CN103845670B - Electuary and the preparation method for the treatment of coronary atherosclerosis - Google Patents

Electuary and the preparation method for the treatment of coronary atherosclerosis Download PDF

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CN103845670B
CN103845670B CN201410082159.2A CN201410082159A CN103845670B CN 103845670 B CN103845670 B CN 103845670B CN 201410082159 A CN201410082159 A CN 201410082159A CN 103845670 B CN103845670 B CN 103845670B
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electuary
tuber
treatment
weight
thin film
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CN103845670A (en
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徐瑞金
葛云洁
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Qingdao Municipal Hospital
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Qingdao Municipal Hospital
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Priority to CN201610164887.7A priority patent/CN105687962A/en
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Abstract

The invention discloses a kind of electuary for the treatment of coronary atherosclerosis, be mainly prepared from by following bulk drugs, be weight portion: Snakegourd Fruit 6-9, Ageratum conyzoides 6-12, cassia twig 6-10, sea-buckthorn 2-8, Longstamen Onion Bulb 6-15, mulberry skin 3-6, red sage root 4-9, mussel 5-9, tuber of stemona 2-5, tuber of pinellia 6-15, umbellate pore furgus 6-12, rhizoma alismatis 4-10, excrementum pteropi 3-9. Excellent results of the present invention also shows: selected materials is all traditional Chinese medicine material, without any side effects; This prescription meets traditional Chinese medicine principle and patients with coronary heart disease body and mind feature completely, under the prerequisite of general principle, can have different prescriptions according to different crowd, function difference, electuary of the present invention has activating blood to promote menstruation, and scattered silt pain relieving effect has special curative effect to treatment atherosclerotic and coronary heart disease.

Description

Electuary and the preparation method for the treatment of coronary atherosclerosis
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind for the treatment of coronary atherosclerosis electuary andIts preparation method.
Background technology
Atherosclerotic (Atherosclerosis) is type the most common and important in artery sclerosis, is characterized inThe inner membrance of artery of getting involved has the calmness of lipoids, the gathering of compound carbohydrate, and proliferation of fibrous tissue and calcific deposit then, and have arteryThe pathology in middle level. This disease is mainly involved large-scale and medium-sized flesh elastic-type artery, taking sustainer, coronary artery and cerebral artery as manySee, often cause obliteration or the tube wall serious consequence such as hemorrhage of breaking. The atherosclerotic occurring on coronary artery is calledCoronary atherosclerosis (CoronaryAtherosclerotic). It is modal stenosis coronary artery disease, spyIt not the atherosclerotic that the outer coronary artery of flesh wall props up. Coronary artery proximal section why start well pulse atherosclerosis be due toIt, thereby bears maximum systolic pressure and clashes into all near ventricle than all organ arteries. Moreover coronary arterial vessel tree is due to the heartDirty shape and have most directions to change, therefore also bears larger blood flow shear stress.
Predilection site: according to the postmortem statistics of China, total recall rate of pathology, Stenosis and average rank all withDescending anterior branch is the highest, and all the other are followed successively by right trunk, left trunk or LC, posterior descending branch. Gender differences: 20～50 years old pathology detectionRate, the male sex is significantly higher than women; Men and women's no significant difference after 60 years old.
Atherosclerotic is the basis that causes a series of hearts, cerebrovascular disease, and below we just come simply to tell aboutThe mechanism of atherogenesis. The low-density lipoprotein (Ox-LDL) of oxidation is atherosclerotic core, works as bloodIn low-density lipoprotein (LDL) making after by free-radical oxidations such as active oxygens (ROS) " low-density lipoprotein of oxidation " to be called for short" Ox-LDL ", he will intravasation wall, and 1.Ox-LDL damages the endothelial cell of vascular wall, and allows endothelial cell gap becomeGreatly; 2.Ox-LDL stimulates monocyte migration intravasation wall; 3.OX-LDL is by the smooth muscle cell of macrophage and blood vesselAcceptor engulf,----form foam cells, 4.Ox-LDL makes the downright bad disintegration of above-mentioned two kinds of foam cells, forms rotten congee sample badDead thing, AP forms.
