CN104721786A - Traditional Chinese medicine preparation for treating intrahepatic cholestasis of pregnancy and preparation method of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for treating intrahepatic cholestasis of pregnancy and preparation method of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating intrahepatic cholestasis of pregnancy. The treating intrahepatic cholestasis of pregnancy is prepared from the following raw materials: radix bupleuri, curcuma aromatic, white paeony root, christina loosestrife herb, herba artemisiae scopariae, pericarpium citri reticulatae, pericarpium citri reticulatae viride, pinellia ternate, scutellaria baicalensis honeysuckle, fructus forsythia, semen plantaginis, endothelium corneum gigeriae galli, dandelion, cooked rhubarb, szechwan chinaberry fruit, rhizoma corydalis, ligusticum wallichii, rhizoma cyperi, fructus aurantii, costustoot, radix isatidis, ginger, jujube and radix liquiritiae at a certain weight ratio. The traditional Chinese medicine preparation has the efficacies of soothing the liver, relieving depression, enriching blood, softening the liver, eliminating dampness and heat, eliminating dampness and relieving itching, and is capable of effectively treating intrahepatic cholestasis of pregnancy.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of intrahepatic cholestasis of pregnancy, the invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Intrahepatic cholestasis of pregnancy (ICP) is in gestation, late period distinctive complication, raise as feature with skin pruritus and bile acid clinically, main harm fetus, makes perinatal feruses M & M increase.This disease is the fetus sudden death being difficult to predict to the harm that gestation is maximum, and this risk is relevant to severity extent.Primary disease has recurrent, and this point of puerperium can rapidly disappear, and gestation or oral estrogen contraceptive can recur often again.ICP sickness rate 0.8% ~ 12.0%, has obvious region and race difference, domestic Shanghai and Sichuan Province's sickness rate higher.
Anemia of pregnant woman's body inner estrogen level significantly increases, and estrogen can make Na+-K+-ATP enzymatic activity decline, and energy provides minimizing, causes cholic acid dysbolismus; Estrogen can make C/PL ratio in liver plasma membrane rise, and mobility reduces, and affects the permeability to cholic acid, bile is flowed out and is obstructed; Estrogen action, in the estrogen receptor of surface of hepatocytes, changes the synthesis of Hepatocyte matter, and causing bile to reflux increases.Above-mentioned combined factors effect may cause the generation of ICP.Clinical research is thought, estrogen is not the only factor that ICP causes a disease, and may be that estrogen metabolism exception and liver cause the estrogen hypersensitivity that trimester of pregnancy physiological increases.Intrahepatic Cholestasis also with also has relation with E&H trimester of pregnancy in addition, and general winter is higher than summer.
Nearly all patient's onset symptoms is the pruritus occurring without skin injury pregnant late period, and about 80% patient occurred after 30 weeks, the even more morning had.Pruritus degree varies, often in persistence, daytime is light, and night aggravates.Pruritus is general first from palm and sole, then gradually to limbs proximal extension, even can develop into face, but seldom invade and mucosa.This pruritis on average about 3 weeks, also has and reaches several months person, alleviates rapidly, disappears within point a few hours in puerperium or a few days.Insomnia, fatigue, Nausea and vomiting, loss of appetite etc. are caused during serious pruritus.The visible scratch of limbs skin; 10% ~ 15% patient occurs to occur slight jaundice in a few days to several weeks in pruritus, and some cases jaundice and pruritus occur simultaneously, disappear within point a few days in puerperium.The hyperbilirubinemia performances such as companion's urine color intensification simultaneously.ICP anemia of pregnant woman is without acute and chronic hepatitis sign, and hepatomegaly but quality is soft, has light tenderness.
Due to etiology unknown, add that forepart pregnant women is more special period, clinically definite medicine be there is no for intrahepatic cholestasis of pregnancy at present, all the medicine of the clinical symptoms alleviating or alleviate anemia of pregnant woman mostly, and improve the medicine of perinatal feruses, the specific medicament of never generally acknowledging clinically.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of intrahepatic cholestasis of pregnancy, this Chinese medicine preparation has good effect for intrahepatic cholestasis of pregnancy, easy to use, cheap, the feature little to the injury of anemia of pregnant woman and fetus.
Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment intrahepatic cholestasis of pregnancy.
