CN103845670A - Electuary for treating coronary artery atherosclerosis and preparation method thereof - Google Patents
Electuary for treating coronary artery atherosclerosis and preparation method thereof Download PDFInfo
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- CN103845670A CN103845670A CN201410082159.2A CN201410082159A CN103845670A CN 103845670 A CN103845670 A CN 103845670A CN 201410082159 A CN201410082159 A CN 201410082159A CN 103845670 A CN103845670 A CN 103845670A
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Abstract
The invention discloses electuary for treating coronary artery atherosclerosis. The electuary is mainly prepared from the following raw material drugs in parts by weight: 6-9 pats of snakegourd fruit, 6-12 parts of tropic ageratum herb, 6-10 parts of cassia twig, 2-8 parts of sea buckhorn, 6-15 parts of allium macrostemon, 3-6 parts of mulberry bark, 4-9 parts of salviae miltiorrhizae, 5-9 parts of mussel, 2-5 parts of radix stemonae, 6-15 parts of pinellia ternata, 6-12 parts of polyporus umbellatus, 4-10 parts of rhizoma alismatis, and 3-9 parts of trogopterus dung. The electuary has the excellent effects that the selected materials are traditional Chinese medicinal materials, and do not have toxic or side effect; and the formula completely accords with traditional Chinese medicine principles and physical and mental characteristics of patients with coronary heart disease, different formulae with different functions can be prepared according to different crowds on the premise of the general principle. The electuary has the effects of activating blood circulation and stimulating meridians, eliminating blood stasis and relieving pain, and has a unique curative effect on treatment of coronary artery atherosclerosis and coronary heart diseases.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to electuary of a kind for the treatment of coronary atherosclerosis and preparation method thereof.
Background technology
Atherosclerosis (Atherosclerosis) is type the most common and important in arteriosclerosis, and the inner membrance of the tremulous pulse that is characterized in getting involved has the calmness of lipoids, the gathering of compound saccharide, and proliferation of fibrous tissue and calcific deposit then, and have medial pathological changes.Primary disease mainly involves large-scale and medium-sized flesh elastic-type tremulous pulse, take aorta, coronary artery and cerebral arteries as common, often causes obliteration or the tube wall serious consequence such as hemorrhage of breaking.The atherosclerosis occurring on coronary artery is called coronary atherosclerosis (Coronary Atherosclerotic).It is the atherosclerosis that the outer coronary artery of modal stenosis coronary artery disease, particularly flesh wall props up.Why coronary artery proximal section starts well pulse atherosclerosis is because it is than all close ventricles of all organ tremulous pulsies, thereby bears maximum systolic pressure shock.Moreover because the shape of heart has, most directions change coronary arterial vessel tree, therefore also bear larger blood flow shear stress.
Predilection site: according to the postmortem statistics of China, total recall rate of pathological changes, Stenosis and average rank are all the highest with anterior descending branch, and all the other are followed successively by right trunk, left trunk or LC, posterior descending branch.Sex difference: 20～50 years old detection rate of pathological change, male is significantly higher than women; Men and women's no significant difference after 60 years old.
Atherosclerosis is the basis that causes a series of hearts, cerebrovascular, and below we just carry out simply to tell about the mechanism of atherogenesis.The low density lipoprotein, LDL (Ox-LDL) of oxidation is atherosclerotic core, after the low density lipoprotein, LDL in blood (LDL) is by free-radical oxidations such as active oxygens (ROS), be " low density lipoprotein, LDL of oxidation " abbreviation " Ox-LDL ", he will intravasation wall, 1.Ox-LDL damages the endotheliocyte of blood vessel wall, and allows endotheliocyte gap become large; 2.Ox-LDL stimulates mononuclear cell migration intravasation wall; 3.OX-LDL is engulfed by the receptor of the smooth muscle cell of macrophage and blood vessel,----forming foam cell, 4.Ox-LDL makes the downright bad disintegrate of above-mentioned two kinds of foam cells, forms rotten atheonecrosis thing, and atherosclerotic plaque forms.
