CN105055950A - Chinese herbal preparation for treating recurrent oral ulceration and preparation method of Chinese herbal preparation - Google Patents

Abstract

The invention discloses a Chinese herbal preparation for treating recurrent oral ulceration. The Chinese herbal preparation is prepared from the following herbs by a certain weight ratio: pinellia ternata, coptis chinensis, radix ophiopogonis, rheum officinale, pseudobulb of appendiculate cremastra, radix scutellariae, radix achyranthis bidentatae, herba verbenae, gypsum, rhizoma anemarrhenae, fructus gardeniae, herba taraxaci, dahurian patrinia herb, manyleaf paris rhizome, cortex moutan radicis, radix paeoniae alba, rhizoma polygoni cuspidati, common lophatherum herb, radix geutianae, plantain herb, cortex cinnamomi, radix rehmanniae praeparata, medulla tetrapanacis and radix glycyrrhizae. The Chinese herbal preparation has the effects of eliminating dampness and heat, promoting tissue regeneration and wound healing, clearing away heart-fire to relieve restlessness, reinforcing spleen and excreting dampness, and therefore, can effectively treat recurrent oral ulceration.

Description

A kind of Chinese medicine preparation for the treatment of recurrent oral ulceration and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of recurrent oral ulceration, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Recurrent oral ulceration is ulcerative lesions disease common in the disease of cari oris mucosa, and sharp ache during outbreak, causalgia unbearably.Chinese medicine thinks that primary disease is because feelings will is unsuccessful, ferritic is weak, the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens causes liver to be lost, and bar reaches, dysfunction of the spleen in transportation, stagnation of QI due to depression of the liver, hot and suffocating fire-transformation, hyperactivity of deficient fire are fumigated ill in mouth, long-term recurrent exerbation will directly affect the immunologic function of the whole body of patient, cause metabolism disorder, there is the General Symptoms such as halitosis, chronic pharyngitis, constipation, headache, dizziness, nauseating, weak, energy is not concentrated, insomnia, agitation, heating, lymphadenectasis, have a strong impact on the work of patient, life, even cause and cancerate or canceration.

Oral ulcer clinically with oral mucosa recurrent exerbation one or several isolated circle or oval shallow table ulcer for feature, normal companion burns sample pain, especially chewing, speak and contact acid, the irritable food such as peppery time pain more obvious.Concerning patient, though oral ulcer is without fatal risk, gives their work, life brings great misery, particularly to some often repeatedly or cureless patient, not only draw worries in spirit, return patient and bring endless misery.

Current doctor trained in Western medicine to the cause of disease of this disease and mechanism of causing a disease still indefinite, and the performance of everyone pathogenic process, occurring degree, disease damage has difference more, individual variation is large, and medical treatment, mainly based on topical therapeutic, is substantially all symptomatic treatment, and these Therapeutic Method are mainly for the purpose of easing the pain,, effect is not very desirable, and therapeutic process is long, easy recurrence, brings great misery to patient.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of recurrent oral ulceration, this Chinese medicine preparation has good effect for recurrent oral ulceration, and the time is short, not easily recurs, cheap feature.Make patient break away from slight illness early, recover orthobiosis.

Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this alleviation duchenne muscular dystrophy.

Inventor is in clinical treatment practice for many years, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of recurrent oral ulceration repeatedly, the present invention selects the Rhizoma Pinelliae, Rhizoma Coptidis, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Pseudobulbus Cremastrae Seu Pleiones, Radix Scutellariae, Radix Achyranthis Bidentatae, Herba Verbenae, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Fructus Gardeniae, Herba Taraxaci, Herba Patriniae, Rhizoma Paridis, Cortex Moutan, the Radix Paeoniae Alba, Rhizoma Polygoni Cuspidati, Herba Lophatheri, Radix Gentianae, Herba Plantaginis, Cortex Cinnamomi, Radix Rehmanniae Preparata, Medulla Tetrapanacis, Radix Glycyrrhizae combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is eliminating damp-heat, promoting tissue regeneration and ulcer healing, clear away heart-fire relieving restlessness, effect of spleen invigorating eliminating dampness by diuresis, thus effectively can treat recurrent oral ulceration.

The effect of Chinese medicine of the present invention:

Wherein:

The Rhizoma Pinelliae: be the tuber at the Rhizoma Arisaematis section plant Rhizoma Pinelliae (Pinelliaternata (Thunb.) Breit.).Nature and flavor: pungent, temperature, poisonous.Enter spleen, stomach warp.Effect: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.The pungent loose warm-dryness syndrome of these product is poisonous, main enter taste double enter lung, water of manageing it wets, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.Water is wet to be gone, and the strong and sputum of spleen is from disappearing, and inverse gas falls then harmonization of the stomach and feeling of fullness vomiting from only, therefore is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.Both cure mainly the abundant expectoration cough with asthma QI rising in reverse order of spleen damp-phlegm heap soil or fertilizer over and around the roots, control again the dizzy palpitation and insomnia that damp-phlegm is violated." property of medicine opinion ": expectorant saliva, appetite promoting and the spleen strengthening, anti-nausea, go expectorant in the heart full, lower lung qi, master coughs knot.New survivor rub be coated with carbuncle do not disappear, can tumor wart be removed.

