CN109316557A - Compound traditional Chinese medicine composite of the anti-hypertension Renal Injury with carotid atherosclerosis - Google Patents

Compound traditional Chinese medicine composite of the anti-hypertension Renal Injury with carotid atherosclerosis Download PDF

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CN109316557A
CN109316557A CN201811516956.1A CN201811516956A CN109316557A CN 109316557 A CN109316557 A CN 109316557A CN 201811516956 A CN201811516956 A CN 201811516956A CN 109316557 A CN109316557 A CN 109316557A
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weight fraction
tuber
atractylodis macrocephalae
gorgon fruit
chinese medicine
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王道成
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Yangzhou Hospital Of Tcm
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Abstract

The invention discloses a kind of anti-hypertension Renal Injuries with the compound traditional Chinese medicine composite of carotid atherosclerosis, raw material including following parts by weight: Rehmannia glutinosa 10-90g, Gorgon fruit 8-60g, Rhizoma Gastrodiae 2-30g, Radix Notoginseng powder 1-20g, radix cyathulae 3-30g, polygonum cuspidate 2-20g, Rhizoma Atractylodis Macrocephalae 5-30g and tuber of pinellia 2-26g processed, preparation method includes the following steps: weighing Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, radix cyathulae, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed in proportion, first Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed mix and add water submerged.Present invention preparation is simple, pass through the compound traditional Chinese medicine composite of decoction and the available anti-hypertension Renal Injury companion carotid atherosclerosis of concentration to medicinal material, hypertension early-stage kidney damage kidneys of patients progression of fibrosis can be effectively relieved, mitigate kidneys of patients burden, and effective alleviation atherosclerosis crowd symptom, effective blood pressure lowering and reducing blood lipid, Small side effects are not likely to produce tolerance.

Description

Compound traditional Chinese medicine composite of the anti-hypertension Renal Injury with carotid atherosclerosis
Technical field
The answering with carotid atherosclerosis the present invention relates to field of medicaments more particularly to a kind of anti-hypertension Renal Injury Square Chinese medicine composition.
Background technique
China's adult hypertension illness rate is 18.8%, there is hypertensive patient about 1.6 hundred million at present.Since kidney is hypertension One of first target organs of damage, data show that as caused by hypertension kidney damage and enter chronic renal insufficiency Patient numbers are in increase year by year, therefore how to prevent and treat Kidney Damage by Hypertensive Disease, especially Renal Injury, and the development of the state of an illness is delayed to have There is highly important clinical meaning, atherosclerosis is one of the common disease for seriously endangering human health, frequently-occurring disease.In west National atherosclerotic cardiovascular disease is referred to as " number one killer ", practises as our people's living standard is improved with diet Used change, the disease also become the major causes of death in China.
Clinic mainly based on the western medicine of reducing blood lipid and blood pressure lowering, needs Long-term taking medicine, and side effect is more, easily produces Raw tolerance, so we provide anti-hypertension Renal Injuries with the compound traditional Chinese medicine composite of carotid atherosclerosis, use It is set forth above in solving the problems, such as.
Summary of the invention
Technical problems based on background technology, the invention proposes a kind of anti-hypertension Renal Injuries with arteria carotis The compound traditional Chinese medicine composite of atherosis.
The compound traditional Chinese medicine composite of anti-hypertension Renal Injury companion carotid atherosclerosis proposed by the present invention, including with The raw material of lower parts by weight: Rehmannia glutinosa 10-90g, Gorgon fruit 8-60g, Rhizoma Gastrodiae 2-30g, Radix Notoginseng powder 1-20g, radix cyathulae 3-30g, polygonum cuspidate 2-20g, Rhizoma Atractylodis Macrocephalae 5-30g and tuber of pinellia 2-26g processed.