Here wanting ben is that the low density lipoprotein, LDL (Ox-LDL) being oxidized has played central role in whole atherogenesis process, rather than we common people " low density lipoprotein, LDL " or " blood fat " or " cholesterol " concept that it is generally acknowledged, be Ox-LDL if LDL is not oxidized, the mononuclear cell of body thinks that LDL is " one of own side ", can not engulf and form foam cell he (LDL), only have as he (LDL) and be oxidized to after Ox-LDL, just thought [dissident] composition by inflammatory mediators such as the mononuclear cells of body, and it is engulfed, eliminate, the final foam cell that forms.Therefore prevent that it is the atherosclerotic key point of containment that LDL is oxidized to Ox-LDL, rather than our conventional reduction cholesterol of understanding, reduce blood fat, reduce low density lipoprotein, LDL (LDL) etc.
Blood vessel after atherosclerosis, the formation of thrombosis is the inflammatory process of a more complicated.Along with the growth of above-mentioned atheromatous plaque, usually to cause above-mentioned foam cell death, form gangrenosum acne core, he can with the inflammatory reaction of sustainable existence, make above-mentioned atherosclerotic plaque become very unstable, the macrophage of activation is secreted a kind of enzymatic degradation collagen fiber cap, and unstable spot forms, and is so just easy to break.The substance release that speckle after breaking highly causes blood coagulation in a large number enters lumen of vessels, causes local thrombus to form.When this thrombosis is at the blood vessel of brain, be cerebral thrombosis (cerebral infarction, cerebral infarction), when cerebrovascular is in a weak position and with hypertension and so on, or speckle breaks and just formed cerebral hemorrhage outside blood vessel, this two classes situation traditional Chinese medical science apoplexy, doctor trained in Western medicine apoplexy; When this thrombosis is at the coronary artery of heart, be just myocardial infarction (myocardial infarction); When this thrombosis occurs in optical fundus tremulous pulse, it is exactly degeneration of macula.When this thrombosis form present artery of lower extremity time, just cause the change of foot disease and so on of picture diabetes.
Application publication number CN 102973786 A(application numbers 201210441546.1) Chinese patent literature a kind of Chinese medicine for the treatment of coronary atherosclerotic heart disease is disclosed, crude drug by following weight parts is made: Radix Angelicae Sinensis 6-10 part, Radix Notoginseng 3-5 part, Radix Scrophulariae 6-8 part, Flos Lonicerae 12-15 part, Radix Cynanchi Atrati 5-9 part, Ganoderma 14-18 part, Semen Lepidii (Semen Descurainiae) 10-13 part, Cortex Mori 8-10 part, Lignum Dalbergiae Odoriferae 6-8 part, Rhizoma Corydalis 10-12 part, Radix Codonopsis 15-20 part, Radix Glycyrrhizae 5-20 part, Radix Ophiopogonis 15-20 part, Magnetitum 20-25 part.Application publication number CN 103550624 A(application numbers 201310524895.4) Chinese patent literature a kind of Chinese medicine preparation for the treatment of atherosclerosis and coronary atherosclerosis is disclosed, its primary raw material and weight portion respectively, 30 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiong, 18 parts of the Radix Paeoniae Albas, 30 parts, Fructus Hordei Germinatus, 12 parts, Flos Carthami, 12 parts of Thallus Laminariae (Thallus Eckloniae)s, 10 parts of Herba Menthaes, 30 parts of Folium Fumicis Dentatis, 30 parts of Rhizoma Phragmitiss.
In a word, Chinese medicine is being obtained good curative effect aspect treatment primary disease, but also there are some problems: clinically control coronary atherosclerosis is also needed to synchronous research, the malaise symptoms curative effect that treatment coronary atherosclerosis is occurred also awaits further raising.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, the easy electuary of the treatment coronary atherosclerosis of clothes for a long time, this Chinese medicine composition determined curative effect and having no side effect.
Technical scheme of the present invention is:
The electuary for the treatment of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion: Fructus Trichosanthis 6-9, Herba Agerati Conyzoidis 6-12, Ramulus Cinnamomi 6-10, Fructus Hippophae 2-8, Bulbus Allii Macrostemonis 6-15, Cortex Mori 3-6, Radix Salviae Miltiorrhizae 4-9, Mytilus 5-9, Radix Stemonae 2-5, Rhizoma Pinelliae 6-15, Polyporus 6-12, Rhizoma Alismatis 4-10, Oletum Trogopterori 3-9.
