CN107898988A - A kind of Chinese medicine composition for treating chronic cardiopulmonary disease and preparation method thereof - Google Patents

A kind of Chinese medicine composition for treating chronic cardiopulmonary disease and preparation method thereof Download PDF

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CN107898988A
CN107898988A CN201711302574.4A CN201711302574A CN107898988A CN 107898988 A CN107898988 A CN 107898988A CN 201711302574 A CN201711302574 A CN 201711302574A CN 107898988 A CN107898988 A CN 107898988A
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medicine composition
chinese medicine
radix
chinese
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代立新
代哲尘
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Tangyin County Red Star Biology Co Ltd
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Abstract

The invention discloses a kind of Chinese medicine composition for treating chronic cardiopulmonary disease and preparation method thereof, it is characterised in that the Chinese medicine composition is made of the raw material of following parts by weight:20 30 parts of red ginseng, 10 15 parts of radix astragali, 15 20 parts of Schisandra chinensis, 20 30 parts of keel, 20 30 parts of oyster, 15 20 parts of jujube kernel, 15 20 parts of rhizoma atractylodis macrocephalae, 10 15 parts of Poria cocos, 10 15 parts of Chinese yam, 10 15 parts of rhizoma zingiberis, 10 15 parts of agalloch eaglewood, 15 25 parts of psoralea corylifolia, 10 15 parts of radix cyathulae, 10 15 parts of Semen Cuscutae, 69 parts of radix glycyrrhizae, the present invention is to reinforce vital energy, veins takes off admittedly, the red ginseng of nourishing qi to stop is monarch drug in a prescription;Using radix astragali, Schisandra chinensis as ministerial drug;Using keel, oyster, jujube kernel, rhizoma atractylodis macrocephalae, Poria cocos, Chinese yam, rhizoma zingiberis, agalloch eaglewood, psoralea corylifolia, radix cyathulae, Semen Cuscutae as adjutant;Using radix glycyrrhizae to make medicine.Compatibility is reasonable, has no toxic side effect, and can fundamentally treat chronic cardiopulmonary disease, quick, short treating period, will not cultivate the drug resistance of bacterium, cheap.

Description

A kind of Chinese medicine composition for treating chronic cardiopulmonary disease and preparation method thereof
Technical field
Patent of the present invention is related to a kind of Chinese medicine, especially a kind of Chinese medicine composition for treating chronic cardiopulmonary disease and its preparation side Method, belongs to technical field of traditional Chinese medicines.
Background technology
Chronic cor pulmonale (abbreviation pulmonary heart disease) is due to that chronic bronchial, lung, thorax or pulmonary arterial vascular are chronic Pulmonary vascular resistance increase, pulmonary hypertension caused by lesion and then make Right ventricular hypertrophy, expand, companion or not with right heart function exhaustion Heart disease.Acute cor pulmonale mainly by main pulmonary artery or the unexpected embolism of its Main Branches, the big portion of pulmonary circulation by Resistance, so that pulmonary arterial pressure drastically increases, acute right ventricles are expanded and the heart disease of right ventricular function exhaustion.By the compensatory of its function It is following two that phase carries out division with Decompensated stage:1st, lung, cardiac functional compensatory period (including paracmasis) this phase are mainly chronic resistance The performance of plug property lung disease (abbreviation chronic obstructive pulmonary disease).Chronic cough, expectoration, out of breath, palpitaition, expiratory dyspnea, weak and labor after activity Dynamic endurance declines.Physical examination can have obvious pulmonary emphysema to levy, auscultation diminished breath sound, occasionally there is a dry, moist rales, the slight oedema of lower limb, Afternoon is obvious, and secondary morning disappears.Border of cardiac dullness often is not easy to kowtow out because of pulmonary emphysema.Heart sound is remote, but pulmonary area can have second The accentuation of cardiac sound, prompts have pulmonary hypertension.There is systolic murmur or xiphoid-process heartbeat shown below in tricuspid valve area, and more promptings have the right side The heart is plump, expands.Some cases hinder Vena cava return, it is seen that jugular vein fills because pulmonary emphysema raise intrapleural pressure.Again Because diaphragm declines, the liver upper bound and lower edge is set significantly to move down.2nd, lung, (including Acute Exacerbation Period) current period cardiac functional decompensatory period are clinical Mainly show based on respiratory failure, with or without heart failure.Since the harm of pulmonary heart disease later stage is bigger, can trigger many concurrent Disease, at present treatment mainly take doctor trained in Western medicine and physical therapy, take Western medicine for long periods of time and are also easy to produce the drug resistance of germ and are unfavorable for the later stage Treatment, though physical therapy has body the stimulation of very little, can not be effected a radical cure.
It is immune that studying data at home and abroad confirms no matter aged patients with cor pulmonale exists in acute attack stage or paracmasis Hypofunction.Due to immunologic hypofunction, prolonged and repeated airway infections, treat successful key and are that timely and effective control is acute Stage of attack, and control the key of acute attack stage to be infection control, so usually based on antibiosis extract for treating, but antibiotic Often make bacterial resistance, flora imbalance, side effect is more or killed microorganism destroys, and discharges substantial amounts of ribonucleic acid, makes Thick sputum is not easy cough and removes, and bacterium constantly breeds, and antibacterial therapy tends not to reach preferable therapeutic effect.Moreover, chronic pulmonary Worry is common disease, frequently-occurring disease in China, and average illness rate is 0.48%, chronic cardiopulmonary disease in the course of disease often because it is various it is acute simultaneously Send out disease and go to a doctor and be in hospital repeatedly.The common heart failure of chronic cor pulmonale, pulmonary infection, respiratory failure, lung brain The complication such as disease and arrhythmia cordis, shock, disseminated intravascular coagulation, upper gastrointestinal bleeding, multiple organ dysfunction.Due to controlling To treat and be unsatisfied with, chronic cardiopulmonary disease case fatality rate is very high, and average 30% or so.The lung-distension is divided into type of retention of turbid phlegm in the lung, the strongly fragrant lung of phlegm heat by the traditional Chinese medical science Type, type of water overflowing caused by insuffi ciency of YANG and asthenia of pulmonosplenic qi type, by diagnosis and treatment, treatment of the reasonable formula to pulmonary heart disease is incomparable with doctor trained in Western medicine Advantage, and toxic side effect is small.So for existing pathomechanism and principle-method-recipe-medicines, need to be further improved understanding, change Into the Chinese medicine composition with perfect treatment chronic cardiopulmonary disease.
