CN104906430A - Traditional Chinese medicine preparation for treating xerophthalmia and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating xerophthalmia. The traditional Chinese medicine preparation is prepared from barbary wolfberry fruit, white peony root, white mulberry root-bark, root-bark of Chinese wolfberry, bitter apricot seed, common lophatherum herb, tangerine peel, pinellia tuber, oriental waterplantain rhizome, Chinese gentian, dwarf lilyturf tuber, tree peony bark, figwort root, baical skullcap root, tuckahoe, ricepaperplant pith, chrysanthemum, cicada slough, dark plum fruit, inula flower, stem of noble dendrobium, fragrant solomonseal rhizome, divaricate saposhnikovia root, fineleaf schizonepeta herb and licorice root according to certain weight ratios. The traditional Chinese medicine preparation has the effects of nourishing the liver and kidneys, replenishing vital essence to improve eyesight, clearing heat and drying dampness, and removing liver fire to improve eyesight, and can be used for treating the xerophthalmia effectively.

Description

A kind of Chinese medicine preparation for the treatment of xerophthalmia and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of xerophthalmia, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Xerophthalmia refers to that the tear matter that any reason causes or amount exception or kinetics are abnormal, causes tear film stability to decline, and the general name of various diseases with ophthalmic uncomfortable and (or) eye table organization characteristics of lesion.Also known as angle conjunctival xerosis.Common symptom comprise eyes dry and astringent, easily tired, ophthalmic pruritus, have that foreign body sensation, pain burning sensation, secretions are sticky, aversion to wind, photophobia, to external world stimulate very sensitive; Sometimes eyes are too dry, basic oligodacrya, stimulate reflexive lacrimal secretion on the contrary, and cause and usually shed tears; More severe case eyes can redness, hyperemia, keratinization, corneal epithelium broken skin and have filament to stick, this damage with the passing of time then can cause angle conjunctive disorder, and can affect one's power of vision.Nearest research is thought, the change etc. of the change on eye surface, the inflammatory reaction based on immunity, apoptosis, sex hormone level is the correlative factor that development occurs xerophthalmia, and relation between each factor is not yet clear.The cause of disease can be divided into following four classes: 1. water liquid layer lachrymal gland lacrimal secretion is not enough: be modal xerophthalmia angle reason; Congenital alacrima gland, senile lacrimal gland function reduce or some autoimmune diseasees cause lacrimal gland inflammation, wound, infection, vegetative dystonie, put some collyrium for a long time or take some drugs and lacrimal secretion all can be caused not enough; The person that wears contact lens for a long time.2, oil layer hyposecretion: because eyelid disease causes tarsal glands dysfunction.3, mucin layer hyposecretion: the A1 person that is deficient in vitamin, chronic conjunctivitis, chemical burn etc.4, tear excessive vaporization, tear film skewness: eyelid disease causes that catacleisis is bad, number of winks reduces, rest on for a long time in cold air room or the scorching environment of outdoor high wind.

At present along with the development of modern science and technology, large-screen mobile phone, computer, LCD TV enter daily life, become the necessary of life; Especially gang of office, works for a long time before computer, and the eyes of computer display screen to people cause very large injury, and xerophthalmia is one of commonly encountered diseases; According to incompletely statistics, China is existing about has 30,000,000 people to suffer from the xerophthalmia of varying degree, and investigation confirms, work before computer every day more than 3 hours and wear for a long time in the people of contact lens, the people of 90% suffers from xerophthalmia.

Xerophthalmia is chronic disease, needs long-term treatment more.If because eyelid exposes the tear excessive vaporization type xerophthalmia caused, the opportunity of operation should holding restore eyelid according to the state of an illness carries out the reconstruction of eyelid.Doctor trained in Western medicine mainly adopts artificial tears, contact lens, lacrimal point to close, block lacrimal ductule and parotid gland transplantation treatment xerophthalmia; wherein; artificial tears is the most frequently used; artificial tears is a kind of imitation human body tear; can play a protective role to normal eyes; eliminate ophthalmic uncomfortable, treatment xerophthalmia, alleviates the eye care product of other oculopathy caused by xerophthalmia.But artificial tears does not play therapeutical effect to xerophthalmia, needs of patients life-time service artificial tears, the symptom of ability reduction of patient, brings great misery to patient.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of xerophthalmia, this Chinese medicine preparation has determined curative effect for xerophthalmia, cheap, safe ready, and side effect is little, the feature not easily recurred.

Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment xerophthalmia.

Inventor is in clinical treatment practice for many years, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of xerophthalmia repeatedly, the present invention selects Fructus Lycii, the Radix Paeoniae Alba, Cortex Mori, Cortex Lycii, Semen Armeniacae Amarum, Herba Lophatheri, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Rhizoma Alismatis, Radix Gentianae, Radix Ophiopogonis, Cortex Moutan, Radix Scrophulariae, Radix Scutellariae, Poria, Medulla Tetrapanacis, Flos Chrysanthemi, Periostracum Cicadae, Fructus Mume, Flos Inulae, Herba Dendrobii, Rhizoma Polygonati Odorati, Radix Saposhnikoviae, Herba Schizonepetae, Radix Glycyrrhizae combines, by these drug regimens, each efficacy of drugs is made to produce synergism, make it that there is nourishing the liver and kidney, replenishing vital essence to improve eyesight, heat clearing and damp drying, effect of liver heat removing and eyesight improving, thus effectively can treat xerophthalmia.

