CN103860773A - Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof Download PDF

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CN103860773A
CN103860773A CN201410144523.3A CN201410144523A CN103860773A CN 103860773 A CN103860773 A CN 103860773A CN 201410144523 A CN201410144523 A CN 201410144523A CN 103860773 A CN103860773 A CN 103860773A
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radix
chinese medicine
medicine composition
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胡海波
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胡海波
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Abstract

The invention discloses a traditional Chinese medicine composition for treating myocardial ischemia and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw herbal materials: angelica sinensis, radix rehmanniae recen, radix sophorae flavescentis, flowers carthami, root of kudzu vine, root of common peony, mint, honey-fried licorice root, platycodon grandiflorum, ligusticum wallichii, equisetum pretense, lignum dalbergiae odoriferae, pubescent holly root, turtle feet, cortex cinnamomi, lucid ganoderma, fissistigma bracteolatum, semen lepidii, agilawood, fructus piperis longi and hawthorn. The traditional Chinese medicine composition has the beneficial effects that the traditional Chinese medicine composition disclosed by the invention has the effects of promoting blood circulation to remove blood stasis, and promoting coronary circulation and relieving pain, and has the advantages of being good in treatment effect, short in treatment course, not easy to reappear and small in toxic and side effects on treatment of myocardial ischemia.

Description

Be used for the treatment of Chinese medicine composition of myocardial ischemia and preparation method thereof
 
Technical field
The present invention relates to derive from the medicinal preparation of plant, animal or raw mineral materials, particularly a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia and preparation method thereof.
 
Background technology
Myocardial ischemia, refers to that the hemoperfusion of heart reduces, and causes the oxygen supply of heart to reduce, and energy metabolism of myocardial is undesired, can not support a kind of pathological state of the normal work of heart.Have a strong impact on people's live and work, severe patient can cause myocardial infarction and sudden death.The health of myocardial ischemia serious harm middle-aged and elderly people, in recent years along with growth in the living standard, coronary atherosclerosis presents the trend of rejuvenation, and also there is the performance of myocardial ischemia in the youngster in some 20-30 years.
Myocardial ischemia reduces heart blood, and blood is to transmit the necessary material of blood, if lack blood, can cause anoxia, thereby cause heart not provide necessary energy for activity, can cause angina pectoris, cardiac function decline, arrhythmia etc.The common reason of myocardial ischemia is coronary atherosclerosis, secondly also has inflammation (rheumatic, syphilis, mucocutaneous lymphnode syndrome and thromboangitis obliterans etc.), spasm, thromboembolism, connective tissue disease, wound and congenital malformation etc. multiple.Epidemiological study finds, the significant risk factor relevant to atherosclerosis is that hyperlipemia, hypertension, diabetes, smoking, obesity, homocysteine increase, physical exertion is few, advanced age and male etc.Myocardial ischemia mostly occurred after 40 years old, and average prevalence is about 6.49%.Along with the raising of living standards of the people, myocardial ischemia is the trend rising year by year in the prevalence of China at present.Myocardial ischemia is commonly encountered diseases and the frequently-occurring disease of middle-aged and elderly people, often shows as: after there is breastbone when fatigue or psychentonia or precordial fullness pain, or tighten sample pain, and shoulder, left upper arm radiation left, continue 3-5 minutes, have a rest after spontaneous remission person, time with profuse sweating; When physical exertion, there is uncomfortable in chest, cardiopalmus, breathe hard, spontaneous remission person when rest; There is the throat pain relevant with motion and burn feeling, constriction, toothache etc.; Heavy meal, cold, there is chest pain, person uncomfortable in chest after drinking; When night, sleep pillow was low, feel chest distress, need high pillow clinostatism side to feel comfortable person; Sleep soundly or unexpected chest pain, cardiopalmus, dyspnea when daytime is flat sleeping, need sit up immediately or stand can alleviation person; When sexual life or firmly defecation, occur nervous, uncomfortable in chest, out of breath or chest pain is uncomfortable; Bradycardia, Blood pressure drop or the person of fainting of burst.
Myocardial ischemia belongs to motherland's medical science " thoracic obstruction ", " cardiopalmus " category.Chinese medicine thinks, obstruction of qi in the chest and cardialgia is due to healthy energy virtual loss, caused, the blood stasis turbid with expectorant such as diet, feelings will, cold-evil, the stagnation of QI, cold coagulation numbness resistance heart arteries and veins, taking Danzhong or left chest ictally feel oppressed, pain is as mainly facing a kind of disease of performance.The lighter accidental of short duration slight chest oppressiveness or dull pain, or be ictal Danzhong or the unclean sense of discomfort of left breast; Severe one sharp ache, or be squeezing sample angor.Often, with cardiopalmus, breathe hard, hypopnea, even dyspnea with rapid and short breath, uneasy in terror, pale complexion, cold spontaneous sweating etc.How by fatigue, heavy meal, cold and excited and bring out, also can be without obvious inducement or morbidity when quiet.
Obstruction of qi in the chest and cardialgia is one of important disease of heart system threatening middle-aged and elderly people life and health, and along with the change of modern society's life style and dietary structure, morbidity has the trend increasing gradually, thereby primary disease more and more causes people's attention.Because primary disease shows as deficiency in origin and excess in superficiality, have complicated clinical manifestation and pathological change, and Chinese medicine is from entirety, has the advantage of comprehensive function, thereby is paid close attention to widely.
For primary disease deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive, stage of attack, is real in main to mark, and the catabasis, tonifying for deficiency syndrome was answered in its treatment, reducing for the excess syndrome taking deficiency in origin as main pathogenic characteristic.Deficiency in origin should be mended, and the deficiency of the negative and positive of qi and blood of the balance heart, has or not double virtual loss of seeing that liver,spleen,kidney is dirty, and regulate yin-yang fills blood, and adjusts partially declining of internal organs, especially should pay attention to reinforcing the heart gas, warm heart-yang; Mark is real in rushing down, turbid and regulate the flow of vital energy, invigorate blood circulation, Wen Tong, reduce phlegm, especially heavy promoting blood circulation to remove obstruction in the collateral, activating QI to eliminate phlegm for the stagnation of QI, blood stasis, cold coagulation, expectorant
Myocardial ischemia serious threat patient life.Although western medicine can take effect very soon, easily recurrence, therapeutic effect is not good, even makes a futile effort; Or be improved, see again Relapse rate, so that all that has been achieved is spoiled.And side effect is large, patient compliance is poor, and expensive, and patient can not bear.Therefore herbal treatment is subject to more and more patients' attention, and it shows the diseases such as the similar traditional Chinese medical science " thoracic obstruction ", " cardiopalmus " myocardial ischemia, but the clinical one that lacks can effectively be improved symptom, reduces the Chinese medicine preparation of relapse rate.
 
