CN102406893A - Chinese patent medicine for treating psoriasis. - Google Patents
Chinese patent medicine for treating psoriasis. Download PDFInfo
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- CN102406893A CN102406893A CN2011103762963A CN201110376296A CN102406893A CN 102406893 A CN102406893 A CN 102406893A CN 2011103762963 A CN2011103762963 A CN 2011103762963A CN 201110376296 A CN201110376296 A CN 201110376296A CN 102406893 A CN102406893 A CN 102406893A
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Abstract
The present invention relates to the technical field of psoriasis treatment, particularly to the technical field of a Chinese patent medicine for treating psoriasis. The present invention has the following technical scheme that the Chinese patent medicine comprises the following raw materials by weight part: cortex moutan, red sage root, rehmanniae radix, Poria cocos, fructus leonuri, fried herba schizonepetae, indigowoad root, honeysuckle flower, radix macrotomiae, densefruit pittany root-bark, curcuma rhizome, safflower, dark plum, calcined oyster, radix paeoniae rubrathe and licorice. Compared with the prior art, the invention provides a Chinese patent medicine for eliminating the diseases of the patient, and promoting physical and mental health, and has the advantages of low treatment cost, convenient medicine administration, fast curative effect and no side-effect.
Description
Technical field
The present invention relates to psoriatic treatment technology field, relate in particular to a kind of technical field of treating psoriatic Chinese patent medicine.
Background technology
Psoriasis is a kind of common chronic dermatosis, and it mainly is on erythema, to occur the silvery white dry squama of multilamellar repeatedly.Traditional Chinese medical science Gu is referred to as “ Bai Mange ", ancient doctor's nationality also is referred to as psoriasis.Doctor trained in Western medicine is called psoriasis (Psoriasis), is commonly called as psoriasis, the pimple that it occurs differing in size, and erythema, surface coverage silvery white squama, clear border, the male is more than the women.The psoriasis easy relapse, winter in spring easy relapse or increase the weight of, and alleviate summer and autumn more.The position of morbidity is the most common with scalp, is shank, ancon, back, upper arm, forearm, knee, chest and abdominal part and buttocks etc. secondly.Often be symmetry and distribute, also can distribute along tegumentary nerve is the wire arrangement.
The patient is owing to scratch, near affected part and can also can have new flat hillock rash to occur it with scratch, petechia or blood crusts on every side; Conscious paroxysmal is very itched, and is more acute during by clothing friction and sweat stain, becoming severe at night, and that scratches does not know pain.During anxious state of mind, pruritus is aggravation thereupon also.Because of pruritus can influence work and rest, the patient often with insomnia, dizzy, irritated symptom, because of this disease course of disease is slow, do not heal by constant year, and outbreak often brings great body and mind misery and financial burden to the patient repeatedly.Because of the obstinate refractory of this disease, still classified as the important subject in department of dermatologry field, the world today, be one of whole world department of dermatologry keypoint control disease.In the psoriasis control; The traditional Chinese medical science, doctor trained in Western medicine and the combination of Chinese and Western medicine all have many patent medicine and successful Therapeutic Method, but have also brought many troubles to the patient, like having made of doctor trained in Western medicine anticarcinogen and hormone medicine; Its serious adverse has been brought more serious wrecking to patient's body; Its weak curative effect, outbreak makes the patient dissatisfied repeatedly, has not only brought many miseries to the patient, and has brought the medical expense of great number.Therefore, seek a kind of illness new, that can eliminate the patient, have take medicine conveniently, problem that curative effect is fast, the psoriatic Chinese patent medicine of treatment that have no side effect is still the present technique field technical staff needs to be resolved hurrily.
Summary of the invention:
Technical problem to be solved by this invention is the deficiency that overcomes prior art, and provides a kind of to eliminate patient's illness, promote physically and mentally healthy, the psoriatic Chinese patent medicine of treatment that have simultaneously that medical expense is low, the patient takes medicine conveniently, curative effect is fast, has no side effect.
For solving the problems of the technologies described above; The present invention adopts following technical scheme: the psoriatic Chinese patent medicine of a kind of treatment, its special character is to be prepared from following medicaments in part by weight: Cortex Moutan 15-45 part, Radix Salviae Miltiorrhizae 20-50 part, Radix Rehmanniae 15-45 part, Poria 15-45 part, Fructus Leonuri 15-45 part, Herba Schizonepetae (parched) 10-40 part, Radix Isatidis 15-45 part, Flos Lonicerae 15-45 part, Radix Arnebiae (Radix Lithospermi) 15-45 part, Cortex Dictamni 15-45 part, Rhizoma Curcumae 15-45 part, Flos Carthami 10-30 part, Fructus Mume 30-70 part, Concha Ostreae (calcined) 60-90 part, Radix Paeoniae Rubra 15-45 part, Radix Glycyrrhizae 5-35 part.
