CN104324350A - Traditional Chinese medicine composition for chronic colitis and preparation method of traditional Chinese medicine composition - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine composition for chronic colitis. The traditional Chinese medicine composition consists of notoginseng powder, honeysuckle, scutellaria baicalensis, fructus forsythiae, Agastache rugosus, rhizoma atractylodis, eupatorium, fructus amomi, nutmeg, Amomum tsao-ko, seeds of Job's tears, rhizoma alismatis, Turnjujube, monkshood, rhizoma zingiberis, fructus evodiae, piper cubeba, pericarpium citri reticulatae viride, bighead atractylodes rhizome, Codonopsis pilosula and honey-fried licorice root according to a certain weight ratio. The traditional Chinese medicine composition has the effects of clearing heat and dissipating stasis, eliminating dampness and warming middle-Jiao, warming spleen and stopping diarrhea and eliminating cold to stop pain and can be used for effectively treating chronic colitis.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for chronic colitis.The invention still further relates to the preparation method of this Chinese medicine composition.
Background technology
Chronic colitis be a kind of chronic, repeatability, multiple with colon, sigmoid colon and rectum for site of pathological change.Refer to that rectum colon causes the inflammatory edema of intestinal, ulcer, hemorrhage pathological changes because of various pathogenesis.Chronic colitis is that chronic colon is divided into specificity according to pathogenesis usually, namely has the colitis of obvious cause, and the non-specific colitis that namely pathogenesis is not clear.After conventional therapy medication, symptom can be eased, and symptom alleviates, and easily recurs after drug withdrawal.Concrete symptom is left lower quadrant pain, diarrhoea, tenesmus, time be just stained with down liquid, constipation or have loose bowels alternately occur, fashion time bad, weight loss, become thin, lassitude, touching lower disconnected, recurrent exerbation.
The course of disease of chronic colitis is longer, pathogenic factor variation, and the cause of disease is difficult to determine, therefore treatment is got up more difficult, and doctor trained in Western medicine carries out anti-inflammatory analgetic, anti-infective therapy to this sick main antibiotic that uses.According to traditional Chinese medical science organic conception, can for different pathogeny, multi-angle is treated, and plays the advantage of differentiation of tcm, thus evident in efficacy.Because primary disease has simulataneous insufficiency and excessive, coldheat complex, the Liver and kidney taste of conditioning patient, strengthen the body constitution of people, reach the object of body disease-resistant poison with this.
At present, in the treatment of chronic colitis, lighter for the state of an illness, more oral medicines can be treated, but most medicine belongs to chemical drugs, although antiinflammatory can be removed painful for the moment, cure the symptoms, not the disease, easily cause repeatedly, and chemical drugs all has side effect in various degree, if the course of disease is with the passing of time, in erosive or ulcerative colitis be then difficult to treatment, changeable, great misery is brought to patient, some must carry out open surgery, not only brings misery to patient, brings financial burden to again patient family.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has determined curative effect for treatment chronic colitis, and side effect is little, cheap, treating both the principal and secondary aspects of a disease, the feature not easily recurred.
Another object of the present invention is to provide this preparation method for the Chinese medicine preparation of chronic colitis.
Inventor is in clinical treatment practice for many years, observe the misery that chronic colitis is brought to patient, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of chronic colitis repeatedly, the present invention selects Radix Notoginseng powder, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Herba Pogostemonis, Rhizoma Atractylodis, Herba Eupatorii, Fructus Amomi, Semen Myristicae, Fructus Tsaoko, Semen Coicis, Rhizoma Alismatis, Semen Hoveniae (Fructus Hoveniae), Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, Fructus Evodiae, Fructus Litseae, Pericarpium Citri Reticulatae Viride, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Radix Glycyrrhizae Preparata combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is heat clearing away dissipating blood stasis, dampness warming middle-JIAO, warming spleen and stopping diarrha, effect of dispersing cold for relieving pain, thus effectively can treat chronic colitis.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Notoginseng powder: be the powder obtained by the air-dry pulverizing of dry root of panax araliaceae plant Panax notoginseng (Burk.) F. H. Chen.Nature and flavor: sweet, micro-hardship, temperature.Return liver, stomach warp.Effect: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.Record in " book on Chinese herbal medicine is looked for the truth ": Radix Notoginseng, common people only know that function is stopped blooding bitterly, hardly realize bitterly because blood stasis then aches work, and blood is because only applying loose then blood.The bitter temperature of Radix Notoginseng abnormal smells from the patient, can in its blood stasis of blood systemization.