The content of the invention
For the problems of the prior art, the invention aims to provide a kind of Chinese traditional medicine composition for treating chronic cardiopulmonary disease Thing and preparation method thereof, the Chinese medicine composition prepared by this method is safe and reliable, has no toxic side effect, quick, cheap, With reference to monarch make up a prescription mechanism carry out compatibility, to chronic cardiopulmonary disease have it is fine the effect of.
In order to achieve the above object, the technical scheme is that:
A kind of Chinese medicine composition for treating chronic cardiopulmonary disease, it is characterised in that the Chinese medicine composition by following parts by weight original Material composition:20-30 parts of red ginseng, 10-15 parts of radix astragali, 15-20 parts of Schisandra chinensis, 20-30 parts of keel, 20-30 parts of oyster, jujube kernel 15- 20 parts, 15-20 parts of rhizoma atractylodis macrocephalae, 10-15 parts of Poria cocos, 10-15 parts of Chinese yam, 10-15 parts of rhizoma zingiberis, 10-15 parts of agalloch eaglewood, psoralea corylifolia 15- 25 parts, 10-15 parts of radix cyathulae, 10-15 parts of Semen Cuscutae, 6-9 parts of radix glycyrrhizae.
Preferably, which is made of the raw material of following parts by weight:22 parts of red ginseng, 11 parts of radix astragali, the five tastes 16 parts of son, 22 parts of keel, 22 parts of oyster, 16 parts of jujube kernel, 16 parts of rhizoma atractylodis macrocephalae, 11 parts of Poria cocos, 11 parts of Chinese yam, 11 parts of rhizoma zingiberis, agalloch eaglewood 11 parts, 16 parts of psoralea corylifolia, 11 parts of radix cyathulae, 11 parts of Semen Cuscutae, 7 parts of radix glycyrrhizae.
Preferably, which is made of the raw material of following parts by weight:25 parts of red ginseng, 13 parts of radix astragali, the five tastes 27 parts of son, 25 parts of keel, 25 parts of oyster, 17 parts of jujube kernel, 17 parts of rhizoma atractylodis macrocephalae, 13 parts of Poria cocos, 13 parts of Chinese yam, 13 parts of rhizoma zingiberis, agalloch eaglewood 13 parts, 20 parts of psoralea corylifolia, 13 parts of radix cyathulae, 13 parts of Semen Cuscutae, 8 parts of radix glycyrrhizae.
Preferably, which is made of the raw material of following parts by weight:28 parts of red ginseng, 14 parts of radix astragali, the five tastes 18 parts of son, 28 parts of keel, 28 parts of oyster, 18 parts of jujube kernel, 18 parts of rhizoma atractylodis macrocephalae, 14 parts of Poria cocos, 14 parts of Chinese yam, 14 parts of rhizoma zingiberis, agalloch eaglewood 14 parts, 24 parts of psoralea corylifolia, 14 parts of radix cyathulae, 14 parts of Semen Cuscutae, 8 parts of radix glycyrrhizae.
Invention also provides a kind of preparation method of the Chinese medicine composition for the treatment of chronic cardiopulmonary disease as described above, its It is characterized in that the preparation method includes the following steps:
1), weigh by weight red ginseng, radix astragali, Schisandra chinensis, keel, oyster, jujube kernel, rhizoma atractylodis macrocephalae, Poria cocos, Chinese yam, rhizoma zingiberis, Agalloch eaglewood, psoralea corylifolia, radix cyathulae, Semen Cuscutae, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into the fritter of soya bean size, are uniformly mixed When sterilization treatment 1 is small under ultraviolet sterilizing lamp afterwards, it is subsequently placed in container and is soaked 60-100 minutes with normal-temperature water;
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow boiling heats 30 points Clock, dries in the air after being down to 50-70 DEG C to temperature, takes filtrate, and the dregs of a decoction in marmite are spare, and filtrate is poured into container;
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire 20 minutes, dry in the air after being down to 50-70 DEG C to temperature, filter to obtain secondary liquid;
4), the liquid obtained in step 2) and step 3) is merged, and is uniformly mixed, bottles or packs after drying in the air to room temperature, Obtain Traditional Chinese medicine composition liquid medicine.
The above method prepare be for traditional Chinese herbal decoction, the instructions of taking of this traditional Chinese herbal decoction:Take in three times within 1 day.Also can be 1 time Property decoct the dose of 2 days, filling and sealing after obtained liquid is sterilized, refrigeration, first micro- heating when taking.This Chinese traditional medicine composition Thing can also be prepared into powder capsule, and concrete scheme is as follows:
The preparation method of the Chinese medicine composition for the treatment of chronic cardiopulmonary disease as described above, it is characterised in that the preparation method bag Include following steps:
1), weigh by weight red ginseng, radix astragali, Schisandra chinensis, keel, oyster, jujube kernel, rhizoma atractylodis macrocephalae, Poria cocos, Chinese yam, rhizoma zingiberis, Agalloch eaglewood, psoralea corylifolia, radix cyathulae, Semen Cuscutae, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into the fritter of soya bean size, are uniformly mixed When sterilization treatment 1 is small under ultraviolet sterilizing lamp afterwards, powder is then ground to, after crossing 500-800 mesh sieves point, obtains herb powder;
2), the herb powder for obtaining step 1), which is fitted into capsule skin, is made Chinese medicinal capsule.