For further solving the problems of the technologies described above, the preferred version of said medicine weight portion is: Cortex Moutan 25-35 part, Radix Salviae Miltiorrhizae 30-40 part, Radix Rehmanniae 25-35 part, Poria 25-35 part, Fructus Leonuri 25-35 part, Herba Schizonepetae (parched) 20-30 part, Radix Isatidis 25-35 part, Flos Lonicerae 25-35 part, Radix Arnebiae (Radix Lithospermi) 25-35 part, Cortex Dictamni 25-35 part, Rhizoma Curcumae 25-35 part, Flos Carthami 15-25 part, Fructus Mume 40-60 part, Concha Ostreae (calcined) 70-80 part, Radix Paeoniae Rubra 25-35 part, Radix Glycyrrhizae 10-30 part.
For further solving the problems of the technologies described above, the preferred plan of said medicine weight portion is: 30 parts of Cortex Moutans, 35 parts of Radix Salviae Miltiorrhizaes, 30 parts in the Radix Rehmanniae, 30 parts in Poria, 30 parts of Fructus Leonuris, 25 parts of Herba Schizonepetae (parched), 30 parts of Radix Isatidis, 30 parts of Flos Loniceraes, 30 parts of Radix Arnebiae (Radix Lithospermi)s, 30 parts of Cortex Dictamnis, 30 parts of Rhizoma Curcumae, 20 parts on Flos Carthami, 50 parts of Fructus Mumes, 75 parts of Concha Ostreae (calcined)s, 30 parts of Radix Paeoniae Rubra, 20 parts in Radix Glycyrrhizae.
Above-mentioned described Chinese patent medicine is processed pill, sublimed preparation, powder, tablet, unguentum, decoction and the different oral medicine dosage form of capsule dress powder according to the conventional technology of preparing of Chinese medicine.
Above-mentioned described Chinese patent medicine also contains drug excipient.
Above-mentioned described Chinese patent medicine is as the application of treatment psoriasis disease.
The principles of formulating prescriptions of Chinese patent medicine of the present invention are: regulating the blood flow circulation, painful antipruritic, the cooling blood and dissolving purpura of clearing away heart-fire, expelling wind and removing dampness, kidney tonifying detoxifcation, town, enhancement telangiectasis improve immune function of human body, thereby reach the psoriatic purpose of treatment.The present invention has proper, the reasonable recipe of compatibility of drugs, and the effect of its said each herbal medicine is:
Cortex Moutan: bitter in the mouth, cool in nature, be slightly cold.GUIXIN, liver, kidney, lung meridian.Effect cures mainly: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and pounce on the pain of injury; The rheumatism pyretic arthralgia.
Radix Salviae Miltiorrhizae: bitter in the mouth, little suffering, cold nature; Go into the heart, spleen, liver, kidney footpath; Effect: have blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind, removing heat from blood repercussive effect; Cure mainly: blood stasis head, breast, the side of body, abdomen pain, gather, menoxenia, the dysmenorrhea amenorrhea, the stasis of blood stagnated and suffered from abdominal pain puerperal, arthralgia, the traumatic injury congestive edema, epidemic febrile disease is vexed, palpitation due to deficiency of blood, sore swollen toxin, red rash scabies.
The Radix Rehmanniae: another name: Radix Rehmanniae, marrow, smart, the benzyl root of sun, be goatweed.The property flat, bitter in the mouth, be used as medicine with ratan on the Chinese medicine, function heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow cure mainly diseases such as arthralgia.
Poria: sweet in the mouth, light; Property is put down; GUIXIN, spleen, lung, kidney channel; Effect: eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming; Cure mainly: dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, have loose bowels, palpitation and restlessness, insomnia forgetfulness, seminal emission nebulousurine.
Fructus Leonuri: acrid in the mouth, little hardship, cold nature; GUIXIN born of the same parents, Liver Channel; Function cures mainly: promoting blood flow to regulate menstruation, wind and heat dispersing; Control menoxenia, the metrorrhagia leukorrhagia, postnatal blood stasis is had a pain; The liver-heat headache, conjunctival congestion and swelling pain, or give birth to the nebula film.
Herba Schizonepetae (parched): acrid in the mouth, slightly warm in nature, return lung, Liver Channel, have the diffusing wind that induces sweat, rash, the skin ulcer that disappears, hemostatic effect, be usually used in treatment flu, measles pass through send out smooth, have blood in stool, diseases such as metrorrhagia, epistaxis.
Radix Isatidis: cold in nature, bitter in the mouth is nontoxic.Return liver, stomach warp; Effect: heat clearing away, detoxifcation, removing heat from blood, sore-throat relieving; Cure mainly: maculae caused by violent heat pathogen; The hyperpyrexia headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.