Inventor is in clinical treatment practice for many years, observe intrahepatic cholestasis of pregnancy and many harmful effects are brought for anemia of pregnant woman and fetus, inventor is according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of intrahepatic cholestasis of pregnancy repeatedly, the present invention selects Radix Bupleuri, Radix Curcumae, the Radix Paeoniae Alba, Herba Lysimachiae, Herba Artemisiae Scopariae, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, the Rhizoma Pinelliae, Radix Scutellariae, Flos Lonicerae, Fructus Forsythiae, Semen Plantaginis, Endothelium Corneum Gigeriae Galli, Herba Taraxaci, Radix Et Rhizoma Rhei, Fructus Toosendan, Rhizoma Corydalis, Rhizoma Chuanxiong, Rhizoma Cyperi, Fructus Aurantii, the Radix Aucklandiae, Radix Isatidis, Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Glycyrrhizae Preparata combines, by these drug regimens, each efficacy of drugs is made to produce synergism, make it that there is dispersing the stagnated live-QI to relieve the stagnation of QI, to enrich blood easing the affected liver, eliminating damp-heat, effect that removing dampness is antipruritic, thus can intrahepatic cholestasis of pregnancy be treated.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Bupleuri: be Umbelliferae herbaceos perennial Radix Bupleuri Bupleurum chinense DC.(Radix Bupleuri) or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd.(Radix Bupleuri Scorzonerifolii) root or herb.Nature and flavor: bitter, pungent, be slightly cold.Return liver, gallbladder meridian.Effect: reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang.Modern pharmacological research proves: " medicineization justice ": Radix Bupleuri, and property is gently clear, and main liter falls apart, mildly bitter flavor, main soothing the liver." book on Chinese herbal medicine through separate ": " Radix Bupleuri, stagnation of QI person in its main trusted subordinate's the intestines and stomach, trusted subordinate's the intestines and stomach, five hide six mansions also, and Zang Fu totally ten two warps; all 11 hide and all depend on gallbladder, and Radix Bupleuri is gently clear, and rise and reach courage, courage bar reaches; then 11 hide from Xuanhua, therefore in trusted subordinate's the intestines and stomach, all have stagnation of QI, all can fall apart also.Its main diet accumulator, lid diet enters stomach, the spleen transporting essential substances to the liver, the evacuation of liver, borrow again few positive gallbladder be the master of hair growth promoting also, Radix Bupleuri liter reaches courage, then liver can fall apart essence, and diet gathers from lower.Shaoyang channel row half exterior and half interior, few sun, by evil, evilly also then to be trembled with fear in the moon, evil and in Yang Zere, Radix Bupleuri treating SHAO YANG disease by mediation, therefore the pathogen of main cold and heat also." Radix Bupleuri has the effect of good dispersing the stagnated live-QI to relieve the stagnation of QI, is the key medicine for the treatment of irritability stasis, no matter interior by stagnation of liver-QI, outward by hindering servant person to the pain over the hypochondriac region.
Radix Curcumae: be the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor: pungent, bitter, cold.Return liver, the heart, lung meridian.Effect: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, removing heat from blood removing blood stasis with potent drugs.Cure mainly: all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.The pungent loose hardship of this product is let out, heat clearing away cold in nature, can have one's ideas straightened out by heart fire-clearing upset-relieving.
The Radix Paeoniae Alba: be the dry root of dicotyledon ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: cool, picric acid, is slightly cold.Effect: easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receives antiperspirant.This product energy nourishing the liver blood, holding back liver-yin, subduing the hyperfunction of the liver sun, dispersing liver-energy, can delay again that contraction is anxious, relieve the pain pain, is the good medicine of the various pain for the treatment of Liver Channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " purgation of spleen excess heat, only abdomen pain, sealing rushes down, and receives adverse flow of liver-QI pain, takes good care of conscience spleen channel blood, relax through sending down the abnormal ascending QI, only irritability pain." " herbal classic " Radix Paeoniae, though respectively in vain not red, the two is master to some extent respectively.So seek and unravel silk it and cure mainly all diseases, one is that replenishing blood and nourishing liver spleen is Kidney-Yin, and receives and take the photograph the at random of temper, and throwing off restraint of irritability is horizontal, then the Radix Paeoniae Alba.
Herba Lysimachiae: be the dry herb of Ofthe Primulaceae Lysimachia christinae Hance Lysimachia christinae Hance.Nature and flavor: sweet, salty, are slightly cold.Return liver, gallbladder, kidney, urinary bladder channel.Effect: eliminating damp-heat, treating stranguria, detumescence.For pyretic stranguria, Sha Lin, urinates and puckeryly to have a pain, jaundice dark coloured urine, carbuncle furuncle, venom; Liver and bile stone, lithangiuria.For jaundice due to damp-heat, can with Herba Artemisiae Scopariae, Fructus Gardeniae with using.
Herba Artemisiae Scopariae: be the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparia Waldst. et Kit. or Herba Artemisiae Scopariae Artemisia capillaris Thunb..Nature and flavor: bitter, pungent, are slightly cold.Return spleen, stomach, liver, gallbladder meridian.Effect: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis.The disease of jaundice is there is for damp and hot fumigating, can be simply alone, it is for oral administration that heavy dose decocts soup; The effect of this product jaundice eliminating subcutaneous ulcer is excellent, therefore except for except jaundice due to damp-heat, for the YIN jaundice disease because occurring by cold-damp or innate deficiency of YANG in the body, also can apply.
Pericarpium Citri Reticulatae: be the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor: temperature are pungent, bitter.Enter spleen, stomach, lung meridian.Effect: regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.This product temperature can circulation of qi promoting, pungently can disperse, bitter and sluice.Pericarpium Citri Reticulatae and the same use of Fructus Aurantii Immaturus, acrid in the mouth circulation of qi promoting, fragrance enters spleen, therefore can promoting the circulation of QI to relieve pain, spleen invigorating and in, Pericarpium Citri Reticulatae and the Rhizoma Pinelliae can drying dampness to eliminate phlegm with use, again can warming for resolving cold-phlegm.
