CN102793826B - Traditional Chinese medicine for treating hypertension early-stage kidney damage and preparation method thereof - Google Patents
Traditional Chinese medicine for treating hypertension early-stage kidney damage and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating hypertension early-stage kidney damage and a preparation method thereof. The traditional Chinese medicine for treating hypertension early-stage kidney damage disclosed by the invention mainly comprises radix rehmanniae preparata, fructus corni, yam, cortex eucommiae, radix salviae miltiorrhizae and tortoise shell, and is preparedinto various common preparations by the traditional technology of traditional Chinese medicine. The traditional Chinese medicine for treating hypertension early-stage kidney damage disclosed by the invention can effectively relieve the kidney fibrosis progress of the patient suffering hypertension early-stage kidney damage, reduces the kidney burden of the patient, and effectively controls the disease progression; in combination with the oral hypotensor benazepril, a synergistic effect is realized for the blood pressure reducing effect; and compared with the oral hypotensor benazepril only, the traditional Chinese medicine disclosed by the invention takes effect quickly in reducing blood pressure, and the final blood pressure reducing effect is better. Compared with the prior art, the invention has outstanding substantial characteristics and obvious progress.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine for the treatment of the early stage renal damage of hypertension and preparation method thereof.
Background technology
China adult hypertension prevalence is 18.8%, and hypertensive patient about 1.6 hundred million is arranged at present.Because kidney is one of main target organ of hypertension infringement, the patient's number that has data to show that the kidney damage that causes owing to hypertension enters chronic renal insufficiency is year by year and increases, so how to prevent and treat the hypertension renal damage, early stage renal damage particularly, the development that delays the state of an illness has very important clinical meaning.
It is important to think that at present somatomedin has play a part in hypertensive renal damage, transforming growth factor-beta 1 (transforming growth factor-beta 1 wherein, TGF-β 1) Connective Tissue Growth Factor (connective tissue growth factor, CTGF), fibronectin (fibronectin, FN) in the generation of hypertensive renal disease renal fibrosis, play a crucial role in the development, its mechanism may cause blood vessel structure-dysfunction before the glomerule for: hypertension, make arterial hypertension directly act on glomerular capillary and cause glomerule inner high voltage power, cause glomerule inner high voltage power and HT, and influence the active substance of glomerular hemodynamics: as Angiotensin II (AngII), endothelin-1 (ET-1), the catecholamine material, NO, PGS etc., renal hemodynamics is changed, show as the rising of renal vascular resistance, thereby cause the minimizing of renal blood flow, cause renal ischaemia.Thereby cause renal fibrosis.
At present, doctor trained in Western medicine by the difference of goal, efferent glomerular arteriole degrees of expansion, thereby reaches situations such as reducing glomerule HT, high filtration mainly based on blood pressure lowerings such as ACEI, ARB treatment, alleviates the glomerule burden, reaches the effect that delays renal fibrosis.But studies show that at present, though with controlling of blood pressure in certain amplitude, the process of renal fibrosis is not obviously changed.
Motherland's medical science there is no the name of disease corresponding with hypertensive renal damage, and summary successive dynasties document surely belongs to categories such as " dizzy ", " lumbago ".Pathogenesis gets to the bottom of sb.'s illness, the early stage renal damage person of blood pressure diseases mostly is the old people of prolonged illness, system suffers from a deficiency of the kidney can not astringency inducing, the liver failing to maintain the normal flow of QI, the stasis of blood hinders in the kidney network in addition, causes kidney separating clear and excreting turbid malfunction, incontinence of urine, cereal nutrient is dirty, can show as the sign that urine α 1-microglobulin spills the early stage renal damages of hypertension such as increase.Its pathogenesis basis hepatic and renal YIN deficiency is this, and sick position is mainly at Liver and kidney.
