CN103860773A - Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof Download PDFInfo
- Publication number
- CN103860773A CN103860773A CN201410144523.3A CN201410144523A CN103860773A CN 103860773 A CN103860773 A CN 103860773A CN 201410144523 A CN201410144523 A CN 201410144523A CN 103860773 A CN103860773 A CN 103860773A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- radix
- weight
- chinese medicine
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 68
- 239000000203 mixture Substances 0.000 title claims abstract description 55
- 208000003067 Myocardial Ischemia Diseases 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 210000000582 Semen Anatomy 0.000 claims abstract description 31
- 241000222336 Ganoderma Species 0.000 claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 38
- 239000000463 material Substances 0.000 claims description 37
- 241000628997 Flos Species 0.000 claims description 31
- 241000601090 Equisetum pratense Species 0.000 claims description 22
- 239000000341 volatile oil Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000000706 filtrate Substances 0.000 claims description 16
- 239000002775 capsule Substances 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 9
- 229940023488 Pill Drugs 0.000 claims description 8
- 238000009835 boiling Methods 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 239000006187 pill Substances 0.000 claims description 8
- 239000002244 precipitate Substances 0.000 claims description 8
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 8
- 239000008158 vegetable oil Substances 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 7
- 239000002552 dosage form Substances 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- 238000007792 addition Methods 0.000 claims description 4
- 239000000084 colloidal system Substances 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 4
- 238000000703 high-speed centrifugation Methods 0.000 claims description 4
- 239000012567 medical material Substances 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 235000011837 pasties Nutrition 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- -1 soak 0.5-1.5 hour Substances 0.000 claims description 4
- 238000001256 steam distillation Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 238000000194 supercritical-fluid extraction Methods 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 238000000108 ultra-filtration Methods 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 2
- 210000004369 Blood Anatomy 0.000 abstract description 51
- 239000008280 blood Substances 0.000 abstract description 51
- 208000002193 Pain Diseases 0.000 abstract description 28
- 230000036407 pain Effects 0.000 abstract description 28
- 230000000694 effects Effects 0.000 abstract description 22
- 230000017531 blood circulation Effects 0.000 abstract description 18
- 230000001737 promoting Effects 0.000 abstract description 13
- 231100000331 toxic Toxicity 0.000 abstract description 6
- 230000004087 circulation Effects 0.000 abstract description 5
- 231100000486 side effect Toxicity 0.000 abstract description 4
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 235000016855 Biancospino Nutrition 0.000 abstract 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 abstract 1
- 235000004423 Crataegus monogyna Nutrition 0.000 abstract 1
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 240000001211 Equisetum Species 0.000 abstract 1
- 241001189830 Fissistigma Species 0.000 abstract 1
- 240000005389 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 235000003365 Ilex pubescens Nutrition 0.000 abstract 1
- 241001100932 Ilex pubescens Species 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 235000016247 Mentha requienii Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 240000008259 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 244000274050 Platycodon grandiflorum Species 0.000 abstract 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 241000270666 Testudines Species 0.000 abstract 1
- 235000006682 bigleaf mint Nutrition 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 235000002313 hawthorn Nutrition 0.000 abstract 1
- 235000009444 hawthorn Nutrition 0.000 abstract 1
- 235000009486 hawthorn Nutrition 0.000 abstract 1
- 235000009682 hawthorn Nutrition 0.000 abstract 1
- 235000009685 hawthorn Nutrition 0.000 abstract 1
- 235000009917 hawthorn Nutrition 0.000 abstract 1
- 235000013161 hawthorn Nutrition 0.000 abstract 1
- 235000013165 hawthorn Nutrition 0.000 abstract 1
- 235000013189 hawthorn Nutrition 0.000 abstract 1
- 235000013204 hawthorn Nutrition 0.000 abstract 1
- 235000013214 hawthorn Nutrition 0.000 abstract 1
- 235000013246 hawthorn Nutrition 0.000 abstract 1
- 235000017423 hawthorn Nutrition 0.000 abstract 1
- 239000006049 herbal material Substances 0.000 abstract 1
- 235000014063 licorice root Nutrition 0.000 abstract 1
- 235000006679 mint Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 16
- 210000002216 Heart Anatomy 0.000 description 12
- 210000001015 Abdomen Anatomy 0.000 description 11
- 210000000952 Spleen Anatomy 0.000 description 10
- 210000004072 Lung Anatomy 0.000 description 9
- 210000002784 Stomach Anatomy 0.000 description 9
- 206010002383 Angina pectoris Diseases 0.000 description 8
- 206010062717 Increased upper airway secretion Diseases 0.000 description 8
- 210000004185 Liver Anatomy 0.000 description 8
- 210000000214 Mouth Anatomy 0.000 description 8
- 210000000038 chest Anatomy 0.000 description 8
- 239000007789 gas Substances 0.000 description 8
- 230000002401 inhibitory effect Effects 0.000 description 8
- 206010000087 Abdominal pain upper Diseases 0.000 description 7
- 206010001928 Amenorrhoea Diseases 0.000 description 7
- 231100000614 Poison Toxicity 0.000 description 7
- 201000000736 amenorrhea Diseases 0.000 description 7
- 231100000540 amenorrhea Toxicity 0.000 description 7
- 230000036772 blood pressure Effects 0.000 description 7
- 230000001717 pathogenic Effects 0.000 description 7
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 6
- 206010022114 Injury Diseases 0.000 description 6
- 210000003734 Kidney Anatomy 0.000 description 6
- 210000003205 Muscles Anatomy 0.000 description 6
- 230000035876 healing Effects 0.000 description 6
- 230000001077 hypotensive Effects 0.000 description 6
- 230000000414 obstructive Effects 0.000 description 6
- 239000003440 toxic substance Substances 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 206010013935 Dysmenorrhoea Diseases 0.000 description 5
- 208000000059 Dyspnea Diseases 0.000 description 5
- 206010013975 Dyspnoeas Diseases 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- 208000004880 Polyuria Diseases 0.000 description 5
- 230000003110 anti-inflammatory Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 230000035619 diuresis Effects 0.000 description 5
- 230000003203 everyday Effects 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 210000000056 organs Anatomy 0.000 description 5
- 244000052769 pathogens Species 0.000 description 5
- 230000025627 positive regulation of urine volume Effects 0.000 description 5
- 230000001225 therapeutic Effects 0.000 description 5
- 238000010792 warming Methods 0.000 description 5
- 208000006673 Asthma Diseases 0.000 description 4
- 210000000481 Breast Anatomy 0.000 description 4
- 206010008479 Chest pain Diseases 0.000 description 4
- 208000005171 Dysmenorrhea Diseases 0.000 description 4
- 206010019233 Headache Diseases 0.000 description 4
- 210000004165 Myocardium Anatomy 0.000 description 4
- 210000003491 Skin Anatomy 0.000 description 4
- 206010042674 Swelling Diseases 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 4
- 230000003042 antagnostic Effects 0.000 description 4
- 231100000869 headache Toxicity 0.000 description 4
- NTYJJOPFIAHURM-UHFFFAOYSA-N histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000002522 swelling Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 231100000820 toxicity test Toxicity 0.000 description 4
- 208000004998 Abdominal Pain Diseases 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- 229940107161 Cholesterol Drugs 0.000 description 3
- 241000668709 Dipterocarpus costatus Species 0.000 description 3
- 208000001848 Dysentery Diseases 0.000 description 3
- 208000005679 Eczema Diseases 0.000 description 3
- 208000008454 Hyperhidrosis Diseases 0.000 description 3
- 206010025482 Malaise Diseases 0.000 description 3
- 210000004379 Membranes Anatomy 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 210000003800 Pharynx Anatomy 0.000 description 3
- 206010036790 Productive cough Diseases 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 206010037844 Rash Diseases 0.000 description 3
- 210000003802 Sputum Anatomy 0.000 description 3
- 206010042772 Syncope Diseases 0.000 description 3
- 241000130764 Tinea Species 0.000 description 3
- 208000002474 Tinea Diseases 0.000 description 3
- 210000003932 Urinary Bladder Anatomy 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 230000003213 activating Effects 0.000 description 3
- 230000000202 analgesic Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 201000004624 dermatitis Diseases 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 229940079593 drugs Drugs 0.000 description 3
- 231100001003 eczema Toxicity 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 230000002269 spontaneous Effects 0.000 description 3
- 230000035900 sweating Effects 0.000 description 3
- 201000010874 syndrome Diseases 0.000 description 3
- 230000002588 toxic Effects 0.000 description 3
- 200000000019 wound Diseases 0.000 description 3
- JWZZKOKVBUJMES-UHFFFAOYSA-N 4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 2
- 206010003119 Arrhythmia Diseases 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 2
- 206010003211 Arteriosclerosis coronary artery Diseases 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- 206010003246 Arthritis Diseases 0.000 description 2
- 210000004204 Blood Vessels Anatomy 0.000 description 2
- 210000000988 Bone and Bones Anatomy 0.000 description 2
- 240000000218 Cannabis sativa Species 0.000 description 2
- 206010007521 Cardiac arrhythmias Diseases 0.000 description 2
- 208000002881 Colic Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 210000004351 Coronary Vessels Anatomy 0.000 description 2