Pericarpium Citri Reticulatae Viride: be rutaceae orange Citrus reticulata Blanco and the dry young fruit of variety thereof or the peel of immature fruit.Nature and flavor: bitter, pungent, warm.Enter liver, gallbladder, stomach warp.Effect: soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.For costa sternales gastral cavity distending pain, acute mastitis, colic, stagnation of QI due to dyspepsia.Compendium of Material Medica: blue or green Pericarpium Citri tangerinae, the blue or green gas of its color is strong, bitter in the mouth and pungent, control with vinegar, so-called liver for loose, anxious food pungent with loose it, let out it with acid, with hardship fall also.Pericarpium Citri Reticulatae is floating and rise, and entering spleen lung qi divides, and Pericarpium Citri Reticulatae Viride is heavy and fall, and enters liver and gall edema caused by disorder of QI, and one dual-purpose, physics naturally also.Children's's removing food stagnancy, multiplex Pericarpium Citri Reticulatae Viride, can diaphoresis, and person is unavailable antiperspirant.
The Rhizoma Pinelliae: be the tuber at the Rhizoma Arisaematis section plant Rhizoma Pinelliae (Pinellia ternata (Thunb.) Breit.).Nature and flavor: pungent, temperature, poisonous.Enter spleen, stomach warp.Effect: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.The pungent loose warm-dryness syndrome of these product is poisonous, main enter taste double enter lung, water of manageing it wets, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.Water is wet to be gone, and the strong and sputum of spleen is from disappearing, and inverse gas falls then harmonization of the stomach and feeling of fullness vomiting from only, therefore is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.Both cure mainly the abundant expectoration cough with asthma QI rising in reverse order of spleen damp-phlegm heap soil or fertilizer over and around the roots, control again the dizzy palpitation and insomnia that damp-phlegm is violated." property of medicine opinion ": expectorant saliva, appetite promoting and the spleen strengthening, anti-nausea, go expectorant in the heart full, lower lung qi, master coughs knot.New survivor rub be coated with carbuncle do not disappear.
Radix Scutellariae: be the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Nature and flavor: bitter, cold.Return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.The clinical practice of Radix Scutellariae is antibacterial relatively good, and does not develop immunity to drugs.This product has the merit of clearing away heat and cooling blood hemostasis, intimately flourishing with controlling, and the haematemesis of the absurd row of forcing blood, metrorrhagia, has blood in stool.
Flos Lonicerae: the flower that dry flower or band for caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera dasystyla Rehd. are just opened.Nature and flavor: sweet, cold.Return lung, the heart, stomach warp.Effect: heat-clearing and toxic substances removing, wind-dispelling heat-dissipating.This product is sweet in flavor and cold in property, can heat-clearing and toxic substances removing, again kind loose carbuncle detumescence, for treating the key medicine of all YANG syndrome carbuncle furuncle.
Fructus Forsythiae: be the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.Nature and flavor: bitter, are slightly cold.Return lung, the heart, small intestine meridian.Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.Fructus Forsythiae is normal with the same use of Flos Lonicerae, Fructus Forsythiae bitter in the mouth cool in nature, gently clearly to float, and can control all heat of the part of the body cavity above the diaphragm housing the heart and lungs, outstanding energy removing toxicity for eliminating carbuncles and eliminating stagnation, therefore is the key medicine of persons particularly liable to develop skin infection.Fructus Forsythiae has broad-spectrum antibacterial action, has very strong inhibitory action to staphylococcus aureus, Hayes dysentery bacterium, has certain inhibitory action to other pathogenic bacterium, influenza virus, fungus.There is antiinflammatory action.Antibacterial action: Fructus Forsythiae concentrated decotion has antibacterial action in vitro, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.Fructus Forsythiae antimicrobial spectrum is very wide, has obvious antiinflammatory action, can promote the formation of inflammatory barrier, reduces capillary permeability, reduces inflammatory exudation.
Semen Plantaginis: be the dry mature seed of Plantaginaceae plant Herba Plantaginis Plantago asiatica L. or Plantago depressa Willd Plantago depressa Willd..Nature and flavor: sweet, are slightly cold.Return liver, kidney, lung, small intestine meridian.Effect: clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.
Endothelium Corneum Gigeriae Galli: be the dry inner wall of sandbag of Phasianidae animal man chicken Gallus gallus domesticus Brisson.Nature and flavor: sweet are flat.Return spleen, stomach, small intestinal, urinary bladder channel.Effect: invigorating the stomach and promoting digestion, arresting seminal emission.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission." Bencao Jingshu ": gizzard is the spleen of chicken is the institute of digesting and absorbing the essence of foodstuff of disappearing.The sensible large intestine of its gas, bladder two warp.There is heat then to let out dysentery incontinence of urine, the gas that must be slightly cold then evanescence of heat, and let out the spontaneous recovery of dysentery incontinence of urine.Tired give birth to because of heat, heat is gone therefore tired of stopping also.This life controls all chancre multiple-effect with it again.