Summary of the invention
Technical problem to be solved by this invention is, what provide that a kind of toxic and side effects is little, therapeutic effect good and be difficult for recurrence is used for the treatment of Chinese medicine composition of myocardial ischemia and preparation method thereof.
In order to reach foregoing invention object, the invention provides a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia, described Chinese medicine composition comprises following raw medicinal material: Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis, Flos Carthami, Radix Puerariae, Radix Paeoniae Rubra, Herba Menthae, Radix Glycyrrhizae Preparata, Radix Platycodonis, Rhizoma Chuanxiong, Equisetum pratense, Lignum Dalbergiae Odoriferae, Radix Ilicis Pubescentis, Mitellae, Cortex Cinnamomi, Ganoderma, Cortex Fissistigmatis bracteolati Radicis, Semen Lepidii (Semen Descurainiae), Lignum Aquilariae Resinatum, Fructus Piperis Longi and Fructus Crataegi.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 10-30 weight portion, Radix Rehmanniae 10-20 weight portion, Radix Sophorae Flavescentis 10-30 weight portion, Flos Carthami 10-25 weight portion, Radix Puerariae 10-25 weight portion, Radix Paeoniae Rubra 10-15 weight portion, Herba Menthae 10-15 weight portion, Radix Glycyrrhizae Preparata 12-20 weight portion, Radix Platycodonis 12-18 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Equisetum pratense 15-25 weight portion, Lignum Dalbergiae Odoriferae 10-18 weight portion, Radix Ilicis Pubescentis 15-25 weight portion, Mitellae 10-15 weight portion, Cortex Cinnamomi 10-15 weight portion, Ganoderma 10-20 weight portion, Cortex Fissistigmatis bracteolati Radicis 5-12 weight portion, Semen Lepidii (Semen Descurainiae) 10-18 weight portion, Lignum Aquilariae Resinatum 10-20 weight portion, Fructus Piperis Longi 10-20 weight portion and Fructus Crataegi 10-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Radix Angelicae Sinensis 15-25 weight portion, Radix Rehmanniae 12-18 weight portion, Radix Sophorae Flavescentis 15-25 weight portion, Flos Carthami 15-20 weight portion, Radix Puerariae 15-20 weight portion, Radix Paeoniae Rubra 12-15 weight portion, Herba Menthae 10-13 weight portion, Radix Glycyrrhizae Preparata 15-18 weight portion, Radix Platycodonis 14-17 weight portion, Rhizoma Chuanxiong 12-18 weight portion, Equisetum pratense 18-23 weight portion, Lignum Dalbergiae Odoriferae 13-16 weight portion, Radix Ilicis Pubescentis 18-23 weight portion, Mitellae 12-15 weight portion, Cortex Cinnamomi 12-15 weight portion, Ganoderma 14-18 weight portion, Cortex Fissistigmatis bracteolati Radicis 7-10 weight portion, Semen Lepidii (Semen Descurainiae) 13-18 weight portion, Lignum Aquilariae Resinatum 15-20 weight portion, Fructus Piperis Longi 10-15 weight portion and Fructus Crataegi 15-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Radix Angelicae Sinensis 21 weight portions, Radix Rehmanniae 15 weight portions, Radix Sophorae Flavescentis 20 weight portions, Flos Carthami 17 weight portions, Radix Puerariae 18 weight portions, Radix Paeoniae Rubra 13 weight portions, Herba Menthae 12 weight portions, Radix Glycyrrhizae Preparata 17 weight portions, Radix Platycodonis 16 weight portions, Rhizoma Chuanxiong 15 weight portions, Equisetum pratense 21 weight portions, Lignum Dalbergiae Odoriferae 14 weight portions, Radix Ilicis Pubescentis 21 weight portions, Mitellae 14 weight portions, Cortex Cinnamomi 13 weight portions, Ganoderma 16 weight portions, Cortex Fissistigmatis bracteolati Radicis 8 weight portions, Semen Lepidii (Semen Descurainiae) 15 weight portions, Lignum Aquilariae Resinatum 18 weight portions, Fructus Piperis Longi 13 weight portions and Fructus Crataegi 18 weight portions.
In order better to realize foregoing invention object, the invention provides a kind of preparation method of the Chinese medicine composition that is used for the treatment of myocardial ischemia, wherein, the dosage form of described Chinese medicine composition is pill, described preparation method comprises the following steps: take all raw medicinal materials according to parts by weight, add raw medicinal material gross weight 5-7 water soaking doubly 30 minutes to 1 hour, heated and boiled 30 minutes, filter, filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly, and heating, boils 30 minutes for the second time, refilters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly again, and heated and boiled 30 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 DEG C, is cooled to Powderedly rub ball with the hands and get final product after being twisted into slice together with being mixed in Mel after oven dry.
In order better to realize foregoing invention object, the present invention also provides a kind of preparation method of the Chinese medicine composition that is used for the treatment of myocardial ischemia, and the dosage form of described Chinese medicine composition is capsule, and described preparation method comprises the following steps:
A, get Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami according to parts by weight, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, and medicinal residues are for subsequent use;
B, take the surplus stock medical material except Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami, and the medicinal residues of described step a mix, add 60%-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, adds for the first time 5-10 and doubly measures, add for the second time 5-10 and doubly measure, merge extractive liquid,, filters; 1.10-1.50 when concentrating filtrate to relative density and being 80 DEG C, precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 DEG C, obtains extractum;
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill grinding 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
Wherein, in described step a, the extraction of Radix Angelicae Sinensis, Radix Rehmanniae, the contained volatile oil of Radix Sophorae Flavescentis Flos Carthami, is steam distillation or supercritical fluid extraction.
In described step b, described extraction adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.
 
