Summary of the invention
It is not enough that inventor finds existing treatment hyperlipidemia in daily medical diagnosis on disease process, hypertensive medicine also exists above-mentioned defect, through exploration development for many years and clinical trial, also do not find relevant report for the present invention, technical problem to be solved by this invention is to provide a kind of Chinese medicine preparation for the treatment of the little blood fat reducing of hyperlipidemia, hypertension good effect, side effect, blood pressure lowering.
For solving the problems of the technologies described above, the technical solution used in the present invention is developed a kind of blood fat reducing, the Chinese medicine preparation of blood pressure lowering is formed by following raw material traditional Chinese medicine:
Radix Salviae Miltiorrhizae 6-10 part, Radix Polygoni Multiflori 6-8 part, Semen Cassiae 6-12 part, Herb Gynostemmae Pentaphylli 6-10 part, Fructus Hippophae 3-8 part, Radix Puerariae 6-10 part, Flos Chrysanthemi 3-6 part, Herba Apocyni veneti 5-10 part, Rhizoma Alismatis 6-10 part, Folium Notoginseng 3-6 part, Fructus Crataegi 3-8, Fructus Lycii 6-8 part.
Chinese medicine composition of the present invention is that inventor sums up out through clinical practice for many years, with Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Herb Gynostemmae Pentaphylli, Herba Apocyni veneti for monarch drug, with Fructus Hippophae, Radix Puerariae, Flos Chrysanthemi, Fructus Lycii for ministerial drug, with Semen Cassiae, Fructus Crataegi for adjuvant drug, with Rhizoma Alismatis, Folium Notoginseng for making medicine.Said medicine monarch is reasonably combined, synergism, nourishing kidney-yin, suppressing the hyperactive liver fire, blood circulation promoting and blood stasis dispelling, dredging the meridian, can blood fat reducing effectively, blood pressure lowering.Wherein:
Radix Salviae Miltiorrhizae, has another name called Radix Salviae Miltiorrhizae, and nature and flavor are bitter, are slightly cold.GUIXIN, Liver Channel.There is promoting blood circulation to remove blood stasis, detumescence hemostasis, anti-inflammatory analgetic, menstruction regulating and pain relieving, coronary artery dilator, improve myocardial ischemia situation, reduce blood pressure, calm the nerves with all worries set aside, blood sugar lowering and the effect such as antibacterial.To menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the diseases such as angina pectoris have certain curative effect.In addition, modern medicine experiment proves, Radix Salviae Miltiorrhizae also has anti-platelet aggregation, reduces the function of blood viscosity and the inside and outside blood coagulation system of adjustment, is the natural Chinese medicine that a kind of safety treats again cardiovascular disease reliably.
Radix Polygoni Multiflori, nature and flavor are bitter, sweet, puckery, tepor.Return liver, kidney channel.Have enrich and benefit essence and blood, removing toxic substances, preventing the attack (or recurrence) of malaria, effect of loosening bowel to relieve constipation, cures mainly blood deficiency Light-headedness, cardiopalmus, insomnia, the soreness of the waist and knees of the hepatic and renal YIN deficiency, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, and chronic malaria body is empty, rubella pruritus, carbuncle sore, scrofula, hemorrhoid.Radix Polygoni Multiflori can promote hemopoietic function, blood fat reducing and arteriosclerosis, strengthens immunologic function.
Semen Cassiae, has another name called Semen Cassiae, cold nature, sweet, bitter, salty.There is purging liver-fire, yin nourishing improving eyesight, hypertension and hyperlipemia effect.Cure mainly clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, have a headache dizzy, poor vision, loosening bowel to relieve constipation.
Herb Gynostemmae Pentaphylli, nature and flavor are bitter, micro-sweet, cool, nontoxic.Return lung, spleen, kidney channel.There is adjustment blood pressure, reduce blood fat, regulate blood glucose, promote effect of urate excretion.Too high, the high or abnormal person for blood fat, blood pressure, blood glucose, blood uric acid.Herb Gynostemmae Pentaphylli tea, except containing except sterol, sugared part, pigment, also has more than 50 kind of Saponin, comprises tetracyclic triterpenoids compound.Gypenoside (GP), the same with ginsenoside, can platelet aggregation be made, atherosclerosis, provide cell sufficient nutrient.Guarantee blood flow is unobstructed.Reduce cardiovascular and cerebrovascular vessel sickness rate.Because it is also containing the saponin different from ginsenoside, so Herb Gynostemmae Pentaphylli has calmness again, effect of YIN nourishing, has no side effect, should be long-term edible.Clinical trial certificate, Herb Gynostemmae Pentaphylli not only has the health-care effects such as allaying tiredness, appetite strengthening, tranquilizing soporific, slow down aging, simultaneously in the diseases such as prevention and treatment hypertension, hyperlipidemia, coronary heart disease, diabetes, asthma, infectious hepatitis, migraine, also there is remarkable effect.