Flos Lonicerae: the flower that dry flower or band for caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera dasystyla Rehd. are just opened.Nature and flavor: sweet, cold.Return lung, the heart, stomach warp.Effect: heat-clearing and toxic substances removing, wind-dispelling heat-dissipating.This product is sweet in flavor and cold in property, can heat-clearing and toxic substances removing, again kind loose carbuncle detumescence, for treating the key medicine of all YANG syndrome carbuncle furuncle.Ancient prescription is recorded, and Flos Lonicerae controls all toxic swellings, pays no attention to and does not burst, or from the beginning of heating, and furuncle inguinal bubo.
Radix Scutellariae: be the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Nature and flavor: bitter, cold.Return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.The clinical practice of Radix Scutellariae is antibacterial relatively good, and does not develop immunity to drugs.This product has the merit of clearing away heat and cooling blood hemostasis, intimately flourishing with controlling, and the haematemesis of the absurd row of forcing blood, metrorrhagia, has blood in stool.
Fructus Forsythiae: be the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.Nature and flavor: bitter, are slightly cold.Return lung, the heart, small intestine meridian.Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.Fructus Forsythiae is normal with the same use of Flos Lonicerae, Fructus Forsythiae bitter in the mouth cool in nature, gently clearly to float, and can control all heat of the part of the body cavity above the diaphragm housing the heart and lungs, outstanding energy removing toxicity for eliminating carbuncles and eliminating stagnation, therefore is the key medicine of persons particularly liable to develop skin infection.Fructus Forsythiae has broad-spectrum antibacterial action, has very strong inhibitory action to staphylococcus aureus, Hayes dysentery bacterium, has certain inhibitory action to other pathogenic bacterium, influenza virus, fungus.There is antiinflammatory action.Antibacterial action: Fructus Forsythiae concentrated decotion has antibacterial action in vitro, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.
Herba Pogostemonis: be the herb of labiate Herba Pogostemonis Cablin Potchouli Herb or Herba Pogostemonis Wrinkled Gianthyssop Herb.Nature and flavor: pungent, tepor.Return lung, spleen, stomach warp.Effect: fast gas, and in, ward off dirty, damp eliminating.Cure cold heat-damp in summer, cold and heat, and headache, breast gastral cavity painful abdominal mass is vexed, and vomiting is had loose bowels, malaria, dysentery, halitosis.
Rhizoma Atractylodis: be the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodes lancea (Thunb.) DC. or Atractylis chinensis Atractylodes chinensis (DC.) Koidz..Nature and flavor: pungent, bitter, temperature; Return spleen, stomach, Liver Channel; Effect: drying damp and strengthening spleen, expelling wind and cold, improving eyesight; This product toil is warm in nature, and virtue is strong dry loose, and can rise and can fall, walk and do not keep, can be that damp is removed and recovers the transportation capabilities of spleen.
Herba Eupatorii: be the dry aerial parts of feverfew Herba Eupatorii Eupatorium fortunei Turcz..Nature and flavor: pungent are flat.Return spleen, stomach, lung meridian.Effect: removing dampness by means of aromatics, appetizing of being amusing, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.Treatment hygropyrexia disease key medicine, the medicine fit applications such as normal and Herba Pogostemonis, Radix Scutellariae, Semen Coicis.
Fructus Amomi: be the dry mature fruit of zingiberaceous plant Fructus Amomi Amomum villosum Lour., green shell sand Amomum villosum Lour. var. xanthioides T. L. Wu et Senjen or SEMEN AMOMI LONGILIGULA Amomum longiligulare T. L. Wu.Nature and flavor: pungent, warm.Return spleen, stomach, kidney channel.Effect: removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.The inappetence caused for dampness taste and vomiting such as to be had loose bowels the disease, and the normal Bai of cooperation Intraoperative, Pericarpium Citri Reticulatae is equivalent uses.
Semen Myristicae: be the dry kernel of Myristicaceae Nutmeg Vegetable meat Fructus Amomi Rotundus Myristica fragrans Houtt..Nature and flavor are pungent, temperature.Return spleen, stomach, large intestine channel.Effect: warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents.For Deficiency and coldness of spleen and stomach, incessant chronic diarrhea, abdominal distention, lack of appetite is vomitted." Amplification on Materia Medica addendum ": Semen Myristicae, warming middle-JIAO spleen reinforcing is ball.Solar corona claims its therapeutic method to keep the adverse QI flowing downwards, must mend and kind transporting with its spleen, gas under also, if non-Pericarpium Citri Reticulatae, Rhizoma Cyperi Zhi Jue let out.