Further, the preparation method 1) granularity of herb powder that obtains in step is 600 mesh.
The Chinese medicine composition of the present invention has no toxic side effect, and therapeutic effect is good, treats both principal and secondary aspect of disease, uneasy to recur, to the chronic pulmonary heart Disease has good therapeutic effect.
The Chinese medicine composition can be prepared into the diversified forms such as Chinese medicinal tablet, particle, traditional Chinese medicine pill, be not limited to decoction and Capsule, suitable for a variety of therapeutic modalities, application method.
The pharmacology of all kinds of Chinese medicines is as follows in the present invention:
Red ginseng:Taste:It is sweet, bitter;Property:Temperature;Enter the heart, lung, the spleen channel;Function:Reinforce vital energy, veins takes off admittedly, nourishing qi to stop;It is main Control:Physically weak to be taken off, cold weak pulse of limb is Qi dysfunction in blood control, metrostaxis;Heart failure, cardiogenic shock.
Radix astragali:It is sweet in flavor;It is warm-natured;Enter spleen, lung channel;Function:Invigorating qi for strengthening superficies, torr sore myogenic, Li Shui;Cure mainly:Deficient qi and blood, from Sweat, rush down prolapse of the anus for a long time, the prolapse of uterus, ephritis edema, albuminuria, diabetes, chronic ulcer.
Schisandra chinensis:It is sour, sweet;It is warm-natured, return lung, the heart, kidney channel.Function:Astringe the lung, nourshing kidney, promotes the production of body fluid, and receives sweat, puckery essence.Cure mainly: The deficiency syndrome of the lung is breathed with cough, thirst, spontaneous perspiration, night sweat, and internal lesion caused by overexertion is thin thin, emission, protracted dysentery and diarrhea.
Keel:It is sweet in flavor, puckery, it is mild-natured, enter liver, the heart, kidney channel.Function:Tranquillizing the mind by relieving convulsion, arrest sweating controlling nocturnal emission with astringent drugs, stop blooding puckery intestines, and myogenic is held back Sore.Cure mainly:Frightened epilepsy is demented, and palpitation is forgetful, insomnia and dreamful sleep, spontaneous sweating, and stranguria with turbid discharge of passing out semen, hematemesis is had blood in stool, and under uterine bleeding band, rush down dysentery takes off Anus, ulcer do not close up long.
Oyster:Taste:It is salty;Property:It is cold;Enter liver and kidney channel;Function:It is calming the liver;It is transquilization with heavy material;Softening and resolving hard mass;Restrain astringent method; Cure mainly:Dizziness and tinnitus;Insomnia of palpitating with fear;Scrofula goiter and tumor;Abdominal mass lump in the abdomen;Spontaneous sweating;Seminal emission;Uterine bleeding;Under band.
Jujube kernel:Taste:It is sweet, sour;Property:It is flat;Function:Conscience is nourished, is calmed the nerves, arrest sweating;Cure mainly:Deficiency of YIN-blood, palpitation and severe palpitation, loses Sleep forgetful;Body void hidrosis.
Rhizoma atractylodis macrocephalae:It is bitter, sweet;It is warm-natured, returns spleen, stomach.Function:Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, tocolysis.Cure mainly: Spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema.Fetal irritability.
Poria cocos:It is sweet in flavor, light;It is mild-natured;The thoughts of returning home, lung, spleen, kidney channel.Function:Clearing damp and promoting diuresis, invigorating the spleen, calming heart.Cure mainly:Oedema is urinated It is few, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Chinese yam:Taste:It is sweet;Property:It is flat;Enter spleen, lung, kidney channel;Function:Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying;Cure mainly:Spleen Void, chronic diarrhea, the deficiency syndrome of the lung, kidney deficiency, with, frequent micturition.
Rhizoma zingiberis:Taste:It is pungent;Property:Heat;Enter spleen, stomach, the heart, lung channel;Function:Warming spleen and stomach for dispelling cold, Back to Yang Tongmai, eliminating dampness dissolving phlegm, warm lung Change drink.;Cure mainly:Coldness and pain in the epigastrium, vomiting, diarrhea, yang depletion faint inverse, cold drink breath with cough, numbness and ache of cold dampness.
Agalloch eaglewood:Taste:It is pungent, bitter;Property:Temperature;Enter stomach, spleen, kidney channel;Function:Promoting qi circulation and relieving pain, warming middle energizer to arrest vomiting, gas of receiving are relievingd asthma;It is main Control:Vexed pain that chest and abdomen are swollen, gastrofrigid vomiting hiccup, the asthma of the kidney deficiency circulation of vital energy in the wrong direction are anxious.
Psoralea corylifolia:Acrid flavour, hardship;It is warm-natured;Enter spleen, kidney channel;Function:It is warming spleen and stopping diarrha, tonifying kidney and strengthening yang, astringent sperm contracting urine;Cure mainly:Spleen The cold of insufficiency type is rushed down, impotence due to deficiency of the kidney, frequent micturition of passing out semen, waist and knee crymodynia.
Radix cyathulae:Taste:It is bitter;Property:It is flat;Enter kidney channel;Function:Wind-dispelling, dampness removing, promoting menstruation, promoting blood circulation;Cure mainly:Amenorrhea abdominal mass, afterbirth Under not, joint pain, sufficient impotence muscle contraction, cards such as hematuria blood drenches, injury from falling down.
Semen Cuscutae:It is acrid flavour, sweet;It is mild-natured;Enter liver,kidney,spleen warp;Function:Mend Yang and benefiting Yin, astringent sperm contracting urine, improving eyesight, antidiarrheal;It is main Control:Blood, movement of the foetus are intended to fall under lumbago due to the kidney deficiency, impotence and seminal emission, frequent urination, mesh dark unknown, splenasthenic diarrhea, threatened abortion.