Rhizoma Coptidis: be the dry rhizome of ranunculaceae plant Rhizoma Coptidis CoptischinensisFranch., Coptis deltoidea C.Y.Cheng et Hsiao CoptisdeltoideaC.Y.ChengetHsiao or Coptis Teeta Wall CoptisteetaWall..Nature and flavor: bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.This product heat clearing and damp drying, eliminating fire and detoxication, often joins the treatment such as Radix Scutellariae, Fructus Gardeniae aphtha of the mouth and tongue, carbuncle furunculosis etc.Antibacterial action: staphylococcus aureus, Hemolytic streptococcus, streptococcus pneumoniae, meningococcus, dysentery bacterium, anthrax bacillus etc.Detoxication: antagonism bacteriotoxin, reduction staphylococcus aureus coagulase, hemolysin are tired, and reduce colibacillary virulence.Suppress kinds of experiments inflammation, effective ingredient is berberine, and Anti-inflammatory Mechanism discharges relevant with stimulation corticotropin.

Radix Ophiopogonis: be the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogonjaponicus (Thunb.) Ker-Gawl..Nature and flavor: sweet, micro-hardship, to be slightly cold.GUIXIN, lung, stomach warp.Effect: reinforcing stomach reg fluid, nourishing lung-YIN, clear away heart-fire relieving restlessness.Radix Ophiopogonis can clear away heart-fire in yin nourishing, and relieving restlessness is calmed the nerves.The heart-nutriment, fever aggravated at night is entered with controlling warm febrile disease.Normal and Herba Dendrobii matches.

Radix Et Rhizoma Rhei: be polygonum rheum palmatum RheumpalmatumL., Rheum tanguticum RheumtanguticumMaximexBalf.Or Rheum officinale RheumofficinaleBaill.Dry root and rhizome.Nature and flavor: bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Effect: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.This product bitter cold, has the effect of stronger relieving constipation by purgation, and has the effect of good blood circulation promoting and blood stasis dispelling, and the discharge function Main Function position of Radix Et Rhizoma Rhei, at large intestine, can increase enterokinesia, suppresses enteral moisture absorption, promotes defecation; Radix Et Rhizoma Rhei has anti-infectious function, all has inhibitory action to multiple Gram-positive and negative bacterium, due to wherein containing tannin, has the effect of stomach invigorating and function of gallbladder promoting.

Pseudobulbus Cremastrae Seu Pleiones: be the dry pseudobulb of orchid Cremastra appendiculata Cremastraappendiculata (D.Don) Makino, pleione bulbocodioides Pleionebulbocodioides (Franch.) Roife or Pleione yunnanensis PleioneyunnanensisRoife.Nature and flavor: sweet, pungent, cold, mild toxicity.Return liver, stomach, lung meridian.Effect: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.This product has the merit of detoxicating and resolving stagnation of pathogens detumescence, in recent years this product Guang general ground Yu mass in the abdomen mass in the abdomen and kinds of tumors.Normal and Bulbus Fritillariae Thunbergii, Spica Prunellae are used together.

Radix Scutellariae: be the dry root of labiate Radix Scutellariae ScutellariabaicalensisGeorgi.Nature and flavor: bitter, cold.Return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.The clinical practice of Radix Scutellariae is antibacterial relatively good, and does not develop immunity to drugs.This product has the merit of clearing away heat and cooling blood hemostasis, intimately flourishing with controlling, the haematemesis of the absurd row of forcing blood, and metrorrhagia, has blood in stool, and normal being equal to Radix Rehmanniae, Rhizoma Imperatae is used.

Radix Achyranthis Bidentatae: be the root of Amaranthus mangostanus L. section herbaceos perennial Radix Achyranthis Bidentatae or RADIX CYATHULAE.Nature and flavor: bitter, sour, flat.Return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, conducting blood to flow downwards, invigorating the liver and kidney, bone and muscle strengthening.

Herba Verbenae: be the dry aerial parts of Verbenaceae Herba Verbenae VerbenaofficinalisL..Nature and flavor: bitter, cool.Return liver, spleen channel.Effect: promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema.For lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria." Bencao Jingshu ": Herba Verbenae is originally the medicine of removing heat from blood removing blood stasis.Bottom skin ulcer person, the pole of heat in blood, furthermore damp and hot, therefore blood stains are turbid forms skin ulcer, and have worm also.The cool pyrolysis of blood, the broken and row of dirty person, waste and be not recovered.CHEN Zang-Qi calls its removing blood stasis parasite killing, also this meaning ear.