The effect of Chinese medicine of the present invention:

Wherein:

Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Nature and flavor: sweet, flat.Return liver, kidney channel.Effect: nourishing the liver and kidney, replenishing vital essence to improve eyesight.Cure mainly: caused by liver and kidney deficiency; Have a dizzy spell; Visual unclear; Soreness of the waist and knees; Impotence and seminal emission; Cough due to consumptive disease; To quench one's thirst taking fluids profusely.Fructus Lycii contains the required nutrition of the healthy eye such as calcium, ferrum such as abundant carotene, retinol1, B1, B2, C, therefore is good at improving eyesight, so be commonly called as " bright eye ".The blurring of vision that ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN cause and nyctalopia, usually use Fructus Lycii.

The Radix Paeoniae Alba: be the dry root of dicotyledon ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: cool, picric acid, is slightly cold.Effect: easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receives antiperspirant.Research shows: the paeoniflorin contained in the Radix Paeoniae Alba has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.This product energy nourishing the liver blood, holding back liver-yin, subduing the hyperfunction of the liver sun, dispersing liver-energy, can delay again that contraction is anxious, relieve the pain pain, is the good medicine of the various pain for the treatment of Liver Channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " purgation of spleen excess heat, only abdomen pain, sealing rushes down, and receives adverse flow of liver-QI pain, takes good care of conscience spleen channel blood, relax through sending down the abnormal ascending QI, only irritability pain." " herbal classic " Radix Paeoniae, though respectively in vain not red, the two is master to some extent respectively.So seek and unravel silk it and cure mainly all diseases, one is that replenishing blood and nourishing liver spleen is Kidney-Yin, and receives and take the photograph the at random of temper, and throwing off restraint of irritability is horizontal, then the Radix Paeoniae Alba.

Cortex Mori: be the dry root bark of moraceae plants Mulberry Morus alba L..Nature and flavor: sweet, cold.Return lung meridian.Effect: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For dyspnea and cough due to lung-heat, edema distension oliguria, appearance skin edema.Lung qi, regulating fluid apssage and inducing diuresis to remove edema can fall clearly in this product, with controlling hydrosarca, dysuria, edema of the face person, often join Cortex Sclerotii Poriae, Pericarpium Arecae is equivalent uses.

Cortex Lycii: be the dry root bark of matrimony vine of solanaceae plant Lycium chinense Mill. or lycium barbarum Lycium barbarum L..Nature and flavor: sweet, cold.Return lung, liver, kidney channel.Function cures mainly: removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.Record in " book on Chinese herbal medicine is stated ": cure mainly deficient fever, alternate attacks of chills and fever, allly see blood disorder, epistaxis, cough blood, cough, breathe heavily, diseases due to endogenous heat of ZANG FU organs, apoplexy, dizzy, convulsion is chronic, lumbago, migratory arthralgia, beriberi, edema, and fidgets due to deficiency is throbbed with fear, forgetful, urinary obstruction, reddish and whitish turbid urine.

Semen Armeniacae Amarum: be the dry mature seed of rosaceous plant Prunus armeniaca L.var.ansu Maxim. (bitter Fructus Pruni) Prunus armeniaca L. var. ansu Maxim., Siberia Fructus Pruni (Prunus armeniaca L.var.ansu Maxim.) Prunus sibirica L., prunus mandshuricaKoehne Prunus mandshurica (Maxim.) Koehne or Fructus Pruni Prunus armeniaca L..Nature and flavor: bitter, tepor; Slightly poisonous.Return lung, large intestine channel.Effect: sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.

Herba Lophatheri: be the dry stem and leaf of grass Herba Lophatheri Lophatherum gracile Brongn..Nature and flavor: sweet, light, cold.GUIXIN, stomach, small intestine meridian.Clearing heat and relieving fidgetness, diuresis.For calentura excessive thirst, hot urination drenches pain, aphtha of the mouth and tongue.Can clearing away heart-fire and antipyretic in this product, can fall small intestine fire and diuresis down, burning hot heresy can be made descending, from urine clearly, therefore can be used for the aphtha of the mouth and tongue of flaming up of heart-fire, and heat in the heart moves down the puckery pain of oliguria with reddish urine caused by small intestinal, often join Caulis Akebiae, the Radix Rehmanniae etc.

Pericarpium Citri Reticulatae: be the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor: temperature are pungent, bitter.Enter spleen, stomach, lung meridian.Effect: regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.This product temperature can circulation of qi promoting, pungently can disperse, bitter and sluice.Pericarpium Citri Reticulatae and the same use of Fructus Aurantii Immaturus, acrid in the mouth circulation of qi promoting, fragrance enters spleen, therefore can promoting the circulation of QI to relieve pain, spleen invigorating and in, Pericarpium Citri Reticulatae and the Rhizoma Pinelliae can drying dampness to eliminate phlegm with use, again can warming for resolving cold-phlegm.