Herba Taraxaci: Herba Taraxaci, also known as bed-wetting grass, is feverfew Herba Taraxaci Toraxacum mongolicum Hand. Mazz., alkali ground Herba Taraxaci Toraxacum borealisinense Kitam. or the dry herb belonging to several plants together.Nature and flavor: sweet, micro-hardship, cold.Return liver, stomach warp.Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Herba Taraxaci has effect of antiinflammatory, antibacterial, antitumor, heat-clearing and toxic substances removing, and applied range on modern clinic, makes good use of.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Acute mastitis caused by pyretic toxicity is swollen and ache, furuncle has good effect, juice can be decocted separately and take orally, or external application local; Also the same use of other heat and toxic materials clearing away medicine can be coordinated, as Flos Lonicerae, Fructus Forsythiae, Herba Violae, Flos Chrysanthemi Indici, Radix Paeoniae Rubra etc.
Radix Et Rhizoma Rhei: be polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim ex Balf.Or Rheum officinale Rheum officinale Baill.The processed goods of dry root and rhizome.Nature and flavor: bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Effect: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.Radix Et Rhizoma Rhei has anti-infectious function, all has inhibitory action to multiple Gram-positive and negative bacterium.
Fructus Toosendan: be the dry mature fruit of Meliaceae plant Fructus Toosendan Melia toosendan Sieb. et Zucc..Nature and flavor: bitter, cold; Slightly poisonous.Return liver, small intestinal, urinary bladder channel.Effect: soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.
Rhizoma Corydalis: be the dry tuber of papaveraceae plant corydalis Corydalis yanhusuo W. T. Wang.Nature and flavor: acrid, bitter, warm.Return liver, spleen channel.Effect: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.The pungent loose temperature of this product is led to, the stagnation of QI in energy promoting the circulation of blood, stasis in gas, blood-activating and qi-promoting pain relieving, and the kind multiple pain controlled caused by stagnation of QI and blood, its analgesic effect is excellent.Record in " book on Chinese herbal medicine is looked for the truth ": Rhizoma Corydalis, no matter being blood is gas, amass and loose person, taking this power can be sensible, warm in nature with it, then can manage it in QI and blood can be smooth, and acrid in the mouth then can moisten can fall apart in QI and blood, so manage upper and lower all pains all over the body, merit of often walking alone is many.
Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Nature and flavor: pungent, temperature.Return liver, gallbladder, heart channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.The pungent loose temperature of this product is led to, can top, up mountain peak, assigns the sea of blood, outer thorough fur, bypass extremity, can invigorate blood circulation and can circulation of qi promoting, and it is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.Rhizoma Chuanxiong has obvious sedation.The in vitro testses such as antibacterial action: Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.Rhizoma Chuanxiong water logging agent (1:3) also has inhibitory action to some pathogenic dermatophytes in vitro.
Rhizoma Cyperi: be the dry rhizome of sedge dried tuber Cyperus rotundus L..Nature and flavor: pungent, micro-hardship, micro-sweet are flat.Return liver, spleen, tri-jiao channel.Effect: promoting QI circulation for relieving depression, menstruction regulating and pain relieving, antiabortive, regulate the flow of vital energy Shu Yu, harmonizing the liver and stomach.The pungent loose hardship of this product is let out, and is the key medicine of depressed liver-energy dispersing and QI regulating, can be used for all pain cards caused by irritability stasis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": adjust the gas in blood, dissipating depression of QI, alleviating distention in middle-JIAO, helps digestion." book on Chinese herbal medicine is looked for the truth ": Rhizoma Cyperi, exclusive dissipating depression of QI falls apart gas, and with Radix Aucklandiae circulation of qi promoting, looks are with real different, and Radix Aucklandiae abnormal smells from the patient hardship is bad, therefore ventilation is very prompt, and this is then bitter and not very, therefore resolving depression is in the majority, and property and in the Radix Aucklandiae, therefore can add and subtract discrepancy, thinks circulation of qi promoting obstruction-removing prescription, otherwise should this and those ears unsuitable.
Fructus Aurantii: be the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof.Nature and flavor: bitter, pungent, sour, temperature.Return spleen, stomach warp.Effect: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus." Bencao Jingshu ": Fructus Aurantii, abnormal smells from the patient led, generally identical with Fructus Aurantii Immaturus.But Fructus Aurantii Immaturus shape is little, its gas is complete, and its property is strong, therefore is apt to assign; Fructus Aurantii shape is large, and its gas falls apart, and its property is delayed, and Gu Qihang is slightly slow, is dividing and entering large intestine also with able person's chest and diaphragm lung stomach.Its main air is itched paralysis, easing joint movement, only wind pain person, lid lung governing skin and hair, the main muscle of stomach, wind and cold wets in two warps, then skin pruritus, or has a pain, or numb, and this medicine has hardship to let out pungent loose merit, doublely can draw all wind medicines and enter two dirty, therefore for controlling needed for wind, ailment said due to cold or exposure was both fallen apart, then save nature tonneau.It treats consumptive disease cough, back of the body arm bored and listless person, and lid also refers to that wind and cold is strongly fragrant in the part of the body cavity above the diaphragm housing the heart and lungs, then lung qi is stagnant and be bored and listless cough.