Here to benly be that the low-density lipoprotein (Ox-LDL) of oxidation is in whole atherogenesis mistakeCheng Zhongqi central role, instead of we common people " low-density lipoprotein " or " blood fat " that it is generally acknowledged or " courage is solidAlcohol " concept, if LDL not oxidized be Ox-LDL, the monocyte of body thinks that LDL is " one of own side ", can be to he (LDL)Engulf and form foam cells, only having as he (LDL) and be oxidized to after Ox-LDL, just by inflammation such as the monocytes of bodyMedium is thought [dissident] composition, and it is engulfed, and eliminates, and finally forms foam cells. Therefore prevent that LDL is oxidized toOx-LDL is the atherosclerotic key point of containment, instead of our conventional reduction cholesterol of understanding, reduces blood fat, fallsLow low-density lipoprotein (LDL) etc.
Blood vessel after atherosclerotic, the formation of thrombus is the inflammatory process of a more complicated. Along with above-mentioned arteryThe growth of AP, is usually to cause above-mentioned foam cells death, forms gangrenosum acne core, what he can be with sustainable existenceInflammatory reaction, makes above-mentioned AP become very unstable, and the macrophage of activation is secreted a kind of enzyme degrade collagen fiberCap, unstable patch forms, and is so just easy to break. The substance release that patch after breaking highly causes blood coagulation in a large number enters blood vesselChamber, causes local thrombus to form. When this thrombosis is at the blood vessel of brain, be cerebral thrombus (cerebral infarction, cerebral infarction), work as brainBlood vessel is in a weak position and with hypertension and so on, or patch breaks and just formed cerebral hemorrhage outside blood vessel,This two classes situation traditional Chinese medical science apoplexy, doctor trained in Western medicine palsy; When this thrombosis is at the coronary artery of heart, be just myocardial infarction(miocardial infarction); When this thrombosis occurs in eyeground artery, it is exactly macular degeneration. When forming now of this thrombusWhen artery of lower extremity, just cause the change of foot disease of picture diabetes and so on.
Application publication number CN102973786A(application number 201210441546.1) Chinese patent literature discloseTreat a Chinese medicine for coronary atherosclerotic heart disease, made by the bulk drug of following weight parts: Radix Angelicae Sinensis 6-10 part,Pseudo-ginseng 3-5 part, radix scrophulariae 6-8 part, honeysuckle 12-15 part, radix cynanchi atrati 5-9 part, glossy ganoderma 14-18 part, lepidium seed 10-13 part,Root bark of white mulberry 8-10 part, dalbergia wood 6-8 part, corydalis tuber 10-12 part, Radix Codonopsis 15-20 part, Radix Glycyrrhizae 5-20 part, the tuber of dwarf lilyturf 15-20Part, magnetite 20-25 part. Application publication number CN103550624A(application number 201310524895.4) Chinese patent literary compositionOffer and disclose a kind of Chinese medicine preparation for the treatment of atherosclerotic and coronary atherosclerosis, its primary raw material and weight portion divideNot, 30 parts of Radix Angelicae Sinensis, 15 parts of rhizome of chuanxiongs, 18 parts of the root of herbaceous peonys, 30 parts, Fructus Hordei Germinatus, 12 parts, safflower, 12 parts of kelps, 10 parts of peppermints, ox30 parts of tongue grass, 30 parts of reed rhizomes.
In a word, in treatment, this has obtained good curative effect aspect sick to traditional Chinese medicine, but also has some problems: clinically to anti-Control coronary atherosclerosis and also need synchronous research, the malaise symptoms curative effect that treatment coronary atherosclerosis is occurred also needsIn further raising.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide that one is prepared simply, taking convenience, be easy to carry,The easily for a long time electuary of the treatment coronary atherosclerosis of clothes, this Chinese medicine composition determined curative effect and having no side effect.