The Rhizoma Pinelliae: be the tuber at the Rhizoma Arisaematis section plant Rhizoma Pinelliae (Pinellia ternata (Thunb.) Breit.).Nature and flavor: pungent, temperature, poisonous.Enter spleen, stomach warp.Effect: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.The pungent loose warm-dryness syndrome of these product is poisonous, main enter taste double enter lung, water of manageing it wets, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.Water is wet to be gone, and the strong and sputum of spleen is from disappearing, and inverse gas falls then harmonization of the stomach and feeling of fullness vomiting from only, therefore is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.Both cure mainly the abundant expectoration cough with asthma QI rising in reverse order of spleen damp-phlegm heap soil or fertilizer over and around the roots, control again the dizzy palpitation and insomnia that damp-phlegm is violated." property of medicine opinion ": expectorant saliva, appetite promoting and the spleen strengthening, anti-nausea, go expectorant in the heart full, lower lung qi, master coughs knot.New survivor rub be coated with carbuncle do not disappear, can tumor wart be removed.

Rhizoma Alismatis: be the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Nature and flavor: sweet, cold.Return kidney, urinary bladder channel.Effect: diuresis, clearing away damp-heat.For edema, the dysuria of retention of water-damp in the body.This product enters kidney, urinary bladder channel, and kind clear damp-heat in lower-JIAO cold in nature, is used for syndrome of dampness-heat in lower jiao.Rhizoma Alismatis has significant diuresis, can promote muriatic excretion, increases urine volume, more obvious to nephritis patient diuresis, has blood pressure lowering, hypoglycemic activity, also has lipotropic effect.

Radix Gentianae: be the dry root and rhizome of gentianaceae plant Gentiana manshurica Gentiana manshurica Kitag., Radix Gentianae Gentiana scabra Bunge, G. triflora Gentiana triflora pall or Gentiana rigescens Franch Gentiana rigescens Franch..Nature and flavor: bitter, cold.Return liver, gallbladder meridian.Effect: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.Being used for the treatment of jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, this product Great Cold, heat clearing and damp drying, outstanding kind liver heat removing gallbladder and damp-heat in lower-JIAO, is the common medicine of clearing liver-gallbladder and damp-heat in lower-JIAO.

Radix Ophiopogonis: be the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..Nature and flavor: sweet, micro-hardship, to be slightly cold.GUIXIN, lung, stomach warp.Effect: reinforcing stomach reg fluid, nourishing lung-YIN, clear away heart-fire relieving restlessness.Radix Ophiopogonis can clear away heart-fire in yin nourishing, and relieving restlessness is calmed the nerves.The heart-nutriment, fever aggravated at night is entered with controlling warm febrile disease.Normal and Herba Dendrobii matches.

Cortex Moutan: be the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor: bitter, cool.GUIXIN, liver, kidney, lung meridian.Effect: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.This product cold nature, can clearing heat in YING system divide, blood system excess-heat, have the merit of cooling blood for hemostasis, and Cortex Moutan is pungent cold, is apt to into blood system, can removing heat from blood with hemostasis, can invigorate blood circulation with dissipating blood stasis again, the kind logical heat in blood stasis of blood is stagnant, normal with Radix Rehmanniae, Radix Paeoniae Rubra is same uses.For the disease such as sore and toxic, acute appendicitis, this product is also conventional medicine.Treating carbuncle sore can coordinate heat and toxic materials clearing away medicine as Fructus Forsythiae, Herba Violae and so on; Controlling acute appendicitis can use equivalent with Radix Et Rhizoma Rhei from the beginning of failing pus person.This product with eliminating carbuncle, can be used for acute appendicitis and carbuncle sore tumefacting virus by clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, and the acute appendicitis initial stage can compatibility Radix Et Rhizoma Rhei, also can join the resolving heat and reducing pathogenic fire such as Flos Lonicerae, Fructus Forsythiae.

Radix Scrophulariae: be the dry root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl..Nature and flavor: sweet, bitter, salty, are slightly cold.Return lung, stomach, kidney channel.Effect: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.There is clearing away heat and cooling blood, effect of removing toxic substances YIN nourishing.Control warm febrile disease to join the army blood, impairment of YIN robs the fever of the body excessive thirst caused by liquid, uneasy sleeping at night, crimson tongue person, can share with the medicine such as the Radix Rehmanniae, Cornu rhinocerotis, Radix Salviae Miltiorrhizae.

Radix Scutellariae: be the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Nature and flavor: bitter, cold.Return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.The clinical practice of Radix Scutellariae is antibacterial relatively good, and does not develop immunity to drugs.This product has the merit of clearing away heat and cooling blood hemostasis, intimately flourishing with controlling, the haematemesis of the absurd row of forcing blood, and metrorrhagia, has blood in stool, and normal being equal to Radix Rehmanniae, Rhizoma Imperatae is used.

Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Sweet the providing additional supplies of this product is oozed, and not only mends but also sharp, and effect is gentle, and property is flat and partially without cold and heat, is the key medicine of promoting diuresis to eliminate damp pathogen.Treatment water wet the edema of expert time, often join Rhizoma Alismatis, Polyporus.Poria decoct has obvious sedation." modality ": " cure mainly Ji Rou Shun muscle of throbbing with fear cautious, dizziness agitation is controlled on side." this product is by heart-spleen boosting and tranquilizing mind.Be used for deficiency of both the heart and spleen, the irritability of insufficiency of vital energy and blood.