The Radix Aucklandiae: be the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne..Nature and flavor: pungent, bitter, temperature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.Effect: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.The pungent row of this product, hardship are let out, Wen Tong, benefaction stagnation of QI in spleen and stomach, are promoting the circulation of QI to relieve pain key medicine, and Radix Aucklandiae gas falls apart, and can control stagnation of QI due to dyspepsia.The pharmaceutical research Radix Aucklandiae has facilitating digestion liquid to secrete to gastrointestinal tract, and suppresses the effect of various bacteria and fungus.
Radix Isatidis: be the dry root of cruciferae isatis Isatis indigotica Fort..Nature and flavor: bitter, cold.Return liver, stomach warp.Effect: heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Radix Isatidis is more good at resolving toxin and disinhibiting the throat eliminating stagnation, is mainly used in maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis etc.
Rhizoma Zingiberis Recens: be the fresh rhizome of zingiber Zingiber officinale Rosc..Nature and flavor: pungent, tepor.Return lung, spleen, stomach warp.Effect: relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough, solving toxin of fish and crab, separates poison of drug.Especially for fish Eriocheir sinensis poison, the drug intoxication such as the Rhizoma Pinelliae, Rhizoma Arisaematis has Detoxication.Rhizoma Zingiberis Recens can act on sympathetic nerve and vagal system, and have the effect suppressing stomach function and direct excited pipe smooth muscle, Rhizoma Zingiberis Recens has inhibitory action to central nervous system.
Fructus Jujubae: be the dry mature fruit of Rhamnaceae jujube Fructus Jujubae Ziziphus jujuba Mill. var. inermis (Bunge) Rehd..Nature and flavor: sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria." herbal classic ": main trusted subordinate's pathogen, regulating the spleen and stomach supports spleen, helps 12 warps.Flat gastric qi, logical nine orifices, mends weak breath, few body fluid, not enough, frightened in body, heaviness of limbs, and hundred medicines." book on Chinese herbal medicine is new again ": invigorating the spleen and replenishing QI, nourishing kidney warming the stomach, controls the deficiency of YIN.
Radix Glycyrrhizae Preparata: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Radix Glycyrrhizae Preparata is that processed goods smoked by the honey of Radix Glycyrrhizae.Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.
Side's solution of the present invention is: Radix Bupleuri reducing fever by reconciliation in side, dispersing the stagnated live-QI to relieve the stagnation of QI, Radix Curcumae regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, the Radix Paeoniae Alba is enriched blood easing the affected liver, suppressing the hyperactive liver pain relieving, Herba Lysimachiae eliminating damp-heat, Herba Artemisiae Scopariae clearing away damp-heat, jaundice eliminating subcutaneous ulcer, the above five tastes are monarch drug altogether, patient's cholestasis, bile acid raises, cause liver damage, therefore monarch drug fundamentally carries out dispersing the stagnated live-QI to relieve the stagnation of QI in disease, to enrich blood easing the affected liver, because the symptom that patient is the most basic is exactly pruritus, monarch drug also has eliminating damp-heat, the effect that removing dampness is antipruritic, the symptom of reduction of patient limbs pruritus, thus reach the effect of disease therapy.Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride regulating qi-flowing for strengthening spleen, soothing the liver dispelling the stagnated QI, Rhizoma Pinelliae drying dampness to eliminate phlegm, Radix Scutellariae heat clearing and damp drying, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci heat-clearing and toxic substances removing, wind-dispelling heat-dissipating, Semen Plantaginis clearing away heat and promoting diuresis, above eight tastes are ministerial drug altogether, and front four tastes increase the effect of monarch drug dispersing the stagnated live-QI to relieve the stagnation of QI, eliminating damp-heat, and rear a few taste has the effect of heat-clearing and toxic substances removing, also has the effect of broad-spectrum antiseptic simultaneously, three tastes are same use together, is more the increase in antibacterial scope and effect, can the symptom of pruritus brought because of cholestasis of reduction of patient.Endothelium Corneum Gigeriae Galli invigorating the stomach and promoting digestion, Radix Et Rhizoma Rhei removing pathogenic heat from blood and toxic substance from the body, Fructus Toosendan dispersing the stagnated live-QI to relieve the stagnation of QI, Rhizoma Corydalis regulating QI to relieve pain, Rhizoma Chuanxiong blood-activating and qi-promoting, Rhizoma Cyperi promoting QI circulation for relieving depression, Fructus Aurantii regulating the flow of QI to ease the stomach, Radix Aucklandiae promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion, Radix Isatidis heat-clearing and toxic substances removing, Rhizoma Zingiberis Recens warming middle-JIAO to arrest vomiting, and can separate the poison of the Rhizoma Pinelliae, Fructus Jujubae invigorating the spleen and replenishing QI, above a few taste is adjuvant drug altogether, while assisting a ruler in governing a country monarch drug, Rhizoma Zingiberis Recens detoxifies, and reduces the harmful effect of medicine to anemia of pregnant woman and fetus, Fructus Jujubae invigorating the spleen and replenishing QI, strengthen anemia of pregnant woman's body constitution, thus accelerate the improvement of the state of an illness.Radix Glycyrrhizae Preparata priming return through, coordinating the actions of various ingredients in a prescription, for making medicine.All medicine compatibilities in side, the monarch and his subjects pull together, help and make auxiliary altogether, make it to have dispersing the stagnated live-QI to relieve the stagnation of QI, effect that easing the affected liver of enriching blood, eliminating damp-heat, removing dampness are antipruritic, effectively can treat intrahepatic cholestasis of pregnancy.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Bupleuri 10-20 part, Radix Curcumae 7-17 part, Radix Paeoniae Alba 10-20 part, Herba Lysimachiae 15-25 part, Herba Artemisiae Scopariae 13-23 part, Pericarpium Citri Reticulatae 7-17 part, Pericarpium Citri Reticulatae Viride 7-17 part, Rhizoma Pinelliae 4-14 part, Radix Scutellariae 10-20 part, Flos Lonicerae 10-20 part, Fructus Forsythiae 7-17 part, Semen Plantaginis 10-20 part, Endothelium Corneum Gigeriae Galli 7-17 part, Herba Taraxaci 10-20 part, Radix Et Rhizoma Rhei 4-14 part, Fructus Toosendan 7-17 part, Rhizoma Corydalis 10-20 part, Rhizoma Chuanxiong 7-17 part, Rhizoma Cyperi 7-17 part, Fructus Aurantii 5-15 part, Radix Aucklandiae 4-14 part, Radix Isatidis 10-20 part, Rhizoma Zingiberis Recens 5-15 part, Fructus Jujubae 5-15 part, Radix Glycyrrhizae Preparata 3-9 part.