Preparation method includes the following steps: weigh in proportion Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, radix cyathulae, polygonum cuspidate, Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed are first mixed and add water submerged by Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed, Again by radix cyathulae and plus water submerged, static 5-15min pours out water after stirring, the cleaning to medicinal material is completed, by radix cyathulae Powder is dried and be ground into, medicinal material total weight 9- is added to Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed 16 times of warm water impregnates 10-15min, then decocts 1.5-3.5 hours, and decocting liquid is obtained by filtration, adds medicinal material total weight 6-10 Warm water again decocts 1-2 hours, decocting liquid is obtained by filtration, two decocting liquids are merged and filtered, filtrate are obtained, by radix cyathulae Powder be added in filtrate, be sufficiently stirred, mixed liquor be concentrated into medicinal extract, it is dry and crush anti-hypertension morning can be obtained Compound traditional Chinese medicine composite of the phase renal damage with carotid atherosclerosis.
Preferably, the weight fraction of the Rehmannia glutinosa is 20-80g, the weight fraction of Gorgon fruit is 20-50g, the weight of Rhizoma Gastrodiae Score is 10-20g, the weight fraction of Radix Notoginseng powder is 5-20g, the weight fraction of radix cyathulae is 3-12g, the weight fraction of polygonum cuspidate is 2-15g, Rhizoma Atractylodis Macrocephalae weight fraction be 5-30g and the weight fraction of the tuber of pinellia processed is 2-26g.
Preferably, the temperature of the warm water is 40-50 DEG C.
Preferably, the weight fraction of the Rehmannia glutinosa is 10-90g, the weight fraction of Gorgon fruit is 8-60g, the weight of Rhizoma Gastrodiae Score is 2-30g, the weight fraction of Radix Notoginseng powder is 10-15g, the weight fraction of radix cyathulae is 5-8g, the weight fraction of polygonum cuspidate is 6-12g, Rhizoma Atractylodis Macrocephalae weight fraction be 5-30g and the weight fraction of the tuber of pinellia processed is 2-26g.
Preferably, the weight fraction of the Rehmannia glutinosa is 10-90g, the weight fraction of Gorgon fruit is 8-60g, the weight of Rhizoma Gastrodiae Score is 2-30g, the weight fraction of Radix Notoginseng powder is 5-20g, the weight fraction of radix cyathulae is 3-12g, the weight fraction of polygonum cuspidate is 2-15g, Rhizoma Atractylodis Macrocephalae weight fraction be 8-20g and the weight fraction of the tuber of pinellia processed is 8-19g.
Preferably, the weight fraction of the Rehmannia glutinosa is 30-60g, the weight fraction of Gorgon fruit is 8-60g, the weight of Rhizoma Gastrodiae Score is 2-30g, the weight fraction of Radix Notoginseng powder is 10-15g, the weight fraction of radix cyathulae is 3-12g, the weight fraction of polygonum cuspidate is 2-15g, Rhizoma Atractylodis Macrocephalae weight fraction be 8-20g and the weight fraction of the tuber of pinellia processed is 2-26g.
Preferably, the weight fraction of the Rehmannia glutinosa is 10-90g, the weight fraction of Gorgon fruit is 30-50g, the weight of Rhizoma Gastrodiae Score is 2-30g, the weight fraction of Radix Notoginseng powder is 5-20g, the weight fraction of radix cyathulae is 3-12g, the weight fraction of polygonum cuspidate is 5-10g, Rhizoma Atractylodis Macrocephalae weight fraction be 12-22g and the weight fraction of the tuber of pinellia processed is 9-18g.
Preferably, the weight fraction of the Rehmannia glutinosa is 10-90g, the weight fraction of Gorgon fruit is 30-45g, the weight of Rhizoma Gastrodiae Score is 2-30g, the weight fraction of Radix Notoginseng powder is 5-20g, the weight fraction of radix cyathulae is 3-12g, the weight fraction of polygonum cuspidate is 6-9g, Rhizoma Atractylodis Macrocephalae weight fraction be 12-22g and the weight fraction of the tuber of pinellia processed is 9-18g.
