CN103860773A - Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating myocardial ischemia and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw herbal materials: angelica sinensis, radix rehmanniae recen, radix sophorae flavescentis, flowers carthami, root of kudzu vine, root of common peony, mint, honey-fried licorice root, platycodon grandiflorum, ligusticum wallichii, equisetum pretense, lignum dalbergiae odoriferae, pubescent holly root, turtle feet, cortex cinnamomi, lucid ganoderma, fissistigma bracteolatum, semen lepidii, agilawood, fructus piperis longi and hawthorn. The traditional Chinese medicine composition has the beneficial effects that the traditional Chinese medicine composition disclosed by the invention has the effects of promoting blood circulation to remove blood stasis, and promoting coronary circulation and relieving pain, and has the advantages of being good in treatment effect, short in treatment course, not easy to reappear and small in toxic and side effects on treatment of myocardial ischemia.
Description
Technical field
The present invention relates to derive from the medicinal preparation of plant, animal or raw mineral materials, particularly a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia and preparation method thereof.
Background technology
Myocardial ischemia, refers to that the hemoperfusion of heart reduces, and causes the oxygen supply of heart to reduce, and energy metabolism of myocardial is undesired, can not support a kind of pathological state of the normal work of heart.Have a strong impact on people's live and work, severe patient can cause myocardial infarction and sudden death.The health of myocardial ischemia serious harm middle-aged and elderly people, in recent years along with growth in the living standard, coronary atherosclerosis presents the trend of rejuvenation, and also there is the performance of myocardial ischemia in the youngster in some 20-30 years.
Myocardial ischemia reduces heart blood, and blood is to transmit the necessary material of blood, if lack blood, can cause anoxia, thereby cause heart not provide necessary energy for activity, can cause angina pectoris, cardiac function decline, arrhythmia etc.The common reason of myocardial ischemia is coronary atherosclerosis, secondly also has inflammation (rheumatic, syphilis, mucocutaneous lymphnode syndrome and thromboangitis obliterans etc.), spasm, thromboembolism, connective tissue disease, wound and congenital malformation etc. multiple.Epidemiological study finds, the significant risk factor relevant to atherosclerosis is that hyperlipemia, hypertension, diabetes, smoking, obesity, homocysteine increase, physical exertion is few, advanced age and male etc.Myocardial ischemia mostly occurred after 40 years old, and average prevalence is about 6.49%.Along with the raising of living standards of the people, myocardial ischemia is the trend rising year by year in the prevalence of China at present.Myocardial ischemia is commonly encountered diseases and the frequently-occurring disease of middle-aged and elderly people, often shows as: after there is breastbone when fatigue or psychentonia or precordial fullness pain, or tighten sample pain, and shoulder, left upper arm radiation left, continue 3-5 minutes, have a rest after spontaneous remission person, time with profuse sweating; When physical exertion, there is uncomfortable in chest, cardiopalmus, breathe hard, spontaneous remission person when rest; There is the throat pain relevant with motion and burn feeling, constriction, toothache etc.; Heavy meal, cold, there is chest pain, person uncomfortable in chest after drinking; When night, sleep pillow was low, feel chest distress, need high pillow clinostatism side to feel comfortable person; Sleep soundly or unexpected chest pain, cardiopalmus, dyspnea when daytime is flat sleeping, need sit up immediately or stand can alleviation person; When sexual life or firmly defecation, occur nervous, uncomfortable in chest, out of breath or chest pain is uncomfortable; Bradycardia, Blood pressure drop or the person of fainting of burst.
Myocardial ischemia belongs to motherland's medical science " thoracic obstruction ", " cardiopalmus " category.Chinese medicine thinks, obstruction of qi in the chest and cardialgia is due to healthy energy virtual loss, caused, the blood stasis turbid with expectorant such as diet, feelings will, cold-evil, the stagnation of QI, cold coagulation numbness resistance heart arteries and veins, taking Danzhong or left chest ictally feel oppressed, pain is as mainly facing a kind of disease of performance.The lighter accidental of short duration slight chest oppressiveness or dull pain, or be ictal Danzhong or the unclean sense of discomfort of left breast; Severe one sharp ache, or be squeezing sample angor.Often, with cardiopalmus, breathe hard, hypopnea, even dyspnea with rapid and short breath, uneasy in terror, pale complexion, cold spontaneous sweating etc.How by fatigue, heavy meal, cold and excited and bring out, also can be without obvious inducement or morbidity when quiet.
Obstruction of qi in the chest and cardialgia is one of important disease of heart system threatening middle-aged and elderly people life and health, and along with the change of modern society's life style and dietary structure, morbidity has the trend increasing gradually, thereby primary disease more and more causes people's attention.Because primary disease shows as deficiency in origin and excess in superficiality, have complicated clinical manifestation and pathological change, and Chinese medicine is from entirety, has the advantage of comprehensive function, thereby is paid close attention to widely.
For primary disease deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive, stage of attack, is real in main to mark, and the catabasis, tonifying for deficiency syndrome was answered in its treatment, reducing for the excess syndrome taking deficiency in origin as main pathogenic characteristic.Deficiency in origin should be mended, and the deficiency of the negative and positive of qi and blood of the balance heart, has or not double virtual loss of seeing that liver,spleen,kidney is dirty, and regulate yin-yang fills blood, and adjusts partially declining of internal organs, especially should pay attention to reinforcing the heart gas, warm heart-yang; Mark is real in rushing down, turbid and regulate the flow of vital energy, invigorate blood circulation, Wen Tong, reduce phlegm, especially heavy promoting blood circulation to remove obstruction in the collateral, activating QI to eliminate phlegm for the stagnation of QI, blood stasis, cold coagulation, expectorant
Myocardial ischemia serious threat patient life.Although western medicine can take effect very soon, easily recurrence, therapeutic effect is not good, even makes a futile effort; Or be improved, see again Relapse rate, so that all that has been achieved is spoiled.And side effect is large, patient compliance is poor, and expensive, and patient can not bear.Therefore herbal treatment is subject to more and more patients' attention, and it shows the diseases such as the similar traditional Chinese medical science " thoracic obstruction ", " cardiopalmus " myocardial ischemia, but the clinical one that lacks can effectively be improved symptom, reduces the Chinese medicine preparation of relapse rate.