Wherein be preferably: Radix Bupleuri 15 parts, Radix Curcumae 12 parts, the Radix Paeoniae Alba 15 parts, Herba Lysimachiae 20 parts, Herba Artemisiae Scopariae 18 parts, Pericarpium Citri Reticulatae 12 parts, 12 parts, Pericarpium Citri Reticulatae Viride, the Rhizoma Pinelliae 9 parts, Radix Scutellariae 15 parts, Flos Lonicerae 15 parts, Fructus Forsythiae 12 parts, Semen Plantaginis 15 parts, Endothelium Corneum Gigeriae Galli 12 parts, Herba Taraxaci 15 parts, Radix Et Rhizoma Rhei 9 parts, Fructus Toosendan 12 parts, Rhizoma Corydalis 15 parts, Rhizoma Chuanxiong 12 parts, Rhizoma Cyperi 12 parts, Fructus Aurantii 10 parts, the Radix Aucklandiae 9 parts, Radix Isatidis 15 parts, 10 parts, Rhizoma Zingiberis Recens, 10 parts, Fructus Jujubae, Radix Glycyrrhizae Preparata 6 parts.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug pulverize mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.
The preferred preparation method of the present invention is decoction, and its preparation method is as follows:
Step one: by weight proportion of the present invention, first becomes medicated bag by Fructus Forsythiae, Semen Plantaginis, Fructus Toosendan, Fructus Aurantii, Fructus Jujubae bundle, is put in water and soaks 40-50 minute, filters, for subsequent use;
Step 2: by weight proportion of the present invention, take Radix Curcumae, the Radix Paeoniae Alba, Radix Scutellariae, Radix Et Rhizoma Rhei, Rhizoma Chuanxiong, Rhizoma Cyperi, the Radix Aucklandiae, Radix Isatidis, marmite put into by Rhizoma Zingiberis Recens, add after soaking in step one and remain cold water, exceed the horizontal finger of powder 3-4, after being fried boiling with high heat, again with 30 minutes at a simmer, filter to get filtrate, the horizontal finger water of 2-3 is added in residue medicinal residues, then Radix Bupleuri is added, Herba Lysimachiae, Herba Artemisiae Scopariae, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, the Rhizoma Pinelliae, Endothelium Corneum Gigeriae Galli, Herba Taraxaci, medicated bag in Rhizoma Corydalis and step one continues to decoct 20-30 minute, finally add Flos Lonicerae and Radix Glycyrrhizae Preparata decocts 10 minutes, filter, waste, obtain filtrate, merge twice filtrate, both the decoction for the treatment of gestational intrahepatic cholestasis of pregnancy of the present invention.
Effect that medicine of the present invention has dispersing the stagnated live-QI to relieve the stagnation of QI, easing the affected liver of enriching blood, eliminating damp-heat, removing dampness are antipruritic, and good effect, easy to use, cheap, little to the injury of anemia of pregnant woman and fetus, according to clinical 196 routine patient view statistics, to use after a course for the treatment of of medicine of the present invention total effective rate 96% after 89.8%, two courses for the treatment of of total effective rate.
Detailed description of the invention
Embodiment one, Radix Bupleuri 10 parts, Radix Curcumae 7 parts, the Radix Paeoniae Alba 10 parts, Herba Lysimachiae 15 parts, Herba Artemisiae Scopariae 13 parts, Pericarpium Citri Reticulatae 7 parts, 7 parts, Pericarpium Citri Reticulatae Viride, the Rhizoma Pinelliae 4 parts, Radix Scutellariae 10 parts, Flos Lonicerae 10 parts, Fructus Forsythiae 7 parts, Semen Plantaginis 10 parts, Endothelium Corneum Gigeriae Galli 7 parts, Herba Taraxaci 10 parts, Radix Et Rhizoma Rhei 4 parts, Fructus Toosendan 7 parts, Rhizoma Corydalis 10 parts, Rhizoma Chuanxiong 7 parts, Rhizoma Cyperi 7 parts, Fructus Aurantii 5 parts, the Radix Aucklandiae 4 parts, Radix Isatidis 10 parts, 5 parts, Rhizoma Zingiberis Recens, 5 parts, Fructus Jujubae, Radix Glycyrrhizae Preparata 3 parts.