The electuary of foregoing treatment coronary atherosclerosis, preferably, is mainly prepared from by following bulk drugs, be weight portion: Fructus Trichosanthis 7-8, Herba Agerati Conyzoidis 8-10, Ramulus Cinnamomi 7-9, Fructus Hippophae 4-6, Bulbus Allii Macrostemonis 9-12, Cortex Mori 4-5, Radix Salviae Miltiorrhizae 6-8, Mytilus 6-8, Radix Stemonae 3-4, Rhizoma Pinelliae 9-11, Polyporus 8-10, Rhizoma Alismatis 6-8, Oletum Trogopterori 5-7.
The electuary of foregoing treatment coronary atherosclerosis, more preferably good, be mainly prepared from by following bulk drugs, be weight portion: Fructus Trichosanthis 7.5, Herba Agerati Conyzoidis 9, Ramulus Cinnamomi 8, Fructus Hippophae 5, Bulbus Allii Macrostemonis 10, Cortex Mori 4.5, Radix Salviae Miltiorrhizae 7, Mytilus 7, the Radix Stemonae 3.5, the Rhizoma Pinelliae 10, Polyporus 9, Rhizoma Alismatis 7, Oletum Trogopterori 6.
The preparation method of the electuary of described treatment coronary atherosclerosis is:
(1) crude drug of putting in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, decoct 0.8-1.4 hour again, filter extracting juice, medicine juice merges, to every milliliter contained 1-3 gram, add ethanol (95%) the limit edged of one times of weight to stir by thin film evaporation, precipitate after 15-25 hour and filter;
(2) filtrate, by thin film evaporation to the every milliliter of suitable 4-5 of medicinal liquid gram crude drug, adds cold water to be diluted to every milliliter contained 1-3 gram, precipitates after 8-24 hour and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.05-1.2:1, lets cool to 80 ℃ hereinafter referred to as total solid;
(4) add the white sugar of total solid 2-5 times weight, the dextrin (preferably adding the dextrin of 0.9 times of weight) of 0.5-1.2 times of weight, with ethanol (65%), regulates humidity, use granulation machine granulation, packs.
The preparation method of above-mentioned electuary, preferably, step (1) is decocted 1-1.3 hour (preferably 1.2 hours) again.
The preparation method of above-mentioned electuary, preferably, step (1) precipitation is filtered (preferably 20 hours) after 18-23 hour.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, preferably, step (2) is evaporated to every milliliter of suitable crude drug 4.2-4.8 of medicinal liquid gram (preferably 4.5 grams).
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, preferably, step (2) precipitation is filtered (preferably 15 hours) after 13-18 hour.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, preferably, step (4) adds the white sugar (preferably 3.5 times) of total solid 3-4 times weight.
The present invention also provides the application of described electuary in the time of preparation treatment coronary atherosclerosis, myocardial infarction, myocardial necrosis, anginal medicine.
Instructions of taking: for making the present invention reach optimum efficiency, while taking, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Trichosanthis: sweetness and bitterness, cold.Cheng Wuji: " bitter in the mouth, cold.Enter lung, stomach, large intestine channel.Function cures mainly: lung moistening, reduce phlegm, and eliminating stagnation, intestine moistening.Control phlegm-heat cough, the thoracic obstruction, blocked-up chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle from the beginning of.
Herba Agerati Conyzoidis: pungent, micro-hardship, cool.Function cures mainly: expelling wind and clearing away heat, pain relieving, hemostasis, calculus.For upper respiratory tract infection, tonsillitis, pharyngolaryngitis, acute gastroenteritis, stomachache, stomachache, metrorrhagia, renal calculus, vesical calculus; Eczema is controlled in external, thrush, carbuncle pyogenic infections from tumour or sore, cellulitis, ulcer of the lower limb, otitis media, traumatic hemorrhage.