The traditional Chinese medical science is less to the research of the early stage renal damage of hypertension at present, most based on suppressing the hyperactive liver and subsiding YANG, be " 200910055794.0 " as number of patent application, name is called the technology of putting down in writing in the Chinese invention patent application documents of " a kind of compound Chinese medicinal preparation for the treatment of the early high blood pressure renal damage ", its composition of raw materials has used Radix Rehmanniae Preparata, the Cortex Eucommiae, Herba Taxilli, Radix Cyathulae, Herba Apocyni veneti, Radix Puerariae, Ramulus Uncariae Cum Uncis, and treatment mechanism is based on " kidney tonifying suppressing the hyperactive liver ".
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine for the treatment of the early stage renal damage of hypertension and preparation method thereof, the Chinese medicine of the early stage renal damage for the treatment of hypertension provided by the present invention can effectively be alleviated the early stage renal damage patient of hypertension renal fibrosis process, alleviate patient's kidney burden, effectively control course of disease progress.
The Chinese medicine of the early stage renal damage for the treatment of hypertension of the present invention is to be formed by the feedstock production that comprises following weight portion:
Radix Rehmanniae Preparata 5～30 Fructus Corni 5～30 Rhizoma Dioscoreaes 8～40
The Cortex Eucommiae 5～30 Radix Salviae Miltiorrhizaes 8～30 Carapax Et Plastrum Testudiniss 8～40.
The Chinese medicine of the early stage renal damage for the treatment of hypertension of the present invention, its preferred version is to be formed by the feedstock production that comprises following weight portion:
Radix Rehmanniae Preparata 10～20 Fructus Corni 10～20 Rhizoma Dioscoreaes 15～25
The Cortex Eucommiae 10～20 Radix Salviae Miltiorrhizaes 15～25 Carapax Et Plastrum Testudiniss 15～25.
The Chinese medicine of the early stage renal damage for the treatment of hypertension of the present invention, its further preferred version is to be formed by the feedstock production that comprises following weight portion:
Radix Rehmanniae Preparata 12 Fructus Corni 12 Rhizoma Dioscoreaes 15
The Cortex Eucommiae 10 Radix Salviae Miltiorrhizaes 15 Carapax Et Plastrum Testudiniss 15.
The Chinese medicine of the early stage renal damage for the treatment of hypertension of the present invention, its active component is prepared from by the following method:
Get whole 6 flavor medical materials, extracting in water twice adds the water that is equivalent to 8～12 times of medical material gross weights for the first time, extracts 1～3 hour, adds the water that is equivalent to 8～12 times of medical material gross weights for the second time, extracts 1～2 hour; Merge extractive liquid,, relative density is 1.20～1.30 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 50%～65%, stir even, left standstill 12～24 hours, filter, relative density was 1.20～1.30 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
The Chinese medicine of the early stage renal damage for the treatment of hypertension of the present invention, its active component is to be prepared from by following method for optimizing:
Get whole 6 flavor medical materials, extracting in water twice adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds the water that is equivalent to 8～10 times of medical material gross weights for the second time, extracts 1.5 hours; Merge extractive liquid,, relative density is 1.25 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 55%～60%, stir and spare, left standstill 12～24 hours, filter, relative density was 1.25 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
The Chinese medicine of the early stage renal damage for the treatment of hypertension of the present invention can cooperate with pharmaceutically acceptable carrier, makes various common dosage forms.
The Chinese medicine details is as follows among the present invention:
Radix Rehmanniae Preparata
Radix Rehmanniae Preparata, the Chinese medicine name has another name called Radix Rehmanniae Preparata.Be scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa(Gdertn) Iibosch.ex Fisch. et Mey.) tuber concoct through processing and form.Usually be that adjuvant shines through steaming repeatedly with wine, Fructus Amomi, Pericarpium Citri Reticulatae, glossy to inside and outside darkish complexion, the quality softness is sticky.Section usefulness, or parch to black is used.After concocting, the property of medicine is by the commentaries on classics tepor that is slightly cold, the tonification enhancing.Sweet in the mouth, slightly warm in nature.Return liver, kidney channel.The function YIN nourishing of enriching blood, beneficial essence is filled out marrow.Be used for blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, and is dizzy, tinnitus, early whitening of beard and hair.