- 206010013990 Dysuria Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 229940088598 Enzyme Drugs 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- 206010018913 Haemolysis Diseases 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- 206010019909 Hernia Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 229940039009 Isoproterenol Drugs 0.000 description 2
- 208000010125 Myocardial Infarction Diseases 0.000 description 2
- 210000004915 Pus Anatomy 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 241000405911 Rehmannia glutinosa Species 0.000 description 2
- 206010072736 Rheumatic disease Diseases 0.000 description 2
- 206010040872 Skin infection Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- QMGVPVSNSZLJIA-FVWCLLPLSA-N Strychnine Chemical compound O([C@H]1CC(N([C@H]2[C@H]1[C@H]1C3)C=4C5=CC=CC=4)=O)CC=C1CN1[C@@H]3[C@]25CC1 QMGVPVSNSZLJIA-FVWCLLPLSA-N 0.000 description 2
- 206010043540 Thromboangiitis obliterans Diseases 0.000 description 2
- 208000004371 Toothache Diseases 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 239000006286 aqueous extract Substances 0.000 description 2
- 230000001174 ascending Effects 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000009465 diaoxinxuekang Substances 0.000 description 2
- 201000008286 diarrhea Diseases 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 230000002708 enhancing Effects 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 230000003419 expectorant Effects 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000004634 feeding behavior Effects 0.000 description 2
- 235000021285 flavonoid Nutrition 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 229930003935 flavonoids Natural products 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 239000008899 fufang danshen Substances 0.000 description 2
- 235000019525 fullness Nutrition 0.000 description 2
- 230000002496 gastric Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- 230000001146 hypoxic Effects 0.000 description 2
- 230000001976 improved Effects 0.000 description 2
- 230000001965 increased Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 229960001317 isoprenaline Drugs 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 230000000552 rheumatic Effects 0.000 description 2
- 230000000630 rising Effects 0.000 description 2
- 230000007958 sleep Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- JLTCWSBVQSZVLT-CDIPANDDSA-N (2S)-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosan Chemical compound NCCCC[C@@H](C(=O)NCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](N)CSSC1.C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 JLTCWSBVQSZVLT-CDIPANDDSA-N 0.000 description 1
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000269 Abscess Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 229960004373 Acetylcholine Drugs 0.000 description 1
- 210000004404 Adrenal Cortex Anatomy 0.000 description 1
- 206010001897 Alzheimer's disease Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010065558 Aortic arteriosclerosis Diseases 0.000 description 1
- 210000001367 Arteries Anatomy 0.000 description 1
- 206010003549 Asthenia Diseases 0.000 description 1
- 206010003693 Atrophic vulvovaginitis Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 208000006218 Bradycardia Diseases 0.000 description 1
- 241000208671 Campanulaceae Species 0.000 description 1
- 206010007554 Cardiac failure Diseases 0.000 description 1
- 208000008787 Cardiovascular Disease Diseases 0.000 description 1
- 210000001168 Carotid Artery, Common Anatomy 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 208000003569 Central Serous Chorioretinopathy Diseases 0.000 description 1
- 206010008132 Cerebral thrombosis Diseases 0.000 description 1
- 208000010445 Chilblains Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 208000002573 Connective Tissue Disease Diseases 0.000 description 1
- 208000006111 Contracture Diseases 0.000 description 1
- 208000008313 Contusions Diseases 0.000 description 1
- 206010010970 Cor pulmonale chronic Diseases 0.000 description 1
- 241000657528 Dalbergia odorifera Species 0.000 description 1
- 206010057315 Daydreaming Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N Dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 229960003957 Dexamethasone Drugs 0.000 description 1
- 206010012601 Diabetes mellitus Diseases 0.000 description 1
- 208000000718 Duodenal Ulcer Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 208000001780 Epistaxis Diseases 0.000 description 1
- 210000003608 Feces Anatomy 0.000 description 1
- 206010016322 Feeling abnormal Diseases 0.000 description 1
- 206010055690 Foetal death Diseases 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 210000000232 Gallbladder Anatomy 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 210000001156 Gastric Mucosa Anatomy 0.000 description 1
- 210000001035 Gastrointestinal Tract Anatomy 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 206010018830 Haematemesis Diseases 0.000 description 1
- 206010018836 Haematochezia Diseases 0.000 description 1
- 206010019280 Heart failure Diseases 0.000 description 1
- 206010020039 Hiccups Diseases 0.000 description 1
- 210000001624 Hip Anatomy 0.000 description 1
- 208000006572 Human Influenza Diseases 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 206010062060 Hyperlipidaemia Diseases 0.000 description 1
- 210000003026 Hypopharynx Anatomy 0.000 description 1
- 206010021079 Hypopnoea Diseases 0.000 description 1
- 206010022000 Influenza Diseases 0.000 description 1
- 206010022437 Insomnia Diseases 0.000 description 1
- 210000000936 Intestines Anatomy 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 210000001503 Joints Anatomy 0.000 description 1
- 201000007313 Kawasaki disease Diseases 0.000 description 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 210000002540 Macrophages Anatomy 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N Malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- MDZKJHQSJHYOHJ-LLICELPBSA-N Maslinic acid Chemical compound C1[C@@H](O)[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MDZKJHQSJHYOHJ-LLICELPBSA-N 0.000 description 1
- 206010027327 Menstrual disease Diseases 0.000 description 1
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 description 1
- 230000036740 Metabolism Effects 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010027599 Migraine Diseases 0.000 description 1
- 208000008085 Migraine Disorders Diseases 0.000 description 1
- 208000001725 Mucocutaneous Lymph Node Syndrome Diseases 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 210000002464 Muscle, Smooth, Vascular Anatomy 0.000 description 1
- 208000004296 Neuralgia Diseases 0.000 description 1
- NCYVXEGFNDZQCU-UHFFFAOYSA-N Nikethamide Chemical compound CCN(CC)C(=O)C1=CC=CN=C1 NCYVXEGFNDZQCU-UHFFFAOYSA-N 0.000 description 1
- 229960003226 Nikethamide Drugs 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 235000019082 Osmanthus Nutrition 0.000 description 1
- 241000333181 Osmanthus Species 0.000 description 1
- 210000004681 Ovum Anatomy 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 241000590428 Panacea Species 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 229960002275 Pentobarbital Sodium Drugs 0.000 description 1
- 210000003516 Pericardium Anatomy 0.000 description 1
- 206010034568 Peripheral coldness Diseases 0.000 description 1
- 210000004303 Peritoneum Anatomy 0.000 description 1
- 210000002381 Plasma Anatomy 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 210000000664 Rectum Anatomy 0.000 description 1
- 206010062104 Renal mass Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000005687 Scabies Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 210000001562 Sternum Anatomy 0.000 description 1
- 206010042220 Stress ulcer Diseases 0.000 description 1
- 241001279009 Strychnos toxifera Species 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 208000006379 Syphilis Diseases 0.000 description 1
- 206010043087 Tachyphylaxis Diseases 0.000 description 1
- 210000002435 Tendons Anatomy 0.000 description 1
- 208000001435 Thromboembolism Diseases 0.000 description 1
- 206010044008 Tonsillitis Diseases 0.000 description 1
- 231100000765 Toxin Toxicity 0.000 description 1
- 241001045770 Trichophyton mentagrophytes Species 0.000 description 1
- 210000001113 Umbilicus Anatomy 0.000 description 1
- 210000002700 Urine Anatomy 0.000 description 1
- 210000004291 Uterus Anatomy 0.000 description 1
- 210000001215 Vagina Anatomy 0.000 description 1
- 210000003462 Veins Anatomy 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 240000008549 Vitex agnus castus Species 0.000 description 1
- 235000001667 Vitex agnus castus Nutrition 0.000 description 1
- 210000003905 Vulva Anatomy 0.000 description 1
- 230000003187 abdominal Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000001154 acute Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 201000004484 acute conjunctivitis Diseases 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 230000001800 adrenalinergic Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000954 anitussive Effects 0.000 description 1
- 230000000507 anthelmentic Effects 0.000 description 1
- 230000003712 anti-aging Effects 0.000 description 1
- 230000003266 anti-allergic Effects 0.000 description 1
- 230000000844 anti-bacterial Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000001716 anti-fugal Effects 0.000 description 1
- 230000001139 anti-pruritic Effects 0.000 description 1
- 230000001754 anti-pyretic Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 201000001962 aortic atherosclerosis Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 201000001320 atherosclerosis Diseases 0.000 description 1
- 230000036471 bradycardia Effects 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 201000001084 cerebrovascular disease Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 201000004904 chronic pulmonary heart disease Diseases 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 230000001427 coherent Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001186 cumulative Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000378 dietary Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000000916 dilatatory Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 235000021271 drinking Nutrition 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 229910052602 gypsum Inorganic materials 0.000 description 1