Technical scheme of the present invention is:
The electuary for the treatment of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion: Snakegourd Fruit 6-9, Ageratum conyzoides 6-12, cassia twig 6-10, sea-buckthorn 2-8, Longstamen Onion Bulb 6-15, mulberry skin 3-6, red sage root 4-9, mussel 5-9, tuber of stemona 2-5, tuber of pinellia 6-15, umbellate pore furgus 6-12, rhizoma alismatis 4-10, excrementum pteropi 3-9.
The electuary of foregoing treatment coronary atherosclerosis, preferably, mainly prepared by following bulk drugs andBecome, be weight portion: Snakegourd Fruit 7-8, Ageratum conyzoides 8-10, cassia twig 7-9, sea-buckthorn 4-6, Longstamen Onion Bulb 9-12, mulberry skin 4-5, red sage root 6-8 is lightDish 6-8, tuber of stemona 3-4, tuber of pinellia 9-11, umbellate pore furgus 8-10, rhizoma alismatis 6-8, excrementum pteropi 5-7.
The electuary of foregoing treatment coronary atherosclerosis, more preferably good, mainly by following bulk drugs systemStandby forming, is weight portion: Snakegourd Fruit 7.5, Ageratum conyzoides 9, cassia twig 8, sea-buckthorn 5, Longstamen Onion Bulb 10, mulberry skin 4.5, the red sage root 7, mussel 7, the tuber of stemona3.5, the tuber of pinellia 10, umbellate pore furgus 9, rhizoma alismatis 7, excrementum pteropi 6.
The preparation method of the electuary of described treatment coronary atherosclerosis is:
(1) bulk drug put in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, then decoct 0.8-1.4 hour, mistakeLeaching juice, concoction merges, and to every milliliter contained 1-3 gram, adds ethanol (95%) the limit edged of one times of weight to stir by thin film evaporationMix, precipitate after 15-25 hour and filter;
(2) filtrate, by thin film evaporation to the every milliliter of suitable 4-5 of liquid gram crude drug, adds cold water to be diluted to every milliliter contained1-3 gram, precipitates after 8-24 hour and filters;
(3) filtrate is by thin film evaporation to medicinal extract shape, and concentrate specific gravity control is 1.05-1.2:1, let cool to 80 DEG C hereinafter referred to asTotal solid;
(4) add the white granulated sugar of total solid 2-5 times weight, the dextrin of 0.5-1.2 times of weight (preferably adds 0.9 times of weightDextrin), with ethanol (65%), regulate humidity, use granulator granulation, pack.
The preparation method of above-mentioned electuary, preferably, step (1) is decocted 1-1.3 hour (preferably 1.2 hours) again.
The preparation method of above-mentioned electuary, preferably, step (1) precipitation is filtered (preferably 20 hours) after 18-23 hour.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, preferably, step (2) is evaporated to every milliliterThe suitable crude drug 4.2-4.8 of liquid gram (preferably 4.5 grams).
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, preferably, 13-18 is little for step (2) precipitationTime after filter (preferably 15 hours).
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, preferably, step (4) adds total solid 3-The white granulated sugar (preferably 3.5 times) of 4 times of weight.
The present invention also provides described electuary at preparation treatment coronary atherosclerosis, miocardial infarction, myocardial necrosis, the heartThe application when medicine of angina.
Instructions of taking: for making the present invention reach optimum efficiency, while taking, each one bag, every day 3 times, warm boiled water, 10It course for the treatment of.
The pharmacology of the present invention's main Chinese medicine material used is as follows:
Snakegourd Fruit: sweetness and bitterness, cold. Cheng Wuji: " bitter, cold. Enter lung, stomach, large intestine channel. Function cures mainly: moistening lung, reduce phlegm, and dissipating bind,Ease constipation. Control phlegm-heat cough, the obstruction of qi in the chest, accumulation of pathogens in chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle swollen from the beginning of.