Medulla Tetrapanacis: be the dry stem pith of Araliaceae rice-paper plant Tetrapanax papyriferus (Hook.) K. Koch.Nature and flavor: sweet, light, be slightly cold.Attach to the lung and stomach meridians.Effect: clear snobbish water; Lactogenesis.The puckery pain of main stranguria; Dysuria; Edema; Jaundice; Damp-warm diseases; Oliguria with reddish urine; Puerperal, breast was few; Amenorrhea; Leukorrhagia.Modern pharmacology is studied: Medulla Tetrapanacis has diuresis, and obviously can increase urine potassium output, has effects such as promoting galactopoiesis.Medulla Tetrapanacis polysaccharide has certain immunity moderation and antioxidative effect.

Flos Chrysanthemi: be the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..Nature and flavor: sweet, bitter, are slightly cold.Return lung, Liver Channel.Effect: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.Flos Chrysanthemi dispelling wind is more weak, and heat clearing away power is good, often joins the same use of Folium Mori, also can join Radix Scutellariae, Fructus Gardeniae controls the diseases such as intenseness of heat is fidgety for affection due to external wind and heat.Flos Chrysanthemi controls conjunctival congestion and swelling pain, no matter belongs to liver-fire or wind heat causer, all can apply, and because this product can clearing away liver-fire, wind heat of faling apart again, often coordinates that Periostracum Cicadae, Fructus Atriplicis Sibiricae are equivalent to be used.

Periostracum Cicadae: exuviae shell when the larva for cicada Cryptotympana atrata Fabr. Cryptotympana pustulata Fabricius sprouts wings.Nature and flavor: sweet, cold.Return lung, Liver Channel.Effect: dispelling wind and heat pathogens, rash are antipruritic, improving acuity of vision and removing nebula, endogenous wind stopping relieving convulsion.This product a surname is loose to be sent out thoroughly, wind-dispelling heat-dissipating, and rash antipruritic can be used for treats measles, eczema etc., pterygium swollen for conjunctival congestion.The conjunctival congestion that this product causes wind heat, cataracta, and the raw nebula film of order after measles, have improving acuity of vision and removing nebula effect, can join the application such as Flos Chrysanthemi, Flos Eriocauli, Fructus Atriplicis Sibiricae.

Fructus Mume: be the dry almost ripe fruit of rose department plant plum Prunus mume (Sieh.) Sieb .et Zucc..Nature and flavor: sweet, sour, puckery, warm.Return stomach, large intestine channel.Effect: relieving diarrhea with astringents, astringing to arrest bleeding, expelling pus and promoting granulation.This product is used for not closing up for a long time after carbuncle sore is burst, and external has the effect of removing dampness expelling pus and promoting granulation." Bencao Jingshu ": Fructus Mume, namely the Fructus Mume of the present is also, the sourest." warp " is said: heat impairing vital QI, and evil visitor is in the heart, then gas superinverse and stuffy sensation with restlessness, the heart is uneasy for it.Fructus Mume sour in the mouth, can hold back superficial heat, air-breathing can return unit, therefore the main therapeutic method to keep the adverse QI flowing downwards, heat extraction stuffy sensation with restlessness and feeling at ease also.Dysentery person, large intestine collapse is also; Good saliva xerostomia person, hyperactivity of deficient fire, deficiency of body fluid is also; Acid can hold back asthenic fire, change body fluid, solid intestinal take off, so lead also.Its main limb pain, hemiplegia meciless person, covers because dampness is dipped in meridians, then muscle arteries and veins relaxes vertical, or pain is meciless; Liver governing tendons, sour in taste acting on the liver and nourishing muscle and tendon, liver obtain support, then solid skeleton and pliable tendons, machine-operated tonneau and front card removes.

Flos Inulae: for feverfew Flos Inulae (Inula britannica L.var. chinensis (Rupr.) Reg.), inula lineariifolia (Inula linariaefolia Turcz.) or Flos Caryophylli revolves or the head inflorescence of Flos Caryophylli Flos Inulae (Inula britannica L.) etc.Nature and flavor are salty, warm, slightly poisonous.Enter lung, liver, stomach warp.Effect: expectorant, the therapeutic method to keep the adverse QI flowing downwards, softening the hard mass, row water." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the head Zhu Fenghan that dispels is evil, only the sun, positive bright headache, the positive bright galactostasis of row.(controlling) breast carcinoma, acute mastitis, congestion and swelling pain, sudden and violent red acute catarrhal conjunctivitis, order disease pain, dispelling pathogenic wind for improving eyesight, hidden puckery photophobia are afraid of day, and the cough of cold cold and heat, old expectorant, as glue, walk meridians, and only face abdomen of trembling with fear aches, and diuresis, controls tympanites, and wind-fire root of the tooth swells and ache.