Fructus Hippophae, nature and flavor are sour, puckery, warm.There is relieving cough and resolving phlegm, invigorating the stomach and promoting digestion, effect of promoting blood circulation to remove blood stasis.Cure mainly cough with copious phlegm, pulmonary abscess, dyspepsia, abdominal pain due to retention of food, stomachache, enteritis, amenorrhea, traumatic injury congestive edema.Fructus Hippophae and oil have very high medical value, cholesterol can be reduced, allevating angina pectoris shows effect, prevent and treat the effect of coronary atherosclerotic heart disease in addition, have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis, there is the effect of falling and subtracting plasma cholesterol, reducing cholesterol level in blood vessel wall, the anti-curing hyperlipemia of energy and atherosclerosis, and have the effect promoting wound healing.
Radix Puerariae, nature and flavor are sweet, pungent, cool.Return spleen, stomach, lung, warp.There is expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, deinebriating effect.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels, dizziness and headache, apoplectic hemiplegia, obstruction of qi in the chest and cardialgia, damage of the spleen and stomach caused by alcoholism.According to the authoritative data book such as Compendium of Material Medica, " Chinese medicine voluminous dictionary ", " functional food ", Radix Puerariae and goods thereof relieve inflammation or internal heat, toxin expelling, blood fat reducing, blood pressure lowering, cholesterol reducing, blood sugar lowering, fat-reducing, relieving constipation, prevention alzheimer disease, prevent arteriosclerosis, prevent the good effect of the cardiovascular and cerebrovascular diseases such as cerebral thrombosis.Radix Puerariae includes the flavone compound of 12%, and modern medicine study shows: the isoflavonoid puerarin in Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.
Flos Chrysanthemi, nature and flavor are pungent, sweet, bitter, are slightly cold.Return lung, Liver Channel.There is effect dispelling wind and heat pathogens, suppressing the hyperactive liver improving eyesight, heat-clearing toxin-expelling functions.Cure mainly anemopyretic cold, fever and headache, conjunctival congestion is dim-sighted, deficiency of the liver and kindey, and order is secretly dim-sighted, and dizzy infantile convulsion, controls excessive rising of liver-YANG, has a headache dizzy, kind wind and heat dispersing, purging liver-fire, and holding concurrently can tonifying YIN improving eyesight.
Herba Apocyni veneti, nature and flavor sweet, bitter, cold.Return Liver Channel.There is suppressing the hyperactive liver calm the nerves, the function of clearing away heat and promoting diuresis.For dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; Hypertension, neurasthenia, nephritis edema.Modern medicine study shows, Folium Apocyni Veneti contains a large amount of flavone, triterpene, organic acid, the chemical analysis such as aminoacid, further research flavone chemical constitution system's Quercetin and isoquercitrin, its pharmacological action has blood pressure lowering, blood fat reducing, increase coronary flow, to hypertension, hyperlipidemia, there is good curative effect, especially to dizziness, improving water flood quality has positive effect, have simultaneously and strengthen immunity, preventing cold, antiasthmatic-antitussive, eliminate depressed, to invigorate blood circulation skin care, relieving alcoholism and protecting the liver, degraded tobacco poisoning, vessel softening, the effects such as relieving constipation diuresis, above symptom is had to the curative effect of more than 80%.
Rhizoma Alismatis, nature and flavor are sweet, light, cold.Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, expel the heat-evil treating stranguria effect.Cure mainly dysuria, the puckery pain of pyretic stranguria, edema distension, has loose bowels, dizziness due to fluid-retention, seminal emission.Rhizoma Alismatis pharmacologically has effect for reducing blood fat, diuresis, can reduce serum total cholesterol and triacylglycerol content, slow down atherogenesis.