Fructus Tsaoko: be the dry mature fruit of zingiberaceous plant Fructus Tsaoko Amomum tsao-ko Crevost et Lemaire.Nature and flavor: pungent, warm.Return spleen, stomach warp.Effect: dampness warming middle-JIAO, expectorant preventing the attack (or recurrence) of malaria.For internal retention of cold wetness, abdominal distention, feeling of fullness is vomitted, malaria cold and heat.For stagnation of cold-damp taste, distension and fullness in the abdomen; The disease such as pain and vomiting and diarrhoea, can be equal to Semen Myristicae and use.
Semen Coicis: be the dry mature kernal of grass Semen Coicis Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf.Nature and flavor: sweet, light, cool.Return spleen, stomach, lung meridian.Effect: spleen invigorating eliminating dampness by diuresis, eliminating impediment pain relieving, clearing away heat and discharging pus.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.This product is used for the disease of retention of damp-heat in the interior.
Rhizoma Alismatis: be the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Nature and flavor: sweet, cold.Return kidney, urinary bladder channel.Effect: diuresis, clearing away damp-heat.For edema, the dysuria of retention of water-damp in the body.This product enters kidney, urinary bladder channel, and kind clear damp-heat in lower-JIAO cold in nature, is used for syndrome of dampness-heat in lower jiao.
Semen Hoveniae (Fructus Hoveniae): this product is the dry mature seed of Rhamnaceae plant Semen Hoveniae (Fructus Hoveniae) Hovenia dulcis Thunb..Nature and flavor: sweet in the mouth; Property is put down.GUIXIN; Spleen; Lung meridian.Effect: alcoholic intoxication; To quench the thirst relieving restlessness; Preventing or arresting vomiting; Profit defecation.Main drunk; Excessive thirst; Vomiting; Difficulty in urination and defecation.Supplement to the Herbal: relieving restlessness of quenching the thirst, moistening five ZANG-organs, sharp defecation, go heat on diaphragm, function is as honey.
Radix Aconiti Lateralis Preparata: be the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx..Nature and flavor are pungent, sweet, hot greatly; Poisonous.GUIXIN, kidney, spleen channel.Effect: recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispersing cold for relieving pain.For YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.The large heat of this product, cold relieving power is strong, therefore can control inward invasion of pathogenic cold stomach abdomen pain, have loose bowels, and the arthralgia pain of Cold-dampness.
Rhizoma Zingiberis: be the dry rhizome of zingiber Zingiber officinale Rosc..Nature and flavor: pungent, hot.Return spleen, stomach, the heart, lung meridian.Effect: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.Product hot dry strong, main enter taste warp, be longer than warm middle burnt spleen sun and cold expelling, therefore all middle burnt cold syndrome, the excess-cold syndrome of no matter invading in exogenous cold, or the deficiency-cold syndrome of YANG QI deficiency, be key medicine.
Fructus Evodiae: be rutaceae Fructus Evodiae Evodia rutaecarpa(Juss.) Benth., Shi Hu Evodia rutaecarpa(Juss.) the dry almost ripe fruit of Benth. var. officinalis (Dode) Huang or thin hair Fructus Evodiae Evodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang.Nature and flavor: pungent, bitter, heat; Slightly poisonous.Return liver, spleen, stomach, kidney channel.Effect: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, abdominal distention, vomiting acid regurgitation, Diarrhoea, this product temperature energy reinforcing spleen and kidney, supporing yang antidiarrheal, for controlling the common medicine of deficiency of spleen-YANG and kidneyYANG, Diarrhoea.Often join Rhizoma Zingiberis Recens etc.
Fructus Litseae: be the dry mature fruit of canella cubeb litsen tree Litsea cubeba (Lour.) Pers..Nature and flavor: pungent, temperature.Return spleen, stomach, kidney, urinary bladder channel.Effect: warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain.For cold syndrome of the stomach vomiting, coldness and pain in the epigastrium, colic of cold type is suffered from abdominal pain, stagnancy of cold-damp, turbid urine.The peaceful Fructus Litseae of pharmaceutical research table also has broad-spectrum antiseptic and kills the effect of fungus.