Summary of the invention
Technical problem to be solved by this invention is, what provide that a kind of toxic and side effects is little, therapeutic effect good and be difficult for recurrence is used for the treatment of Chinese medicine composition of myocardial ischemia and preparation method thereof.
In order to reach foregoing invention object, the invention provides a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia, described Chinese medicine composition comprises following raw medicinal material: Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis, Flos Carthami, Radix Puerariae, Radix Paeoniae Rubra, Herba Menthae, Radix Glycyrrhizae Preparata, Radix Platycodonis, Rhizoma Chuanxiong, Equisetum pratense, Lignum Dalbergiae Odoriferae, Radix Ilicis Pubescentis, Mitellae, Cortex Cinnamomi, Ganoderma, Cortex Fissistigmatis bracteolati Radicis, Semen Lepidii (Semen Descurainiae), Lignum Aquilariae Resinatum, Fructus Piperis Longi and Fructus Crataegi.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 10-30 weight portion, Radix Rehmanniae 10-20 weight portion, Radix Sophorae Flavescentis 10-30 weight portion, Flos Carthami 10-25 weight portion, Radix Puerariae 10-25 weight portion, Radix Paeoniae Rubra 10-15 weight portion, Herba Menthae 10-15 weight portion, Radix Glycyrrhizae Preparata 12-20 weight portion, Radix Platycodonis 12-18 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Equisetum pratense 15-25 weight portion, Lignum Dalbergiae Odoriferae 10-18 weight portion, Radix Ilicis Pubescentis 15-25 weight portion, Mitellae 10-15 weight portion, Cortex Cinnamomi 10-15 weight portion, Ganoderma 10-20 weight portion, Cortex Fissistigmatis bracteolati Radicis 5-12 weight portion, Semen Lepidii (Semen Descurainiae) 10-18 weight portion, Lignum Aquilariae Resinatum 10-20 weight portion, Fructus Piperis Longi 10-20 weight portion and Fructus Crataegi 10-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Radix Angelicae Sinensis 15-25 weight portion, Radix Rehmanniae 12-18 weight portion, Radix Sophorae Flavescentis 15-25 weight portion, Flos Carthami 15-20 weight portion, Radix Puerariae 15-20 weight portion, Radix Paeoniae Rubra 12-15 weight portion, Herba Menthae 10-13 weight portion, Radix Glycyrrhizae Preparata 15-18 weight portion, Radix Platycodonis 14-17 weight portion, Rhizoma Chuanxiong 12-18 weight portion, Equisetum pratense 18-23 weight portion, Lignum Dalbergiae Odoriferae 13-16 weight portion, Radix Ilicis Pubescentis 18-23 weight portion, Mitellae 12-15 weight portion, Cortex Cinnamomi 12-15 weight portion, Ganoderma 14-18 weight portion, Cortex Fissistigmatis bracteolati Radicis 7-10 weight portion, Semen Lepidii (Semen Descurainiae) 13-18 weight portion, Lignum Aquilariae Resinatum 15-20 weight portion, Fructus Piperis Longi 10-15 weight portion and Fructus Crataegi 15-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Radix Angelicae Sinensis 21 weight portions, Radix Rehmanniae 15 weight portions, Radix Sophorae Flavescentis 20 weight portions, Flos Carthami 17 weight portions, Radix Puerariae 18 weight portions, Radix Paeoniae Rubra 13 weight portions, Herba Menthae 12 weight portions, Radix Glycyrrhizae Preparata 17 weight portions, Radix Platycodonis 16 weight portions, Rhizoma Chuanxiong 15 weight portions, Equisetum pratense 21 weight portions, Lignum Dalbergiae Odoriferae 14 weight portions, Radix Ilicis Pubescentis 21 weight portions, Mitellae 14 weight portions, Cortex Cinnamomi 13 weight portions, Ganoderma 16 weight portions, Cortex Fissistigmatis bracteolati Radicis 8 weight portions, Semen Lepidii (Semen Descurainiae) 15 weight portions, Lignum Aquilariae Resinatum 18 weight portions, Fructus Piperis Longi 13 weight portions and Fructus Crataegi 18 weight portions.
In order better to realize foregoing invention object, the invention provides a kind of preparation method of the Chinese medicine composition that is used for the treatment of myocardial ischemia, wherein, the dosage form of described Chinese medicine composition is pill, described preparation method comprises the following steps: take all raw medicinal materials according to parts by weight, add raw medicinal material gross weight 5-7 water soaking doubly 30 minutes to 1 hour, heated and boiled 30 minutes, filter, filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly, and heating, boils 30 minutes for the second time, refilters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly again, and heated and boiled 30 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 DEG C, is cooled to Powderedly rub ball with the hands and get final product after being twisted into slice together with being mixed in Mel after oven dry.