Folium Notoginseng, sweet, the micro-hardship of nature and flavor, temperature.Return liver, stomach warp.Have dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain, cures mainly spitting of blood, and spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast ventral spine pain, tumbling down swells and ache.The effect of Folium Notoginseng can blood vessel dilating, reduce blood pressure, improve microcirculation, increase blood flow, prevention and therapy heart and brain tissues ischemia, anoxia; Promote blood cell metabolism, balance adjustment blood cell; Hemostasis, blood circulation promoting and blood stasis dispelling; Two-ways regulation blood glucose, reduction blood fat, cholesterol, suppression arteriosclerosis, slow down aging, enhancing human body immunity function.
Fructus Crataegi, nature and flavor are sour, sweet, tepor.Return spleen, stomach, Liver Channel.There is appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, circulation of qi promoting of reducing phlegm effect.For meat stagnant long-pending, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.Fructus Crataegi energy prevention and cure of cardiovascular disease, has blood vessel dilating, heart tonifying, increase coronary flow, improves heart vigor, stimulating central nervous system system, reduces blood pressure and cholesterol, vessel softening and diuresis and sedation; Prevent and treat arteriosclerosis, anti-aging, anticancer effect.Crataegolic acid also has cardiotonic, also benefits to senile heart disease.The immunity of energy enhancing body, has anti-aging, anticancer effect.Having in Fructus Crataegi relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.
Fructus Lycii, nature and flavor are sweet, flat.Return liver, kidney, lung meridian.There is nourishing the liver, nourishing kidney, effect of lung moistening.For caused by liver and kidney deficiency, have a dizzy spell, visual deterioration, soreness of the waist and knees, seminal emission is quenched one's thirst, cough due to consumptive disease.Fructus Lycii can blood sugar lowering, blood fat reducing and blood pressure lowering, immunity moderation power, the kidney invigorating.
Indication of the present invention: for hyperlipidemia, hypertensive treatment and the relevant disease that causes thus.
In the treatment by Chinese herbs cycle of the present invention: 2-6 the course for the treatment of, per course for the treatment of is 30 days.
Chinese medicine of the present invention can be made into the regular dosage form of technical field of Chinese patent medicine.
Medicine of the present invention is nontoxic, have no side effect, and show through a large amount of clinical practice, effectively can reduce patients with lipid, blood pressure fast, after patient takes half a year continuously, patient's state of an illness of 90% does not recur.
Clinical trial data
The Chinese medicine preparation of a kind of blood fat reducing of the present invention, blood pressure lowering is through long-time observation on Clinical Application, and admitted patient 131 is routine, and most of patient suffers from one or more in hyperlipidemia, hypertension, what have also suffers from hyperglycemia, 65.5 years old patient's mean age, and maximum patient is 81 years old, minimum patient is 39 years old, male patient has 79 examples, and female patient 52 example, takes Chinese medicine of the present invention, every day three times, bfore meals, 30 days courses for the treatment of, take 2-6 the course for the treatment of continuously.Select medical history, the state of an illness, age, sex simultaneously and suitable with routine treatment suffer from hyperlipidemia, hyperpietic 67 example as a control group, 61 years old patient's mean age, maximum patient is 79 years old, minimum patient is 43 years old, male patient has 43 examples, female patient 24 example, Therapeutic Method conveniently carries out paired observation.
Clinical criteria:
Hyperlipidemia: in serum, T-CHOL is more than 5.72mmol/L, triglyceride is more than 1.70mmol/L.
Hypertension: systolic pressure meets or exceeds 21.3kPa (160mmHg) and diastolic pressure meets or exceeds 12.7kPa (95mm Hg).
Efficacy assessment standard:
Hyperlipidemia: recovery from illness, clinical symptoms, sign disappear or substantially disappear, and syndrome integral reduces >=95%; Effective, clinical symptoms, sign are obviously improved, and syndrome integral reduces >=70%; Effectively, clinical symptoms, sign all take a favorable turn. and syndrome integral reduces >=30%; Invalid, clinical symptoms, sign are not improved, even increase the weight of, syndrome integral reduces less than 30%.
Hypertension: recovery from illness, controlling of blood pressure is below horizontal at 140/90mmHg, without obvious clinical symptoms; Effective, controlling of blood pressure is below horizontal at 140/90mmHg, and obvious clinical symptoms major part disappears; Effectively, controlling of blood pressure is below horizontal at 140/90mmHg, obvious clinical symptoms partial disappearance; Invalid, blood pressure does not reach above-mentioned level, and clinical symptoms is obvious.