Flos Lonicerae: another name: Flos Lonicerae, little egret flower, Flos Lonicerae, Flos Lonicerae, golden rattan, two bud flower, JINHUA, two precious flowers; Cold in nature, sweet in the mouth; Gui Jing: lung; Stomach is through effect: heat-clearing and toxic substances removing cures mainly: the epidemic febrile disease heating; Toxic-heat and blood stasis; The carbuncle furuncle; Sore throat and multiple infectious disease.
Radix Arnebiae (Radix Lithospermi): cold in nature, bitter in the mouth, sweet, flat, be included into the heart, Liver Channel.Effect: removing heat from blood, invigorate blood circulation heat clearing away, detoxifcation.Cure mainly warm macule, jaundice due to damp-heat, purpura tells, nosebleed, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, diseases such as carbuncle and ulcer.
Cortex Dictamni: cold in nature, bitter in the mouth, return spleen, stomach, bladder, small intestine meridian; Effect is a heat clearing and damp drying, dispels the wind detoxifcation; The clinical damp and hot sore, pus all over nest, yellow fluid of being used for is dripping; And skin pruritus, skin ulcer tinea mange, pudendum disease, Cortex Dictamni such as swell and ache is to dispel the wind, remove damp and hot medicine; And but eliminating dampness by diuresis heat is applicable to diseases such as skin ulcer tinea pruritus due to damp pathogen in lower orifices, often cooperates medicines such as Radix Sophorae Flavescentis, the Fructus Kochiae with using; Both oral administration also can be fried in shallow oil the soup washout.
Rhizoma Curcumae: chemical analysis: rhizome contains volatile oil, and the composition that contains in the oil has Rhizoma Curcumae furanone, table Rhizoma Curcumae furanone, Rhizoma Curcumae furan hydrocarbon, curdione, curcumenol, Camphora, Borneolum Syntheticum etc.Warm in nature, bitter in the mouth, suffering are gone into liver, spleen channel.Function: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Be mainly used in abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate's distending pain, gather, women's blood stasis amenorrhea, the traumatic injury eating accumulation of having a pain.Promoting the circulation of QI to relieve pain, removing blood stasis removing food stagnancy: amenorrhea, chest and hypochondrium, stomachache and the lump in the abdomen lump etc. that are used for qi depression to blood stasis.Often join triangular.Promoting digestion and removing stagnation: be used for the stomach abdominal distention and pain of eating accumulation, often join Fructus Hordei Germinatus (parched to brown), Semen Arecae Prepareta.
Flos Carthami: acrid in the mouth, warm in nature, GUIXIN, Liver Channel.Function cures mainly: the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury.Be suitable for various varicosis, peripheral neuritis, blood circulation.Promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing, the fragrant row of gas looses, and goes into blood system and has promoting blood circulation to restore menstrual flow, and the effect of stasis-dispelling and pain-killing cures mainly dysmenorrhea, amenorrhea, puerperal blood faints, the stasis of blood stagnates and suffers from abdominal pain obstruction of qi in the chest and cardialgia, accumulation of blood, traumatic injury congestive edema, arthralgia, paralysis due to windstroke, macular eruption being dark-purple.
Fructus Mume: sour in the mouth, warm in nature; Be included into liver, spleen, lung, large intestine channel.Function cures mainly: the relieving colic caused by ascaris anthelmintic is promoted the production of body fluid in convergence.Control chronic cough, the deficiency-heat excessive thirst, chronic malaria, chronic diarrhea, dysentery is had blood in stool, hematuria, metrorrhagia, ascariasis of biliary tract stomachache, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp.
Concha Ostreae (calcined): with the Concha Ostreae of cleaning, put on the smokeless stove fire and forge to canescence, taking-up cools, and pulverizes.Salty in the mouth, cold nature; Return liver, kidney channel; Function with cure mainly: suppressing the hyperactive liver and subsiding YANG, tranquillization with heavy prescription, hard masses softening and resolving, convergence are astringent or styptic treatment for spontaneous sweating.Cure mainly: main vertigo and tinnitus, palpitation with fear insomnia, scrofula goiter, lump in the abdomen mass in the abdomen, spontaneous sweating, seminal emission, metrorrhagia, leukorrhagia.
Radix Paeoniae Rubra: sour in the mouth, hardship, cool in nature.Go into liver, spleen channel.Effect: clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control the stagnant amenorrhea of the stasis of blood, the hernia abdominal mass is gathered, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle.
Radix Glycyrrhizae: sweet in the mouth, property is flat; Return 12 warps.Effect: detoxifcation is arranged, eliminate the phlegm, pain relieving, spasmolytic be so that pharmacological action such as anticancer.On the traditional Chinese medical science, the Radix Glycyrrhizae invigorating the spleen and replenishing QI is grown and to be coughed lung moistening, and the emergency detoxifcation is in harmonious proportion hundred medicines.The clinical practice branch " is given birth to and uses " with " processed with honey " not.Give birth to curing mainly laryngopharynx swelling and pain cellulitis skin infection, gastrointestinal ulceration and separate poison of drug, alimentary toxicosis etc.; Processed with honey cures mainly spleen and stomach function and goes down, and big loose stool is thin, weak heating and cough, cardiopalmus etc.