In order better to realize foregoing invention object, the present invention also provides a kind of preparation method of the Chinese medicine composition that is used for the treatment of myocardial ischemia, and the dosage form of described Chinese medicine composition is capsule, and described preparation method comprises the following steps:
A, get Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami according to parts by weight, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, and medicinal residues are for subsequent use;
B, take the surplus stock medical material except Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami, and the medicinal residues of described step a mix, add 60%-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, adds for the first time 5-10 and doubly measures, add for the second time 5-10 and doubly measure, merge extractive liquid,, filters; 1.10-1.50 when concentrating filtrate to relative density and being 80 DEG C, precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 DEG C, obtains extractum;
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill grinding 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
Wherein, in described step a, the extraction of Radix Angelicae Sinensis, Radix Rehmanniae, the contained volatile oil of Radix Sophorae Flavescentis Flos Carthami, is steam distillation or supercritical fluid extraction.
In described step b, described extraction adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: Chinese medicine composition of the present invention has effect of blood circulation promoting and blood stasis dispelling, coronary circulation-promoting pain-relieving, has advantages of that at treatment myocardial ischemia therapeutic effect is good, be difficult for recurrence, toxic and side effects is little; In the present invention, each taste raw medicinal material interacts, and cures mainly Yu Xue Bi resistance, qi depression to blood stasis, deficiency of vital energy blood unsmooth, reach invigorate blood circulation, regulate the flow of vital energy, pain relieving improves local blood circulation and metabolism, strengthens the object of myocardium hemopoietic.
Detailed description of the invention
The invention provides a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia, comprise following raw medicinal material: Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis, Flos Carthami, Radix Puerariae, Radix Paeoniae Rubra, Herba Menthae, Radix Glycyrrhizae Preparata, Radix Platycodonis, Rhizoma Chuanxiong, Equisetum pratense, Lignum Dalbergiae Odoriferae, Radix Ilicis Pubescentis, Mitellae, Cortex Cinnamomi, Ganoderma, Cortex Fissistigmatis bracteolati Radicis, Semen Lepidii (Semen Descurainiae), Lignum Aquilariae Resinatum, Fructus Piperis Longi and Fructus Crataegi.
Wherein, the pharmacological property of each raw medicinal material is as follows:
Radix Angelicae Sinensis: its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, the really gas medicine in blood, the also panacea in blood.Approximately mending to mend of assistant, thus can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant logical to attack, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Radix Rehmanniae: there is antiinflammatory, anti-allergic effects.Radix Rehmanniae decoct gavage has obvious antagonism to rat formaldehyde arthritis and albumen arthritis, and can suppress the increase of the capillary permeability that granuloma that Oleum Terebinthinae subcutaneous injection causes and histamine cause. the mouse peritoneum inflammation that the vascular permeability that Rehmannia glutinosa Libosch Water extracting solution causes histamine increases and acetic acid causes has obvious inhibitory action, Ovum Gallus domesticus album induced Acute inflammation is also had to antiinflammatory action, and the alcohol of Radix Rehmanniae and ether extracting solution are without antiinflammatory action.Have antifungic action, Rehmannia glutinosa Libosch Water preserved material has inhibitory action to the growth of the multiple funguses such as trichophyton mentagrophytes, Gypsum Fibrosum sample microspore tinea bacterium, ulotrichy microspore's tinea bacterium and Du's big belly microspore tinea bacterium difficult to understand.There is the inhibitory action of antagonism dexamethasone to Pituitary Adrenal cortex system, and can promote the synthetic of adrenocortical hormone.
Radix Sophorae Flavescentis: property hardship, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment senile vaginitis, is often combined with Cortex Phellodendri, is the colpitic external use gynaecological good medicine for the treatment of.
Flos Carthami: warm in nature, acrid in the mouth.Function cures mainly and is applied to the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth do not fall, dead fetus in the uterus, is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood chamber, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollenly burst uneasyly, are cards of disharmony between QI and blood all, and non-Flos Carthami can not be adjusted.
Radix Puerariae: nature and flavor are sweet pungent is flat; Be included into spleen, stomach warp.There is yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness stops warm effect.Cold, the warm headache stiffness of the nape that cures the wound, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deafness.According to authoritative data books such as Compendium of Material Medica, " Chinese medicine voluminous dictionary ", " functional foods ", Radix Puerariae and goods thereof relieve inflammation or internal heat, toxin expelling, blood fat reducing, blood pressure lowering, cholesterol reducing, blood sugar lowering, fat-reducing, relieving constipation, prevention alzheimer disease, prevent arteriosclerosis, prevent the good effect of the cardiovascular and cerebrovascular diseases such as cerebral thrombosis.
Radix Paeoniae Rubra: hardship, be slightly cold, return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection." herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." property of medicine opinion ": control pathogen of the lung gas, Fu Zhong Xu pain, vim and vigour are gathered, and logical a surname's internal organs are gathered around gas, control evil pain deteriorated blood, disease bone heat when main, strong the five internal organs, the kidney invigorating gas, controls trusted subordinate's heavily fortified point swollen, and married woman's blood closes obstructed, and repercussive blood can lose pus." not Lu ": clear and coherent blood vessels, slow in, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder intestine and small intestine, subduing inflammation, time row cold and heat, attacked by pestiferous factors stomachache, lumbago.
Herba Menthae: one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, headache, conjunctival congestion, fever of the body, throat, the dental bed disease such as swell and ache.Place with can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.All herbal medicine, pungent, cool.Return lung, Liver Channel, there is the wind heat of dispersing, clearing throat, rash removing toxic substances, dispersing the stagnated live-QI to relieve the stagnation of QI and the effect such as antipruritic, be applicable to that cold, fever, headache, laryngopharynx swelling and pain, lossless, wind-fire acute conjunctivitis, rubella, skin are itched, the disease such as colic, dysentery and scrofula, external has slight analgesic effect, for neuralgia etc.