- 239000010440 gypsum Substances 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000001951 hemoperfusion Effects 0.000 description 1
- 230000002607 hemopoietic Effects 0.000 description 1
- 230000002443 hepatoprotective Effects 0.000 description 1
- 230000001709 ictal Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000000968 intestinal Effects 0.000 description 1
- 201000001429 intracranial thrombosis Diseases 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 230000000622 irritating Effects 0.000 description 1
- 230000002147 killing Effects 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 230000002366 lipolytic Effects 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 229940099690 malic acid Drugs 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 230000003211 malignant Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000002175 menstrual Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000035786 metabolism Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000002107 myocardial Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 210000004493 neutrocyte Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N p-acetaminophenol Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 230000000242 pagocytic Effects 0.000 description 1
- 201000008125 pain agnosia Diseases 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 244000045947 parasites Species 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 230000001575 pathological Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000001817 pituitary Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- NIFIFKQPDTWWGU-UHFFFAOYSA-N pyrite Chemical class [Fe+2].[S-][S-] NIFIFKQPDTWWGU-UHFFFAOYSA-N 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000002829 reduced Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000003014 reinforcing Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 230000035812 respiration Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001568 sexual Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 230000000391 smoking Effects 0.000 description 1
- QGMRQYFBGABWDR-OGFXRTJISA-M sodium;5-ethyl-5-[(2R)-pentan-2-yl]pyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CCC[C@@H](C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-OGFXRTJISA-M 0.000 description 1
- 230000002048 spasmolytic Effects 0.000 description 1
- 230000021595 spermatogenesis Effects 0.000 description 1
- 230000001954 sterilising Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 229960005453 strychnine Drugs 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
- 230000003313 weakening Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Abstract
The invention discloses a traditional Chinese medicine composition for treating myocardial ischemia and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw herbal materials: angelica sinensis, radix rehmanniae recen, radix sophorae flavescentis, flowers carthami, root of kudzu vine, root of common peony, mint, honey-fried licorice root, platycodon grandiflorum, ligusticum wallichii, equisetum pretense, lignum dalbergiae odoriferae, pubescent holly root, turtle feet, cortex cinnamomi, lucid ganoderma, fissistigma bracteolatum, semen lepidii, agilawood, fructus piperis longi and hawthorn. The traditional Chinese medicine composition has the beneficial effects that the traditional Chinese medicine composition disclosed by the invention has the effects of promoting blood circulation to remove blood stasis, and promoting coronary circulation and relieving pain, and has the advantages of being good in treatment effect, short in treatment course, not easy to reappear and small in toxic and side effects on treatment of myocardial ischemia.
Description
Technical field
The present invention relates to derive from the medicinal preparation of plant, animal or raw mineral materials, particularly a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia and preparation method thereof.
Background technology
Myocardial ischemia, refers to that the hemoperfusion of heart reduces, and causes the oxygen supply of heart to reduce, and energy metabolism of myocardial is undesired, can not support a kind of pathological state of the normal work of heart.Have a strong impact on people's live and work, severe patient can cause myocardial infarction and sudden death.The health of myocardial ischemia serious harm middle-aged and elderly people, in recent years along with growth in the living standard, coronary atherosclerosis presents the trend of rejuvenation, and also there is the performance of myocardial ischemia in the youngster in some 20-30 years.
Myocardial ischemia reduces heart blood, and blood is to transmit the necessary material of blood, if lack blood, can cause anoxia, thereby cause heart not provide necessary energy for activity, can cause angina pectoris, cardiac function decline, arrhythmia etc.The common reason of myocardial ischemia is coronary atherosclerosis, secondly also has inflammation (rheumatic, syphilis, mucocutaneous lymphnode syndrome and thromboangitis obliterans etc.), spasm, thromboembolism, connective tissue disease, wound and congenital malformation etc. multiple.Epidemiological study finds, the significant risk factor relevant to atherosclerosis is that hyperlipemia, hypertension, diabetes, smoking, obesity, homocysteine increase, physical exertion is few, advanced age and male etc.Myocardial ischemia mostly occurred after 40 years old, and average prevalence is about 6.49%.Along with the raising of living standards of the people, myocardial ischemia is the trend rising year by year in the prevalence of China at present.Myocardial ischemia is commonly encountered diseases and the frequently-occurring disease of middle-aged and elderly people, often shows as: after there is breastbone when fatigue or psychentonia or precordial fullness pain, or tighten sample pain, and shoulder, left upper arm radiation left, continue 3-5 minutes, have a rest after spontaneous remission person, time with profuse sweating; When physical exertion, there is uncomfortable in chest, cardiopalmus, breathe hard, spontaneous remission person when rest; There is the throat pain relevant with motion and burn feeling, constriction, toothache etc.; Heavy meal, cold, there is chest pain, person uncomfortable in chest after drinking; When night, sleep pillow was low, feel chest distress, need high pillow clinostatism side to feel comfortable person; Sleep soundly or unexpected chest pain, cardiopalmus, dyspnea when daytime is flat sleeping, need sit up immediately or stand can alleviation person; When sexual life or firmly defecation, occur nervous, uncomfortable in chest, out of breath or chest pain is uncomfortable; Bradycardia, Blood pressure drop or the person of fainting of burst.
Myocardial ischemia belongs to motherland's medical science " thoracic obstruction ", " cardiopalmus " category.Chinese medicine thinks, obstruction of qi in the chest and cardialgia is due to healthy energy virtual loss, caused, the blood stasis turbid with expectorant such as diet, feelings will, cold-evil, the stagnation of QI, cold coagulation numbness resistance heart arteries and veins, taking Danzhong or left chest ictally feel oppressed, pain is as mainly facing a kind of disease of performance.The lighter accidental of short duration slight chest oppressiveness or dull pain, or be ictal Danzhong or the unclean sense of discomfort of left breast; Severe one sharp ache, or be squeezing sample angor.Often, with cardiopalmus, breathe hard, hypopnea, even dyspnea with rapid and short breath, uneasy in terror, pale complexion, cold spontaneous sweating etc.How by fatigue, heavy meal, cold and excited and bring out, also can be without obvious inducement or morbidity when quiet.
Obstruction of qi in the chest and cardialgia is one of important disease of heart system threatening middle-aged and elderly people life and health, and along with the change of modern society's life style and dietary structure, morbidity has the trend increasing gradually, thereby primary disease more and more causes people's attention.Because primary disease shows as deficiency in origin and excess in superficiality, have complicated clinical manifestation and pathological change, and Chinese medicine is from entirety, has the advantage of comprehensive function, thereby is paid close attention to widely.
For primary disease deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive, stage of attack, is real in main to mark, and the catabasis, tonifying for deficiency syndrome was answered in its treatment, reducing for the excess syndrome taking deficiency in origin as main pathogenic characteristic.Deficiency in origin should be mended, and the deficiency of the negative and positive of qi and blood of the balance heart, has or not double virtual loss of seeing that liver,spleen,kidney is dirty, and regulate yin-yang fills blood, and adjusts partially declining of internal organs, especially should pay attention to reinforcing the heart gas, warm heart-yang; Mark is real in rushing down, turbid and regulate the flow of vital energy, invigorate blood circulation, Wen Tong, reduce phlegm, especially heavy promoting blood circulation to remove obstruction in the collateral, activating QI to eliminate phlegm for the stagnation of QI, blood stasis, cold coagulation, expectorant
Myocardial ischemia serious threat patient life.Although western medicine can take effect very soon, easily recurrence, therapeutic effect is not good, even makes a futile effort; Or be improved, see again Relapse rate, so that all that has been achieved is spoiled.And side effect is large, patient compliance is poor, and expensive, and patient can not bear.Therefore herbal treatment is subject to more and more patients' attention, and it shows the diseases such as the similar traditional Chinese medical science " thoracic obstruction ", " cardiopalmus " myocardial ischemia, but the clinical one that lacks can effectively be improved symptom, reduces the Chinese medicine preparation of relapse rate.
Summary of the invention
Technical problem to be solved by this invention is, what provide that a kind of toxic and side effects is little, therapeutic effect good and be difficult for recurrence is used for the treatment of Chinese medicine composition of myocardial ischemia and preparation method thereof.
