Summary of the invention
The inventor finds that in daily medical diagnosis on disease process existing treatment hyperlipidemia, hypertensive medicine exist above-mentioned defective deficiency, through exploration development and clinical trial for many years, also do not find relevant relevant report of the present invention, technical problem to be solved by this invention provides a kind of little blood fat reducing of hyperlipidemia, hypertension good effect, side effect, Chinese medicine preparation of blood pressure lowering for the treatment of.
For solving the problems of the technologies described above, the technical solution used in the present invention is that a kind of blood fat reducing of being developed, the Chinese medicine preparation of blood pressure lowering are formulated by following weight portion raw material Chinese medicine:
Radix Salviae Miltiorrhizae 6-10 part, Radix Polygoni Multiflori 6-8 part, Semen Cassiae 6-12 part, Herb Gynostemmae Pentaphylli 6-10 part, Fructus Hippophae 3-8 part, Radix Puerariae 6-10 part, Flos Chrysanthemi 3-6 part, Herba Apocyni veneti 5-10 part, Rhizoma Alismatis 6-10 part, Folium Notoginseng 3-6 part, Fructus Crataegi 3-8, Fructus Lycii 6-8 part.
Chinese medicine composition of the present invention is that the inventor sums up out through clinical practice for many years, with Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Herb Gynostemmae Pentaphylli, Herba Apocyni veneti is monarch drug, with Fructus Hippophae, Radix Puerariae, Flos Chrysanthemi, Fructus Lycii is ministerial drug, is adjuvant drug with Semen Cassiae, Fructus Crataegi, is messenger drug with Rhizoma Alismatis, Folium Notoginseng.The said medicine monarch is reasonably combined, synergism, nourishing kidney-yin, suppressing the hyperactive liver fire, blood circulation promoting and blood stasis dispelling, dredging the meridian, blood fat reducing effectively, blood pressure lowering.Wherein:
Radix Salviae Miltiorrhizae has another name called Radix Salviae Miltiorrhizae, and the nature and flavor hardship is slightly cold.GUIXIN, Liver Channel.Have promoting blood circulation to remove blood stasis, detumescence hemostasis, anti-inflammatory analgetic, menstruction regulating and pain relieving, coronary artery dilator, improve the myocardial ischemia situation, with all worries set aside, blood sugar lowering and effect such as antibiotic bring high blood pressure down, calm the nerves.To menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, diseases such as angina pectoris have certain curative effect.In addition, modern medicine experiment showed, that Radix Salviae Miltiorrhizae also has the function of anti-platelet aggregation, reduction blood viscosity and the inside and outside blood coagulation system of adjusting, is the natural Chinese medicine that a kind of safety is treated cardiovascular disease again reliably.
Radix Polygoni Multiflori, nature and flavor hardship, sweet, puckery, tepor.Return liver, kidney channel.Have enrich and benefit essence and blood, detoxifcation, preventing the attack (or recurrence) of malaria, the effect of loosening bowel to relieve constipation cures mainly the blood deficiency Light-headedness, cardiopalmus, insomnia, the soreness of the waist and knees of the hepatic and renal YIN deficiency, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, chronic malaria body void, rubella pruritus, carbuncle sore, scrofula, hemorrhoid.Radix Polygoni Multiflori can promote hemopoietic function, blood fat reducing and arteriosclerosis, raise immunity.
Semen Cassiae has another name called Semen Cassiae, cold nature, sweet, bitter, salty.Have that purging liver-fire, yin nourishing make eye bright, the hypertension and hyperlipemia effect.Cure mainly clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Be used for that the puckery pain of conjunctival congestion, the many tears of photophobia, headache are dizzy, poor vision, loosening bowel to relieve constipation.
Herb Gynostemmae Pentaphylli, nature and flavor hardship, little sweet, cold, nontoxic.Return lung, spleen, kidney channel.Has blood pressure regulation, blood fat reducing, blood sugar regulation, the effect of promotion urate excretion.Be used for blood fat, blood pressure, blood glucose, too high, the high or unusual person of blood uric acid.Herb Gynostemmae Pentaphylli tea also has more than 50 kind of Saponin except that containing sterol, sugar part, pigment, comprise tetracyclic triterpenoids compound.Gypenoside (GP), the same with the ginsenoside, can make platelet aggregation, prevent atherosclerosis, provide cell sufficient nutrient.The assurance blood flow is unobstructed.Reduce the cardiovascular and cerebrovascular vessel sickness rate.Because it also contains the saponin different with the ginsenoside, so Herb Gynostemmae Pentaphylli has calmness again, the effect of YIN nourishing has no side effect, and is suitable long-term edible.Clinical trial certificate, Herb Gynostemmae Pentaphylli not only has health-care effects such as allaying tiredness, appetite strengthening, tranquilizing soporific, slow down aging, aspect preventing and treating diseases such as hypertension, hyperlipidemia, coronary heart disease, diabetes, asthma, infectious hepatitis, migraine, remarkable effect is arranged also simultaneously.