Radix Glycyrrhizae Preparata: property is flat, and sweet in the mouth, returns 12 warps.Have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer.In the traditional Chinese medical science, Radix Glycyrrhizae Preparata invigorating the spleen and replenishing QI, grows and coughs lung moistening, emergency removing toxic substances, mediation hundred medicines.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Shennong's Herbal is classified Radix Glycyrrhizae Preparata as top grade, says that Radix Glycyrrhizae Preparata has the merit of hard muscles and bones, longue meat, times strength and removing toxic substances, and energy treating disorders in five ZANG-organs six internal organs cold and heat pathogen and incised wound are swollen." Mingyi Bielu " says that Radix Glycyrrhizae Preparata energy warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, cough-relieving quench the thirst, separate hundred poison of drug.
Radix Platycodonis: be the dried roots of Campanulaceae Radix Platycodonis, bitter in the mouth, pungent, slightly warm in nature.Enter lung meridian.Energy expelling phlegm for arresting cough, and have lung qi dispersing, evacuation of pus effect.The direct stimulation of contained platycodin to oral cavity, throat, gastric mucosa, makes sputum dilution thereby reflexive ground increases bronchial mucosa hypersecretion, is easy to discharge; Radix Platycodonis has antitussive effect, has the antiinflammatory of enhancing and immunization, and its antiinflammatory intensity is similar to aspirin; Water extract can strengthen the phagocytic function of macrophage, strengthens the sterilizing power of neutrophilic leukocyte, improves lysozyme activity; Stress ulcer is had to preventive effect.The thick saponin of Radix Platycodonis has calmness, analgesia, refrigeration function, again can blood sugar lowering, cholesterol reducing, and relaxing smooth muscle.Platycodin has very strong haemolysis, but destroy and lose haemolysis oral can decomposition in digestive tract.
Rhizoma Chuanxiong: pungent, temperature.Return liver, gallbladder, pericardium channel.Function blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Chuanxiong is warm in nature, and energy promoting blood circulation to remove blood stasis, is the good medicine nourishing blood.
Equisetum pratense: bitter in the mouth; Property is put down.Function cures mainly: invigorate blood circulation; Diuresis; Anthelmintic.Atherosclerosis of aorta; Difficulty and pain in micturition is unfavorable; Intestinal parasitical diseases.Pharmacological action: 1. hypotensive effect, grass asks that type aqueous extract (1:1) has to rabbit different approaches administration (gavage, abdomen amine injection, intravenous injection) hypotensive effect showing very much, oral blood pressure lowering maintains 3-6h, compared with the blood pressure drops 31.2%(of political party meansigma methods), repeatedly apply without tachyphylaxis.Equisetum pratense aqueous extract makes the hypotensive effect enhanced sensitivity of acetylcholine, and cloudy stagnant medicine Ah the Cha product of M-cholinoceptor are given with rear, and its hypotensive effect weakens or disappears.The No.1 chaste tree of grass has the adrenergic boosting of inhibition; Compressive reaction due to blocking-up common carotid artery blood flow is had to inhibitory action; After cutting off the absent-minded nerve of fan, hypotensive effect is showing and is weakening, therefore think that Equisetum pratense has central inhibitory action.2. function of resisting myocardial ischemia, Equisetum pratense get thing (1g crude drug/ml) intravenous injection 1.5-3.0g/kg to Cavia porcellus by standard I I helical pitch electrocardiogram S-T section and T ripple due to thriving and prosperous body pituitrin increase, decreased heart rate, have the antagonism showing.Before can making electrocardiogram RR, PQ, OT and ORS interval compared with administration, showing and extending.Equisetum pratense extract 10-15 g/kg injects to mouse peritoneal, can improve hypoxia-bearing capability under low pressure and condition of normal pressure, strengthen in advance to hypoxia-bearing capability due to isoproterenol, make mice consumption rate reduce by 32.8% compared with matched group.Cardiac muscle 86Rb uptake ratio reduces respectively 8.2%, 26.4% in low dose group (10g/kg) and high dose group (15g/kg) compared with matched group; And can resist cardiac muscle and plasma C amkp increased content due to isoproterenol.3. central nerve inhibition effect, can strengthen the syngignoscism of pentobarbital sodium to mouse stomach with Equisetum pratense extracting solution 0.2g/10g or 0.4g/10g, make to rent and the time lengthening of sleeping yesterday into required time contracting yesterday.When Equisetum pratense is admired fondly people's drug administration by injection at 0.2g/140g abdomen, there is faint antagonism strychnine to shy Jue effect to mice, can extend and shy Jue incubation period; Same dosage also can obviously extend mice shies Jue incubation period to nikethamide.Prove that at hot plate method Equisetum pratense extracting solution 0.2g/10g lumbar injection has obvious analgesic activity.
Lignum Dalbergiae Odoriferae: be the dry duramen of leguminous plant Lignum Dalbergiae Odoriferae wingceltis Dalbergia odorifera T. Chen trunk and root.All can gather the whole year, removes sapwood, dries in the shade.Pungent, temperature.Return liver, spleen channel.Function with cure mainly promoting flow of QI and blood, pain relieving, hemostasis.For epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage.. " herbal classic is met former ": Lignum Dalbergiae Odoriferae red complexion, enter blood system and decline, thus for oral administration can promoting the circulation of blood broken stagnant, the outer painting analgesic therapy of can stopping blooding.Deficiently again tell redly, color stasis of blood taste not fresh person should add with it, and its merit and Ophicalcitum are loose not different.
Radix Ilicis Pubescentis: hardship, flat.Function cures mainly: blood circulation and channel invigorating, reducing swelling and alleviating pain, heat-clearing and toxic substances removing.For angina pectoris, myocardial infarction, thromboangiitis obliterans, central serous chorioretinopathy, tonsillitis, pharyngolaryngitis, infantile pneumonia, chilblain.