Gypsum Fibrosum: be Sulfates mineral anhydrite race Gypsum Fibrosum, main containing hydrous calcium sulfate (CaSO42H2O).Nature and flavor: sweet, pungent, Great Cold.Attach to the lung and stomach meridians.Effect: clearing away heat-fire, relieving restlessness is quenched the thirst.For fever caused by exogenous pathogenic factors, high hot excessive thirst, dyspnea and cough due to lung-heat, the high Sheng of stomach-fire, headache, toothache.Gypsum Fibrosum is the key medicine of removing summer-heat edema caused by disorder of QI excess-heat, and all heat is shown in that at edema caused by disorder of QI high fever sweating, excessive thirst, arteries and veins carry out loud person, all can with cold and cool Gypsum Fibrosum with clearing away heat-fire.As use same with heat removing and blood cooling medicine, Shang Nengyong controls the disease that intenseness of heat sends out the intense heat in both QI and YING systems such as speckle, unconsciousness and delirium.Gypsum Fibrosum is apt to lung heat clearing gastric heat, boiling or the disease such as excessiveness of stomach-fire, all can use this product as seen that pathogenic heat are strongly fragrant.When clinical practice as being equipped with the Rhizoma Anemarrhenae, then clearing away heat-fire, can Zhi Yangming interior-heat; As joined Herba Ephedrae, then clearing away and dispersing lung-heat, to dyspnea and cough due to lung-heat; Control stomach-fire toothache, join Radix Rehmanniae Preparata, then stomach nourishing and vital essence replenishing, control toothache caused by fire of deficiency type; Join Radix Ginseng, then heat clearing away QI invigorating, control intenseness of heat consumption of both body fluid and QI.

The Rhizoma Anemarrhenae: be the dry rhizome of liliaceous plant Rhizoma Anemarrhenae AnemarrhenaasphodeloidesBunge..Nature and flavor: bitter, sweet, cold.Return lung, stomach, kidney channel.Effect: clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.The disease of the lung sthenia gastropyrexias such as, full and large pulse fidgety, thirsty for epidemic febrile disease, high heat and dyspnea and cough due to lung-heat, expectorant are yellow and thick.Rhizoma Anemarrhenae bitter cold, upper energy clearing away lung-heat, middle energy clearing stomach fire, therefore be applicable to the disease that lung stomach has excess-heat.Normal and the same use of Gypsum Fibrosum of this product, can strengthen the clearing away heat-fire effect of Gypsum Fibrosum.

Fructus Gardeniae: be the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae GardeniajasminoidesEllis.Nature and flavor: bitter, cold.GUIXIN, lung, tri-jiao channel.Effect: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.For calentura heating, vexed not rather wait disease.Fructus Gardeniae is kind can expel the heat-evil and relieving restlessness in pathogenic fire purging.At the edema caused by disorder of QI disease initial stage of fever caused by exogenous pathogenic factors, see have heating, the disease such as uncomfortable in chest, vexed, available Fructus Gardeniae coordinates Semen Sojae Preparatum, expels the heat-evil, relieving restlessness resolving depression with expelling pathogenic factors from the exterior.See the diseases such as high heat is fidgety, unconsciousness and delirium as belonged to all excess-heat fire diseases, available this product joins the pathogenic fire purgings such as Rhizoma Coptidis and clear pathogen is warm.The haematemesis caused for pyretic toxicity, excess-fire, epistaxis, hematuria, the disease such as conjunctival congestion and swelling pain and sore swollen toxin.

Herba Taraxaci: Herba Taraxaci, also known as bed-wetting grass, is feverfew Herba Taraxaci ToraxacummongolicumHand.Mazz., alkali ground Herba Taraxaci ToraxacumborealisinenseKitam. or the dry herb belonging to several plants together.Nature and flavor: sweet, micro-hardship, cold.Return liver, stomach warp.Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Herba Taraxaci has effect of antiinflammatory, antibacterial, antitumor, heat-clearing and toxic substances removing, and applied range on modern clinic, makes good use of.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Acute mastitis caused by pyretic toxicity is swollen and ache, furuncle has good effect, juice can be decocted separately and take orally, or external application local; Also other heat and toxic materials clearing away medicine can be coordinated with using.

Herba Patriniae: be Herba Patriniae section plant Hemerocallis citrina Baroni dragon bud PatriniascabiosaefoliaFisch.exLink., patrima villosa (bitter vegetarian) P.villosa (Thunb.) Juss., with root stock and root, all herbal medicine.Nature and flavor: pungent, bitter, cool.Return stomach, large intestine, Liver Channel.Effect: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.The compatibility such as normal and Caulis Sargentodoxae, Semen Coicis, Semen Persicae, Cortex Moutan, Radix Et Rhizoma Rhei clinically, with controlling acute appendicitis; With compatibilities such as Herba Houttuyniae, Radix Platycodonis, Semen Coicis, Semen Benincasae, Rhizoma Phragmitiss, with controlling lung abscess (lung abscess); With the compatibility such as Flos Lonicerae, Fructus Forsythiae, with controlling sore and toxic, mash external application with the fresh grass of this product simultaneously.Join the medicine such as Flos Carthami, Fructus Crataegi, control postnatal blood stasis, the disease such as twinge in abdomen.

Rhizoma Paridis: be the rhizome of liliaceous plant Rhizoma Paridis, RHIZOMA PARIDIS and several congeners thereof.Nature and flavor: bitter, acrid, cold, poisonous.Enter the heart, Liver Channel.Effect: heat-clearing and toxic substances removing; Reducing swelling and alleviating pain; Cool liver arresting convulsion.Main carbuncle sore tumefacting virus; Pharyngeal swelling sore throat; Acute mastitis; Snake bite and insect sting; Traumatic pain; Liver-heat is twitched.Modern medicine study, Rhizoma Paridis may be used for treatment surgery inflammation.