The Chinese medicine and pharmacy theory is thought: from the beginning of the heresy retardance skin that is mostly rheumatic fever, or the neck hyperhidrosis, due to the stiffened cloth friction etc.; The sick impairment of YIN of consumption for a long time liquid, nutrient QI and blood being insufficient, wind syndrome due to blood-deficiency is given birth to dry, and failure of skin and muscle to be nourished forms; Blood-deficiency leading to hyperactivity of the liver, feelings will is unsuccessful, gloomyly do not relax, or nervous tired, flaming up of heart-fire, so that QI-blood circulation dereliction of duty, the skin that stagnates be prone to the key factor that becomes to bring out, and pathogenic feelings is shown effect repeatedly.In a word, feelings will internal injury, ailment said due to cold or exposure invasion and attack are risk factors of primary disease morbidity, and nutrient blood is become estranged, passages through which vital energy circulates loses and dredges, coagulation of QI-blood then is its pathogenesis.Therefore,
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", and all composition comes from the 5th edition medicine that records of China's " pharmacopeia ", and all medicines have temperature compensation liver spleen mutually and altogether; The wind dehumidifying of loosing, the QI and blood regulating, is set upright and is got rid of evils dredge the meridian passage, blood circulation promoting and blood stasis dispelling; Regulate immunologic function, improve skin microcirculation, reach treatment and prevention psoriasis disease, determined curative effect; Have no side effect various Chinese medicine preparation taking conveniences.
The clinical use result of Chinese patent medicine of the present invention shows to have following advantage:
1, the Chinese medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment and the prevention psoriasis disease of the Chinese medicine of respectively distinguishing the flavor of, and is harmless to human non-toxic.Acute toxicity test and accumulation toxicity test through white mice and rat show that underproof animal does not see any toxic reaction; Compare zero difference through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group, prove that its safety of medicine is reliable.
2, Chinese patent medicine preparation of the present invention need not decoct, not have bitterness sense; Rich in proteins, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid in the medicine; Also contain various trace elements such as Saponin, plant sterol, calcium; Help absorption of human body, health invigorating, and taking convenience.
But 3, Chinese patent medicine preparation of the present invention efficacious therapy psoriasis disease not only; And it is also very obvious to the preventive effect of psoriasis disease; Particularly pass through working in coordination with each other between the medicine, strengthen medicine and treat characteristic separately, through dredge the meridian passage and adjusting immunologic function; Improve the intrinsic healthy energy of patient body and physical and mental health and life quality, reached the healing rehabilitation efficacy preferably.
Further specify Chinese patent medicine of the present invention to treating psoriatic effect through clinical practice below.
One, clinical diagnosis standard:
The position of morbidity is the most common with scalp, is shank, ancon, back, upper arm, forearm knee, chest and abdominal part and buttocks etc. secondly.Often be symmetry and distribute, also can distribute along tegumentary nerve is the wire arrangement.Skin lesion is from the beginning of for there being the flat pimple of polygon of assembling tendency, the normal or flushing slightly of color of the leather, and lustrous surface or be covered with poor bran skin shape squama is later on owing to constantly scratch or rub; Pimple enlarges gradually, merges in flakes mutually, and the then local skin that continues thickens, and texture is deepened; Intermesh, dry tack free is coarse, and a little canescence squama is arranged, and is lichenification; Skin lesion can rounded or irregular shape patch, clear border, and that touches is coarse.Owing to scratch, near affected part and can also can have new flat hillock rash to occur it with scratch, petechia or blood crusts on every side.Conscious paroxysmal is very itched, and is more acute during by clothing friction and sweat stain, becoming severe at night, and that scratches does not know pain.During anxious state of mind, pruritus is aggravation thereupon also.Because of pruritus can influence work and rest, the patient is often with insomnia, dizzy, irritated symptom.The primary disease course of disease is slow, and constant year does not heal, repeatedly outbreak.
How much be divided into two kinds of general hair style and topical types by its site of pathological change, skin lesion clinically.Topical type, skin lesion is detected in parts such as neck, is the minority boundary plump speckle sheet of lichen appearance clearly; General hair style, it is more extensive to distribute, and good sending out located in head, extremity, shoulder waist etc., even general whole body is everywhere, and the skin lesion characteristics are identical with topical type.