Fructus Hippophae, nature and flavor acid, puckery, warm.Has relieving cough and resolving phlegm, invigorating the stomach and promoting digestion, the effect of promoting blood circulation to remove blood stasis.Cure mainly cough with copious phlegm, pulmonary abscess, dyspepsia, abdominal pain due to retention of food, stomachache, enteritis, amenorrhea, traumatic injury congestive edema.Fructus Hippophae and oil have very high medical value, but cholesterol reducing, the allevating angina pectoris outbreak, prevent and treat the effect of coronary atherosclerotic heart disease in addition, have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis, have and fall the effect that subtracts plasma cholesterol, reduces cholesterol level in the blood vessel wall, can prevent curing hyperlipemia and atherosclerosis, and the effect that promotes wound healing is arranged.
Radix Puerariae, nature and flavor are sweet, hot, cool.Return spleen, stomach, lung, warp.Has expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, deinebriating effect.Be used for the fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea is had loose bowels, dizziness and headache, apoplectic hemiplegia, obstruction of qi in the chest and cardialgia, damage of the spleen and stomach caused by alcoholism.According to authoritative data books such as Compendium of Material Medica, " Chinese medicine voluminous dictionary ", " functional foods ", Radix Puerariae and goods thereof relieve inflammation or internal heat, toxin expelling, blood fat reducing, blood pressure lowering, cholesterol reducing, blood sugar lowering, fat-reducing, relieving constipation, prevention alzheimer disease, prevent arteriosclerosis, prevent the good effect of cardiovascular and cerebrovascular diseases such as cerebral thrombosis.Radix Puerariae includes 12% flavone compound, and modern medicine study shows: the isoflavonoid puerarin in the Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.
Flos Chrysanthemi, nature and flavor suffering, sweet, bitter is slightly cold.Return lung, Liver Channel.Have the effect dispelling wind and heat pathogens, suppressing the hyperactive liver makes eye bright, heat-clearing toxin-expelling functions.Cure mainly anemopyretic cold, fever and headache, conjunctival congestion is dim-sighted, and deficiency of the liver and kindey, order are secretly dim-sighted, dizzy infantile convulsion, the rising for the treatment of the liver sun, it is dizzy to have a headache, kind wind and heat dispersing, purging liver-fire is held concurrently and can be made eye bright by tonifying YIN.
Herba Apocyni veneti, nature and flavor are sweet, bitter, cold.Return Liver Channel.Have suppressing the hyperactive liver and calm the nerves, the function of clearing away heat and promoting diuresis.Be used for dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; Hypertension, neurasthenia, nephritis edema.Modern medicine study shows, Folium Apocyni Veneti contains a large amount of flavone, triterpene, organic acid, chemical analysis such as aminoacid, further research flavone chemical constitution is Quercetin and isoquercitin glycoside, its pharmacological action has blood pressure lowering, blood fat reducing, increase coronary flow, to hypertension, hyperlipidemia, curative effect is preferably arranged, especially to dizzy symptom, improve sleep quality positive effect is arranged, has enhance immunity simultaneously, preventing cold, antiasthmatic-antitussive, eliminate depressed, the skin care of invigorating blood circulation, relieving alcoholism and protecting the liver, the degraded tobacco poisoning, vessel softening, effects such as relieving constipation diuresis have curative effect more than 80% to above symptom.
Rhizoma Alismatis, nature and flavor are sweet, light, cold.Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, treating stranguria effect expels the heat-evil.Cure mainly dysuria, the puckery pain of pyretic stranguria, the edema distension is had loose bowels, dizziness due to fluid-retention, seminal emission.On the Rhizoma Alismatis pharmacology effect for reducing blood fat is arranged, diuresis can reduce serum total cholesterol and triacylglycerol content, slows down atherosclerosis and forms.