Ageratum conyzoides: pungent, micro-hardship, cool. Function cures mainly: expelling wind and clearing away heat, pain relieving, hemostasis, row's stone. For the infection of the upper respiratory tract,Tonsillitis, sphagitis, acute gastroenteritis, stomachache, stomachache, uterine bleeding, kidney stone, vesical calculus; Eczema is controlled in external application, thrush,Carbuncle pyogenic infections from tumour or sore, cellulitis, the ulcer of lower limb, tympanitis, traumatism and bleeding.
Cassia twig: nature and flavor: acrid, sweet, warm. Gui Jing: the thoughts of returning home, lung, urinary bladder channel. Effect: sweating expelling pathogenic factors from muscles and skin, warming meridian is supporing yangChange gas, the flat gas that spins. Cure mainly: for anemofrigid cold, coldness and pain in the epigastrium, blood is cold through closing, joint pain, phlegm and retained fluid, oedema, palpitaition, runs quicklyGlobefish.
Sea-buckthorn: another name Da Er, arrow-leaved oleaster, fructus hippophae, large Er Buxing, vinegar willow, acid thorn, sour Liu Liu, its examine a day Cannes, acid sting,Black thorn, yellow acid thorn, acid thorn thorn, fructus hippophae and oil have very high medical value, can reduce cholesterol, cure the works such as angina pectorisWith, prevent and treat in addition the effect of coronary atherosclerotic heart disease; Have and eliminate the phlegm, cough-relieving, relieving asthma and treat chronic bronchitisEffect; Can treat gastric duodenal ulcer and indigestion etc., to chronic superficial gastritis, atrophic gastritis, colitisEvident in efficacy etc. illness; Burn, scald, cutter burning, frostbite are had to good therapeutic action; Cervical erosion is had to good controllingTherapeutic effect. Taste acid; Puckery; Warm in nature, relieving cough and reducing sputum; Stomach strengthening and digestion promoting; Promoting blood circulation to remove blood stasis. Main coughing with a lot of sputum; Pulmonary abscess; Indigestion; FoodLong-pending stomachache; Stomachache; Enteritis; Amenorrhoea; Fall dozen stasis of blood swollen.
Longstamen Onion Bulb: nature and flavor: pungent, bitter, temperature. Gui Jing: return lung, stomach, large intestine channel. Effect: activate yang and remove abstruction, promoting the circulation of qi is led stagnant. MainControl: for obstruction of qi in the chest pain, phlegm and retained fluid is coughed and breathed heavily, let out after dysentery heavy.
Mulberry skin: function cures mainly: dyspnea and cough due to lung-heat, water drink stops lung, and turgor is breathed heavily urgency, and especially kind purte the white and relieving asthma and cough is controlled lung heat and is coughedBreathe heavily, phlegm is thick and yellow. The property of medicine: sweet, the micro-hardship of taste, return lung, the spleen channel.
The red sage root: nature and flavor: hardship, is slightly cold. Gui Jing: the thoughts of returning home, Liver Channel. Effect: stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire. MainControl: for irregular menstruation, through closing dysmenorrhoea ， lumps in the chest and abdomen, chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia; Liver spleen is swollenGreatly, angina pectoris.
Mussel: salty, temperature. Filling liver kidney, benefiting essence-blood, goiter and tumor disappears. Control consumptive disease thin thin, dizzy, night sweat, impotence, pain in the back, spits blood,Uterine bleeding, under band, goiter and tumor, hernia lump in the abdomen. Energy tonifying five zang organs, Yiyang thing, reason waist beriberi, the place food that disappears, except cold air in abdomen, Xuan addiction.
The tuber of stemona: nature and flavor: sweet, bitter, tepor. Gui Jing: return lung channel. Effect: moistening lung to lower qi cough-relieving, desinsection. Cure mainly: for for a long time newCough, pulmonary tuberculosis cough, pertussis; Outward for head louse, body louse, enterobiasis, pruritus vulvae. The honey tuber of stemona moistens the lung and relieve the cough. Cough for deficiency of Yin labor.