In order to reach foregoing invention object, the invention provides a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia, described Chinese medicine composition comprises following raw medicinal material: Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis, Flos Carthami, Radix Puerariae, Radix Paeoniae Rubra, Herba Menthae, Radix Glycyrrhizae Preparata, Radix Platycodonis, Rhizoma Chuanxiong, Equisetum pratense, Lignum Dalbergiae Odoriferae, Radix Ilicis Pubescentis, Mitellae, Cortex Cinnamomi, Ganoderma, Cortex Fissistigmatis bracteolati Radicis, Semen Lepidii (Semen Descurainiae), Lignum Aquilariae Resinatum, Fructus Piperis Longi and Fructus Crataegi.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 10-30 weight portion, Radix Rehmanniae 10-20 weight portion, Radix Sophorae Flavescentis 10-30 weight portion, Flos Carthami 10-25 weight portion, Radix Puerariae 10-25 weight portion, Radix Paeoniae Rubra 10-15 weight portion, Herba Menthae 10-15 weight portion, Radix Glycyrrhizae Preparata 12-20 weight portion, Radix Platycodonis 12-18 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Equisetum pratense 15-25 weight portion, Lignum Dalbergiae Odoriferae 10-18 weight portion, Radix Ilicis Pubescentis 15-25 weight portion, Mitellae 10-15 weight portion, Cortex Cinnamomi 10-15 weight portion, Ganoderma 10-20 weight portion, Cortex Fissistigmatis bracteolati Radicis 5-12 weight portion, Semen Lepidii (Semen Descurainiae) 10-18 weight portion, Lignum Aquilariae Resinatum 10-20 weight portion, Fructus Piperis Longi 10-20 weight portion and Fructus Crataegi 10-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Radix Angelicae Sinensis 15-25 weight portion, Radix Rehmanniae 12-18 weight portion, Radix Sophorae Flavescentis 15-25 weight portion, Flos Carthami 15-20 weight portion, Radix Puerariae 15-20 weight portion, Radix Paeoniae Rubra 12-15 weight portion, Herba Menthae 10-13 weight portion, Radix Glycyrrhizae Preparata 15-18 weight portion, Radix Platycodonis 14-17 weight portion, Rhizoma Chuanxiong 12-18 weight portion, Equisetum pratense 18-23 weight portion, Lignum Dalbergiae Odoriferae 13-16 weight portion, Radix Ilicis Pubescentis 18-23 weight portion, Mitellae 12-15 weight portion, Cortex Cinnamomi 12-15 weight portion, Ganoderma 14-18 weight portion, Cortex Fissistigmatis bracteolati Radicis 7-10 weight portion, Semen Lepidii (Semen Descurainiae) 13-18 weight portion, Lignum Aquilariae Resinatum 15-20 weight portion, Fructus Piperis Longi 10-15 weight portion and Fructus Crataegi 15-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Radix Angelicae Sinensis 21 weight portions, Radix Rehmanniae 15 weight portions, Radix Sophorae Flavescentis 20 weight portions, Flos Carthami 17 weight portions, Radix Puerariae 18 weight portions, Radix Paeoniae Rubra 13 weight portions, Herba Menthae 12 weight portions, Radix Glycyrrhizae Preparata 17 weight portions, Radix Platycodonis 16 weight portions, Rhizoma Chuanxiong 15 weight portions, Equisetum pratense 21 weight portions, Lignum Dalbergiae Odoriferae 14 weight portions, Radix Ilicis Pubescentis 21 weight portions, Mitellae 14 weight portions, Cortex Cinnamomi 13 weight portions, Ganoderma 16 weight portions, Cortex Fissistigmatis bracteolati Radicis 8 weight portions, Semen Lepidii (Semen Descurainiae) 15 weight portions, Lignum Aquilariae Resinatum 18 weight portions, Fructus Piperis Longi 13 weight portions and Fructus Crataegi 18 weight portions.
In order better to realize foregoing invention object, the invention provides a kind of preparation method of the Chinese medicine composition that is used for the treatment of myocardial ischemia, wherein, the dosage form of described Chinese medicine composition is pill, described preparation method comprises the following steps: take all raw medicinal materials according to parts by weight, add raw medicinal material gross weight 5-7 water soaking doubly 30 minutes to 1 hour, heated and boiled 30 minutes, filter, filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly, and heating, boils 30 minutes for the second time, refilters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly again, and heated and boiled 30 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 DEG C, is cooled to Powderedly rub ball with the hands and get final product after being twisted into slice together with being mixed in Mel after oven dry.
In order better to realize foregoing invention object, the present invention also provides a kind of preparation method of the Chinese medicine composition that is used for the treatment of myocardial ischemia, and the dosage form of described Chinese medicine composition is capsule, and described preparation method comprises the following steps:
A, get Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami according to parts by weight, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, and medicinal residues are for subsequent use;
B, take the surplus stock medical material except Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami, and the medicinal residues of described step a mix, add 60%-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, adds for the first time 5-10 and doubly measures, add for the second time 5-10 and doubly measure, merge extractive liquid,, filters; 1.10-1.50 when concentrating filtrate to relative density and being 80 DEG C, precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 DEG C, obtains extractum;
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill grinding 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
Wherein, in described step a, the extraction of Radix Angelicae Sinensis, Radix Rehmanniae, the contained volatile oil of Radix Sophorae Flavescentis Flos Carthami, is steam distillation or supercritical fluid extraction.
In described step b, described extraction adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: Chinese medicine composition of the present invention has effect of blood circulation promoting and blood stasis dispelling, coronary circulation-promoting pain-relieving, has advantages of that at treatment myocardial ischemia therapeutic effect is good, be difficult for recurrence, toxic and side effects is little; In the present invention, each taste raw medicinal material interacts, and cures mainly Yu Xue Bi resistance, qi depression to blood stasis, deficiency of vital energy blood unsmooth, reach invigorate blood circulation, regulate the flow of vital energy, pain relieving improves local blood circulation and metabolism, strengthens the object of myocardium hemopoietic.
Detailed description of the invention
The invention provides a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia, comprise following raw medicinal material: Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis, Flos Carthami, Radix Puerariae, Radix Paeoniae Rubra, Herba Menthae, Radix Glycyrrhizae Preparata, Radix Platycodonis, Rhizoma Chuanxiong, Equisetum pratense, Lignum Dalbergiae Odoriferae, Radix Ilicis Pubescentis, Mitellae, Cortex Cinnamomi, Ganoderma, Cortex Fissistigmatis bracteolati Radicis, Semen Lepidii (Semen Descurainiae), Lignum Aquilariae Resinatum, Fructus Piperis Longi and Fructus Crataegi.
Wherein, the pharmacological property of each raw medicinal material is as follows:
Radix Angelicae Sinensis: its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, the really gas medicine in blood, the also panacea in blood.Approximately mending to mend of assistant, thus can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant logical to attack, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Radix Rehmanniae: there is antiinflammatory, anti-allergic effects.Radix Rehmanniae decoct gavage has obvious antagonism to rat formaldehyde arthritis and albumen arthritis, and can suppress the increase of the capillary permeability that granuloma that Oleum Terebinthinae subcutaneous injection causes and histamine cause. the mouse peritoneum inflammation that the vascular permeability that Rehmannia glutinosa Libosch Water extracting solution causes histamine increases and acetic acid causes has obvious inhibitory action, Ovum Gallus domesticus album induced Acute inflammation is also had to antiinflammatory action, and the alcohol of Radix Rehmanniae and ether extracting solution are without antiinflammatory action.Have antifungic action, Rehmannia glutinosa Libosch Water preserved material has inhibitory action to the growth of the multiple funguses such as trichophyton mentagrophytes, Gypsum Fibrosum sample microspore tinea bacterium, ulotrichy microspore's tinea bacterium and Du's big belly microspore tinea bacterium difficult to understand.There is the inhibitory action of antagonism dexamethasone to Pituitary Adrenal cortex system, and can promote the synthetic of adrenocortical hormone.
Radix Sophorae Flavescentis: property hardship, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment senile vaginitis, is often combined with Cortex Phellodendri, is the colpitic external use gynaecological good medicine for the treatment of.
Flos Carthami: warm in nature, acrid in the mouth.Function cures mainly and is applied to the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth do not fall, dead fetus in the uterus, is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood chamber, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollenly burst uneasyly, are cards of disharmony between QI and blood all, and non-Flos Carthami can not be adjusted.