Preferably, the weight fraction of the Rehmannia glutinosa is 25-80g, the weight fraction of Gorgon fruit is 25-45g, the weight of Rhizoma Gastrodiae Score is 2-30g, the weight fraction of Radix Notoginseng powder is 5-20g, the weight fraction of radix cyathulae is 3-8g, the weight fraction of polygonum cuspidate is 5- 10g, Rhizoma Atractylodis Macrocephalae weight fraction be 12-19g and the weight fraction of the tuber of pinellia processed is 9-18g.
Preferably, in preparation process, Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, radix cyathulae, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae are weighed in proportion With the tuber of pinellia processed, first Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed are mixed and add water submerged, then will Radix cyathulae adds water submerged, and static 9-12min pours out water after stirring, completes the cleaning to medicinal material, simultaneously by radix cyathulae drying It is ground into powder, 10-14 times of medicinal material total weight is added to Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed Warm water impregnates 12-14min, then decocts 2-3 hours, and decocting liquid is obtained by filtration, adds the warm water of 7-9 times of medicinal material total weight, decocts It boils 1.5-2 hours, decocting liquid is obtained by filtration, two decocting liquids are merged and filtered, filtrate is obtained, the powder of radix cyathulae is added It in filtrate, is sufficiently stirred, mixed liquor is concentrated into medicinal extract, drying and crushing can be obtained anti-hypertension Renal Injury companion The compound traditional Chinese medicine composite of carotid atherosclerosis.
The beneficial effects of the present invention are: by adding to Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed Water decocts available decocting liquid, and the powder by the way that radix cyathulae is added into decocting liquid is sufficiently stirred and mixed liquor is concentrated To medicinal extract, compound traditional Chinese medicine composite that is dry and crushing available anti-hypertension Renal Injury companion carotid atherosclerosis, Present invention preparation is simple, athero- hard with arteria carotis by decoction to medicinal material and the available anti-hypertension Renal Injury of concentration Hypertension early-stage kidney damage kidneys of patients progression of fibrosis can be effectively relieved in the compound traditional Chinese medicine composite of change, mitigate patient's kidney Dirty burden, and effective alleviation atherosclerosis crowd symptom, effective blood pressure lowering and reducing blood lipid, Small side effects, are not easy to produce Raw tolerance.
Specific embodiment
Combined with specific embodiments below the present invention is made further to explain.
Embodiment one
The invention proposes anti-hypertension Renal Injuries with the compound traditional Chinese medicine composite of carotid atherosclerosis, including with The raw material of lower parts by weight: Rehmannia glutinosa 20g, Gorgon fruit 30g, Rhizoma Gastrodiae 10g, Radix Notoginseng powder 15g, radix cyathulae 5g, polygonum cuspidate 4g, Rhizoma Atractylodis Macrocephalae 8g and system Tuber of pinellia 8g.
Preparation method includes the following steps: weigh in proportion Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, radix cyathulae, polygonum cuspidate, Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed are first mixed and add water submerged by Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed, Radix cyathulae is added into water submerged again, static 8min pours out water after stirring, completes the cleaning to medicinal material, radix cyathulae is dried And it is ground into powder, 10 times of medicinal material total weight are added to Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed Warm water impregnates 12min, then decocts 1.5 hours, and decocting liquid is obtained by filtration, and adds 7 times of medicinal material total weight of warm water, and it is small to decoct 1 When, decocting liquid is obtained by filtration, two decocting liquids are merged and filtered, filtrate is obtained, the powder of radix cyathulae is added in filtrate, into It goes and is sufficiently stirred, mixed liquor is concentrated into medicinal extract, drying and crushing can be obtained anti-hypertension Renal Injury with arteria carotis congee The compound traditional Chinese medicine composite of sample hardening.
Embodiment two
The invention proposes anti-hypertension Renal Injuries with the compound traditional Chinese medicine composite of carotid atherosclerosis, including with The raw material of lower parts by weight: Rehmannia glutinosa 60g, Gorgon fruit 50g, Rhizoma Gastrodiae 20g, Radix Notoginseng powder 15g, radix cyathulae 8g, polygonum cuspidate 6g, Rhizoma Atractylodis Macrocephalae 15g and Tuber of pinellia 12g processed.