Folium Notoginseng, sweet, the little hardship of nature and flavor, temperature.Return liver, stomach warp.Have the dissipating blood stasis hemostasis, the effect of subduing swelling and relieving pain cures mainly spitting of blood, spits blood, and epistaxis is had blood in stool, metrorrhagia, and traumatic hemorrhage, breast ventral spine pain, tumbling down swells and ache.The effect of Folium Notoginseng can blood vessel dilating, bring high blood pressure down microcirculation improvement, blood flow increasing, prevention and treatment heart and brain tissues ischemia, anoxia; Promote the blood cell metabolism, the balance adjustment blood cell; Hemostasis, blood circulation promoting and blood stasis dispelling; Two-ways regulation blood glucose, blood fat reducing, cholesterol, inhibition arteriosclerosis, slow down aging, enhancing human body immunity function.
Fructus Crataegi, nature and flavor acid, sweet, tepor.Return spleen, stomach, Liver Channel.Effect with appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm.Be used for carnivorous stagnate long-pending, lump in the abdomen, abdominal distention feeling of fullness, the stasis of blood resistance stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.Fructus Crataegi can prevent and treat cardiovascular disease, has blood vessel dilating, heart tonifying, coronary blood flow increasing, improves the heart vigor, the stimulating central nervous system system, brings high blood pressure down and cholesterol, vessel softening and diuresis and sedation; Prevent and treat arteriosclerosis, anti-aging, anticancer effect.Crataegolic acid also has cardiotonic, and is also helpful to senile heart disease.The immunity of energy enhancing body has anti-aging, anticancer effect.Having in the Fructus Crataegi relievings asthma reduces phlegm, suppresses antibacterial, the treatment abdominal pain diarrhea composition.
Fructus Lycii, nature and flavor are sweet, flat.Return liver, kidney, lung meridian.Has nourishing the liver, nourishing kidney, the effect of lung moistening.Be used for caused by liver and kidney deficiency, have a dizzy spell, visual deterioration, soreness of the waist and knees, seminal emission is quenched one's thirst, cough due to consumptive disease.Fructus Lycii can blood sugar lowering, blood fat reducing and blood pressure lowering, regulates immunity, the kidney invigorating.
Indication of the present invention: the relevant disease that is used for hyperlipidemia, hypertensive treatment and causes thus.
The treatment by Chinese herbs cycle of the present invention: 2-6 the course of treatment, be 30 days per course of treatment.
Chinese medicine of the present invention can be made into the regular dosage form of technical field of Chinese patent medicine.
Medicine of the present invention is nontoxic, have no side effect, and shows that through a large amount of clinical practices can reduce patient's blood fat, blood pressure effectively fast, after patient took half a year continuously, patient's state of an illness of 90% did not recur.
Clinical trial data
The Chinese medicine preparation of a kind of blood fat reducing of the present invention, blood pressure lowering is accepted patient's 131 examples for medical treatment through long-time observation on Clinical Application, and most of patient suffers from one or more in hyperlipidemia, the hypertension, what have also suffers from hyperglycemia, and 65.5 years old patient's mean age, maximum patient is 81 years old, minimum patient is 39 years old, the male patient has 79 examples, and female patient 52 examples are taken Chinese medicine of the present invention, every day three times, taking medicine before meal usefulness, is taken 2-6 the course of treatment continuously at 30 days one courses of treatment.Select medical history, the state of an illness, age, sex simultaneously and suitable with routine treatment suffer from hyperlipidemia, hyperpietic's 67 examples are organized in contrast, 61 years old patient's mean age, maximum patient is 79 years old, minimum patient is 43 years old, the male patient has 43 examples, female patient 24 examples compare observation according to the Therapeutic Method of routine.
The clinical diagnosis standard:
Hyperlipidemia: T-CHOL surpasses 5.72mmol/L in the serum, and triglyceride surpasses 1.70mmol/L.
Hypertension: systolic pressure meets or exceeds 21.3kPa (160mmHg) and diastolic pressure meets or exceeds 12.7kPa (95mm Hg).
Efficacy assessment standard:
Hyperlipidemia: recovery from illness, clinical symptoms, sign disappear or basic the disappearance, and the syndrome integration reduces 〉=95%; Produce effects, clinical symptoms, sign are obviously improved, and the syndrome integration reduces 〉=70%; Effectively, clinical symptoms, sign all take a favorable turn. and the syndrome integration reduces 〉=30%; Invalid, clinical symptoms, sign do not have obvious improvement, even increase the weight of, the syndrome integration reduces less than 30%.
Hypertension: recovery from illness, controlling of blood pressure is below horizontal at 140/90mmHg, does not have obvious clinical symptoms; Produce effects, controlling of blood pressure is below horizontal at 140/90mmHg, and obviously clinical symptoms is most of disappears; Effectively, controlling of blood pressure is below horizontal at 140/90mmHg, and obviously clinical symptoms partly disappears; Invalid, blood pressure does not reach above-mentioned level, and clinical symptoms is obvious.