Radix glycyrrhizae:It is sweet in flavor:It is mild-natured.The thoughts of returning home, spleen, lung, stomach.Function:Invigorate the spleen and benefit qi, moisten the lung and relieve the cough, clearing heat and detoxicating, alleviation stops Bitterly, pharmacological property is relaxed.Cure mainly:Weakness of the spleen and the stomach, shortness of breath and fatigue, palpitation and severe palpitation, cough phlegm is few, pathopyretic ulcer, medicine food poisoning, and gastral cavity abdomen is anxious Bitterly, four limbs contraction pain.
" organic conception " is had been accepted as at present, " diagnosis and treatment based on an overall analysis of the illness and the patient's condition ", " compound use ", " compound compatibility medication is such as used military forces " are the traditional Chinese medical science Most scientific most effective several big advantages, wherein " compound compatibility medication is such as used military forces " is the original theory of traditional Chinese medicine of very science.In The tight compatibility that each medicine is all linked with one another as arraying troops for battle in prescription is cured, is that it is better than the effective means of western medicine formula.The traditional Chinese medical science Prescription theory thinks that each prescription, not only needs to select the suitable appropriate compatibility of medicine according to etiology and pathogenesis, while should also accord with Close the prescription compatibility theory of the basic structure of prescription, i.e. " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make ", just It is that it establishes the scientific matching on the comprehensive judgement basis to the disease interpretation of the cause, onset and process of an illness.Middle medical square is whole by too many levels, Mutiple Targets The biological mechanism adjusted is closed, therapeutic effect more more longlasting than Western medicine, that more green natural has no toxic side effect can be obtained, and it is this Curative effect is built upon on the original theoretical accurate instruction of above-mentioned traditional Chinese medical science tradition, and the present invention just have followed this principle.
Monarch drug in a prescription treats primary symptom in the side of referring to, plays the medicine of primary treatment, can use as required simply or a few taste medicines.Minister Medicine is the medicine assisted main ingredient or strengthen main ingredient effect.Adjutant is the medicine for the toxicity assisted main ingredient treatment and disease or suppress main ingredient Thing.It is that each medicine of guiding goes directly diseased region or the effect of each medicine of reconciling to make medicine.
The present invention is to reinforce vital energy, and veins takes off admittedly, the red ginseng of nourishing qi to stop is monarch drug in a prescription;With invigorating qi for strengthening superficies, torr sore myogenic, profit The radix astragali of water, astringe the lung, and nourshing kidney, promotes the production of body fluid, and receives sweat, puckery smart Schisandra chinensis is ministerial drug;With tranquillizing the mind by relieving convulsion, arrest sweating controlling nocturnal emission with astringent drugs, stop blooding puckery intestines, It is the keel of myogenic sore, calming the liver;It is transquilization with heavy material;Softening and resolving hard mass;Restrain the oyster of astringent method, nourish conscience, calm the nerves, arrest sweating Jujube kernel, strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, the rhizoma atractylodis macrocephalae of tocolysis, clearing damp and promoting diuresis, invigorating the spleen, the Poria cocos of calming heart, tonifying spleen nourishing the stomach are raw Tianjin benefit lung, the puckery smart Chinese yam of kidney tonifying, warming spleen and stomach for dispelling cold, Back to Yang Tongmai, eliminating dampness dissolving phlegm, the rhizoma zingiberis of Wenfei of drink, promoting qi circulation and relieving pain, middle benefit gas Preventing or arresting vomiting, agalloch eaglewood that gas of receiving is relievingd asthma, warming spleen and stopping diarrha, tonifying kidney and strengthening yang, the psoralea corylifolia of astringent sperm contracting urine, wind-dispelling, dampness removing, promoting menstruation, promoting blood circulation Radix cyathulae, benefit Yang and benefiting Yin, astringent sperm contracting urine, improving eyesight, the Semen Cuscutae of antidiarrheal are adjutant;To invigorate the spleen and benefit qi, moisten the lung and relieve the cough, heat-clearing solution Poison, alleviates analgesic, and the radix glycyrrhizae for relaxing pharmacological property is to make medicine.Compatibility is reasonable, has no toxic side effect, and can fundamentally treat the chronic pulmonary heart Disease, quick, short treating period, will not cultivate the drug resistance of bacterium, cheap.
The Chinese medicine composition medicine source broad covered area of the present invention, compatibility is scientific and reasonable, brings out the best in each other, and plays righting altogether and sustains losses in business, is warm Lung resolving sputum, evacuation fever and chills, the work(of inducing meastruation to relieve menalgia, tonifying spleen and stomach, lesion depths of going directly, to the cause of disease of chronic cor pulmonale into Row is targetedly put in poison, and has reached the effect of clearing heat and detoxicating, antibacterial anti-inflammatory and resolving sputum and relieving asthma;At the same time, additionally it is possible to nurse one's health people comprehensively Internal portion function, has the function that tonifying Qi kidney-nourishing, mends fire supporing yang and antitoxic heart-soothing and sedative, enhances the immunity of human body, improve people The disease resistance of body;Treatment for chronic cardiopulmonary disease has evident in efficacy, quick, cure rate height, efficacy stability, the side of taking Just, the characteristics of having no toxic side effect.
Embodiment
The present invention is further described with reference to embodiment.
Embodiment one:
A kind of Chinese medicine composition for treating chronic cardiopulmonary disease, it is characterised in that the Chinese medicine by following parts by weight raw material group Into:30 parts of red ginseng, 15 parts of radix astragali, 20 parts of Schisandra chinensis, 30 parts of keel, 30 parts of oyster, 20 parts of jujube kernel, 20 parts of rhizoma atractylodis macrocephalae, Poria cocos 15 Part, 15 parts of Chinese yam, 15 parts of rhizoma zingiberis, 15 parts of agalloch eaglewood, 25 parts of psoralea corylifolia, 15 parts of radix cyathulae, 15 parts of Semen Cuscutae, 9 parts of radix glycyrrhizae.