Fructus Corni
This product is the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb. Et Zucc..The picking fruit when time of the year when autumn changes into winter, peel reddened, with slow fire baking or put slightly scald in the boiling water after, in time except removal core, drying.Sour in the mouth, puckery, slightly warm in nature.Return liver, kidney channel.The function liver and kidney tonifying, arresting collape syndrome by astringents.Be used for dizzy ear toot, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, the profuse sweating collapse, interior-heat is quenched one's thirst.
Rhizoma Dioscoreae
These product are the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..Winter, stem and leaf was excavated after withering, and cut the root head, cleaned, and removed crust and fibrous root, after smoking with sulfur, and drying; Also have and select loose straight dry Rhizoma Dioscoreae, put in the clear water, be dipped into the no dried heart, vexed, after smoking with sulfur, trim two ends, be twisted into cylindricly with plank, dry polishing.Sweet in the mouth, property is flat.Return spleen, lung, kidney channel.Function spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Be used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.
The Cortex Eucommiae
This product is the dry bark of the Eucommiaceae plant Cortex Eucommiae (Eucommia ulmoides Oliver), and strip 4～June, scrapes off rough bark, and " diaphoresis " to the endothelium of banking up is puce, dries.Sweet in the mouth, warm in nature.Return liver, kidney channel.The function invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Be used for deficiency of the liver and kindey, soreness of waist and knee joint, muscles and bones is unable, has a dizzy spell blood leaking in gestation, frequent fetal movement.
Radix Salviae Miltiorrhizae
This product is dry root and the rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Spring, Qiu Erji excavate, and remove silt, drying.Bitter in the mouth, cold nature.GUIXIN, Liver Channel.The function blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, the relieving restlessness that clears away heart-fire, removing heat from blood eliminating carbuncle.Be used for obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, the abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, the dysmenorrhea amenorrhea, skin infection swells and ache.
Carapax Et Plastrum Testudinis
This product is carapace and the sternite of Testudinidae animal Testudinis Chinemys reevesii (Gray).All can catch the whole year, with autumn, two seasons of winter be many, kill after the seizure, or scald deadly with boiling water, strip carapace and sternite, remove residual meat, dry.Salty in the mouth, sweet, cold nature.Return liver, kidney, heart channel.The function nourishing YIN for suppressing the hyperactive YANG, the kidney tonifying bone strengthening, Gu the reinforcing the heart of nourishing blood is through only collapsing.Be used for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat is had a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and the muscles and bones flaccidity is soft, and it is forgetful to have a guilty conscience, and metrorrhagia is through many.
Motherland's medical science there is no the name of disease corresponding with hypertensive renal damage, and summary successive dynasties document surely belongs to categories such as " dizzy ", " lumbago ".Pathogenesis gets to the bottom of sb.'s illness, the early stage renal damage person of blood pressure diseases mostly is the old people of prolonged illness, system suffers from a deficiency of the kidney can not astringency inducing, the liver failing to maintain the normal flow of QI, the stasis of blood hinders in the kidney network in addition, causes kidney separating clear and excreting turbid malfunction, incontinence of urine, cereal nutrient is dirty, can show as the sign that urine α 1-microglobulin spills the early stage renal damages of hypertension such as increase.Its pathogenesis basis hepatic and renal YIN deficiency is this, and sick position is mainly at Liver and kidney.
The present invention is directed to the pathogenesis key of the early stage renal damage of hypertension, is key point with " nourishing the liver and kidney ", different with the mechanism of documents, and the treatment of the early stage renal damage of hypertension has been obtained effect preferably.