Pericarpium Citri Reticulatae Viride: be rutaceae orange Citrus reticulata Blanco and the dry young fruit of variety thereof or the peel of immature fruit.Nature and flavor are bitter, pungent, warm.Enter liver, gallbladder, stomach warp.Effect: soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.For costa sternales gastral cavity distending pain, acute mastitis, colic, stagnation of QI due to dyspepsia.
The Rhizoma Atractylodis Macrocephalae: be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, the Rhizoma Atractylodis Macrocephalae can air making-up and spleen enlivening, again can dampness diuretic, is the key medicine of the spleen strengthening and damp drying.
Radix Codonopsis: be the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis Codonopsis pilosula Nannf.var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Nature and flavor: sweet, flat.Return spleen, lung meridian.Effect: mend strengthening spleen and lung, nourishing blood to promote the production of body fluid.For deficiency of the spleen and lung, breathe hard, cardiopalmus, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst." Bencao Congxin " is recorded: invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.Middle feeble QI is weak, mends in order to adjust, very smooth and proper.
Radix Glycyrrhizae Preparata: Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Radix Glycyrrhizae Preparata is that processed goods smoked by the honey of Radix Glycyrrhizae.Nature and flavor are sweet, flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.
Side's solution of the present invention is: Radix Notoginseng powder dissipating blood stasis hemostasis in side, subduing swelling and relieving pain, Flos Lonicerae, Fructus Forsythiae heat-clearing and toxic substances removing, anti-inflammation, Radix Astragali heat clearing and damp drying, Herba Pogostemonis damp eliminating and in, the above five tastes are monarch drug altogether, first Radix Notoginseng powder eliminating stasis to stop pain, bitterly because blood stasis then aches work, blood is because only applying loose then blood, the pain that reduction of patient causes because of congestion in enteric cavity from fundamental symptoms, Flos Lonicerae and Fructus Forsythiae share not only heat-clearing and toxic substances removing, and both share the effect of the anti-inflammation of increase, expand antibacterial scope, Radix Scutellariae and Herba Pogostemonis heat clearing and damp drying, eliminate the excess-heat symptom in patient body on the whole, the slight illness of reduction of patient.Rhizoma Atractylodis are drying damp and strengthening spleen, Herba Eupatorii removing dampness by means of aromatics, appetizing of being amusing, Fructus Amomi removing dampness appetizing, warming spleen and stopping diarrha, Semen Myristicae, Fructus Tsaoko dampness warming middle-JIAO, relieving diarrhea with astringents, Semen Coicis spleen invigorating eliminating dampness by diuresis, above Six-element is ministerial drug altogether, while assistance monarch drug heat clearing and damp drying, ministerial drug also has warming spleen and stopping diarrha effect, controls the situation of patient's diarrhoea from clinical symptoms, and above a few taste is amusing appetizing in addition, nurse one's health the health of patient on the whole, increase the appetite of patient, and the absorption of nutrient substance, promote the recovery of patient body.Rhizoma Alismatis, Semen Hoveniae (Fructus Hoveniae) heat clearing away are convenient, supporing yang, the dispersing cold for relieving pain of fire mended by Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis recuperating depleted YANG is promoted blood circulation, dampness expectorant, Fructus Evodiae, Fructus Litseae are supporing yang antidiarrheal, warming spleen and stomach for dispelling cold, Pericarpium Citri Reticulatae Viride depressed liver-energy dispersing and QI regulating, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, Radix Codonopsis mends strengthening spleen and lung, nourishing blood to promote the production of body fluid, and above a few taste is adjuvant drug altogether, have more and mend effect that is fiery supporing yang, dispersing cold for relieving pain, unbalance in conditioning patient body, the kidney invigorating and essence nourishing, strengthens the basic recovery of patient body, relax drug effect, reduce injury to patient body, Radix Glycyrrhizae Preparata spleen reinforcing stomach function regulating, coordinating the actions of various ingredients in a prescription, priming return through, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, have effect of heat clearing away dissipating blood stasis, dampness warming middle-JIAO, warming spleen and stopping diarrha, dispersing cold for relieving pain, effectively can treat chronic colitis.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Notoginseng powder 1-5 part, Flos Lonicerae 15-25 part, Radix Scutellariae 10-20 part, Fructus Forsythiae 13-23 part, Herba Pogostemonis 10-20 part, Rhizoma Atractylodis 10-20 part, Herba Eupatorii 7-17 part, Fructus Amomi 3-9 part, Semen Myristicae 3-9 part, Fructus Tsaoko 4-14 part, Semen Coicis 25-35 part, Rhizoma Alismatis 10-20 part, Semen Hoveniae (Fructus Hoveniae) 10-20 part, Radix Aconiti Lateralis Preparata 10-20 part, Rhizoma Zingiberis 13-23 part, Fructus Evodiae 3-9 part, Fructus Litseae 1-5 part, Pericarpium Citri Reticulatae Viride 7-17 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Radix Codonopsis 10-20 part, Radix Glycyrrhizae Preparata 4-14 part.