The present embodiment also discloses a kind of preparation method of the Chinese medicine composition for the treatment of chronic cardiopulmonary disease as described above, It is characterized in that the preparation method includes the following steps:
1) 30 parts of red ginseng, 15 parts of radix astragali, 20 parts of Schisandra chinensis, 30 parts of keel, 30 parts of oyster, jujube kernel 20, are weighed by weight Part, 20 parts of rhizoma atractylodis macrocephalae, 15 parts of Poria cocos, 15 parts of Chinese yam, 15 parts of rhizoma zingiberis, 15 parts of agalloch eaglewood, 25 parts of psoralea corylifolia, 15 parts, Tu of radix cyathulae Sub 15 parts, 9 parts of radix glycyrrhizae, screening removal of impurities, larger raw material is cut into the fritter of soya bean size, after mixing in ultraviolet sterilizing lamp When lower sterilization treatment 1 is small, it is subsequently placed in container and is soaked 60 minutes with normal-temperature water;
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow boiling heats 30 points Clock, dries in the air after being down to 50 DEG C to temperature, takes filtrate, and the dregs of a decoction in marmite are spare, and filtrate is poured into container;
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire 20 minutes, dry in the air after being down to 50 DEG C to temperature, filter to obtain secondary liquid;
4), the liquid obtained in step 2) and step 3) is merged, and is uniformly mixed, bottles or packs after drying in the air to room temperature, Obtain Traditional Chinese medicine composition liquid medicine.
Embodiment two
A kind of Chinese medicine composition for treating chronic cardiopulmonary disease, it is characterised in that the Chinese medicine composition by following parts by weight original Material composition:20 parts of red ginseng, 10 parts of radix astragali, 15 parts of Schisandra chinensis, 20 parts of keel, 20 parts of oyster, 15 parts of jujube kernel, 15 parts of rhizoma atractylodis macrocephalae, Fu 10 parts of Siberian cocklebur, 10 parts of Chinese yam, 10 parts of rhizoma zingiberis, 10 parts of agalloch eaglewood, 15 parts of psoralea corylifolia, 10 parts of radix cyathulae, 10 parts of Semen Cuscutae, 6 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of chronic cardiopulmonary disease as described above at the same time, It is characterized in that the preparation method includes the following steps:
1) 20 parts of red ginseng, 10 parts of radix astragali, 15 parts of Schisandra chinensis, 20 parts of keel, 20 parts of oyster, jujube kernel 15, are weighed by weight Part, 15 parts of rhizoma atractylodis macrocephalae, 10 parts of Poria cocos, 10 parts of Chinese yam, 10 parts of rhizoma zingiberis, 10 parts of agalloch eaglewood, 15 parts of psoralea corylifolia, 10 parts, Tu of radix cyathulae Sub 10 parts, 6 parts of radix glycyrrhizae, screening removal of impurities, larger raw material is cut into the fritter of soya bean size, after mixing in ultraviolet sterilizing lamp When lower sterilization treatment 1 is small, powder is then ground to, after crossing 500 mesh sieves point, obtains herb powder;
2), the herb powder for obtaining step 1), which is fitted into capsule skin, is made Chinese medicinal capsule.
Embodiment three:
A kind of Chinese medicine composition for treating chronic cardiopulmonary disease, it is characterised in that the Chinese medicine composition by following parts by weight original Material composition:22 parts of red ginseng, 11 parts of radix astragali, 16 parts of Schisandra chinensis, 22 parts of keel, 22 parts of oyster, 16 parts of jujube kernel, 16 parts of rhizoma atractylodis macrocephalae, Fu 11 parts of Siberian cocklebur, 11 parts of Chinese yam, 11 parts of rhizoma zingiberis, 11 parts of agalloch eaglewood, 16 parts of psoralea corylifolia, 11 parts of radix cyathulae, 11 parts of Semen Cuscutae, 7 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of chronic cardiopulmonary disease as described above at the same time, It is characterized in that the preparation method includes the following steps:
1) 22 parts of red ginseng, 11 parts of radix astragali, 16 parts of Schisandra chinensis, 22 parts of keel, 22 parts of oyster, jujube kernel 16, are weighed by weight Part, 16 parts of rhizoma atractylodis macrocephalae, 11 parts of Poria cocos, 11 parts of Chinese yam, 11 parts of rhizoma zingiberis, 11 parts of agalloch eaglewood, 16 parts of psoralea corylifolia, 11 parts, Tu of radix cyathulae Sub 11 parts, 7 parts of radix glycyrrhizae, screening removal of impurities, larger raw material is cut into the fritter of soya bean size, after mixing in ultraviolet sterilizing lamp When lower sterilization treatment 1 is small, it is subsequently placed in container and is soaked 80 minutes with normal-temperature water;
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow boiling heats 30 points Clock, dries in the air after being down to 60 DEG C to temperature, takes filtrate, and the dregs of a decoction in marmite are spare, and filtrate is poured into container;
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire 20 minutes, dry in the air after being down to 60 DEG C to temperature, filter to obtain secondary liquid;
4), the liquid obtained in step 2) and step 3) is merged, and is uniformly mixed, bottles or packs after drying in the air to room temperature, Obtain Traditional Chinese medicine composition liquid medicine.