Mitellae: sweet in the mouth; Salty; Property is put down.Enter spleen, kidney two warps.Function cures mainly: diuresis; Mass in the abdomen disappears.Main dysuria; The hypochondriac lump; Edema; Distension.
Cortex Cinnamomi: pungent, temperature, cures mainly: for sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.Function cures mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had to phlegm-dispelling functions, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.
Cortex Fissistigmatis bracteolati Radicis: pungent, puckery, temperature.Function cures mainly: relaxing muscles and tendons, invigorate blood circulation, and hemostasis.For traumatic injury, fracture, traumatic hemorrhage.
Semen Lepidii (Semen Descurainiae): pungent; Bitter; Cold.Return lung meridian; Heart channel; Liver Channel; Stomach warp; Urinary bladder channel.Function: eliminating the pathogens from the lung sending down the abnormal ascending QI; Eliminating phlegm and relieving asthma; Inducing diuresis to remove edema; Let out by heresy.Cure mainly: sputum is stopped up the dyspnea and cough with excessive sputum of lung; Lung abscess; Edema; Breast abdomen hydrops; Dysuria; Chronic pulmonary heart disease; Breathing heavily of heart failure is swollen; Scrofula tuberculosis.
Lignum Aquilariae Resinatum: pungent, bitter, tepor.Return spleen, stomach, kidney channel.Function cures mainly: promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.For the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, the QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.
Fructus Piperis Longi: pungent, heat.Return stomach, large intestine channel.Function cures mainly: warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving.For coldness and pain in the epigastrium, vomiting, has loose bowels, migraine; External treatment toothache.
Fructus Crataegi: containing multivitamin, Crataegolic acid, tartaric acid, citric acid, malic acid etc., also contain the mineral such as flavonoid, lactone, saccharide, protein, fat and calcium, phosphorus, ferrum, contained lipolytic enzyme can promote the digestion of fat food.Promote gastric secretion and increase the functions such as gastric enzyme element.The traditional Chinese medical science thinks, Fructus Crataegi has the effects such as removing food stagnancyization is stagnant, convergence dysentery relieving, activating blood circulation to dissipate blood stasis.Cure mainly the diseases such as eating accumulation, chest and diaphragm feeling of fullness, the amenorrhea of hernia blood stasis.In Fructus Crataegi, contain the ingredient such as mountain terpenoid and pyrite class, there is significant blood vessel dilating and hypotensive effect, there is the function that strengthens cardiac muscle, arrhythmia, adjusting blood fat and cholesterol level, Fructus Crataegi has effect of activating blood circulation to dissipate blood stasis, contribute to remove local congestion state, traumatic injury is had to auxiliary curative effect; The generation of free radical is blocked and reduced to the contained substance such as flavonoid and vitamin C, carotene of Fructus Crataegi, and the immunity of energy enhancing body, has anti-aging, anticancer effect; In Fructus Crataegi, having relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 10-30 weight portion, Radix Rehmanniae 10-20 weight portion, Radix Sophorae Flavescentis 10-30 weight portion, Flos Carthami 10-25 weight portion, Radix Puerariae 10-25 weight portion, Radix Paeoniae Rubra 10-15 weight portion, Herba Menthae 10-15 weight portion, Radix Glycyrrhizae Preparata 12-20 weight portion, Radix Platycodonis 12-18 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Equisetum pratense 15-25 weight portion, Lignum Dalbergiae Odoriferae 10-18 weight portion, Radix Ilicis Pubescentis 15-25 weight portion, Mitellae 10-15 weight portion, Cortex Cinnamomi 10-15 weight portion, Ganoderma 10-20 weight portion, Cortex Fissistigmatis bracteolati Radicis 5-12 weight portion, Semen Lepidii (Semen Descurainiae) 10-18 weight portion, Lignum Aquilariae Resinatum 10-20 weight portion, Fructus Piperis Longi 10-20 weight portion and Fructus Crataegi 10-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Radix Angelicae Sinensis 15-25 weight portion, Radix Rehmanniae 12-18 weight portion, Radix Sophorae Flavescentis 15-25 weight portion, Flos Carthami 15-20 weight portion, Radix Puerariae 15-20 weight portion, Radix Paeoniae Rubra 12-15 weight portion, Herba Menthae 10-13 weight portion, Radix Glycyrrhizae Preparata 15-18 weight portion, Radix Platycodonis 14-17 weight portion, Rhizoma Chuanxiong 12-18 weight portion, Equisetum pratense 18-23 weight portion, Lignum Dalbergiae Odoriferae 13-16 weight portion, Radix Ilicis Pubescentis 18-23 weight portion, Mitellae 12-15 weight portion, Cortex Cinnamomi 12-15 weight portion, Ganoderma 14-18 weight portion, Cortex Fissistigmatis bracteolati Radicis 7-10 weight portion, Semen Lepidii (Semen Descurainiae) 13-18 weight portion, Lignum Aquilariae Resinatum 15-20 weight portion, Fructus Piperis Longi 10-15 weight portion and Fructus Crataegi 15-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Radix Angelicae Sinensis 21 weight portions, Radix Rehmanniae 15 weight portions, Radix Sophorae Flavescentis 20 weight portions, Flos Carthami 17 weight portions, Radix Puerariae 18 weight portions, Radix Paeoniae Rubra 13 weight portions, Herba Menthae 12 weight portions, Radix Glycyrrhizae Preparata 17 weight portions, Radix Platycodonis 16 weight portions, Rhizoma Chuanxiong 15 weight portions, Equisetum pratense 21 weight portions, Lignum Dalbergiae Odoriferae 14 weight portions, Radix Ilicis Pubescentis 21 weight portions, Mitellae 14 weight portions, Cortex Cinnamomi 13 weight portions, Ganoderma 16 weight portions, Cortex Fissistigmatis bracteolati Radicis 8 weight portions, Semen Lepidii (Semen Descurainiae) 15 weight portions, Lignum Aquilariae Resinatum 18 weight portions, Fructus Piperis Longi 13 weight portions and Fructus Crataegi 18 weight portions.