Embodiment two, Radix Bupleuri 15 parts, Radix Curcumae 12 parts, the Radix Paeoniae Alba 15 parts, Herba Lysimachiae 20 parts, Herba Artemisiae Scopariae 18 parts, Pericarpium Citri Reticulatae 12 parts, 12 parts, Pericarpium Citri Reticulatae Viride, the Rhizoma Pinelliae 9 parts, Radix Scutellariae 15 parts, Flos Lonicerae 15 parts, Fructus Forsythiae 12 parts, Semen Plantaginis 15 parts, Endothelium Corneum Gigeriae Galli 12 parts, Herba Taraxaci 15 parts, Radix Et Rhizoma Rhei 9 parts, Fructus Toosendan 12 parts, Rhizoma Corydalis 15 parts, Rhizoma Chuanxiong 12 parts, Rhizoma Cyperi 12 parts, Fructus Aurantii 10 parts, the Radix Aucklandiae 9 parts, Radix Isatidis 15 parts, 10 parts, Rhizoma Zingiberis Recens, 10 parts, Fructus Jujubae, Radix Glycyrrhizae Preparata 6 parts.
Embodiment three, Radix Bupleuri 20 parts, Radix Curcumae 17 parts, white 20 parts, Herba Lysimachiae 25 parts, Herba Artemisiae Scopariae 23 parts, Pericarpium Citri Reticulatae 17 parts, 17 parts, Pericarpium Citri Reticulatae Viride, the Rhizoma Pinelliae 14 parts, Radix Scutellariae 20 parts, Flos Lonicerae 20 parts, Fructus Forsythiae 17 parts, Semen Plantaginis 20 parts, Endothelium Corneum Gigeriae Galli 17 parts, Herba Taraxaci 20 parts, Radix Et Rhizoma Rhei 14 parts, Fructus Toosendan 17 parts, Rhizoma Corydalis 20 parts, Rhizoma Chuanxiong 17 parts, Rhizoma Cyperi 17 parts, Fructus Aurantii 15 parts, the Radix Aucklandiae 14 parts, Radix Isatidis 20 parts, 15 parts, Rhizoma Zingiberis Recens, 15 parts, Fructus Jujubae, Radix Glycyrrhizae Preparata 9 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Accept patient's totally 196 examples of outpatient service intrahepatic cholestasis of pregnancy for medical treatment, 26 years old patient's mean age, in pregnant all 25-37 weeks, age, pregnant week etc., every data was substantially identical, no significant difference (P > 0.05).
Two, diagnostic criteria:
Diagnostic criteria adopts the diagnostic criteria of " Chinese obstetrics and gynecology " intrahepatic cholestasis of pregnancy in 1999:
1, there is skin pruritus symptom in trimester of pregnancy.
2, TOTAL BILE ACID TBA (TBA) level, glycocholic acid level significantly increase and are up to normal 100 times.
3, abnormal liver function, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT slightly raise.
4, can with slight jaundice, serum bilirubin is about 2.0 ~ 19 μm of ol/L.
5, ordinary circumstance is good, nothing obviously vomiting, inappetence etc.
6, divide puerperium pruritus, jaundice disappears, liver function recovers rapidly normal.
Three, Therapeutic Method:
According to Medications Example two of the present invention, and decoction prepared by preferred preparation method, taking a daily dose, decocting, take at twice, sooner or later respectively once, 5 days is a course for the treatment of.
Four, efficacy assessment standard:
1, cure: pruritus disappears, serum tolal bile acid (TBA) <10 μm of ol/L;
2, take a turn for the better: pruritus disappears or obviously alleviates, serum tolal bile acid (TBA) reduces by more than 1/2 than initial value;
3, do not heal: pruritis is without improvement, and serum tolal bile acid (TBA) reduces not obvious.
Five, therapeutic outcome statistics
Find that Chinese medicine of the present invention has good clinical effectiveness at treatment intrahepatic cholestasis of pregnancy by statistical data, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.
Model case and curative effect:
Case one, Song, female, 26 years old, normal pregnancy the 34th week, carry out product inspection all are normal before, recent appearance is felt sick, vomiting continues the time of one week, there is the phenomenon of slight xanthochromia in whole body, and have one day with whole body pruritus, without other symptoms, patient removes examination in hospital, be diagnosed as intrahepatic cholestasis in pregnancy, patient adopts the embodiment of the present invention two Chinese medicine preparation weight ratio, after patient takes a course for the treatment of, pruritis is significantly taken a turn for the better, hospital is gone to check, serum tolal bile acid content declines, patient continues the time of taking two days, body index is completely normal, after 2 months, fetus is born smoothly, patient fully recovers.