According to psoriatic clinical manifestation and pathological characters, generally be divided into following four types
1, psoriasis vulgaris: erythra generally occurs in scalp, trunk, extremity are stretched side, be red pimple on skin, to occur, and expansion are fused into patch or speckle gradually; There are thicker silvery white phosphorus bits on the surface, out-of-shape, and what have has map or an island appearance outward appearance; The skin lesion that has is less, and is more, is the Caulis et folium pavettae hongkongensis outward appearance; Squama layer one deck comes off, and wipes scurf gently off and can see the red film of very thin one deck, strikes off red film and can see slight petechia; There is person to reveal, medically makes the sieve shape hemorrhage again, homeliness type psoriasis Clinical symptoms that Here it is for blood.
2, erythrodermic psoriasis: be more serious, more rare is a kind of, and this kind of is meant and is the diffusivity redness more than 70% at about whole skin; Kermesinus wellability skin lesion, surface have a large amount of bran skin appearance scurfs, sometimes in the oxter; Thigh root and umbilical part make exfoliation and ooze out because of swelling; Oropharynx nose and eye conjunctiva can be congested rubescent, and the patient often has heating fear of cold, symptoms such as headache and general malaise.
3, pustular psoriasis: divide general property and limitation.Mostly general property pustule type psoriasis is acute onset, can be in a few days to several weeks general whole body of pustule, the intensive potential pimple of needle point size is arranged earlier; Be fused into the pus lake very soon, often with hyperpyrexia, arthralgia and general malaise, the visible leukocytosis of routine blood test chemical examination; After abscess is dry; Desquamation after scurf comes off, has new abscess to occur again immediately.Limitation pustule type psoriasis is seen with palm toe pustule type psoriasis more; With toes portion the symmetry erythema is arranged at the both hands palms, occur syringe needle on the erythema and arrive Li Daxiao greatly to pimple: about 1-2 dries up after week voluntarily, and new pustule appearance is arranged again behind the desquamation; Be continuous repeatedly, the course of disease is obstinate.
4, psoriasis arthropathica: rarely found, any age all can take place, and can betide big or small joint simultaneously, but common be the little joint of wrist, finger and toes, joint of vertebral column also can take place.The joint of pathological changes has redness, pain, serious articular cavity that hydrops is arranged, juxtra-articular skin turgor limitation of activity, joint stiffness of a specified duration; It is thus clear that the X line is down the ruined situation in joint when serious; Erythrocyte sedimentation rate is fast, General Symptomies such as the heat that often occurs together, but rheumatoid agglutinating factor is negative; How psoriasis arthropathica, skin lesion also can only have the skin lesion of homeliness type psoriasic erythema and silver bits with the ostraceous skin lesion of thick picture.
Differential Diagnosis
1. the pathogenic process of acute eczema such as chronic eczema has erubescence, pimple, vesicle, erosion more, ooze out, skin lesion is coarse with plumpness to be main, and with eruption, vesicle, erosion, ooze out, owe clearly on the border, and pathological changes is many bends side at extremity.
2. the skin amyloidosis pilosity is stretched side at back and shank, and skin is the dome pimple of sorghum rice size, and color is purple brown, and matter is harder, and is in groups intensive, and keratinization is coarse.
3. white lump skin lesion substrate is pale red, on cover with silvery white pityrosporum shape squama, thin film phenomenon and petechial hemorrhage are arranged after peelling off.
Two. case selection
All can be used as case for the patient who meets above-mentioned disease and observe, especially weak and sickly, middle-aged and elderly people, women, child are observed as first-selected case especially; The method of observing is then carried out complete observation through the method for hoping, asking, hearing, cutting to the patient; And for of all ages, the sex of the heavier patient of the state of an illness, without exception as the direct study subject of observing treatment.
Three. administrated method
According to psoriatic's severe extent, the length of sick time, treat psoriasis with oral Chinese patent medicine of the present invention in adopting, its method of administration is: three times on the one, each 6-12 gram, warm water delivery service; Ante cibum, one after each meal all can.Just the clothes phase is 30 days, and dose can increase doubly, after this takes medicine continuously by conventional dose, and three months is to observe with curative effect a course of treatment to judge.Chinese patent medicine of the present invention has no side effect through clinical application toxicity test proof because of Chinese medicine preparation, reasonable recipe, and therefore, but the patient takes Chinese patent medicine of the present invention the long period during treating, and need not dieting aspect the period in a medicine diet.
Four. curative effect determinate standard
Because psoriasis is the dermatosis that is prone to examine refractory, thereby psoriatic clinical treatment observation index and curative effect judging standard are divided into: during the treatment, treatment finishes the back and visit long term in three periods.
1. treat phase clinical observation and curative effect judging standard
(1) clinical observation
1. squama: the propagation of epidermis cell is quickened and hyperacanthosis, causes cuticular hyperkeratosis, makes epidermis renew the normal fast 7-8 of epidermis of rate doubly, promptly per 3 days left and right sides desquamation one decks.Criterion after the medication is: squama reduces gradually or does not have new skin lesion and appears as effectively, otherwise is invalid.