Radix Puerariae: nature and flavor are sweet pungent is flat; Be included into spleen, stomach warp.There is yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness stops warm effect.Cold, the warm headache stiffness of the nape that cures the wound, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deafness.According to authoritative data books such as Compendium of Material Medica, " Chinese medicine voluminous dictionary ", " functional foods ", Radix Puerariae and goods thereof relieve inflammation or internal heat, toxin expelling, blood fat reducing, blood pressure lowering, cholesterol reducing, blood sugar lowering, fat-reducing, relieving constipation, prevention alzheimer disease, prevent arteriosclerosis, prevent the good effect of the cardiovascular and cerebrovascular diseases such as cerebral thrombosis.
Radix Paeoniae Rubra: hardship, be slightly cold, return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection." herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." property of medicine opinion ": control pathogen of the lung gas, Fu Zhong Xu pain, vim and vigour are gathered, and logical a surname's internal organs are gathered around gas, control evil pain deteriorated blood, disease bone heat when main, strong the five internal organs, the kidney invigorating gas, controls trusted subordinate's heavily fortified point swollen, and married woman's blood closes obstructed, and repercussive blood can lose pus." not Lu ": clear and coherent blood vessels, slow in, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder intestine and small intestine, subduing inflammation, time row cold and heat, attacked by pestiferous factors stomachache, lumbago.
Herba Menthae: one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, headache, conjunctival congestion, fever of the body, throat, the dental bed disease such as swell and ache.Place with can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.All herbal medicine, pungent, cool.Return lung, Liver Channel, there is the wind heat of dispersing, clearing throat, rash removing toxic substances, dispersing the stagnated live-QI to relieve the stagnation of QI and the effect such as antipruritic, be applicable to that cold, fever, headache, laryngopharynx swelling and pain, lossless, wind-fire acute conjunctivitis, rubella, skin are itched, the disease such as colic, dysentery and scrofula, external has slight analgesic effect, for neuralgia etc.
Radix Glycyrrhizae Preparata: property is flat, and sweet in the mouth, returns 12 warps.Have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer.In the traditional Chinese medical science, Radix Glycyrrhizae Preparata invigorating the spleen and replenishing QI, grows and coughs lung moistening, emergency removing toxic substances, mediation hundred medicines.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Shennong's Herbal is classified Radix Glycyrrhizae Preparata as top grade, says that Radix Glycyrrhizae Preparata has the merit of hard muscles and bones, longue meat, times strength and removing toxic substances, and energy treating disorders in five ZANG-organs six internal organs cold and heat pathogen and incised wound are swollen." Mingyi Bielu " says that Radix Glycyrrhizae Preparata energy warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, cough-relieving quench the thirst, separate hundred poison of drug.
Radix Platycodonis: be the dried roots of Campanulaceae Radix Platycodonis, bitter in the mouth, pungent, slightly warm in nature.Enter lung meridian.Energy expelling phlegm for arresting cough, and have lung qi dispersing, evacuation of pus effect.The direct stimulation of contained platycodin to oral cavity, throat, gastric mucosa, makes sputum dilution thereby reflexive ground increases bronchial mucosa hypersecretion, is easy to discharge; Radix Platycodonis has antitussive effect, has the antiinflammatory of enhancing and immunization, and its antiinflammatory intensity is similar to aspirin; Water extract can strengthen the phagocytic function of macrophage, strengthens the sterilizing power of neutrophilic leukocyte, improves lysozyme activity; Stress ulcer is had to preventive effect.The thick saponin of Radix Platycodonis has calmness, analgesia, refrigeration function, again can blood sugar lowering, cholesterol reducing, and relaxing smooth muscle.Platycodin has very strong haemolysis, but destroy and lose haemolysis oral can decomposition in digestive tract.
Rhizoma Chuanxiong: pungent, temperature.Return liver, gallbladder, pericardium channel.Function blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Chuanxiong is warm in nature, and energy promoting blood circulation to remove blood stasis, is the good medicine nourishing blood.
Equisetum pratense: bitter in the mouth; Property is put down.Function cures mainly: invigorate blood circulation; Diuresis; Anthelmintic.Atherosclerosis of aorta; Difficulty and pain in micturition is unfavorable; Intestinal parasitical diseases.Pharmacological action: 1. hypotensive effect, grass asks that type aqueous extract (1:1) has to rabbit different approaches administration (gavage, abdomen amine injection, intravenous injection) hypotensive effect showing very much, oral blood pressure lowering maintains 3-6h, compared with the blood pressure drops 31.2%(of political party meansigma methods), repeatedly apply without tachyphylaxis.Equisetum pratense aqueous extract makes the hypotensive effect enhanced sensitivity of acetylcholine, and cloudy stagnant medicine Ah the Cha product of M-cholinoceptor are given with rear, and its hypotensive effect weakens or disappears.The No.1 chaste tree of grass has the adrenergic boosting of inhibition; Compressive reaction due to blocking-up common carotid artery blood flow is had to inhibitory action; After cutting off the absent-minded nerve of fan, hypotensive effect is showing and is weakening, therefore think that Equisetum pratense has central inhibitory action.2. function of resisting myocardial ischemia, Equisetum pratense get thing (1g crude drug/ml) intravenous injection 1.5-3.0g/kg to Cavia porcellus by standard I I helical pitch electrocardiogram S-T section and T ripple due to thriving and prosperous body pituitrin increase, decreased heart rate, have the antagonism showing.Before can making electrocardiogram RR, PQ, OT and ORS interval compared with administration, showing and extending.Equisetum pratense extract 10-15 g/kg injects to mouse peritoneal, can improve hypoxia-bearing capability under low pressure and condition of normal pressure, strengthen in advance to hypoxia-bearing capability due to isoproterenol, make mice consumption rate reduce by 32.8% compared with matched group.Cardiac muscle 86Rb uptake ratio reduces respectively 8.2%, 26.4% in low dose group (10g/kg) and high dose group (15g/kg) compared with matched group; And can resist cardiac muscle and plasma C amkp increased content due to isoproterenol.3. central nerve inhibition effect, can strengthen the syngignoscism of pentobarbital sodium to mouse stomach with Equisetum pratense extracting solution 0.2g/10g or 0.4g/10g, make to rent and the time lengthening of sleeping yesterday into required time contracting yesterday.When Equisetum pratense is admired fondly people's drug administration by injection at 0.2g/140g abdomen, there is faint antagonism strychnine to shy Jue effect to mice, can extend and shy Jue incubation period; Same dosage also can obviously extend mice shies Jue incubation period to nikethamide.Prove that at hot plate method Equisetum pratense extracting solution 0.2g/10g lumbar injection has obvious analgesic activity.
Lignum Dalbergiae Odoriferae: be the dry duramen of leguminous plant Lignum Dalbergiae Odoriferae wingceltis Dalbergia odorifera T. Chen trunk and root.All can gather the whole year, removes sapwood, dries in the shade.Pungent, temperature.Return liver, spleen channel.Function with cure mainly promoting flow of QI and blood, pain relieving, hemostasis.For epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage.. " herbal classic is met former ": Lignum Dalbergiae Odoriferae red complexion, enter blood system and decline, thus for oral administration can promoting the circulation of blood broken stagnant, the outer painting analgesic therapy of can stopping blooding.Deficiently again tell redly, color stasis of blood taste not fresh person should add with it, and its merit and Ophicalcitum are loose not different.
Radix Ilicis Pubescentis: hardship, flat.Function cures mainly: blood circulation and channel invigorating, reducing swelling and alleviating pain, heat-clearing and toxic substances removing.For angina pectoris, myocardial infarction, thromboangiitis obliterans, central serous chorioretinopathy, tonsillitis, pharyngolaryngitis, infantile pneumonia, chilblain.
Mitellae: sweet in the mouth; Salty; Property is put down.Enter spleen, kidney two warps.Function cures mainly: diuresis; Mass in the abdomen disappears.Main dysuria; The hypochondriac lump; Edema; Distension.
Cortex Cinnamomi: pungent, temperature, cures mainly: for sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.Function cures mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had to phlegm-dispelling functions, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.
Cortex Fissistigmatis bracteolati Radicis: pungent, puckery, temperature.Function cures mainly: relaxing muscles and tendons, invigorate blood circulation, and hemostasis.For traumatic injury, fracture, traumatic hemorrhage.
Semen Lepidii (Semen Descurainiae): pungent; Bitter; Cold.Return lung meridian; Heart channel; Liver Channel; Stomach warp; Urinary bladder channel.Function: eliminating the pathogens from the lung sending down the abnormal ascending QI; Eliminating phlegm and relieving asthma; Inducing diuresis to remove edema; Let out by heresy.Cure mainly: sputum is stopped up the dyspnea and cough with excessive sputum of lung; Lung abscess; Edema; Breast abdomen hydrops; Dysuria; Chronic pulmonary heart disease; Breathing heavily of heart failure is swollen; Scrofula tuberculosis.
Lignum Aquilariae Resinatum: pungent, bitter, tepor.Return spleen, stomach, kidney channel.Function cures mainly: promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.For the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, the QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.