Cortex Moutan: be the dry root bark of ranunculaceae peony PaeoniasuffruticosaAndr..Nature and flavor: bitter, cool.GUIXIN, liver, kidney, lung meridian.Effect: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.This product cold nature, can clearing heat in YING system divide, blood system excess-heat, have the merit of cooling blood for hemostasis, and Cortex Moutan is pungent cold, is apt to into blood system, can removing heat from blood with hemostasis, can invigorate blood circulation with dissipating blood stasis again, the kind logical heat in blood stasis of blood is stagnant, normal with Radix Rehmanniae, Radix Paeoniae Rubra is same uses.For the disease such as sore and toxic, acute appendicitis, this product is also conventional medicine.Treating carbuncle sore can coordinate heat and toxic materials clearing away medicine as Fructus Forsythiae, Herba Violae and so on; Controlling acute appendicitis can use equivalent with Radix Et Rhizoma Rhei from the beginning of failing pus person.This product with eliminating carbuncle, can be used for acute appendicitis and carbuncle sore tumefacting virus by clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, and the acute appendicitis initial stage can compatibility Radix Et Rhizoma Rhei, also can join the resolving heat and reducing pathogenic fire such as Flos Lonicerae, Fructus Forsythiae.

The Radix Paeoniae Alba: be the dry root of dicotyledon ranunculaceae plant Radix Paeoniae PaeonialactifloraPall..Nature and flavor: cool, picric acid, is slightly cold.Effect: easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receives antiperspirant.Research shows: the paeoniflorin contained in the Radix Paeoniae Alba has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.This product energy nourishing the liver blood, holding back liver-yin, subduing the hyperfunction of the liver sun, dispersing liver-energy, can delay again that contraction is anxious, relieve the pain pain, is the good medicine of the various pain for the treatment of Liver Channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " purgation of spleen excess heat, only abdomen pain, sealing rushes down, and receives adverse flow of liver-QI pain, takes good care of conscience spleen channel blood, relax through sending down the abnormal ascending QI, only irritability pain." " herbal classic " Radix Paeoniae, though respectively in vain not red, the two is master to some extent respectively.So seek and unravel silk it and cure mainly all diseases, one is that replenishing blood and nourishing liver spleen is Kidney-Yin, and receives and take the photograph the at random of temper, and throwing off restraint of irritability is horizontal, then the Radix Paeoniae Alba.

Rhizoma Polygoni Cuspidati: be polygonaceae plant Rhizoma Polygoni Cuspidati PolygonumcuspidatumSieb.etZucc., dry rhizome and root.Spring, Qiu Erji excavate, and removing fibrous root, cleans, take advantage of short section of fresh-cut or sheet, dry.Nature and flavor: micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian.Effect: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.

Herba Lophatheri: be the dry stem and leaf of grass Herba Lophatheri LophatherumgracileBrongn..Nature and flavor: sweet, light, cold.GUIXIN, stomach, small intestine meridian.Effect: clearing heat and relieving fidgetness, diuresis.For calentura excessive thirst, hot urination drenches pain, aphtha of the mouth and tongue.Can clearing away heart-fire and antipyretic in this product, can fall small intestine fire and diuresis down, burning hot heresy can be made descending, from urine clearly, therefore can be used for the aphtha of the mouth and tongue of flaming up of heart-fire, and heat in the heart moves down the puckery pain of oliguria with reddish urine caused by small intestinal, often join Caulis Akebiae, the Radix Rehmanniae etc.Folium Bambusae is sweet trembles with fear into the heart, and can clear away heart-fire relieving restlessness, again can promoting the production of body fluid to quench thirst, and can the heresy of cool loose part of the body cavity above the diaphragm housing the heart and lungs wind heat, hinders, often join Gypsum Fibrosum, Radix Ophiopogonis, Radix Ginseng etc. for gas Tianjin two.

Radix Gentianae: be the dry root and rhizome of gentianaceae plant Gentiana manshurica GentianamanshuricaKitag., Radix Gentianae GentianascabraBunge, G. triflora Gentianatriflorapall or Gentiana rigescens Franch GentianarigescensFranch..Nature and flavor: bitter, cold.Return liver, gallbladder meridian.Effect: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.Being used for the treatment of jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, this product Great Cold, heat clearing and damp drying, outstanding kind liver heat removing gallbladder and damp-heat in lower-JIAO, is the common medicine of clearing liver-gallbladder and damp-heat in lower-JIAO.Normal and Cortex Phellodendri, Radix Sophorae Flavescentis are equal to be used.This product large bitter Great Cold, heat clearing and damp drying, outstanding kind liver heat removing gallbladder and damp-heat in lower-JIAO, be the common medicine of damp-heat in lower-JIAO, be used for the treatment of leukorrhagia eczema, swelling of the vulva pudendal pruritus often joins Radix Sophorae Flavescentis, Radix Scutellariae.