Example IV:
A kind of Chinese medicine composition for treating chronic cardiopulmonary disease, it is characterised in that the Chinese medicine composition by following parts by weight original Material composition:25 parts of red ginseng, 13 parts of radix astragali, 27 parts of Schisandra chinensis, 25 parts of keel, 25 parts of oyster, 17 parts of jujube kernel, 17 parts of rhizoma atractylodis macrocephalae, Fu 13 parts of Siberian cocklebur, 13 parts of Chinese yam, 13 parts of rhizoma zingiberis, 13 parts of agalloch eaglewood, 20 parts of psoralea corylifolia, 13 parts of radix cyathulae, 13 parts of Semen Cuscutae, 8 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of chronic cardiopulmonary disease as described above at the same time, It is characterized in that the preparation method includes the following steps:
1) 25 parts of red ginseng, 13 parts of radix astragali, 27 parts of Schisandra chinensis, 25 parts of keel, 25 parts of oyster, jujube kernel 17, are weighed by weight Part, 17 parts of rhizoma atractylodis macrocephalae, 13 parts of Poria cocos, 13 parts of Chinese yam, 13 parts of rhizoma zingiberis, 13 parts of agalloch eaglewood, 20 parts of psoralea corylifolia, 13 parts, Tu of radix cyathulae Sub 13 parts, 8 parts of radix glycyrrhizae, screening removal of impurities, larger raw material is cut into the fritter of soya bean size, after mixing in ultraviolet sterilizing lamp When lower sterilization treatment 1 is small, powder is then ground to, after crossing 600 mesh sieves point, obtains herb powder;
2), the herb powder for obtaining step 1), which is fitted into capsule skin, is made Chinese medicinal capsule.
Embodiment five:
A kind of Chinese medicine composition for treating chronic cardiopulmonary disease, it is characterised in that the Chinese medicine composition by following parts by weight original Material composition:28 parts of red ginseng, 14 parts of radix astragali, 18 parts of Schisandra chinensis, 28 parts of keel, 28 parts of oyster, 18 parts of jujube kernel, 18 parts of rhizoma atractylodis macrocephalae, Fu 14 parts of Siberian cocklebur, 14 parts of Chinese yam, 14 parts of rhizoma zingiberis, 14 parts of agalloch eaglewood, 24 parts of psoralea corylifolia, 14 parts of radix cyathulae, 14 parts of Semen Cuscutae, 8 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of chronic cardiopulmonary disease as described above at the same time, It is characterized in that the preparation method includes the following steps:
1) 28 parts of red ginseng, 14 parts of radix astragali, 18 parts of Schisandra chinensis, 28 parts of keel, 28 parts of oyster, jujube kernel 18, are weighed by weight Part, 18 parts of rhizoma atractylodis macrocephalae, 14 parts of Poria cocos, 14 parts of Chinese yam, 14 parts of rhizoma zingiberis, 14 parts of agalloch eaglewood, 24 parts of psoralea corylifolia, 14 parts, Tu of radix cyathulae Sub 14 parts, 8 parts of radix glycyrrhizae, screening removal of impurities, larger raw material is cut into the fritter of soya bean size, after mixing in ultraviolet sterilizing lamp When lower sterilization treatment 1 is small, it is subsequently placed in container and is soaked 80 minutes with normal-temperature water;
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow boiling heats 30 points Clock, dries in the air after being down to 70 DEG C to temperature, takes filtrate, and the dregs of a decoction in marmite are spare, and filtrate is poured into container;
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire 20 minutes, dry in the air after being down to 70 DEG C to temperature, filter to obtain secondary liquid;
4), the liquid obtained in step 2) and step 3) is merged, and is uniformly mixed, bottles or packs after drying in the air to room temperature, Obtain Traditional Chinese medicine composition liquid medicine.
The present invention has carried out clinical efficacy tracking with the data given by embodiment 1 at the same time, and curative effect is summarized as follows:
1. selecting Patients with Chronic Cor Pulmonale 50, age 35-65 Sui, average age 52 years old, is randomly divided into two groups by patient, controls There was no significant difference for the data such as treatment group 25, control group 25, two groups of ages, is comparable.Its common classical symptom is Cough, cough up phlegm, having difficulty in breathing, palpitaition shortness of breath, cyanosis of the lips and nails, abdominal distension oedema, pulmonary rale, tongue nature, tongue fur, pulse condition are abnormal.
2. treatment method, treatment group takes orally Chinese medicine composition made from optimization formula embodiment 1 of the present invention, per bu sooner or later Take twice, the course for the treatment of 18 days.Control group takes orally general treatment Common drugs, is according to dosage taken daily with number, the course for the treatment of 18 days.
3. diagnostic criteria
All cases meet what State Administration of Traditional Chinese Medicine issued《Chinese medical disease diagnostic criteria》In diagnostic criteria.Ginseng According to《New Chinese medicine guideline of clinical investigations》Relevant criterion is worked out.
It is effective:Chronic cardiopulmonary disease shape substantially mitigates, and checks that indices tend to be normal, and cardio-pulmonary function, which improves, reaches two level;
Effectively:Property pulmonary heart disease shape slightly mitigate, check indices improved, cardio-pulmonary function improve reaches level-one;
It is invalid:Symptom after taking medicine sign and inspection without improvement or improve unobvious.
4. treatment results, coughed, panted before and after treatment according to patient, the clinical symptoms change situation analysis such as chest is suppressed, edema: Effective the 75% for the treatment of group, effective 10%, invalid 15%, total effective rate 85%;Effective the 35% of control group, effective 22%, nothing Effect 43%, total effective rate 57%.
The result shows that Chinese medicine preparation of the invention, can effectively adjust organism quality, there is treatment for treating chronic cardiopulmonary disease The advantages that definite, cheap, without side-effects, cure rate is high uneasy to recur is imitated, is worth clinical application.