Preparation method includes the following steps: weigh in proportion Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, radix cyathulae, polygonum cuspidate, Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed are first mixed and add water submerged by Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed, Radix cyathulae is added into water submerged again, static 10min pours out water after stirring, completes the cleaning to medicinal material, radix cyathulae is dried And it is ground into powder, 12 times of medicinal material total weight are added to Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed Warm water impregnates 12min, then decocts 2 hours, and decocting liquid is obtained by filtration, and adds 8 times of medicinal material total weight of warm water, and it is small to decoct 1.5 When, decocting liquid is obtained by filtration, two decocting liquids are merged and filtered, filtrate is obtained, the powder of radix cyathulae is added in filtrate, into It goes and is sufficiently stirred, mixed liquor is concentrated into medicinal extract, drying and crushing can be obtained anti-hypertension Renal Injury with arteria carotis congee The compound traditional Chinese medicine composite of sample hardening.
Embodiment three
The invention proposes anti-hypertension Renal Injuries with the compound traditional Chinese medicine composite of carotid atherosclerosis, including with The raw material of lower parts by weight: Rehmannia glutinosa 15g, Gorgon fruit 30g, Rhizoma Gastrodiae 10g, Radix Notoginseng powder 3g, radix cyathulae 15g, polygonum cuspidate 15g, Rhizoma Atractylodis Macrocephalae 10g and Tuber of pinellia 10g processed.
Preparation method includes the following steps: weigh in proportion Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, radix cyathulae, polygonum cuspidate, Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed are first mixed and add water submerged by Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed, Radix cyathulae is added into water submerged again, static 12min pours out water after stirring, completes the cleaning to medicinal material, radix cyathulae is dried And it is ground into powder, 15 times of medicinal material total weight are added to Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed Warm water impregnates 13min, then decocts 3 hours, and decocting liquid is obtained by filtration, and adds 9 times of medicinal material total weight of warm water, and it is small to decoct 1.8 When, decocting liquid is obtained by filtration, two decocting liquids are merged and filtered, filtrate is obtained, the powder of radix cyathulae is added in filtrate, into It goes and is sufficiently stirred, mixed liquor is concentrated into medicinal extract, drying and crushing can be obtained anti-hypertension Renal Injury with arteria carotis congee The compound traditional Chinese medicine composite of sample hardening.
Herbal mixture to anti-hypertension Renal Injury made from embodiment one to three with carotid atherosclerosis combines Object, comparison valsartan amlodipine piece (Novartis Pharma Schweiz AG, authentication code: traditional Chinese medicines H20090840, specification: 80 millis Gram: 5 milligrams /) and Simvastatin, it is shown that the experimental data are shown in the following table:
By above table it is found that anti-hypertension Renal Injury proposed by the present invention is in the compound of carotid atherosclerosis Drug composition, which has, to be significantly improved, and embodiment three is most preferred embodiment.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (10)

1. anti-hypertension Renal Injury is with the compound traditional Chinese medicine composite of carotid atherosclerosis, which is characterized in that including following The raw material of parts by weight: Rehmannia glutinosa 10-90g, Gorgon fruit 8-60g, Rhizoma Gastrodiae 2-30g, Radix Notoginseng powder 1-20g, radix cyathulae 3-30g, polygonum cuspidate 2- 20g, Rhizoma Atractylodis Macrocephalae 5-30g and tuber of pinellia 2-26g processed.
Preparation method includes the following steps: weighing Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, radix cyathulae, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae in proportion With the tuber of pinellia processed, first Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed are mixed and add water submerged, then will Radix cyathulae adds water submerged, and static 5-15min pours out water after stirring, completes the cleaning to medicinal material, simultaneously by radix cyathulae drying It is ground into powder, 9-16 times of medicinal material total weight is added to Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed Warm water impregnates 10-15min, then decocts 1.5-3.5 hours, and decocting liquid is obtained by filtration, adds the temperature of 6-10 times of medicinal material total weight Water decocts 1-2 hours, decocting liquid is obtained by filtration, two decocting liquids are merged and filtered, obtain filtrate, by the powder of radix cyathulae It is added in filtrate, is sufficiently stirred, mixed liquor is concentrated into medicinal extract, drying and crushing can be obtained anti-hypertension early stage kidney damage Compound traditional Chinese medicine composite of the evil with carotid atherosclerosis.