Herba Plantaginis: be the dry herb of Plantaginaceae plant Herba Plantaginis PlantagoasiaticaL. or Plantago depressa Willd PlantagodepressaWilld..Nature and flavor: sweet, cold.Return liver, kidney, lung, small intestine meridian.Effect: clearing away heat and promoting diuresis, eliminates the phlegm, removing heat from blood, removing toxic substances.For edema oliguria, the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.Herba Plantaginis has certain diuresis, and has antibacterial and effect that is antiinflammatory, and Herba Plantaginis water logging agent blocks bacterium etc. to Trichophyton concentricunm, ulotrichy microspore tinea bacterium, starlike slave in vitro inhibitory action in various degree.The flat board method that burrows proves that staphylococcus aureus is extremely sensitive to Herba Plantaginis, S. sonnei medium sensitivity, escherichia coli, bacillus pyocyaneus, Bacillus typhi slight sensitive.

Cortex Cinnamomi: be the bark of canella Cortex Cinnamomi CinnamomumcassiaPresl.Nature and flavor: hot greatly, pungent, sweet.Return kidney, spleen, the heart, Liver Channel.Effect: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow, promoting blood circulation.The sweet heat of this product, enters spleen kidney channel, and be good at YANG invigorating gas and warming the spleen and kidney, dispersing cold for relieving pain, the traditional Chinese medical science says that The mouth is the body opening or window of the spleen, and its China is at lip, and the strong then aphtha of spleen is from disappearing.

Radix Rehmanniae Preparata: for the tuber of scrophulariaceae rehmannia glutinosa plant (Rehmanniaglutinosa (Gdertn) Iibosch.exFisch.etMey.) forms through Processing methods.Nature and flavor: sweet, tepor.Return liver, kidney channel.Effect: nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.Radix Rehmanniae Preparata can be enriched blood YIN nourishing and liver-nourishing kidney-boosting, and all blood deficiency the moon loses, dizzy caused by deficiency of the liver and kindey, all can apply.Enrich blood often to be equal to Radix Angelicae Sinensis, the Radix Paeoniae Alba and use; Invigorating the liver and kidney normal being equal to Fructus Corni, is used.In addition, as joined the product such as Radix Codonopsis, Semen Ziziphi Spinosae, Poria, can be used for cardiopalmus, insomnia; Join the medicines such as Radix Angelicae Sinensis, the Radix Paeoniae Alba, CHUANSHAO, Rhizoma Cyperi, availablely control menoxenia; Join Colla Corii Asini, Radix Angelicae Sinensis, the Radix Paeoniae Alba etc., can be used for metrorrhagia.This product nourishing kidney tonifying YIN, is applicable to the various diseases caused by deficiency of kidney yin, and the normal and compatibility such as Fructus Corni, Cortex Moutan is applied; As belonged to the disease such as hyperactivity of fire caused by deficiency of YIN, osteopyrexia and fever, can be equal to Carapax et Plastrum Testudinis, the Rhizoma Anemarrhenae, Cortex Phellodendri and using.

Medulla Tetrapanacis: be the dry stem pith of Araliaceae rice-paper plant Tetrapanaxpapyriferus (Hook.) K.Koch.Nature and flavor: sweet, light, be slightly cold.Attach to the lung and stomach meridians.Effect: clear snobbish water; Lactogenesis.The puckery pain of main stranguria; Dysuria; Edema; Jaundice; Damp-warm diseases; Oliguria with reddish urine; Puerperal, breast was few; Amenorrhea; Leukorrhagia.Modern pharmacology is studied: Medulla Tetrapanacis has diuresis, and obviously can increase urine potassium output, has effects such as promoting galactopoiesis.Medulla Tetrapanacis polysaccharide has certain immunity moderation and antioxidative effect.

Radix Glycyrrhizae: the dry root and rhizome being glycyrrhizic legume GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. GlycyrrhizaInflataBat. or Glycyrrhiza glabra L. GlycyrrhizaGlabraL..Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.