Efficacy result: treatment group and matched group comparitive study see the following form.
Group |
Case load |
Invalid |
Effectively |
Effective |
Cure |
Effective percentage |
Cure rate |
Treatment group |
131 |
4 |
18 |
67 |
42 |
97% |
32% |
Matched group |
67 |
12 |
15 |
23 |
17 |
81% |
26% |
Proved further by above clinical trial, Kidney-supplementing suppressing the hyperactive liver of the present invention, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, benefiting QI and nourishing blood, promotes the production of body fluid, and can effectively reduce blood fat, blood pressure.
Detailed description of the invention
The Chinese medicine preparation of a kind of blood fat reducing of the present invention, blood pressure lowering is formed by following raw material traditional Chinese medicine:
Radix Salviae Miltiorrhizae 6-10 part, Radix Polygoni Multiflori 6-8 part, Semen Cassiae 6-12 part, Herb Gynostemmae Pentaphylli 6-10 part, Fructus Hippophae 3-8 part, Radix Puerariae 6-10 part, Flos Chrysanthemi 3-6 part, Herba Apocyni veneti 5-10 part, Rhizoma Alismatis 6-10 part, Folium Notoginseng 3-6 part, Fructus Crataegi 3-8, Fructus Lycii 6-8 part.
Embodiment 1
Chinese medicine of the present invention is formed by following raw material traditional Chinese medicine:
Radix Salviae Miltiorrhizae 6 parts, Radix Polygoni Multiflori 6 parts, Semen Cassiae 6 parts, Herb Gynostemmae Pentaphylli 6 parts, Fructus Hippophae 3 parts, Radix Puerariae 6 parts, Flos Chrysanthemi 3 parts, Herba Apocyni veneti 5 parts, Rhizoma Alismatis 6 parts, Folium Notoginseng 3 parts, Fructus Crataegi 3 parts, Fructus Lycii 6 parts.
Embodiment 2
Chinese medicine of the present invention is formed by following raw material traditional Chinese medicine:
Radix Salviae Miltiorrhizae 10 parts, Radix Polygoni Multiflori 8 parts, Semen Cassiae 12 parts, Herb Gynostemmae Pentaphylli 10 parts, Fructus Hippophae 8 parts, Radix Puerariae 10 parts, Flos Chrysanthemi 6 parts, Herba Apocyni veneti 10 parts, Rhizoma Alismatis 10 parts, Folium Notoginseng 6 parts, Fructus Crataegi 8, Fructus Lycii 8 parts.
Embodiment 3
Chinese medicine of the present invention is formed by following raw material traditional Chinese medicine:
Radix Salviae Miltiorrhizae 7 parts, Radix Polygoni Multiflori 6 parts, Semen Cassiae 7 parts, Herb Gynostemmae Pentaphylli 7 parts, Fructus Hippophae 4 parts, Radix Puerariae 7 parts, Flos Chrysanthemi 4 parts, Herba Apocyni veneti 6 parts, Rhizoma Alismatis 7 parts, Folium Notoginseng 4 parts, Fructus Crataegi 4, Fructus Lycii 7 parts.
Embodiment 4
Chinese medicine of the present invention is formed by following raw material traditional Chinese medicine:
Radix Salviae Miltiorrhizae 9 parts, Radix Polygoni Multiflori 7 parts, Semen Cassiae 10 parts, Herb Gynostemmae Pentaphylli 9 parts, Fructus Hippophae 7 parts, Radix Puerariae 9 parts, Flos Chrysanthemi 5 parts, Herba Apocyni veneti 8 parts, Rhizoma Alismatis 9 parts, Folium Notoginseng 5 parts, Fructus Crataegi 7, Fructus Lycii 8 parts.
Embodiment 5
Chinese medicine of the present invention is formed by following raw material traditional Chinese medicine:
Radix Salviae Miltiorrhizae 8 parts, Radix Polygoni Multiflori 7 parts, Semen Cassiae 9 parts, Herb Gynostemmae Pentaphylli 8 parts, Fructus Hippophae 5 parts, Radix Puerariae 8 parts, Flos Chrysanthemi 5 parts, Herba Apocyni veneti 7 parts, Rhizoma Alismatis 8 parts, Folium Notoginseng 5 parts, Fructus Crataegi 5 parts, Fructus Lycii 7 parts.
Enumerate some model cases below, so that curative effect of the present invention to be described.