Efficacy result: treatment group and matched group curative effect relatively see the following form.
Group |
Case load |
Invalid |
Effectively |
Produce effects |
Cure |
Effective percentage |
Cure rate |
The treatment group |
131 |
4 |
18 |
67 |
42 |
97% |
32% |
Matched group |
67 |
12 |
15 |
23 |
17 |
81% |
26% |
Further prove by above clinical trial, Chinese medicine the kidney invigorating suppressing the hyperactive liver of the present invention, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, benefiting QI and nourishing blood promotes the production of body fluid, effectively blood fat reducing, blood pressure.
The specific embodiment
The Chinese medicine preparation of a kind of blood fat reducing of the present invention, blood pressure lowering is formulated by following weight portion raw material Chinese medicine:
Radix Salviae Miltiorrhizae 6-10 part, Radix Polygoni Multiflori 6-8 part, Semen Cassiae 6-12 part, Herb Gynostemmae Pentaphylli 6-10 part, Fructus Hippophae 3-8 part, Radix Puerariae 6-10 part, Flos Chrysanthemi 3-6 part, Herba Apocyni veneti 5-10 part, Rhizoma Alismatis 6-10 part, Folium Notoginseng 3-6 part, Fructus Crataegi 3-8, Fructus Lycii 6-8 part.
Embodiment 1
Chinese medicine of the present invention is formulated by following weight portion raw material Chinese medicine:
6 parts of Radix Salviae Miltiorrhizae, 6 parts of Radix Polygoni Multiflori, 6 parts of Semen Cassiae, 6 parts of Herb Gynostemmae Pentaphylli, 3 parts of Fructus Hippophaes, 6 parts of Radix Puerariaes, 3 parts of Flos Chrysanthemis, 5 parts of Herba Apocyni venetis, 6 parts of Rhizoma Alismatis, 3 parts of Folium Notoginsengs, 3 parts of Fructus Crataegis, 6 parts of Fructus Lyciis.
Embodiment 2
Chinese medicine of the present invention is formulated by following weight portion raw material Chinese medicine:
10 parts of Radix Salviae Miltiorrhizae, 8 parts of Radix Polygoni Multiflori, 12 parts of Semen Cassiae, 10 parts of Herb Gynostemmae Pentaphylli, 8 parts of Fructus Hippophaes, 10 parts of Radix Puerariaes, 6 parts of Flos Chrysanthemis, 10 parts of Herba Apocyni venetis, 10 parts of Rhizoma Alismatis, 6 parts of Folium Notoginsengs, Fructus Crataegi 8,8 parts of Fructus Lyciis.
Embodiment 3
Chinese medicine of the present invention is formulated by following weight portion raw material Chinese medicine:
7 parts of Radix Salviae Miltiorrhizae, 6 parts of Radix Polygoni Multiflori, 7 parts of Semen Cassiae, 7 parts of Herb Gynostemmae Pentaphylli, 4 parts of Fructus Hippophaes, 7 parts of Radix Puerariaes, 4 parts of Flos Chrysanthemis, 6 parts of Herba Apocyni venetis, 7 parts of Rhizoma Alismatis, 4 parts of Folium Notoginsengs, Fructus Crataegi 4,7 parts of Fructus Lyciis.
Embodiment 4
Chinese medicine of the present invention is formulated by following weight portion raw material Chinese medicine:
9 parts of Radix Salviae Miltiorrhizae, 7 parts of Radix Polygoni Multiflori, 10 parts of Semen Cassiae, 9 parts of Herb Gynostemmae Pentaphylli, 7 parts of Fructus Hippophaes, 9 parts of Radix Puerariaes, 5 parts of Flos Chrysanthemis, 8 parts of Herba Apocyni venetis, 9 parts of Rhizoma Alismatis, 5 parts of Folium Notoginsengs, Fructus Crataegi 7,8 parts of Fructus Lyciis.
Embodiment 5
Chinese medicine of the present invention is formulated by following weight portion raw material Chinese medicine:
8 parts of Radix Salviae Miltiorrhizae, 7 parts of Radix Polygoni Multiflori, 9 parts of Semen Cassiae, 8 parts of Herb Gynostemmae Pentaphylli, 5 parts of Fructus Hippophaes, 8 parts of Radix Puerariaes, 5 parts of Flos Chrysanthemis, 7 parts of Herba Apocyni venetis, 8 parts of Rhizoma Alismatis, 5 parts of Folium Notoginsengs, 5 parts of Fructus Crataegis, 7 parts of Fructus Lyciis.