2. substrate: it shows as substrate infiltration, plumpness, shows that the stratum germinativum increment of chrotoplast slows down, and hyperacanthosis fades, and the substrate skin lesion explain effectively, and the nothing change is soaked in substrate by thick attenuation, plump no attenuation, and it is invalid then to explain.
3. color: because the expansion of corium superficial part vascular plexus and blood capillary, its skin lesion has the non-fading red appearance of pressure more.After the medication, along with the alleviation of the state of an illness, the color of erythra is light red by red stain also, explains effectively, otherwise is invalid.
4. scope: skin lesion many and few indicate the light and heavy of the state of an illness.After the medication, new skin lesion stops to occur, and original erythra begins to dwindle from the edge, or therefrom the mind-set edge disappears gradually, and the erythra that part is big is divided into plurality of small blocks, explain effectively, on the contrary then invalid.
(2) curative effect judging standard:
1. produce effects: in above four, there are three to be clearly better, or four improvement that all have in various degree; Or binomial disappears binomial improvement in addition.
2. effective: as to have binomial to improve or a disappearance.
3. invalid: through one course of treatment of clinical application, skin lesion does not have and improves or increase the weight of.
2. treatment finishes back clinical observation and curative effect judging standard
(1) clinical observation:
1. whether squama: observing has new squama to occur.
2. substrate: whether erythra calms down, the smoothness of skin.
3. color: observe and have or not pigmentation or depigmentation.
4. whether scope: observing has new erythra to occur and the situation that disappears of former skin lesion.
(2) curative effect judging standard:
1. clinical cure: skin lesion all disappears, and only leaves pigmentation or takes off mistake.
2. produce effects: skin lesion disappears more than 70%.
3. effective: skin lesion disappears between the 30-70%.
4. invalid: skin lesion disappears below 30% or is not increased the weight of on the contrary by control.
3. visit clinical observation and curative effect judging standard long term
(1) clinical observation:
1. time: treatment finishes back more than 1 year or 2～three years, visits recovery from illness and recurrence situation.
2. case: visit case and cause of recurrence that observation post cures.
(2) curative effect judging standard:
1. recurrence: the skin lesion area is than enlarging before treating or increasing the weight of.
2. gently recurrence: the recurrence skin lesion is below 50% of former skin lesion.
Five. the clinical treatment result
Chinese patent medicine of the present invention carries out orally taken for curing through all kinds of psoriatics 296 examples that 2005-2010 is accepted for medical treatment in 4 years altogether, male's 146 examples wherein, and women's 150 examples, the age is 16-55 year; Its clinical treatment result according to above-mentioned domestic unified criterion of therapeutical effect statistical computation is: recovery from illness (drug withdrawal observe more than 3 years not recidivist) 117 examples, and cure rate is 39.53%; Produce effects (drug withdrawal observe more than 1 year not recidivist) 106 examples, obvious effective rate is 35.81%; Effective (symptom obviously alleviates the scurf major part and comes off, and still has the few part silver bits person of not moving back) 55 examples, effective percentage is 18.58%; Invalid (take medicine 2 courses of treatment not alleviator) 18 examples, inefficiency 6.08%; Total effective rate is 93.92%, and not seeing has any toxic and side effects.
Model case is introduced:
1, Li Changfa, the man, 45 years old, live Zhifu District pearl village, Yantai City taxi driver, on January 16th, 2008 went to a doctor in the applicant's out-patient department, according to ill 6 years of patient's readme, repeatedly went to see a doctor, and did not all have positive effect and did not cure so far.Through taking Chinese patent medicine of the present invention after course of treatment, the disease significant effective, after this continuous use is promptly fully recovered 6 courses of treatment.Treatment finishes the back not recurrence of visiting more than 2 years.
2, Feng Shaojun, man, 52 years old; Live Chi Shan town, flourish city, the teacher suffered from psoriasis nearly 20 years; Be illustrated in through others and went to a doctor on March 12nd, 2005, repeatedly gone to see a doctor the folk prescription of also using others to give since patient's readme is ill in the applicant's out-patient department; Bad during fashion, all do not have positive effect and do not cure so far.Take Chinese patent medicine of the present invention after diagnosing after course of treatment, disease is not seen positive effect, but sensation effectively; Patient after this 3 course of treatment sides of continuous use sees obvious curative effects; Continuing to take Chinese patent medicine of the present invention promptly fully recovers 8 courses of treatment.After finishing, treatment visited not recurrence so far more than 5 years.
3, Yu Aijuan, the woman 40 years old, lives Wang Tuan town, Wendeng City; The worker suffered from psoriasis nearly 10 years, was illustrated in through others and went to a doctor in the applicant's out-patient department on May 18th, 2009, and the patient has repeatedly gone to see a doctor since ill; The folk prescription of also using others to give, bad during fashion, but do not cure so far.Take Chinese patent medicine of the present invention after diagnosing after course of treatment, the visible positive effect of disease; Patient after this continuous use promptly fully recovers 6 courses of treatment.After finishing, treatment visited not recurrence so far more than 1 year.