Wherein be preferably: Radix Notoginseng powder 3 parts, Flos Lonicerae 20 parts, Radix Scutellariae 15 parts, Fructus Forsythiae 18 parts, Herba Pogostemonis 15 parts, Rhizoma Atractylodis 15 parts, Herba Eupatorii 12 parts, Fructus Amomi 6 parts, Semen Myristicae 6 parts, Fructus Tsaoko 9 parts, Semen Coicis 30 parts, Rhizoma Alismatis 15 parts, Semen Hoveniae (Fructus Hoveniae) 15 parts, Radix Aconiti Lateralis Preparata 15 parts, Rhizoma Zingiberis 18 parts, Fructus Evodiae 6 parts, Fructus Litseae 3 parts, 12 parts, Pericarpium Citri Reticulatae Viride, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Codonopsis 15 parts, Radix Glycyrrhizae Preparata 9 parts.
Medicine of the present invention adopts herbal enema method, that medicine juice to be gone directly disease institute by coloclysis, Chinese medicinal herbs decoction is absorbed by rectal venous plexus, therefore herbal retention enema can play local application, effect of through focus, higher concentration can be had in lesion, thus play desirable therapeutic effect, avoid effective ingredient to be subject to gastric acid simultaneously, Digestive system, drug effect is reduced with the destruction of liver, and dosage is few, concentration is high, rapid-action, good effect, toxic and side effects is few, compensate for the deficiency of oral administration, be conducive to the raising keeping pharmaceutical properties and curative effect, avoid or alleviate the infringement of medicine to Liver and kidney.
Chinese medicine preparation of the present invention, its preparation method is as follows:
Step one: according to weight proportion of the present invention, binds up with gauze Fructus Forsythiae, Fructus Amomi, Semen Myristicae, Fructus Tsaoko, Semen Coicis, Semen Hoveniae (Fructus Hoveniae), Fructus Evodiae, Fructus Litseae, Pericarpium Citri Reticulatae Viride, is put in water and soaks about 45 minutes, filters, for subsequent use;
Step 2: by weight proportion of the present invention, take Radix Scutellariae, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis put into marmite, add after soaking in step one and remain cold water, add water and exceed powder 2-4 centimetre, after being fried boiling with high heat, again with 30 minutes at a simmer, filter, obtain filtrate, the water of 3 cm is added in residue medicinal residues, continuation decoction about 20 minutes, then adds a kind of medicated bag of step and Herba Pogostemonis, Herba Eupatorii, Rhizoma Alismatis, Radix Glycyrrhizae Preparata continue decoction 30 minutes, finally adds Flos Lonicerae and decocts 10 minutes, filter, waste, merges twice filtrate, for subsequent use;
Step 3: left standstill, get supernatant by gained medicinal liquid in step 2, concentrated, add Radix Notoginseng powder, stir, subpackage sterilizing obtains coloclysis medicament.
Using method of the present invention: the enema mixture obtained according to formula of the present invention, pours into from anus at twice, each 100ml, gets buttocks and raises position, medicinal liquid is all entered and does not get rid of, and within 7 days, is a course for the treatment of.
Medicine of the present invention has the effects such as heat clearing away dissipating blood stasis, dampness warming middle-JIAO, warming spleen and stopping diarrha, dispersing cold for relieving pain, and determined curative effect, side effect is little, cheap, treating both the principal and secondary aspects of a disease, not easily recurs, and adds up according to clinical 160 routine patient view, use medicine of the present invention the total effective rate course for the treatment of 85%, two the total effective rate course for the treatment of 97.5%.