In the time that the dosage form of Chinese medicine composition is pill, described preparation method comprises the following steps: take all raw medicinal materials according to parts by weight, add raw medicinal material gross weight 5-7 water soaking doubly 30 minutes to 1 hour, heated and boiled 30 minutes, filters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly, and heating, boils 30 minutes for the second time, refilters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly again, and heated and boiled 30 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 DEG C, is cooled to be Powderedly twisted into slice together with being mixed in Mel after oven dry.
In the time that the dosage form of Chinese medicine composition is capsule, described preparation method comprises the following steps:
A, get Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami according to parts by weight, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, and medicinal residues are for subsequent use;
B, take the surplus stock medical material except Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami, and the medicinal residues of described step a mix, add 60%-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, adds for the first time 5-10 and doubly measures, add for the second time 5-10 and doubly measure, merge extractive liquid,, filters; 1.10-1.50 when concentrating filtrate to relative density and being 80 DEG C, precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 DEG C, obtains extractum;
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill grinding 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
Wherein, in described step a, the extraction of Radix Angelicae Sinensis, Radix Rehmanniae, the contained volatile oil of Radix Sophorae Flavescentis Flos Carthami, is steam distillation or supercritical fluid extraction.
In described step b, described extraction adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.
Embodiment 1 pill
The embodiment of the present invention provides a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia, wherein the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 15 weight portions, Radix Rehmanniae 18 weight portions, Radix Sophorae Flavescentis 25 weight portions, Flos Carthami 20 weight portions, Radix Puerariae 20 weight portions, Radix Paeoniae Rubra 12 weight portions, Herba Menthae 13 weight portions, Radix Glycyrrhizae Preparata 18 weight portions, Radix Platycodonis 17 weight portions, Rhizoma Chuanxiong 12 weight portions, Equisetum pratense 23 weight portions, Lignum Dalbergiae Odoriferae 13 weight portions, Radix Ilicis Pubescentis 18 weight portions, Mitellae 12 weight portions, Cortex Cinnamomi 15 weight portions, Ganoderma 18 weight portions, Cortex Fissistigmatis bracteolati Radicis 10 weight portions, Semen Lepidii (Semen Descurainiae) 18 weight portions, Lignum Aquilariae Resinatum 20 weight portions, Fructus Piperis Longi 10 weight portions and Fructus Crataegi 20 weight portions.
Preparation method is as follows: take all raw medicinal materials according to above-mentioned parts by weight, add raw medicinal material gross weight 5-7 water doubly, soak 30 minutes to 1 hour, heated and boiled 30 minutes, filters, and filtrate is for subsequent use; In filtering residue, add raw medicinal material gross weight 3-5 water doubly, heating, boils 30 minutes for the second time, refilters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly again, and heated and boiled 30 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 DEG C, is cooled to Powdered being twisted into together with being mixed in Mel and rubs ball with the hands after slice and obtain pill after oven dry.Every ball 5g.
Embodiment 2 capsules
The embodiment of the present invention also provides a kind of Chinese medicine composition that is used for the treatment of myocardial ischemia, wherein the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 21 weight portions, Radix Rehmanniae 15 weight portions, Radix Sophorae Flavescentis 20 weight portions, Flos Carthami 17 weight portions, Radix Puerariae 18 weight portions, Radix Paeoniae Rubra 13 weight portions, Herba Menthae 12 weight portions, Radix Glycyrrhizae Preparata 17 weight portions, Radix Platycodonis 16 weight portions, Rhizoma Chuanxiong 15 weight portions, Equisetum pratense 21 weight portions, Lignum Dalbergiae Odoriferae 14 weight portions, Radix Ilicis Pubescentis 21 weight portions, Mitellae 14 weight portions, Cortex Cinnamomi 13 weight portions, Ganoderma 16 weight portions, Cortex Fissistigmatis bracteolati Radicis 8 weight portions, Semen Lepidii (Semen Descurainiae) 15 weight portions, Lignum Aquilariae Resinatum 18 weight portions, Fructus Piperis Longi 13 weight portions and Fructus Crataegi 18 weight portions.
Preparation method comprises the following steps:
A, get Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami according to above-mentioned parts by weight, add the water soaking 2 hours of 8 times of amounts, extract the volatile oil of 4 hours, collect volatile oil, medicinal liquid filters, and medicinal residues are for subsequent use; Radix Angelicae Sinensis, Radix Rehmanniae, the contained volatile oil of Radix Sophorae Flavescentis Flos Carthami be extracted as steam distillation or supercritical fluid extraction.
B, take the surplus stock medical material except Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami, and the medicinal residues of described step a mix, add 80% ethanol, soaks 1 hour, extract twice, each 1 hour, add for the first time 8 times of amounts, add for the second time 7 times of amounts, merge extractive liquid,, filtration; When concentrating filtrate to relative density and being 80 DEG C 1.20, precipitate with ethanol twice, adjusts concentration of alcohol to 80%, gets supernatant concentration to relative density while being 80 DEG C 1.30, obtains extractum; Wherein, extract and adopt membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for 4% of extractum and volatile oil gross mass, mix, with colloid mill grinding 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
Toxicity test
1, cumulative toxicity test: select 20 healthy mices, female, male each 10, taking the pill of the embodiment of the present invention 1 as object, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.Adopt above-mentioned test method taking the capsule of the embodiment of the present invention 2 as object, result is identical with the experimental result of embodiment 1.