The specific embodiment
Embodiment 1
The described Chinese patent medicine of present embodiment is as the psoriatic endo-medicine of treatment, is to press the row weight portion to take by weighing each Chinese crude drug: 15 parts of Cortex Moutans, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts in the Radix Rehmanniae, 15 parts in Poria, 15 parts of Fructus Leonuris, 10 parts of Herba Schizonepetae (parched), 15 parts of Radix Isatidis, 15 parts of Flos Loniceraes, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Cortex Dictamnis, 15 parts of Rhizoma Curcumae, 10 parts on Flos Carthami, 30 parts of Fructus Mumes, 60 parts of Concha Ostreae (calcined)s, 15 parts of Radix Paeoniae Rubra, 5 parts in Radix Glycyrrhizae.
The preparation technology of present embodiment is: above-mentioned each medicinal raw material is processed sublimed preparation according to the pharmaceutical methods that routine prepares sublimed preparation.
Embodiment 2
Press the row weight portion and take by weighing each medical material: 45 parts of Cortex Moutans, 50 parts of Radix Salviae Miltiorrhizaes, 45 parts in the Radix Rehmanniae, 45 parts in Poria, 45 parts of Fructus Leonuris, 40 parts of Herba Schizonepetae (parched), 45 parts of Radix Isatidis, 45 parts of Flos Loniceraes, 45 parts of Radix Arnebiae (Radix Lithospermi)s, 45 parts of Cortex Dictamnis, 45 parts of Rhizoma Curcumae, 30 parts on Flos Carthami, 70 parts of Fructus Mumes, 90 parts of Concha Ostreae (calcined)s, 45 parts of Radix Paeoniae Rubra, 35 parts in Radix Glycyrrhizae.
The described Chinese patent medicine of present embodiment is that its preparation technology is: above-mentioned each medicinal raw material is processed packed powder according to the pharmaceutical methods that routine prepares powder as the psoriatic endo-medicine of treatment.
Embodiment 3
Press the row weight portion and take by weighing each medical material: 25 parts of Cortex Moutans, 30 parts of Radix Salviae Miltiorrhizaes, 25 parts in the Radix Rehmanniae, 25 parts in Poria, 25 parts of Fructus Leonuris, 20 parts of Herba Schizonepetae (parched), 25 parts of Radix Isatidis, 25 parts of Flos Loniceraes, 25 parts of Radix Arnebiae (Radix Lithospermi)s, 25 parts of Cortex Dictamnis, 25 parts of Rhizoma Curcumae, 15 parts on Flos Carthami, 40 parts of Fructus Mumes, 70 parts of Concha Ostreae (calcined)s, 25 parts of Radix Paeoniae Rubra, 10 parts in Radix Glycyrrhizae.
The described Chinese patent medicine of present embodiment is that its preparation technology is: above-mentioned each medicinal raw material is processed capsule according to the pharmaceutical methods that routine prepares capsule as the psoriatic endo-medicine of treatment.
Embodiment 4
Press the row weight portion and take by weighing each medical material: Cortex Moutan 25-35 part, Radix Salviae Miltiorrhizae 30-40 part, Radix Rehmanniae 25-35 part, Poria 25-35 part, Fructus Leonuri 25-35 part, Herba Schizonepetae (parched) 20-30 part, Radix Isatidis 25-35 part, Flos Lonicerae 25-35 part, Radix Arnebiae (Radix Lithospermi) 25-35 part, Cortex Dictamni 25-35 part, Rhizoma Curcumae 25-35 part, Flos Carthami 15-25 part, Fructus Mume 40-60 part, Concha Ostreae (calcined) 70-80 part, Radix Paeoniae Rubra 25-35 part, Radix Glycyrrhizae 10-30 part.
The described Chinese patent medicine of present embodiment is as the psoriatic endo-medicine of treatment; Its preparation technology is: above-mentioned each medicinal raw material is processed tablet according to the pharmaceutical methods that routine prepares tablet; (like conventional tablet, sugar coated tablet, film coated tablet etc.), and give conventional drug excipient (like starch, sucrose, lactose, calcium stearate, magnesium stearate etc.).
Embodiment 5
Press the row weight portion and take by weighing each medical material: 30 parts of Cortex Moutans, 35 parts of Radix Salviae Miltiorrhizaes, 30 parts in the Radix Rehmanniae, 30 parts in Poria, 30 parts of Fructus Leonuris, 25 parts of Herba Schizonepetae (parched), 30 parts of Radix Isatidis, 30 parts of Flos Loniceraes, 30 parts of Radix Arnebiae (Radix Lithospermi)s, 30 parts of Cortex Dictamnis, 30 parts of Rhizoma Curcumae, 20 parts on Flos Carthami, 50 parts of Fructus Mumes, 75 parts of Concha Ostreae (calcined)s, 30 parts of Radix Paeoniae Rubra, 20 parts in Radix Glycyrrhizae.