Side's solution of the present invention is: Rhizoma Pinelliae drying dampness to eliminate phlegm, dissolving lump and resolving mass in side, Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication, Radix Ophiopogonis reinforcing stomach reg fluid, clear away heart-fire relieving restlessness, Radix Et Rhizoma Rhei removing pathogenic heat from blood and toxic substance from the body, Pseudobulbus Cremastrae Seu Pleiones heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, above Six-element is monarch drug altogether, damp and hot in kind clear body, and no matter upper, middle and lower are burnt, and blood system is warm or qifen fever all can be removed, and fundamentally removes the factor causing recurrent oral ulceration.Radix Achyranthis Bidentatae eliminating blood stasis and inducing menstruation, Herba Verbenae promoting blood circulation to remove blood stasis, Gypsum Fibrosum, Rhizoma Anemarrhenae clearing away heat-fire, relieving restlessness quench the thirst, Fructus Gardeniae clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, Herba Taraxaci, Herba Patriniae heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, above seven tastes are ministerial drug altogether, there is the effect of heat-clearing and toxic substances removing, anti-inflammation more, not only there is the function strengthening monarch drug drug effect, also there is the effect of broad-spectrum antiseptic, face, patient oral cavity pain, red and swollen phenomenon can be eliminated fast, slow down the symptom of patient, alleviate the misery of patient, and then reach the object for the treatment of.Rhizoma Paridis heat-clearing and toxic substances removing, reducing swelling and alleviating pain, Cortex Moutan clearing away heat and cooling blood, Radix Paeoniae Alba yin fluid astringing receives antiperspirant, the analgesic therapy of Rhizoma Polygoni Cuspidati dissipating blood stasis, Herba Lophatheri clearing heat and relieving fidgetness, Radix Gentianae heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire, Herba Plantaginis clearing away heat and promoting diuresis, Cortex Cinnamomi let the fire back to its origin, Radix Rehmanniae Preparata nourishing YIN and supplementing blood, the clear snobbish water of Medulla Tetrapanacis, a few taste is altogether for adjuvant drug not only strengthens the effect of monarch, ministerial drug eliminating damp-heat, promoting tissue regeneration and ulcer healing above, also has clearing away heat and promoting diuresis, the effect of pathogenic fire reducing relieving restlessness, let the fire back to its origin, treatment recurrent oral ulceration.Radix Glycyrrhizae priming return through, coordinating the actions of various ingredients in a prescription is for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, and have eliminating damp-heat, promoting tissue regeneration and ulcer healing, clear away heart-fire relieving restlessness, and effect of spleen invigorating eliminating dampness by diuresis effectively can treat recurrent oral ulceration.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Rhizoma Pinelliae 7-17 part, Rhizoma Coptidis 3-9 part, Radix Ophiopogonis 7-17 part, Radix Et Rhizoma Rhei 5-15 part, Pseudobulbus Cremastrae Seu Pleiones 15-25 part, Radix Scutellariae 7-17 part, Radix Achyranthis Bidentatae 10-20 part, Herba Verbenae 10-20 part, Gypsum Fibrosum 19-29 part, Rhizoma Anemarrhenae 7-17 part, Fructus Gardeniae 7-17 part, Herba Taraxaci 15-25 part, Herba Patriniae 15-25 part, Rhizoma Paridis 10-20 part, Cortex Moutan 7-17 part, Radix Paeoniae Alba 10-20 part, Rhizoma Polygoni Cuspidati 13-23 part, Herba Lophatheri 7-17 part, Radix Gentianae 4-14 part, Herba Plantaginis 13-23 part, Cortex Cinnamomi 4-14 part, Radix Rehmanniae Preparata 13-23 part, Medulla Tetrapanacis 3-9 part, Radix Glycyrrhizae 1-5 part.

Wherein be preferably: the Rhizoma Pinelliae 12 parts, Rhizoma Coptidis 6 parts, Radix Ophiopogonis 12 parts, Radix Et Rhizoma Rhei 10 parts, Pseudobulbus Cremastrae Seu Pleiones 20 parts, Radix Scutellariae 12 parts, Radix Achyranthis Bidentatae 15 parts, Herba Verbenae 15 parts, Gypsum Fibrosum 24 parts, the Rhizoma Anemarrhenae 12 parts, Fructus Gardeniae 12 parts, Herba Taraxaci 20 parts, Herba Patriniae 20 parts, Rhizoma Paridis 15 parts, Cortex Moutan 12 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Polygoni Cuspidati 18 parts, Herba Lophatheri 12 parts, Radix Gentianae 9 parts, Herba Plantaginis 18 parts, Cortex Cinnamomi 9 parts, Radix Rehmanniae Preparata 18 parts, Medulla Tetrapanacis 6 parts, Radix Glycyrrhizae 3 parts.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug pulverize mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.

A kind of preparation method for the treatment of the Chinese medicine preparation of recurrent oral ulceration is as follows:

Step one: by weight proportion of the present invention, takes Fructus Gardeniae bundle and becomes medicated bag, is put in water and soaks about 45 minutes, filters, for subsequent use;

Step 2: by weight proportion of the present invention, take Rhizoma Coptidis, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Achyranthis Bidentatae, the Rhizoma Anemarrhenae, Rhizoma Paridis, Cortex Moutan, the Radix Paeoniae Alba, Rhizoma Polygoni Cuspidati, Radix Gentianae, Cortex Cinnamomi, Radix Rehmanniae Preparata and the Gypsum Fibrosum wrapped, put into marmite, add cold water and exceed powder 3 ~ 6 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 4 cm is added in residue medicinal residues, then the Rhizoma Pinelliae is added, Pseudobulbus Cremastrae Seu Pleiones, Herba Verbenae, Herba Taraxaci, Herba Patriniae, Herba Lophatheri, Herba Plantaginis, Medulla Tetrapanacis, medicated bag in Radix Glycyrrhizae and step one decocts 15-25 minute, filter, obtain filtrate, for subsequent use,

Step 3: twice filtrate of gained in step 2 is merged, stirs, both the Chinese medicine decoction for the treatment of recurrent oral ulceration of the present invention.

Medicine of the present invention has eliminating damp-heat, promoting tissue regeneration and ulcer healing, and clear away heart-fire relieving restlessness, effect of spleen invigorating eliminating dampness by diuresis, and good effect, the time is short, not easily recurs, cheap, the mode that this Chinese medicine preparation adopts is treated and effectively can be treated recurrent oral ulceration, alleviates the slight illness of patient, adds up according to clinical 150 routine patient view, use medicine of the present invention the total effective rate course for the treatment of 90%, two the total effective rate course for the treatment of 98%.