Moreover, in terms of clinical observation result, treatment group's symptom obvious effective rate, total effective rate are obviously higher than control group, it is seen that The acute phase of cor pulmonale clinical symptoms such as this Chinese medicine preparation is to coughing, panting, chest is suppressed, edema improve obvious.At the same time in safety Property evaluation in, the inspection such as the front and rear blood routine for the treatment of group patient medication, routine urinalysis, electrocardiogram does not find obvious exception.Thus say Bright particularly treated using Chinese medicine preparation treatment acute phase of cor pulmonale of the present invention belongs to syndrome of qi deficiency of lung and kidney chronic cardiopulmonary disease urgency Property the phase it is curative for effect, securely and reliably, can as treatment syndrome of qi deficiency of lung and kidney acute phase of cor pulmonale effective ways, in clinic It is worth of widely use.
The Chinese medicine of the present invention has carried out toxicity test, and test effect is as follows:
Select 20~22 grams of weight, the healthy mice of 13 week old (homogeneous test body heavy phase difference is no more than 2 grams).Rat 22 weeks Age;86~96 grams of weight, homogeneous test body heavy phase difference are no more than 10g.During experiment, animal is randomly divided into 4~5 groups by volume, Every group of at least 10 animals, to reaction of animals situation is observed after tested material at once, once, continuous observation 6 months, sees for observation daily Examine toxic reaction, should, pays attention to the record appearance of animal, behavioral activity, the state of mind, appetite (feed consumption), stool and urine and Its color, hair, the colour of skin, breathing, nose, eye, oral cavity secretion without exception, changes of weight etc., compared with control group, administration group is small White mouse physical condition is normal, and has no that small white mouse is sick or dead.Prompt the medicine security good, have no toxic side effect.
The treatment case of the Chinese medicine of the present invention is as follows:
Case one, Zhao, female, 64 years old.Patient has chronic cough, expectoration medical history more than 10 years, on flu often cause cough, Expectoration, breaking-out of panting, cough up white foam sample phlegm, when and cough up yellow phlegm, sputum is in mucopurulent sputum, is not easy expectoration, and flu is all every time Simple is treated with cold symptoms, in winter last year, is occasionally caught a cold, and is repeatedly treated not plus is improved with cold symptoms, disease Shape aggravates on the contrary, the symptom such as palpitaition, shortness of breath, weak, anorexia, drowsiness, pain uncomfortable in chest occurs, is carried out to the People's Hospital at county level Checking, outpatient service is in hospital with " chronic obstructive emphysema, pulmonary heart disease " income, is hospitalized for treatment after a week, and above-mentioned symptom does not improve, When coming here and being treated, purple lips dark purple, edema of lower extremity, expiratory dyspnea, increased heart rate, cardiac arrhythmia, took the present invention after 3 days, Sensory symptoms has mitigated, and takes the reaction without palpitaition, shortness of breath after a week of the invention, appetite is normal, occurs dry cough once in a while.Afterwards The symptom such as adhere to no longer occurring after taking one month coughing.Other every Index for examination tend to be normal, and follow-up is without multiple after 1 year Hair.
Case two, Zhao, man, has checked pulmonary emphysema, in order to for children's schooling, during which take always before 57 years old, 20 years Western medicine carries out diagnosis and treatment, in recent years, with the increase at age, gradually in addition to cough and expectoration, gradually feel weak, food occur Be intended to decline, be drowsiness, asthma, uncomfortable in chest, chest pain, last year feels unsmooth breath, nervous, the difficult symptom such as sleep, carried out to county people's hospital Check, be diagnosed as lang-QI disease, symptom has improved after hospital carries out the treatment of one week, and medication always of going home is treated. But the state of an illness always hangs in the balance, treated to here, edema disease occur in chest pain, shortness of breath, lower part of the body as pin is pricked when coming Shape, took the present invention after 5 days, and lower part of the body edema disappears, chest without pain, once in a while on foot when the symptom of shortness of breath occurs, take After 15 days, the symptom without shortness of breath occurs the present invention, removes examination in hospital, indices tend to be normal.
Case three, Zhang, man, 55 years old, Patients with Chronic Cor Pulmonale, chronic cough, expectoration and different degrees of expiratory dyspnea, Particularly symptom becomes apparent after activity or in cold season, removes examination in hospital, there is pulmonary hypertension, the increase of the right heart and the right heart Insufficiency symptom.Take the Chinese medicine composition of the present invention 18 days, cough and expectoration symptom is clearly better, and breathing is no longer difficult, with After continue to take 35 days, symptom substantially mitigates, and tends to be normal, removes examination in hospital, and indices tend to be normal, then often take This medicine, expectoration cough, expiratory dyspnea symptom no longer recur.
Case four, position, female, starts to breathe regular relatively difficult before 41 years old, 5 months.Severity uncomfortable in chest, there is kind of an asthma The but sensation of gas.X pieces have been clapped in local hospital when probably before nearly 1 month, have beaten drop, therapeutic effect unobvious, take The Chinese medicine composition of the present invention 8 days, hence it is evident that improve, continue thereafter with and take 35 days, symptom substantially mitigates, and tends to be normal, goes to hospital Check, indices tend to be normal, then often take this medicine, uncomfortable in chest, and asthma shape no longer recurs..
Case five, Lee, man, 65 years old.Cough and asthma, cough symptom, is set to pulmonary heart disease through local hospital x film makings.Add Strong later Slightly improve after treatment, introduced through friend and eat folk prescription " new asthma is peaceful to be dissipated " always, effect is general, has continuously taken 6-7, has adhered to always Take.There is sagging sensation in walking Duan Lian Time Hui Chu Now hearts before one month, Xiong Men Time are slightly with hand microtorr chest [close under heart Portion] there is positive effect, start to take the Chinese medicine composition decoction of the present invention after 15 days, then the sagging sense of acardia, without sense uncomfortable in chest, after Continuous take 35 days consolidates curative effect, then often takes the Chinese medicine composition of the present invention, pulmonary heart disease symptom is without obvious recurrence.
It is understood that above with respect to the specific descriptions of the present invention, it is merely to illustrate the present invention and is not limited to this The described technical solution of inventive embodiments, it will be understood by those of ordinary skill in the art that, still the present invention can be carried out Modification or equivalent substitution, to reach identical technique effect;As long as meet use needs, all protection scope of the present invention it It is interior.