The described Chinese patent medicine of present embodiment is that its preparation technology is as the psoriatic endo-medicine of treatment: above-mentioned each medicinal raw material is processed pill according to the pharmaceutical methods that routine prepares pill, and give conventional drug excipient.
Embodiment 6
Press the row weight portion and take by weighing each medical material: 30 parts of Cortex Moutans, 35 parts of Radix Salviae Miltiorrhizaes, 30 parts in the Radix Rehmanniae, 30 parts in Poria, 30 parts of Fructus Leonuris, 25 parts of Herba Schizonepetae (parched), 30 parts of Radix Isatidis, 30 parts of Flos Loniceraes, 30 parts of Radix Arnebiae (Radix Lithospermi)s, 30 parts of Cortex Dictamnis, 30 parts of Rhizoma Curcumae, 20 parts on Flos Carthami, 50 parts of Fructus Mumes, 75 parts of Concha Ostreae (calcined)s, 30 parts of Radix Paeoniae Rubra, 20 parts in Radix Glycyrrhizae.
The described Chinese patent medicine of present embodiment is that its preparation technology is: above-mentioned each medicinal raw material is processed granule according to the pharmaceutical methods that routine prepares granule as the psoriatic endo-medicine of treatment.
Claims (6)
1. the psoriatic Chinese patent medicine of treatment is characterized in that being prepared from following medicaments in part by weight: Cortex Moutan 15-45 part, Radix Salviae Miltiorrhizae 20-50 part, Radix Rehmanniae 15-45 part, Poria 15-45 part, Fructus Leonuri 15-45 part, Herba Schizonepetae (parched) 10-40 part, Radix Isatidis 15-45 part, Flos Lonicerae 15-45 part, Radix Arnebiae (Radix Lithospermi) 15-45 part, Cortex Dictamni 15-45 part, Rhizoma Curcumae 15-45 part, Flos Carthami 10-30 part, Fructus Mume 30-70 part, Concha Ostreae (calcined) 60-90 part, Radix Paeoniae Rubra 15-45 part, Radix Glycyrrhizae 5-35 part.
2. the psoriatic Chinese patent medicine of treatment according to claim 1 is characterized in that being prepared from following medicaments in part by weight: Cortex Moutan 25-35 part, Radix Salviae Miltiorrhizae 30-40 part, Radix Rehmanniae 25-35 part, Poria 25-35 part, Fructus Leonuri 25-35 part, Herba Schizonepetae (parched) 20-30 part, Radix Isatidis 25-35 part, Flos Lonicerae 25-35 part, Radix Arnebiae (Radix Lithospermi) 25-35 part, Cortex Dictamni 25-35 part, Rhizoma Curcumae 25-35 part, Flos Carthami 15-25 part, Fructus Mume 40-60 part, Concha Ostreae (calcined) 70-80 part, Radix Paeoniae Rubra 25-35 part, Radix Glycyrrhizae 10-30 part.
3. the psoriatic Chinese patent medicine of treatment according to claim 1 is characterized in that being prepared from following medicaments in part by weight: 30 parts of Cortex Moutans, 35 parts of Radix Salviae Miltiorrhizaes, 30 parts in the Radix Rehmanniae, 30 parts in Poria, 30 parts of Fructus Leonuris, 25 parts of Herba Schizonepetae (parched), 30 parts of Radix Isatidis, 30 parts of Flos Loniceraes, 30 parts of Radix Arnebiae (Radix Lithospermi)s, 30 parts of Cortex Dictamnis, 30 parts of Rhizoma Curcumae, 20 parts on Flos Carthami, 50 parts of Fructus Mumes, 75 parts of Concha Ostreae (calcined)s, 30 parts of Radix Paeoniae Rubra, 20 parts in Radix Glycyrrhizae.
4. according to the psoriatic Chinese patent medicine of the described treatment of the arbitrary claim of claim 1 to 3, it is characterized in that described Chinese patent medicine processes pill, sublimed preparation, powder, tablet, unguentum, decoction and the different oral medicine dosage form of capsule dress powder according to the conventional technology of preparing of Chinese medicine.
5. the psoriatic Chinese patent medicine of treatment according to claim 4 is characterized in that described Chinese patent medicine also contains drug excipient.
6. the psoriatic Chinese patent medicine of the described treatment of the arbitrary claim of claim 1-3 is characterized in that the application of described Chinese patent medicine as treatment psoriasis disease.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011103762963A CN102406893A (en) | 2011-11-16 | 2011-11-16 | Chinese patent medicine for treating psoriasis. |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011103762963A CN102406893A (en) | 2011-11-16 | 2011-11-16 | Chinese patent medicine for treating psoriasis. |
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