2, acute toxicity test: taking the pill of the embodiment of the present invention 1 as object, give white mouse large enteral dispensing, observe 7 for 150 times of clinical consumption per day.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse vagina and damaged skin are carried out to irritation test, there are no irritative response and other untoward reaction.Toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.Adopt above-mentioned test method taking the capsule of the embodiment of the present invention 2 as object, result is identical with the experimental result of embodiment 1, and toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.
Clinical trial
1, data and method
Case selection: during selecting in May, 2010-2012 year August, the Patients with Myocardial Ischemia of my institute's diagnosis and treatment is totally 579 examples, wherein, male 231 examples, female's 348 examples, age 35-73 year, wherein 35-50 year person's 114 examples, 51-60 year person's 172 examples, 61-70 year 234 examples, more than 70 years old person 59 examples.Select 570 routine patients to be wherein divided at random three groups: embodiment group one, embodiment group two and matched group, every group of 190 examples.
Diagnostic criteria: it is positive that electrocardiogram treadmill or treadmill graded exercise test (inferior maximum dose) judge that the standard of myocardial ischemia meets the one of following situations: 1, occur classical angina in motion.2, in motion and after motion, be horizontal type or force down >=0.1mV of sagging type (being ischemic-type) ST section.As the former ST section person of forcing down, after motion, should on former basis, force down again 0.1mV.3, blood pressure in sporting declines.And hope, hear, ask, cut the dialectical myocardial ischemia that is further diagnosed as according to the traditional Chinese medical science.
Therapeutic Method:
Embodiment group one: take pill prepared by the embodiment of the present invention 1, every day three times, each 82 months is 1 course for the treatment of.
Embodiment group two: take the capsule of the preparation of the embodiment of the present invention 2, every day three times, each 32 months is 1 course for the treatment of.
Matched group: adopt FUFANG DANSHEN PIAN and DIAOXINXUE KANG JIAONANG to treat, FUFANG DANSHEN PIAN every day three times, each 2, DIAOXINXUE KANG JIAONANG every day three times, each 22 months was 1 course for the treatment of.
The standard of curative effect evaluation: cure: electrocardiogram treadmill or treadmill graded exercise test are negative, the blood supply of electrocardio diagram coronary artery obviously improves, and malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: electrocardiogram treadmill or treadmill graded exercise test, the blood supply of electrocardio diagram coronary artery obviously improves, and malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: electrocardiogram treadmill or treadmill graded exercise test are still positive, and malaise symptoms is unchanged.
Therapeutic outcome:
Referring to table 1 and table 2, as can be seen from Table 1, adopt Chinese medicine composition treatment myocardial ischemia of the present invention, on therapeutic effect, there is significant progress with respect to conventional medicament; As can be seen from Table 2, adopt traditional Chinese medicine composition for treating myocardial ischemia of the present invention, now treating significantly shortening on the course for the treatment of for conventional medicament.
Table 1 liang group is treated respectively Clinical efficacy comparison after 3 courses for the treatment of
| Group | Number of cases | Cure | Effectively | Invalid | Effective percentage |
| Embodiment group one | 190 | 88 | 93 | 9 | 95.3% |
| Embodiment group two | 190 | 87 | 96 | 7 | 96.3 |
| Matched group | 190 | 53 | 74 | 63 | 66.8% |
Three groups, table 2 is treated respectively healing and efficiently individual quantity and time comparison after 3 courses for the treatment of
| Group | Number of cases | 1st month | 2nd month | 3rd month |
| Embodiment group one | 181 | 36(19.9%) | 93(51.4%) | 52(28.7%) |
| Embodiment group two | 183 | 38(20.8) | 98(53.6) | 47(25.7) |
| Matched group | 127 | 16(12.6%) | 47(37.0%) | 64(50.4%) |
Known according to the clinical statistics of above table content, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; Embodiment group one and embodiment group two cured and effective 181 examples and 183 examples and matched group healing and effective 127 routine patients follow up a case by regular visits to 1 year half simultaneously, result statistics, in 181 examples of embodiment group one, 88 examples of healing are without recurrence, in effective 93 examples, have 3 example recurrences, relapse rate is 1.66%; 183 examples of embodiment group two, 87 examples of healing, without recurrence, have 2 example recurrences in effective 96 examples, and relapse rate is 1.09; In matched group 127,12 example recurrences in 53 examples of healing, 18 example recurrences in effective 74 examples, relapse rate is 23.62%.
Model case: grandson, male, 59 years old, suffers from myocardial ischemia more than 2 years, often agitation, the uneasiness of feeling bad, weak all over, cold perspiration, in motion, there is classical angina, and blood pressure in sporting decline, hope, hear, ask, cut the dialectical myocardial ischemia that is further diagnosed as according to the traditional Chinese medical science.Take the capsule of the embodiment of the present invention 2, every day three times, each 3, treat two months basic healings, the two weeks that continues to take medicine is cured, and follows up a case by regular visits to not recurrence in 1 year half.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (8)
1. be used for the treatment of the Chinese medicine composition of myocardial ischemia, it is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis, Flos Carthami, Radix Puerariae, Radix Paeoniae Rubra, Herba Menthae, Radix Glycyrrhizae Preparata, Radix Platycodonis, Rhizoma Chuanxiong, Equisetum pratense, Lignum Dalbergiae Odoriferae, Radix Ilicis Pubescentis, Mitellae, Cortex Cinnamomi, Ganoderma, Cortex Fissistigmatis bracteolati Radicis, Semen Lepidii (Semen Descurainiae), Lignum Aquilariae Resinatum, Fructus Piperis Longi and Fructus Crataegi.