Fructus Piperis Longi: pungent, heat.Return stomach, large intestine channel.Function cures mainly: warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving.For coldness and pain in the epigastrium, vomiting, has loose bowels, migraine; External treatment toothache.
Fructus Crataegi: containing multivitamin, Crataegolic acid, tartaric acid, citric acid, malic acid etc., also contain the mineral such as flavonoid, lactone, saccharide, protein, fat and calcium, phosphorus, ferrum, contained lipolytic enzyme can promote the digestion of fat food.Promote gastric secretion and increase the functions such as gastric enzyme element.The traditional Chinese medical science thinks, Fructus Crataegi has the effects such as removing food stagnancyization is stagnant, convergence dysentery relieving, activating blood circulation to dissipate blood stasis.Cure mainly the diseases such as eating accumulation, chest and diaphragm feeling of fullness, the amenorrhea of hernia blood stasis.In Fructus Crataegi, contain the ingredient such as mountain terpenoid and pyrite class, there is significant blood vessel dilating and hypotensive effect, there is the function that strengthens cardiac muscle, arrhythmia, adjusting blood fat and cholesterol level, Fructus Crataegi has effect of activating blood circulation to dissipate blood stasis, contribute to remove local congestion state, traumatic injury is had to auxiliary curative effect; The generation of free radical is blocked and reduced to the contained substance such as flavonoid and vitamin C, carotene of Fructus Crataegi, and the immunity of energy enhancing body, has anti-aging, anticancer effect; In Fructus Crataegi, having relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 10-30 weight portion, Radix Rehmanniae 10-20 weight portion, Radix Sophorae Flavescentis 10-30 weight portion, Flos Carthami 10-25 weight portion, Radix Puerariae 10-25 weight portion, Radix Paeoniae Rubra 10-15 weight portion, Herba Menthae 10-15 weight portion, Radix Glycyrrhizae Preparata 12-20 weight portion, Radix Platycodonis 12-18 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Equisetum pratense 15-25 weight portion, Lignum Dalbergiae Odoriferae 10-18 weight portion, Radix Ilicis Pubescentis 15-25 weight portion, Mitellae 10-15 weight portion, Cortex Cinnamomi 10-15 weight portion, Ganoderma 10-20 weight portion, Cortex Fissistigmatis bracteolati Radicis 5-12 weight portion, Semen Lepidii (Semen Descurainiae) 10-18 weight portion, Lignum Aquilariae Resinatum 10-20 weight portion, Fructus Piperis Longi 10-20 weight portion and Fructus Crataegi 10-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Radix Angelicae Sinensis 15-25 weight portion, Radix Rehmanniae 12-18 weight portion, Radix Sophorae Flavescentis 15-25 weight portion, Flos Carthami 15-20 weight portion, Radix Puerariae 15-20 weight portion, Radix Paeoniae Rubra 12-15 weight portion, Herba Menthae 10-13 weight portion, Radix Glycyrrhizae Preparata 15-18 weight portion, Radix Platycodonis 14-17 weight portion, Rhizoma Chuanxiong 12-18 weight portion, Equisetum pratense 18-23 weight portion, Lignum Dalbergiae Odoriferae 13-16 weight portion, Radix Ilicis Pubescentis 18-23 weight portion, Mitellae 12-15 weight portion, Cortex Cinnamomi 12-15 weight portion, Ganoderma 14-18 weight portion, Cortex Fissistigmatis bracteolati Radicis 7-10 weight portion, Semen Lepidii (Semen Descurainiae) 13-18 weight portion, Lignum Aquilariae Resinatum 15-20 weight portion, Fructus Piperis Longi 10-15 weight portion and Fructus Crataegi 15-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Radix Angelicae Sinensis 21 weight portions, Radix Rehmanniae 15 weight portions, Radix Sophorae Flavescentis 20 weight portions, Flos Carthami 17 weight portions, Radix Puerariae 18 weight portions, Radix Paeoniae Rubra 13 weight portions, Herba Menthae 12 weight portions, Radix Glycyrrhizae Preparata 17 weight portions, Radix Platycodonis 16 weight portions, Rhizoma Chuanxiong 15 weight portions, Equisetum pratense 21 weight portions, Lignum Dalbergiae Odoriferae 14 weight portions, Radix Ilicis Pubescentis 21 weight portions, Mitellae 14 weight portions, Cortex Cinnamomi 13 weight portions, Ganoderma 16 weight portions, Cortex Fissistigmatis bracteolati Radicis 8 weight portions, Semen Lepidii (Semen Descurainiae) 15 weight portions, Lignum Aquilariae Resinatum 18 weight portions, Fructus Piperis Longi 13 weight portions and Fructus Crataegi 18 weight portions.
In the time that the dosage form of Chinese medicine composition is pill, described preparation method comprises the following steps: take all raw medicinal materials according to parts by weight, add raw medicinal material gross weight 5-7 water soaking doubly 30 minutes to 1 hour, heated and boiled 30 minutes, filters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly, and heating, boils 30 minutes for the second time, refilters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly again, and heated and boiled 30 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 DEG C, is cooled to be Powderedly twisted into slice together with being mixed in Mel after oven dry.
In the time that the dosage form of Chinese medicine composition is capsule, described preparation method comprises the following steps:
A, get Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami according to parts by weight, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, and medicinal residues are for subsequent use;
B, take the surplus stock medical material except Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami, and the medicinal residues of described step a mix, add 60%-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, adds for the first time 5-10 and doubly measures, add for the second time 5-10 and doubly measure, merge extractive liquid,, filters; 1.10-1.50 when concentrating filtrate to relative density and being 80 DEG C, precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 DEG C, obtains extractum;
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill grinding 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
Wherein, in described step a, the extraction of Radix Angelicae Sinensis, Radix Rehmanniae, the contained volatile oil of Radix Sophorae Flavescentis Flos Carthami, is steam distillation or supercritical fluid extraction.
In described step b, described extraction adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.
Embodiment 1 pill
The embodiment of the present invention provides a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia, wherein the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 15 weight portions, Radix Rehmanniae 18 weight portions, Radix Sophorae Flavescentis 25 weight portions, Flos Carthami 20 weight portions, Radix Puerariae 20 weight portions, Radix Paeoniae Rubra 12 weight portions, Herba Menthae 13 weight portions, Radix Glycyrrhizae Preparata 18 weight portions, Radix Platycodonis 17 weight portions, Rhizoma Chuanxiong 12 weight portions, Equisetum pratense 23 weight portions, Lignum Dalbergiae Odoriferae 13 weight portions, Radix Ilicis Pubescentis 18 weight portions, Mitellae 12 weight portions, Cortex Cinnamomi 15 weight portions, Ganoderma 18 weight portions, Cortex Fissistigmatis bracteolati Radicis 10 weight portions, Semen Lepidii (Semen Descurainiae) 18 weight portions, Lignum Aquilariae Resinatum 20 weight portions, Fructus Piperis Longi 10 weight portions and Fructus Crataegi 20 weight portions.
Preparation method is as follows: take all raw medicinal materials according to above-mentioned parts by weight, add raw medicinal material gross weight 5-7 water doubly, soak 30 minutes to 1 hour, heated and boiled 30 minutes, filters, and filtrate is for subsequent use; In filtering residue, add raw medicinal material gross weight 3-5 water doubly, heating, boils 30 minutes for the second time, refilters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly again, and heated and boiled 30 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 DEG C, is cooled to Powdered being twisted into together with being mixed in Mel and rubs ball with the hands after slice and obtain pill after oven dry.Every ball 5g.
Embodiment 2 capsules
The embodiment of the present invention also provides a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia, wherein the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 21 weight portions, Radix Rehmanniae 15 weight portions, Radix Sophorae Flavescentis 20 weight portions, Flos Carthami 17 weight portions, Radix Puerariae 18 weight portions, Radix Paeoniae Rubra 13 weight portions, Herba Menthae 12 weight portions, Radix Glycyrrhizae Preparata 17 weight portions, Radix Platycodonis 16 weight portions, Rhizoma Chuanxiong 15 weight portions, Equisetum pratense 21 weight portions, Lignum Dalbergiae Odoriferae 14 weight portions, Radix Ilicis Pubescentis 21 weight portions, Mitellae 14 weight portions, Cortex Cinnamomi 13 weight portions, Ganoderma 16 weight portions, Cortex Fissistigmatis bracteolati Radicis 8 weight portions, Semen Lepidii (Semen Descurainiae) 15 weight portions, Lignum Aquilariae Resinatum 18 weight portions, Fructus Piperis Longi 13 weight portions and Fructus Crataegi 18 weight portions.