2. the compound traditional Chinese medicine composite of anti-hypertension Renal Injury companion carotid atherosclerosis according to claim 1, It is characterized in that, the weight fraction of the Rehmannia glutinosa is 20-80g, the weight fraction of Gorgon fruit is 20-50g, the weight fraction of Rhizoma Gastrodiae Weight fraction for 10-20g, Radix Notoginseng powder is 5-20g, the weight fraction of radix cyathulae is 3-12g, the weight fraction of polygonum cuspidate is 2- 15g, Rhizoma Atractylodis Macrocephalae weight fraction be 5-30g and the weight fraction of the tuber of pinellia processed is 2-26g.
3. the compound traditional Chinese medicine composite of anti-hypertension Renal Injury companion carotid atherosclerosis according to claim 1, It is characterized in that, the temperature of the warm water is 40-50 DEG C.
4. the compound traditional Chinese medicine composite of anti-hypertension Renal Injury companion carotid atherosclerosis according to claim 1, It is characterized in that, the weight fraction of the Rehmannia glutinosa is 10-90g, the weight fraction of Gorgon fruit is 8-60g, the weight fraction of Rhizoma Gastrodiae Weight fraction for 2-30g, Radix Notoginseng powder is 10-15g, the weight fraction of radix cyathulae is 5-8g, the weight fraction of polygonum cuspidate is 6- 12g, Rhizoma Atractylodis Macrocephalae weight fraction be 5-30g and the weight fraction of the tuber of pinellia processed is 2-26g.
5. the compound traditional Chinese medicine composite of anti-hypertension Renal Injury companion carotid atherosclerosis according to claim 1, It is characterized in that, the weight fraction of the Rehmannia glutinosa is 10-90g, the weight fraction of Gorgon fruit is 8-60g, the weight fraction of Rhizoma Gastrodiae Weight fraction for 2-30g, Radix Notoginseng powder is 5-20g, the weight fraction of radix cyathulae is 3-12g, the weight fraction of polygonum cuspidate is 2- 15g, Rhizoma Atractylodis Macrocephalae weight fraction be 8-20g and the weight fraction of the tuber of pinellia processed is 8-19g.
6. the compound traditional Chinese medicine composite of anti-hypertension Renal Injury companion carotid atherosclerosis according to claim 1, It is characterized in that, the weight fraction of the Rehmannia glutinosa is 30-60g, the weight fraction of Gorgon fruit is 8-60g, the weight fraction of Rhizoma Gastrodiae Weight fraction for 2-30g, Radix Notoginseng powder is 10-15g, the weight fraction of radix cyathulae is 3-12g, the weight fraction of polygonum cuspidate is 2- 15g, Rhizoma Atractylodis Macrocephalae weight fraction be 8-20g and the weight fraction of the tuber of pinellia processed is 2-26g.
7. the compound traditional Chinese medicine composite of anti-hypertension Renal Injury companion carotid atherosclerosis according to claim 1, It is characterized in that, the weight fraction of the Rehmannia glutinosa is 10-90g, the weight fraction of Gorgon fruit is 30-50g, the weight fraction of Rhizoma Gastrodiae Weight fraction for 2-30g, Radix Notoginseng powder is 5-20g, the weight fraction of radix cyathulae is 3-12g, the weight fraction of polygonum cuspidate is 5- 10g, Rhizoma Atractylodis Macrocephalae weight fraction be 12-22g and the weight fraction of the tuber of pinellia processed is 9-18g.