The tuber of pinellia: its taste is pungent, warm in nature, poisonous; Return spleen, stomach, lung channel, medical value stem tuber is used as medicine, poisonous, can be eliminating dampness and eliminating phlegm,Stopping nausea and vomiting by lowering the adverse flow of QI, raw with the furuncle that disappears; Cure mainly coughing with a lot of sputum, n and V; Acute mastitis, the dense property of acute and chronicization middle ear are controlled in external applicationScorching. Effect: humidifying phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass. Control wet phlegm cold drink, vomiting, gastric disorder causing nausea, coughs that to breathe heavily phlegm many, chest diaphragm turgor,Coma due to blocking of the respiratory system headache, dizzy egersis. Outer subduing inflammation. Cough for phlegm more breathe heavily, phlegm and retained fluid is dizzyly throbbed with fear, interior phlegm is dizzy, vomiting gastric disorder causing nausea, chest gastral cavity ruffian are vexed,Globus hysteriocus disease; Raw with controlling the swollen subcutaneous nodule of carbuncle outward. Pinellia is used for stopping nausea and vomiting by lowering the adverse flow of QI.
Umbellate pore furgus: nature and flavor: sweet, light, flat. Gui Jing: return kidney, urinary bladder channel. Effect: clearing damp and promoting diuresis. Cure mainly: for difficult urination,Oedema, has loose bowels, and stranguria with turbid discharge, under band.
Rhizoma alismatis: nature and flavor: sweet, cold. Gui Jing: return kidney, urinary bladder channel. Effect: diuresis, clearing away damp-heat. Cure mainly: for urine notProfit. oedema turgor, the oliguria of having loose bowels, phlegmatic vertigo, heat is drenched puckery pain; High fat of blood.
Excrementum pteropi: sweet, temperature. Promoting blood circulation to remove blood stasis, fries charcoal hemostasis. Have a pain for trusted subordinate's extravasated blood, dysmenorrhoea, blood stasis is through closing, and become silted up postpartumHemoperitoneum pain; Fry charcoal and control metrostaxis; Traumatic injury is controlled in external application, snake, insect bite wound.
The invention provides electuary prescription science, the preparation method of various formulations is simple, products obtained therefrom taking convenience, is convenient to takeBand. In addition, excellent results of the present invention also shows:
1, selected materials is all traditional Chinese medicine material, without any side effects;
2, this prescription meets traditional Chinese medicine principle and coronary atherosclerosis patients body and mind feature completely, before general principlePut, can have different prescriptions according to different crowd, function difference.
3, medicine source is easy to get, and medicinal material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
Embodiment 1 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weightPart (getting 10g for every part): Snakegourd Fruit 6, Ageratum conyzoides 6, cassia twig 6, sea-buckthorn 2, Longstamen Onion Bulb 6, mulberry skin 3, the red sage root 4, mussel 5, the tuber of stemona 2, the tuber of pinellia 6,Umbellate pore furgus 6, rhizoma alismatis 4, excrementum pteropi 3.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) bulk drug put in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, then decoct 0.8 hour, cross leachingJuice, concoction merges, and to every milliliter contained 1-3 gram, adds ethanol (95%) the limit edged of one times of weight to stir by thin film evaporation,Precipitate after 15 hours and filter;
(2) filtrate, by thin film evaporation to every milliliter of suitable 4 grams of crude drugs of liquid, adds cold water to be diluted to every milliliter contained 1-3 grams, precipitate after 8 hours and filter;
(3) filtrate is by thin film evaporation to medicinal extract shape, and concentrate specific gravity control is 1.05-1.2:1, let cool to 80 DEG C hereinafter referred to asTotal solid;
(4) add the white granulated sugar of 2 times of weight of total solid, the dextrin of 0.5 times of weight, with ethanol (65%), regulates humidity,Use granulator granulation, packaging.