Preparation method comprises the following steps:
A, get Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami according to above-mentioned parts by weight, add the water soaking 2 hours of 8 times of amounts, extract the volatile oil of 4 hours, collect volatile oil, medicinal liquid filters, and medicinal residues are for subsequent use; Radix Angelicae Sinensis, Radix Rehmanniae, the contained volatile oil of Radix Sophorae Flavescentis Flos Carthami be extracted as steam distillation or supercritical fluid extraction.
B, take the surplus stock medical material except Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami, and the medicinal residues of described step a mix, add 80% ethanol, soaks 1 hour, extract twice, each 1 hour, add for the first time 8 times of amounts, add for the second time 7 times of amounts, merge extractive liquid,, filtration; When concentrating filtrate to relative density and being 80 DEG C 1.20, precipitate with ethanol twice, adjusts concentration of alcohol to 80%, gets supernatant concentration to relative density while being 80 DEG C 1.30, obtains extractum; Wherein, extract and adopt membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for 4% of extractum and volatile oil gross mass, mix, with colloid mill grinding 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
Toxicity test
1, cumulative toxicity test: select 20 healthy mices, female, male each 10, taking the pill of the embodiment of the present invention 1 as object, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.Adopt above-mentioned test method taking the capsule of the embodiment of the present invention 2 as object, result is identical with the experimental result of embodiment 1.
2, acute toxicity test: taking the pill of the embodiment of the present invention 1 as object, give white mouse large enteral dispensing, observe 7 for 150 times of clinical consumption per day.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse vagina and damaged skin are carried out to irritation test, there are no irritative response and other untoward reaction.Toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.Adopt above-mentioned test method taking the capsule of the embodiment of the present invention 2 as object, result is identical with the experimental result of embodiment 1, and toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.
Clinical trial
1, data and method
Case selection: during selecting in May, 2010-2012 year August, the Patients with Myocardial Ischemia of my institute's diagnosis and treatment is totally 579 examples, wherein, male 231 examples, female's 348 examples, age 35-73 year, wherein 35-50 year person's 114 examples, 51-60 year person's 172 examples, 61-70 year 234 examples, more than 70 years old person 59 examples.Select 570 routine patients to be wherein divided at random three groups: embodiment group one, embodiment group two and matched group, every group of 190 examples.
Diagnostic criteria: it is positive that electrocardiogram treadmill or treadmill graded exercise test (inferior maximum dose) judge that the standard of myocardial ischemia meets the one of following situations: 1, occur classical angina in motion.2, in motion and after motion, be horizontal type or force down >=0.1mV of sagging type (being ischemic-type) ST section.As the former ST section person of forcing down, after motion, should on former basis, force down again 0.1mV.3, blood pressure in sporting declines.And hope, hear, ask, cut the dialectical myocardial ischemia that is further diagnosed as according to the traditional Chinese medical science.
Therapeutic Method:
Embodiment group one: take pill prepared by the embodiment of the present invention 1, every day three times, each 82 months is 1 course for the treatment of.
Embodiment group two: take the capsule of the preparation of the embodiment of the present invention 2, every day three times, each 32 months is 1 course for the treatment of.
Matched group: adopt FUFANG DANSHEN PIAN and DIAOXINXUE KANG JIAONANG to treat, FUFANG DANSHEN PIAN every day three times, each 2, DIAOXINXUE KANG JIAONANG every day three times, each 22 months was 1 course for the treatment of.
The standard of curative effect evaluation: cure: electrocardiogram treadmill or treadmill graded exercise test are negative, the blood supply of electrocardio diagram coronary artery obviously improves, and malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: electrocardiogram treadmill or treadmill graded exercise test, the blood supply of electrocardio diagram coronary artery obviously improves, and malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: electrocardiogram treadmill or treadmill graded exercise test are still positive, and malaise symptoms is unchanged.
Therapeutic outcome:
Referring to table 1 and table 2, as can be seen from Table 1, adopt Chinese medicine composition treatment myocardial ischemia of the present invention, on therapeutic effect, there is significant progress with respect to conventional medicament; As can be seen from Table 2, adopt traditional Chinese medicine composition for treating myocardial ischemia of the present invention, now treating significantly shortening on the course for the treatment of for conventional medicament.
Table 1 liang group is treated respectively Clinical efficacy comparison after 3 courses for the treatment of
| Group | Number of cases | Cure | Effectively | Invalid | Effective percentage |
| Embodiment group one | 190 | 88 | 93 | 9 | 95.3% |
| Embodiment group two | 190 | 87 | 96 | 7 | 96.3 |
| Matched group | 190 | 53 | 74 | 63 | 66.8% |
Three groups, table 2 is treated respectively healing and efficiently individual quantity and time comparison after 3 courses for the treatment of
| Group | Number of cases | 1st month | 2nd month | 3rd month |
| Embodiment group one | 181 | 36(19.9%) | 93(51.4%) | 52(28.7%) |
| Embodiment group two | 183 | 38(20.8) | 98(53.6) | 47(25.7) |
| Matched group | 127 | 16(12.6%) | 47(37.0%) | 64(50.4%) |
Known according to the clinical statistics of above table content, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; Embodiment group one and embodiment group two cured and effective 181 examples and 183 examples and matched group healing and effective 127 routine patients follow up a case by regular visits to 1 year half simultaneously, result statistics, in 181 examples of embodiment group one, 88 examples of healing are without recurrence, in effective 93 examples, have 3 example recurrences, relapse rate is 1.66%; 183 examples of embodiment group two, 87 examples of healing, without recurrence, have 2 example recurrences in effective 96 examples, and relapse rate is 1.09; In matched group 127,12 example recurrences in 53 examples of healing, 18 example recurrences in effective 74 examples, relapse rate is 23.62%.
Model case: grandson, male, 59 years old, suffers from myocardial ischemia more than 2 years, often agitation, the uneasiness of feeling bad, weak all over, cold perspiration, in motion, there is classical angina, and blood pressure in sporting decline, hope, hear, ask, cut the dialectical myocardial ischemia that is further diagnosed as according to the traditional Chinese medical science.Take the capsule of the embodiment of the present invention 2, every day three times, each 3, treat two months basic healings, the two weeks that continues to take medicine is cured, and follows up a case by regular visits to not recurrence in 1 year half.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (8)
1. be used for the treatment of the Chinese medicine composition of myocardial ischemia, it is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis, Flos Carthami, Radix Puerariae, Radix Paeoniae Rubra, Herba Menthae, Radix Glycyrrhizae Preparata, Radix Platycodonis, Rhizoma Chuanxiong, Equisetum pratense, Lignum Dalbergiae Odoriferae, Radix Ilicis Pubescentis, Mitellae, Cortex Cinnamomi, Ganoderma, Cortex Fissistigmatis bracteolati Radicis, Semen Lepidii (Semen Descurainiae), Lignum Aquilariae Resinatum, Fructus Piperis Longi and Fructus Crataegi.
2. the Chinese medicine composition that is used for the treatment of myocardial ischemia according to claim 1, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 10-30 weight portion, Radix Rehmanniae 10-20 weight portion, Radix Sophorae Flavescentis 10-30 weight portion, Flos Carthami 10-25 weight portion, Radix Puerariae 10-25 weight portion, Radix Paeoniae Rubra 10-15 weight portion, Herba Menthae 10-15 weight portion, Radix Glycyrrhizae Preparata 12-20 weight portion, Radix Platycodonis 12-18 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Equisetum pratense 15-25 weight portion, Lignum Dalbergiae Odoriferae 10-18 weight portion, Radix Ilicis Pubescentis 15-25 weight portion, Mitellae 10-15 weight portion, Cortex Cinnamomi 10-15 weight portion, Ganoderma 10-20 weight portion, Cortex Fissistigmatis bracteolati Radicis 5-12 weight portion, Semen Lepidii (Semen Descurainiae) 10-18 weight portion, Lignum Aquilariae Resinatum 10-20 weight portion, Fructus Piperis Longi 10-20 weight portion and Fructus Crataegi 10-20 weight portion.
3. the Chinese medicine composition that is used for the treatment of myocardial ischemia according to claim 1 and 2, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 15-25 weight portion, Radix Rehmanniae 12-18 weight portion, Radix Sophorae Flavescentis 15-25 weight portion, Flos Carthami 15-20 weight portion, Radix Puerariae 15-20 weight portion, Radix Paeoniae Rubra 12-15 weight portion, Herba Menthae 10-13 weight portion, Radix Glycyrrhizae Preparata 15-18 weight portion, Radix Platycodonis 14-17 weight portion, Rhizoma Chuanxiong 12-18 weight portion, Equisetum pratense 18-23 weight portion, Lignum Dalbergiae Odoriferae 13-16 weight portion, Radix Ilicis Pubescentis 18-23 weight portion, Mitellae 12-15 weight portion, Cortex Cinnamomi 12-15 weight portion, Ganoderma 14-18 weight portion, Cortex Fissistigmatis bracteolati Radicis 7-10 weight portion, Semen Lepidii (Semen Descurainiae) 13-18 weight portion, Lignum Aquilariae Resinatum 15-20 weight portion, Fructus Piperis Longi 10-15 weight portion and Fructus Crataegi 15-20 weight portion.