Among raw material of the present invention is formed: the moon of Radix Rehmanniae Preparata, Fructus Corni nourishing the liver and kidney, this two rich, through saying " rich be the yin aspect of yin ", in order to grow few the moon, the kidney invigorating water; Rhizoma Dioscoreae property is flat, mends and not rapid the dense kidney tonifying of liquid; Three medicines are monarch drug altogether, the effect of playing nourishing the liver and kidney altogether;
The sweet temperature of the Cortex Eucommiae is gone into Liver and kidney two warps, and temperature and mending, the liver and the kidney tonifying, residence are at treating YIN within YANG, in case the fraud of " solitary YIN is not given birth to, and solely sun is long ", as ministerial drug;
The Radix Salviae Miltiorrhizae bitter in the mouth is slightly cold, the usefulness that eliminating blood stasis and smoothing collaterals, suppressing the hyperactive liver are calmed the nerves." book on Chinese herbal medicine converges and says " said it and is apt to control blood system, removes the tissue regeneration promoting that stagnates, and regulating menstruation is along arteries and veins, and modern pharmacological research shows that Radix Salviae Miltiorrhizae has blood pressure lowering, reduces blood viscosity, anticoagulant, protection inner skin cell function, and other has study of anti-atherogenic effect, as adjuvant drug;
The Carapax Et Plastrum Testudinis sweet-salty, cold in nature, i.e. nourishing kidney is YANG hyperactivity suppressing again, with the containment rising liver-yang and for making medicine;
All medicines share liver and kidney tonifying, promoting tissue regeneration by removing blood stasis, and giving consideration to both the incidental and fundamental, adjust the dual power of negative and positive principles meets the Therapeutic Principle that the traditional Chinese medical science distinguishes that disease executing controlled.
Clinical test results as embodiment 6 shows, the Chinese medicine of the early stage renal damage for the treatment of hypertension of the present invention can effectively be alleviated the early stage renal damage patient of hypertension renal fibrosis process, has better therapeutic effect for the early stage renal damage of hypertension; When cooperating the enalapril meleate benazepril to use, have synergism for antihypertensive effect, with respect to independent use enalapril meleate benazepril, make that the blood pressure lowering onset is faster, final antihypertensive effect is better.The present invention has outstanding substantive distinguishing features and obvious improvement in terms of existing technologies.
The specific embodiment
Embodiment 1
Radix Rehmanniae Preparata 500g Fructus Corni 500g Rhizoma Dioscoreae 800g
Cortex Eucommiae 500g Radix Salviae Miltiorrhizae 800g Carapax Et Plastrum Testudinis 800g
Get whole 6 flavor medical materials, extracting in water twice adds 31200g water for the first time, extracts 1 hour, adds 31200g water for the second time, extracts 1 hour; Merge extractive liquid,, relative density is 1.20 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 50%, stir and spare, left standstill 12 hours, filter, relative density was 1.20 extractum when filtrate was concentrated into 80 ℃, namely got active component of the present invention.
Embodiment 2
Radix Rehmanniae Preparata 3000g Fructus Corni 3000g Rhizoma Dioscoreae 4000g
Cortex Eucommiae 3000g Radix Salviae Miltiorrhizae 3000g Carapax Et Plastrum Testudinis 4000g
Get whole 6 flavor medical materials, extracting in water twice adds 240000g water for the first time, extracts 1～3 hour, adds 240000g water for the second time, extracts 2 hours; Merge extractive liquid,, relative density is 1.30 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 65%, stir and spare, left standstill 24 hours, filter, relative density was 1.30 extractum when filtrate was concentrated into 80 ℃, namely got active component of the present invention;
Active component is mixed with an amount of sucrose, make granule, drying namely gets granule of the present invention.