Herba Dendrobii: be orchid dendrobium loddigesii Rolfe Dendrobium loddigesii Rolfe., Herba Dendrobii oculati Dendrobium fimbriatum Hook. var. oculatum Hook., the fresh or dry stem of HERBA DENDROBII Dendrobium chrysanthum Wall., Herba Dendrobii Dendrobium candidum Wall. ex Lindl. or Dendrobium nobile Dendrobium nobile Lindl..Nature and flavor: be slightly cold; Sweet.Return stomach, kidney channel.Function: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.Herba Dendrobii has obvious therapeutical effect to ophthalmic diseases." explaining abstruseness of the canon of materia medica ": Herba Dendrobii, Gan Keyue spleen, salty energy kidney tonifying, therefore many merits are dirty in water and soil two.But gas is wide slow, without the merit that victory is played, ancients with this tea in generation, very clearly on diaphragm.

Rhizoma Polygonati Odorati: be the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati Polygonatum odoratum (Mill.) Druce.Nature and flavor: sweet, are slightly cold.Attach to the lung and stomach meridians.Effect: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.This product sweet in the mouth, greasiness, soft and moist edible, be longer than yin nourishing, mainly act on taste, therefore take not imapirment of the spleen and stomach for a long time, cure mainly the few expectorant of dry cough caused by deficiency of lung-YIN, pharynx dryness of the tongue and epidemic febrile disease later stage, or Tianjin of occurring is few thirsty, inappetence, the diseases such as stomach discomfort because hyperpyrexia consumption impairment of body fluid liquid.The merit that this product is mended and oiliness, cold not dry, therefore has " tonification the five internal organs, nourish QI and blood, flat benefit and moistening, and hold concurrently except wind heat ", has the effect of nourishing calm neural and heart tonifying.Be applicable to cardiopalmus, angina pectoris.Confirm through modern medicine study, Rhizoma Polygonati Odorati also has hypoglycemic activity, also has moist skin, and the effect of spraining is got injured by a fall in dissipation skin chronic inflammatory disease and treatment.

Radix Saposhnikoviae: be the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk..Nature and flavor: pungent, sweet, tepor.Return bladder, lung, spleen, Liver Channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.For diseases caused by exogenous pathogenic factor exterior syndrome or rubella pruritus.This product slightly warm in nature and not dry, sweet slow and not high, there is the title of " the profit agent in wind medicine ", no matter wind and cold, wind heat exterior syndrome all can be applied.This product also can be used for tetanus, gnathospasma, opisthotonus.Radix Saposhnikoviae controls tetanus, has the effect of expellingging wind and relieving convulsion.

Herba Schizonepetae: be the dry aerial parts of labiate Herba Schizonepetae Schizonepeta tenuifolia Briq..Nature and flavor: pungent, bitter, micro-wet.Return lung, Liver Channel.Effect: dispel the wind; Induce sweat; Rash; Hemostasis.Main cold, fever; Headache; Eye itching; Cough; Laryngopharynx swelling and pain; Measles; Carbuncle; Skin ulcer scabies; Epistaxis; Spit blood; Have blood in stool; Metrorrhagia; Puerperal blood faints.This product Chhnang is loose thoroughly, can dispelling wind for relieving itching, and the loose measles toxin of a surname, can be used for measles without adequate eruption, rubella pruritus, in addition Herba Schizonepetae also can be used for skin infection from the beginning of, relatively wind heat this, compatibility Flos Loniceraes etc., Herba Schizonepetae and Radix Saposhnikoviae mutual reinforcement between are use, strengthen expelling pathogenic wind from the body surface effect.

Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.