Case two, Liu, female, 25 years old, conceived 30 weeks of patient, all are normal in pregnant inspection in early stage, and hand pruritus appears suddenly in patient, sometimes with feeling sick, patient removes examination in hospital, be diagnosed as intrahepatic cholestasis in pregnancy, patient adopts the embodiment of the present invention two Chinese medicine preparation weight ratio, and after patient takes a course for the treatment of, pruritis is significantly taken a turn for the better, patient continues the time of taking a course for the treatment of, body index is completely normal, and serum tolal bile acid content recovers normal, and all are normal for fetus, smooth birth, patient fully recovers.
Claims (4)
1. treat the Chinese medicine preparation of intrahepatic cholestasis of pregnancy for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Bupleuri 10-20 part, Radix Curcumae 7-17 part, Radix Paeoniae Alba 10-20 part, Herba Lysimachiae 15-25 part, Herba Artemisiae Scopariae 13-23 part, Pericarpium Citri Reticulatae 7-17 part, Pericarpium Citri Reticulatae Viride 7-17 part, Rhizoma Pinelliae 4-14 part, Radix Scutellariae 10-20 part, Flos Lonicerae 10-20 part, Fructus Forsythiae 7-17 part, Semen Plantaginis 10-20 part, Endothelium Corneum Gigeriae Galli 7-17 part, Herba Taraxaci 10-20 part, Radix Et Rhizoma Rhei 4-14 part, Fructus Toosendan 7-17 part, Rhizoma Corydalis 10-20 part, Rhizoma Chuanxiong 7-17 part, Rhizoma Cyperi 7-17 part, Fructus Aurantii 5-15 part, Radix Aucklandiae 4-14 part, Radix Isatidis 10-20 part, Rhizoma Zingiberis Recens 5-15 part, Fructus Jujubae 5-15 part, Radix Glycyrrhizae Preparata 3-9 part.
2. the Chinese medicine preparation for the treatment of intrahepatic cholestasis of pregnancy according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Bupleuri 15 parts, Radix Curcumae 12 parts, the Radix Paeoniae Alba 15 parts, Herba Lysimachiae 20 parts, Herba Artemisiae Scopariae 18 parts, Pericarpium Citri Reticulatae 12 parts, 12 parts, Pericarpium Citri Reticulatae Viride, the Rhizoma Pinelliae 9 parts, Radix Scutellariae 15 parts, Flos Lonicerae 15 parts, Fructus Forsythiae 12 parts, Semen Plantaginis 15 parts, Endothelium Corneum Gigeriae Galli 12 parts, Herba Taraxaci 15 parts, Radix Et Rhizoma Rhei 9 parts, Fructus Toosendan 12 parts, Rhizoma Corydalis 15 parts, Rhizoma Chuanxiong 12 parts, Rhizoma Cyperi 12 parts, Fructus Aurantii 10 parts, the Radix Aucklandiae 9 parts, Radix Isatidis 15 parts, 10 parts, Rhizoma Zingiberis Recens, 10 parts, Fructus Jujubae, Radix Glycyrrhizae Preparata 6 parts.
3. the Chinese medicine preparation for the treatment of intrahepatic cholestasis of pregnancy according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.
4. the Chinese medicine preparation for the treatment of intrahepatic cholestasis of pregnancy according to claim 3, its preparation method is as follows: step one: by weight proportion of the present invention, first Fructus Forsythiae, Semen Plantaginis, Fructus Toosendan, Fructus Aurantii, Fructus Jujubae bundle is become medicated bag, is put in water and soaks 40-50 minute, filter, for subsequent use, step 2: by weight proportion of the present invention, take Radix Curcumae, the Radix Paeoniae Alba, Radix Scutellariae, Radix Et Rhizoma Rhei, Rhizoma Chuanxiong, Rhizoma Cyperi, the Radix Aucklandiae, Radix Isatidis, marmite put into by Rhizoma Zingiberis Recens, add after soaking in step one and remain cold water, exceed the horizontal finger of powder 3-4, after being fried boiling with high heat, again with 30 minutes at a simmer, filter to get filtrate, the horizontal finger water of 2-3 is added in residue medicinal residues, then Radix Bupleuri is added, Herba Lysimachiae, Herba Artemisiae Scopariae, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, the Rhizoma Pinelliae, Endothelium Corneum Gigeriae Galli, Herba Taraxaci, medicated bag in Rhizoma Corydalis and step one continues to decoct 20-30 minute, finally add Flos Lonicerae and Radix Glycyrrhizae Preparata decocts 10 minutes, filter, waste, obtain filtrate, merge twice filtrate, both the decoction for the treatment of gestational intrahepatic cholestasis of pregnancy of the present invention.
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| CN106361766A (en) * | 2016-11-01 | 2017-02-01 | 侯建生 | Application of ozonized oil in prevention and treatment of pregnancy diseases |
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| CN102698196A (en) * | 2012-06-08 | 2012-10-03 | 张春敏 | Decoction for treating cholestasis of pregnancy |
| CN104338078A (en) * | 2014-10-25 | 2015-02-11 | 赵玉洁 | Pharmaceutical composition for treating intrahepatic cholestasis in gestation period |
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