Embodiment 3
Radix Rehmanniae Preparata 2500g Fructus Corni 2500g Rhizoma Dioscoreae 2000g
Cortex Eucommiae 2500g Radix Salviae Miltiorrhizae 2500g Carapax Et Plastrum Testudinis 2000g
Get whole 6 flavor medical materials, extracting in water twice adds 140000g water for the first time, extracts 2 hours, adds 110000g water for the second time, extracts 1.5 hours; Merge extractive liquid,, relative density is 1.25 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 56%, stir and spare, left standstill 24 hours, filter, relative density was 1.25 extractum when filtrate was concentrated into 80 ℃, namely got active component of the present invention;
Active component is mixed with an amount of sucrose and antiseptic, add water to 3000g, namely get oral liquid of the present invention.
Embodiment 4
Radix Rehmanniae Preparata 1500g Fructus Corni 1500g Rhizoma Dioscoreae 1500g
Cortex Eucommiae 1500g Radix Salviae Miltiorrhizae 1500g Carapax Et Plastrum Testudinis 1500g
Get whole 6 flavor medical materials, extracting in water twice adds 72000g water for the first time, extracts 2 hours, adds 90000g water for the second time, extracts 2 hours; Merge extractive liquid,, relative density is 1.27 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 55%, stir and spare, left standstill 18 hours, filter, relative density was 1.24 extractum when filtrate was concentrated into 80 ℃, namely got active component of the present invention;
Active component is mixed with appropriate amount of starch and dextrin, granulate, drying, tabletting namely gets tablet of the present invention.
Embodiment 5
Radix Rehmanniae Preparata 1500g Fructus Corni 1500g Rhizoma Dioscoreae 2000g
Cortex Eucommiae 1500g Radix Salviae Miltiorrhizae 1500g Carapax Et Plastrum Testudinis 2000g
Get whole 6 flavor medical materials, extracting in water twice adds 100000 water for the first time, extracts 1.5 hours, adds 110000 water for the second time, extracts 2 hours; Merge extractive liquid,, relative density is 1.22 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 58%, stir and spare, left standstill 16 hours, filter, relative density was 1.26 extractum when filtrate was concentrated into 80 ℃, namely got described active component;
Active component is put 70 ℃ of dryings in the vacuum drying oven, pulverized 100 mesh sieves, add appropriate amount of starch, silicon dioxide, magnesium stearate, make granule, drying incapsulates, and namely gets capsule of the present invention.
Embodiment 6
The clinical trial situation of Chinese medicine of the present invention:
Case is selected: get hyperpietic's 120 examples, all cases are divided into 2 groups at random with the ratio of 1:1; 60 examples are organized in treatment, matched group 60 examples, 55 ± 12 years old mean age; All case history courses of disease are the longest 14 years, and are the shortest 5 years.Two groups of basic conditions are learned statistics there was no significant difference (P〉0.05) by statistics.
All patients are all through Primary Care: (1) low salt diet, and note control body weight, harmonizing emotions; (2) control is infected; (3) wine for giving off smoking; (4) appropriate exercise.
Matched group: enalapril meleate benazepril 10mg once a day, make controlling of blood pressure below 140/85mmHg, if still fail up to standardly after 2 weeks, then benazepril dosage doubles.
Treatment group: on the basis of enalapril meleate benazepril, take the tablet of the embodiment of the invention 4, every day twice, take the medicine that is equivalent to crude drug amount 40g at every turn.
The experiment situation sees the following form:
One, two groups for the treatment of front and back blood pressure relatively
SBP represents systolic pressure in the table 1, and DBP represents diastolic pressure;
Blood pressure comparison before and after the table 1 liang group treatment (± S)
Annotate: in the group relatively: ▲ P＜0.05 ▲ ▲ P＜0.01 group between relatively: △ P＜0.05 △ △ P＜0.01
Table 1 result shows that treatment group systolic pressure begins to occur remarkable decline (P＜0.05) after 1 week for the treatment of, highly significant decline (P＜0.01) occurs after two weeks; And obviously descending (P＜0.05) just appearred after 2 weeks in matched group, and (P＜0.01) very obviously descended after 4 weeks; And two groups of curative effect significant differences (P＜0.05) after 2 weeks.The back appearance significantly descends (P＜0.05) treatment group diastolic pressure in 1 week equally, and the back decline of 2 weeks is (P＜0.01) very obviously; The decline (P＜0.01) of highly significant is also arranged in 2 weeks of matched group, but there are significant difference (P＜0.05, P＜0.01) in 4 all after-contraction pressures, two groups of curative effects of diastolic pressure.As seen Chinese medicine of the present invention and depressor benazepril have produced synergism, have promoted benazepril and have treated hypertensive effect.