Side's solution of the present invention is: Fructus Lycii nourishing the liver and kidney, replenishing vital essence to improve eyesight in side, and the traditional Chinese medical science thinks that xerophthalmia is because pathogenic heat are reluctant to leave, lung YANG deficiency, retention of heat in the spleen and stomach and hepatic and renal YIN deficiency, deficiency of YIN-blood and causing caused by eyes losing nutrition.Tear is the fluid of the liver, hepatic and renal function imbalance or deficiency of liver-blood, it is foster that order loses moistening of liver blood and body fluid, causes eyes dry and astringent.Fructus Lycii contains the required nutrition of the healthy eye such as calcium, ferrum such as abundant carotene, retinol1, B1, B2, C, fundamentally treating from disease, the Radix Paeoniae Alba is enriched blood easing the affected liver, suppressing the hyperactive liver pain relieving, Cortex Mori eliminating pathogen from the lung for relieving asthma, Cortex Lycii, Semen Armeniacae Amarum lung heat clearing pathogenic fire reducing, the above five tastes are monarch drug altogether, fundamentally fall clearly lung-fire, nourishing the liver and kidney, disease therapy.Herba Lophatheri clearing heat and relieving fidgetness, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, Rhizoma Pinelliae drying dampness to eliminate phlegm, Rhizoma Alismatis clearing away damp-heat, Radix Gentianae heat clearing and damp drying, Radix Ophiopogonis reinforcing stomach reg fluid, nourishing lung-YIN, Cortex Moutan clearing away heat and cooling blood, above seven tastes are ministerial drug altogether, increase effect of monarch drug liver heat removing and eyesight improving, nourishing the liver and kidney, and there is the effect of heat clearing and damp drying, calm down liver-fire, the eye-candy portion of scholar, and then the improvement accelerating the state of an illness.Radix Scrophulariae clearing away heat and cooling blood, Radix Scutellariae heat clearing and damp drying, Poria promoting diuresis to eliminate damp pathogen, the clear snobbish water of Medulla Tetrapanacis, Flos Chrysanthemi heat clearing away is dispelled the heat, liver heat removing and eyesight improving, Periostracum Cicadae wind-dispelling heat-dissipating, Fructus Mume astringing to arrest bleeding, the capable water of Flos Inulae softening the hard mass, Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat, Rhizoma Polygonati Odorati nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst, Radix Saposhnikoviae, Herba Schizonepetae expelling pathogenic wind from the body surface, removing dampness to relieve pain, a few taste is adjuvant drug altogether above, not only increase monarch drug, the drug effect of ministerial drug, and reinforcing stomach reg fluid, nourishing YIN and moistening the lung, contact all to some extent between the five internal organs, reinforcing stomach reg fluid, strengthen the conversion of grain rice, make vital essence up, nourishing eyes, promote that patient recovers.Radix Glycyrrhizae priming is returned through, coordinating the actions of various ingredients in a prescription, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has effect of nourishing the liver and kidney, replenishing vital essence to improve eyesight, heat clearing and damp drying, liver heat removing and eyesight improving, effectively can treat xerophthalmia.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Fructus Lycii 13-23 part, Radix Paeoniae Alba 10-20 part, Cortex Mori 10-20 part, Cortex Lycii 13-23 part, Semen Armeniacae Amarum 7-17 part, Herba Lophatheri 7-17 part, Pericarpium Citri Reticulatae 5-15 part, Rhizoma Pinelliae 4-14 part, Rhizoma Alismatis 7-17 part, Radix Gentianae 4-14 part, Radix Ophiopogonis 10-20 part, Cortex Moutan 7-17 part, Radix Scrophulariae 10-20 part, Radix Scutellariae 10-20 part, Poria 10-20 part, Medulla Tetrapanacis 3-9 part, Flos Chrysanthemi 5-15 part, Periostracum Cicadae 3-9 part, Fructus Mume 15-25 part, Flos Inulae 4-14 part, Herba Dendrobii 7-17 part, Rhizoma Polygonati Odorati 7-17 part, Radix Saposhnikoviae 4-14 part, Herba Schizonepetae 5-15 part, Radix Glycyrrhizae 4-14 part.

Wherein be preferably: Fructus Lycii 18 parts, the Radix Paeoniae Alba 15 parts, Cortex Mori 15 parts, Cortex Lycii 18 parts, Semen Armeniacae Amarum 12 parts, Herba Lophatheri 12 parts, Pericarpium Citri Reticulatae 10 parts, the Rhizoma Pinelliae 9 parts, Rhizoma Alismatis 12 parts, Radix Gentianae 9 parts, Radix Ophiopogonis 15 parts, Cortex Moutan 12 parts, Radix Scrophulariae 15 parts, Radix Scutellariae 15 parts, 15 parts, Poria, Medulla Tetrapanacis 6 parts, Flos Chrysanthemi 10 parts, Periostracum Cicadae 6 parts, Fructus Mume 20 parts, Flos Inulae 9 parts, Herba Dendrobii 12 parts, Rhizoma Polygonati Odorati 12 parts, Radix Saposhnikoviae 9 parts, Herba Schizonepetae 10 parts, Radix Glycyrrhizae 9 parts.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug pulverize mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.

The preferred preparation method of the present invention is decoction, and its preparation method is as follows:

Step one: by weight proportion of the present invention, first becomes medicated bag by Fructus Lycii, Semen Armeniacae Amarum, Fructus Mume bundle, is put in water and soaks about 45 minutes, filters, for subsequent use;

Step 2: by weight proportion of the present invention, take the Radix Paeoniae Alba, Cortex Mori, Cortex Lycii, the Rhizoma Pinelliae, Rhizoma Alismatis, Radix Gentianae, Radix Ophiopogonis, Cortex Moutan, Radix Scrophulariae, Radix Scutellariae, Rhizoma Polygonati Odorati, Radix Saposhnikoviae is put in marmite to add in step one and remains cold water after immersion, exceed powder 4 ~ 6 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 4 cm is added in residue medicinal residues, then Pericarpium Citri Reticulatae is added, Herba Dendrobii, Poria, Medulla Tetrapanacis, Periostracum Cicadae, medicated bag in Herba Schizonepetae and step one, decoct 20-30 minute, finally add Flos Chrysanthemi, Flos Inulae, Herba Lophatheri, Radix Glycyrrhizae decocts 10 minutes, filter, waste, obtain filtrate, for subsequent use,

Step 3: twice filtrate in step 2 is merged, both the Chinese medicine decoction for the treatment of xerophthalmia of the present invention.

Medicine of the present invention has effect of nourishing the liver and kidney, replenishing vital essence to improve eyesight, heat clearing and damp drying, liver heat removing and eyesight improving, and determined curative effect, cheap, safe ready, side effect is little, not easily recurs, the mode that this Chinese medicine preparation adopts is treated and can be removed xerophthalmia and bring inconvenience on live and work to patient, according to clinical 160 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 85%, two the total effective rate course for the treatment of 97.5%.