Model case one a: xx, the male sex, 48 years old. Uncomfortable in chest breathing hard had a surplus for 2 years, and evening every day, sleep all felt very uncomfortable in chestSeverity, all cannot fall asleep normally, is afraid of cold, palpitaition, four limbs owes warm, and fatigue and weak, the leg soreness of waist that swells, the diseases such as chest pain radiating to the back. GoExamination in hospital, Color Sonography shows backflow, and exercise stress car is shown as the positive, and angiography is shown as artery sclerosis, doctorTake electuary of the present invention.
Take the present embodiment 3 gained electuaries, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of. Take 20My god, uncomfortable in chest, the symptom such as breathe hard obviously alleviates, fatigue and weak also alleviates, the amount of receiving increases, spirit can, take 2 months, angiography is aobviousBe shown normally, following the service 4 months, malaise symptoms disappears, the recovery from illness of patient's self-induction.
Embodiment 2 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion(getting 15g for every part): Snakegourd Fruit 9, Ageratum conyzoides 12, cassia twig 10, sea-buckthorn 8, Longstamen Onion Bulb 15, mulberry skin 6, the red sage root 9, mussel 9, the tuber of stemona 5, the tuber of pinellia15, umbellate pore furgus 12, rhizoma alismatis 10, excrementum pteropi 9.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) bulk drug put in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, then decoct 1.4 hours, cross leachingJuice, concoction merges, and to every milliliter contained 1-3 gram, adds ethanol (95%) the limit edged of one times of weight to stir by thin film evaporation,Precipitate after 25 hours and filter;
(2) filtrate, by thin film evaporation to every milliliter of suitable 5 grams of crude drugs of liquid, adds cold water to be diluted to every milliliter contained 1-3 grams, precipitate after 24 hours and filter;
(3) filtrate is by thin film evaporation to medicinal extract shape, and concentrate specific gravity control is 1.05-1.2:1, let cool to 80 DEG C hereinafter referred to asTotal solid;
(4) add the white granulated sugar of 5 times of weight of total solid, the dextrin of 1.2 times of weight, with ethanol (65%), regulates humidity,Use granulator granulation, packaging.
Embodiment 3 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weight portion(getting 25g for every part): Snakegourd Fruit 7, Ageratum conyzoides 8, cassia twig 7, sea-buckthorn 4, Longstamen Onion Bulb 9, mulberry skin 4, the red sage root 6, mussel 6, the tuber of stemona 3, the tuber of pinellia 9, pigSiberian cocklebur 8, rhizoma alismatis 6, excrementum pteropi 5.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) bulk drug put in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, then decoct 1 hour, cross leaching juice,Concoction merges, and to every milliliter contained 1-3 gram, adds ethanol (95%) the limit edged of one times of weight to stir, precipitation by thin film evaporationAfter 18 hours, filter;
(2) filtrate, by thin film evaporation to every milliliter of suitable 4.2 grams of crude drugs of liquid, adds cold water to be diluted to every milliliter contained1-3 gram, precipitates after 13 hours and filters;
(3) filtrate is by thin film evaporation to medicinal extract shape, and concentrate specific gravity control is 1.05-1.2:1, let cool to 80 DEG C hereinafter referred to asTotal solid;
(4) add the white granulated sugar of 3 times of weight of total solid, the dextrin of 0.8 times of weight, with ethanol (65%), regulates humidity,Use granulator granulation, packaging.
Model case two: Lu xx, age: 46 years old; Sex: women; Main suit: 3 months uncomfortable in chest of intermittent pectoralgia; Present illness history:Patient occurred before 6 hours, without obvious inducement pectoralgia, for vexed pain after breastbone, being continuation, and the radiation of companion's back part, without abdominal distension, without abdomenBitterly, without n and V, without chilly heating, without cough and expectoration. Discuss: Color Sonography shows backflow, and exercise stress car is shown asThe positive, angiography is shown as artery sclerosis.