2. the Chinese medicine composition that is used for the treatment of myocardial ischemia according to claim 1, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 10-30 weight portion, Radix Rehmanniae 10-20 weight portion, Radix Sophorae Flavescentis 10-30 weight portion, Flos Carthami 10-25 weight portion, Radix Puerariae 10-25 weight portion, Radix Paeoniae Rubra 10-15 weight portion, Herba Menthae 10-15 weight portion, Radix Glycyrrhizae Preparata 12-20 weight portion, Radix Platycodonis 12-18 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Equisetum pratense 15-25 weight portion, Lignum Dalbergiae Odoriferae 10-18 weight portion, Radix Ilicis Pubescentis 15-25 weight portion, Mitellae 10-15 weight portion, Cortex Cinnamomi 10-15 weight portion, Ganoderma 10-20 weight portion, Cortex Fissistigmatis bracteolati Radicis 5-12 weight portion, Semen Lepidii (Semen Descurainiae) 10-18 weight portion, Lignum Aquilariae Resinatum 10-20 weight portion, Fructus Piperis Longi 10-20 weight portion and Fructus Crataegi 10-20 weight portion.
3. the Chinese medicine composition that is used for the treatment of myocardial ischemia according to claim 1 and 2, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 15-25 weight portion, Radix Rehmanniae 12-18 weight portion, Radix Sophorae Flavescentis 15-25 weight portion, Flos Carthami 15-20 weight portion, Radix Puerariae 15-20 weight portion, Radix Paeoniae Rubra 12-15 weight portion, Herba Menthae 10-13 weight portion, Radix Glycyrrhizae Preparata 15-18 weight portion, Radix Platycodonis 14-17 weight portion, Rhizoma Chuanxiong 12-18 weight portion, Equisetum pratense 18-23 weight portion, Lignum Dalbergiae Odoriferae 13-16 weight portion, Radix Ilicis Pubescentis 18-23 weight portion, Mitellae 12-15 weight portion, Cortex Cinnamomi 12-15 weight portion, Ganoderma 14-18 weight portion, Cortex Fissistigmatis bracteolati Radicis 7-10 weight portion, Semen Lepidii (Semen Descurainiae) 13-18 weight portion, Lignum Aquilariae Resinatum 15-20 weight portion, Fructus Piperis Longi 10-15 weight portion and Fructus Crataegi 15-20 weight portion.
4. according to the Chinese medicine composition that is used for the treatment of myocardial ischemia described in claim 1-3 any one, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 21 weight portions, Radix Rehmanniae 15 weight portions, Radix Sophorae Flavescentis 20 weight portions, Flos Carthami 17 weight portions, Radix Puerariae 18 weight portions, Radix Paeoniae Rubra 13 weight portions, Herba Menthae 12 weight portions, Radix Glycyrrhizae Preparata 17 weight portions, Radix Platycodonis 16 weight portions, Rhizoma Chuanxiong 15 weight portions, Equisetum pratense 21 weight portions, Lignum Dalbergiae Odoriferae 14 weight portions, Radix Ilicis Pubescentis 21 weight portions, Mitellae 14 weight portions, Cortex Cinnamomi 13 weight portions, Ganoderma 16 weight portions, Cortex Fissistigmatis bracteolati Radicis 8 weight portions, Semen Lepidii (Semen Descurainiae) 15 weight portions, Lignum Aquilariae Resinatum 18 weight portions, Fructus Piperis Longi 13 weight portions and Fructus Crataegi 18 weight portions.
5. the preparation method of the Chinese medicine composition that is used for the treatment of myocardial ischemia as described in claim 1-4 any one, it is characterized in that, the dosage form of described Chinese medicine composition is pill, described preparation method comprises the following steps: take all raw medicinal materials according to parts by weight, add raw medicinal material gross weight 5-7 water soaking doubly 30 minutes to 1 hour, heated and boiled 30 minutes, filters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly, and heating, boils 30 minutes for the second time, refilters, and filtrate is for subsequent use; Filtering residue adds raw medicinal material gross weight 3-5 water doubly again, and heated and boiled 30 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 DEG C, is cooled to Powderedly rub ball with the hands and get final product after being twisted into slice together with being mixed in Mel after oven dry.
6. a preparation method for the Chinese medicine composition that is used for the treatment of myocardial ischemia as described in claim 1-4 any one, is characterized in that, the dosage form of described Chinese medicine composition is capsule, and described preparation method comprises the following steps:
A, get Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami according to parts by weight, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, and medicinal residues are for subsequent use;
B, take the surplus stock medical material except Radix Angelicae Sinensis, Radix Rehmanniae, Radix Sophorae Flavescentis Flos Carthami, and the medicinal residues of described step a mix, add 60%-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, adds for the first time 5-10 and doubly measures, add for the second time 5-10 and doubly measure, merge extractive liquid,, filters; 1.10-1.50 when concentrating filtrate to relative density and being 80 DEG C, precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 DEG C, obtains extractum;
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill grinding 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
7. the preparation method of the Chinese medicine composition that is used for the treatment of myocardial ischemia according to claim 6, is characterized in that, in described step a, the extraction of Radix Angelicae Sinensis, Radix Rehmanniae, the contained volatile oil of Radix Sophorae Flavescentis Flos Carthami, is steam distillation or supercritical fluid extraction.
8. according to the preparation method of the Chinese medicine composition that is used for the treatment of myocardial ischemia described in claim 6 or 7, it is characterized in that, in described step b, described extraction adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.
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| CN110236039A (en) * | 2019-06-14 | 2019-09-17 | 昆明科晔生物技术有限公司 | A kind of antifatigue white fragrant fruit beverage and preparation method thereof of refreshing oneself |
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Application publication date: 20140618 |