8. the compound traditional Chinese medicine composite of anti-hypertension Renal Injury companion carotid atherosclerosis according to claim 1, It is characterized in that, the weight fraction of the Rehmannia glutinosa is 10-90g, the weight fraction of Gorgon fruit is 30-45g, the weight fraction of Rhizoma Gastrodiae Weight fraction for 2-30g, Radix Notoginseng powder is 5-20g, the weight fraction of radix cyathulae is 3-12g, the weight fraction of polygonum cuspidate be 6-9g, The weight fraction of Rhizoma Atractylodis Macrocephalae is 12-22g and the weight fraction of the tuber of pinellia processed is 9-18g.
9. the compound traditional Chinese medicine composite of anti-hypertension Renal Injury companion carotid atherosclerosis according to claim 1, It is characterized in that, the weight fraction of the Rehmannia glutinosa is 25-80g, the weight fraction of Gorgon fruit is 25-45g, the weight fraction of Rhizoma Gastrodiae Weight fraction for 2-30g, Radix Notoginseng powder is 5-20g, the weight fraction of radix cyathulae is 3-8g, the weight fraction of polygonum cuspidate be 5-10g, The weight fraction of Rhizoma Atractylodis Macrocephalae is 12-19g and the weight fraction of the tuber of pinellia processed is 9-18g.
10. the compound traditional Chinese medicine composite of anti-hypertension Renal Injury companion carotid atherosclerosis according to claim 1, It is characterized in that, weighing Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, radix cyathulae, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and system in proportion in preparation process Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed are first mixed and add water submerged by the tuber of pinellia, then by river ox Knee adds water submerged, and static 9-12min pours out water after stirring, completes the cleaning to medicinal material, radix cyathulae is dried and crushed At powder, the temperature of 10-14 times of medicinal material total weight is added to Rehmannia glutinosa, Gorgon fruit, Rhizoma Gastrodiae, Radix Notoginseng powder, polygonum cuspidate, Rhizoma Atractylodis Macrocephalae and the tuber of pinellia processed Water impregnates 12-14min, then decocts 2-3 hours, and decocting liquid is obtained by filtration, adds the warm water of 7-9 times of medicinal material total weight, decocts 1.5-2 hours, decocting liquid is obtained by filtration, two decocting liquids are merged and filtered, filtrate is obtained, filter is added in the powder of radix cyathulae It in liquid, is sufficiently stirred, mixed liquor is concentrated into medicinal extract, drying and crushing can be obtained anti-hypertension Renal Injury with neck The compound traditional Chinese medicine composite of atherosclerosis.
CN201811516956.1A 2018-12-12 2018-12-12 Compound traditional Chinese medicine composite of the anti-hypertension Renal Injury with carotid atherosclerosis Pending CN109316557A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101843696A (en) * 2009-10-16 2010-09-29 北京绿源求证科技发展有限责任公司 Chinese medicament for treating diabetic nephropathy
CN101843803A (en) * 2009-10-28 2010-09-29 北京绿源求证科技发展有限责任公司 Chinese medicament for treating diabetic nephropathy
CN102793826A (en) * 2012-09-04 2012-11-28 柳州市中医院 Traditional Chinese medicine for treating hypertension early-stage kidney damage and preparation method thereof
CN104887766A (en) * 2015-05-27 2015-09-09 胡怀强 Traditional Chinese medicine compound capsules for treating atherosclerosis and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101843696A (en) * 2009-10-16 2010-09-29 北京绿源求证科技发展有限责任公司 Chinese medicament for treating diabetic nephropathy
CN101843803A (en) * 2009-10-28 2010-09-29 北京绿源求证科技发展有限责任公司 Chinese medicament for treating diabetic nephropathy
CN102793826A (en) * 2012-09-04 2012-11-28 柳州市中医院 Traditional Chinese medicine for treating hypertension early-stage kidney damage and preparation method thereof
CN104887766A (en) * 2015-05-27 2015-09-09 胡怀强 Traditional Chinese medicine compound capsules for treating atherosclerosis and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张金玺: "补肾祛痰熄风汤联合西药治疗椎/基底动脉供血不足性眩晕64例", 《新中医》 *

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Application publication date: 20190212