Detailed description of the invention

Embodiment one, Fructus Lycii 13 parts, the Radix Paeoniae Alba 10 parts, Cortex Mori 10 parts, Cortex Lycii 13 parts, Semen Armeniacae Amarum 7 parts, Herba Lophatheri 7 parts, Pericarpium Citri Reticulatae 5 parts, the Rhizoma Pinelliae 4 parts, Rhizoma Alismatis 7 parts, Radix Gentianae 4 parts, Radix Ophiopogonis 10 parts, Cortex Moutan 7 parts, Radix Scrophulariae 10 parts, Radix Scutellariae 10 parts, 10 parts, Poria, Medulla Tetrapanacis 3 parts, Flos Chrysanthemi 5 parts, Periostracum Cicadae 3 parts, Fructus Mume 15 parts, Flos Inulae 4 parts, Herba Dendrobii 7 parts, Rhizoma Polygonati Odorati 7 parts, Radix Saposhnikoviae 4 parts, Herba Schizonepetae 5 parts, Radix Glycyrrhizae 4 parts.

Embodiment two, Fructus Lycii 18 parts, the Radix Paeoniae Alba 15 parts, Cortex Mori 15 parts, Cortex Lycii 18 parts, Semen Armeniacae Amarum 12 parts, Herba Lophatheri 12 parts, Pericarpium Citri Reticulatae 10 parts, the Rhizoma Pinelliae 9 parts, Rhizoma Alismatis 12 parts, Radix Gentianae 9 parts, Radix Ophiopogonis 15 parts, Cortex Moutan 12 parts, Radix Scrophulariae 15 parts, Radix Scutellariae 15 parts, 15 parts, Poria, Medulla Tetrapanacis 6 parts, Flos Chrysanthemi 10 parts, Periostracum Cicadae 6 parts, Fructus Mume 20 parts, Flos Inulae 9 parts, Herba Dendrobii 12 parts, Rhizoma Polygonati Odorati 12 parts, Radix Saposhnikoviae 9 parts, Herba Schizonepetae 10 parts, Radix Glycyrrhizae 9 parts.

Embodiment three, Fructus Lycii 23 parts, the Radix Paeoniae Alba 20 parts, Cortex Mori 20 parts, Cortex Lycii 23 parts, Semen Armeniacae Amarum 17 parts, Herba Lophatheri 17 parts, Pericarpium Citri Reticulatae 15 parts, the Rhizoma Pinelliae 14 parts, Rhizoma Alismatis 17 parts, Radix Gentianae 14 parts, Radix Ophiopogonis 20 parts, Cortex Moutan 17 parts, Radix Scrophulariae 20 parts, Radix Scutellariae 20 parts, 20 parts, Poria, Medulla Tetrapanacis 9 parts, Flos Chrysanthemi 15 parts, Periostracum Cicadae 9 parts, Fructus Mume 25 parts, Flos Inulae 14 parts, Herba Dendrobii 17 parts, Rhizoma Polygonati Odorati 17 parts, Radix Saposhnikoviae 14 parts, Herba Schizonepetae 15 parts, Radix Glycyrrhizae 14 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Accept out-patient 320 example for medical treatment, patient is divided into observation group and matched group at random, wherein male 172 example, women 148 example, M-F 1.16:1,32 years old mean age, the course of disease time is not etc.Every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).

Two, diagnostic criteria:

The industry standard " Chinese medical disease Standardization of diagnosis and curative effect " that diagnostic criteria is promulgated with reference to State Administration of Traditional Chinese Medicine:

1, eye dry and astringent, mill pain, photophobia, can be dry with mouth and nose;

2, jade-like stone profit gloss is lost in the drying of order pearl, and white of the eye is micro-red, the raw nebula of black eyeball, and a lot of secretion in the eye is sticky;

3, lacrimal secretion quantitative determination, repeatedly Schirmer I method is less than 10mm/5min, and corneal fluorescein dye test is positive.

Three, Therapeutic Method:

1, according to Medications Example two of the present invention, and preparation prepared by selected preparation method, getting a daily dose, decocting, take at twice, 20 days is a course for the treatment of.

2, matched group is according to western medicine routine treatment method, treats patient, and the observation period is 20 days.

Four, efficacy assessment standard:

The industry standard " Chinese medical disease Standardization of diagnosis and curative effect " that criterion of therapeutical effect is promulgated with reference to State Administration of Traditional Chinese Medicine.

Cure: transference cure, corneal dyeing disappears, and Schirmer I tests repeatedly to measure and is greater than 10mm/5mim;

Take a turn for the better: symptom alleviates, corneal dyeing reduces, and SchirmerI test repeatedly measures lacrimal secretion to be increased to some extent;

Do not heal: symptom is without improvement, and corneal dyeing is unchanged or increase, SchirmerI test repeatedly measures lacrimal secretion and does not increase.

Five, observation group's result statistics

Matched group result is added up

Wherein: total effective rate=cure rate+improvement rate

Can find that observation group is apparently higher than matched group, illustrates thus by the treatment total effective rate contrasting two groups of patients, Chinese medicine of the present invention has good clinical effectiveness in treatment xerophthalmia, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.