Detailed description of the invention
Embodiment one, Radix Notoginseng powder 1 part, Flos Lonicerae 15 parts, Radix Scutellariae 10 parts, Fructus Forsythiae 13 parts, Herba Pogostemonis 10 parts, Rhizoma Atractylodis 10 parts, Herba Eupatorii 7 parts, Fructus Amomi 3 parts, Semen Myristicae 3 parts, Fructus Tsaoko 4 parts, Semen Coicis 25 parts, Rhizoma Alismatis 10 parts, Semen Hoveniae (Fructus Hoveniae) 10 parts, Radix Aconiti Lateralis Preparata 10 parts, Rhizoma Zingiberis 13 parts, Fructus Evodiae 3 parts, Fructus Litseae 1 part, 7 parts, Pericarpium Citri Reticulatae Viride, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Codonopsis 10 parts, Radix Glycyrrhizae Preparata 4 parts.
Embodiment two, Radix Notoginseng powder 3 parts, Flos Lonicerae 20 parts, Radix Scutellariae 15 parts, Fructus Forsythiae 18 parts, Herba Pogostemonis 15 parts, Rhizoma Atractylodis 15 parts, Herba Eupatorii 12 parts, Fructus Amomi 6 parts, Semen Myristicae 6 parts, Fructus Tsaoko 9 parts, Semen Coicis 30 parts, Rhizoma Alismatis 15 parts, Semen Hoveniae (Fructus Hoveniae) 15 parts, Radix Aconiti Lateralis Preparata 15 parts, Rhizoma Zingiberis 18 parts, Fructus Evodiae 6 parts, Fructus Litseae 3 parts, 12 parts, Pericarpium Citri Reticulatae Viride, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Codonopsis 15 parts, Radix Glycyrrhizae Preparata 9 parts.
Embodiment three, Radix Notoginseng powder 5 parts, Flos Lonicerae 25 parts, Radix Scutellariae 20 parts, Fructus Forsythiae 23 parts, Herba Pogostemonis 20 parts, Rhizoma Atractylodis 20 parts, Herba Eupatorii 17 parts, Fructus Amomi 9 parts, Semen Myristicae 9 parts, Fructus Tsaoko 14 parts, Semen Coicis 35 parts, Rhizoma Alismatis 20 parts, Semen Hoveniae (Fructus Hoveniae) 20 parts, Radix Aconiti Lateralis Preparata 20 parts, Rhizoma Zingiberis 23 parts, Fructus Evodiae 9 parts, Fructus Litseae 5 parts, 17 parts, Pericarpium Citri Reticulatae Viride, the Rhizoma Atractylodis Macrocephalae-25 parts, Radix Codonopsis 20 parts, Radix Glycyrrhizae Preparata 14 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Accept patient's totally 320 examples for medical treatment, patient is divided into observation group and matched group at random, wherein male 170 example, women 150 example, M-F 1.13:1, max age 76 years old, minimal ages 16 years old, 40 years old mean age, the course of disease a few natural life-span to some months not etc., average course of disease 3 months.Every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).
Two, diagnostic criteria
1, Recurrent Abdominal Pain, diarrhoea loose stool (or constipation), even there is the symptom of pus, blood in stool band mucus;
2, the light tenderness of hypogastric region limitation, hides at left lower quadrant or left abdomen, bowel sounds active, slightly can increase, become thin with body temperature, lustreless complexion, the underfed sign such as sallow;
3, stool routine examination show, leukocyte and a small amount of pus cell, do not find dysentery bacterium and ameba, and pathogenic bacterium are found in stool cultivation;
4, enteroscopy is shown in that intestinal mucosa has multiple erosion or shallow table ulcer, with the symptom of the chronic inflammatory diseases such as diffusivity hyperemia, edema or mucosa is coarse, mucosa blood vessel is fuzzy, proliferation of fibrous tissue, luminal stenosis.
Three, Therapeutic Method
1, observation group is according to Medications Example two of the present invention, and weighting raw materials (daily dose), decocts into 200 milliliters by dense for Chinese medicine, adopts clysmata.Every day 2 times 7th is a course for the treatment of.
2, matched group is according to the Chinese medicine decoction for the treatment of chronic colitis in CN 102631512 A, every day potion, twice daily, the Ureteral Calculus phase is 7 days.
Four, points for attention:
1, the emptying stool of patient is allowed before coloclysis.
2, fluid temperature should remain on 39 DEG C ~ 41 DEG C, too low enterokinesia is strengthened, stomachache aggravation, too high, cause intestinal mucosa to scald or dilatation of intestine, produce strong awareness of defecation, cause medicinal liquid time of staying in intestinal short, absorb less, weak effect, 39 DEG C ~ 41 DEG C these constant temperature act on focus has certain massage and the effect of local warming, expansible blood vessel, increases blood flow, play physiotherapy function and improve microcirculation, suppress connective tissue proliferation, promote that inflammation absorbs, also can dredge glandular tube, dissipation secretions, is conducive to disappearing of inflammation.