Ramulus Cinnamomi: nature and flavor: acrid, sweet, warm.Gui Jing: GUIXIN, lung, urinary bladder channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Cure mainly: for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Fructus Hippophae: another name Da Er, Fructus Elaeagni Angustifoliae, fructus hippophae, large Er Buxing, vinegar willow, acid thorn, sour Liu Liu, it examines a day Cannes, acid thorn, black thorn, yellow acid thorn, acid and sting, Fructus Hippophae and oil have very high medical value, can reduce cholesterol, cure the effects such as angina pectoris, prevent and treat in addition the effect of coronary atherosclerotic heart disease; Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis; Can treat gastric duodenal ulcer and dyspepsia etc., evident in efficacy to diseases such as chronic superficial gastritis, atrophic gastritis, colitis; Burn, scald, cutter burning, cold injury are had to good therapeutical effect; Cervical erosion is had to good therapeutic effect.Sour in the mouth; Puckery; Warm in nature, relieving cough and resolving phlegm; Invigorating the stomach and promoting digestion; Promoting blood circulation to remove blood stasis.Main cough with copious phlegm; Pulmonary abscess; Dyspepsia; Abdominal pain due to retention of food; Stomachache; Intestinal inflammation; Amenorrhea; Traumatic injury congestive edema.
Bulbus Allii Macrostemonis: nature and flavor: pungent, bitter, temperature.Gui Jing: return lung, stomach, large intestine channel.Effect: activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.Cure mainly: for thoracic obstruction pain, phlegm retention cough with asthma, lets out after dysentery heavy.
Cortex Mori: function cures mainly: dyspnea and cough due to lung-heat, diseases caused by retention of fluid stops lung, distension dyspnea with rapid respiration, especially kind purte the white and relieving asthma and cough, controls lung-heat cough with asthma, and expectorant is thick and yellow.The property of medicine: sweet in the mouth, micro-hardship, return lung, spleen channel.
Radix Salviae Miltiorrhizae: nature and flavor: hardship, is slightly cold.Gui Jing: GUIXIN, Liver Channel.Effect: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Cure mainly: for menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Mytilus: salty, temperature.Invigorating the liver and kidney, benefiting essence-blood, goiter disappears.Control asthenia weakness and emaciation, dizzy, night sweat, sexual impotence, lumbago, spits blood, metrorrhagia, leukorrhagia, goiter, hernia abdominal mass.Energy tonifying five ZANG-organs, Yiyang thing, reason waist beriberi, the dyspepsia that disappears, except cold air in abdomen, mass beside the umbilicus.
The Radix Stemonae: nature and flavor: sweet, bitter, tepor.Gui Jing: return lung meridian.Effect: nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cure mainly: cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outward for head louse, body louse, enterobiasis, pudendal pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.For deficiency of YIN chronic cough.
The Rhizoma Pinelliae: its acrid in the mouth, warm in nature, poisonous; Return spleen, stomach, lung meridian, medical value tuber is used as medicine, poisonous, energy drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the furuncle and phyma that disappears for life; Cure mainly cough with copious phlegm, nausea and vomiting; Acute mastitis, the dense property of acute and chronicization otitis media are controlled in external.Effect: humidifying expectorant, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness.Outer subduing inflammation., vomiting regurgitation dizzy for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, interior expectorant, breast gastral cavity painful abdominal mass are vexed, globus hystericus disease; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.
Polyporus: nature and flavor: sweet, light, flat.Gui Jing: return kidney, urinary bladder channel.Effect: promoting diuresis to eliminate damp pathogen.Cure mainly: for dysuria, edema, has loose bowels, stranguria with turbid discharge, leukorrhagia.
Rhizoma Alismatis: nature and flavor: sweet, cold.Gui Jing: return kidney, urinary bladder channel.Effect: diuresis, clearing away damp-heat.Cure mainly: for dysuria. edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.
Oletum Trogopterori: sweet, temperature.Promoting blood circulation to remove blood stasis, parch to black hemostasis.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black is controlled metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.
The invention provides electuary prescription science, the preparation method of various dosage forms is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1,selected materials is all Chinese medicine material, without any side effects;
2,this prescription meets Chinese medicine principle and coronary atherosclerosis patients body and mind feature completely, under the prerequisite of general principle, can have different prescriptions according to different crowd, function difference.