Model case
Case more than 1. XX, female, 51 years old, people from Wancheng District, Nanyang, suffer from hypertension and within 5 years, have a surplus, blood pressure maintains 180/120mmHg often, frequent giddy headache, irascible temperament, irritability, insomnia and dreamful sleep, numb limbs and tense tendons, five is vexed hot-tempered, red tongue, thin fur, stringy and thready pulse, once took various depressor, effect is undesirable.After ask with treatment by Chinese herbs, the card system hepatic and renal YIN deficiency, excessive rising of liver-YANG, take two courses for the treatment of of Chinese medicine of the present invention, symptom is clearly better, and blood pressure is down to 150/95mmHg.Patient continues again to take a course for the treatment of of Chinese medicine of the present invention, and by return visit, blood pressure stabilization, the mental status is good, does not occur the phenomenon that blood pressure raises 2 years so far more.
What XX of case 2., female, 63 years old, people from Fangcheng County, Nanyang, suffers from hypertension, hyperlipidemia 8 years, is accompanied to come to go to a doctor in the autumn in 2008 by household, patient started blood pressure and raises before 8 years, repeatedly fail to respond to any medical treatment, disease increases the weight of day by day, dizzy serious, so that be unable to leave the bed, life cannot be taken care of oneself, complexion is floated red, upper palpebra inferior duskiness, headache and dizziness, insomnia, build is fat, blood pressure 190/120mmHg, blood fat, T-CHOL are 8.6mmol/L, red tongue, yellow fur is thick, stringy and thready pulse, the card system hepatic and renal YIN deficiency, need nourishing the kidney and liver, blood circulation promoting and blood stasis dispelling, blood fat reducing.Throw a course for the treatment of of Chinese medicine of the present invention, all diseases obviously alleviate, and life can take care of oneself, can the long distance of walking, after adhere to taking three courses for the treatment of, blood pressure is down to 130/85mmHg, and T-CHOL is down to 4.6mmol/L, can normally go to work, well, blood pressure, blood fat do not raise to follow up a case by regular visits to health in 3 years.
Case 3. Liu XX, man, 71 years old, people from Tanghe County, Nanyang, retired cadre, patient main suit's giddy headache 5 years, right hemianesthesia 1 year, blood pressure 195/110mmHg time medical, Western medicine diagnose is hypertension II phase, take that to overpay western medicine result not good, after take Chinese medicine of the present invention, after one month, readme giddy, feeling of fullness in the head, headache, numb limbs and tense tendons alleviate, blood pressure is down to 140/85 mmHg, after continuing to take two courses for the treatment of, symptom all disappears, and physical recovery is normal.
Case 4. XX, man, 41 years old, people from Wancheng District, Nanyang, Patient height 174cm, body weight 88 kilograms, dizzy three months of main suit is irritable, insomnia, sensation of oppression over the chest with shortness of breath, blood pressure 165/100 mmHg, stringy and thready pulse, body of the tongue is dim red, only can adhere to part-time employment, part-time job, part-time work, go to a doctor in the winter in 2007, laboratory examination cholesterol 320mg%, beta Lipoprotein 1578mg%, triglyceride 96mg%, is diagnosed as hypertension, hyperlipidemia, takes Chinese medicine effect always not good.Though after take medicine of the present invention, after one and half courses for the treatment of, weight in patients is down to 74 kilograms, blood pressure 126/80 mmHg, and arteries and veins tongue is normal, cholesterol is down to 280 mg%, beta Lipoprotein is down to 460mg%, triglyceride 75mg%, the dizzy and transference cure uncomfortable in chest of patient, normally can go to work, appear body in order.
Case 5. Lee XX, man, 52 years old, people from Dengzhou, Nanyang, cadre, private prosecution dizziness, insomnia, dreaminess, hypomnesis were had a surplus for 1 year, once arrive local hospital inspection, are diagnosed as hypertension, hyperlipidemia, early stage arteriosclerosis.Result of laboratory test cholesterol 235mg%, beta Lipoprotein 725mg%, triglyceride 120 mg%, blood pressure 160/98 mmHg, take Western medicine half a year, curative effect is very micro-.By taking Chinese medicine of the present invention, after the course for the treatment of, review result is that blood pressure is down to 116/80 mmHg, and cholesterol is down to 180 mg%, and beta Lipoprotein is down to 303mg%, and triglyceride is down to 78 mg%.Consolidate again a course for the treatment of after patient, within 2 years so far, indices is normal.