that raw material medicines in portions by weight composition is as follows:
Folium Perillae 30～60 parts, Radix Peucedani 20～50 parts, Radix Saposhnikoviae 20～50 parts, Rhizoma Et Radix Notopterygii 20～50 parts, Radix Platycodonis 20～50 parts,
Semen Armeniacae Amarum 20～50 parts, the Radix Stemonae 10～40 parts, Herba Ephedrae 20～50 parts, Radix Glycyrrhizae 20～50 parts, Pericarpium Citri Reticulatae 20～50 parts, Rhizoma Zingiberis Recens
The Rhizoma Pinelliae 10～40 parts, Poria 20～50 parts, Fructus Aurantii (parched) 20～50 parts, Radix Scutellariae 20～60 parts.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterised in that raw material medicines in portions by weight composition is as follows:
Folium Perillae 50 parts, Radix Peucedani 30 parts, Radix Saposhnikoviae 30 parts, Rhizoma Et Radix Notopterygii 40 parts, Radix Platycodonis 30 parts, Semen Armeniacae Amarum 30 parts, the Radix Stemonae
30 parts, 40 parts of Herba Ephedrae, 30 parts of Radix Glycyrrhizae, Pericarpium Citri Reticulatae 30 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 30 parts, 30 parts of Poria, Fructus Aurantii (parched) 40 parts,
Radix Scutellariae 40 parts；
Preferably, raw material medicines in portions by weight composition is as follows:
Folium Perillae 40 parts, Radix Peucedani 40 parts, Radix Saposhnikoviae 40 parts, Rhizoma Et Radix Notopterygii 30 parts, Radix Platycodonis 40 parts, Semen Armeniacae Amarum 30 parts, the Radix Stemonae
20 parts, 40 parts of Herba Ephedrae, 40 parts of Radix Glycyrrhizae, Pericarpium Citri Reticulatae 30 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 20 parts, 40 parts of Poria, Fructus Aurantii (parched) 40 parts,
Radix Scutellariae 30 parts；
Preferably, raw material medicines in portions by weight composition is as follows:
Folium Perillae 50 parts, Radix Peucedani 30 parts, Radix Saposhnikoviae 30 parts, Rhizoma Et Radix Notopterygii 40 parts, Radix Platycodonis 30 parts, Semen Armeniacae Amarum 40 parts, the Radix Stemonae
30 parts, 30 parts of Herba Ephedrae, 30 parts of Radix Glycyrrhizae, Pericarpium Citri Reticulatae 40 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 30 parts, 30 parts of Poria, Fructus Aurantii (parched) 30 parts,
Radix Scutellariae 40 parts.
4. the Chinese medicine composition treating anemofrigid cold cough described in claim 1-4 any one is coughed at preparation treatment anemofrigid cold
Cough the application in medicine.
Apply the most as claimed in claim 4, it is characterised in that described treatment anemofrigid cold cough medicine dosage form be tablet,
Granule, capsule, oral liquid or mixture.
6. the preparation method of the capsule treating anemofrigid cold cough, it is characterised in that comprise the steps:
(1) take Folium Perillae, Rhizoma Et Radix Notopterygii in proportion, extract volatile oil, volatile oil betacyclodextrin inclusion, prepare volatile oil bag
Knot thing, medicinal liquid and medicinal residues；
(2) take Semen Armeniacae Amarum, the Rhizoma Pinelliae and part Poria, add alcohol reflux, concentrate, prepare alcohol extraction condensed cream and alcohol extraction medicine
Slag；
(3) medicinal liquid and medicinal residues that the alcohol extraction medicinal residues and the step (1) that step (2) are prepared are prepared mix, be subsequently adding Radix Peucedani,
Radix Saposhnikoviae, Radix Platycodonis, the Radix Stemonae, Herba Ephedrae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Scutellariae, boiling, filter, filtrate is condensed into condensed cream,
Then add ethanol and make precipitation, be condensed into precipitate with ethanol condensed cream；
(4) the precipitate with ethanol condensed cream that alcohol extraction condensed cream step (2) prepared prepares with step (3) mixes, and concentrates, then
Add the residue Poria powder prepared of Poria, mixing, dry, pulverize, add volatile oil inclusion complex that step (1) prepares and auxiliary
Material, mix homogeneously, load capsule, to obtain final product.
7. preparation method as claimed in claim 6, it is characterised in that comprise the steps:
(1) take Folium Perillae, Rhizoma Et Radix Notopterygii in proportion, extract volatile oil, volatile oil betacyclodextrin inclusion, prepare volatile oil bag
Knot thing, medicinal liquid and medicinal residues；
(2) take Semen Armeniacae Amarum, the Rhizoma Pinelliae and part Poria, add the ethanol solution reflux, extract, secondary that percent by volume is 80%, every time
1-3 hour, concentrate, prepare alcohol extraction condensed cream and alcohol extraction medicinal residues；
(3) medicinal liquid and medicinal residues that the alcohol extraction medicinal residues and the step (1) that step (2) are prepared are prepared mix, be subsequently adding Radix Peucedani,
Radix Saposhnikoviae, Radix Platycodonis, the Radix Stemonae, Herba Ephedrae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Scutellariae, boiling secondary, each 1-3 hour, merge
Decocting liquid, filters, and filtrate is condensed into condensed cream, then adds ethanol and makes precipitation, takes supernatant decompression recycling ethanol, is condensed into precipitate with ethanol
Condensed cream；
(4) the precipitate with ethanol condensed cream that alcohol extraction condensed cream step (2) prepared prepares with step (3) mixes, and concentrates, then
Add Poria powder prepared by residue Poria, mixing, dry, pulverize, add volatile oil inclusion complex and shallow lake that step (1) prepares
Powder, mix homogeneously, load capsule, to obtain final product.