Model case and curative effect:

Case one, patient Zhang, man, 21 years old, patient is for a long time to the machine of setting about, computer is played games, nearest patient occurs that eyes are dry and astringent, easily tired, the symptoms such as itching eyes, patient goes to hospital to check, conjunctival xerosis, eyelid internal congestive, lacrimal secretion presents the positive, finally be diagnosed as xerophthalmia, patient starts to adopt the mode of artificial tears to treat, but can only mitigation be played, one drug withdrawal still there will be the sensation of ophthalmic uncomfortable, patient adopts made preparation in the embodiment of the present invention two, and the preferred preparation method of institute, after taking treatment a period of time, eyes are dry and astringent, the symptom of itching is eased, continue to take a course for the treatment of, patient's readme eyes sense of discomfort disappears completely, remove examination in hospital, corneal dyeing disappears, Schirmer I tests repeatedly to measure and is greater than 10mm/5mim, recovery from illness.

Case two, patient Zhao, female, 29 years old, patient is office's white collar, long-time facing to computer, eyes can not get having a rest, the bad habit that patient sees the mobile phone before also having sleep evening, there is photophobia in nearest patient's eye, aversion to wind, itch, the symptom such as dry and astringent, originally patient adopts the mode of eye drop water to treat, sour and astringent, the phenomenon of distending pain improves a little, but a drug withdrawal, the symptom of ophthalmic uncomfortable there will be again, patient removes examination in hospital, finally be diagnosed as xerophthalmia, adopt made preparation in the embodiment of the present invention two, and selected preparation method, after taking two courses for the treatment of, the phenomenon of eye's discomfort obviously disappears, for preventing recurrence, patient adheres to again having taken a course for the treatment of, the symptom of xerophthalmia all disappears, patient removes examination in hospital, every inspection is all normal, recovery from illness.

Claims (4)

1. treat the Chinese medicine preparation of xerophthalmia for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Fructus Lycii 13-23 part, Radix Paeoniae Alba 10-20 part, Cortex Mori 10-20 part, Cortex Lycii 13-23 part, Semen Armeniacae Amarum 7-17 part, Herba Lophatheri 7-17 part, Pericarpium Citri Reticulatae 5-15 part, Rhizoma Pinelliae 4-14 part, Rhizoma Alismatis 7-17 part, Radix Gentianae 4-14 part, Radix Ophiopogonis 10-20 part, Cortex Moutan 7-17 part, Radix Scrophulariae 10-20 part, Radix Scutellariae 10-20 part, Poria 10-20 part, Medulla Tetrapanacis 3-9 part, Flos Chrysanthemi 5-15 part, Periostracum Cicadae 3-9 part, Fructus Mume 15-25 part, Flos Inulae 4-14 part, Herba Dendrobii 7-17 part, Rhizoma Polygonati Odorati 7-17 part, Radix Saposhnikoviae 4-14 part, Herba Schizonepetae 5-15 part, Radix Glycyrrhizae 4-14 part.

2. the Chinese medicine preparation for the treatment of xerophthalmia according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Fructus Lycii 18 parts, the Radix Paeoniae Alba 15 parts, Cortex Mori 15 parts, Cortex Lycii 18 parts, Semen Armeniacae Amarum 12 parts, Herba Lophatheri 12 parts, Pericarpium Citri Reticulatae 10 parts, the Rhizoma Pinelliae 9 parts, Rhizoma Alismatis 12 parts, Radix Gentianae 9 parts, Radix Ophiopogonis 15 parts, Cortex Moutan 12 parts, Radix Scrophulariae 15 parts, Radix Scutellariae 15 parts, 15 parts, Poria, Medulla Tetrapanacis 6 parts, Flos Chrysanthemi 10 parts, Periostracum Cicadae 6 parts, Fructus Mume 20 parts, Flos Inulae 9 parts, Herba Dendrobii 12 parts, Rhizoma Polygonati Odorati 12 parts, Radix Saposhnikoviae 9 parts, Herba Schizonepetae 10 parts, Radix Glycyrrhizae 9 parts.

3. the Chinese medicine preparation for the treatment of xerophthalmia according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.

4. treat a preparation method for the Chinese medicine preparation of xerophthalmia, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, first Fructus Lycii, Semen Armeniacae Amarum, Fructus Mume bundle is become medicated bag, is put in water and soaks about 45 minutes, filters, for subsequent use, step 2: by weight proportion of the present invention, take the Radix Paeoniae Alba, Cortex Mori, Cortex Lycii, the Rhizoma Pinelliae, Rhizoma Alismatis, Radix Gentianae, Radix Ophiopogonis, Cortex Moutan, Radix Scrophulariae, Radix Scutellariae, Rhizoma Polygonati Odorati, Radix Saposhnikoviae is put in marmite to add in step one and remains cold water after immersion, exceed powder 4 ~ 6 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 4 cm is added in residue medicinal residues, then Pericarpium Citri Reticulatae is added, Herba Dendrobii, Poria, Medulla Tetrapanacis, Periostracum Cicadae, medicated bag in Herba Schizonepetae and step one, decoct 20-30 minute, finally add Flos Chrysanthemi, Flos Inulae, Herba Lophatheri, Radix Glycyrrhizae decocts 10 minutes, filter, waste, obtain filtrate, for subsequent use, step 3: twice filtrate in step 2 is merged, both the Chinese medicine decoction for the treatment of xerophthalmia of the present invention.