Claims (7)

  1. A kind of 1. Chinese medicine composition for treating chronic cardiopulmonary disease, it is characterised in that the Chinese medicine composition by following parts by weight raw material Composition:20-30 parts of red ginseng, 10-15 parts of radix astragali, 15-20 parts of Schisandra chinensis, 20-30 parts of keel, 20-30 parts of oyster, jujube kernel 15-20 Part, 15-20 parts of rhizoma atractylodis macrocephalae, 10-15 parts of Poria cocos, 10-15 parts of Chinese yam, 10-15 parts of rhizoma zingiberis, 10-15 parts of agalloch eaglewood, psoralea corylifolia 15-25 Part, 10-15 parts of radix cyathulae, 10-15 parts of Semen Cuscutae, 6-9 parts of radix glycyrrhizae.
  2. A kind of 2. Chinese medicine composition for treating chronic cardiopulmonary disease according to claim 1, it is characterised in that the Chinese traditional medicine composition Thing is made of the raw material of following parts by weight:22 parts of red ginseng, 11 parts of radix astragali, 16 parts of Schisandra chinensis, 22 parts of keel, 22 parts of oyster, jujube kernel 16 parts, 16 parts of rhizoma atractylodis macrocephalae, 11 parts of Poria cocos, 11 parts of Chinese yam, 11 parts of rhizoma zingiberis, 11 parts of agalloch eaglewood, 16 parts of psoralea corylifolia, 11 parts of radix cyathulae, Tu Silk 11 parts, 7 parts of radix glycyrrhizae.
  3. A kind of 3. Chinese medicine composition for treating chronic cardiopulmonary disease according to claim 1, it is characterised in that the Chinese traditional medicine composition Thing is made of the raw material of following parts by weight:25 parts of red ginseng, 13 parts of radix astragali, 27 parts of Schisandra chinensis, 25 parts of keel, 25 parts of oyster, jujube kernel 17 parts, 17 parts of rhizoma atractylodis macrocephalae, 13 parts of Poria cocos, 13 parts of Chinese yam, 13 parts of rhizoma zingiberis, 13 parts of agalloch eaglewood, 20 parts of psoralea corylifolia, 13 parts of radix cyathulae, Tu Silk 13 parts, 8 parts of radix glycyrrhizae.
  4. A kind of 4. Chinese medicine composition for treating chronic cardiopulmonary disease according to claim 1, it is characterised in that the Chinese traditional medicine composition Thing is made of the raw material of following parts by weight:28 parts of red ginseng, 14 parts of radix astragali, 18 parts of Schisandra chinensis, 28 parts of keel, 28 parts of oyster, jujube kernel 18 parts, 18 parts of rhizoma atractylodis macrocephalae, 14 parts of Poria cocos, 14 parts of Chinese yam, 14 parts of rhizoma zingiberis, 14 parts of agalloch eaglewood, 24 parts of psoralea corylifolia, 14 parts of radix cyathulae, Tu Silk 14 parts, 8 parts of radix glycyrrhizae.
  5. 5. a kind of preparation method of the Chinese medicine composition for the treatment of chronic cardiopulmonary disease as any one of claim 1-4, its It is characterized in that the preparation method includes the following steps:
    1) red ginseng, radix astragali, Schisandra chinensis, keel, oyster, jujube kernel, rhizoma atractylodis macrocephalae, Poria cocos, Chinese yam, rhizoma zingiberis, heavy, is weighed by weight Perfume, psoralea corylifolia, radix cyathulae, Semen Cuscutae, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into the fritter of soya bean size, after mixing When sterilization treatment 1 is small under ultraviolet sterilizing lamp, it is subsequently placed in container and is soaked 60-100 minutes with normal-temperature water;
    2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow boiling heats 30 minutes, dries in the air After being down to 50-70 DEG C to temperature, filtrate is taken, the dregs of a decoction in marmite are spare, and filtrate is poured into container;
    3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire 20 points Clock, dries in the air after being down to 50-70 DEG C to temperature, filters to obtain secondary liquid;
    4), the liquid obtained in step 2) and step 3) is merged, and is uniformly mixed, bottles or packs after drying in the air to room temperature, in obtaining Drug composition liquid.
  6. 6. a kind of preparation method of the Chinese medicine composition for the treatment of chronic cardiopulmonary disease as any one of claim 1-4, its It is characterized in that the preparation method includes the following steps:
    1) red ginseng, radix astragali, Schisandra chinensis, keel, oyster, jujube kernel, rhizoma atractylodis macrocephalae, Poria cocos, Chinese yam, rhizoma zingiberis, heavy, is weighed by weight Perfume, psoralea corylifolia, radix cyathulae, Semen Cuscutae, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into the fritter of soya bean size, after mixing When sterilization treatment 1 is small under ultraviolet sterilizing lamp, powder is then ground to, after crossing 500-800 mesh sieves point, obtains herb powder;
    2), the herb powder for obtaining step 1), which is fitted into capsule skin, is made Chinese medicinal capsule.
  7. A kind of 7. preparation method of Chinese medicine composition for treating chronic cardiopulmonary disease according to claim 6, it is characterised in that The preparation method 1) granularity of herb powder that obtains in step is 600 mesh.
CN201711302574.4A 2017-12-11 2017-12-11 A kind of Chinese medicine composition for treating chronic cardiopulmonary disease and preparation method thereof Pending CN107898988A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
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CN1310003A (en) * 2001-02-19 2001-08-29 孟庆云 Combined Chinese and Western medicine for treating pulmonary emphysema

Patent Citations (1)

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CN1310003A (en) * 2001-02-19 2001-08-29 孟庆云 Combined Chinese and Western medicine for treating pulmonary emphysema

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