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: Chinese medicine composition of the present invention has effect of blood circulation promoting and blood stasis dispelling, coronary circulation-promoting pain-relieving, has advantages of that at treatment myocardial ischemia therapeutic effect is good, be difficult for recurrence, toxic and side effects is little; In the present invention, each taste raw medicinal material interacts, and cures mainly Yu Xue Bi resistance, qi depression to blood stasis, deficiency of vital energy blood unsmooth, reach invigorate blood circulation, regulate the flow of vital energy, pain relieving improves local blood circulation and metabolism, strengthens the object of myocardium hemopoietic.
 
Detailed description of the invention
The invention provides a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia, comprise following raw medicinal material: Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis, Flos Carthami, Radix Puerariae, Radix Paeoniae Rubra, Herba Menthae, Radix Glycyrrhizae Preparata, Radix Platycodonis, Rhizoma Chuanxiong, Equisetum pratense, Lignum Dalbergiae Odoriferae, Radix Ilicis Pubescentis, Mitellae, Cortex Cinnamomi, Ganoderma, Cortex Fissistigmatis bracteolati Radicis, Semen Lepidii (Semen Descurainiae), Lignum Aquilariae Resinatum, Fructus Piperis Longi and Fructus Crataegi.
Wherein, the pharmacological property of each raw medicinal material is as follows:
Radix Angelicae Sinensis: its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, the really gas medicine in blood, the also panacea in blood.Approximately mending to mend of assistant, thus can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant logical to attack, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Radix Rehmanniae: there is antiinflammatory, anti-allergic effects.Radix Rehmanniae decoct gavage has obvious antagonism to rat formaldehyde arthritis and albumen arthritis, and can suppress the increase of the capillary permeability that granuloma that Oleum Terebinthinae subcutaneous injection causes and histamine cause. the mouse peritoneum inflammation that the vascular permeability that Rehmannia glutinosa Libosch Water extracting solution causes histamine increases and acetic acid causes has obvious inhibitory action, Ovum Gallus domesticus album induced Acute inflammation is also had to antiinflammatory action, and the alcohol of Radix Rehmanniae and ether extracting solution are without antiinflammatory action.Have antifungic action, Rehmannia glutinosa Libosch Water preserved material has inhibitory action to the growth of the multiple funguses such as trichophyton mentagrophytes, Gypsum Fibrosum sample microspore tinea bacterium, ulotrichy microspore's tinea bacterium and Du's big belly microspore tinea bacterium difficult to understand.There is the inhibitory action of antagonism dexamethasone to Pituitary Adrenal cortex system, and can promote the synthetic of adrenocortical hormone.
Radix Sophorae Flavescentis: property hardship, cold.GUIXIN, liver, stomac