Preparation method the most as claimed in claims 6 or 7, it is characterised in that in described step (1), extracts volatile oil step
In Zhou, Folium Perillae, Rhizoma Et Radix Notopterygii mix with the water of 8 times of quality, distillating extracting oil, volatile oil and the body of betacyclodextrin inclusion
Long-pending mass ratio is 1: 8, and unit is ml/g；
Preferably, in described step (2), the percent by volume of Semen Armeniacae Amarum, the Rhizoma Pinelliae and part Poria and 4 times of quality is 80%
Ethanol solution reflux, extract, secondary, each 2 hours, supernatant decompression recycling ethanol, be evaporated to relative density be 1.10～
1.15, reference density is water, and detection temperature is 50～80 DEG C.
Preparation method the most as claimed in claims 6 or 7, it is characterised in that in described step (3), alcohol extraction medicinal residues, medicine
Liquid, medicinal residues, Radix Peucedani, Radix Saposhnikoviae, Radix Platycodonis, the Radix Stemonae, Herba Ephedrae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Scutellariae and the soak by water of 6 times of quality
Secondary, each 2 hours, collecting decoction, filter, filtrate reduced in volume to relative density is 1.14～1.16, reference density
For water, detection temperature is 55～85 DEG C, adds ethanol to ethanol percent by volume and reaches 70%, stands and make precipitation in 24 hours, take
Clear liquid decompression recycling ethanol, being concentrated into relative density is 1.20～1.25, and reference density is water, and detection temperature is 55～85 DEG C.
Preparation method the most as claimed in claims 6 or 7, it is characterised in that in described step (4), precipitate with ethanol condensed cream
Mixing with alcohol extraction condensed cream, being evaporated to relative density is 1.35～1.40, and reference density is water, detection temperature be 55～
85 DEG C, add Poria powder, mixing, drying under reduced pressure, pulverize, add volatile oil inclusion complex and starch, mix homogeneously, load glue
Capsule, to obtain final product.
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| CN107375776A (en) * | 2017-06-27 | 2017-11-24 | 成都恒凌科技有限公司 | A kind of cough suppressing medicine composition |
| CN107823290A (en) * | 2017-12-01 | 2018-03-23 | 上海中医药大学 | A kind of Chinese medicine composition, extract and its application for treating cough after common cold |
| CN108743858A (en) * | 2018-09-13 | 2018-11-06 | 代小波 | A kind of Chinese medicine composition and preparation method thereof for treating cough |
| CN109289018A (en) * | 2018-11-07 | 2019-02-01 | 云南望子隆药业有限公司 | A kind of fiber crops osmanthus common cold pill and its preparation process and detection method and purposes |
| CN111297996A (en) * | 2020-04-09 | 2020-06-19 | 国华鹏源股份有限公司 | Novel tablet for treating common cold due to wind-cold |
| CN115089690A (en) * | 2022-08-03 | 2022-09-23 | 珠海横琴亘德生物科技有限公司 | Chinese herbal medicine medicated bath formula for nursing cold and cough |
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| CN116077594A (en) * | 2023-01-09 | 2023-05-09 | 陕西省中医药研究院 | Traditional Chinese medicine for treating respiratory tract virus infection |
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| CN107375776A (en) * | 2017-06-27 | 2017-11-24 | 成都恒凌科技有限公司 | A kind of cough suppressing medicine composition |
| CN107823290A (en) * | 2017-12-01 | 2018-03-23 | 上海中医药大学 | A kind of Chinese medicine composition, extract and its application for treating cough after common cold |
| CN107823290B (en) * | 2017-12-01 | 2021-03-09 | 上海中医药大学 | Traditional Chinese medicine composition for treating cough after cold, extract and application thereof |
| CN108743858A (en) * | 2018-09-13 | 2018-11-06 | 代小波 | A kind of Chinese medicine composition and preparation method thereof for treating cough |
| CN109289018A (en) * | 2018-11-07 | 2019-02-01 | 云南望子隆药业有限公司 | A kind of fiber crops osmanthus common cold pill and its preparation process and detection method and purposes |
| CN111297996A (en) * | 2020-04-09 | 2020-06-19 | 国华鹏源股份有限公司 | Novel tablet for treating common cold due to wind-cold |
| CN115969942A (en) * | 2022-02-07 | 2023-04-18 | 河南合智医药科技有限公司 | Cataplasm acupoint plaster for treating infantile wind-cold cough and preparation method thereof |
| CN115089690A (en) * | 2022-08-03 | 2022-09-23 | 珠海横琴亘德生物科技有限公司 | Chinese herbal medicine medicated bath formula for nursing cold and cough |
| CN116077594A (en) * | 2023-01-09 | 2023-05-09 | 陕西省中医药研究院 | Traditional Chinese medicine for treating respiratory tract virus infection |
| CN116077594B (en) * | 2023-01-09 | 2023-11-03 | 陕西省中医药研究院 | Traditional Chinese medicine for treating respiratory tract virus infection |
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Application publication date: 20160831 |