Detailed description of the invention

Embodiment one, the Rhizoma Pinelliae 7 parts, Rhizoma Coptidis 3 parts, Radix Ophiopogonis 7 parts, Radix Et Rhizoma Rhei 5 parts, Pseudobulbus Cremastrae Seu Pleiones 15 parts, Radix Scutellariae 7 parts, Radix Achyranthis Bidentatae 10 parts, Herba Verbenae 10 parts, Gypsum Fibrosum 19 parts, the Rhizoma Anemarrhenae 7 parts, Fructus Gardeniae 7 parts, Herba Taraxaci 15 parts, Herba Patriniae 15 parts, Rhizoma Paridis 10 parts, Cortex Moutan 7 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Polygoni Cuspidati 13 parts, Herba Lophatheri 7 parts, Radix Gentianae 4 parts, Herba Plantaginis 13 parts, Cortex Cinnamomi 4 parts, Radix Rehmanniae Preparata 13 parts, Medulla Tetrapanacis 3 parts, Radix Glycyrrhizae 1 part.

Embodiment two, the Rhizoma Pinelliae 12 parts, Rhizoma Coptidis 6 parts, Radix Ophiopogonis 12 parts, Radix Et Rhizoma Rhei 10 parts, Pseudobulbus Cremastrae Seu Pleiones 20 parts, Radix Scutellariae 12 parts, Radix Achyranthis Bidentatae 15 parts, Herba Verbenae 15 parts, Gypsum Fibrosum 24 parts, the Rhizoma Anemarrhenae 12 parts, Fructus Gardeniae 12 parts, Herba Taraxaci 20 parts, Herba Patriniae 20 parts, Rhizoma Paridis 15 parts, Cortex Moutan 12 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Polygoni Cuspidati 18 parts, Herba Lophatheri 12 parts, Radix Gentianae 9 parts, Herba Plantaginis 18 parts, Cortex Cinnamomi 9 parts, Radix Rehmanniae Preparata 18 parts, Medulla Tetrapanacis 6 parts, Radix Glycyrrhizae 3 parts.

Embodiment three, the Rhizoma Pinelliae 17 parts, Rhizoma Coptidis 9 parts, Radix Ophiopogonis 17 parts, Radix Et Rhizoma Rhei 15 parts, Pseudobulbus Cremastrae Seu Pleiones 25 parts, Radix Scutellariae 17 parts, Radix Achyranthis Bidentatae 20 parts, Herba Verbenae 20 parts, Gypsum Fibrosum 29 parts, the Rhizoma Anemarrhenae 17 parts, Fructus Gardeniae 17 parts, Herba Taraxaci 25 parts, Herba Patriniae 25 parts, Rhizoma Paridis 20 parts, Cortex Moutan 17 parts, the Radix Paeoniae Alba 20 parts, Rhizoma Polygoni Cuspidati 23 parts, Herba Lophatheri 17 parts, Radix Gentianae 14 parts, Herba Plantaginis 23 parts, Cortex Cinnamomi 14 parts, Radix Rehmanniae Preparata 23 parts, Medulla Tetrapanacis 9 parts, Radix Glycyrrhizae 5 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Treatment Blood of Patients with Recurrent Oral 150 example.Wherein male 71 example, women 79 example, M-F 1:1.1, max age 73 years old, minimal ages 12 years old, patient's course of disease time, not etc. every basic documents such as patient age, sex, the course of disease were substantially not identical.

Two, diagnostic criteria:

1, the diagnostic criteria in national state-compiled textbook " oral medicine " is met.Course of disease > 6 months, recurrent exerbation, monthly shows effect 1 ~ 2 time.

2, get rid of other diseases of oral mucosa, and patient is without serious whole body illness.

3, patient does not take the medicine of any treatment oral ulcer in 1 month, and this morbidity is to medical front without any treatment.

4, medical in morbidity 3 days.

Three, Therapeutic Method:

According to Medications Example two of the present invention, and decoction prepared by selected preparation method, every day potion, twice daily, decoction being taken warmly 10th is a course for the treatment of.

Four, efficacy assessment standard:

With reference to Chinese stomatology meeting " recurrent oral ulceration therapeutic evaluation tentative standard ".

1, cure: clinical symptoms disappears completely, oral ulcer stops recurrence more than 1 year;

2, take a turn for the better: clinical symptoms takes a turn for the better to some extent, total intermittent time extends, and total ulcer number reduces;

3, invalid: clinical symptoms even increases the weight of without any improvement, total intermittent time and total ulcer number are all without change.

Five, therapeutic outcome statistics

According to statistical result showed, Chinese medicine of the present invention has good clinical effectiveness at treatment recurrent oral ulceration, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.

Model case and curative effect:

Case one, patient's fourth, man, 30 years old, patient's oral lesions, pain, and with dry mouth and parching tongue, frequent recurrent exerbation, excited is more very, serious image is to the appetite of patient and mood, patient takes Western medicine repeatedly, but soon the state of an illness always repeatedly, patient determines the Therapeutic Method adopting Chinese medicine, select made preparation in the embodiment of the present invention two, and selected preparation method, after using a course for the treatment of, symptom alleviates, the degree of festering is clearly better, pain symptom is alleviated, for preventing recurrence, after carried out again a period of time treatment after symptom eliminate, recurrent oral ulceration and lingual surface are completely normal, Effect of follow-up visit by telephone 1 year, there is not recurrence, recovery from illness.