3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
The specific embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
embodiment 1the electuary for the treatment of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion (getting 10g for every part): Fructus Trichosanthis 6, Herba Agerati Conyzoidis 6, Ramulus Cinnamomi 6, Fructus Hippophae 2, Bulbus Allii Macrostemonis 6, Cortex Mori 3, Radix Salviae Miltiorrhizae 4, Mytilus 5, the Radix Stemonae 2, the Rhizoma Pinelliae 6, Polyporus 6, Rhizoma Alismatis 4, Oletum Trogopterori 3.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) crude drug of putting in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, decoct 0.8 hour again, filter extracting juice, medicine juice merges, to every milliliter contained 1-3 gram, add ethanol (95%) the limit edged of one times of weight to stir by thin film evaporation, precipitate after 15 hours and filter;
(2) filtrate, by thin film evaporation to every milliliter of suitable 4 grams of crude drugs of medicinal liquid, adds cold water to be diluted to every milliliter contained 1-3 gram, precipitates after 8 hours and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.05-1.2:1, lets cool to 80 ℃ hereinafter referred to as total solid;
(4) add the white sugar of 2 times of weight of total solid, the dextrin of 0.5 times of weight, with ethanol (65%), regulates humidity, use granulation machine granulation, packs.
model case one: an xx, male, 48 years old.Sensation of oppression over the chest with shortness of breath is had a surplus for 2 years, and it is uncomfortable in chest very serious that evening every day sleep is all felt, all cannot fall asleep normally, be afraid of cold, cardiopalmus, extremities being not warm is warm, and fatigue and weak, the lower limb soreness of waist that swells, the diseases such as chest pain radiating to the back.Remove examination in hospital, Color Sonography shows backflow, and exercise stress car is shown as the positive, and angiography is shown as arteriosclerosis, and doctor takes electuary of the present invention.
Take the present embodiment 3 gained electuaries, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of.Take 20 days, uncomfortable in chest, the symptom such as breathe hard obviously alleviates, and fatigue and weak also alleviates, and the amount of receiving increases, spirit can, take 2 months, angiography is shown as normally, following the service 4 months, malaise symptoms disappears, patient's self-induction is fully recovered.
embodiment 2the electuary for the treatment of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion (getting 15g for every part): Fructus Trichosanthis 9, Herba Agerati Conyzoidis 12, Ramulus Cinnamomi 10, Fructus Hippophae 8, Bulbus Allii Macrostemonis 15, Cortex Mori 6, Radix Salviae Miltiorrhizae 9, Mytilus 9, the Radix Stemonae 5, the Rhizoma Pinelliae 15, Polyporus 12, Rhizoma Alismatis 10, Oletum Trogopterori 9.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) crude drug of putting in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, decoct 1.4 hours again, filter extracting juice, medicine juice merges, to every milliliter contained 1-3 gram, add ethanol (95%) the limit edged of one times of weight to stir by thin film evaporation, precipitate after 25 hours and filter;
(2) filtrate, by thin film evaporation to every milliliter of suitable 5 grams of crude drugs of medicinal liquid, adds cold water to be diluted to every milliliter contained 1-3 gram, precipitates after 24 hours and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.05-1.2:1, lets cool to 80 ℃ hereinafter referred to as total solid;
(4) add the white sugar of 5 times of weight of total solid, the dextrin of 1.2 times of weight, with ethanol (65%), regulates humidity, use granulation machine granulation, packs.
embodiment 3the electuary for the treatment of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion (getting 25g for every part): Fructus Trichosanthis 7, Herba Agerati Conyzoidis 8, Ramulus Cinnamomi 7, Fructus Hippophae 4, Bulbus Allii Macrostemonis 9, Cortex Mori 4, Radix Salviae Miltiorrhizae 6, Mytilus 6, the Radix Stemonae 3, the Rhizoma Pinelliae 9, Polyporus 8, Rhizoma Alismatis 6, Oletum Trogopterori 5.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) crude drug of putting in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, decoct 1 hour again, filter extracting juice, medicine juice merges, to every milliliter contained 1-3 gram, add ethanol (95%) the limit edged of one times of weight to stir by thin film evaporation, precipitate after 18 hours and filter;
(2) filtrate, by thin film evaporation to every milliliter of suitable 4.2 grams of crude drugs of medicinal liquid, adds cold water to be diluted to every milliliter contained 1-3 gram, precipitates after 13 hours and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.05-1.2:1, lets cool to 80 ℃ hereinafter referred to as total solid;
(4) add the white sugar of 3 times of weight of total solid, the dextrin of 0.8 times of weight, with ethanol (65%), regulates humidity, use granulation machine granulation, packs.
model case two: Lu xx, age: 46 years old; Sex: women; Main suit: 3 months uncomfortable in chest of intermittent chest pain; History of present illness: patient occurred before 6 hours, without obvious inducement chest pain, for vexed pain after breastbone, being persistence, the radiation of companion's back part, without abdominal distention, without stomachache, without nausea and vomiting, generates heat without fear of cold, without cough and expectoration.Discuss: Color Sonography shows backflow, and exercise stress car is shown as the positive, and angiography is shown as arteriosclerosis.