Take the present embodiment 3 gained electuaries, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of. Take 20My god, pectoralgia is uncomfortable in chest obviously to be alleviated, and confusingly in the heart also alleviates, the amount of receiving increases, spirit can, take 1 month, symptom is eliminated, the peace of sleeping night, the heartTired removing, strength increases, receive food can,, there is not any discomfort in following the service 2 months, the recovery from illness of patient's self-induction when patient takes.
Embodiment 4 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weightPart (getting 5g for every part): Snakegourd Fruit 8, Ageratum conyzoides 10, cassia twig 9, sea-buckthorn 6, Longstamen Onion Bulb 12, mulberry skin 5, the red sage root 8, mussel 8, the tuber of stemona 4, the tuber of pinellia11, umbellate pore furgus 10, rhizoma alismatis 8, excrementum pteropi 7.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) bulk drug put in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, then decoct 1.3 hours, cross leachingJuice, concoction merges, and to every milliliter contained 1-3 gram, adds ethanol (95%) the limit edged of one times of weight to stir by thin film evaporation,Precipitate after 23 hours and filter;
(2) filtrate, by thin film evaporation to every milliliter of suitable 4.8 grams of crude drugs of liquid, adds cold water to be diluted to every milliliter contained1-3 gram, precipitates after 18 hours and filters;
(3) filtrate is by thin film evaporation to medicinal extract shape, and concentrate specific gravity control is 1.05-1.2:1, let cool to 80 DEG C hereinafter referred to asTotal solid;
(4) add the white granulated sugar of 4 times of weight of total solid, the dextrin of 1 times of weight, with ethanol (65%), regulates humidity, usesGranulator granulation, packaging.
Model case three: yellow xx, 50 years old, man, occurred that one day angina pectoris is held compared with more violent and frequently angina pectoris in the pastThe continuous time is longer, and inducement is not obvious, but also uncomfortable in chest with the short time, the symptom of breathing hard, family members takes and rescues the heart to itBall solves this symptom, but curative effect is bad, and going large hospital to do comprehensive inspection above-mentioned symptom is to be drawn by coronary atherosclerosisRise.
Take the present embodiment 4 gained electuaries, each one bag, every day 3 times, warm boiled water, 10 days courses for the treatment of. Take 10My god, uncomfortable in chest, angina pectoris obviously alleviates, and feels sick, symptoms of emesis disappears, the amount of receiving increases, spirit can, take 20 days, electrocardio diagram is crownArtery blood supply obviously improves, following the service 3 months, patient's recovery from illness.
Embodiment 5 treats the electuary of coronary atherosclerosis, is mainly prepared from by following bulk drugs, is weightPart (getting 20g for every part): Snakegourd Fruit 7.5, Ageratum conyzoides 9, cassia twig 8, sea-buckthorn 5, Longstamen Onion Bulb 10, mulberry skin 4.5, the red sage root 7, mussel 7, the tuber of stemona 3.5,The tuber of pinellia 10, umbellate pore furgus 9, rhizoma alismatis 7, excrementum pteropi 6.
The preparation method of the electuary of above-mentioned treatment coronary atherosclerosis, step is:
(1) bulk drug put in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, then decoct 1.2 hours, cross leachingJuice, concoction merges, and to every milliliter contained 1-3 gram, adds ethanol (95%) the limit edged of one times of weight to stir by thin film evaporation,Precipitate after 20 hours and filter;
(2) filtrate, by thin film evaporation to every milliliter of suitable 4.5 grams of crude drugs of liquid, adds cold water to be diluted to every milliliter contained1-3 gram, precipitates after 15 hours and filters;
(3) filtrate is by thin film evaporation to medicinal extract shape, and concentrate specific gravity control is 1.05-1.2:1, let cool to 80 DEG C hereinafter referred to asTotal solid;
(4) add the white granulated sugar of 3.5 times of weight of total solid, the dextrin of 0.9 times of weight, with ethanol (65%), regulates dry wetDegree, uses granulator granulation, packaging.