Case two, patient Zhang, female, 22 years old, repeatedly there is oral ulcer symptom in patient, often to get well and to rise, take repeatedly common medicine, but cure the symptoms, not the disease, cause patient pain unbearably, so remove examination in hospital, finally be diagnosed as recurrent oral ulceration, patient selects the Therapeutic Method with Chinese medicine, adopt made preparation in the embodiment of the present invention two, and selected preparation method, twice daily, after patient takes a course for the treatment of, symptom alleviates, the degree of festering is clearly better, pain symptom alleviates, hold on after taking two courses for the treatment of, recurrent oral ulceration heals, lingual surface is smooth ruddy, also have no repeatedly time nervous, Effect of follow-up visit by telephone 1 year, have no recurrence, recovery from illness.

Case three, patient week certain, female, 41 years old, patient is short-tempered at ordinary times, easily get angry, since nearly half a year, the frequent recurrent exerbation of oral ulcer, patient adopts various Drug therapy, but often cure the symptoms, not the disease, patient is through making some inquiries about, and here was treated afterwards, adopt made preparation in the embodiment of the present invention two, and selected preparation method, every day, after patient uses two courses for the treatment of, pain disappears, heal in skin ulcer face, for preventing recurrence, patient adheres to again having taken a course for the treatment of, Effect of follow-up visit by telephone 1 year, have no recurrence, recovery from illness.

Claims (4)

1. treat the Chinese medicine preparation of recurrent oral ulceration for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Rhizoma Pinelliae 7-17 part, Rhizoma Coptidis 3-9 part, Radix Ophiopogonis 7-17 part, Radix Et Rhizoma Rhei 5-15 part, Pseudobulbus Cremastrae Seu Pleiones 15-25 part, Radix Scutellariae 7-17 part, Radix Achyranthis Bidentatae 10-20 part, Herba Verbenae 10-20 part, Gypsum Fibrosum 19-29 part, Rhizoma Anemarrhenae 7-17 part, Fructus Gardeniae 7-17 part, Herba Taraxaci 15-25 part, Herba Patriniae 15-25 part, Rhizoma Paridis 10-20 part, Cortex Moutan 7-17 part, Radix Paeoniae Alba 10-20 part, Rhizoma Polygoni Cuspidati 13-23 part, Herba Lophatheri 7-17 part, Radix Gentianae 4-14 part, Herba Plantaginis 13-23 part, Cortex Cinnamomi 4-14 part, Radix Rehmanniae Preparata 13-23 part, Medulla Tetrapanacis 3-9 part, Radix Glycyrrhizae 1-5 part.

2. the Chinese medicine preparation for the treatment of recurrent oral ulceration according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: the Rhizoma Pinelliae 12 parts, Rhizoma Coptidis 6 parts, Radix Ophiopogonis 12 parts, Radix Et Rhizoma Rhei 10 parts, Pseudobulbus Cremastrae Seu Pleiones 20 parts, Radix Scutellariae 12 parts, Radix Achyranthis Bidentatae 15 parts, Herba Verbenae 15 parts, Gypsum Fibrosum 24 parts, the Rhizoma Anemarrhenae 12 parts, Fructus Gardeniae 12 parts, Herba Taraxaci 20 parts, Herba Patriniae 20 parts, Rhizoma Paridis 15 parts, Cortex Moutan 12 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Polygoni Cuspidati 18 parts, Herba Lophatheri 12 parts, Radix Gentianae 9 parts, Herba Plantaginis 18 parts, Cortex Cinnamomi 9 parts, Radix Rehmanniae Preparata 18 parts, Medulla Tetrapanacis 6 parts, Radix Glycyrrhizae 3 parts.

3. the Chinese medicine preparation for the treatment of recurrent oral ulceration according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.

4. treat a preparation method for the Chinese medicine preparation of recurrent oral ulceration, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, takes Fructus Gardeniae bundle and becomes medicated bag, is put in water and soaks about 45 minutes, filters, for subsequent use, step 2: by weight proportion of the present invention, take Rhizoma Coptidis, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Achyranthis Bidentatae, the Rhizoma Anemarrhenae, Rhizoma Paridis, Cortex Moutan, the Radix Paeoniae Alba, Rhizoma Polygoni Cuspidati, Radix Gentianae, Cortex Cinnamomi, Radix Rehmanniae Preparata and the Gypsum Fibrosum wrapped, put into marmite, add cold water and exceed powder 3 ~ 6 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 4 cm is added in residue medicinal residues, then the Rhizoma Pinelliae is added, Pseudobulbus Cremastrae Seu Pleiones, Herba Verbenae, Herba Taraxaci, Herba Patriniae, Herba Lophatheri, Herba Plantaginis, Medulla Tetrapanacis, medicated bag in Radix Glycyrrhizae and step one decocts 15-25 minute, filter, obtain filtrate, for subsequent use, step 3: twice filtrate of gained in step 2 is merged, stirs, both the Chinese medicine decoction for the treatment of recurrent oral ulceration of the present invention.