Two, two groups for the treatment of front and back serum creatinines, blood urea nitrogens change relatively
Cr represents serum creatinine in the table 2, and BUN represents blood urea nitrogen;
Before and after the treatment of table 2 liang group Cr, a BUN change relatively (
± S)
Table 2 result shows before and after two groups of treatments serum creatinine, blood urea nitrogens there are no significant difference (P〉0.05), before and after two groups of treatments of results suggest renal function is influenced not statistically significant.
Three, α 1-microglobulin, blood wing chalone changed relatively during urinated two groups for the treatment of front and back
α 1-MG represents α 1-microglobulin in the table 3, and CYC represents blood wing chalone;
Before and after the treatment of table 3 liang group in the urine α 1-microglobulin, blood wing chalone change relatively (± S)
Table 3 result shows α 1-microglobulin, has significant difference (P＜0.01) before and after the treatment for the treatment of group, significant difference (P＜0.05) before and after the treatment of control group, and the two groups of curative effects in treatment back relatively have significant difference (P＜0.01); And blood wing chalone, (there are significance (P＜0.05) in significant difference (P＜0.05) before and after (P＜0.01), treatment of control group, two groups for the treatment of back curative effects also difference to difference highly significant before and after the treatment group treatment.This shows that Chinese medicine of the present invention effectively alleviated the early stage renal damage patient of hypertension renal fibrosis process.
Four, two groups of final clinical efficacies relatively
Treatment group and total efficacy result such as table 4 after 4 weeks of matched group medication;
Table 4 liang group treatment clinical efficacy relatively
| ? | Clinical recovery | Clinical produce effects | Clinical effective | Invalid | Total effective rate |
| The treatment group | 17 examples (28.33%) | 20 examples (33.33%) | 15 examples (25.00%) | 8 examples (13.33%) | 86.67% |
| Matched group | 8 examples (13.33) | 14 examples (23.33%) | 18 examples (30.00%) | 20 examples (33.33%) | 66.67% |
Check two groups of curative effects that significant difference (P＜0.01) is arranged through Riddit
Table 4 result shows that treatment group total effective rate is 86.67%, the matched group total effective rate is 66.67%, and there is significant difference (P＜0.01) in two groups of general curative effects through the Riddit check, have used the treatment group of Chinese medicine of the present invention, and whole curative effect has very significantly lifting.
Embodiment 7
Lee * * man, 62 years old, Guangxi melt water people from county, the course of disease 6 years.The patient suffered from hypertension before 6 years, took nifedipine sheet blood pressure lowering treatment always, the basic held stationary of blood pressure, and nocturia gradually occurring in nearly 2 years increases, and about 2-3 time every night, accompanies fatigue and weakness, clear urine in large amounts.Fatigue and weakness disappears no nocturia after treating for three weeks.Blood pressure is steady.
Wu * * man, 45 years old, fish people from frontal zone, Liuzhou city, the course of disease 4 years.The patient before 4 years during health check-up blood pressure higher, BP165/90mmhg without regular treatment, obeys blood pressure lowering certainly and waits antihypertensive drugs No. 0.Occur dizzy nearly half a year, afternoon for very, fatigue and weakness, and clear urine in large amounts, nocturia 2-3 time is accompanied xerostomia, bitter taste, poor appetite.The dark red yellow fur thready and stringy pulse of tongue.Through benefit dizzy disappearance after aquatic new two weeks of drink treatment, urine is transferred, no nocturia.Blood pressure is steady.