4. according to the Chinese medicine composition that is used for the treatment of myocardial ischemia described in claim 1-3 any one, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 21 weight portions, Radix Rehmanniae 15 weight portions, Radix Sophorae Flavescentis 20 weight portions, Flos Carthami 17 weight portions, Radix Puerariae 18 weight portions, Radix Paeoniae Rubra 13 weight portions, Herba Menthae 12 weight portions, Radix Glycyrrhizae Preparata 17 weight portions, Radix Platycodonis 16 weight portions, Rhizoma Chuanxiong 15 weight portions, Equisetum pratense 21 weight portions, Lignum Dalbergiae Odoriferae 14 weight portions, Radix Ilicis Pubescentis 21 weight portions, Mitellae 14 weight portions, Cortex Cinnamomi 13 weight portions, Ganoderma 16 weight portions, Cortex Fissistigmatis bracteolati Radicis 8 weight portions, Semen Lepidii (Semen Descurainiae) 15 weight portions, Lignum Aquilariae Resinatum 18 weight portions, Fructus Piperis Longi 13 weight portions and Fructus Crataegi 18 weight portions.
5. the preparation method of the Chinese medicine composition that is used for the treatment of myocardial ischemia as described in claim 1-4 any one, it is characterized in that, the dosage form of described Chinese medicine composition is pill, described preparation method comprises the following steps: take all raw medicinal materials according to parts by weight, add raw medicinal material gross weight 5-7 water soaking doubly 30 minutes to 1 hour, heated and boiled 30 minutes, filters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly, and heating, boils 30 minutes for the second time, refilters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly again, and heated and boiled 30 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 DEG C, is cooled to Powderedly rub ball with the hands and get final product after being twisted into slice together with being mixed in Mel after oven dry.
6. a preparation method for the Chinese medicine composition that is used for the treatment of myocardial ischemia as described in claim 1-4 any one, is characterized in that, the dosage form of described Chinese medicine composition is capsule, and described preparation method comprises the following steps:
A, get Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami according to parts by weight, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, and medicinal residues are for subsequent use;
B, take the surplus stock medical material except Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami, and the medicinal residues of described step a mix, add 60%-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, adds for the first time 5-10 and doubly measures, add for the second time 5-10 and doubly measure, merge extractive liquid,, filters; 1.10-1.50 when concentrating filtrate to relative density and being 80 DEG C, precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 DEG C, obtains extractum;
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill grinding 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
7. the preparation method of the Chinese medicine composition that is used for the treatment of myocardial ischemia according to claim 6, is characterized in that, in described step a, the extraction of Radix Angelicae Sinensis, Radix Rehmanniae, the contained volatile oil of Radix Sophorae Flavescentis Flos Carthami, is steam distillation or supercritical fluid extraction.
8. according to the preparation method of the Chinese medicine composition that is used for the treatment of myocardial ischemia described in claim 6 or 7, it is characterized in that, in described step b, described extraction adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410144523.3A CN103860773A (en) | 2014-04-11 | 2014-04-11 | Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410144523.3A CN103860773A (en) | 2014-04-11 | 2014-04-11 | Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103860773A true CN103860773A (en) | 2014-06-18 |
Family
ID=50900160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410144523.3A Pending CN103860773A (en) | 2014-04-11 | 2014-04-11 | Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103860773A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104522493A (en) * | 2014-12-14 | 2015-04-22 | 周亮 | Health porridge for treating coronary atherosclerosis and preparation method of health porridge |
| CN105012388A (en) * | 2015-08-13 | 2015-11-04 | 张永煜 | Traditional Chinese medicine composition preventing and curing cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN110236039A (en) * | 2019-06-14 | 2019-09-17 | 昆明科晔生物技术有限公司 | A kind of antifatigue white fragrant fruit beverage and preparation method thereof of refreshing oneself |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102784A (en) * | 1994-02-28 | 1995-05-24 | 虹雨集团公司 | Chinese patent medicine for prevention and control of ischemic cardio-cerebral angiopathy |
| CN1476849A (en) * | 2002-08-21 | 2004-02-25 | 韩海龙 | Medicine composition for promoting blood circulation and removing stasis |
| WO2013141818A1 (en) * | 2012-03-23 | 2013-09-26 | Moleac Pte Ltd | Composition comprising herbs |
-
2014
- 2014-04-11 CN CN201410144523.3A patent/CN103860773A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102784A (en) * | 1994-02-28 | 1995-05-24 | 虹雨集团公司 | Chinese patent medicine for prevention and control of ischemic cardio-cerebral angiopathy |
| CN1476849A (en) * | 2002-08-21 | 2004-02-25 | 韩海龙 | Medicine composition for promoting blood circulation and removing stasis |
| WO2013141818A1 (en) * | 2012-03-23 | 2013-09-26 | Moleac Pte Ltd | Composition comprising herbs |
Non-Patent Citations (2)
| Title |
|---|
| 吴学文等: "血府逐瘀汤加味治疗心绞痛56例", 《河南中医药学刊》 * |
| 邓广业: "活血化瘀法治疗冠心病心绞痛近况", 《中医药学报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104522493A (en) * | 2014-12-14 | 2015-04-22 | 周亮 | Health porridge for treating coronary atherosclerosis and preparation method of health porridge |
| CN105012388A (en) * | 2015-08-13 | 2015-11-04 | 张永煜 | Traditional Chinese medicine composition preventing and curing cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN105012388B (en) * | 2015-08-13 | 2019-12-06 | 张永煜 | A Chinese medicinal composition for preventing and treating cardiovascular and cerebrovascular diseases, and its preparation method |
| CN110236039A (en) * | 2019-06-14 | 2019-09-17 | 昆明科晔生物技术有限公司 | A kind of antifatigue white fragrant fruit beverage and preparation method thereof of refreshing oneself |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103520572B (en) | A kind of Chinese medicine composition being used for the treatment of atopic dermatitis and preparation method thereof | |
| CN103211930A (en) | Traditional Chinese preparation for reducing blood fat and blood pressure | |
| CN104740437A (en) | Traditional Chinese medicine composition for treating constipation and preparation method of traditional Chinese medicine composition | |
| CN103893670B (en) | Traditional Chinese medicine pill used for treating cardia-cerebrovascular diseases | |
| CN103919910A (en) | Medicine for treating coronary heart disease | |
| CN103860773A (en) | Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof | |
| CN105687788A (en) | Pharmaceutical composition capable of softening blood vessels and application thereof | |
| CN105232987A (en) | Traditional Chinese medicine promoting neurosurgery postoperative rehabilitation | |
| CN104815232A (en) | Traditional Chinese medicine preparation for treating primary pulmonary hypertension and preparation method thereof | |
| CN103705733B (en) | One treats ARR Chinese medicinal capsule and preparation method thereof | |
| CN105435131A (en) | Traditional Chinese medicine composition for treating chronic heart failure and preparation method thereof | |
| CN105233078A (en) | Traditional Chinese medicine composition for treating viral hepatitis | |
| CN105106916A (en) | Postpartum nursing traditional Chinese medicine | |
| CN104857121A (en) | Drug combination for curing hyperlipidemia and application thereof | |
| CN106166251A (en) | A kind of for Chinese medicine preparation treating asthma and preparation method thereof | |
| CN106362074A (en) | Novel traditional Chinese medicine composition for treating anorexia and preparation method thereof | |
| CN105343688A (en) | Medicine composition for treating myocardial infarction and application thereof | |
| CN105770760A (en) | Preparation for treating gastric ulcer and preparation method thereof | |
| CN105434987A (en) | Traditional Chinese medicine preparation for treating cerebral infarction | |
| CN105456951A (en) | Traditional Chinese medicine preparation for treating breast fibroadenoma and preparing method of traditional Chinese medicine preparation | |
| CN105079392A (en) | Preparation for treating ischialgia and preparation method thereof | |
| CN104922595A (en) | Traditional Chinese medicinal preparation for herpes zoster and preparation method thereof | |
| CN105079319A (en) | Prescription for treating sciatica | |
| CN104524535A (en) | Traditional Chinese medicine composition for treating chronic pulmonary heart disease and preparation method of traditional Chinese medicine composition | |
| CN104399038A (en) | Drug for treating gastritis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140618 |