Take the present embodiment 3 gained electuaries, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of.Take 20 days, chest pain is uncomfortable in chest obviously to be alleviated, and confusingly in the heart also alleviates, and the amount of receiving increases, spirit can, take 1 month, symptom is eliminated, the peace of sleeping night, vexed removing, strength increases, receive food can,, there is not any discomfort in following the service 2 months, the recovery from illness of patient's self-induction when patient takes.
embodiment 4the electuary for the treatment of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion (getting 5g for every part): Fructus Trichosanthis 8, Herba Agerati Conyzoidis 10, Ramulus Cinnamomi 9, Fructus Hippophae 6, Bulbus Allii Macrostemonis 12, Cortex Mori 5, Radix Salviae Miltiorrhizae 8, Mytilus 8, the Radix Stemonae 4, the Rhizoma Pinelliae 11, Polyporus 10, Rhizoma Alismatis 8, Oletum Trogopterori 7.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) crude drug of putting in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, decoct 1.3 hours again, filter extracting juice, medicine juice merges, to every milliliter contained 1-3 gram, add ethanol (95%) the limit edged of one times of weight to stir by thin film evaporation, precipitate after 23 hours and filter;
(2) filtrate, by thin film evaporation to every milliliter of suitable 4.8 grams of crude drugs of medicinal liquid, adds cold water to be diluted to every milliliter contained 1-3 gram, precipitates after 18 hours and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.05-1.2:1, lets cool to 80 ℃ hereinafter referred to as total solid;
(4) add the white sugar of 4 times of weight of total solid, the dextrin of 1 times of weight, with ethanol (65%), regulates humidity, use granulation machine granulation, packs.
model case three:yellow xx, 50 years old, man, occurs compared with more acutely and frequently angina pectoris in the past one day, the angina pectoris persistent period is longer, inducement is not obvious, but also uncomfortable in chest with the short time, the symptom of breathing hard, family members takes pills for curing heart disease to it and solves this symptom, but curative effect is bad, goes large hospital to do comprehensive inspection above-mentioned symptom and caused by coronary atherosclerosis.
Take the present embodiment 4 gained electuaries, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of.Take 10 days, uncomfortable in chest, angina pectoris obviously alleviates, and feels sick, symptoms of emesis disappears, and the amount of receiving increases, spirit can, take 20 days, the blood supply of electrocardio diagram coronary artery obviously improves, following the service 3 months, patient's recovery from illness.
embodiment 5the electuary for the treatment of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion (getting 20g for every part): Fructus Trichosanthis 7.5, Herba Agerati Conyzoidis 9, Ramulus Cinnamomi 8, Fructus Hippophae 5, Bulbus Allii Macrostemonis 10, Cortex Mori 4.5, Radix Salviae Miltiorrhizae 7, Mytilus 7, the Radix Stemonae 3.5, the Rhizoma Pinelliae 10, Polyporus 9, Rhizoma Alismatis 7, Oletum Trogopterori 6.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) crude drug of putting in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, decoct 1.2 hours again, filter extracting juice, medicine juice merges, to every milliliter contained 1-3 gram, add ethanol (95%) the limit edged of one times of weight to stir by thin film evaporation, precipitate after 20 hours and filter;
(2) filtrate, by thin film evaporation to every milliliter of suitable 4.5 grams of crude drugs of medicinal liquid, adds cold water to be diluted to every milliliter contained 1-3 gram, precipitates after 15 hours and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.05-1.2:1, lets cool to 80 ℃ hereinafter referred to as total solid;
(4) add the white sugar of 3.5 times of weight of total solid, the dextrin of 0.9 times of weight, with ethanol (65%), regulates humidity, use granulation machine granulation, packs.