3, retain a period of time for making medicinal liquid can try one's best in intestinal, medicinal liquid once should more than 200ml more, can before sleeping night coloclysis, no longer out-of-bed activity after coloclysis, to improve curative effect.
Five, efficacy assessment standard
1, cure: clinical symptoms, sign disappear, and suffer from abdominal pain, transference cure of having loose bowels, stool is shaped, and fibro-colonoscope check is normal, and intestinal mucosa pathological changes recovers normal;
2, effective: clinical symptoms obviously alleviates, and sign disappears substantially, times of defecation reduces, and is substantially shaped, and fibro-colonoscope check takes a turn for the better, and intestinal mucosa pathological changes obviously changes;
3, invalid: before and after treatment, clinical symptoms and sign are without improvement, fibro-colonoscope check is without taking a turn for the better.
Six, observation group's result statistics
Matched group result is added up
Wherein: total effective rate=cure rate+improvement rate
Use the Comparison of therapeutic situation of this Chinese medicine preparation two groups of patients, two courses for the treatment of
Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness in treatment chronic colitis, effectively can improve the cure rate for the treatment of, alleviate the misery of patient, be worth promoting in clinical practice.
Model case and curative effect:
Case one, Wu, female, 25 years old, the abdominal part dull pain time of nearly one month, eat medicine several times and there is no an effect, and there is the phenomenon of constipation, complexion is wax yellow, lackluster, Wu goes to hospital to check, with mucus and pus and blood in stool examination, enteroscopy has ulcer to generate, hospital diagnosis is chronic colitis, after taking thing that hospital writes a prescription, transference cure, but recur after one week, made preparation in the rear use embodiment of the present invention two, and selected preparation method, carry out enema treatment, patient's stomachache after 2 days, abdominal distention disappears, constipation phenomenon is eased, continue a course for the treatment of of use, patient clinical symptom disappears completely, defecation is normal, complexion recovers ruddy gradually, nutriture is also deducted a percentage, hospital's microscopy intestinal mucosa is gone to recover normal, recovery from illness, follow up a case by regular visits to half a year, do not recur.
Case two, Chen, man, 49 years old, frequent diarrhoea, stomachache, rush down rear alleviation of pain, serious every day period, times of defecation was about 7-10 time, when getting up especially in the morning, with a small amount of mucus, remove examination in hospital, be diagnosed as chronic colitis, patient body is not good especially always, wish to adopt Chinese traditional treatment, went to a doctor in here afterwards, adopt made preparation in the embodiment of the present invention two, and selected preparation method, after using 1 course for the treatment of, patient defecates shaping, diarrhoea number of times reduces, the symptoms such as pain are clearly better, for consolidate curative effect, continue 1 course for the treatment of of use, stomachache, symptom of diarrhea takes a turn for the better completely, hospital is gone to check, intestinal mucosa recovers, follow up a case by regular visits to and do not recur half a year, recovery from illness.
Case three, Liu, man, 39 years old, in the nearly time more than a year every day get up after suddenly remove toilet stool 1-2 time, stagnant and not well, left lower quadrant minister have a dull ache, and appetite does not become recently, but whole people but becomes thin, complexion is ugly, remove examination in hospital, be diagnosed as chronic colitis, adopt various medicine, have little effect, and easily recur, went to a doctor in here afterwards, adopt made preparation in the embodiment of the present invention two, and selected preparation method, after using 1 course for the treatment of, patient defecates shaping, diarrhoea number of times reduces, the symptoms such as pain are clearly better, continue 1 course for the treatment of of use, stomachache, symptom of diarrhea takes a turn for the better completely, arriving of complexion improves, health is also recovered to some extent, hospital is gone to check, intestinal mucosa recovers, follow up a case by regular visits to and do not recur half a year, recovery from illness.