Enumerate some model cases below, so that curative effect of the present invention to be described.
Model case
XX surplus the case 1., the woman, 51 years old, Nanyang Wancheng District people suffered from hypertension and had a surplus in 5 years, and blood pressure maintains 180/120mmHg often, often dizzy headache, irascible temperament, irritability, insomnia and dreamful sleep, numb limbs and tense tendons, five is vexed hot-tempered, red tongue, thin fur, stringy and thready pulse was once obeyed various depressor, and effect is undesirable.After ask that to use treatment by Chinese herbs, card be the hepatic and renal YIN deficiency, excessive rising of liver-YANG is taken two courses of treatment of Chinese medicine of the present invention, symptom is clearly better, blood pressure is reduced to 150/95mmHg.The patient continues to take course of treatment of Chinese medicine of the present invention again, after pay a return visit, blood pressure stabilization, the mental status is good, does not occur the phenomenon of hypertension so far 2 years more.
Case 2. what XX, woman, 63 years old, people from Fangcheng County, Nanyang suffered from hypertension, hyperlipidemia 8 years, accompanied prescription on individual diagnosis in the autumn in 2008 by the household, the patient began hypertension before 8 years, repeatedly failed to respond to any medical treatment, and disease increases the weight of day by day, dizzy serious, so that be unable to leave the bed, life can't be taken care of oneself, complexion is floating red, last palpebra inferior duskiness, headache and dizziness, insomnia, build obesity, blood pressure 190/120mmHg, blood fat, T-CHOL are 8.6mmol/L, red tongue, yellow fur is thick, stringy and thready pulse, card is the hepatic and renal YIN deficiency, need nourishing the kidney and liver, blood circulation promoting and blood stasis dispelling, blood fat reducing.Throw course of treatment of Chinese medicine of the present invention, all diseases obviously alleviate, and life can take care of oneself, can the long distance of walking, after adhere to taking three courses of treatment, blood pressure is reduced to 130/85mmHg, T-CHOL is reduced to 4.6mmol/L, can normally go to work, it is good to follow up a case by regular visits in 3 years health, and blood pressure, blood fat do not raise.
Case 3. Liu XX, man, 71 years old, people from Tanghe County, Nanyang, retired cadre, the dizzy headache of patient main suit 5 years, right hemianesthesia 1 year, blood pressure 195/110mmHg during prescription on individual diagnosis, Western medicine diagnose are the hypertension II phase, take that to overpay western medicine result not good, after take Chinese medicine of the present invention, readme giddy, feeling of fullness in the head, headache, numb limbs and tense tendons alleviate after one month, blood pressure is reduced to 140/85 mmHg, after continuing to take two courses of treatment, symptom all disappears, and physical recovery is normal.
4. XX of case, man, 41 years old, Nanyang Wancheng District people, patient's height 174cm, 88 kilograms of body weight, dizzy three months of main suit, irritability, insomnia, sensation of oppression over the chest with shortness of breath, blood pressure 165/100 mmHg, stringy and thready pulse, body of the tongue is dim red, only can adhere to part-time employment, part-time job, part-time work, go to a doctor laboratory examination cholesterol 320mg%, beta Lipoprotein 1578mg% in the winter in 2007, triglyceride 96mg% is diagnosed as hypertension, hyperlipidemia, and it is not good always to take the Chinese medicine effect.Though after take medicine of the present invention, after one and half courses of treatment, weight in patients is reduced to 74 kilograms, blood pressure 126/80 mmHg, and the arteries and veins tongue is normal, cholesterol is reduced to 280 mg%, beta Lipoprotein is reduced to 460mg%, triglyceride 75mg%, patient's transference cure dizzy and uncomfortable in chest, can normally go to work, appear body in order.
Case 5. Lee XX, the man, 52 years old, people from Dengzhou, Nanyang, the cadre, private prosecution dizziness, insomnia, dreaminess, hypomnesis were had a surplus in 1 year, once arrived local examination in hospital, were diagnosed as hypertension, hyperlipidemia, early stage arteriosclerosis.Result of laboratory test cholesterol 235mg%, beta Lipoprotein 725mg%, triglyceride 120 mg%, blood pressure 160/98 mmHg takes Western medicine half a year, and curative effect is very little.After take Chinese medicine of the present invention, after the course of treatment, review result is that blood pressure is reduced to 116/80 mmHg, and cholesterol is reduced to 180 mg%, and beta Lipoprotein is reduced to 303mg%, and triglyceride is reduced to 78 mg%.Consolidate a course of treatment behind the patient again, every index was normal in 2 years so far.