The clinical practice of test example 1 embodiment 5 gained treatment treatment coronary atherosclerosis electuaries: in June, 2010-In December, 2013, screen 150 routine patients in 4 hospitals, wherein women's 100 examples, the male sex's 50 examples, oldest 72 years old, minimum38 years old age, 55.2 years old mean age. Test 2 weeks before, carries out Continuous Observation to this crowd, records symptom and variation, randomBe divided into two groups, experimental group and control group, experimental group is taken embodiment 5 products obtained therefroms, and control group is taken other medicine (Mei TuoluoThe conventional medicines such as that, lidocaine, norepinephrine). Using method is: each one bag, and every day 3 times, warm boiled water, 10It course for the treatment of. Curative effect situation criterion: cure: take a course for the treatment of of this product, the blood supply of electrocardio diagram coronary artery obviously changesKind, malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: take a course for the treatment of of this product, electrocardio illustrates chronic coronary arteryBlood supply improves, and malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: to take a course for the treatment of of this product, malaise symptomsUnchanged. Result is as shown in table 1.
Table 1: take embodiment 5 product 38-72 year coronary atherosclerosis patients treatment results
Table 1
Result for the treatment of: cure 95 examples (95%), efficient 98%. Successful is better than control group.
During taking, self-induction symptom and muscle power spirit thereof change as shown in table 2.
Table 2:
The present invention selects Snakegourd Fruit, Ageratum conyzoides, cassia twig, sea-buckthorn, Longstamen Onion Bulb, mulberry skin, the red sage root etc. to carry out compatibility, makes these medicinesAfter combination, produce synergy, all medicines share, and invigorate blood circulation and can yin-nourishing, dispel the stasis of blood and just do not hinder, and have one's ideas straightened out and the beneficial gas of holding concurrently, therefore can obtain goodGood result for the treatment of. Take 10 days, more than 53% feeling takes a turn for the better to some extent, and malaise symptoms improves; Take more than 72% sense 20 daysTo taking a turn for the better to some extent, malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 30 days, more than 97% feeling takes a turn for the better to some extent, noSuitable symptom is improved or is disappeared, and spirit, muscle power strengthen, and coronarography shows that artery is normal, the recovery from illness of some patients were self-induction. ExperimentIn group, take more than 30 days, efficiently reach 93%, and control group is only 76%. Electuary of the present invention has activating blood to promote menstruation, looseSilt pain relieving effect, has special curative effect to treatment atherosclerotic and coronary heart disease.

Claims (1)

1. the preparation method of the electuary for the treatment of coronary atherosclerosis, is characterized in that, gets following bulk drugs, is weight portion:Snakegourd Fruit 7.5, Ageratum conyzoides 9, cassia twig 8, sea-buckthorn 5, Longstamen Onion Bulb 10, mulberry skin 4.5, the red sage root 7, mussel 7, the tuber of stemona 3.5, the tuber of pinellia 10, umbellate pore furgus 9,Rhizoma alismatis 7, excrementum pteropi 6; Step is:
(1) bulk drug put in order is mixed and decocts juice, decoct altogether three times, at every turn after water boils, then decoct 1.2 hours, cross leaching juice, medicineJuice merges, and to every milliliter contained 1-3 gram, adds 95% ethanol of one times of weight by thin film evaporation, and limit edged stirs, precipitation 20After hour, filter;
(2) filtrate, by thin film evaporation to every milliliter of suitable 4.5 grams of crude drugs of liquid, adds cold water to be diluted to every milliliter contained 1-3Gram, precipitate after 15 hours and filter;
(3) filtrate is by thin film evaporation to medicinal extract shape, and concentrate specific gravity control is 1.05-1.2:1, lets cool to 80 DEG C hereinafter referred to as total solidThe scale of construction;
(4) add the white granulated sugar of 3.5 times of weight of total solid, the dextrin of 0.9 times of weight, uses 65% ethanol, regulates humidity, withGrain machine granulation, packaging.
CN201410082159.2A 2014-03-07 2014-03-07 Electuary and the preparation method for the treatment of coronary atherosclerosis Expired - Fee Related CN103845670B (en)

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