Claims (4)
1. the Chinese medicine composition for chronic colitis, it is characterized in that, this Chinese medicine composition is made up of the medicine of following weight portion: Radix Notoginseng powder 1-5 part, Flos Lonicerae 15-25 part, Radix Scutellariae 10-20 part, Fructus Forsythiae 13-23 part, Herba Pogostemonis 10-20 part, Rhizoma Atractylodis 10-20 part, Herba Eupatorii 7-17 part, Fructus Amomi 3-9 part, Semen Myristicae 3-9 part, Fructus Tsaoko 4-14 part, Semen Coicis 25-35 part, Rhizoma Alismatis 10-20 part, Semen Hoveniae (Fructus Hoveniae) 10-20 part, Radix Aconiti Lateralis Preparata 10-20 part, Rhizoma Zingiberis 13-23 part, Fructus Evodiae 3-9 part, Fructus Litseae 1-5 part, Pericarpium Citri Reticulatae Viride 7-17 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Radix Codonopsis 10-20 part, Radix Glycyrrhizae Preparata 4-14 part.
2. the Chinese medicine composition for chronic colitis according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Notoginseng powder 3 parts, Flos Lonicerae 20 parts, Radix Scutellariae 15 parts, Fructus Forsythiae 18 parts, Herba Pogostemonis 15 parts, Rhizoma Atractylodis 15 parts, Herba Eupatorii 12 parts, Fructus Amomi 6 parts, Semen Myristicae 6 parts, Fructus Tsaoko 9 parts, Semen Coicis 30 parts, Rhizoma Alismatis 15 parts, Semen Hoveniae (Fructus Hoveniae) 15 parts, Radix Aconiti Lateralis Preparata 15 parts, Rhizoma Zingiberis 18 parts, Fructus Evodiae 6 parts, Fructus Litseae 3 parts, 12 parts, Pericarpium Citri Reticulatae Viride, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Codonopsis 15 parts, Radix Glycyrrhizae Preparata 9 parts.
3. the Chinese medicine preparation for chronic colitis according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is enema.
4. the preparation method for the Chinese medicine preparation of chronic colitis, it is characterized in that, preparation method is as follows: step one: according to weight proportion of the present invention, Fructus Forsythiae, Fructus Amomi, Semen Myristicae, Fructus Tsaoko, Semen Coicis, Semen Hoveniae (Fructus Hoveniae), Fructus Evodiae, Fructus Litseae, Pericarpium Citri Reticulatae Viride are bound up with gauze, be put in water and soak about 45 minutes, filter, for subsequent use; Step 2: by weight proportion of the present invention, take Radix Scutellariae, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis put into marmite, add after soaking in step one and remain cold water, add water and exceed powder 2-4 centimetre, after being fried boiling with high heat, again with 30 minutes at a simmer, filter, obtain filtrate, the water of 3 cm is added in residue medicinal residues, continuation decoction about 20 minutes, then adds a kind of medicated bag of step and Herba Pogostemonis, Herba Eupatorii, Rhizoma Alismatis, Radix Glycyrrhizae Preparata continue decoction 30 minutes, finally adds Flos Lonicerae and decocts 10 minutes, filter, waste, merges twice filtrate, for subsequent use; Step 3: left standstill, get supernatant by gained medicinal liquid in step 2, concentrated, add Radix Notoginseng powder, stir, subpackage sterilizing obtains coloclysis medicament.
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| CN105106900A (en) * | 2015-09-22 | 2015-12-02 | 姜水清 | Chinese herbal preparation for treating small intestinal Crohn's disease |
| CN106256360A (en) * | 2016-05-15 | 2016-12-28 | 徐敏 | A kind of treat the Chinese medicine composition of ulcerative colitis, pharmaceutical preparation and application |
| CN106492103A (en) * | 2016-11-29 | 2017-03-15 | 陈先亚 | A kind of treat Chinese medicine composition of chronic diarrhea and preparation method thereof |
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| CN1346666A (en) * | 2001-09-30 | 2002-05-01 | 邹义达 | Chinese patent medicine for treating chronic colitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105106900A (en) * | 2015-09-22 | 2015-12-02 | 姜水清 | Chinese herbal preparation for treating small intestinal Crohn's disease |
| CN106256360A (en) * | 2016-05-15 | 2016-12-28 | 徐敏 | A kind of treat the Chinese medicine composition of ulcerative colitis, pharmaceutical preparation and application |
| CN106492103A (en) * | 2016-11-29 | 2017-03-15 | 陈先亚 | A kind of treat Chinese medicine composition of chronic diarrhea and preparation method thereof |
| CN106492103B (en) * | 2016-11-29 | 2019-09-06 | 陈先亚 | A kind of Chinese medicine composition and preparation method thereof for treating chronic diarrhea |
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