test example 1the clinical practice of embodiment 5 gained treatment treatment coronary atherosclerosis electuaries: in June, 2010-2013 year December, screens 150 routine patients in 4 hospitals, wherein women's 100 examples, male's 50 examples, oldest 72 years old, minimal ages 38 years old, 55.2 years old mean age.Test 2 weeks before, carries out Continuous Observation to this crowd, records symptom and variation, be divided at random two groups, experimental group and matched group, experimental group is taken embodiment 5 products obtained therefroms, and matched group is taken other medicine (the conventional medicine such as metoprolol, lignocaine, norepinephrine).Using method is: each one bag, and every day 3 times, warm boiled water, 10 days courses for the treatment of.Curative effect situation criterion: cure: take a course for the treatment of of this product, the blood supply of electrocardio diagram coronary artery obviously improves, and malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: take a course for the treatment of of this product, electrocardio illustrates chronic coronary artery blood supply to be improved, and malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 38-72 year coronary atherosclerosis patients therapeutic outcomes
Table 1
Therapeutic effect: cure 95 examples (95%), effective percentage 98%.Successful is better than matched group.
During taking, self-induction symptom and physical change of spirit thereof are as shown in table 2.
Table 2:
The present invention selects Fructus Trichosanthis, Herba Agerati Conyzoidis, Ramulus Cinnamomi, Fructus Hippophae, Bulbus Allii Macrostemonis, Cortex Mori, Radix Salviae Miltiorrhizae etc. to carry out compatibility, makes after these drug regimens to produce synergism, and all medicines share, invigorate blood circulation and energy yin nourishing, blood stasis dispelling and just not hindering, has one's ideas straightened out and the QI invigorating of holding concurrently, therefore can obtain good therapeutic effect.Take 10 days, more than 53% feeling takes a turn for the better to some extent, and malaise symptoms improves; Take 20 days, more than 72% feeling takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 30 days, more than 97% feeling takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and coronarography shows that tremulous pulse is normal, the recovery from illness of some patients were self-induction.In experimental group, take more than 30 days, effective percentage can reach 93%, and matched group is only 76%.Electuary of the present invention has promoting blood circulation to restore menstrual flow, and scattered silt pain relieving effect has special curative effect to treatment atherosclerosis and coronary heart disease.
Claims (10)
1. the electuary for the treatment of coronary atherosclerosis, is characterized in that, is mainly prepared from by following bulk drugs, be weight portion: Fructus Trichosanthis 6-9, Herba Agerati Conyzoidis 6-12, Ramulus Cinnamomi 6-10, Fructus Hippophae 2-8, Bulbus Allii Macrostemonis 6-15, Cortex Mori 3-6, Radix Salviae Miltiorrhizae 4-9, Mytilus 5-9, Radix Stemonae 2-5, Rhizoma Pinelliae 6-15, Polyporus 6-12, Rhizoma Alismatis 4-10, Oletum Trogopterori 3-9.
2. the electuary of coronary atherosclerosis according to claim 1, is characterized in that, is mainly prepared from by following bulk drugs, be weight portion: Fructus Trichosanthis 7-8, Herba Agerati Conyzoidis 8-10, Ramulus Cinnamomi 7-9, Fructus Hippophae 4-6, Bulbus Allii Macrostemonis 9-12, Cortex Mori 4-5, Radix Salviae Miltiorrhizae 6-8, Mytilus 6-8, Radix Stemonae 3-4, Rhizoma Pinelliae 9-11, Polyporus 8-10, Rhizoma Alismatis 6-8, Oletum Trogopterori 5-7.
3. the electuary of coronary atherosclerosis according to claim 1, is characterized in that, is mainly prepared from by following bulk drugs, be weight portion: Fructus Trichosanthis 7.5, Herba Agerati Conyzoidis 9, Ramulus Cinnamomi 8, Fructus Hippophae 5, Bulbus Allii Macrostemonis 10, Cortex Mori 4.5, Radix Salviae Miltiorrhizae 7, Mytilus 7, the Radix Stemonae 3.5, the Rhizoma Pinelliae 10, Polyporus 9, Rhizoma Alismatis 7, Oletum Trogopterori 6.