Tang * * woman, 58 years old, Liuzhou city Chengzhong District people, the course of disease 10 years.The patient occurred dizzy before 10 years, sleepy, measuring blood pressure 155/95mmhg takes depressor such as nifedipine always, and fluctuation is arranged during blood pressure.Occur dizzy nearly March, xerostomia, and binocular dryness, blurred vision, very then hectic fever in the afternoon sweating, the urine amount is many, nocturia 1-2 time, constipation with dry stool.The few thready and stringy pulse of the dark red tongue of tongue.Through the adjustment antihypertensive drugs, and take back transference cures of bright three week of medicine of this law, urine is transferred.The red tongue with thin fur the lung-pulse is thin.
Claims (6)
1. Chinese medicine for the treatment of the early stage renal damage of hypertension is characterized in that it is to be formed by the feedstock production that comprises following weight portion:
Radix Rehmanniae Preparata 5～30 Fructus Corni 5～30 Rhizoma Dioscoreaes 8～40
The Cortex Eucommiae 5～30 Radix Salviae Miltiorrhizaes 8～30 Carapax Et Plastrum Testudiniss 8～40.
2. the Chinese medicine of the early stage renal damage for the treatment of hypertension as claimed in claim 1 is characterized in that it is to be formed by the feedstock production that comprises following weight portion:
Radix Rehmanniae Preparata 10～20 Fructus Corni 10～20 Rhizoma Dioscoreaes 15～25
The Cortex Eucommiae 10～20 Radix Salviae Miltiorrhizaes 15～25 Carapax Et Plastrum Testudiniss 15～25.
3. the Chinese medicine of the early stage renal damage for the treatment of hypertension as claimed in claim 2 is characterized in that it is to be formed by the feedstock production that comprises following weight portion:
Radix Rehmanniae Preparata 12 Fructus Corni 12 Rhizoma Dioscoreaes 15
The Cortex Eucommiae 10 Radix Salviae Miltiorrhizaes 15 Carapax Et Plastrum Testudiniss 15.
4. the Chinese medicine of the early stage renal damage for the treatment of hypertension as claimed in claim 1 is characterized in that its active component is prepared from by the following method:
Get whole 6 flavor medical materials, extracting in water twice adds the water that is equivalent to 8～12 times of medical material gross weights for the first time, extracts 1～3 hour, adds the water that is equivalent to 8～12 times of medical material gross weights for the second time, extracts 1～2 hour; Merge extractive liquid,, relative density is 1.20～1.30 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 50%～65%, stir even, left standstill 12～24 hours, filter, relative density was 1.20～1.30 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
5. the Chinese medicine of the early stage renal damage of hypertension is treated in treatment as claimed in claim 1, it is characterized in that its active component is prepared from by the following method:
Get whole 6 flavor medical materials, extracting in water twice adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds the water that is equivalent to 8～10 times of medical material gross weights for the second time, extracts 1.5 hours; Merge extractive liquid,, relative density is 1.25 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 55%～60%, stir and spare, left standstill 12～24 hours, filter, relative density was 1.25 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
6. a Chinese medicine preparation for the treatment of the early stage renal damage of hypertension comprises the Chinese medicine of each the early stage renal damage for the treatment of hypertension in the claim 1～5 and pharmaceutically acceptable carrier.
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| CN109316557A (en) * | 2018-12-12 | 2019-02-12 | 扬州市中医院 | Compound traditional Chinese medicine composite of the anti-hypertension Renal Injury with carotid atherosclerosis |
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| CN1301122C (en) * | 2004-06-23 | 2007-02-21 | 敦化市瑞隆药业有限责任公司 | Bone strengthening granule of tortoise plastron and astragalus root |
| CN101856471B (en) * | 2010-06-09 | 2012-11-21 | 杨青 | Chinese medicinal composition for tonifying kidney and strengthening body |
| CN102423421B (en) * | 2011-12-06 | 2014-06-11 | 陈中元 | Medicine for treating hypertension |
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