4. according to the preparation method of the electuary of the arbitrary described treatment coronary atherosclerosis of claim 1-3, it is characterized in that, step is as follows:
(1) crude drug of putting in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, decoct 0.8-1.4 hour again, filter extracting juice, medicine juice merges, to every milliliter contained 1-3 gram, add ethanol (95%) the limit edged of one times of weight to stir by thin film evaporation, precipitate after 15-25 hour and filter;
(2) filtrate, by thin film evaporation to the every milliliter of suitable 4-5 of medicinal liquid gram crude drug, adds cold water to be diluted to every milliliter contained 1-3 gram, precipitates after 8-24 hour and filters;
(3) filtrate is by thin film evaporation to extractum shape, and concentrated solution specific gravity control is 1.05-1.2:1, lets cool to 80 ℃ hereinafter referred to as total solid;
(4) add the white sugar of total solid 2-5 times weight, the dextrin (preferably adding the dextrin of 0.9 times of weight) of 0.5-1.2 times of weight, with ethanol (65%), regulates humidity, use granulation machine granulation, packs.
5. preparation method according to claim 4, is characterized in that, step (1) is decocted 1-1.3 hour (preferably 1.2 hours) again.
6. preparation method according to claim 4, is characterized in that, step (1) precipitation is filtered (preferably 20 hours) after 18-23 hour.
7. preparation method according to claim 4, is characterized in that, step (2) is evaporated to every milliliter of suitable crude drug 4.2-4.8 of medicinal liquid gram (preferably 4.5 grams).
8. preparation method according to claim 4, is characterized in that, step (2) precipitation is filtered (preferably 15 hours) after 13-18 hour.
9. preparation method according to claim 4, is characterized in that, step (4) adds the white sugar (preferably 3.5 times) of total solid 3-4 times weight.
10. also provide the application in the time that coronary heart disease, myocardial infarction, myocardial necrosis, anginal medicine are treated in preparation according to the electuary of the arbitrary described treatment coronary atherosclerosis of claim 1-3.
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| CN201610164879.2A CN105687961A (en) | 2014-03-07 | 2014-03-07 | Preparation method of granule for treating coronary artery atherosclerosis |
| CN201610164887.7A CN105687962A (en) | 2014-03-07 | 2014-03-07 | Electuary capable of treating atherosclerosis of coronary artery and preparation method thereof |
| CN201410082159.2A CN103845670B (en) | 2014-03-07 | 2014-03-07 | Electuary and the preparation method for the treatment of coronary atherosclerosis |
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| CN201610164886.2A Division CN105770646A (en) | 2014-03-07 | 2014-03-07 | Electuary for treating coronary atherosclerosis |
| CN201610164879.2A Division CN105687961A (en) | 2014-03-07 | 2014-03-07 | Preparation method of granule for treating coronary artery atherosclerosis |
| CN201610164887.7A Division CN105687962A (en) | 2014-03-07 | 2014-03-07 | Electuary capable of treating atherosclerosis of coronary artery and preparation method thereof |
| CN201610164880.5A Division CN105816763A (en) | 2014-03-07 | 2014-03-07 | Preparation method of dissolved medicine for treating coronary arteriesarteriosclerosis |
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| CN104435659A (en) * | 2014-09-01 | 2015-03-25 | 周春美 | Traditional Chinese medicine tablet for treating coronary atherosclerotic heart disease and angina pectoris and preparation method of traditional Chinese medicine tablet |
| CN104922504A (en) * | 2015-05-29 | 2015-09-23 | 张慧玲 | Vinegar beverage for treating atherosclerosis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102078510A (en) * | 2011-01-24 | 2011-06-01 | 孙华清 | Chinese medicinal composition for treating coronary heart disease |
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| CN100441212C (en) * | 2005-01-12 | 2008-12-10 | 王振球 | Chinese medicine for treating cardiac failure |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102078510A (en) * | 2011-01-24 | 2011-06-01 | 孙华清 | Chinese medicinal composition for treating coronary heart disease |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435659A (en) * | 2014-09-01 | 2015-03-25 | 周春美 | Traditional Chinese medicine tablet for treating coronary atherosclerotic heart disease and angina pectoris and preparation method of traditional Chinese medicine tablet |
| CN104922504A (en) * | 2015-05-29 | 2015-09-23 | 张慧玲 | Vinegar beverage for treating atherosclerosis and preparation method thereof |
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| CN105687961A (en) | 2016-06-22 |
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